ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	7.98312542
2	L-phenylalanine catabolic process (GO:0006559)	5.55956020
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.55956020
4	L-phenylalanine metabolic process (GO:0006558)	5.28111768
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.28111768
6	negative regulation of fibrinolysis (GO:0051918)	4.93081841
7	cellular response to zinc ion (GO:0071294)	4.83640837
8	regulation of cholesterol esterification (GO:0010872)	4.71764910
9	regulation of protein activation cascade (GO:2000257)	4.59914838
10	phospholipid efflux (GO:0033700)	4.58478582
11	regulation of fibrinolysis (GO:0051917)	4.49653842
12	lipopolysaccharide metabolic process (GO:0008653)	4.49594279
13	phenylpropanoid metabolic process (GO:0009698)	4.48709218
14	lipopolysaccharide biosynthetic process (GO:0009103)	4.40528255
15	mannosylation (GO:0097502)	4.22953574
16	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.17064714
17	regulation of triglyceride catabolic process (GO:0010896)	4.14806887
18	N-acetylneuraminate metabolic process (GO:0006054)	4.10021333
19	proline metabolic process (GO:0006560)	4.03621807
20	negative regulation of execution phase of apoptosis (GO:1900118)	4.03231556
21	negative regulation of protein activation cascade (GO:2000258)	4.03226572
22	regulation of complement activation (GO:0030449)	4.02700044
23	negative regulation of complement activation (GO:0045916)	4.02311322
24	regulation of lipoprotein particle clearance (GO:0010984)	4.01251222
25	base-excision repair, AP site formation (GO:0006285)	3.97009203
26	serine family amino acid catabolic process (GO:0009071)	3.91853307
27	peptidyl-glutamic acid carboxylation (GO:0017187)	3.89285715
28	protein carboxylation (GO:0018214)	3.89285715
29	protein maturation by protein folding (GO:0022417)	3.89187000
30	blood coagulation, intrinsic pathway (GO:0007597)	3.82620144
31	membrane budding (GO:0006900)	3.79157002
32	negative regulation of humoral immune response (GO:0002921)	3.78459161
33	very-low-density lipoprotein particle assembly (GO:0034379)	3.76355278
34	sodium-independent organic anion transport (GO:0043252)	3.76198387
35	positive regulation of endothelial cell differentiation (GO:0045603)	3.74688485
36	regulation of penile erection (GO:0060405)	3.71702983
37	GPI anchor biosynthetic process (GO:0006506)	3.65582927
38	fibrinolysis (GO:0042730)	3.62993565
39	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.62886442
40	cytolysis (GO:0019835)	3.62413319
41	GPI anchor metabolic process (GO:0006505)	3.46862593
42	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.46636603
43	pyrimidine nucleotide catabolic process (GO:0006244)	3.38307446
44	prenylation (GO:0097354)	3.34961845
45	protein prenylation (GO:0018342)	3.34961845
46	aggressive behavior (GO:0002118)	3.31909262
47	T cell migration (GO:0072678)	3.31866924
48	glycine metabolic process (GO:0006544)	3.27687948
49	plasma lipoprotein particle remodeling (GO:0034369)	3.27066997
50	protein-lipid complex remodeling (GO:0034368)	3.27066997
51	macromolecular complex remodeling (GO:0034367)	3.27066997
52	serine family amino acid biosynthetic process (GO:0009070)	3.24308431
53	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.23515351
54	serine family amino acid metabolic process (GO:0009069)	3.23455432
55	seminiferous tubule development (GO:0072520)	3.20201199
56	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.20102719
57	protein K11-linked deubiquitination (GO:0035871)	3.19564615
58	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.19347672
59	high-density lipoprotein particle remodeling (GO:0034375)	3.17053542
60	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	3.16364442
61	interkinetic nuclear migration (GO:0022027)	3.15403838
62	positive regulation of cellular amine metabolic process (GO:0033240)	3.13299349
63	cholesterol efflux (GO:0033344)	3.11368615
64	cellular response to virus (GO:0098586)	3.10909159
65	triglyceride homeostasis (GO:0070328)	3.05472582
66	acylglycerol homeostasis (GO:0055090)	3.05472582
67	negative regulation of cholesterol transport (GO:0032375)	3.04770328
68	negative regulation of sterol transport (GO:0032372)	3.04770328
69	cellular glucuronidation (GO:0052695)	3.02994573
70	plasma lipoprotein particle assembly (GO:0034377)	3.02028423
71	carnitine metabolic process (GO:0009437)	2.99132486
