KLHL26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.66557638
2synaptic vesicle maturation (GO:0016188)4.73956524
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52406530
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.42149244
5gamma-aminobutyric acid transport (GO:0015812)4.39829880
6locomotory exploration behavior (GO:0035641)4.29104568
7glutamate secretion (GO:0014047)4.07930156
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03117203
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.97255090
10glycerophospholipid catabolic process (GO:0046475)3.82636778
11pyrimidine nucleobase catabolic process (GO:0006208)3.82363915
12fucose catabolic process (GO:0019317)3.81941393
13L-fucose metabolic process (GO:0042354)3.81941393
14L-fucose catabolic process (GO:0042355)3.81941393
15positive regulation of fibroblast migration (GO:0010763)3.81163430
16vocalization behavior (GO:0071625)3.80617137
17synaptic vesicle exocytosis (GO:0016079)3.80110869
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.73702603
19axon extension involved in axon guidance (GO:0048846)3.73702603
20regulation of synapse structural plasticity (GO:0051823)3.71370435
21negative regulation of telomere maintenance (GO:0032205)3.68641437
22negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68529247
23sodium ion export (GO:0071436)3.67917866
24layer formation in cerebral cortex (GO:0021819)3.67080547
25neuron cell-cell adhesion (GO:0007158)3.63701959
26regulation of synaptic vesicle exocytosis (GO:2000300)3.59411093
27positive regulation of vesicle fusion (GO:0031340)3.48785336
28positive regulation of synapse maturation (GO:0090129)3.45584374
29retinal cone cell development (GO:0046549)3.45320313
30postsynaptic membrane organization (GO:0001941)3.40188476
31exploration behavior (GO:0035640)3.39773243
32plasma membrane repair (GO:0001778)3.39534079
33piRNA metabolic process (GO:0034587)3.39480502
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34067529
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33845137
36protein-cofactor linkage (GO:0018065)3.33351551
37stress fiber assembly (GO:0043149)3.28286269
38protein localization to cilium (GO:0061512)3.28254336
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27289491
40activation of protein kinase A activity (GO:0034199)3.27147567
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24870114
42regulation of neuronal synaptic plasticity (GO:0048168)3.23431644
43cell communication by electrical coupling (GO:0010644)3.23212538
44protein targeting to plasma membrane (GO:0072661)3.17473071
45nucleobase catabolic process (GO:0046113)3.16986706
46protein localization to synapse (GO:0035418)3.15492229
47regulation of glutamate receptor signaling pathway (GO:1900449)3.15154021
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15074061
49establishment of mitochondrion localization (GO:0051654)3.14873443
50negative regulation of microtubule polymerization (GO:0031115)3.13778402
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13682118
52response to pheromone (GO:0019236)3.13319835
53signal complex assembly (GO:0007172)3.13019263
54cerebellar Purkinje cell layer development (GO:0021680)3.12458298
55regulation of synaptic vesicle transport (GO:1902803)3.09649848
56positive regulation of axon extension (GO:0045773)3.08989873
57neurotransmitter secretion (GO:0007269)3.06180330
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04980848
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.04980848
60NADH dehydrogenase complex assembly (GO:0010257)3.04980848
61cAMP catabolic process (GO:0006198)3.03649630
62protein complex biogenesis (GO:0070271)3.03060309
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.02190179
64transmission of nerve impulse (GO:0019226)3.01684043
65DNA methylation involved in gamete generation (GO:0043046)3.01150452
66establishment of nucleus localization (GO:0040023)3.00169500
67neuronal action potential propagation (GO:0019227)2.99893036
68regulation of early endosome to late endosome transport (GO:2000641)2.96729813
69negative regulation of fatty acid transport (GO:2000192)2.96298303
70neuromuscular process controlling balance (GO:0050885)2.96113056
71protein retention in ER lumen (GO:0006621)2.91230698
72synaptic transmission, cholinergic (GO:0007271)2.91100787
73neuromuscular synaptic transmission (GO:0007274)2.89310750
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88790212
75mitochondrial respiratory chain complex assembly (GO:0033108)2.86372821
76proline transport (GO:0015824)2.86163066
77sequestering of extracellular ligand from receptor (GO:0035581)2.85509277
78regulation of vesicle fusion (GO:0031338)2.85435135
79adherens junction assembly (GO:0034333)2.85371128
80nonmotile primary cilium assembly (GO:0035058)2.84464333
81positive regulation of triglyceride biosynthetic process (GO:0010867)2.82876521
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82736789
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81356938
84protein heterotrimerization (GO:0070208)2.81165333
85negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79981387
86kynurenine metabolic process (GO:0070189)2.79739192
87energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.79527744
88ATP hydrolysis coupled proton transport (GO:0015991)2.79527744
89cellular ketone body metabolic process (GO:0046950)2.79213960
90indole-containing compound catabolic process (GO:0042436)2.78044604
91indolalkylamine catabolic process (GO:0046218)2.78044604
92tryptophan catabolic process (GO:0006569)2.78044604
93regulation of neurotransmitter levels (GO:0001505)2.77633304
94DNA deamination (GO:0045006)2.77576315
95ionotropic glutamate receptor signaling pathway (GO:0035235)2.76128036
96axon extension (GO:0048675)2.74485650
97barbed-end actin filament capping (GO:0051016)2.73755124
98cellular response to ATP (GO:0071318)2.73310792
99peptidyl-proline hydroxylation (GO:0019511)2.72316722
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71632456
101substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.71376433
102substrate-independent telencephalic tangential migration (GO:0021826)2.71376433
103epithelial cilium movement (GO:0003351)2.70338185
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69066233
105innervation (GO:0060384)2.68371607
