KLHL29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.96716214
2synaptic vesicle maturation (GO:0016188)5.50109898
3locomotory exploration behavior (GO:0035641)5.44115258
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37695157
5vocalization behavior (GO:0071625)5.36146454
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24488914
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08988188
8synaptic vesicle exocytosis (GO:0016079)4.94599765
9regulation of glutamate receptor signaling pathway (GO:1900449)4.75874310
10glutamate secretion (GO:0014047)4.72823898
11protein localization to synapse (GO:0035418)4.70009886
12regulation of synaptic vesicle exocytosis (GO:2000300)4.61285644
13neuron cell-cell adhesion (GO:0007158)4.53302269
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.51115953
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.49795722
16layer formation in cerebral cortex (GO:0021819)4.47065280
17dendritic spine morphogenesis (GO:0060997)4.41888156
18exploration behavior (GO:0035640)4.36997910
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36659091
20regulation of synapse structural plasticity (GO:0051823)4.36476843
21regulation of neuronal synaptic plasticity (GO:0048168)4.33771289
22neuronal action potential propagation (GO:0019227)4.17761419
23neurotransmitter secretion (GO:0007269)4.08102159
24regulation of synaptic vesicle transport (GO:1902803)4.07742929
25glutamate receptor signaling pathway (GO:0007215)3.99540373
26neuron recognition (GO:0008038)3.93244917
27synaptic transmission, glutamatergic (GO:0035249)3.90448812
28neurotransmitter-gated ion channel clustering (GO:0072578)3.80759442
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80755325
30neuron-neuron synaptic transmission (GO:0007270)3.76033039
31axonal fasciculation (GO:0007413)3.75640130
32proline transport (GO:0015824)3.65726125
33regulation of dendritic spine morphogenesis (GO:0061001)3.64739871
34prepulse inhibition (GO:0060134)3.64408274
35neuronal ion channel clustering (GO:0045161)3.64345415
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63968168
37positive regulation of synapse maturation (GO:0090129)3.63758583
38long-term memory (GO:0007616)3.62582319
39transmission of nerve impulse (GO:0019226)3.56307183
40axon extension (GO:0048675)3.54338388
41positive regulation of membrane potential (GO:0045838)3.52793036
42gamma-aminobutyric acid transport (GO:0015812)3.50956087
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50928121
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50747654
45regulation of postsynaptic membrane potential (GO:0060078)3.45812913
46auditory behavior (GO:0031223)3.43218790
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42740572
48regulation of synaptic plasticity (GO:0048167)3.40771485
49neuromuscular process controlling balance (GO:0050885)3.39267501
50regulation of axon extension involved in axon guidance (GO:0048841)3.37229757
51dendrite morphogenesis (GO:0048813)3.35599024
52neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.34721337
53neurotransmitter transport (GO:0006836)3.32454615
54cellular potassium ion homeostasis (GO:0030007)3.31851219
55cell migration in hindbrain (GO:0021535)3.30786011
56regulation of vesicle fusion (GO:0031338)3.22785912
57mating behavior (GO:0007617)3.20834194
58regulation of axon guidance (GO:1902667)3.20125827
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.19373117
60kidney mesenchyme development (GO:0072074)3.18971173
61response to histamine (GO:0034776)3.18413585
62response to auditory stimulus (GO:0010996)3.17355084
63dendritic spine organization (GO:0097061)3.17208060
64presynaptic membrane organization (GO:0097090)3.15961624
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.15943542
66activation of protein kinase A activity (GO:0034199)3.15678908
67postsynaptic membrane organization (GO:0001941)3.15621972
68innervation (GO:0060384)3.13227325
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12670320
70regulation of neurotransmitter secretion (GO:0046928)3.12064388
71positive regulation of neurotransmitter transport (GO:0051590)3.10920946
72positive regulation of synapse assembly (GO:0051965)3.08404900
73positive regulation of dendritic spine development (GO:0060999)3.08376101
74neuron projection extension (GO:1990138)3.07696473
75negative regulation of catenin import into nucleus (GO:0035414)3.07650312
76positive regulation of neurotransmitter secretion (GO:0001956)3.07195754
77regulation of neurotransmitter levels (GO:0001505)3.06956589
78synapse assembly (GO:0007416)3.06361764
79neuron projection extension involved in neuron projection guidance (GO:1902284)3.06344512
80axon extension involved in axon guidance (GO:0048846)3.06344512
81sodium ion export (GO:0071436)3.06188377
82regulation of dendritic spine development (GO:0060998)3.05857471
83synaptic vesicle endocytosis (GO:0048488)3.04712540
84membrane depolarization (GO:0051899)3.04211189
85long-term synaptic potentiation (GO:0060291)3.04049040
86positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04047219
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.03867575
88learning (GO:0007612)3.02965335
89membrane depolarization during action potential (GO:0086010)3.02790231
90metanephric mesenchyme development (GO:0072075)3.01969865
