KLHL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.04886687
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.77512590
3vocalization behavior (GO:0071625)5.52949466
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.49191018
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.39530666
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28871955
7protein localization to synapse (GO:0035418)5.15673514
8locomotory exploration behavior (GO:0035641)5.06282572
9synaptic vesicle exocytosis (GO:0016079)5.04883800
10neurotransmitter-gated ion channel clustering (GO:0072578)5.04558497
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.03260679
12glutamate receptor signaling pathway (GO:0007215)5.01938956
13synaptic transmission, glutamatergic (GO:0035249)5.00510604
14regulation of glutamate receptor signaling pathway (GO:1900449)4.99574732
15synaptic vesicle maturation (GO:0016188)4.88272799
16glutamate secretion (GO:0014047)4.79210479
17regulation of synaptic vesicle exocytosis (GO:2000300)4.53555344
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.51855457
19neuron-neuron synaptic transmission (GO:0007270)4.49129430
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.49011944
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.43864518
22regulation of synaptic vesicle transport (GO:1902803)4.36538743
23long-term memory (GO:0007616)4.30481400
24regulation of neuronal synaptic plasticity (GO:0048168)4.29085158
25regulation of type B pancreatic cell apoptotic process (GO:2000674)4.25563169
26regulation of excitatory postsynaptic membrane potential (GO:0060079)4.24959857
27positive regulation of membrane potential (GO:0045838)4.23023544
28exploration behavior (GO:0035640)4.20173363
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.07547120
30regulation of synapse structural plasticity (GO:0051823)4.05851344
31cellular sodium ion homeostasis (GO:0006883)4.05351063
32positive regulation of synapse maturation (GO:0090129)4.03518013
33detection of calcium ion (GO:0005513)4.02912091
34regulation of postsynaptic membrane potential (GO:0060078)3.98372320
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.97100362
36neurotransmitter secretion (GO:0007269)3.91414732
37neuronal action potential propagation (GO:0019227)3.86315148
38regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.84723310
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.80009256
40neuron cell-cell adhesion (GO:0007158)3.78275633
41regulation of synapse maturation (GO:0090128)3.76932487
42positive regulation of neurotransmitter secretion (GO:0001956)3.69901841
43behavioral fear response (GO:0001662)3.63936655
44behavioral defense response (GO:0002209)3.63936655
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.60862337
46synaptic vesicle endocytosis (GO:0048488)3.60630181
47dendritic spine morphogenesis (GO:0060997)3.59835334
48regulation of synaptic plasticity (GO:0048167)3.58726713
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57305787
50long-term synaptic potentiation (GO:0060291)3.56802016
51positive regulation of dendritic spine morphogenesis (GO:0061003)3.52324989
52regulation of dendritic spine morphogenesis (GO:0061001)3.51128790
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50218139
54cellular potassium ion homeostasis (GO:0030007)3.47687337
55regulation of neurotransmitter secretion (GO:0046928)3.45295865
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.42207349
57gamma-aminobutyric acid transport (GO:0015812)3.42096296
58membrane depolarization during action potential (GO:0086010)3.40030777
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.39961187
60proline transport (GO:0015824)3.39272508
61positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.37628505
62membrane depolarization (GO:0051899)3.33576262
63positive regulation of neurotransmitter transport (GO:0051590)3.32491404
64brain morphogenesis (GO:0048854)3.31993488
65presynaptic membrane assembly (GO:0097105)3.30471899
66response to histamine (GO:0034776)3.29072429
67neurotransmitter transport (GO:0006836)3.27318210
68presynaptic membrane organization (GO:0097090)3.26691495
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.25225779
70positive regulation of dendritic spine development (GO:0060999)3.25096388
71cell communication involved in cardiac conduction (GO:0086065)3.24886797
72cell communication by electrical coupling (GO:0010644)3.23450920
73negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21914391
74fear response (GO:0042596)3.20084352
75regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.19292338
76innervation (GO:0060384)3.18195893
77transmission of nerve impulse (GO:0019226)3.18083546
78learning (GO:0007612)3.16349769
79dendritic spine organization (GO:0097061)3.15796828
80regulation of neurotransmitter transport (GO:0051588)3.13504273
81regulation of vesicle fusion (GO:0031338)3.13336894
82response to pheromone (GO:0019236)3.13281149
83calcium ion-dependent exocytosis (GO:0017156)3.12366800
84neuron recognition (GO:0008038)3.11439816
85postsynaptic membrane organization (GO:0001941)3.11062017
86striatum development (GO:0021756)3.09248471
87auditory behavior (GO:0031223)3.05585525
88membrane hyperpolarization (GO:0060081)3.05580005
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.05103545
90response to auditory stimulus (GO:0010996)3.04607756
91cellular ketone body metabolic process (GO:0046950)3.04185345