106regulation of tight junction assembly (GO:2000810)2.68101170
107cyclic nucleotide catabolic process (GO:0009214)2.68069311
108startle response (GO:0001964)2.67980808
109behavioral defense response (GO:0002209)2.66857363
110behavioral fear response (GO:0001662)2.66857363
111neuron fate determination (GO:0048664)2.66544241
112cellular potassium ion homeostasis (GO:0030007)2.66185036
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.65953353
114membrane depolarization during action potential (GO:0086010)2.64734746
115positive regulation of meiosis (GO:0045836)2.64598145
116primary amino compound metabolic process (GO:1901160)2.63814604
117glycine transport (GO:0015816)2.63016793
118regulation of rhodopsin mediated signaling pathway (GO:0022400)2.62789696
119regulation of action potential (GO:0098900)2.62505289
120dendritic spine morphogenesis (GO:0060997)2.61877090
121multicellular organism reproduction (GO:0032504)2.60633999
122dermatan sulfate biosynthetic process (GO:0030208)2.60102969
123serotonin receptor signaling pathway (GO:0007210)2.59427446
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.59192837
125COPI coating of Golgi vesicle (GO:0048205)2.58996046
126Golgi transport vesicle coating (GO:0048200)2.58996046
127positive regulation of mitochondrial fission (GO:0090141)2.58715973
128neuronal action potential (GO:0019228)2.58001710
129synaptic vesicle endocytosis (GO:0048488)2.57704703
130cell migration in hindbrain (GO:0021535)2.57654286
131positive regulation of fatty acid transport (GO:2000193)2.57409367
132platelet dense granule organization (GO:0060155)2.57360375
133indole-containing compound metabolic process (GO:0042430)2.57329847
134positive regulation of synaptic transmission, GABAergic (GO:0032230)2.57061907
135ubiquinone metabolic process (GO:0006743)2.55276297
136auditory behavior (GO:0031223)2.55263939
137negative regulation of cell size (GO:0045792)2.54161118
138regulation of synaptic plasticity (GO:0048167)2.53580017
139negative regulation of cAMP-mediated signaling (GO:0043951)2.53453326
140rhodopsin mediated signaling pathway (GO:0016056)2.53261011
141regulation of ARF protein signal transduction (GO:0032012)2.52558610
142regulation of neurotransmitter uptake (GO:0051580)2.52528382
143regulation of respiratory system process (GO:0044065)2.52310013
144auditory receptor cell stereocilium organization (GO:0060088)2.52082029
145vesicle transport along microtubule (GO:0047496)2.51807439
146neuron projection extension (GO:1990138)2.51717224
147synaptic transmission, glutamatergic (GO:0035249)2.51338097
148neurotransmitter metabolic process (GO:0042133)2.51120219
149mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51030679
150indolalkylamine metabolic process (GO:0006586)2.50817482
151mannosylation (GO:0097502)2.50529371
152regulation of clathrin-mediated endocytosis (GO:2000369)2.50493523
153ubiquinone biosynthetic process (GO:0006744)2.49799525
154regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48705126
155neuron-neuron synaptic transmission (GO:0007270)2.47657262
156chondrocyte proliferation (GO:0035988)2.46800850
157positive regulation of prostaglandin secretion (GO:0032308)2.46714508
158focal adhesion assembly (GO:0048041)2.46325903
159cell-substrate adherens junction assembly (GO:0007045)2.46325903
160collagen fibril organization (GO:0030199)2.46324862
161heparan sulfate proteoglycan metabolic process (GO:0030201)2.45375653
162response to amphetamine (GO:0001975)2.44824134
163regulation of axon extension (GO:0030516)2.44159262
164inner ear receptor stereocilium organization (GO:0060122)2.44006144
165cerebellar Purkinje cell differentiation (GO:0021702)2.43867582
166negative regulation of adherens junction organization (GO:1903392)2.43827496
167negative regulation of focal adhesion assembly (GO:0051895)2.43827496
168negative regulation of cell junction assembly (GO:1901889)2.43827496
169ketone body metabolic process (GO:1902224)2.43721937
170protein hydroxylation (GO:0018126)2.43444362
171serotonin metabolic process (GO:0042428)2.43130357
172heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.41607386
173peptidyl-tyrosine autophosphorylation (GO:0038083)2.41328115
174dermatan sulfate metabolic process (GO:0030205)2.40251686
175dendrite morphogenesis (GO:0048813)2.39454061
176neurotransmitter-gated ion channel clustering (GO:0072578)2.39451032
177glutamate receptor signaling pathway (GO:0007215)2.38059998
178regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.37113905
179actin filament capping (GO:0051693)2.36777903
180positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36740840
181actin filament bundle assembly (GO:0051017)2.36102715
182actin filament bundle organization (GO:0061572)2.36102715
183regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35563251
184regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.34191387
185positive regulation of dendrite morphogenesis (GO:0050775)2.32837369
186response to auditory stimulus (GO:0010996)2.32696479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.14744375
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96693547
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.89213303
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.77037579
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.65854157
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.57589294
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38223452
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36970386
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36539989
10VDR_22108803_ChIP-Seq_LS180_Human2.29976682
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27684576
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.27553772
13* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26447789
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26039486
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26039486
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.24816392
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23573311
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18220037
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17387869
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.17322768
21* DROSHA_22980978_ChIP-Seq_HELA_Human2.12615099