91cerebellar Purkinje cell differentiation (GO:0021702)3.01821365
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01439685
93central nervous system projection neuron axonogenesis (GO:0021952)3.01377034
94adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00143127
95behavioral response to cocaine (GO:0048148)2.99817215
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98221445
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.98172817
98behavioral fear response (GO:0001662)2.97589019
99behavioral defense response (GO:0002209)2.97589019
100bone trabecula formation (GO:0060346)2.96624722
101hemidesmosome assembly (GO:0031581)2.96600525
102dopamine receptor signaling pathway (GO:0007212)2.96358733
103regulation of neurotransmitter transport (GO:0051588)2.95094058
104membrane hyperpolarization (GO:0060081)2.94732416
105intraspecies interaction between organisms (GO:0051703)2.94689039
106social behavior (GO:0035176)2.94689039
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91807386
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.90466728
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89661478
110semaphorin-plexin signaling pathway (GO:0071526)2.88987260
111presynaptic membrane assembly (GO:0097105)2.87193629
112synapse organization (GO:0050808)2.86573113
113glycine transport (GO:0015816)2.84012613
114cranial nerve morphogenesis (GO:0021602)2.83989927
115regulation of female receptivity (GO:0045924)2.83088123
116synaptic transmission, dopaminergic (GO:0001963)2.81435253
117planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74950418
118protein heterotrimerization (GO:0070208)2.70578046
119regulation of synapse assembly (GO:0051963)2.66938907
120positive regulation of axon extension (GO:0045773)2.66630567
121cerebellar granule cell differentiation (GO:0021707)2.65145387
122peristalsis (GO:0030432)2.64135044
123pyrimidine nucleobase catabolic process (GO:0006208)2.63511446
124ganglion development (GO:0061548)2.63103368
125negative regulation of axon extension involved in axon guidance (GO:0048843)2.62331034
126facial nerve structural organization (GO:0021612)2.60471226
127camera-type eye morphogenesis (GO:0048593)2.59080250
128collagen fibril organization (GO:0030199)2.55400649
129neuron remodeling (GO:0016322)2.54226391
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52638580
131mitochondrion transport along microtubule (GO:0047497)2.52638580
132negative regulation of axon guidance (GO:1902668)2.49515636
133neuron maturation (GO:0042551)2.49357098
134regulation of axon extension (GO:0030516)2.48622039
135establishment of mitochondrion localization (GO:0051654)2.46530444
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46380348
137membrane assembly (GO:0071709)2.45089475
138developmental cell growth (GO:0048588)2.42576837
139regulation of synapse organization (GO:0050807)2.37479677
140skin morphogenesis (GO:0043589)2.37170125
141mesenchymal-epithelial cell signaling (GO:0060638)2.34784891
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.34180586
143peripheral nervous system axon ensheathment (GO:0032292)2.31431226
144myelination in peripheral nervous system (GO:0022011)2.31431226
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31091468
146substrate-dependent cell migration (GO:0006929)2.30359626
147negative chemotaxis (GO:0050919)2.30090984
148cranial nerve structural organization (GO:0021604)2.29671862
149positive regulation of gastrulation (GO:2000543)2.29475330
150cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.29108551
151negative regulation of axon extension (GO:0030517)2.28582299
152cell-substrate junction assembly (GO:0007044)2.26523431
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26520630
154dopaminergic neuron differentiation (GO:0071542)2.26058231
155central nervous system neuron axonogenesis (GO:0021955)2.20007379
156negative regulation of fatty acid transport (GO:2000192)2.18662309
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.17627004
158regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.17062741
159developmental growth involved in morphogenesis (GO:0060560)2.16968760
160smooth muscle tissue development (GO:0048745)2.15987969
161regulation of establishment of planar polarity (GO:0090175)2.15607902
162nucleobase catabolic process (GO:0046113)2.15156181
163head development (GO:0060322)2.14926474
164paraxial mesoderm development (GO:0048339)2.12890534
165regulation of extent of cell growth (GO:0061387)2.12707174
166regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.11638201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00341943
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22240393
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13991258
4GBX2_23144817_ChIP-Seq_PC3_Human3.11504385
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11411014
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91208609
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91208609
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.81083674
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.73145591
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68925050
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61736292
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60659274
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58280147
