KLHL28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inositol phosphate catabolic process (GO:0071545)5.67466868
2inositol phosphate dephosphorylation (GO:0046855)5.65952491
3phosphorylated carbohydrate dephosphorylation (GO:0046838)5.65952491
4negative regulation of dendrite morphogenesis (GO:0050774)5.64563149
5ER overload response (GO:0006983)5.51003088
6presynaptic membrane assembly (GO:0097105)5.20062234
7neural tube formation (GO:0001841)4.65738983
8snRNA transcription (GO:0009301)4.55384667
9limb bud formation (GO:0060174)4.36973965
10presynaptic membrane organization (GO:0097090)4.28780290
11pyrimidine nucleobase catabolic process (GO:0006208)4.12888504
12prostate gland growth (GO:0060736)3.83750753
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.78848885
14protein localization to cilium (GO:0061512)3.55741679
15nucleobase catabolic process (GO:0046113)3.51951599
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.45893600
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.45893600
18regulation of translation, ncRNA-mediated (GO:0045974)3.45893600
19negative regulation of neurotransmitter secretion (GO:0046929)3.41911123
20negative regulation of dendrite development (GO:2000171)3.40287243
21cilium morphogenesis (GO:0060271)3.38124316
22polyol catabolic process (GO:0046174)3.37882856
23phosphatidylinositol dephosphorylation (GO:0046856)3.33614841
24prenylation (GO:0097354)3.33303555
25protein prenylation (GO:0018342)3.33303555
26neutrophil activation involved in immune response (GO:0002283)3.32263589
27negative regulation of neurotransmitter transport (GO:0051589)3.29209645
28eye photoreceptor cell differentiation (GO:0001754)3.21491042
29photoreceptor cell differentiation (GO:0046530)3.21491042
30cerebellar Purkinje cell differentiation (GO:0021702)3.20444070
31DNA double-strand break processing (GO:0000729)3.18578026
32regulation of cilium movement (GO:0003352)3.17306789
33epithelial cilium movement (GO:0003351)3.11882550
34regulation of hexokinase activity (GO:1903299)3.10606314
35regulation of glucokinase activity (GO:0033131)3.10606314
36glycosphingolipid biosynthetic process (GO:0006688)3.10294620
37neuron cell-cell adhesion (GO:0007158)3.09918243
38kidney morphogenesis (GO:0060993)3.07738114
39regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.06780166
40regulation of protein polyubiquitination (GO:1902914)3.05899890
41retinal ganglion cell axon guidance (GO:0031290)3.05437745
42cilium organization (GO:0044782)3.05057336
43dendritic spine morphogenesis (GO:0060997)3.02400934
44olfactory bulb development (GO:0021772)3.02260325
45signal peptide processing (GO:0006465)3.00883350
46cilium assembly (GO:0042384)3.00217653
47regulation of pigment cell differentiation (GO:0050932)2.96590423
48intraciliary transport (GO:0042073)2.96081722
49regulation of RIG-I signaling pathway (GO:0039535)2.95753148
50L-fucose catabolic process (GO:0042355)2.94564923
51fucose catabolic process (GO:0019317)2.94564923
52L-fucose metabolic process (GO:0042354)2.94564923
53phospholipid dephosphorylation (GO:0046839)2.94229657
54somite development (GO:0061053)2.91378927
55maternal behavior (GO:0042711)2.89866726
56cornea development in camera-type eye (GO:0061303)2.89135259
57neuron fate determination (GO:0048664)2.88464762
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88042432
59urinary tract smooth muscle contraction (GO:0014848)2.87044364
60axoneme assembly (GO:0035082)2.86979807
61establishment of protein localization to Golgi (GO:0072600)2.86279906
62parental behavior (GO:0060746)2.86220088
63photoreceptor cell maintenance (GO:0045494)2.85786671
64intracellular pH reduction (GO:0051452)2.84395856
65positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.84284220
66mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.84284220
67response to pheromone (GO:0019236)2.84179652
68regulation of feeding behavior (GO:0060259)2.83431779
69deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.83396355
70negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.81281315
71regulation of telomere maintenance (GO:0032204)2.81230468
72negative regulation of phagocytosis (GO:0050765)2.78914069
73negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.77199818
74retinal cone cell development (GO:0046549)2.76603657
75cellular response to prostaglandin stimulus (GO:0071379)2.76291146
76preassembly of GPI anchor in ER membrane (GO:0016254)2.75995473
77water-soluble vitamin biosynthetic process (GO:0042364)2.75590036
78synaptic vesicle exocytosis (GO:0016079)2.75407667
79platelet dense granule organization (GO:0060155)2.75153223
80multicellular organismal reproductive behavior (GO:0033057)2.74525817
81protein targeting to Golgi (GO:0000042)2.74389999
82gamma-aminobutyric acid transport (GO:0015812)2.74351052
83negative regulation of membrane potential (GO:0045837)2.73505562
84embryonic epithelial tube formation (GO:0001838)2.72198082
85cullin deneddylation (GO:0010388)2.70696083
86positive regulation of oligodendrocyte differentiation (GO:0048714)2.70506231
87cellular response to gamma radiation (GO:0071480)2.68693097
88glial cell proliferation (GO:0014009)2.67364101
89central nervous system neuron axonogenesis (GO:0021955)2.66477334
90keratinocyte development (GO:0003334)2.65809603
91dentate gyrus development (GO:0021542)2.65324087
92regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.65295826
93phagosome maturation (GO:0090382)2.61357677
94regulation of collateral sprouting (GO:0048670)2.61019536
95establishment of melanosome localization (GO:0032401)2.60555697
96long-chain fatty acid biosynthetic process (GO:0042759)2.59656913
97calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59193017
98cilium movement (GO:0003341)2.59070163