92cerebellar Purkinje cell differentiation (GO:0021702)3.03580983
93synaptic transmission (GO:0007268)3.02910146
94regulation of cell communication by electrical coupling (GO:0010649)2.99313090
95long term synaptic depression (GO:0060292)2.99197549
96regulation of membrane repolarization (GO:0060306)2.98379230
97regulation of dendritic spine development (GO:0060998)2.97020365
98negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95681526
99neuronal action potential (GO:0019228)2.95523126
100cyclic nucleotide catabolic process (GO:0009214)2.94500971
101startle response (GO:0001964)2.94181036
102cardiac conduction (GO:0061337)2.94092673
103positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.93227641
104regulation of synaptic transmission (GO:0050804)2.91958851
105positive regulation of synaptic transmission (GO:0050806)2.91952964
106cardiac muscle cell action potential (GO:0086001)2.91183240
107sodium ion export (GO:0071436)2.91175680
108positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91082116
109potassium ion import (GO:0010107)2.90646734
110central nervous system projection neuron axonogenesis (GO:0021952)2.87920231
111regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87613941
112regulation of neurotransmitter levels (GO:0001505)2.87209707
113atrial cardiac muscle cell action potential (GO:0086014)2.86867085
114establishment of protein localization to Golgi (GO:0072600)2.86242019
115cardiac muscle cell action potential involved in contraction (GO:0086002)2.85676346
116cAMP catabolic process (GO:0006198)2.83663327
117action potential (GO:0001508)2.83229363
118synapse assembly (GO:0007416)2.82443431
119chemosensory behavior (GO:0007635)2.82335277
120neuromuscular process controlling balance (GO:0050885)2.81956258
121negative regulation of cAMP-mediated signaling (GO:0043951)2.80634616
122regulation of voltage-gated calcium channel activity (GO:1901385)2.79512717
123regulation of female receptivity (GO:0045924)2.79000540
124regulation of heart rate by cardiac conduction (GO:0086091)2.78999689
125mechanosensory behavior (GO:0007638)2.78342109
126positive regulation of CREB transcription factor activity (GO:0032793)2.78006867
127adult heart development (GO:0007512)2.76798614
128acrosome reaction (GO:0007340)2.76171205
129protein targeting to Golgi (GO:0000042)2.74429724
130regulation of sodium ion transmembrane transporter activity (GO:2000649)2.73388668
131multicellular organismal signaling (GO:0035637)2.72103039
132cochlea development (GO:0090102)2.72000587
133relaxation of cardiac muscle (GO:0055119)2.71360376
134insulin secretion (GO:0030073)2.71002715
135ketone body metabolic process (GO:1902224)2.69247471
136central nervous system myelination (GO:0022010)2.68145291
137axon ensheathment in central nervous system (GO:0032291)2.68145291
138C4-dicarboxylate transport (GO:0015740)2.66310074
139positive regulation of potassium ion transmembrane transport (GO:1901381)2.65214708
140regulation of calcium ion-dependent exocytosis (GO:0017158)2.64030513
141sodium ion homeostasis (GO:0055078)2.63523272
142phosphorelay signal transduction system (GO:0000160)2.59158532
143regulation of sodium ion transmembrane transport (GO:1902305)2.58551246
144retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56779901
145positive regulation of action potential (GO:0045760)2.56188247
146negative regulation of hormone biosynthetic process (GO:0032353)2.55372075
147positive regulation of sodium ion transport (GO:0010765)2.54321392
148potassium ion transmembrane transport (GO:0071805)2.54036880
149cellular potassium ion transport (GO:0071804)2.54036880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47907030
2GBX2_23144817_ChIP-Seq_PC3_Human4.45934642
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91532377
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86272029
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82739431
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.63678417
7DROSHA_22980978_ChIP-Seq_HELA_Human2.61749505
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45581578
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44879766
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43104171
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43104171
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40085085
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30338985
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28703345
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28281485
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27287751
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.26944840
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25485948
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.24449061
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16312480
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.16144583
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13219550
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13124667
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.10739204
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08718796
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07178172
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05203442
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.02282999
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99018406
