KLHL25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)7.66199929
2polyketide metabolic process (GO:0030638)7.66199929
3doxorubicin metabolic process (GO:0044598)7.66199929
4maintenance of protein location in nucleus (GO:0051457)5.24655333
5somite rostral/caudal axis specification (GO:0032525)5.09717503
6protein localization to kinetochore (GO:0034501)5.01705281
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.81333297
8regulation of response to osmotic stress (GO:0047484)4.78293528
9coenzyme catabolic process (GO:0009109)4.77747154
10negative regulation of epidermis development (GO:0045683)4.73912814
11cellular modified amino acid catabolic process (GO:0042219)4.72615123
12postsynaptic membrane organization (GO:0001941)4.66153978
13aminoglycoside antibiotic metabolic process (GO:0030647)4.65841252
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.58489715
15sulfur amino acid catabolic process (GO:0000098)4.50530428
16hormone catabolic process (GO:0042447)4.47550687
17muscle organ morphogenesis (GO:0048644)4.34721039
18pyrimidine nucleobase catabolic process (GO:0006208)4.27712567
19heterochromatin organization (GO:0070828)4.25639259
20presynaptic membrane assembly (GO:0097105)4.24901119
21negative regulation of cell cycle G2/M phase transition (GO:1902750)4.21663561
22regulation of telomere maintenance via telomerase (GO:0032210)4.16424356
23interferon-gamma production (GO:0032609)4.14553756
24rRNA transcription (GO:0009303)4.13597297
25negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.11927865
26DNA replication-dependent nucleosome assembly (GO:0006335)4.07063756
27DNA replication-dependent nucleosome organization (GO:0034723)4.07063756
28negative regulation of telomerase activity (GO:0051974)4.02717088
29epoxygenase P450 pathway (GO:0019373)4.02448163
30neuron cell-cell adhesion (GO:0007158)3.95098037
31establishment of mitochondrion localization (GO:0051654)3.92976997
32primary alcohol catabolic process (GO:0034310)3.92387640
33protein localization to chromosome, centromeric region (GO:0071459)3.92320411
34regulation of MHC class I biosynthetic process (GO:0045343)3.92151466
35histone H4-K5 acetylation (GO:0043981)3.87589845
36histone H4-K8 acetylation (GO:0043982)3.87589845
37mitotic sister chromatid segregation (GO:0000070)3.84445217
38maternal placenta development (GO:0001893)3.77624470
39paraxial mesoderm development (GO:0048339)3.76339149
40primitive streak formation (GO:0090009)3.74860991
41chromatin assembly (GO:0031497)3.72353212
42positive regulation of histone deacetylation (GO:0031065)3.71622470
43layer formation in cerebral cortex (GO:0021819)3.69868202
44presynaptic membrane organization (GO:0097090)3.67049740
45positive regulation of protein deacetylation (GO:0090312)3.60030301
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.57727429
47negative regulation of epidermal cell differentiation (GO:0045605)3.51610680
48histone H4-K12 acetylation (GO:0043983)3.50628421
49nucleoside transmembrane transport (GO:1901642)3.49088628
50planar cell polarity pathway involved in neural tube closure (GO:0090179)3.45245087
51regulation of cilium movement (GO:0003352)3.41935990
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.41365214
53nuclear pore complex assembly (GO:0051292)3.40454451
54sister chromatid segregation (GO:0000819)3.39479590
55pre-miRNA processing (GO:0031054)3.37145329
56notochord development (GO:0030903)3.35320276
57axonal fasciculation (GO:0007413)3.33543211
58vocalization behavior (GO:0071625)3.31614303
59cofactor catabolic process (GO:0051187)3.30561299
60heme transport (GO:0015886)3.27860603
61intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.25486098
62retinoic acid receptor signaling pathway (GO:0048384)3.23807214
63RNA stabilization (GO:0043489)3.23545031
64mRNA stabilization (GO:0048255)3.23545031
65regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21843265
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.19310133
67cell migration in hindbrain (GO:0021535)3.18732607
68response to dietary excess (GO:0002021)3.17011388
69negative regulation of oligodendrocyte differentiation (GO:0048715)3.14741082
70L-ascorbic acid metabolic process (GO:0019852)3.14432910
71neuron recognition (GO:0008038)3.13797233
72nucleobase catabolic process (GO:0046113)3.13106315
73cell-cell junction maintenance (GO:0045217)3.12697352
74regulation of translation in response to stress (GO:0043555)3.10632395
75auditory behavior (GO:0031223)3.08800644
76positive regulation of DNA-dependent DNA replication (GO:2000105)3.05840861
77regulation of NFAT protein import into nucleus (GO:0051532)3.04424624
78regulation of apoptotic process involved in morphogenesis (GO:1902337)3.03033419
79RNA localization (GO:0006403)3.02636008
80maintenance of protein localization in organelle (GO:0072595)3.02138518
81regulation of somitogenesis (GO:0014807)3.02062563
82response to auditory stimulus (GO:0010996)3.00801260
83cofactor transport (GO:0051181)2.99897179
84peptidyl-arginine omega-N-methylation (GO:0035247)2.98811043
85alpha-linolenic acid metabolic process (GO:0036109)2.97287023
86intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.96799581
87microtubule severing (GO:0051013)2.95468953
88establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95146189
89mitochondrion transport along microtubule (GO:0047497)2.95146189
90cytidine deamination (GO:0009972)2.94937847
91cytidine metabolic process (GO:0046087)2.94937847
92cytidine catabolic process (GO:0006216)2.94937847
93drug metabolic process (GO:0017144)2.94899491
94phenol-containing compound catabolic process (GO:0019336)2.92942461
95quinone metabolic process (GO:1901661)2.92851539
96branching involved in mammary gland duct morphogenesis (GO:0060444)2.91204809
97histone H4-K16 acetylation (GO:0043984)2.90759559
98amino acid import (GO:0043090)2.90120286
99neuronal stem cell maintenance (GO:0097150)2.88478863
100epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87402912
101triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86305073
102transepithelial transport (GO:0070633)2.86260698
103negative regulation of fibrinolysis (GO:0051918)2.86177145
104L-phenylalanine metabolic process (GO:0006558)2.84815811
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84815811
106gamma-aminobutyric acid transport (GO:0015812)2.83336062
107lung-associated mesenchyme development (GO:0060484)2.82743937
108regulation of apoptotic cell clearance (GO:2000425)2.82167931
109positive regulation of synapse maturation (GO:0090129)2.82144759
110convergent extension (GO:0060026)2.81556000