99positive regulation of microtubule polymerization (GO:0031116)2.58255564
100lactate metabolic process (GO:0006089)2.58149900
101behavioral response to ethanol (GO:0048149)2.57713276
102long-term synaptic potentiation (GO:0060291)2.56539300
103establishment of pigment granule localization (GO:0051905)2.55459330
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.54687121
105axonal fasciculation (GO:0007413)2.54669442
106regulation of timing of cell differentiation (GO:0048505)2.52597591
107T-helper cell differentiation (GO:0042093)2.51869078
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.51869078
109negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50894918
110activated T cell proliferation (GO:0050798)2.50822435
111histone H2A acetylation (GO:0043968)2.50262419
112epithelial tube formation (GO:0072175)2.49612156
113neutrophil activation (GO:0042119)2.49604538
114protein localization to Golgi apparatus (GO:0034067)2.49207834
115retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48858888
116positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.48347154
117serotonin metabolic process (GO:0042428)2.48110490
118central nervous system projection neuron axonogenesis (GO:0021952)2.48058386
119negative regulation of exocytosis (GO:0045920)2.47808061
120regulation of metalloenzyme activity (GO:0048552)2.46958057
121photoreceptor cell development (GO:0042461)2.46802111
122glycerophospholipid catabolic process (GO:0046475)2.46770634
123positive regulation of amino acid transport (GO:0051957)2.46237496
124protein K11-linked deubiquitination (GO:0035871)2.46154374
125G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46007788
126negative regulation of axon guidance (GO:1902668)2.45348362
127melanosome transport (GO:0032402)2.45133545
128positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.45034688
129negative regulation of neurological system process (GO:0031645)2.44786185
130mannosylation (GO:0097502)2.44606060
131appendage development (GO:0048736)2.44394007
132limb development (GO:0060173)2.44394007
133cellular component assembly involved in morphogenesis (GO:0010927)2.43826597
134somite rostral/caudal axis specification (GO:0032525)2.43729013
135pH reduction (GO:0045851)2.43634336
136dendrite development (GO:0016358)2.43615633
137GPI anchor metabolic process (GO:0006505)2.43480208
138inner ear receptor stereocilium organization (GO:0060122)2.43345541
139autophagic vacuole fusion (GO:0000046)2.41724253
140negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.41700159
141DNA integration (GO:0015074)2.41554142
142transferrin transport (GO:0033572)2.41336325
143pigment granule transport (GO:0051904)2.40528883
144C-terminal protein amino acid modification (GO:0018410)2.40242706
145negative regulation of protein oligomerization (GO:0032460)2.39999769
146resolution of meiotic recombination intermediates (GO:0000712)2.39610414
147branched-chain amino acid catabolic process (GO:0009083)2.39344695
148cellular ketone body metabolic process (GO:0046950)2.39309920
149regulation of development, heterochronic (GO:0040034)2.39258382
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.38995117
151negative regulation of T-helper cell differentiation (GO:0045623)2.38995117
152protein deneddylation (GO:0000338)2.38874086
153positive regulation of alpha-beta T cell proliferation (GO:0046641)2.38161986
154protein neddylation (GO:0045116)2.37539212
155replication fork processing (GO:0031297)2.37538625
156regulation of heat generation (GO:0031650)2.36920188
157synapse assembly (GO:0007416)2.36816038
158regulation of alpha-beta T cell proliferation (GO:0046640)2.36313882
159synaptic vesicle docking involved in exocytosis (GO:0016081)2.36310737
160C-terminal protein lipidation (GO:0006501)2.35758717
161hindbrain development (GO:0030902)2.35089095
162positive regulation of mitochondrial fission (GO:0090141)2.33792263
163megakaryocyte development (GO:0035855)2.33059321
164cellular response to interferon-beta (GO:0035458)2.31918685
165granulocyte activation (GO:0036230)2.31792994
166postsynaptic membrane organization (GO:0001941)2.31597336
167nerve growth factor signaling pathway (GO:0038180)2.31303493
168negative regulation of B cell mediated immunity (GO:0002713)2.31248313
169negative regulation of immunoglobulin mediated immune response (GO:0002890)2.31248313
170nonmotile primary cilium assembly (GO:0035058)2.28794794
171positive regulation of developmental pigmentation (GO:0048087)2.28483826
172parturition (GO:0007567)2.28195035
173viral protein processing (GO:0019082)2.26396474
174negative regulation of mast cell activation (GO:0033004)2.26218761
175startle response (GO:0001964)2.25524860
176regulation of oxidative phosphorylation (GO:0002082)2.23576884
177CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.22519674
178membrane assembly (GO:0071709)2.22413141
179regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.21986672
180myelin maintenance (GO:0043217)2.21597344
181anterograde synaptic vesicle transport (GO:0048490)2.20538934
182cerebral cortex radially oriented cell migration (GO:0021799)2.19177899
183cellular response to interleukin-15 (GO:0071350)2.18538906
184positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.16879253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91007540
2GBX2_23144817_ChIP-Seq_PC3_Human3.67198228
3EZH2_22144423_ChIP-Seq_EOC_Human3.47770242
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.41522551
5ZNF274_21170338_ChIP-Seq_K562_Hela3.34782228
6TAF15_26573619_Chip-Seq_HEK293_Human3.29331219
7* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86440428
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78049480
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.75747939