72	steroid catabolic process (GO:0006706)	2.96589467
73	negative regulation of lipase activity (GO:0060192)	2.95890518
74	complement activation, alternative pathway (GO:0006957)	2.94409886
75	arginine catabolic process (GO:0006527)	2.89885935
76	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.88257803
77	amino-acid betaine metabolic process (GO:0006577)	2.88252906
78	hyperosmotic salinity response (GO:0042538)	2.87989357
79	regulation of plasminogen activation (GO:0010755)	2.87308612
80	aromatic amino acid family catabolic process (GO:0009074)	2.86394913
81	positive regulation of triglyceride lipase activity (GO:0061365)	2.84523499
82	positive regulation of lipoprotein lipase activity (GO:0051006)	2.84523499
83	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.82774986
84	cellular anion homeostasis (GO:0030002)	2.82202682
85	purine ribonucleotide transport (GO:0015868)	2.81059769
86	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.80140145
87	hormone catabolic process (GO:0042447)	2.77921607
88	regulation of fatty acid biosynthetic process (GO:0042304)	2.77839039
89	regulation of interferon-beta biosynthetic process (GO:0045357)	2.76852738
90	glucuronate metabolic process (GO:0019585)	2.76152154
91	uronic acid metabolic process (GO:0006063)	2.76152154
92	thyroid hormone generation (GO:0006590)	2.73938546
93	heme transport (GO:0015886)	2.73704364
94	reverse cholesterol transport (GO:0043691)	2.72421916
95	hepatocyte differentiation (GO:0070365)	2.71954803
96	positive regulation of guanylate cyclase activity (GO:0031284)	2.71754875
97	regulation of mitochondrial translation (GO:0070129)	2.71655061
98	bile acid and bile salt transport (GO:0015721)	2.70995597
99	L-serine metabolic process (GO:0006563)	2.70694927
100	trivalent inorganic anion homeostasis (GO:0072506)	2.70210244

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.12511813
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.63666603
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.55001488
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.36129591
5	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.24434732
6	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.82612217
7	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.47520906
8	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.38964341
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.36994220
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.32092034
11	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.32081684
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.23031238
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.21310498
14	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.18225109
15	HTT_18923047_ChIP-ChIP_STHdh_Human	2.15309272
16	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	2.15108584
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.13308776
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.12630531
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08715095
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.05686225
21	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.02794453
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.99345402
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92599207
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.90551857
25	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.85289513
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84711799
27	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.83691939
28	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.77369690
29	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.75185653
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.74595331
31	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.70619804
32	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.58774057
33	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.58476741
34	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.57304004
35	P300_27268052_Chip-Seq_Bcells_Human	1.56695244
36	P53_21459846_ChIP-Seq_SAOS-2_Human	1.56112875
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.51286191
38	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.43868384
39	BCOR_27268052_Chip-Seq_Bcells_Human	1.43007601
40	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.40532452