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09355627
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09287215
24KDM2B_26808549_Chip-Seq_K562_Human2.03024557
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02278357
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00219077
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97004616
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95432101
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92102482
30LXR_22292898_ChIP-Seq_THP-1_Human1.91564290
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91408552
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.90970179
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.90918530
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.84763943
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81530227
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80837040
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.80102080
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79537566
39* TP53_20018659_ChIP-ChIP_R1E_Mouse1.78708653
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.77160516
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73120048
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73057145
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.72273025
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.72011292
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69834198
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66498779
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66372051
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65544787
49IRF1_19129219_ChIP-ChIP_H3396_Human1.63450962
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.63190465
51KDM2B_26808549_Chip-Seq_DND41_Human1.61309346
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61244019
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60997126
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59947730
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.57175935
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56765257
57RNF2_27304074_Chip-Seq_NSC_Mouse1.54078504
58REST_18959480_ChIP-ChIP_MESCs_Mouse1.51149095
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51039512
60* TP53_23651856_ChIP-Seq_MEFs_Mouse1.50512188
61MYC_18940864_ChIP-ChIP_HL60_Human1.48895244
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.47804959
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.47780193
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46149281
65CLOCK_20551151_ChIP-Seq_293T_Human1.45958426
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.44182669
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42137746
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41683752
69IGF1R_20145208_ChIP-Seq_DFB_Human1.41310931
70* REST_21632747_ChIP-Seq_MESCs_Mouse1.41018461
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40349456
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.40249551
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39520110
74RACK7_27058665_Chip-Seq_MCF-7_Human1.38779472
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37514931
76TP53_22573176_ChIP-Seq_HFKS_Human1.37029988
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36028653
78ERA_21632823_ChIP-Seq_H3396_Human1.35703460
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.34082732
80ZNF263_19887448_ChIP-Seq_K562_Human1.32962519
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32466536
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31702935
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31519097
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.31255759
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28766449
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28766449
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26759245
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.26700056
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26415370
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25375409
91ETS1_20019798_ChIP-Seq_JURKAT_Human1.23883890
92TP53_16413492_ChIP-PET_HCT116_Human1.22998322
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22283848
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22160698
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21340538
96TP53_22127205_ChIP-Seq_IMR90_Human1.21145168
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20802523
98GATA3_21878914_ChIP-Seq_MCF-7_Human1.20525955
99* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20333105
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20330046
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.20236097
102CREB1_26743006_Chip-Seq_LNCaP_Human1.19380568
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18867482
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.17908251
105MYC_19829295_ChIP-Seq_ESCs_Human1.17251467
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.16880293
107* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16787420
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16685267
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15897473
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15314203
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13560309
112* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13545973
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12697960
114TAF2_19829295_ChIP-Seq_ESCs_Human1.12427283
115ATF3_27146783_Chip-Seq_COLON_Human1.11456230
116GBX2_23144817_ChIP-Seq_PC3_Human1.10686480
117ER_23166858_ChIP-Seq_MCF-7_Human1.07557470
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07272152
119NCOR_22424771_ChIP-Seq_293T_Human1.07214972
120OCT4_19829295_ChIP-Seq_ESCs_Human1.07167429
121RING1B_27294783_Chip-Seq_NPCs_Mouse1.05890336
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05774029
123OCT4_20526341_ChIP-Seq_ESCs_Human1.05711835
124P300_19829295_ChIP-Seq_ESCs_Human1.04969545
125* SMC4_20622854_ChIP-Seq_HELA_Human1.03590510
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03531789
127AR_25329375_ChIP-Seq_VCAP_Human1.03303350
128ELF1_20517297_ChIP-Seq_JURKAT_Human1.02289610
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.01798839
130TP63_19390658_ChIP-ChIP_HaCaT_Human1.01419124
131CTCF_27219007_Chip-Seq_Bcells_Human1.01397183
132SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01236486
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.00770736
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00373131
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98230868
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97776787
137* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97413042
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97361630
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96737574
140AR_21572438_ChIP-Seq_LNCaP_Human0.96062110
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96041467
142EWS_26573619_Chip-Seq_HEK293_Human0.95784935
143NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95639884
144ZNF274_21170338_ChIP-Seq_K562_Hela0.95553144
145* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95516928
146HOXB7_26014856_ChIP-Seq_BT474_Human0.94855596
147RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94202787
148RAC3_21632823_ChIP-Seq_H3396_Human0.93582074
149AR_19668381_ChIP-Seq_PC3_Human0.93246471
150KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92480794
151VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92480226
152* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92453579
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91720042
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.91720042
155TAF15_26573619_Chip-Seq_HEK293_Human0.90434101
156AR_20517297_ChIP-Seq_VCAP_Human0.90377763
157RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89851798
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89821562
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.89607555
160* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89593642
161PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88888679
162SA1_27219007_Chip-Seq_ERYTHROID_Human0.87262344
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86789324
164NANOG_20526341_ChIP-Seq_ESCs_Human0.86585353
165PHF8_20622854_ChIP-Seq_HELA_Human0.85918782
166TCF4_23295773_ChIP-Seq_U87_Human0.84169308
167BCAT_22108803_ChIP-Seq_LS180_Human0.83804944
168RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82972568
169VDR_23849224_ChIP-Seq_CD4+_Human0.82807159

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.00485218
2MP0008438_abnormal_cutaneous_collagen3.97524453
3MP0003705_abnormal_hypodermis_morpholog3.12915949
4MP0005623_abnormal_meninges_morphology2.89689507
5MP0003635_abnormal_synaptic_transmissio2.83242643
6MP0003279_aneurysm2.81031749
7MP0005275_abnormal_skin_tensile2.59357473
8MP0006292_abnormal_olfactory_placode2.59277537
9MP0004858_abnormal_nervous_system2.54212961
10MP0008877_abnormal_DNA_methylation2.52595037
11MP0005503_abnormal_tendon_morphology2.41031605
12MP0004270_analgesia2.31056336
13MP0003136_yellow_coat_color2.28523609
14MP0000013_abnormal_adipose_tissue2.27829977
15MP0001968_abnormal_touch/_nociception2.18272394
16MP0002063_abnormal_learning/memory/cond2.18131316
17MP0009780_abnormal_chondrocyte_physiolo2.17956466
18MP0004742_abnormal_vestibular_system2.07242824
19MP0008961_abnormal_basal_metabolism2.07182460
20MP0005645_abnormal_hypothalamus_physiol1.98143244
21MP0002638_abnormal_pupillary_reflex1.98017999
22MP0002736_abnormal_nociception_after1.97927967
23MP0004142_abnormal_muscle_tone1.97119013
24MP0000751_myopathy1.92863911
25MP0003787_abnormal_imprinting1.90678359
26MP0001348_abnormal_lacrimal_gland1.90296342
27MP0003283_abnormal_digestive_organ1.88569310
28MP0000566_synostosis1.88182568
29MP0002735_abnormal_chemical_nociception1.87298444
30MP0009745_abnormal_behavioral_response1.84203318
31MP0005551_abnormal_eye_electrophysiolog1.83493901
32MP0003880_abnormal_central_pattern1.83344722
33MP0001958_emphysema1.82932288
34MP0004233_abnormal_muscle_weight1.79364711
35MP0002102_abnormal_ear_morphology1.76588499
36MP0002064_seizures1.73108566
37MP0001986_abnormal_taste_sensitivity1.73006860
38MP0001502_abnormal_circadian_rhythm1.70128836
39MP0005646_abnormal_pituitary_gland1.69887179
40MP0008875_abnormal_xenobiotic_pharmacok1.65226625
41MP0004811_abnormal_neuron_physiology1.61761018
42MP0003091_abnormal_cell_migration1.61328561
43MP0002909_abnormal_adrenal_gland1.59426309
44MP0010352_gastrointestinal_tract_polyps1.58799357
45MP0010234_abnormal_vibrissa_follicle1.58245008
46MP0002734_abnormal_mechanical_nocicepti1.55259538
47MP0000631_abnormal_neuroendocrine_gland1.54653330
48MP0003329_amyloid_beta_deposits1.52088459
49MP0002572_abnormal_emotion/affect_behav1.49738366
50MP0003566_abnormal_cell_adhesion1.46996218
51MP0004043_abnormal_pH_regulation1.44877738
52MP0002733_abnormal_thermal_nociception1.44471642
53MP0010030_abnormal_orbit_morphology1.43153977
54MP0001485_abnormal_pinna_reflex1.40920494
55MP0001299_abnormal_eye_distance/1.40614859
56MP0003122_maternal_imprinting1.40336748
57MP0008995_early_reproductive_senescence1.40008859
58MP0003879_abnormal_hair_cell1.36955564
59MP0002089_abnormal_postnatal_growth/wei1.34040255
60MP0001905_abnormal_dopamine_level1.32623197
61MP0000955_abnormal_spinal_cord1.31866436
62MP0000534_abnormal_ureter_morphology1.30937209
63MP0002184_abnormal_innervation1.30581047
64MP0001970_abnormal_pain_threshold1.28303831
65MP0003646_muscle_fatigue1.28130709
66MP0009046_muscle_twitch1.26739124
67MP0001440_abnormal_grooming_behavior1.25929279
68MP0004924_abnormal_behavior1.25475618
69MP0005386_behavior/neurological_phenoty1.25475618
70MP0003195_calcinosis1.25345971
71MP0008872_abnormal_physiological_respon1.25262353
72MP0000026_abnormal_inner_ear1.24188331
73MP0002876_abnormal_thyroid_physiology1.23738686
74MP0002822_catalepsy1.23730999
75MP0005499_abnormal_olfactory_system1.22001899
76MP0005394_taste/olfaction_phenotype1.22001899
77MP0000003_abnormal_adipose_tissue1.20971736
78MP0002272_abnormal_nervous_system1.18701129
79MP0005023_abnormal_wound_healing1.17836861
80MP0001529_abnormal_vocalization1.17723519
81MP0002295_abnormal_pulmonary_circulatio1.17602598
82MP0001963_abnormal_hearing_physiology1.14971791
83MP0002896_abnormal_bone_mineralization1.14721084
84MP0001984_abnormal_olfaction1.14418894
85MP0003121_genomic_imprinting1.12506709
86MP0002234_abnormal_pharynx_morphology1.11175326
87MP0000747_muscle_weakness1.10738233
88MP0005253_abnormal_eye_physiology1.09437293
89MP0003045_fibrosis1.08477096
90MP0002877_abnormal_melanocyte_morpholog1.06412764