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68801608
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57294868
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40455929
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.35504727
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.12014581
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.09140580
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00249457
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91986846
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90587276
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.86237927
20P300_19829295_ChIP-Seq_ESCs_Human1.84922373
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82556960
22* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78435784
23NANOG_18555785_Chip-Seq_ESCs_Mouse1.71190365
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70853048
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65088772
26FUS_26573619_Chip-Seq_HEK293_Human1.64377017
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.64003151
28ER_23166858_ChIP-Seq_MCF-7_Human1.61116899
29SMAD4_21799915_ChIP-Seq_A2780_Human1.60580963
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56985709
31P53_22387025_ChIP-Seq_ESCs_Mouse1.56858053
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.56109576
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54682838
34CMYC_18555785_Chip-Seq_ESCs_Mouse1.53715517
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.53588392
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53162757
37BCAT_22108803_ChIP-Seq_LS180_Human1.52954722
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.52398519
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52386670
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52364533
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47555650
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47138545
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.46360832
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46050256
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45699589
46ELK1_19687146_ChIP-ChIP_HELA_Human1.45603176
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45423977
48VDR_22108803_ChIP-Seq_LS180_Human1.45165673
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44992351
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42989631
51TCF4_23295773_ChIP-Seq_U87_Human1.42611428
52IGF1R_20145208_ChIP-Seq_DFB_Human1.40309615
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39582212
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39316619
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38822912
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.34607311
57AR_25329375_ChIP-Seq_VCAP_Human1.32735275
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32704329
59P300_18555785_Chip-Seq_ESCs_Mouse1.32441727
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31084189
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.30963329
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29295272
63KDM2B_26808549_Chip-Seq_REH_Human1.27437017
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27296112
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.27134587
66EWS_26573619_Chip-Seq_HEK293_Human1.27085261
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.26285537
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25904003
69RNF2_27304074_Chip-Seq_NSC_Mouse1.25371638
70SOX2_18555785_Chip-Seq_ESCs_Mouse1.25289154
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.25141081
72TCF4_22108803_ChIP-Seq_LS180_Human1.24997697
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24308584
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.22915831
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.22902768
76RUNX2_22187159_ChIP-Seq_PCA_Human1.22897285
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21375803
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.21087408
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21046246
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21046246
81NANOG_19829295_ChIP-Seq_ESCs_Human1.20718745
82SOX2_19829295_ChIP-Seq_ESCs_Human1.20718745
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19314012
84STAT3_23295773_ChIP-Seq_U87_Human1.19059936
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18888634
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18113833
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.17955921
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16836983
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16572482
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16088261
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.14534498
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13374381
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10883134
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10540640
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10325058
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09266483
97TP53_22573176_ChIP-Seq_HFKS_Human1.07766212
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07574001
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06903310
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06839673
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.06677819
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06539559
103PU1_27457419_Chip-Seq_LIVER_Mouse1.06298698
104SMAD1_18555785_Chip-Seq_ESCs_Mouse1.05566513
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05377341
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.05179516
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.04866827
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.04473073