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37028379
42	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.36986707
43	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.36890326
44	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.34970735
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.34783115
46	E2F1_20622854_ChIP-Seq_HELA_Human	1.32344762
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.32244133
48	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.31318766
49	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.30106100
50	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.29925090
51	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.29687791
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27667199
53	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.25080841
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24804658
55	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.24343363
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.24342567
57	RAC3_21632823_ChIP-Seq_H3396_Human	1.23185738
58	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.21465271
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21040794
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.20576197
61	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.18383104
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17412054
63	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17073061
64	SPI1_20517297_ChIP-Seq_HL60_Human	1.16941046
65	BCL6_27268052_Chip-Seq_Bcells_Human	1.16032154
66	OCT4_20526341_ChIP-Seq_ESCs_Human	1.15837495
67	VDR_23849224_ChIP-Seq_CD4+_Human	1.15509609
68	AR_21909140_ChIP-Seq_LNCAP_Human	1.15355716
69	PHF8_20622854_ChIP-Seq_HELA_Human	1.15218232
70	PHF8_20622853_ChIP-Seq_HELA_Human	1.14886918
71	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14724272
72	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.14398147
73	SCL_19346495_ChIP-Seq_HPC-7_Human	1.13025556
74	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.12666565
75	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11858854
76	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.10171066
77	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.07709230
78	CSB_26484114_Chip-Seq_FIBROBLAST_Human	1.07517942
79	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.07134539
80	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06873071
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04687273
82	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03498371
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.02063210
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01343020
85	BCAT_22108803_ChIP-Seq_LS180_Human	1.01011507
86	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.00920437
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00806753
88	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00293526
89	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.99809080
90	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.98652837
91	ETV1_20927104_ChIP-Seq_GIST48_Human	0.98419746
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97375868
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97281760
94	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.96120497
95	NFYA_21822215_ChIP-Seq_K562_Human	0.95855294
96	UTX_26944678_Chip-Seq_JUKART_Human	0.95801025
97	DCP1A_22483619_ChIP-Seq_HELA_Human	0.95648861
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.95270692
99	SPI1_26923725_Chip-Seq_HPCs_Mouse	0.95138011
100	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.94986345

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.53464766
2	MP0005360_urolithiasis	6.93815576
3	MP0005645_abnormal_hypothalamus_physiol	4.62008491
4	MP0003806_abnormal_nucleotide_metabolis	4.42414370
5	MP0009697_abnormal_copulation	4.34062485
6	MP0003191_abnormal_cellular_cholesterol	3.10028755
7	MP0008875_abnormal_xenobiotic_pharmacok	2.82916499
8	MP0003195_calcinosis	2.75744255
9	MP0005085_abnormal_gallbladder_physiolo	2.43300105
10	MP0003950_abnormal_plasma_membrane	2.40603043
11	MP0008004_abnormal_stomach_pH	2.37035871
12	MP0003252_abnormal_bile_duct	2.33357344
13	MP0003868_abnormal_feces_composition	2.32337807
14	MP0002653_abnormal_ependyma_morphology	2.17708344
15	MP0005365_abnormal_bile_salt	2.07250711
16	MP0002138_abnormal_hepatobiliary_system	2.02743953