111semaphorin-plexin signaling pathway (GO:0071526)2.78275106
112nuclear pore organization (GO:0006999)2.75349739
113trophectodermal cell differentiation (GO:0001829)2.75092753
114cochlea morphogenesis (GO:0090103)2.74934687
115neurotransmitter-gated ion channel clustering (GO:0072578)2.72640702
116mitotic chromosome condensation (GO:0007076)2.71520959
117camera-type eye morphogenesis (GO:0048593)2.71056983
118axon extension (GO:0048675)2.69326450
119ear development (GO:0043583)2.68878157
120peptidyl-arginine methylation (GO:0018216)2.68606566
121peptidyl-arginine N-methylation (GO:0035246)2.68606566
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.68204545
123L-phenylalanine catabolic process (GO:0006559)2.68204545
124urea cycle (GO:0000050)2.64174589
125urea metabolic process (GO:0019627)2.64174589
126vitamin A metabolic process (GO:0006776)2.63912540
127calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63820100
128neuronal ion channel clustering (GO:0045161)2.63585494
129progesterone metabolic process (GO:0042448)2.63343902
130rRNA methylation (GO:0031167)2.62702015
131regulation of respiratory system process (GO:0044065)2.62571430
132protein-DNA complex disassembly (GO:0032986)2.61304531
133nucleosome disassembly (GO:0006337)2.61304531
134cellular response to cholesterol (GO:0071397)2.60567609
135phagocytosis, recognition (GO:0006910)2.60250553
136G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59770452
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59637448
138DNA replication checkpoint (GO:0000076)2.59585724
139pteridine-containing compound biosynthetic process (GO:0042559)2.59439672
140pentose-phosphate shunt (GO:0006098)2.58138992
141cell junction maintenance (GO:0034331)2.57727523
142glycine metabolic process (GO:0006544)2.56997058
143lens fiber cell development (GO:0070307)2.56877756
144regulation of lipoprotein particle clearance (GO:0010984)2.56744717
145intracellular estrogen receptor signaling pathway (GO:0030520)2.56629546
146apoptotic DNA fragmentation (GO:0006309)2.56117770
147fat-soluble vitamin metabolic process (GO:0006775)2.56091453
148L-serine metabolic process (GO:0006563)2.56080221
149regulation of glucose import in response to insulin stimulus (GO:2001273)2.55954862
150histone arginine methylation (GO:0034969)2.55744275
151nucleoside transport (GO:0015858)2.55742775
152negative regulation of interleukin-2 production (GO:0032703)2.54483432
153negative regulation of viral release from host cell (GO:1902187)2.53599302
154axon extension involved in axon guidance (GO:0048846)2.52126850
155neuron projection extension involved in neuron projection guidance (GO:1902284)2.52126850
156mechanosensory behavior (GO:0007638)2.50512714
157central nervous system projection neuron axonogenesis (GO:0021952)2.47079761
158apical protein localization (GO:0045176)2.46256443
159outer ear morphogenesis (GO:0042473)2.44131688
160ephrin receptor signaling pathway (GO:0048013)2.43965323
161cerebral cortex neuron differentiation (GO:0021895)2.43911255
162protein localization to synapse (GO:0035418)2.43020019
163synapse assembly (GO:0007416)2.42415441
164asymmetric protein localization (GO:0008105)2.42348520
165cranial nerve morphogenesis (GO:0021602)2.41528265
166sodium ion export (GO:0071436)2.40898427
167positive regulation of synapse assembly (GO:0051965)2.40616270
168regulation of inclusion body assembly (GO:0090083)2.40569424
169negative regulation of glial cell differentiation (GO:0045686)2.39034621
170neuron projection extension (GO:1990138)2.37556689
171oligodendrocyte differentiation (GO:0048709)2.37086847
172mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.36620339
173locomotory exploration behavior (GO:0035641)2.36416136
174dermatan sulfate biosynthetic process (GO:0030208)2.36098093
175neuron projection regeneration (GO:0031102)2.35709368
176cerebral cortex radially oriented cell migration (GO:0021799)2.34799389
177lens morphogenesis in camera-type eye (GO:0002089)2.32960760
178cytoskeletal anchoring at plasma membrane (GO:0007016)2.31722030
179neural tube development (GO:0021915)2.30566402
180hippocampus development (GO:0021766)2.28091101
181regulation of cholesterol biosynthetic process (GO:0045540)2.27360814
182dermatan sulfate metabolic process (GO:0030205)2.26933304
183spinal cord development (GO:0021510)2.26677331
184regulation of synapse structural plasticity (GO:0051823)2.26097083
185apoptotic process involved in morphogenesis (GO:0060561)2.25227648
186negative regulation of catenin import into nucleus (GO:0035414)2.24511773
187establishment of nucleus localization (GO:0040023)2.21396562
188negative regulation of smoothened signaling pathway (GO:0045879)2.20669323
189L-serine transport (GO:0015825)2.20426293
190neuron fate commitment (GO:0048663)2.20253864
191exploration behavior (GO:0035640)2.19089340
192acrosome reaction (GO:0007340)2.18703452
193proximal/distal pattern formation (GO:0009954)2.18659823
194developmental cell growth (GO:0048588)2.18463761
195biotin metabolic process (GO:0006768)2.18063573
196positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17884509
197heart valve formation (GO:0003188)2.17306930
198positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.15335599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.22249631
2EZH2_22144423_ChIP-Seq_EOC_Human4.75854786
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.63405281
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.63405281
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.63405281
6E2F7_22180533_ChIP-Seq_HELA_Human3.83035220
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.07373703
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94410497
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.79814884
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78766198
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69687440
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.62496440
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.45009709
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.30387598
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.27591711
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.26811317
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.26127790
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.22969732
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.19168315
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16248215
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12932313
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.12105733
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.09908716