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.04230127
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03139396
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03098810
112CDX2_22108803_ChIP-Seq_LS180_Human1.03008876
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01468143
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.00842903
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00496397
116KLF4_18555785_Chip-Seq_ESCs_Mouse0.99978727
117AHR_22903824_ChIP-Seq_MCF-7_Human0.99866207
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99816421
119JUN_21703547_ChIP-Seq_K562_Human0.98788176
120ZFX_18555785_Chip-Seq_ESCs_Mouse0.98712863
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97603185
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97009626
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96056257
124CBP_20019798_ChIP-Seq_JUKART_Human0.96056257
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.95503978
126RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95047062
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94486157
128OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93397537
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.93089329
130REST_21632747_ChIP-Seq_MESCs_Mouse0.92509934
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92480280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.23300262
2MP0005171_absent_coat_pigmentation4.10540144
3MP0003183_abnormal_peptide_metabolism2.94198708
4MP0003787_abnormal_imprinting2.91795940
5MP0009697_abnormal_copulation2.81313448
6MP0000569_abnormal_digit_pigmentation2.79881179
7MP0003880_abnormal_central_pattern2.75477947
8MP0001984_abnormal_olfaction2.48690434
9MP0010234_abnormal_vibrissa_follicle2.38395919
10MP0006276_abnormal_autonomic_nervous2.26712045
11MP0006072_abnormal_retinal_apoptosis2.24627063
12MP0004270_analgesia2.18429257
13MP0008789_abnormal_olfactory_epithelium2.15386741
14MP0003122_maternal_imprinting2.11558742
15MP0004859_abnormal_synaptic_plasticity2.08119170
16MP0005409_darkened_coat_color2.05083476
17MP0005645_abnormal_hypothalamus_physiol1.99407683
18MP0005253_abnormal_eye_physiology1.98461375
19MP0005671_abnormal_response_to1.93364839
20MP0005551_abnormal_eye_electrophysiolog1.90810844
21MP0002734_abnormal_mechanical_nocicepti1.85574976
22MP0005499_abnormal_olfactory_system1.85444863
23MP0005394_taste/olfaction_phenotype1.85444863
24MP0002751_abnormal_autonomic_nervous1.78081107
25MP0003890_abnormal_embryonic-extraembry1.76144518
26MP0003011_delayed_dark_adaptation1.73040252
27MP0000015_abnormal_ear_pigmentation1.72515709
28MP0002160_abnormal_reproductive_system1.72176444
29MP0001905_abnormal_dopamine_level1.71211044
30MP0005646_abnormal_pituitary_gland1.70820048
31MP0000516_abnormal_urinary_system1.69373207
32MP0005367_renal/urinary_system_phenotyp1.69373207
33MP0008057_abnormal_DNA_replication1.67338041
34MP0002736_abnormal_nociception_after1.66885936
35MP0003195_calcinosis1.65692601
36MP0002938_white_spotting1.65152048
37MP0006292_abnormal_olfactory_placode1.64583363
38MP0004742_abnormal_vestibular_system1.62814694
39MP0001968_abnormal_touch/_nociception1.61891864
40MP0010386_abnormal_urinary_bladder1.59464193
41MP0003635_abnormal_synaptic_transmissio1.57523615
42MP0009046_muscle_twitch1.57112340
43MP0000778_abnormal_nervous_system1.55885411
44MP0002876_abnormal_thyroid_physiology1.51778866
45MP0002822_catalepsy1.50158093
46MP0002064_seizures1.49546407
47MP0001529_abnormal_vocalization1.49487021
48MP0008058_abnormal_DNA_repair1.45884620
49MP0000631_abnormal_neuroendocrine_gland1.44994772
50MP0000681_abnormal_thyroid_gland1.44902020
51MP0004133_heterotaxia1.43623962
52MP0009780_abnormal_chondrocyte_physiolo1.43385049
53MP0008877_abnormal_DNA_methylation1.42586489
54MP0002234_abnormal_pharynx_morphology1.41866679
55MP0002837_dystrophic_cardiac_calcinosis1.39417182
56MP0009745_abnormal_behavioral_response1.37907178
57MP0002272_abnormal_nervous_system1.37469144
58MP0002572_abnormal_emotion/affect_behav1.36686995
59MP0002735_abnormal_chemical_nociception1.35379008
60MP0002928_abnormal_bile_duct1.35245423
61MP0004924_abnormal_behavior1.33426565
62MP0005386_behavior/neurological_phenoty1.33426565
63MP0005248_abnormal_Harderian_gland1.33021660
64MP0002063_abnormal_learning/memory/cond1.32208681
65MP0000920_abnormal_myelination1.30459616
66MP0005379_endocrine/exocrine_gland_phen1.29914493
67MP0005387_immune_system_phenotype1.29665237
68MP0001790_abnormal_immune_system1.29665237
69MP0001800_abnormal_humoral_immune1.29057982
70MP0002638_abnormal_pupillary_reflex1.28758226
71MP0005187_abnormal_penis_morphology1.27123424
72MP0000383_abnormal_hair_follicle1.24916798
73MP0002148_abnormal_hypersensitivity_rea1.24380231
74MP0008995_early_reproductive_senescence1.24165066
75MP0005000_abnormal_immune_tolerance1.23800843
76MP0001835_abnormal_antigen_presentation1.23042989
77MP0001545_abnormal_hematopoietic_system1.21989358
78MP0005397_hematopoietic_system_phenotyp1.21989358
79MP0000647_abnormal_sebaceous_gland1.20431371
80MP0010678_abnormal_skin_adnexa1.20057140
81MP0002067_abnormal_sensory_capabilities1.19647040
82MP0003136_yellow_coat_color1.18344664
83MP0004215_abnormal_myocardial_fiber1.14399054
84MP0001486_abnormal_startle_reflex1.14276016
85MP0002277_abnormal_respiratory_mucosa1.13728930
86MP0002233_abnormal_nose_morphology1.13638383
87MP0003763_abnormal_thymus_physiology1.12434290
88MP0002452_abnormal_antigen_presenting1.12076149
89MP0003718_maternal_effect1.11939334
90MP0005084_abnormal_gallbladder_morpholo1.11371472
91MP0001986_abnormal_taste_sensitivity1.10118917
92MP0002933_joint_inflammation1.09420680
93MP0002723_abnormal_immune_serum1.09323963
94MP0002419_abnormal_innate_immunity1.08196172
95MP0002420_abnormal_adaptive_immunity1.07967699