17	MP0008260_abnormal_autophagy	2.00814223
18	MP0003786_premature_aging	1.76097471
19	MP0009840_abnormal_foam_cell	1.75985136
20	MP0005332_abnormal_amino_acid	1.74300404
21	MP0005058_abnormal_lysosome_morphology	1.72218254
22	MP0005646_abnormal_pituitary_gland	1.67308087
23	MP0002876_abnormal_thyroid_physiology	1.63512339
24	MP0003045_fibrosis	1.49518080
25	MP0000678_abnormal_parathyroid_gland	1.49149675
26	MP0005410_abnormal_fertilization	1.47153102
27	MP0008007_abnormal_cellular_replicative	1.46401614
28	MP0003638_abnormal_response/metabolism_	1.46061616
29	MP0001764_abnormal_homeostasis	1.44903290
30	MP0001666_abnormal_nutrient_absorption	1.37541957
31	MP0002928_abnormal_bile_duct	1.36884465
32	MP0004043_abnormal_pH_regulation	1.35555368
33	MP0009643_abnormal_urine_homeostasis	1.30179798
34	MP0005671_abnormal_response_to	1.26794297
35	MP0005167_abnormal_blood-brain_barrier	1.24661791
36	MP0003718_maternal_effect	1.24389708
37	MP0006036_abnormal_mitochondrial_physio	1.21803726
38	MP0010329_abnormal_lipoprotein_level	1.16956189
39	MP0001915_intracranial_hemorrhage	1.16413038
40	MP0005395_other_phenotype	1.15828213
41	MP0003186_abnormal_redox_activity	1.07501740
42	MP0000609_abnormal_liver_physiology	1.04864160
43	MP0004782_abnormal_surfactant_physiolog	1.04734308
44	MP0005636_abnormal_mineral_homeostasis	1.04072655
45	MP0004264_abnormal_extraembryonic_tissu	0.99144706
46	MP0009785_altered_susceptibility_to	0.95772883
47	MP0010386_abnormal_urinary_bladder	0.95080802
48	MP0002168_other_aberrant_phenotype	0.93807039
49	MP0002118_abnormal_lipid_homeostasis	0.93580653
50	MP0000598_abnormal_liver_morphology	0.90093988
51	MP0005408_hypopigmentation	0.88651813
52	MP0008469_abnormal_protein_level	0.88298734
53	MP0005551_abnormal_eye_electrophysiolog	0.88281132
54	MP0005397_hematopoietic_system_phenotyp	0.88038098
55	MP0001545_abnormal_hematopoietic_system	0.88038098
56	MP0008058_abnormal_DNA_repair	0.85944414
57	MP0005187_abnormal_penis_morphology	0.85788197
58	MP0002090_abnormal_vision	0.84542122
59	MP0000013_abnormal_adipose_tissue	0.83960933
60	MP0002166_altered_tumor_susceptibility	0.83727455
61	MP0005376_homeostasis/metabolism_phenot	0.83124162
62	MP0005464_abnormal_platelet_physiology	0.80406116
63	MP0002396_abnormal_hematopoietic_system	0.79950366
64	MP0010368_abnormal_lymphatic_system	0.78631832
65	MP0002638_abnormal_pupillary_reflex	0.78513466
66	MP0008995_early_reproductive_senescence	0.77564629
67	MP0009642_abnormal_blood_homeostasis	0.76713839
68	MP0006035_abnormal_mitochondrial_morpho	0.76696114
69	MP0008872_abnormal_physiological_respon	0.76538921
70	MP0006276_abnormal_autonomic_nervous	0.74597662
71	MP0005266_abnormal_metabolism	0.74590473
72	MP0006054_spinal_hemorrhage	0.74523020
73	MP0005084_abnormal_gallbladder_morpholo	0.74503214
74	MP0002132_abnormal_respiratory_system	0.70477294
75	MP0001929_abnormal_gametogenesis	0.70231486
76	MP0003698_abnormal_male_reproductive	0.67948175
77	MP0001845_abnormal_inflammatory_respons	0.67076514
78	MP0000249_abnormal_blood_vessel	0.66217382
79	MP0002419_abnormal_innate_immunity	0.66175361
80	MP0003941_abnormal_skin_development	0.65598205
81	MP0009763_increased_sensitivity_to	0.64487169
82	MP0000639_abnormal_adrenal_gland	0.63724466
83	MP0008932_abnormal_embryonic_tissue	0.63149146
84	MP0003221_abnormal_cardiomyocyte_apopto	0.63131050
85	MP0002796_impaired_skin_barrier	0.62783776
86	MP0006082_CNS_inflammation	0.62477140
87	MP0005166_decreased_susceptibility_to	0.60213089
88	MP0002006_tumorigenesis	0.59710353
89	MP0000465_gastrointestinal_hemorrhage	0.59219363
90	MP0005319_abnormal_enzyme/_coenzyme	0.59107910
91	MP0005584_abnormal_enzyme/coenzyme_acti	0.57472626
92	MP0000358_abnormal_cell_content/	0.57325159
93	MP0001986_abnormal_taste_sensitivity	0.57226185
94	MP0005023_abnormal_wound_healing	0.56916619
95	MP0001340_abnormal_eyelid_morphology	0.56861577
96	MP0002254_reproductive_system_inflammat	0.56776204
97	MP0001529_abnormal_vocalization	0.56488111
98	MP0003943_abnormal_hepatobiliary_system	0.56409150
99	MP0002822_catalepsy	0.55808648
100	MP0001853_heart_inflammation	0.55774479

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	8.70106535
2	Cholecystitis (HP:0001082)	6.17881926
3	Abnormal gallbladder physiology (HP:0012438)	6.17881926
4	Prolonged partial thromboplastin time (HP:0003645)	5.61777486
5	Hypobetalipoproteinemia (HP:0003563)	4.84325152