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54326473
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50425298
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.47554775
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.44428947
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.41829883
19DROSHA_22980978_ChIP-Seq_HELA_Human2.39914824
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37470193
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36523425
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.33834959
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.14529299
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.11168977
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04584736
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.00254530
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98453968
28AR_21572438_ChIP-Seq_LNCaP_Human1.94654905
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91832672
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88779178
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88195104
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.87164706
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86225631
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84039763
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79705871
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.67436591
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61804222
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59393055
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57009633
40TAF15_26573619_Chip-Seq_HEK293_Human1.52804404
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50263343
42SMAD4_21799915_ChIP-Seq_A2780_Human1.47385556
43* RING1B_27294783_Chip-Seq_ESCs_Mouse1.46767091
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45652122
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43328597
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42363652
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.41997355
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38319772
49* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33048826
50* RING1B_27294783_Chip-Seq_NPCs_Mouse1.32366570
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.31532014
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30976309
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30535540
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.28784684
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.27387823
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27173095
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.23577957
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.23291902
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22993590
60P300_19829295_ChIP-Seq_ESCs_Human1.22622705
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21825495
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21402846
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21106983
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20882959
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20741671
66ZNF274_21170338_ChIP-Seq_K562_Hela1.20239983
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19796737
68AR_19668381_ChIP-Seq_PC3_Human1.18427094
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17187526
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.17134942
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16923260
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16797503
73KDM2B_26808549_Chip-Seq_K562_Human1.16148859
74* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16114451
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13592662
76* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13225292
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12659365
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12540583
79* AR_25329375_ChIP-Seq_VCAP_Human1.12485687
80RNF2_27304074_Chip-Seq_NSC_Mouse1.10796403
81* PIAS1_25552417_ChIP-Seq_VCAP_Human1.10427809
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09461864
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.08305494
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08282916
85AHR_22903824_ChIP-Seq_MCF-7_Human1.08212853
86IGF1R_20145208_ChIP-Seq_DFB_Human1.08002923
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07477303
88* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05942712
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05599330
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.05570198
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05451604
92STAT3_23295773_ChIP-Seq_U87_Human1.05382358
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.04889417
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04791273
95* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04319358
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02212603
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01928793
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.01681631
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00111848
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98165573
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97615830
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97575402
103TP53_16413492_ChIP-PET_HCT116_Human0.96249030