96MP0009785_altered_susceptibility_to1.07482499
97MP0001819_abnormal_immune_cell1.06719014
98MP0003119_abnormal_digestive_system1.06674489
99MP0000685_abnormal_immune_system1.03605168
100MP0004885_abnormal_endolymph1.03432393
101MP0004142_abnormal_muscle_tone1.03054456
102MP0001485_abnormal_pinna_reflex1.02647764
103MP0002229_neurodegeneration0.99962468
104MP0001188_hyperpigmentation0.99825787
105MP0001293_anophthalmia0.98821808
106MP0002557_abnormal_social/conspecific_i0.95393150
107MP0001970_abnormal_pain_threshold0.95252055
108MP0002752_abnormal_somatic_nervous0.95036766
109MP0005389_reproductive_system_phenotype0.94774405
110MP0002090_abnormal_vision0.94201904
111MP0003724_increased_susceptibility_to0.94176666
112MP0003634_abnormal_glial_cell0.93944773
113MP0005075_abnormal_melanosome_morpholog0.92828502
114MP0003121_genomic_imprinting0.92297809
115MP0005310_abnormal_salivary_gland0.91948661
116MP0000427_abnormal_hair_cycle0.91618202
117MP0010352_gastrointestinal_tract_polyps0.91245816
118MP0005195_abnormal_posterior_eye0.91010769
119MP0002102_abnormal_ear_morphology0.90982876
120MP0005391_vision/eye_phenotype0.90433840
121MP0005174_abnormal_tail_pigmentation0.90167701
122MP0002184_abnormal_innervation0.89921459
123MP0000955_abnormal_spinal_cord0.89618679
124MP0002163_abnormal_gland_morphology0.89368436
125MP0004043_abnormal_pH_regulation0.89079412
126MP0002653_abnormal_ependyma_morphology0.88682288
127MP0009333_abnormal_splenocyte_physiolog0.88144348
128MP0003937_abnormal_limbs/digits/tail_de0.87460076
129MP0003755_abnormal_palate_morphology0.86508901
130MP0002095_abnormal_skin_pigmentation0.86503928
131MP0008872_abnormal_physiological_respon0.86225394
132MP0001501_abnormal_sleep_pattern0.85065978
133MP0002909_abnormal_adrenal_gland0.83992140
134MP0003690_abnormal_glial_cell0.83752912
135MP0002882_abnormal_neuron_morphology0.83638150
136MP0002398_abnormal_bone_marrow0.82748488
137MP0005025_abnormal_response_to0.81883983
138MP0005410_abnormal_fertilization0.80791617
139MP0001440_abnormal_grooming_behavior0.79381624
140MP0004782_abnormal_surfactant_physiolog0.79374511
141MP0000716_abnormal_immune_system0.79075947
142MP0001851_eye_inflammation0.77741665
143MP0001324_abnormal_eye_pigmentation0.76931633
144MP0003283_abnormal_digestive_organ0.76831680
145MP0000026_abnormal_inner_ear0.76553768
146MP0006054_spinal_hemorrhage0.76233635
147MP0003786_premature_aging0.76012837
148MP0003631_nervous_system_phenotype0.75339915
149MP0002006_tumorigenesis0.75145439
150MP0002069_abnormal_eating/drinking_beha0.74402587

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)7.17972154
2Thyroiditis (HP:0100646)3.86145830
3Pancreatic fibrosis (HP:0100732)3.59731899
4Medial flaring of the eyebrow (HP:0010747)3.58224149
5Arterial tortuosity (HP:0005116)3.45366627
6Gait imbalance (HP:0002141)3.45031714
7Abnormal hair whorl (HP:0010721)3.34842844
8Congenital primary aphakia (HP:0007707)3.31437461
9Neoplasm of the adrenal cortex (HP:0100641)3.31226175
10Intestinal atresia (HP:0011100)3.25383628
11Asymmetry of the thorax (HP:0001555)3.22102720
12Nephrogenic diabetes insipidus (HP:0009806)3.09238505
13Abnormality of cochlea (HP:0000375)3.03372025
14Thyroid carcinoma (HP:0002890)3.02764958
15True hermaphroditism (HP:0010459)3.01851489
16Renal cortical cysts (HP:0000803)2.97845250
17Abnormality of the renal cortex (HP:0011035)2.94136126
18Amblyopia (HP:0000646)2.88052904
19Methylmalonic acidemia (HP:0002912)2.83786136
20Orthostatic hypotension (HP:0001278)2.82316903
21Vascular tortuosity (HP:0004948)2.80368169
22Chronic hepatic failure (HP:0100626)2.80096619
23Volvulus (HP:0002580)2.76855508
24Abnormality of the labia minora (HP:0012880)2.75722194
25Progressive inability to walk (HP:0002505)2.73812190
26Abnormality of midbrain morphology (HP:0002418)2.69533834
27Molar tooth sign on MRI (HP:0002419)2.69533834
28Poor coordination (HP:0002370)2.62884361
29Vaginal atresia (HP:0000148)2.62851548
30Papillary thyroid carcinoma (HP:0002895)2.61786928
31Retinal dysplasia (HP:0007973)2.60378308
32Chronic diarrhea (HP:0002028)2.58625987
33Genital tract atresia (HP:0001827)2.56446783
34Hematochezia (HP:0002573)2.56078468
35Febrile seizures (HP:0002373)2.47591621
36Large for gestational age (HP:0001520)2.46821398
37Hemiparesis (HP:0001269)2.40459981
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40196560
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.40196560
40Morphological abnormality of the inner ear (HP:0011390)2.37514929
41Absent speech (HP:0001344)2.35189076
42Abnormality of incisor morphology (HP:0011063)2.35001319
43Aqueductal stenosis (HP:0002410)2.34451706
44Progressive macrocephaly (HP:0004481)2.33060061
45Lissencephaly (HP:0001339)2.32816112
46Hyperthyroidism (HP:0000836)2.30712573
47Neuroendocrine neoplasm (HP:0100634)2.28742836
48Pancreatic cysts (HP:0001737)2.28222963
49Type II lissencephaly (HP:0007260)2.27240368
50Heterochromia iridis (HP:0001100)2.27040462
51Recurrent abscess formation (HP:0002722)2.23876424
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.23798627
53Oligodactyly (hands) (HP:0001180)2.20660607
54Optic nerve hypoplasia (HP:0000609)2.17863663
55Polyphagia (HP:0002591)2.17282769
56Atonic seizures (HP:0010819)2.15655241
57Sensory axonal neuropathy (HP:0003390)2.14098528
58Spinal muscular atrophy (HP:0007269)2.13682867
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.13472199
60Poor speech (HP:0002465)2.13356542
61Stenosis of the external auditory canal (HP:0000402)2.13065682
62Abnormality of T cell number (HP:0011839)2.11451945
63T lymphocytopenia (HP:0005403)2.09417935
64Abnormality of the fingertips (HP:0001211)2.08352038
65Narrow forehead (HP:0000341)2.08204476
66Epileptic encephalopathy (HP:0200134)2.06780376