6	Type I transferrin isoform profile (HP:0003642)	4.38903325
7	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.29694610
8	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.11469103
9	Generalized aminoaciduria (HP:0002909)	3.95056028
10	Abnormal protein glycosylation (HP:0012346)	3.93480369
11	Abnormal glycosylation (HP:0012345)	3.93480369
12	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.93480369
13	Abnormal protein N-linked glycosylation (HP:0012347)	3.93480369
14	Reduced antithrombin III activity (HP:0001976)	3.82363415
15	Cerebellar dysplasia (HP:0007033)	3.77033240
16	Nonimmune hydrops fetalis (HP:0001790)	3.69478832
17	Abnormality of the common coagulation pathway (HP:0010990)	3.15689071
18	Abnormality of pyrimidine metabolism (HP:0004353)	3.06162232
19	Aplastic anemia (HP:0001915)	2.99363874
20	Azoospermia (HP:0000027)	2.96864048
21	Intrahepatic cholestasis (HP:0001406)	2.93107102
22	Type II lissencephaly (HP:0007260)	2.90691445
23	Spontaneous abortion (HP:0005268)	2.90155074
24	Vacuolated lymphocytes (HP:0001922)	2.79705942
25	Joint hemorrhage (HP:0005261)	2.70215005
26	Menorrhagia (HP:0000132)	2.69320549
27	Hypolipoproteinemia (HP:0010981)	2.69272889
28	Acute hepatic failure (HP:0006554)	2.68857578
29	Long nose (HP:0003189)	2.64912124
30	Elevated alkaline phosphatase (HP:0003155)	2.58961669
31	Malignant hyperthermia (HP:0002047)	2.58226891
32	Hepatocellular necrosis (HP:0001404)	2.55513140
33	Abnormal biliary tract physiology (HP:0012439)	2.53365420
34	Bile duct proliferation (HP:0001408)	2.53365420
35	Abnormal spermatogenesis (HP:0008669)	2.49737922
36	Entropion (HP:0000621)	2.47781954
37	Ulnar claw (HP:0001178)	2.41339669
38	Concave nail (HP:0001598)	2.39339632
39	Increased serum pyruvate (HP:0003542)	2.36067988
40	Hypothermia (HP:0002045)	2.32518893
41	Abnormality of glycolysis (HP:0004366)	2.31341480
42	Abnormality of alkaline phosphatase activity (HP:0004379)	2.28610884
43	Abnormal enzyme/coenzyme activity (HP:0012379)	2.27423286
44	Hyponatremia (HP:0002902)	2.25366386
45	Complement deficiency (HP:0004431)	2.23762210
46	Unilateral renal agenesis (HP:0000122)	2.20607079
47	Delayed CNS myelination (HP:0002188)	2.19999470
48	Abnormality of nucleobase metabolism (HP:0010932)	2.17897823
49	Spastic paraparesis (HP:0002313)	2.14351720
50	Cholelithiasis (HP:0001081)	2.14347883
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11202735
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11202735
53	Conjugated hyperbilirubinemia (HP:0002908)	2.09694859
54	Acute encephalopathy (HP:0006846)	2.07015135
55	Hepatic necrosis (HP:0002605)	2.06533520
56	Polycythemia (HP:0001901)	2.06418845
57	Glomerulonephritis (HP:0000099)	2.05756051
58	IgM deficiency (HP:0002850)	2.03899729
59	Impaired proprioception (HP:0010831)	1.96361807
60	Central scotoma (HP:0000603)	1.95403912
61	Rickets (HP:0002748)	1.95368726
62	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95208293
63	Abnormality of carpal bone ossification (HP:0006257)	1.93993732
64	Increased serum lactate (HP:0002151)	1.93889559
65	Toxemia of pregnancy (HP:0100603)	1.92895384
66	Abnormal gallbladder morphology (HP:0012437)	1.91043382
67	B lymphocytopenia (HP:0010976)	1.89734172
68	Hyperammonemia (HP:0001987)	1.88823711
69	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.88759522
70	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.88227018
71	3-Methylglutaconic aciduria (HP:0003535)	1.86529328
72	Poikiloderma (HP:0001029)	1.82096719
73	Hyperphosphatemia (HP:0002905)	1.79391681
74	Recurrent sinusitis (HP:0011108)	1.78817679
75	Renal Fanconi syndrome (HP:0001994)	1.78302697
76	Widely patent fontanelles and sutures (HP:0004492)	1.77748037
77	Abnormality of purine metabolism (HP:0004352)	1.77443302
78	Abnormality of the vocal cords (HP:0008777)	1.77283071
79	Recurrent gram-negative bacterial infections (HP:0005420)	1.76116137
80	Increased CSF protein (HP:0002922)	1.75574956
81	Abnormality of DNA repair (HP:0003254)	1.75492577
82	Portal hypertension (HP:0001409)	1.74839359
83	J-shaped sella turcica (HP:0002680)	1.74291185
84	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.74069816
85	Emotional lability (HP:0000712)	1.73232133
86	Retinal dysplasia (HP:0007973)	1.73139387
87	Epiphyseal stippling (HP:0010655)	1.72367704
88	Hyperglycinemia (HP:0002154)	1.71981392
89	Abnormality of complement system (HP:0005339)	1.71977763