24MYC_22102868_ChIP-Seq_BL_Human2.08964776
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00394887
26SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.98816092
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95530427
28* KDM2B_26808549_Chip-Seq_K562_Human1.93568436
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.92995828
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.91334787
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89330271
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89330271
33TCF3_18692474_ChIP-Seq_MEFs_Mouse1.89115202
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82982957
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.82667872
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81544561
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79829973
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79793848
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.77544543
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77108318
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76419236
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75134771
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74650179
44DROSHA_22980978_ChIP-Seq_HELA_Human1.73007126
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69872452
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.69430287
47CTCF_27219007_Chip-Seq_Bcells_Human1.69106370
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68462007
49EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67868399
50* LXR_22158963_ChIP-Seq_LIVER_Mouse1.67402148
51TCF7_22412390_ChIP-Seq_EML_Mouse1.66540658
52SCL_19346495_ChIP-Seq_HPC-7_Human1.66237182
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65974311
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64882952
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64493000
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63660472
57* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60203659
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59838080
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.57285752
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55838198
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53058725
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51348537
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49348256
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.48467171
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.44872343
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43758495
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.43362995
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42879222
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42376731
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42289264
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41445189
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41277293
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40866388
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.40710718
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40673588
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.38987633
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.36935275
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35407779
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.34738220
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.33747174
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.31916783
82MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31631884
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31520168
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30878226
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30361163
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29434340
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28840378
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.28463243
89NCOR1_26117541_ChIP-Seq_K562_Human1.28286232
90REST_21632747_ChIP-Seq_MESCs_Mouse1.28244575
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27395754
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26958860
93P68_20966046_ChIP-Seq_HELA_Human1.26801743
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26490003
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25304927
96LXR_22292898_ChIP-Seq_THP-1_Human1.24613637
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24449014
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23691915
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.21762071
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21353779
101TET1_21490601_ChIP-Seq_MESCs_Mouse1.21129192
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21050082
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.20469972
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19276871
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18921640
106PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18628593
107* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18160052
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18144994
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.17030840
110* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13501413
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12878813
112* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.12124855
113VDR_21846776_ChIP-Seq_THP-1_Human1.10855709
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10501649
115* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09755412
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09225411
117NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08834050
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08793689
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.08626186
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08398773
121* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07920699
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07706158
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07608847
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06891431
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06127768
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05921572
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.05057219
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04322179
129NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02349074
130CLOCK_20551151_ChIP-Seq_293T_Human1.02273897
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.01354547
132NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.00872474
133BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00809121
134SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00704415
135IRF1_19129219_ChIP-ChIP_H3396_Human1.00085880
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99790905
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.99033568
138CREB1_26743006_Chip-Seq_LNCaP_Human0.98667978
139CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98613666
140* RACK7_27058665_Chip-Seq_MCF-7_Human0.98047536
141UTX_26944678_Chip-Seq_JUKART_Human0.96066558
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.96064198
143KDM2B_26808549_Chip-Seq_DND41_Human0.94981284
144CTCF_21964334_Chip-Seq_Bcells_Human0.93839343
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93811762
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93499309
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93481864
148* TP53_22127205_ChIP-Seq_IMR90_Human0.93481839
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93258102
150BCOR_27268052_Chip-Seq_Bcells_Human0.93099761
151NOTCH1_21737748_ChIP-Seq_TLL_Human0.92304810
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92158238
153RUNX1_22412390_ChIP-Seq_EML_Mouse0.91968479
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91396124
155WDR5_24793694_ChIP-Seq_LNCAP_Human0.91192952
156MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91169474
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91005176
158MAF_26560356_Chip-Seq_TH1_Human0.90217681
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89728392
160E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89686448
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89150258
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88861083
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.88697472
164STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88695757
165RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88125474
166KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86572244
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84816359
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84400559
169SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83767059
170MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83373635
171MYC_18555785_ChIP-Seq_MESCs_Mouse0.83328208
172SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81938777
173RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81832528
174SMC4_20622854_ChIP-Seq_HELA_Human0.81298137
175MYC_19030024_ChIP-ChIP_MESCs_Mouse0.79525862
176NANOG_16518401_ChIP-PET_MESCs_Mouse0.79274381
177MYB_26560356_Chip-Seq_TH1_Human0.78957585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.53067120
2MP0002254_reproductive_system_inflammat3.98532813
3MP0003705_abnormal_hypodermis_morpholog3.36846340
4MP0004264_abnormal_extraembryonic_tissu3.32256175
5MP0004859_abnormal_synaptic_plasticity2.96582444
6MP0005360_urolithiasis2.87723083
7MP0003890_abnormal_embryonic-extraembry2.74509308
8MP0000778_abnormal_nervous_system2.68754783
9MP0005075_abnormal_melanosome_morpholog2.66275584
10MP0002249_abnormal_larynx_morphology2.58428259
11MP0002139_abnormal_hepatobiliary_system2.56987253
12MP0005670_abnormal_white_adipose2.49462635
13MP0004858_abnormal_nervous_system2.41661698
14MP0006292_abnormal_olfactory_placode2.40455732
15MP0004270_analgesia2.34644373
16MP0003136_yellow_coat_color2.26270911
17MP0000566_synostosis2.25384877
18MP0010352_gastrointestinal_tract_polyps2.22909189
19MP0006082_CNS_inflammation2.22339015
20MP0005423_abnormal_somatic_nervous2.05919535
21MP0002332_abnormal_exercise_endurance2.05497746
22MP0005499_abnormal_olfactory_system2.04817207
23MP0005394_taste/olfaction_phenotype2.04817207
24MP0002822_catalepsy2.04701843
25MP0002653_abnormal_ependyma_morphology2.04023856
26MP0009840_abnormal_foam_cell2.03061871
27MP0005365_abnormal_bile_salt1.96924344
28MP0005257_abnormal_intraocular_pressure1.96572436
29MP0000049_abnormal_middle_ear1.95785910
30MP0008875_abnormal_xenobiotic_pharmacok1.93262841
31MP0005085_abnormal_gallbladder_physiolo1.91345485
32MP0000537_abnormal_urethra_morphology1.80153948
33MP0004957_abnormal_blastocyst_morpholog1.79558077
34MP0000955_abnormal_spinal_cord1.66396358
35MP0008961_abnormal_basal_metabolism1.65687359
36MP0001849_ear_inflammation1.59954097
37MP0008057_abnormal_DNA_replication1.59462330
38MP0001529_abnormal_vocalization1.56731670
39MP0003191_abnormal_cellular_cholesterol1.55500237
40MP0001984_abnormal_olfaction1.53567021
41MP0003861_abnormal_nervous_system1.53102745
42MP0006035_abnormal_mitochondrial_morpho1.52238068
43MP0003806_abnormal_nucleotide_metabolis1.50147001
44MP0000609_abnormal_liver_physiology1.49473089
45MP0003635_abnormal_synaptic_transmissio1.49439035
46MP0009053_abnormal_anal_canal1.48388223
47MP0005666_abnormal_adipose_tissue1.48072316
48MP0003183_abnormal_peptide_metabolism1.47781873
49MP0000579_abnormal_nail_morphology1.46760745
50MP0000534_abnormal_ureter_morphology1.44549643
51MP0005380_embryogenesis_phenotype1.44455870
52MP0001672_abnormal_embryogenesis/_devel1.44455870
53MP0003329_amyloid_beta_deposits1.44243514
54MP0001346_abnormal_lacrimal_gland1.43904511
55MP0002697_abnormal_eye_size1.40341156
56MP0003942_abnormal_urinary_system1.40151114
57MP0002088_abnormal_embryonic_growth/wei1.38648945
58MP0003252_abnormal_bile_duct1.37868608
59MP0003436_decreased_susceptibility_to1.36916386
60MP0003984_embryonic_growth_retardation1.35619377
61MP0002092_abnormal_eye_morphology1.34634848
62MP0000026_abnormal_inner_ear1.32122336
63MP0001299_abnormal_eye_distance/1.30996088
64MP0002152_abnormal_brain_morphology1.30454476
65MP0002063_abnormal_learning/memory/cond1.24737970
66MP0004133_heterotaxia1.24712203
67MP0002638_abnormal_pupillary_reflex1.24623708
68MP0005319_abnormal_enzyme/_coenzyme1.23984702
69MP0010329_abnormal_lipoprotein_level1.23977393
70MP0003755_abnormal_palate_morphology1.21774655
71MP0002116_abnormal_craniofacial_bone1.20552967
72MP0000350_abnormal_cell_proliferation1.19413703
73MP0005023_abnormal_wound_healing1.18019297
74MP0002396_abnormal_hematopoietic_system1.16967079
75MP0003385_abnormal_body_wall1.14768307
76MP0002932_abnormal_joint_morphology1.14276049
77MP0009384_cardiac_valve_regurgitation1.14042823
78MP0002086_abnormal_extraembryonic_tissu1.13732088
79MP0002882_abnormal_neuron_morphology1.11796376
80MP0002233_abnormal_nose_morphology1.11093449
81MP0002184_abnormal_innervation1.10778632
82MP0001293_anophthalmia1.10562567
83MP0003115_abnormal_respiratory_system1.10506706
84MP0003077_abnormal_cell_cycle1.09861876
85MP0003937_abnormal_limbs/digits/tail_de1.09788975