67Abolished electroretinogram (ERG) (HP:0000550)2.05934538
68Macroorchidism (HP:0000053)2.03462464
69Gaze-evoked nystagmus (HP:0000640)2.03027776
70Abnormality of the metopic suture (HP:0005556)2.02803261
71Short tibia (HP:0005736)2.01440294
72Attenuation of retinal blood vessels (HP:0007843)2.01026016
73Nephronophthisis (HP:0000090)1.99783097
74Methylmalonic aciduria (HP:0012120)1.99511665
75Pheochromocytoma (HP:0002666)1.99208166
76Broad foot (HP:0001769)1.97019631
77Focal motor seizures (HP:0011153)1.96988184
78Conjunctival hamartoma (HP:0100780)1.96759870
79Mask-like facies (HP:0000298)1.95595433
80Broad-based gait (HP:0002136)1.95518829
81Bile duct proliferation (HP:0001408)1.94879674
82Abnormal biliary tract physiology (HP:0012439)1.94879674
83Ketoacidosis (HP:0001993)1.93495862
84Gastrointestinal atresia (HP:0002589)1.92987144
85Septo-optic dysplasia (HP:0100842)1.92884032
86Abnormality of vitamin B metabolism (HP:0004340)1.92568207
87Flat capital femoral epiphysis (HP:0003370)1.92437299
88Akinesia (HP:0002304)1.92228410
89Hypsarrhythmia (HP:0002521)1.91743760
90Hyperventilation (HP:0002883)1.91433859
91Progressive cerebellar ataxia (HP:0002073)1.91177997
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90591806
93Hyperinsulinemic hypoglycemia (HP:0000825)1.90301921
943-Methylglutaconic aciduria (HP:0003535)1.89663514
95Spontaneous hematomas (HP:0007420)1.89590763
96Drooling (HP:0002307)1.88016948
97Excessive salivation (HP:0003781)1.88016948
98Cystic liver disease (HP:0006706)1.87940854
99Congenital stationary night blindness (HP:0007642)1.87698914
100Cutaneous melanoma (HP:0012056)1.86763850
101EEG with generalized epileptiform discharges (HP:0011198)1.86135217
102Aplasia/Hypoplasia of the fovea (HP:0008060)1.86003601
103Hypoplasia of the fovea (HP:0007750)1.86003601
104Abnormal rod and cone electroretinograms (HP:0008323)1.85933728
105Aplasia/Hypoplasia of the lens (HP:0008063)1.85879539
106Decreased lacrimation (HP:0000633)1.85649746
107IgM deficiency (HP:0002850)1.85508833
108Tubulointerstitial nephritis (HP:0001970)1.85369972
109Vasculitis (HP:0002633)1.85170072
110Decreased testicular size (HP:0008734)1.83663096
111Keratoconus (HP:0000563)1.82782559
112Increased corneal curvature (HP:0100692)1.82782559
113Recurrent bacterial skin infections (HP:0005406)1.82647465
114Furrowed tongue (HP:0000221)1.82356328
115Tinnitus (HP:0000360)1.82293266
116Epileptiform EEG discharges (HP:0011182)1.82063140
117Fair hair (HP:0002286)1.81844167
118Congenital hepatic fibrosis (HP:0002612)1.81287604
119Abnormal autonomic nervous system physiology (HP:0012332)1.80515571
120Occipital encephalocele (HP:0002085)1.79866694
121Anencephaly (HP:0002323)1.79533500
122Autoamputation (HP:0001218)1.78765113
123Hepatoblastoma (HP:0002884)1.78482758
124Prominent nasal bridge (HP:0000426)1.78258444
125Tented upper lip vermilion (HP:0010804)1.78242145
126Bifid tongue (HP:0010297)1.78209052
127Intention tremor (HP:0002080)1.77680433
128Focal seizures (HP:0007359)1.77625756
129Hypoglycemic coma (HP:0001325)1.76340585
130Cupped ear (HP:0000378)1.76258584
131Abnormality of the renal collecting system (HP:0004742)1.76257995
132Neoplasm of the adrenal gland (HP:0100631)1.76006269
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75533620
134Arterial thrombosis (HP:0004420)1.74467576
135Oculomotor apraxia (HP:0000657)1.73980998
136Abnormality of the pancreatic islet cells (HP:0006476)1.73603026
137Abnormality of endocrine pancreas physiology (HP:0012093)1.73603026
138Delayed closure of the anterior fontanelle (HP:0001476)1.73395533
139Pachygyria (HP:0001302)1.72884489
140Genetic anticipation (HP:0003743)1.72857431
141Agitation (HP:0000713)1.72803279
142Specific learning disability (HP:0001328)1.72199739
143Hyperglycinemia (HP:0002154)1.71637506
144Abnormality of the vitamin B12 metabolism (HP:0004341)1.70767397
145Pancreatic islet-cell hyperplasia (HP:0004510)1.70331970
146Renal hypoplasia (HP:0000089)1.69695756
147Tubular atrophy (HP:0000092)1.69563894
148Delayed gross motor development (HP:0002194)1.69141705
149Generalized myoclonic seizures (HP:0002123)1.69118830
150Widely spaced teeth (HP:0000687)1.68955129
151Sclerocornea (HP:0000647)1.68772619
152Abnormality of the corticospinal tract (HP:0002492)1.68754702
153Abnormality of the renal medulla (HP:0100957)1.68739493
154Type 2 muscle fiber atrophy (HP:0003554)1.68342645
155Inability to walk (HP:0002540)1.67426308
156Alacrima (HP:0000522)1.67368050
157Fetal akinesia sequence (HP:0001989)1.66103942
158Asthma (HP:0002099)1.65252953
159Lip pit (HP:0100267)1.63828562
160Esotropia (HP:0000565)1.63693241
161Nonprogressive disorder (HP:0003680)1.63460791
162Postaxial hand polydactyly (HP:0001162)1.63027446
163Hip dysplasia (HP:0001385)1.62112083
164Spondylolisthesis (HP:0003302)1.62086359
165Postaxial foot polydactyly (HP:0001830)1.60871629
166Abnormality of the intervertebral disk (HP:0005108)1.60528578
167Small epiphyses (HP:0010585)1.59325066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.87903068
2FGFR23.50977297
3MAP4K23.36190025
4MAP3K133.04075103
5PRPF4B2.88153619
6SIK32.82317213
7ERBB32.72398127
8TRIM282.67519312
9MAP3K142.51206399
10CASK2.25513269
11STK242.22787926
12TAOK32.06601644
13BMPR21.98813315
14FES1.94086389
15MAP2K71.89409622
16MAP3K41.81371256
17TXK1.80799119
18ARAF1.74410810
19ACVR1B1.71942932
20NUAK11.67603853
21MAP3K121.67493673
22EPHA41.61879922
23BMPR1B1.59648757
24MKNK21.59485161
25CDK81.59240433
26PLK21.59175318
27NEK91.53359560
28FGFR31.49600509
29MAPK131.43973631
30EIF2AK31.43800822
31GRK11.43178886
32MARK11.38832367
33BCR1.38094921
34JAK31.36203246
35CDK191.28758732
36MUSK1.24828765
37PAK31.23526394
38TNIK1.16431150
39MAP4K11.14192457
40NLK1.12936728
41NTRK31.12302939
42RIPK41.11086727
43CSNK1A1L1.10594597