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93929409
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93929409
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.93924746
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.93892436
108* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93638482
109TP53_18474530_ChIP-ChIP_U2OS_Human0.93256694
110TCF4_23295773_ChIP-Seq_U87_Human0.93247846
111SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92942309
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92599795
113TP53_22127205_ChIP-Seq_IMR90_Human0.91917809
114UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90441195
115CTCF_27219007_Chip-Seq_Bcells_Human0.89960586
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.88934628
117CJUN_26792858_Chip-Seq_BT549_Human0.88289250
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88167065
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.88023268
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87986900
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87469300
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86164152
123TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85127893
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83999992
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83996721
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83746663
127BCAT_22108803_ChIP-Seq_LS180_Human0.83649084
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83498764
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80135720
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80084230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.38200355
2MP0003880_abnormal_central_pattern4.66044818
3MP0008438_abnormal_cutaneous_collagen4.22432495
4MP0003635_abnormal_synaptic_transmissio4.04617553
5MP0005503_abnormal_tendon_morphology3.60754867
6MP0004270_analgesia3.48935214
7MP0002063_abnormal_learning/memory/cond3.28217325
8MP0009745_abnormal_behavioral_response3.27856135
9MP0002822_catalepsy3.01721849
10MP0002064_seizures2.90137140
11MP0001968_abnormal_touch/_nociception2.87074088
12MP0005423_abnormal_somatic_nervous2.80977047
13MP0005275_abnormal_skin_tensile2.74696367
14MP0009046_muscle_twitch2.70943338
15MP0002572_abnormal_emotion/affect_behav2.68488222
16MP0002734_abnormal_mechanical_nocicepti2.54101382
17MP0005257_abnormal_intraocular_pressure2.53209422
18MP0001486_abnormal_startle_reflex2.50915964
19MP0000566_synostosis2.45985375
20MP0002272_abnormal_nervous_system2.39119615
21MP0003705_abnormal_hypodermis_morpholog2.29668085
22MP0002735_abnormal_chemical_nociception2.17669420
23MP0001501_abnormal_sleep_pattern2.16656757
24MP0002736_abnormal_nociception_after2.13083317
25MP0001440_abnormal_grooming_behavior2.04021497
26MP0000778_abnormal_nervous_system2.01855481
27MP0004272_abnormal_basement_membrane2.01422303
28MP0002184_abnormal_innervation1.95790743
29MP0002733_abnormal_thermal_nociception1.95789255
30MP0004858_abnormal_nervous_system1.92661554
31MP0006276_abnormal_autonomic_nervous1.91069787
32MP0009780_abnormal_chondrocyte_physiolo1.90169020
33MP0001970_abnormal_pain_threshold1.84065110
34MP0010030_abnormal_orbit_morphology1.83914278
35MP0002067_abnormal_sensory_capabilities1.83254973
36MP0002909_abnormal_adrenal_gland1.78820383
37MP0004811_abnormal_neuron_physiology1.77148172
38MP0002557_abnormal_social/conspecific_i1.76120465
39MP0001348_abnormal_lacrimal_gland1.68063877
40MP0008569_lethality_at_weaning1.66871651
41MP0001958_emphysema1.63986433
42MP0005386_behavior/neurological_phenoty1.60804016
43MP0004924_abnormal_behavior1.60804016
44MP0003329_amyloid_beta_deposits1.59397121
45MP0002108_abnormal_muscle_morphology1.58916412
46MP0003942_abnormal_urinary_system1.55844722
47MP0000955_abnormal_spinal_cord1.54047161
48MP0005171_absent_coat_pigmentation1.53427956
49MP0003879_abnormal_hair_cell1.51398099
50MP0003279_aneurysm1.49532422
51MP0002882_abnormal_neuron_morphology1.48822161
52MP0009250_abnormal_appendicular_skeleto1.47144771
53MP0009053_abnormal_anal_canal1.46463057
54MP0004885_abnormal_endolymph1.44094436
55MP0001984_abnormal_olfaction1.43794910
56MP0002249_abnormal_larynx_morphology1.39305715
57MP0000537_abnormal_urethra_morphology1.38470554
58MP0002066_abnormal_motor_capabilities/c1.36632958
59MP0005646_abnormal_pituitary_gland1.36499318
60MP0003122_maternal_imprinting1.34803997
61MP0000049_abnormal_middle_ear1.32586264
62MP0010368_abnormal_lymphatic_system1.31886895
63MP0005508_abnormal_skeleton_morphology1.30627130
64MP0001529_abnormal_vocalization1.28746195
65MP0005645_abnormal_hypothalamus_physiol1.28615134
66MP0000013_abnormal_adipose_tissue1.28192428
67MP0001502_abnormal_circadian_rhythm1.25771851
68MP0001188_hyperpigmentation1.24396304
69MP0003091_abnormal_cell_migration1.24250875
70MP0001905_abnormal_dopamine_level1.23786215
71MP0000733_abnormal_muscle_development1.20585651
72MP0001879_abnormal_lymphatic_vessel1.19978175
73MP0003787_abnormal_imprinting1.18762490
74MP0002295_abnormal_pulmonary_circulatio1.16591346
75MP0000579_abnormal_nail_morphology1.14810867
76MP0002152_abnormal_brain_morphology1.14655949
77MP0003633_abnormal_nervous_system1.11486922
78MP0005551_abnormal_eye_electrophysiolog1.11019491
79MP0000003_abnormal_adipose_tissue1.09548454
80MP0001177_atelectasis1.08760379
81MP0003115_abnormal_respiratory_system1.07610821