86MP0003122_maternal_imprinting1.09601737
87MP0004381_abnormal_hair_follicle1.08947835
88MP0002734_abnormal_mechanical_nocicepti1.08162083
89MP0010030_abnormal_orbit_morphology1.07781979
90MP0005377_hearing/vestibular/ear_phenot1.06518651
91MP0003878_abnormal_ear_physiology1.06518651
92MP0000751_myopathy1.05577120
93MP0003634_abnormal_glial_cell1.04356766
94MP0005375_adipose_tissue_phenotype1.03641664
95MP0002970_abnormal_white_adipose1.02445993
96MP0005409_darkened_coat_color1.01640060
97MP0002081_perinatal_lethality1.01383242
98MP0003448_altered_tumor_morphology1.00715166
99MP0003283_abnormal_digestive_organ1.00712725
100MP0004811_abnormal_neuron_physiology1.00339949
101MP0005076_abnormal_cell_differentiation0.98718879
102MP0002572_abnormal_emotion/affect_behav0.98711308
103MP0003656_abnormal_erythrocyte_physiolo0.97795287
104MP0000598_abnormal_liver_morphology0.97635465
105MP0004233_abnormal_muscle_weight0.97129947
106MP0005248_abnormal_Harderian_gland0.96973291
107MP0001486_abnormal_startle_reflex0.96272413
108MP0000462_abnormal_digestive_system0.95664680
109MP0000678_abnormal_parathyroid_gland0.95099294
110MP0002098_abnormal_vibrissa_morphology0.94906537
111MP0002557_abnormal_social/conspecific_i0.94285142
112MP0003938_abnormal_ear_development0.93617618
113MP0005266_abnormal_metabolism0.93539462
114MP0004197_abnormal_fetal_growth/weight/0.93063114
115MP0002127_abnormal_cardiovascular_syste0.91575395
116MP0009672_abnormal_birth_weight0.90526492
117MP0000733_abnormal_muscle_development0.90506228
118MP0004130_abnormal_muscle_cell0.90423913
119MP0002132_abnormal_respiratory_system0.89971386
120MP0002111_abnormal_tail_morphology0.89516098
121MP0010368_abnormal_lymphatic_system0.89444470
122MP0005083_abnormal_biliary_tract0.89233845
123MP0002085_abnormal_embryonic_tissue0.88636263
124MP0008770_decreased_survivor_rate0.88309894
125MP0001502_abnormal_circadian_rhythm0.88232966
126MP0001340_abnormal_eyelid_morphology0.87895306
127MP0001286_abnormal_eye_development0.85803863
128MP0006276_abnormal_autonomic_nervous0.84806739
129MP0003121_genomic_imprinting0.84791497
130MP0001730_embryonic_growth_arrest0.83181914
131MP0002405_respiratory_system_inflammati0.82838580
132MP0000428_abnormal_craniofacial_morphol0.82808776
133MP0002752_abnormal_somatic_nervous0.81822037
134MP0003111_abnormal_nucleus_morphology0.81192027
135MP0000490_abnormal_crypts_of0.81027788
136MP0000432_abnormal_head_morphology0.80156011
137MP0001270_distended_abdomen0.79514822
138MP0002084_abnormal_developmental_patter0.79039808
139MP0005623_abnormal_meninges_morphology0.78677635
140MP0004885_abnormal_endolymph0.78479254
141MP0004185_abnormal_adipocyte_glucose0.78303450
142MP0000689_abnormal_spleen_morphology0.78282047
143MP0002735_abnormal_chemical_nociception0.77744816
144MP0000003_abnormal_adipose_tissue0.77553780
145MP0002733_abnormal_thermal_nociception0.77282691
146MP0000858_altered_metastatic_potential0.76986434
147MP0002722_abnormal_immune_system0.76119131
148MP0002277_abnormal_respiratory_mucosa0.76102115
149MP0005171_absent_coat_pigmentation0.74928426
150MP0003948_abnormal_gas_homeostasis0.74151349
151MP0000762_abnormal_tongue_morphology0.73724973
152MP0001800_abnormal_humoral_immune0.72674474
153MP0003119_abnormal_digestive_system0.72192016
154MP0000313_abnormal_cell_death0.71428911
155MP0002925_abnormal_cardiovascular_devel0.70583376
156MP0002080_prenatal_lethality0.70473723
157MP0000343_altered_response_to0.69784601
158MP0005410_abnormal_fertilization0.69390560
159MP0003303_peritoneal_inflammation0.69313536
160MP0003453_abnormal_keratinocyte_physiol0.69105162
161MP0009763_increased_sensitivity_to0.68362610
162MP0001697_abnormal_embryo_size0.68189457
163MP0001243_abnormal_dermal_layer0.67627102
164MP0004947_skin_inflammation0.67541888
165MP0008789_abnormal_olfactory_epithelium0.66109267
166MP0003566_abnormal_cell_adhesion0.65961696
167MP0003172_abnormal_lysosome_physiology0.65322113
168MP0009703_decreased_birth_body0.64969447
169MP0002019_abnormal_tumor_incidence0.64947214
170MP0005197_abnormal_uvea_morphology0.64734183
171MP0005391_vision/eye_phenotype0.64285598
172MP0003300_gastrointestinal_ulcer0.63814785
173MP0003935_abnormal_craniofacial_develop0.62941543
174MP0000377_abnormal_hair_follicle0.62250679
175MP0009764_decreased_sensitivity_to0.62157750

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.90001164
2Bilateral microphthalmos (HP:0007633)5.89504766
3Multiple enchondromatosis (HP:0005701)5.55207444
4Hepatoblastoma (HP:0002884)4.94596623
5Abnormality of the lower motor neuron (HP:0002366)4.48693018
6Rib fusion (HP:0000902)3.96789273
7Ependymoma (HP:0002888)3.55226323
8Abnormal cartilage morphology (HP:0002763)3.52337410
9Cortical dysplasia (HP:0002539)3.52139843
10Hypochromic anemia (HP:0001931)3.41481504
11Neoplasm of striated muscle (HP:0009728)3.22030059
12Abnormality of the intrinsic pathway (HP:0010989)3.11762108
13Turricephaly (HP:0000262)3.11036596
14Rhabdomyosarcoma (HP:0002859)2.99531613
15Nasal polyposis (HP:0100582)2.97179610
16Deep venous thrombosis (HP:0002625)2.93429045
17Hyperinsulinemic hypoglycemia (HP:0000825)2.90462070
18Upper motor neuron abnormality (HP:0002127)2.82131097
19Trigonocephaly (HP:0000243)2.81239925
20Hyperacusis (HP:0010780)2.80706496
21Amyotrophic lateral sclerosis (HP:0007354)2.79925978
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72502616
23Aplasia involving bones of the extremities (HP:0009825)2.71565777
24Aplasia involving bones of the upper limbs (HP:0009823)2.71565777
25Aplasia of the phalanges of the hand (HP:0009802)2.71565777
26Nephroblastoma (Wilms tumor) (HP:0002667)2.71296922
27Shallow orbits (HP:0000586)2.69822757
28Ragged-red muscle fibers (HP:0003200)2.67591405
29Pseudobulbar signs (HP:0002200)2.65134566
30Anomalous pulmonary venous return (HP:0010772)2.63877043
31Bronchomalacia (HP:0002780)2.63231425
32Reduced antithrombin III activity (HP:0001976)2.58569068
33Embryonal renal neoplasm (HP:0011794)2.57239542
34Abnormality of the nasal mucosa (HP:0000433)2.54129425
35Xanthomatosis (HP:0000991)2.53384408
36Renovascular hypertension (HP:0100817)2.53353776
37Hand muscle atrophy (HP:0009130)2.51597482
38Large earlobe (HP:0009748)2.51291095
39Fused cervical vertebrae (HP:0002949)2.51117201
40Abnormality of the aortic arch (HP:0012303)2.49585625
41Abnormality of the Achilles tendon (HP:0005109)2.47399610
42Skin nodule (HP:0200036)2.46636470
43Astrocytoma (HP:0009592)2.44854709
44Abnormality of the astrocytes (HP:0100707)2.44854709
45Hypoplasia of the fovea (HP:0007750)2.44560937
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.44560937