44PNCK1.09758566
45AKT31.08826402
46PINK11.07838942
47YES11.06267786
48CSNK1G21.04916961
49STK391.04641216
50SGK4941.04067240
51SGK2231.04067240
52SGK21.04060495
53MARK31.03657655
54EPHA31.02943910
55OXSR11.02724800
56MAP3K60.99763105
57BRD40.97496885
58CSNK1G30.94419850
59KSR10.92876684
60MKNK10.92027276
61INSRR0.91992844
62CCNB10.91906839
63STK38L0.91094276
64MAP3K90.90313440
65EIF2AK10.88655538
66CAMKK20.88529116
67ZAK0.82723067
68SRPK10.81784240
69BCKDK0.81730600
70PRKCQ0.81370027
71PRKCG0.79386443
72MST40.78477742
73LCK0.76024542
74IRAK10.75758092
75MINK10.73988371
76IKBKB0.72056022
77PLK30.71289783
78SYK0.70995618
79PKN10.70228410
80BRSK20.69969093
81STK30.69781936
82DYRK30.69573979
83WNK40.67435145
84DMPK0.66557295
85PHKG10.66461600
86PHKG20.66461600
87VRK10.62920431
88JAK10.61801239
89FGR0.61228577
90DYRK1A0.60940643
91FER0.60106324
92RAF10.59897639
93TSSK60.59303525
94TRPM70.59088803
95IKBKE0.58942335
96PRKCH0.56620812
97PTK2B0.55868961
98PRKCE0.55093817
99IRAK40.54977622
100KSR20.52964166
101MAPKAPK50.52698770
102CSNK1G10.52491990
103SGK30.52178260
104LYN0.51133104
105CDK50.50580968
106CDK30.48395254
107MAP2K40.48357661
108CAMK2A0.48038639
109WNK30.47806918
110WNK10.47358173
111DYRK20.45360216
112NEK60.44242119
113ADRBK20.43883759
114IRAK20.43736297
115CAMK2B0.42948059
116GRK70.41651837
117RPS6KA40.41606927
118FGFR10.41425447
119ITK0.41263733
120TGFBR10.41139507
121PLK40.40493629
122DAPK20.39411078
123CHUK0.38586989
124ERBB40.38156807
125PASK0.38119860
126SGK10.37782045
127PRKG10.37202648
128TEC0.36863891
129PIK3CG0.36202564
130LIMK10.35296637
131ATM0.34912718
132NTRK20.34639582
133TYK20.34613596
134PLK10.34178060
135PRKACA0.33752186
136CSNK1D0.33338273
137ADRBK10.33245152
138TIE10.33117170
139NEK10.32616989
140DAPK10.32543603
141PRKACB0.32140410
142STK160.32027952
143CSNK1A10.31965781
144CAMK2D0.31044039
145HIPK20.30860703
146SIK20.30021093
147ROCK10.27834050
148HCK0.26679768
149BRAF0.26094625
150OBSCN0.26072454

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.41334507
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.01614224
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93352324
4Butanoate metabolism_Homo sapiens_hsa006502.54079660
5Protein export_Homo sapiens_hsa030602.50972499
6Propanoate metabolism_Homo sapiens_hsa006402.37354017
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.27742028
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16543813
9Collecting duct acid secretion_Homo sapiens_hsa049662.16403028
10Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.14983580
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08014317
12Synaptic vesicle cycle_Homo sapiens_hsa047211.89699671
13Olfactory transduction_Homo sapiens_hsa047401.81545456
14Rheumatoid arthritis_Homo sapiens_hsa053231.79616136
15Circadian rhythm_Homo sapiens_hsa047101.77114084
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73748072
17Non-homologous end-joining_Homo sapiens_hsa034501.72452324
18Fanconi anemia pathway_Homo sapiens_hsa034601.70892314
19Vibrio cholerae infection_Homo sapiens_hsa051101.59313421
20Serotonergic synapse_Homo sapiens_hsa047261.58239497
21Nitrogen metabolism_Homo sapiens_hsa009101.53166086
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51892960
23Selenocompound metabolism_Homo sapiens_hsa004501.50937131
24RNA degradation_Homo sapiens_hsa030181.46685314
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45263460
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41935740
27Basal transcription factors_Homo sapiens_hsa030221.40557319
28Peroxisome_Homo sapiens_hsa041461.39515199
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38397737
30Phototransduction_Homo sapiens_hsa047441.37299580
31Graft-versus-host disease_Homo sapiens_hsa053321.34428481
32Circadian entrainment_Homo sapiens_hsa047131.34021394
33Morphine addiction_Homo sapiens_hsa050321.32898246
34Phagosome_Homo sapiens_hsa041451.30790620
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29690858
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27170071
37Type I diabetes mellitus_Homo sapiens_hsa049401.26551474
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23369182
39Allograft rejection_Homo sapiens_hsa053301.22268697
40B cell receptor signaling pathway_Homo sapiens_hsa046621.21513164
41Fatty acid elongation_Homo sapiens_hsa000621.19111956
42Cholinergic synapse_Homo sapiens_hsa047251.17706766
43Chemokine signaling pathway_Homo sapiens_hsa040621.17373528
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.15682015
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15303945
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14561459
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.14470331
48Sulfur metabolism_Homo sapiens_hsa009201.14455385
49Glutamatergic synapse_Homo sapiens_hsa047241.14182868
50Oxidative phosphorylation_Homo sapiens_hsa001901.13537338
51Homologous recombination_Homo sapiens_hsa034401.13163992
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.12304013
53GABAergic synapse_Homo sapiens_hsa047271.12112746
54Dopaminergic synapse_Homo sapiens_hsa047281.12100068
55Linoleic acid metabolism_Homo sapiens_hsa005911.11572752
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11523319
57Primary immunodeficiency_Homo sapiens_hsa053401.09165047
58T cell receptor signaling pathway_Homo sapiens_hsa046601.07653727
59Nicotine addiction_Homo sapiens_hsa050331.06749626
60Autoimmune thyroid disease_Homo sapiens_hsa053201.06639269
61Renal cell carcinoma_Homo sapiens_hsa052111.02489135
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01004733
63Caffeine metabolism_Homo sapiens_hsa002320.99840250
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99611390
65Tryptophan metabolism_Homo sapiens_hsa003800.99091304