90	Abnormality of methionine metabolism (HP:0010901)	1.69482690
91	Fatigue (HP:0012378)	1.68843199
92	Alkalosis (HP:0001948)	1.68241015
93	Amelogenesis imperfecta (HP:0000705)	1.67276236
94	Cerebral palsy (HP:0100021)	1.67275475
95	Impaired pain sensation (HP:0007328)	1.66511461
96	Abnormality of pain sensation (HP:0010832)	1.66511461
97	Prolonged bleeding time (HP:0003010)	1.66097820
98	Ectropion (HP:0000656)	1.65386589
99	Peritonitis (HP:0002586)	1.65058885
100	Bifid uvula (HP:0000193)	1.63805534

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.18519005
2	SCYL2	3.98501341
3	MAP3K11	3.87773622
4	MAP4K2	3.75078249
5	PBK	3.74263959
6	MAP3K12	3.55594404
7	KDR	2.95308543
8	TESK2	2.86981649
9	MAP4K1	2.65399828
10	MAP3K13	2.43786474
11	TAOK2	2.24040651
12	MAP3K5	2.11878136
13	MAPK15	2.11649249
14	PIK3CG	2.11609811
15	TBK1	2.09147571
16	NEK1	1.97524221
17	MAP2K3	1.81163611
18	FLT3	1.81090185
19	WNK4	1.78213778
20	PKN2	1.47582983
21	TESK1	1.35441011
22	MAP2K4	1.29192190
23	VRK2	1.28090575
24	BCKDK	1.22802857
25	CAMKK2	1.22453526
26	MAP3K1	1.18097887
27	PRKCI	1.17727622
28	MAP2K7	1.13144289
29	MAP3K3	1.08652521
30	IKBKE	1.05927116
31	CSF1R	0.99295812
32	PIM2	0.97733227
33	STK39	0.95936441
34	BRSK2	0.95884569
35	VRK1	0.95107431
36	CCNB1	0.93559030
37	MST4	0.92414234
38	MARK3	0.91132524
39	ZAP70	0.89222348
40	BLK	0.86189452
41	DAPK1	0.84760410
42	ARAF	0.84397681
43	MAP3K7	0.76928007
44	CSNK1G3	0.75056470
45	BCR	0.69438392
46	CSNK1A1L	0.68294582
47	OXSR1	0.67834008
48	RPS6KA5	0.63684136
49	STK38	0.62863421
50	GRK5	0.61953493
51	MAP3K14	0.61620786
52	MUSK	0.61312750
53	MAP2K2	0.58904414
54	TNK2	0.58071139
55	MST1R	0.55553810
56	CAMKK1	0.53494640
57	ZAK	0.53049846
58	EPHA2	0.52623644
59	KSR1	0.50667327
60	CSNK1G1	0.49588465
61	LIMK1	0.49040997
62	STK38L	0.46652127
63	CSNK1G2	0.45311615
64	LATS1	0.45067489
65	NME2	0.43701576
66	NTRK2	0.42669044
67	LATS2	0.36752754
68	FES	0.34700711
69	DAPK2	0.33179981
70	PRKCQ	0.32516953
71	NUAK1	0.31973763
72	BMPR2	0.31124761
73	MINK1	0.30723560
74	FGR	0.29843487
75	KIT	0.29822546
76	PIM1	0.28280649
77	MAP3K6	0.27871237
78	PAK4	0.27308024
79	ATR	0.26988950
80	MATK	0.26809133
81	CSNK1A1	0.26553453
82	PDK1	0.26476938
83	NEK2	0.23813740
84	PINK1	0.23393462
85	TIE1	0.23281525
86	STK16	0.21332278
87	AKT2	0.21168481
88	PLK1	0.20423584
89	SRPK1	0.19068775
90	ATM	0.17710596
91	MAP2K6	0.17353579
92	LCK	0.16957888
93	AURKA	0.16883512
94	TSSK6	0.15447283
95	PRKCA	0.15220751
96	TGFBR2	0.14869122
97	CSNK2A1	0.14313985
98	MAPK3	0.14267759
99	RET	0.13990485
100	LMTK2	0.13779675

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.70950329
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.44384125
3	Steroid biosynthesis_Homo sapiens_hsa00100	2.77098559
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.46450552
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.44163681
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43848563
7	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.40196165
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.39044958
9	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.28687639
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.24322547
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.21745728
12	Fatty acid elongation_Homo sapiens_hsa00062	2.14752687
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13828138
14	Pyruvate metabolism_Homo sapiens_hsa00620	2.07955280
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.05922841
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.95823071
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.94813083
18	Peroxisome_Homo sapiens_hsa04146	1.94225945
19	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.83110211
20	Retinol metabolism_Homo sapiens_hsa00830	1.72797473
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.69119067
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67614266
23	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.66862304
24	Carbon metabolism_Homo sapiens_hsa01200	1.65488134
25	Propanoate metabolism_Homo sapiens_hsa00640	1.64278571
26	Phototransduction_Homo sapiens_hsa04744	1.63102750
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.62691627
28	Phenylalanine metabolism_Homo sapiens_hsa00360	1.62069034
29	Bile secretion_Homo sapiens_hsa04976	1.60460510
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.59615049