82MP0000751_myopathy1.06197337
83MP0002932_abnormal_joint_morphology1.05166556
84MP0002116_abnormal_craniofacial_bone1.03218013
85MP0003283_abnormal_digestive_organ1.03165251
86MP0004145_abnormal_muscle_electrophysio1.02932568
87MP0005394_taste/olfaction_phenotype1.01167709
88MP0005499_abnormal_olfactory_system1.01167709
89MP0000569_abnormal_digit_pigmentation1.01124697
90MP0000428_abnormal_craniofacial_morphol0.99854767
91MP0002177_abnormal_outer_ear0.99284199
92MP0004742_abnormal_vestibular_system0.98875693
93MP0009384_cardiac_valve_regurgitation0.98445980
94MP0000762_abnormal_tongue_morphology0.98037274
95MP0003566_abnormal_cell_adhesion0.95644936
96MP0003631_nervous_system_phenotype0.95258502
97MP0005623_abnormal_meninges_morphology0.94069205
98MP0002938_white_spotting0.93231248
99MP0010234_abnormal_vibrissa_follicle0.93168910
100MP0004142_abnormal_muscle_tone0.92989138
101MP0002069_abnormal_eating/drinking_beha0.91939558
102MP0000631_abnormal_neuroendocrine_gland0.91578559
103MP0003755_abnormal_palate_morphology0.91508919
104MP0003937_abnormal_limbs/digits/tail_de0.91476662
105MP0008872_abnormal_physiological_respon0.90125186
106MP0002229_neurodegeneration0.88708133
107MP0002060_abnormal_skin_morphology0.88607444
108MP0002752_abnormal_somatic_nervous0.88301712
109MP0001299_abnormal_eye_distance/0.88278447
110MP0002697_abnormal_eye_size0.87675285
111MP0002114_abnormal_axial_skeleton0.87286270
112MP0000767_abnormal_smooth_muscle0.86626373
113MP0001542_abnormal_bone_strength0.85238171
114MP0000462_abnormal_digestive_system0.83657188
115MP0003935_abnormal_craniofacial_develop0.83413429
116MP0005187_abnormal_penis_morphology0.83013647
117MP0005197_abnormal_uvea_morphology0.82882124
118MP0008961_abnormal_basal_metabolism0.82385466
119MP0002877_abnormal_melanocyte_morpholog0.82145601
120MP0002090_abnormal_vision0.80844270
121MP0002081_perinatal_lethality0.80710030
122MP0005409_darkened_coat_color0.80456480
123MP0000432_abnormal_head_morphology0.79310718
124MP0004085_abnormal_heartbeat0.79268221
125MP0002896_abnormal_bone_mineralization0.77493266
126MP0001963_abnormal_hearing_physiology0.77156079
127MP0003634_abnormal_glial_cell0.75228075
128MP0008874_decreased_physiological_sensi0.74973023
129MP0003861_abnormal_nervous_system0.73554351
130MP0001485_abnormal_pinna_reflex0.72142557
131MP0002638_abnormal_pupillary_reflex0.71131659
132MP0002234_abnormal_pharynx_morphology0.71100276
133MP0006072_abnormal_retinal_apoptosis0.69977100
134MP0000534_abnormal_ureter_morphology0.68165760
135MP0010386_abnormal_urinary_bladder0.67683858
136MP0005535_abnormal_body_temperature0.67617067
137MP0003632_abnormal_nervous_system0.67254756
138MP0003075_altered_response_to0.66698982
139MP0001346_abnormal_lacrimal_gland0.64433659
140MP0002102_abnormal_ear_morphology0.62359915
141MP0001943_abnormal_respiration0.61145741
142MP0003137_abnormal_impulse_conducting0.59254895
143MP0001664_abnormal_digestion0.58963782
144MP0000026_abnormal_inner_ear0.57768700
145MP0003690_abnormal_glial_cell0.57669582
146MP0003385_abnormal_body_wall0.56629567
147MP0010769_abnormal_survival0.53666339
148MP0005253_abnormal_eye_physiology0.53471429
149MP0000920_abnormal_myelination0.53266268
150MP0004233_abnormal_muscle_weight0.52953454

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.78699592
2Myokymia (HP:0002411)6.60500564
3Focal seizures (HP:0007359)5.38641967
4Visual hallucinations (HP:0002367)4.52822561
5Premature rupture of membranes (HP:0001788)4.19029912
6Epileptic encephalopathy (HP:0200134)4.14152243
7Protrusio acetabuli (HP:0003179)4.06687678
8Atonic seizures (HP:0010819)4.00350507
9Febrile seizures (HP:0002373)3.99130967
10Progressive cerebellar ataxia (HP:0002073)3.84969165
11Action tremor (HP:0002345)3.66973677
12Absence seizures (HP:0002121)3.63696981
13Atrophic scars (HP:0001075)3.52425181
14Broad-based gait (HP:0002136)3.48610277
15Generalized tonic-clonic seizures (HP:0002069)3.38258251
16Supranuclear gaze palsy (HP:0000605)3.29333771
17Dialeptic seizures (HP:0011146)3.28195794
18Bladder diverticulum (HP:0000015)3.25357269
19Ankle clonus (HP:0011448)3.22762246
20Shallow orbits (HP:0000586)3.12788974
21Poor eye contact (HP:0000817)3.12628209
22Amblyopia (HP:0000646)3.09943069
23Aortic dissection (HP:0002647)3.09820271
24Vascular tortuosity (HP:0004948)3.06338433
25Impaired vibration sensation in the lower limbs (HP:0002166)3.02502820
26Depression (HP:0000716)2.98984499
27Broad metatarsal (HP:0001783)2.94633618
28Dysdiadochokinesis (HP:0002075)2.91411542
29Impaired social interactions (HP:0000735)2.85203496
30Abnormal social behavior (HP:0012433)2.85203496
31Megalencephaly (HP:0001355)2.78780084
32Anxiety (HP:0000739)2.78097836
33Arterial tortuosity (HP:0005116)2.77221102
34Aortic aneurysm (HP:0004942)2.74986106
35Urinary bladder sphincter dysfunction (HP:0002839)2.74210219
36Mutism (HP:0002300)2.71886429
37Limb dystonia (HP:0002451)2.71310270
38Gaze-evoked nystagmus (HP:0000640)2.68526899
39Truncal ataxia (HP:0002078)2.67928834
40Soft skin (HP:0000977)2.67337244
41Hyperventilation (HP:0002883)2.66780449
42Ulnar bowing (HP:0003031)2.63904354
43Torticollis (HP:0000473)2.63166077
44Abnormal eating behavior (HP:0100738)2.62950485
45Fragile skin (HP:0001030)2.61189524
46Dysmetria (HP:0001310)2.57680020
47Papilledema (HP:0001085)2.57649894
48Hyperacusis (HP:0010780)2.51876448