47Preauricular skin tag (HP:0000384)2.44202086
48Rectovaginal fistula (HP:0000143)2.42908948
49Rectal fistula (HP:0100590)2.42908948
50Testicular atrophy (HP:0000029)2.42022762
51Abnormality of the 4th metacarpal (HP:0010012)2.39692600
52Vaginal fistula (HP:0004320)2.38273981
53Tetraplegia (HP:0002445)2.38149648
54Impulsivity (HP:0100710)2.37612340
55Malnutrition (HP:0004395)2.37430311
56Abnormality of the salivary glands (HP:0010286)2.36841215
57Intrahepatic cholestasis (HP:0001406)2.34904577
58Achilles tendon contracture (HP:0001771)2.34303041
59Myokymia (HP:0002411)2.34191987
60Partial duplication of thumb phalanx (HP:0009944)2.33985077
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32515946
62Trismus (HP:0000211)2.31683316
63Skin tags (HP:0010609)2.29152136
64Peritonitis (HP:0002586)2.27994106
65High anterior hairline (HP:0009890)2.25601179
66Intestinal fistula (HP:0100819)2.24987745
67Combined immunodeficiency (HP:0005387)2.24803615
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24385550
69Short 4th metacarpal (HP:0010044)2.24385550
70Bifid tongue (HP:0010297)2.23678504
71Abnormality of the pulmonary veins (HP:0011718)2.23205696
72Split foot (HP:0001839)2.20046029
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18670209
74Renal dysplasia (HP:0000110)2.18059472
75Chromsome breakage (HP:0040012)2.15918123
76Abnormality of the phalanges of the hallux (HP:0010057)2.15387470
77Aplasia/Hypoplasia of the macula (HP:0008059)2.14971405
78Spastic diplegia (HP:0001264)2.14758189
79Pendular nystagmus (HP:0012043)2.13262925
80Elevated erythrocyte sedimentation rate (HP:0003565)2.12869006
81Partial duplication of the phalanx of hand (HP:0009999)2.07982474
82Choanal stenosis (HP:0000452)2.05212980
83Short 5th finger (HP:0009237)2.04242741
84Short humerus (HP:0005792)2.03666993
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00789688
86Retinal dysplasia (HP:0007973)2.00739641
87Increased serum ferritin (HP:0003281)2.00513063
88Renal duplication (HP:0000075)1.98781354
89Abnormality of the musculature of the hand (HP:0001421)1.98310273
90Broad distal phalanx of finger (HP:0009836)1.98306267
91Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98246972
92Hemivertebrae (HP:0002937)1.97804080
93Complement deficiency (HP:0004431)1.97711138
94Progressive sensorineural hearing impairment (HP:0000408)1.97457170
95Arnold-Chiari malformation (HP:0002308)1.96771418
96Difficulty running (HP:0009046)1.96727166
97Cheilitis (HP:0100825)1.95959812
98Aplasia/hypoplasia of the humerus (HP:0006507)1.95883996
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95350901
100Hypoplasia of the brainstem (HP:0002365)1.95350901
101Glossoptosis (HP:0000162)1.95240101
102Abnormal lung lobation (HP:0002101)1.94807638
103Upper limb amyotrophy (HP:0009129)1.94718963
104Distal upper limb amyotrophy (HP:0007149)1.94718963
105Villous atrophy (HP:0011473)1.93145008
106Abnormality of small intestinal villus morphology (HP:0011472)1.93145008
107Abnormality of iron homeostasis (HP:0011031)1.92815304
108Abnormality of the diencephalon (HP:0010662)1.92718367
109Septo-optic dysplasia (HP:0100842)1.91156644
110Abnormality of liposaccharide metabolism (HP:0010968)1.90729098
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.90729098
112Abnormality of glycolipid metabolism (HP:0010969)1.90729098
113Overriding aorta (HP:0002623)1.90329603
114Horizontal nystagmus (HP:0000666)1.89668934
115Spastic tetraparesis (HP:0001285)1.89408720
116Cutaneous finger syndactyly (HP:0010554)1.87217682
117Coronal craniosynostosis (HP:0004440)1.86789090
118Preauricular pit (HP:0004467)1.86219848
119Periauricular skin pits (HP:0100277)1.86219848
120Polyphagia (HP:0002591)1.86086939
121Thin ribs (HP:0000883)1.84944468
122Hypopigmentation of the fundus (HP:0007894)1.84892398
123Generalized hypotonia (HP:0001290)1.83835919
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.83320142
125Sensory axonal neuropathy (HP:0003390)1.83209861
126Megalocornea (HP:0000485)1.82578725
127Hypercholesterolemia (HP:0003124)1.82204442
128Drooling (HP:0002307)1.81380854
129Esophageal atresia (HP:0002032)1.81368060
130Bifid scrotum (HP:0000048)1.81197253
131Increased connective tissue (HP:0009025)1.81062860
132Abnormal biliary tract physiology (HP:0012439)1.80941206
133Bile duct proliferation (HP:0001408)1.80941206
134Abnormality of complement system (HP:0005339)1.79685502
135Cutaneous syndactyly (HP:0012725)1.79466562
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.78937201
137Hypoalphalipoproteinemia (HP:0003233)1.78424090
138Ulnar bowing (HP:0003031)1.78408509
139Precocious puberty (HP:0000826)1.78084650
140Vertebral arch anomaly (HP:0008438)1.77641046
141Vitreoretinal degeneration (HP:0000655)1.77550191
142Hyperglycinuria (HP:0003108)1.77413421
143Broad thumb (HP:0011304)1.77033983
144Vertebral clefting (HP:0008428)1.76672870
145Progressive muscle weakness (HP:0003323)1.76549533
146Congenital malformation of the right heart (HP:0011723)1.76435338
147Double outlet right ventricle (HP:0001719)1.76435338
148Elfin facies (HP:0004428)1.74014797
149Spina bifida occulta (HP:0003298)1.73476992
150Duplication of thumb phalanx (HP:0009942)1.73276741
151Insomnia (HP:0100785)1.72773609
152Renal hypoplasia (HP:0000089)1.72080668
153Broad phalanges of the hand (HP:0009768)1.69616743
154Hammertoe (HP:0001765)1.69067653
155Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68281472
156Abnormality of the parathyroid morphology (HP:0011766)1.65858392
157Oligodactyly (HP:0012165)1.65286637
158Preaxial foot polydactyly (HP:0001841)1.65169439
159Myelomeningocele (HP:0002475)1.64113932
160Truncal ataxia (HP:0002078)1.63848893
161Bicornuate uterus (HP:0000813)1.62901516
162Anophthalmia (HP:0000528)1.61853150
163Broad finger (HP:0001500)1.60929897
164Ankle clonus (HP:0011448)1.60831920
165Excessive salivation (HP:0003781)1.60458291
166Megalencephaly (HP:0001355)1.60316243
167Pointed chin (HP:0000307)1.59558721
168Peripheral hypomyelination (HP:0007182)1.58516404
169Morphological abnormality of the middle ear (HP:0008609)1.58454803
170Long palpebral fissure (HP:0000637)1.56849034
171Laryngomalacia (HP:0001601)1.56457265
172Humeroradial synostosis (HP:0003041)1.56200181
173Synostosis involving the elbow (HP:0003938)1.56200181
174Omphalocele (HP:0001539)1.55922529
175Failure to thrive in infancy (HP:0001531)1.53870641
176Intellectual disability, moderate (HP:0002342)1.53658310
177Meningocele (HP:0002435)1.53361241
178Bowel incontinence (HP:0002607)1.53142341
179Broad metatarsal (HP:0001783)1.51244263
180Spastic gait (HP:0002064)1.50059625
181Difficulty climbing stairs (HP:0003551)1.49682881