91MP0002163_abnormal_gland_morphology1.06015576
92MP0008569_lethality_at_weaning1.05011696
93MP0000759_abnormal_skeletal_muscle1.03392980
94MP0004272_abnormal_basement_membrane1.03310256
95MP0003942_abnormal_urinary_system1.03139358
96MP0001501_abnormal_sleep_pattern1.02662309
97MP0002277_abnormal_respiratory_mucosa1.02116152
98MP0003075_altered_response_to1.00569098
99MP0002229_neurodegeneration0.99939572
100MP0002752_abnormal_somatic_nervous0.98879446
101MP0003137_abnormal_impulse_conducting0.98341419
102MP0008789_abnormal_olfactory_epithelium0.98213408
103MP0002928_abnormal_bile_duct0.98092219
104MP0006276_abnormal_autonomic_nervous0.97076412
105MP0006072_abnormal_retinal_apoptosis0.96579614
106MP0009384_cardiac_valve_regurgitation0.96505322
107MP0005508_abnormal_skeleton_morphology0.96306342
108MP0003938_abnormal_ear_development0.94241015
109MP0001919_abnormal_reproductive_system0.93644664
110MP0000750_abnormal_muscle_regeneration0.90729211
111MP0002557_abnormal_social/conspecific_i0.90437758
112MP0002108_abnormal_muscle_morphology0.90151446
113MP0003878_abnormal_ear_physiology0.89320547
114MP0005377_hearing/vestibular/ear_phenot0.89320547
115MP0000749_muscle_degeneration0.89208023
116MP0003385_abnormal_body_wall0.89124866
117MP0005379_endocrine/exocrine_gland_phen0.89015346
118MP0002882_abnormal_neuron_morphology0.87981048
119MP0001764_abnormal_homeostasis0.87212494
120MP0001346_abnormal_lacrimal_gland0.86652173
121MP0005167_abnormal_blood-brain_barrier0.86395723
122MP0000049_abnormal_middle_ear0.84287526
123MP0000778_abnormal_nervous_system0.84119252
124MP0005195_abnormal_posterior_eye0.83356957
125MP0002067_abnormal_sensory_capabilities0.83126906
126MP0003115_abnormal_respiratory_system0.82071300
127MP0005595_abnormal_vascular_smooth0.81548567
128MP0003011_delayed_dark_adaptation0.81536614
129MP0004145_abnormal_muscle_electrophysio0.81132321
130MP0003718_maternal_effect0.80229863
131MP0002066_abnormal_motor_capabilities/c0.79024647
132MP0000733_abnormal_muscle_development0.78826961
133MP0004087_abnormal_muscle_fiber0.78443963
134MP0002938_white_spotting0.78092226
135MP0003172_abnormal_lysosome_physiology0.78072565
136MP0000383_abnormal_hair_follicle0.78013408
137MP0004147_increased_porphyrin_level0.77931224
138MP0001849_ear_inflammation0.76150466
139MP0002152_abnormal_brain_morphology0.75722410
140MP0002653_abnormal_ependyma_morphology0.75170565
141MP0003959_abnormal_lean_body0.75077887
142MP0001486_abnormal_startle_reflex0.75046380
143MP0001293_anophthalmia0.73747063
144MP0008770_decreased_survivor_rate0.72947929
145MP0002269_muscular_atrophy0.71520126
146MP0000537_abnormal_urethra_morphology0.71471465
147MP0004885_abnormal_endolymph0.67427245
148MP0008874_decreased_physiological_sensi0.65582081
149MP0004133_heterotaxia0.63977390
150MP0005084_abnormal_gallbladder_morpholo0.63476064
151MP0005423_abnormal_somatic_nervous0.62051353
152MP0002069_abnormal_eating/drinking_beha0.61339340
153MP0002837_dystrophic_cardiac_calcinosis0.61213112
154MP0001177_atelectasis0.60603118
155MP0003633_abnormal_nervous_system0.59883258
156MP0004084_abnormal_cardiac_muscle0.58998543
157MP0002282_abnormal_trachea_morphology0.58126630
158MP0010386_abnormal_urinary_bladder0.57813356

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.52030524
2Premature rupture of membranes (HP:0001788)4.35950019
3Type II lissencephaly (HP:0007260)3.84149618
4Abnormality of midbrain morphology (HP:0002418)3.71564217
5Molar tooth sign on MRI (HP:0002419)3.71564217
6Congenital stationary night blindness (HP:0007642)3.64293560
7Cerebral aneurysm (HP:0004944)3.47813464
8Pancreatic cysts (HP:0001737)3.46000250
9Myokymia (HP:0002411)3.36375565
10Pancreatic fibrosis (HP:0100732)3.32332646
11Shallow orbits (HP:0000586)3.32197116
12Distal upper limb amyotrophy (HP:0007149)3.19560577
13Upper limb amyotrophy (HP:0009129)3.19560577
14Inability to walk (HP:0002540)3.12839903
15True hermaphroditism (HP:0010459)3.12639617
16Nephronophthisis (HP:0000090)3.09986672
17Dilatation of the ascending aorta (HP:0005111)3.07430232
18Concave nail (HP:0001598)3.07198421
19Bladder diverticulum (HP:0000015)2.97170956
20Retinal dysplasia (HP:0007973)2.96499265
21Focal seizures (HP:0007359)2.96412920
22Abnormality of the lower motor neuron (HP:0002366)2.95819532
23Aortic aneurysm (HP:0004942)2.95208005
24Febrile seizures (HP:0002373)2.92413370
25Lissencephaly (HP:0001339)2.89407093
26Neonatal short-limb short stature (HP:0008921)2.89311136
27Visual hallucinations (HP:0002367)2.87620534
28Hyperventilation (HP:0002883)2.81134773
29Difficulty climbing stairs (HP:0003551)2.80028415
30Aortic dissection (HP:0002647)2.73611478
31Cystic liver disease (HP:0006706)2.73260862
32Hand muscle atrophy (HP:0009130)2.72362262
33Fragile skin (HP:0001030)2.72061485
34Achilles tendon contracture (HP:0001771)2.71251089
35Atrophic scars (HP:0001075)2.70997675
36Progressive inability to walk (HP:0002505)2.68918464
37Hypoventilation (HP:0002791)2.68470833
38Bowel diverticulosis (HP:0005222)2.68395392
39Oligodactyly (hands) (HP:0001180)2.66462794
40Abnormality of the labia minora (HP:0012880)2.65186981
41Lower limb amyotrophy (HP:0007210)2.64214347
42Limb dystonia (HP:0002451)2.60874936
43Mutism (HP:0002300)2.57102684
44Mildly elevated creatine phosphokinase (HP:0008180)2.56459087
45Hypercortisolism (HP:0001578)2.55768087
46Abnormality of the renal medulla (HP:0100957)2.55762021
47Abnormality of dentin (HP:0010299)2.55465814
48Broad metatarsal (HP:0001783)2.54479060
49Increased variability in muscle fiber diameter (HP:0003557)2.53694473
50Cervical subluxation (HP:0003308)2.52000983
51Peritonitis (HP:0002586)2.45174798
52Ankle contracture (HP:0006466)2.44263755
53Bronchomalacia (HP:0002780)2.44208284
54Acute necrotizing encephalopathy (HP:0006965)2.42921878
55Cerebellar dysplasia (HP:0007033)2.42509033
56Mitochondrial inheritance (HP:0001427)2.41079049
57Pachygyria (HP:0001302)2.38342874
58Hemiparesis (HP:0001269)2.38161429
59Genu recurvatum (HP:0002816)2.37892330
60Focal motor seizures (HP:0011153)2.37677617
61Chronic hepatic failure (HP:0100626)2.36924242
62Distal lower limb amyotrophy (HP:0008944)2.36740613
63Abnormality of the Achilles tendon (HP:0005109)2.36107787
64Limb-girdle muscle atrophy (HP:0003797)2.35554856
65Medial flaring of the eyebrow (HP:0010747)2.34043705