49Overgrowth (HP:0001548)2.51438088
50Excessive salivation (HP:0003781)2.51195381
51Drooling (HP:0002307)2.51195381
52Spinal rigidity (HP:0003306)2.50676332
53Genetic anticipation (HP:0003743)2.50538272
54Termporal pattern (HP:0011008)2.49782835
55Insidious onset (HP:0003587)2.49782835
56Urinary urgency (HP:0000012)2.49310999
57Abnormality of the lower motor neuron (HP:0002366)2.45350691
58Progressive inability to walk (HP:0002505)2.44997939
59Stereotypic behavior (HP:0000733)2.43090533
60Postural instability (HP:0002172)2.42965990
61Ankle contracture (HP:0006466)2.41874949
62Broad face (HP:0000283)2.39909471
63Cerebral aneurysm (HP:0004944)2.37240843
64Cerebral inclusion bodies (HP:0100314)2.37115818
65Focal dystonia (HP:0004373)2.34880038
66Bowel diverticulosis (HP:0005222)2.33551738
67Abnormality of dentin (HP:0010299)2.30012651
68Hemiparesis (HP:0001269)2.29182388
69Obstructive sleep apnea (HP:0002870)2.28826390
70Neurofibrillary tangles (HP:0002185)2.27613659
71Morphological abnormality of the middle ear (HP:0008609)2.25317774
72Turricephaly (HP:0000262)2.23503243
73Wide anterior fontanel (HP:0000260)2.22127347
74Spastic gait (HP:0002064)2.20715182
75Genu recurvatum (HP:0002816)2.20700769
76Bell-shaped thorax (HP:0001591)2.18614780
77Renovascular hypertension (HP:0100817)2.18331906
78Mitral valve prolapse (HP:0001634)2.18115631
79Wormian bones (HP:0002645)2.18011310
80Aplasia involving bones of the upper limbs (HP:0009823)2.17722821
81Aplasia of the phalanges of the hand (HP:0009802)2.17722821
82Aplasia involving bones of the extremities (HP:0009825)2.17722821
83Intention tremor (HP:0002080)2.17302627
84Scanning speech (HP:0002168)2.17076563
85Abnormality of the corticospinal tract (HP:0002492)2.16548311
86Ventricular fibrillation (HP:0001663)2.16492139
87Craniofacial dystonia (HP:0012179)2.15422964
88Hypoventilation (HP:0002791)2.14786948
89Pointed chin (HP:0000307)2.14576979
90Type 1 muscle fiber predominance (HP:0003803)2.13727547
91Annular pancreas (HP:0001734)2.13524341
92Insomnia (HP:0100785)2.12716935
93Follicular hyperkeratosis (HP:0007502)2.10946256
94Aortic regurgitation (HP:0001659)2.10494278
95Neonatal short-limb short stature (HP:0008921)2.10333628
96Impaired smooth pursuit (HP:0007772)2.10174596
97Epileptiform EEG discharges (HP:0011182)2.09547937
98Bradykinesia (HP:0002067)2.09370496
99Wrist flexion contracture (HP:0001239)2.08347205
100Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05556275
101Short 4th metacarpal (HP:0010044)2.05556275
102Fetal akinesia sequence (HP:0001989)2.03340159
103Failure to thrive in infancy (HP:0001531)2.02808494
104Absent speech (HP:0001344)2.02616133
105Lower limb amyotrophy (HP:0007210)2.02282108
106EEG with generalized epileptiform discharges (HP:0011198)2.01401792
107Hyperextensible skin (HP:0000974)2.01193577
108Biconcave vertebral bodies (HP:0004586)2.01158777
109Lower limb muscle weakness (HP:0007340)2.00288868
110Hemiplegia (HP:0002301)1.99403260
111Polyphagia (HP:0002591)1.96055794
112Tracheomalacia (HP:0002779)1.95994302
113Shawl scrotum (HP:0000049)1.95442414
114Agitation (HP:0000713)1.94831431
115Coronal craniosynostosis (HP:0004440)1.93918538
116Hypoplasia of the iris (HP:0007676)1.93743381
117Mildly elevated creatine phosphokinase (HP:0008180)1.92951309
118Ankyloglossia (HP:0010296)1.92892535
119Hypsarrhythmia (HP:0002521)1.92246025
120Lower limb asymmetry (HP:0100559)1.91373164
121Elfin facies (HP:0004428)1.89750837
122Mitral regurgitation (HP:0001653)1.88357317
123Bronchomalacia (HP:0002780)1.86981165
124Natal tooth (HP:0000695)1.86419501
125Long eyelashes (HP:0000527)1.84962363
126Joint laxity (HP:0001388)1.84407014
127Exotropia (HP:0000577)1.84152805
128Abnormality of binocular vision (HP:0011514)1.84018813
129Diplopia (HP:0000651)1.84018813
130Sleep apnea (HP:0010535)1.83318419
131Pheochromocytoma (HP:0002666)1.83046576
132Flat cornea (HP:0007720)1.82047350
133Inability to walk (HP:0002540)1.80957547
134Abnormality of the aortic arch (HP:0012303)1.80333201
135Abnormality of ocular smooth pursuit (HP:0000617)1.80183551
136Renal duplication (HP:0000075)1.80015915
137Mild short stature (HP:0003502)1.79909300
138Laryngomalacia (HP:0001601)1.79739588
139Impaired vibratory sensation (HP:0002495)1.79725220
140Incomplete penetrance (HP:0003829)1.78190694
141Cervical subluxation (HP:0003308)1.75491965
142Dysmetric saccades (HP:0000641)1.75138921
143Abnormality of salivation (HP:0100755)1.74311406
144Overriding aorta (HP:0002623)1.73477523
145Deviation of the hallux (HP:0010051)1.72379287
146Rapidly progressive (HP:0003678)1.72169493
147Hyperthyroidism (HP:0000836)1.71932344
148Limited hip movement (HP:0008800)1.71086685
149Blue sclerae (HP:0000592)1.70881875
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70822505
151Thickened helices (HP:0000391)1.70565605
152Aqueductal stenosis (HP:0002410)1.70420396
153Status epilepticus (HP:0002133)1.68544182
154Generalized myoclonic seizures (HP:0002123)1.67927574
155Amyotrophic lateral sclerosis (HP:0007354)1.66253539
156Disproportionate tall stature (HP:0001519)1.65456160
157Long toe (HP:0010511)1.65373601
158Inappropriate behavior (HP:0000719)1.65162173
159Hallux valgus (HP:0001822)1.65082810
160Short nail (HP:0001799)1.64642487
161Hypoplastic ischia (HP:0003175)1.64414616
162Abnormality of the radial head (HP:0003995)1.63133899