182Neonatal short-limb short stature (HP:0008921)1.48478188
183Short palpebral fissure (HP:0012745)1.47598234
184Maternal diabetes (HP:0009800)1.47161307
185Shawl scrotum (HP:0000049)1.46369894
186Down-sloping shoulders (HP:0200021)1.46078785
187Carpal synostosis (HP:0009702)1.45504512
188Broad face (HP:0000283)1.45422745
189Obsessive-compulsive behavior (HP:0000722)1.45022964
190Increased nuchal translucency (HP:0010880)1.43193156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.16208772
2ERN15.26220570
3GRK64.07766873
4GRK53.60502543
5MARK13.41317395
6PRKD33.31074329
7CASK3.23334868
8CSF1R2.97594376
9TGFBR22.91238382
10NTRK22.81061250
11TYRO32.66356631
12STK102.65028211
13MAP3K102.46851166
14GRK12.39188983
15ADRBK22.19143823
16TESK12.10291277
17TTK2.04433242
18MAP2K71.96503403
19MATK1.90819547
20EPHB21.87847536
21MAPK71.83561718
22BCR1.67474900
23CAMK1G1.66956078
24MOS1.66318342
25GRK71.63233754
26EPHA31.56564305
27DDR21.54732422
28TRIB31.51213434
29CDK191.46940167
30BRD41.40654708
31MAP3K41.31835520
32PAK41.30342265
33FGFR31.26203787
34RPS6KA21.23905631
35MAPK151.19599652
36CAMK41.19301177
37CDK71.18363201
38SIK11.17184593
39ITK1.14559509
40MAP3K91.13571103
41CSK1.08753101
42NTRK11.07379454
43MAP4K11.05804716
44CSNK1A1L1.02265081
45SGK2231.01884801
46SGK4941.01884801
47PAK61.01551901
48CSNK1G21.01392463
49WNK11.00910836
50EPHB11.00517566
51EEF2K1.00190656
52FGFR40.99530675
53MARK20.99453282
54PRKG20.97250541
55CSNK1G30.96853746
56SMG10.94538590
57KSR20.90622410
58HIPK20.89734891
59PKN20.86722388
60NEK20.85237342
61CHEK20.85010350
62ICK0.84477071
63BMX0.83734206
64PLK40.82623984
65DYRK1B0.82347804
66LATS10.79495158
67TTN0.79126933
68CSNK1G10.78903844
69CAMKK10.78702557
70MTOR0.78148686
71STK38L0.77769907
72PNCK0.77169054
73BCKDK0.76787222
74MAP2K20.75005986
75MAP2K40.75001735
76FGFR20.74525676
77RPS6KA40.73473632
78TYK20.72913980
79CDK40.72390268
80MAPK120.72196556
81PDGFRA0.71120940
82MAP2K60.70996158
83EPHA20.70832930
84PHKG20.70235007
85PHKG10.70235007
86PTK20.68831775
87ADRBK10.68203526
88RPS6KC10.68012380
89RPS6KL10.68012380
90UHMK10.67581183
91PLK10.66168207
92LMTK20.66122718
93ERBB20.65432361
94MAP2K30.64058981
95ALK0.63375273
96RPS6KA10.63027891
97STK380.61343236
98PRKCZ0.59707933
99MAPK130.59527340
100CDK50.59409149
101ARAF0.59051662
102CDK11A0.58924661
103MAP3K70.58000871
104PKN10.56779113
105KIT0.56282876
106PRPF4B0.55770120
107KSR10.55658070
108CHEK10.54630104
109TAOK10.54456744
110IGF1R0.54198044
111SGK20.54148711
112RIPK10.53756803
113MAP3K30.53448681
114PRKAA10.53317801
115MST1R0.51561299
116CAMK2B0.51107303
117ROCK20.51008227
118AKT20.50786135
119CDK140.50541979
120INSRR0.50211822
121RET0.50203614
122LATS20.49852157
123NEK60.49749265
124NTRK30.49679410
125BLK0.49057610
126RPS6KA60.48033434
127CAMK2G0.47251389
128CAMK1D0.47008060
129EPHA40.46795214
130PRKD20.45517256
131HCK0.45429799
132TBK10.44993650
133MAPK110.44945862
134RPS6KB20.44866040
135GSK3A0.44703740
136MAPK100.44548928
137CDK150.44411416
138MAPKAPK30.43516061
139LRRK20.42582108
140PTK60.42139671
141ZAP700.42057581
142CDK180.41405916
143IKBKB0.41304585
144CDC70.41102590
145SGK30.40784150
146DYRK1A0.40290428
147TNIK0.40180739
148MAP3K80.38299954
149MAPK40.38215465
150JAK20.37984237
151EIF2AK20.36796467
152CDK60.36550854
153EGFR0.35969618
154SIK20.35826596
155KDR0.35646395
156DYRK20.35079210
157PIM10.34515067
158ERBB40.34469066
159CDK20.34216758
160CHUK0.32806863
161STK30.31720873
162AURKA0.31042293
163FLT30.29680402
164LCK0.29463795
165INSR0.28852233
166MELK0.28368245
167STK40.28012556
168PAK20.27178432
169PRKCD0.25338307
170DYRK30.23490068

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.53317788
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.10791258
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.69293389
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.60348870
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.59222067
6Complement and coagulation cascades_Homo sapiens_hsa046102.51292526
7Fructose and mannose metabolism_Homo sapiens_hsa000512.27844945
8Nitrogen metabolism_Homo sapiens_hsa009102.23262978
9Fatty acid biosynthesis_Homo sapiens_hsa000612.19146063
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12444091
11Tryptophan metabolism_Homo sapiens_hsa003801.97312361
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.95526405
13Chemical carcinogenesis_Homo sapiens_hsa052041.85714110
14Axon guidance_Homo sapiens_hsa043601.83777567
15Staphylococcus aureus infection_Homo sapiens_hsa051501.74953425
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72763854
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71135529
18Selenocompound metabolism_Homo sapiens_hsa004501.68736486
19Arginine biosynthesis_Homo sapiens_hsa002201.66365751
20Hippo signaling pathway_Homo sapiens_hsa043901.60411711
21Galactose metabolism_Homo sapiens_hsa000521.60104500
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53004244
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51483390
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49767209
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45286793
26Hedgehog signaling pathway_Homo sapiens_hsa043401.40476298
27One carbon pool by folate_Homo sapiens_hsa006701.40076356
28PPAR signaling pathway_Homo sapiens_hsa033201.39323794
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39188402
30Caffeine metabolism_Homo sapiens_hsa002321.33491820
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33111331
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30181717
33Nicotine addiction_Homo sapiens_hsa050331.29151552
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29019046
35Endometrial cancer_Homo sapiens_hsa052131.26385763
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.24217896
37Folate biosynthesis_Homo sapiens_hsa007901.23408007
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23300778
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22716906
40Retinol metabolism_Homo sapiens_hsa008301.22052200
41Sulfur relay system_Homo sapiens_hsa041221.21756591
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18320404
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17924631
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17756981
45Fatty acid degradation_Homo sapiens_hsa000711.17139794
46Linoleic acid metabolism_Homo sapiens_hsa005911.15822091
47Adherens junction_Homo sapiens_hsa045201.14455050
48Pentose phosphate pathway_Homo sapiens_hsa000301.12229192
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12204707
50Arginine and proline metabolism_Homo sapiens_hsa003301.10423481