66Polyphagia (HP:0002591)2.33504693
67Supranuclear gaze palsy (HP:0000605)2.33336082
68Ankyloglossia (HP:0010296)2.32421208
69Sclerocornea (HP:0000647)2.31845675
70Spinal rigidity (HP:0003306)2.30302198
71Large for gestational age (HP:0001520)2.27826645
72Broad-based gait (HP:0002136)2.26907139
73Short nail (HP:0001799)2.26612684
74Aneurysm (HP:0002617)2.25965612
75Severe muscular hypotonia (HP:0006829)2.25824150
76Abnormality of the renal cortex (HP:0011035)2.25533353
77Atonic seizures (HP:0010819)2.25305161
78Wrist flexion contracture (HP:0001239)2.25161132
79Vertebral compression fractures (HP:0002953)2.24669651
80Overgrowth (HP:0001548)2.24525101
81Increased CSF lactate (HP:0002490)2.23282776
82Progressive microcephaly (HP:0000253)2.23214403
83Abnormality of skeletal muscle fiber size (HP:0012084)2.22085630
84Insomnia (HP:0100785)2.21608495
85Increased connective tissue (HP:0009025)2.20760299
86Patellar aplasia (HP:0006443)2.20561831
87Soft skin (HP:0000977)2.18805102
88Vascular tortuosity (HP:0004948)2.18693245
89Birth length less than 3rd percentile (HP:0003561)2.17508489
90Absent speech (HP:0001344)2.15697009
91Depression (HP:0000716)2.15209647
92Pointed chin (HP:0000307)2.15088050
933-Methylglutaconic aciduria (HP:0003535)2.14895693
94Agitation (HP:0000713)2.14611298
95Aplasia/Hypoplasia of the patella (HP:0006498)2.14076778
96Pendular nystagmus (HP:0012043)2.13550307
97Acute encephalopathy (HP:0006846)2.13080487
98Oligodactyly (HP:0012165)2.12967962
99Abnormal mitochondria in muscle tissue (HP:0008316)2.12889561
100Radial bowing (HP:0002986)2.12291806
101Gait imbalance (HP:0002141)2.11386197
102Wormian bones (HP:0002645)2.11080344
103Bile duct proliferation (HP:0001408)2.10970765
104Abnormal biliary tract physiology (HP:0012439)2.10970765
105Dysmetric saccades (HP:0000641)2.09242572
106Action tremor (HP:0002345)2.08979071
107Enlarged penis (HP:0000040)2.08808000
108Hyperextensible skin (HP:0000974)2.07476568
109Hepatocellular necrosis (HP:0001404)2.07257568
110Tubular atrophy (HP:0000092)2.06245194
111Arterial tortuosity (HP:0005116)2.05549308
112Abnormality of oral frenula (HP:0000190)2.04888794
113Type 1 muscle fiber predominance (HP:0003803)2.04283288
114Polydipsia (HP:0001959)2.04063699
115Abnormal drinking behavior (HP:0030082)2.04063699
116Optic nerve hypoplasia (HP:0000609)2.02826381
117Anterior segment dysgenesis (HP:0007700)2.01590129
118Epileptic encephalopathy (HP:0200134)1.99738173
119Congenital glaucoma (HP:0001087)1.99009954
120Long toe (HP:0010511)1.98399438
121Mitral valve prolapse (HP:0001634)1.98164766
122Protruding tongue (HP:0010808)1.97954747
123Attenuation of retinal blood vessels (HP:0007843)1.97672776
124Progressive macrocephaly (HP:0004481)1.97439196
125Biconcave vertebral bodies (HP:0004586)1.93845437
126Nephrogenic diabetes insipidus (HP:0009806)1.93766729
127Sleep apnea (HP:0010535)1.93283847
128Rapidly progressive (HP:0003678)1.92815276
129Abnormal rod and cone electroretinograms (HP:0008323)1.92493679
130Hypsarrhythmia (HP:0002521)1.91904549
131Annular pancreas (HP:0001734)1.91886417
132Status epilepticus (HP:0002133)1.91716405
133Abnormal eating behavior (HP:0100738)1.91486248
134Hepatic necrosis (HP:0002605)1.91419653
135Deviation of the hallux (HP:0010051)1.89670881
136Hemiplegia (HP:0002301)1.88454890
137Epileptiform EEG discharges (HP:0011182)1.88253221
138Widely spaced teeth (HP:0000687)1.87915121
139Striae distensae (HP:0001065)1.87498761
140Anencephaly (HP:0002323)1.87296320
141Impaired smooth pursuit (HP:0007772)1.86445129
142Congenital primary aphakia (HP:0007707)1.85838231
143Septo-optic dysplasia (HP:0100842)1.85721244
144Neoplasm of the heart (HP:0100544)1.85392171
145Shoulder girdle muscle weakness (HP:0003547)1.84924865
146Aplasia/hypoplasia of the uterus (HP:0008684)1.84867696
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84341024
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.84289122
149Abolished electroretinogram (ERG) (HP:0000550)1.84068340
150Increased hepatocellular lipid droplets (HP:0006565)1.84011785
151Scapular winging (HP:0003691)1.83569509
152Blue sclerae (HP:0000592)1.83338818
153Hallux valgus (HP:0001822)1.82670017
154EEG with generalized epileptiform discharges (HP:0011198)1.82524225
155Turricephaly (HP:0000262)1.80983455
156Torticollis (HP:0000473)1.79591478
157Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78413763
158Occipital encephalocele (HP:0002085)1.78276750
159Optic disc pallor (HP:0000543)1.78165311
160Abnormality of the pons (HP:0007361)1.77539947
161Pelvic girdle muscle weakness (HP:0003749)1.77358939
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77116992
163Abnormality of alanine metabolism (HP:0010916)1.77116992
164Hyperalaninemia (HP:0003348)1.77116992
165Generalized tonic-clonic seizures (HP:0002069)1.76369098
166Synostosis involving the elbow (HP:0003938)1.75907234
167Humeroradial synostosis (HP:0003041)1.75907234
168Bowed forearm bones (HP:0003956)1.75845610
169Bowing of the arm (HP:0006488)1.75845610
170Lipid accumulation in hepatocytes (HP:0006561)1.75509704
171Intellectual disability, severe (HP:0010864)1.75240493
172Spastic tetraplegia (HP:0002510)1.75128218
173Rib fusion (HP:0000902)1.74965662
174Hyperacusis (HP:0010780)1.74750993
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74201029
176Abnormality of the hip-girdle musculature (HP:0001445)1.74083203
177Abnormality of the musculature of the pelvis (HP:0001469)1.74083203
178Bradycardia (HP:0001662)1.73608886
179Progressive cerebellar ataxia (HP:0002073)1.73458178
180Ankle clonus (HP:0011448)1.73422106
181Hypoplasia of the pons (HP:0012110)1.73276716
182Buphthalmos (HP:0000557)1.72884698
183Clumsiness (HP:0002312)1.72873733
184Abnormal respiratory motile cilium morphology (HP:0005938)1.72713823
185Abnormal respiratory epithelium morphology (HP:0012253)1.72713823
186Congenital hip dislocation (HP:0001374)1.71054001
187Spinal cord compression (HP:0002176)1.69844674
188Abnormality of the acetabulum (HP:0003170)1.69721143
189Osteopenia (HP:0000938)1.68438258
190Amblyopia (HP:0000646)1.66248330
191Mitral regurgitation (HP:0001653)1.64053752
192Long palpebral fissure (HP:0000637)1.63939142
193Myotonia (HP:0002486)1.63466714
194Impaired pain sensation (HP:0007328)1.61792944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.68622843