163Cutaneous finger syndactyly (HP:0010554)1.62979980
164Bowing of the arm (HP:0006488)1.61912477
165Bowed forearm bones (HP:0003956)1.61912477
166Abnormal EKG (HP:0003115)1.61909251
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.61756551
168Abnormality of the ischium (HP:0003174)1.61536042
169Long palpebral fissure (HP:0000637)1.61466474
170Short clavicles (HP:0000894)1.56836011
171Dislocated radial head (HP:0003083)1.56735092
172Vitreoretinal degeneration (HP:0000655)1.55928536
173Buphthalmos (HP:0000557)1.55035912
174Megalocornea (HP:0000485)1.53890519
175Slender build (HP:0001533)1.53856804
176Abnormality of the anterior chamber (HP:0000593)1.53149353
177Aneurysm (HP:0002617)1.53007704
178Abnormality of the phalanges of the hallux (HP:0010057)1.52802189
179Abnormality of the 4th metacarpal (HP:0010012)1.52505827
180Cutaneous syndactyly (HP:0012725)1.52096941
181Arnold-Chiari malformation (HP:0002308)1.51960205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.64366214
2NTRK34.26289053
3MAP3K93.81894192
4MARK13.44627892
5TRIB33.34320542
6MINK12.70362086
7MAP3K42.65084502
8DAPK22.63991977
9NTRK22.30131931
10PAK62.25947309
11ICK2.08937702
12MAP2K72.08893697
13KSR22.03876275
14NTRK11.97917531
15PRKD31.95596652
16KSR11.81512503
17RIPK41.78584425
18LATS11.71994183
19PTK21.70889784
20CAMKK11.69990589
21AKT31.66413420
22CDK51.61846446
23MAP2K41.61000743
24SIK11.59902183
25CDK121.57116582
26MAP3K61.54145257
27CASK1.52378266
28SIK21.51680178
29TTN1.48047887
30MAPK131.46386408
31CAMK1D1.41939325
32PNCK1.38120207
33TYRO31.35133856
34INSRR1.34738750
35TNIK1.33854951
36MYLK1.32866975
37PRPF4B1.30540892
38UHMK11.30038056
39LATS21.29820236
40MAP3K121.28435287
41DAPK11.28378463
42MET1.27996945
43MST1R1.23500098
44GRK51.22383925
45FES1.18648341
46STK381.17611756
47MTOR1.15954870
48PLK21.15203660
49TAOK11.14456451
50EEF2K1.13506774
51MAP3K21.08983978
52PRKCG1.08685777
53PAK21.08680485
54ARAF1.07745341
55PDGFRB1.05816427
56EPHA21.05549962
57EPHB11.03865800
58PHKG21.02744947
59PHKG11.02744947
60EPHA30.99745256
61STK110.97439701
62RET0.96311559
63CAMK2A0.95502233
64CDK180.94100432
65PKN20.93936280
66CDK150.92538750
67CDK140.91851593
68CDK190.90756501
69PAK30.90647659
70DYRK20.89588718
71SGK2230.89363246
72SGK4940.89363246
73PTK2B0.87654418
74FGFR20.86375863
75CAMK10.85009238
76PRKCH0.82612465
77MAP3K130.80861862
78CDK11A0.80117029
79CSNK1G20.79636058
80FER0.78516875
81GRK10.78214128
82CAMK2B0.77168192
83DDR20.74463353
84CAMKK20.73148135
85LMTK20.71700389
86BMPR20.71696863
87PINK10.71353515
88SGK20.71013482
89TNK20.70789113
90DYRK1A0.69396733
91ERBB40.69352313
92MARK20.68573688
93ADRBK10.67940212
94RAF10.67363658
95SGK10.67027494
96ALK0.65952285
97MAP3K70.65638345
98CAMK1G0.64649700
99PKN10.62824455
100PDGFRA0.61218871
101MAPK120.59803312
102IRAK20.59773230
103MAP3K100.59577644
104EPHB20.57751932
105SGK30.57641042
106PRKCZ0.54995570
107RIPK10.51551934
108OXSR10.50671625
109MAP2K10.50308266
110BRD40.50300599
111PRKAA10.49685730
112DMPK0.49229557
113CDC42BPA0.48878839
114RPS6KA30.48850992
115PDPK10.48381852
116PRKCE0.47544719
117RPS6KA20.47448337
118ABL20.46865416
119FYN0.46834214
120ILK0.46401319
121BMPR1B0.46107281
122MAPK100.45595904
123GSK3A0.43877023
124MAP3K10.42894787
125PDK10.42782470
126CAMK40.41771592
127PRKD20.38636703
128WNK10.38585695
129BCR0.38578613
130MOS0.38249174
131CAMK2D0.37903881
132CAMK2G0.36951956
133LIMK10.35948032
134FGR0.35835113
135BRAF0.35389847
136ROCK10.34190810
137ROCK20.33934530
138ERBB30.33798297
139CDK80.33403072

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45550193
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98233844
3Olfactory transduction_Homo sapiens_hsa047402.73827744
4Circadian entrainment_Homo sapiens_hsa047132.59500938
5Long-term potentiation_Homo sapiens_hsa047202.55295364
6GABAergic synapse_Homo sapiens_hsa047272.53203475
7Glutamatergic synapse_Homo sapiens_hsa047242.49148839
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48359613
9Amphetamine addiction_Homo sapiens_hsa050312.44330538
10Morphine addiction_Homo sapiens_hsa050322.35286018
11ECM-receptor interaction_Homo sapiens_hsa045122.27032095
12Dopaminergic synapse_Homo sapiens_hsa047282.23822772
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08510404
14Salivary secretion_Homo sapiens_hsa049702.04857115
15Cholinergic synapse_Homo sapiens_hsa047251.93945512
16Cocaine addiction_Homo sapiens_hsa050301.90618114
17Insulin secretion_Homo sapiens_hsa049111.81911242
18Gastric acid secretion_Homo sapiens_hsa049711.81837372
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79975656
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68907846
21Renin secretion_Homo sapiens_hsa049241.67015286
22Serotonergic synapse_Homo sapiens_hsa047261.66514246
23Oxytocin signaling pathway_Homo sapiens_hsa049211.66025618
24Taste transduction_Homo sapiens_hsa047421.65859026
25Focal adhesion_Homo sapiens_hsa045101.65594085
26Long-term depression_Homo sapiens_hsa047301.65480714
27Basal cell carcinoma_Homo sapiens_hsa052171.63040206
28Calcium signaling pathway_Homo sapiens_hsa040201.53556659
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53525458
30GnRH signaling pathway_Homo sapiens_hsa049121.45993745
31Axon guidance_Homo sapiens_hsa043601.45870086
32Gap junction_Homo sapiens_hsa045401.44429532