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53574235
32	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.53109024
33	Other glycan degradation_Homo sapiens_hsa00511	1.52856773
34	Sulfur relay system_Homo sapiens_hsa04122	1.46602076
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.44895251
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.40402944
37	Proteasome_Homo sapiens_hsa03050	1.38343394
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32972470
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31865222
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26836195
41	PPAR signaling pathway_Homo sapiens_hsa03320	1.17444558
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14430390
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13509108
44	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.11727987
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08060265
46	One carbon pool by folate_Homo sapiens_hsa00670	1.04375442
47	Fatty acid degradation_Homo sapiens_hsa00071	1.02682373
48	Mineral absorption_Homo sapiens_hsa04978	1.01892698
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01696866
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95569672
51	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95279044
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.94645055
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.94443523
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.88797221
55	Pentose phosphate pathway_Homo sapiens_hsa00030	0.88529802
56	Butanoate metabolism_Homo sapiens_hsa00650	0.88291070
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86234231
58	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.79523450
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.79171223
60	Metabolic pathways_Homo sapiens_hsa01100	0.78896352
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.78683119
62	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.77696321
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.73989470
64	Regulation of autophagy_Homo sapiens_hsa04140	0.73529586
65	Parkinsons disease_Homo sapiens_hsa05012	0.72353320
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70047770
67	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.69578394
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67969593
69	Folate biosynthesis_Homo sapiens_hsa00790	0.64716206
70	Galactose metabolism_Homo sapiens_hsa00052	0.62947810
71	Primary immunodeficiency_Homo sapiens_hsa05340	0.62170827
72	Sulfur metabolism_Homo sapiens_hsa00920	0.61926553
73	ABC transporters_Homo sapiens_hsa02010	0.61921515
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.60706885
75	Histidine metabolism_Homo sapiens_hsa00340	0.57918271
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.53355587
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.52870051
78	Glutathione metabolism_Homo sapiens_hsa00480	0.48059745
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45143492
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41628973
81	Herpes simplex infection_Homo sapiens_hsa05168	0.40475356
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38194643
83	Huntingtons disease_Homo sapiens_hsa05016	0.36268360
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36263501
85	Pertussis_Homo sapiens_hsa05133	0.35667257
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.35266678
87	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32954498
88	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.31111795
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.30991256
90	Lysosome_Homo sapiens_hsa04142	0.29839610
91	Oxidative phosphorylation_Homo sapiens_hsa00190	0.29455564
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.28105470
93	Basal transcription factors_Homo sapiens_hsa03022	0.27765058
94	Circadian rhythm_Homo sapiens_hsa04710	0.27270631
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24054496
96	Lysine degradation_Homo sapiens_hsa00310	0.24004923
97	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23965747
98	Base excision repair_Homo sapiens_hsa03410	0.23716072
99	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.21740325
100	RNA transport_Homo sapiens_hsa03013	0.19598941

KLHL2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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