2NTRK33.34858063
3TRIB32.95972585
4ADRBK22.94928094
5LATS22.65257025
6MAP4K22.60601792
7PDGFRA2.54242319
8WNK32.53558566
9WNK42.40465936
10PINK12.39552008
11DDR22.35969143
12PKN22.31910870
13BMPR1B2.29056916
14MINK12.24723065
15ZAK2.18772207
16FRK2.18041941
17KSR22.16614198
18EPHA42.13860069
19MAPK132.13096962
20PAK62.10047807
21CASK2.03323496
22NTRK12.00851157
23BCKDK1.91864413
24DAPK21.89814234
25SCYL21.89541336
26NUAK11.82965033
27CAMKK11.74834071
28TTN1.70796938
29PRKD31.69871956
30ERN11.67215072
31FER1.65211292
32KSR11.64077819
33ARAF1.63176797
34DYRK21.58965480
35TYRO31.55975142
36TAOK31.55676859
37PTK21.55528973
38GRK11.44189760
39TLK11.42176927
40TNIK1.41176670
41RET1.37386789
42MAP3K121.35956317
43PAK31.32242059
44PNCK1.30233767
45PTK2B1.28278017
46TAOK11.25077913
47RIPK11.23955982
48MAP3K41.23127245
49MAP3K101.20657250
50SIK21.19750211
51DAPK11.19419470
52CAMK1D1.19203218
53STK381.17558535
54EEF2K1.16371958
55BMX1.16331228
56TGFBR11.15155353
57MAP3K131.12949833
58TAOK21.12286807
59CSNK1G21.11189148
60MUSK1.10609885
61MAPKAPK51.10117157
62MAP2K11.09596935
63CSNK1G31.09059897
64TESK11.07824447
65LMTK21.03312342
66NME11.02248798
67MAP2K41.01926867
68PKN11.01629019
69MOS1.01069718
70MAPK151.00547502
71CDK51.00467091
72LIMK11.00339002
73VRK10.98618841
74PLK20.98313569
75ALK0.97597505
76DAPK30.97584425
77CDK180.96823713
78CDK150.96211560
79CDK140.96209313
80NTRK20.94816134
81CSNK1G10.93699584
82MARK10.93328311
83NEK10.92620089
84MAP2K60.91607878
85MAP3K20.90978541
86CAMKK20.89502044
87ACVR1B0.89112597
88PAK20.88831407
89CDC42BPA0.87033606
90CDK11A0.86338306
91OXSR10.85838887
92EPHA20.85292986
93MAP2K70.83812726
94DMPK0.83301135
95MAPKAPK30.82452886
96MAP3K10.80670829
97CSNK1A1L0.80594911
98PRKCH0.76953963
99PTK60.76661098
100UHMK10.74102736
101MAP3K50.72359626
102CAMK2A0.72237041
103ICK0.71614291
104RPS6KA20.70586381
105TNK20.70033568
106FGFR10.69540855
107IKBKB0.68018574
108MAP3K110.67455444
109RAF10.66075357
110VRK20.65952512
111STK110.65739711
112MATK0.65697408
113MAP3K70.65326864
114PDGFRB0.64960840
115ADRBK10.64868782
116CHUK0.63663723
117CAMK2B0.63100093
118PRKCI0.61859458
119PRKCG0.60947222
120ROCK10.60864998
121TRPM70.60799569
122CCNB10.60567605
123CAMK1G0.58997729
124BRSK10.58734086
125CAMK10.58024404
126CAMK40.57903268
127MARK20.57737419
128GRK50.57243178
129PIM20.55912991
130PRKCZ0.55840177
131GRK70.55551612
132LRRK20.55410597
133RPS6KA50.55348023
134PRKCE0.54594418
135PHKG20.53827501
136PHKG10.53827501
137WEE10.53708663
138PAK40.52907456
139SGK4940.50866506
140SGK2230.50866506
141PRKAA10.49818036
142PRKACA0.49183440
143TAF10.49100391
144FGFR40.48963819
145PRPF4B0.48939599
146DYRK1B0.47204939
147TXK0.46206500
148TRIM280.44704371
149INSRR0.44095753
150PRKCQ0.43970003
151CDK90.43715507
152PRKD20.43705495
153ROCK20.42739881
154ERBB30.42053861
155MAPK120.41613166
156CDK190.41187400
157MKNK20.40787980
158BRSK20.39727280
159PRKD10.39268091
160TESK20.38940452
161STK390.38008874
162MTOR0.37800033
163EPHB20.37509603
164SRC0.37435473
165CSNK1A10.37316130
166PASK0.37242088
167FGR0.33840702

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.37259050
2Phototransduction_Homo sapiens_hsa047443.12268807
3Oxidative phosphorylation_Homo sapiens_hsa001903.08479717
4Synaptic vesicle cycle_Homo sapiens_hsa047212.69439321
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38160322
6Parkinsons disease_Homo sapiens_hsa050122.27530287
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22131347
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16052056
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06656944
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05140297
11Butanoate metabolism_Homo sapiens_hsa006501.99584266
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92996844
13Linoleic acid metabolism_Homo sapiens_hsa005911.91785348
14Long-term potentiation_Homo sapiens_hsa047201.91406969
15Circadian entrainment_Homo sapiens_hsa047131.88445336
16Nicotine addiction_Homo sapiens_hsa050331.87721315
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86802265
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82823511
19Olfactory transduction_Homo sapiens_hsa047401.79435404
20Cardiac muscle contraction_Homo sapiens_hsa042601.75712238
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71862378
22Amphetamine addiction_Homo sapiens_hsa050311.71460450
23Dopaminergic synapse_Homo sapiens_hsa047281.64173970
24Nitrogen metabolism_Homo sapiens_hsa009101.62928417
25Glioma_Homo sapiens_hsa052141.61016697
26Insulin secretion_Homo sapiens_hsa049111.60639942
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60305721
28RNA polymerase_Homo sapiens_hsa030201.57350856
29Ether lipid metabolism_Homo sapiens_hsa005651.56221728
30GABAergic synapse_Homo sapiens_hsa047271.54337682
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53439079
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52551637
33Huntingtons disease_Homo sapiens_hsa050161.52248451
34Glutamatergic synapse_Homo sapiens_hsa047241.52038564
35Gastric acid secretion_Homo sapiens_hsa049711.50958050
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50090782
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.48034085
38Alzheimers disease_Homo sapiens_hsa050101.47244131
39Oxytocin signaling pathway_Homo sapiens_hsa049211.47076901
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46069647
41Salivary secretion_Homo sapiens_hsa049701.45444711
42Sulfur relay system_Homo sapiens_hsa041221.44142466
43Gap junction_Homo sapiens_hsa045401.42529855
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41331097
45GnRH signaling pathway_Homo sapiens_hsa049121.41328289
46Cholinergic synapse_Homo sapiens_hsa047251.39969350
47Basal transcription factors_Homo sapiens_hsa030221.37292355
48Dilated cardiomyopathy_Homo sapiens_hsa054141.36067649
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35574990
50Bladder cancer_Homo sapiens_hsa052191.34180548
51Cocaine addiction_Homo sapiens_hsa050301.33791353
52Morphine addiction_Homo sapiens_hsa050321.32915721
53Estrogen signaling pathway_Homo sapiens_hsa049151.31188403
54Homologous recombination_Homo sapiens_hsa034401.30215612
55Protein export_Homo sapiens_hsa030601.26803014
56Focal adhesion_Homo sapiens_hsa045101.26139964
57Proteoglycans in cancer_Homo sapiens_hsa052051.22243129