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40143609
34Phototransduction_Homo sapiens_hsa047441.38565344
35cAMP signaling pathway_Homo sapiens_hsa040241.27036779
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26710067
37Glioma_Homo sapiens_hsa052141.25975022
38Estrogen signaling pathway_Homo sapiens_hsa049151.20248612
39Melanogenesis_Homo sapiens_hsa049161.19282673
40Type II diabetes mellitus_Homo sapiens_hsa049301.17367772
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14328569
42Notch signaling pathway_Homo sapiens_hsa043301.13315272
43ErbB signaling pathway_Homo sapiens_hsa040121.12791466
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09039145
45Adherens junction_Homo sapiens_hsa045201.08901298
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08576729
47Proteoglycans in cancer_Homo sapiens_hsa052051.08073995
48Protein digestion and absorption_Homo sapiens_hsa049741.07054755
49Vitamin B6 metabolism_Homo sapiens_hsa007501.06719845
50Collecting duct acid secretion_Homo sapiens_hsa049661.05284168
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04913560
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03413976
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01836541
54MicroRNAs in cancer_Homo sapiens_hsa052060.99071375
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96104293
56Cardiac muscle contraction_Homo sapiens_hsa042600.95166361
57Dorso-ventral axis formation_Homo sapiens_hsa043200.92792609
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91576020
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.91302264
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.89016299
61Amoebiasis_Homo sapiens_hsa051460.88571875
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86840098
63Oocyte meiosis_Homo sapiens_hsa041140.85724352
64Small cell lung cancer_Homo sapiens_hsa052220.85263887
65Pathways in cancer_Homo sapiens_hsa052000.84860700
66Chronic myeloid leukemia_Homo sapiens_hsa052200.83269591
67Lysine degradation_Homo sapiens_hsa003100.80789452
68AMPK signaling pathway_Homo sapiens_hsa041520.80225415
69Dilated cardiomyopathy_Homo sapiens_hsa054140.79519531
70Choline metabolism in cancer_Homo sapiens_hsa052310.79218847
71PI3K-Akt signaling pathway_Homo sapiens_hsa041510.78669499
72VEGF signaling pathway_Homo sapiens_hsa043700.77090392
73MAPK signaling pathway_Homo sapiens_hsa040100.75771320
74Pancreatic secretion_Homo sapiens_hsa049720.74829977
75TGF-beta signaling pathway_Homo sapiens_hsa043500.73101069
76Rap1 signaling pathway_Homo sapiens_hsa040150.72514450
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.70984986
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70928178
79Thyroid hormone synthesis_Homo sapiens_hsa049180.69066775
80Vibrio cholerae infection_Homo sapiens_hsa051100.68731408
81Prostate cancer_Homo sapiens_hsa052150.68633310
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68207430
83Endometrial cancer_Homo sapiens_hsa052130.67831454
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67450974
85Prolactin signaling pathway_Homo sapiens_hsa049170.66098979
86Ras signaling pathway_Homo sapiens_hsa040140.65056783
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63555615
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63417641
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63149524
90Renal cell carcinoma_Homo sapiens_hsa052110.61935347
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61407225
92Wnt signaling pathway_Homo sapiens_hsa043100.61357308
93Alcoholism_Homo sapiens_hsa050340.61350354
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60950133
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58743110
96Non-small cell lung cancer_Homo sapiens_hsa052230.57513063
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57080578
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.56902376
99mTOR signaling pathway_Homo sapiens_hsa041500.56020143
100Nitrogen metabolism_Homo sapiens_hsa009100.55891432
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54833855
102Glucagon signaling pathway_Homo sapiens_hsa049220.49942735
103Prion diseases_Homo sapiens_hsa050200.49796434
104Endocytosis_Homo sapiens_hsa041440.49500708
105Insulin signaling pathway_Homo sapiens_hsa049100.47317315
106Inositol phosphate metabolism_Homo sapiens_hsa005620.44173561
107Hedgehog signaling pathway_Homo sapiens_hsa043400.43639087
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43282165
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42957690
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42408087
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41241311
112Circadian rhythm_Homo sapiens_hsa047100.40389397
113Bile secretion_Homo sapiens_hsa049760.39723557
114Colorectal cancer_Homo sapiens_hsa052100.38747393
115Ovarian steroidogenesis_Homo sapiens_hsa049130.36351749
116Tight junction_Homo sapiens_hsa045300.36336214
117Hippo signaling pathway_Homo sapiens_hsa043900.36157417
118Melanoma_Homo sapiens_hsa052180.34198851
119Chemokine signaling pathway_Homo sapiens_hsa040620.33520486
120Type I diabetes mellitus_Homo sapiens_hsa049400.33049953
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.32322477
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30895537
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30055752

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