51Prion diseases_Homo sapiens_hsa050201.09316762
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.07794082
53Arachidonic acid metabolism_Homo sapiens_hsa005901.04320909
54Biosynthesis of amino acids_Homo sapiens_hsa012301.03932990
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03925535
56Colorectal cancer_Homo sapiens_hsa052101.02435346
57Cocaine addiction_Homo sapiens_hsa050301.02389773
58ErbB signaling pathway_Homo sapiens_hsa040121.02338078
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01291374
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01062294
61mTOR signaling pathway_Homo sapiens_hsa041501.00437895
62Gap junction_Homo sapiens_hsa045400.99933249
63Melanogenesis_Homo sapiens_hsa049160.99870200
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98925136
65GABAergic synapse_Homo sapiens_hsa047270.98886907
66Bile secretion_Homo sapiens_hsa049760.97027253
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96654086
68Tight junction_Homo sapiens_hsa045300.95454987
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95137570
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94802770
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94327503
72Wnt signaling pathway_Homo sapiens_hsa043100.92316443
73Carbon metabolism_Homo sapiens_hsa012000.90871942
74Insulin signaling pathway_Homo sapiens_hsa049100.90746961
75Lysine degradation_Homo sapiens_hsa003100.89685033
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.87146758
77Estrogen signaling pathway_Homo sapiens_hsa049150.85682413
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83801660
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83776012
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83685052
81Pyruvate metabolism_Homo sapiens_hsa006200.80660643
82ABC transporters_Homo sapiens_hsa020100.80025009
83Thyroid cancer_Homo sapiens_hsa052160.80005086
84Dilated cardiomyopathy_Homo sapiens_hsa054140.78422274
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.77408316
86Cholinergic synapse_Homo sapiens_hsa047250.75194721
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74264693
88Histidine metabolism_Homo sapiens_hsa003400.74235425
89Fatty acid metabolism_Homo sapiens_hsa012120.74111358
90Acute myeloid leukemia_Homo sapiens_hsa052210.74036426
91Glutamatergic synapse_Homo sapiens_hsa047240.73359960
92Type II diabetes mellitus_Homo sapiens_hsa049300.71534922
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71392575
94Choline metabolism in cancer_Homo sapiens_hsa052310.71121366
95Peroxisome_Homo sapiens_hsa041460.69719267
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69393352
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.67572863
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67069354
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.66846173
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.66669613
101Dopaminergic synapse_Homo sapiens_hsa047280.66489504
102Alcoholism_Homo sapiens_hsa050340.66443898
103cAMP signaling pathway_Homo sapiens_hsa040240.63923747
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63316447
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62921628
106Chronic myeloid leukemia_Homo sapiens_hsa052200.62668540
107Glioma_Homo sapiens_hsa052140.62459576
108Circadian entrainment_Homo sapiens_hsa047130.62098049
109Fat digestion and absorption_Homo sapiens_hsa049750.59757288
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59146638
111Morphine addiction_Homo sapiens_hsa050320.58557918
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57786234
113Bladder cancer_Homo sapiens_hsa052190.57727753
114beta-Alanine metabolism_Homo sapiens_hsa004100.56250120
115B cell receptor signaling pathway_Homo sapiens_hsa046620.56090922
116RNA transport_Homo sapiens_hsa030130.55339070
117MicroRNAs in cancer_Homo sapiens_hsa052060.55226395
118Non-small cell lung cancer_Homo sapiens_hsa052230.54656920
119Apoptosis_Homo sapiens_hsa042100.54602227
120Fatty acid elongation_Homo sapiens_hsa000620.53719768
121Rap1 signaling pathway_Homo sapiens_hsa040150.53356234
122Starch and sucrose metabolism_Homo sapiens_hsa005000.52540251
123Prostate cancer_Homo sapiens_hsa052150.52407194
124Butanoate metabolism_Homo sapiens_hsa006500.51634989
125T cell receptor signaling pathway_Homo sapiens_hsa046600.51379141
126Insulin secretion_Homo sapiens_hsa049110.50463272
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50238902
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50220429
129VEGF signaling pathway_Homo sapiens_hsa043700.50125033
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.49864820
131Notch signaling pathway_Homo sapiens_hsa043300.49455805
132Glycerolipid metabolism_Homo sapiens_hsa005610.49452361
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.49290557
134Leishmaniasis_Homo sapiens_hsa051400.48815871
135AMPK signaling pathway_Homo sapiens_hsa041520.48639129
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48397430
137Prolactin signaling pathway_Homo sapiens_hsa049170.47910789
138Focal adhesion_Homo sapiens_hsa045100.47310683
139ECM-receptor interaction_Homo sapiens_hsa045120.47251961
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47185867
141Other glycan degradation_Homo sapiens_hsa005110.46231563
142Herpes simplex infection_Homo sapiens_hsa051680.46180997
143Phenylalanine metabolism_Homo sapiens_hsa003600.45894463
144Insulin resistance_Homo sapiens_hsa049310.45773268
145Renal cell carcinoma_Homo sapiens_hsa052110.45700332
146Base excision repair_Homo sapiens_hsa034100.45542152
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44955731
148Tyrosine metabolism_Homo sapiens_hsa003500.44655953
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42940177
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.42130501
151p53 signaling pathway_Homo sapiens_hsa041150.41699851
152Pancreatic cancer_Homo sapiens_hsa052120.41697903
153mRNA surveillance pathway_Homo sapiens_hsa030150.40518833
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39379874
155DNA replication_Homo sapiens_hsa030300.36194457
156Basal cell carcinoma_Homo sapiens_hsa052170.35717554
157Proteoglycans in cancer_Homo sapiens_hsa052050.35534016
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.34185111
159Primary immunodeficiency_Homo sapiens_hsa053400.34113061
160Cell cycle_Homo sapiens_hsa041100.33934395
161Steroid biosynthesis_Homo sapiens_hsa001000.32901534
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32859413
163Hepatitis C_Homo sapiens_hsa051600.32158209
164Malaria_Homo sapiens_hsa051440.31805504

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