58Vibrio cholerae infection_Homo sapiens_hsa051101.21176399
59VEGF signaling pathway_Homo sapiens_hsa043701.20686864
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19619570
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18207163
62ErbB signaling pathway_Homo sapiens_hsa040121.15774753
63Long-term depression_Homo sapiens_hsa047301.13933378
64Ovarian steroidogenesis_Homo sapiens_hsa049131.13634484
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13052629
66Neurotrophin signaling pathway_Homo sapiens_hsa047221.12647109
67Tryptophan metabolism_Homo sapiens_hsa003801.11457499
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09622753
69Melanogenesis_Homo sapiens_hsa049161.08969252
70Selenocompound metabolism_Homo sapiens_hsa004501.08770462
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07199896
72Calcium signaling pathway_Homo sapiens_hsa040201.05957522
73mTOR signaling pathway_Homo sapiens_hsa041501.04694608
74Axon guidance_Homo sapiens_hsa043601.03427150
75Fanconi anemia pathway_Homo sapiens_hsa034601.02529603
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02043200
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01531777
78Type II diabetes mellitus_Homo sapiens_hsa049300.97896158
79ECM-receptor interaction_Homo sapiens_hsa045120.97404861
80Ribosome_Homo sapiens_hsa030100.96639374
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95457886
82Thyroid hormone synthesis_Homo sapiens_hsa049180.93767883
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93325764
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.92475040
85Renin secretion_Homo sapiens_hsa049240.92383516
86Chronic myeloid leukemia_Homo sapiens_hsa052200.92223828
87Rap1 signaling pathway_Homo sapiens_hsa040150.92189815
88Taste transduction_Homo sapiens_hsa047420.92134419
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.92047228
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89585057
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88611297
92cAMP signaling pathway_Homo sapiens_hsa040240.87315654
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86363817
94Endocytosis_Homo sapiens_hsa041440.85402258
95Hippo signaling pathway_Homo sapiens_hsa043900.84926496
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.84780226
97ABC transporters_Homo sapiens_hsa020100.81849514
98Serotonergic synapse_Homo sapiens_hsa047260.81747153
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81228147
100Shigellosis_Homo sapiens_hsa051310.81183118
101Adherens junction_Homo sapiens_hsa045200.80595983
102Insulin signaling pathway_Homo sapiens_hsa049100.80541343
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79882265
104Endometrial cancer_Homo sapiens_hsa052130.79820113
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.79418201
106RNA degradation_Homo sapiens_hsa030180.79023462
107Amoebiasis_Homo sapiens_hsa051460.78373768
108Caffeine metabolism_Homo sapiens_hsa002320.78203973
109Collecting duct acid secretion_Homo sapiens_hsa049660.76979765
110HIF-1 signaling pathway_Homo sapiens_hsa040660.76172859
111MAPK signaling pathway_Homo sapiens_hsa040100.76055874
112Non-small cell lung cancer_Homo sapiens_hsa052230.73624383
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72996029
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72006575
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71877597
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71377159
117Choline metabolism in cancer_Homo sapiens_hsa052310.67415424
118Glucagon signaling pathway_Homo sapiens_hsa049220.66961753
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66863703
120Oocyte meiosis_Homo sapiens_hsa041140.65366317
121Regulation of autophagy_Homo sapiens_hsa041400.64497179
122Prion diseases_Homo sapiens_hsa050200.63809523
123Peroxisome_Homo sapiens_hsa041460.62510126
124Circadian rhythm_Homo sapiens_hsa047100.62370795
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61298332
126Vitamin B6 metabolism_Homo sapiens_hsa007500.60937209
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60569636
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60207898
129Tight junction_Homo sapiens_hsa045300.58833859
130Colorectal cancer_Homo sapiens_hsa052100.58631610
131Steroid biosynthesis_Homo sapiens_hsa001000.58490040
132Melanoma_Homo sapiens_hsa052180.58481449
133Wnt signaling pathway_Homo sapiens_hsa043100.56977328
134Prolactin signaling pathway_Homo sapiens_hsa049170.56897342
135beta-Alanine metabolism_Homo sapiens_hsa004100.56787492
136Salmonella infection_Homo sapiens_hsa051320.55360102
137Ras signaling pathway_Homo sapiens_hsa040140.55331117
138Thyroid cancer_Homo sapiens_hsa052160.54891573
139Platelet activation_Homo sapiens_hsa046110.54619285
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54049414
141MicroRNAs in cancer_Homo sapiens_hsa052060.51703303
142Basal cell carcinoma_Homo sapiens_hsa052170.51684791
143Dorso-ventral axis formation_Homo sapiens_hsa043200.51636970
144Pancreatic secretion_Homo sapiens_hsa049720.51056525
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.50390756
146Purine metabolism_Homo sapiens_hsa002300.49482625
147Metabolic pathways_Homo sapiens_hsa011000.48205971
148Rheumatoid arthritis_Homo sapiens_hsa053230.48130140
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47090237
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.46291420
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.44118447
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43509497
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42825829
154Primary immunodeficiency_Homo sapiens_hsa053400.40153653
155Glycerolipid metabolism_Homo sapiens_hsa005610.39561311
156Propanoate metabolism_Homo sapiens_hsa006400.37780758
157Arachidonic acid metabolism_Homo sapiens_hsa005900.36386600
158Lysosome_Homo sapiens_hsa041420.35575472
159Hedgehog signaling pathway_Homo sapiens_hsa043400.34677109
160Glycosaminoglycan degradation_Homo sapiens_hsa005310.30994866
161Alcoholism_Homo sapiens_hsa050340.29848139
162Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29501910
163Mineral absorption_Homo sapiens_hsa049780.26283626
164Glycerophospholipid metabolism_Homo sapiens_hsa005640.23854576
165Arginine and proline metabolism_Homo sapiens_hsa003300.22774144

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