66Hedgehog signaling pathway_Homo sapiens_hsa043400.99056202
67Pancreatic cancer_Homo sapiens_hsa052120.96938790
68Dorso-ventral axis formation_Homo sapiens_hsa043200.96858648
69Legionellosis_Homo sapiens_hsa051340.96813188
70Inositol phosphate metabolism_Homo sapiens_hsa005620.96498779
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96472902
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93330944
73Long-term potentiation_Homo sapiens_hsa047200.93231921
74Pertussis_Homo sapiens_hsa051330.92312153
75Measles_Homo sapiens_hsa051620.91424121
76Osteoclast differentiation_Homo sapiens_hsa043800.89440215
77Leishmaniasis_Homo sapiens_hsa051400.87923139
78Oocyte meiosis_Homo sapiens_hsa041140.87838888
79Shigellosis_Homo sapiens_hsa051310.86226897
80Hematopoietic cell lineage_Homo sapiens_hsa046400.85414040
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83646355
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.81914930
83Salmonella infection_Homo sapiens_hsa051320.81909492
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81656434
85Fatty acid metabolism_Homo sapiens_hsa012120.81542858
86TNF signaling pathway_Homo sapiens_hsa046680.81322658
87Steroid biosynthesis_Homo sapiens_hsa001000.79820345
88Tuberculosis_Homo sapiens_hsa051520.79818560
89Taste transduction_Homo sapiens_hsa047420.79774790
90Ras signaling pathway_Homo sapiens_hsa040140.79648118
91Prostate cancer_Homo sapiens_hsa052150.79102962
92Prolactin signaling pathway_Homo sapiens_hsa049170.78783752
93Long-term depression_Homo sapiens_hsa047300.78589218
94Alcoholism_Homo sapiens_hsa050340.77454637
95Axon guidance_Homo sapiens_hsa043600.76830140
96Hepatitis C_Homo sapiens_hsa051600.76750523
97TGF-beta signaling pathway_Homo sapiens_hsa043500.76339071
98Amphetamine addiction_Homo sapiens_hsa050310.76040237
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75523083
100Viral myocarditis_Homo sapiens_hsa054160.75122280
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74193369
102Asthma_Homo sapiens_hsa053100.73554698
103Parkinsons disease_Homo sapiens_hsa050120.73444680
104Alzheimers disease_Homo sapiens_hsa050100.72753369
105Retinol metabolism_Homo sapiens_hsa008300.72226946
106Insulin secretion_Homo sapiens_hsa049110.71005597
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70418956
108Glioma_Homo sapiens_hsa052140.70142847
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69942208
110Renin secretion_Homo sapiens_hsa049240.69936276
111Ether lipid metabolism_Homo sapiens_hsa005650.69838537
112ABC transporters_Homo sapiens_hsa020100.69493671
113Hepatitis B_Homo sapiens_hsa051610.69366500
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.68787494
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68473391
116MAPK signaling pathway_Homo sapiens_hsa040100.68317965
117Toxoplasmosis_Homo sapiens_hsa051450.67749436
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67093109
119RNA polymerase_Homo sapiens_hsa030200.66946214
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66429377
121Influenza A_Homo sapiens_hsa051640.66018791
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64860728
123Malaria_Homo sapiens_hsa051440.62829005
124Apoptosis_Homo sapiens_hsa042100.61747993
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.61438510
126Herpes simplex infection_Homo sapiens_hsa051680.61327236
127ErbB signaling pathway_Homo sapiens_hsa040120.61023467
128Endometrial cancer_Homo sapiens_hsa052130.60978212
129Regulation of autophagy_Homo sapiens_hsa041400.60426877
130Cocaine addiction_Homo sapiens_hsa050300.60139325
131Epstein-Barr virus infection_Homo sapiens_hsa051690.59970897
132Chemical carcinogenesis_Homo sapiens_hsa052040.59454925
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59163900
134beta-Alanine metabolism_Homo sapiens_hsa004100.58570786
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58144524
136FoxO signaling pathway_Homo sapiens_hsa040680.57281119
137Melanoma_Homo sapiens_hsa052180.57145975
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56878987
139cAMP signaling pathway_Homo sapiens_hsa040240.56211016
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.55752042
141Proteasome_Homo sapiens_hsa030500.55736118
142Huntingtons disease_Homo sapiens_hsa050160.55592406
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54182774
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51581527
145Metabolic pathways_Homo sapiens_hsa011000.49760400
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.48202863
147Sphingolipid metabolism_Homo sapiens_hsa006000.48079210
148Wnt signaling pathway_Homo sapiens_hsa043100.47228644
149Cardiac muscle contraction_Homo sapiens_hsa042600.47101549
150Basal cell carcinoma_Homo sapiens_hsa052170.46498449
151Salivary secretion_Homo sapiens_hsa049700.45640575
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44131077
153Vitamin B6 metabolism_Homo sapiens_hsa007500.43023283
154Fatty acid degradation_Homo sapiens_hsa000710.41019076
155Hippo signaling pathway_Homo sapiens_hsa043900.40255755
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39134842
157Type II diabetes mellitus_Homo sapiens_hsa049300.39067259
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38667348
159Purine metabolism_Homo sapiens_hsa002300.37843440
160RNA transport_Homo sapiens_hsa030130.36604460
161Ovarian steroidogenesis_Homo sapiens_hsa049130.36498563
162Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35508605
163Calcium signaling pathway_Homo sapiens_hsa040200.34054378
164Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33000334
165Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.26317147
166Cysteine and methionine metabolism_Homo sapiens_hsa002700.25900601

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