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89321424
31SMAD4_21799915_ChIP-Seq_A2780_Human1.78975901
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.78297366
33TAF15_26573619_Chip-Seq_HEK293_Human1.77784108
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77394309
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71497677
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71352901
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64359917
38AR_21572438_ChIP-Seq_LNCaP_Human1.61005659
39P300_19829295_ChIP-Seq_ESCs_Human1.58277728
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56946970
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52837708
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52785167
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52178919
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.50073056
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49246619
46IGF1R_20145208_ChIP-Seq_DFB_Human1.47638415
47BCAT_22108803_ChIP-Seq_LS180_Human1.44950352
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42004880
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41558428
50AR_25329375_ChIP-Seq_VCAP_Human1.36472040
51STAT3_23295773_ChIP-Seq_U87_Human1.36036440
52* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32979984
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31325728
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.30312818
55* TCF4_23295773_ChIP-Seq_U87_Human1.28858223
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28724335
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28618223
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.27647438
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26946473
60AR_19668381_ChIP-Seq_PC3_Human1.24729269
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24224037
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22825522
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.22133210
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.20073986
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19382346
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19225992
67P53_22387025_ChIP-Seq_ESCs_Mouse1.19035508
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16052569
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15889693
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.14582480
71TCF4_22108803_ChIP-Seq_LS180_Human1.14397784
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14109086
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.13158696
74SOX2_19829295_ChIP-Seq_ESCs_Human1.13102417
75NANOG_19829295_ChIP-Seq_ESCs_Human1.13102417
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.12856780
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11914251
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.11363759
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.11274531
80* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09114874
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.09025263
82EWS_26573619_Chip-Seq_HEK293_Human1.08758092
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07289633
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07229090
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07115108
86RNF2_27304074_Chip-Seq_NSC_Mouse1.07036870
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.06626273
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.06235507
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06169849
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06116430
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05548543
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04711907
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04711907
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04214082
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03526091
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03432477
97SMAD3_21741376_ChIP-Seq_ESCs_Human1.03090176
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02961726
99ZNF274_21170338_ChIP-Seq_K562_Hela1.02764642
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02595803
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.02418093
102FUS_26573619_Chip-Seq_HEK293_Human1.02324547
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01376959
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00674758
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00635556
106RUNX2_22187159_ChIP-Seq_PCA_Human1.00426592
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00106800
108* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99520915
109ER_23166858_ChIP-Seq_MCF-7_Human0.99464427
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97033220
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.96947344
112KDM2B_26808549_Chip-Seq_REH_Human0.96858572
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96708013
114CBP_20019798_ChIP-Seq_JUKART_Human0.96708013
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.95431772
116VDR_22108803_ChIP-Seq_LS180_Human0.95247202
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94595409
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.92982252
119JUN_21703547_ChIP-Seq_K562_Human0.92883272
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91678436
121TP53_16413492_ChIP-PET_HCT116_Human0.90948863
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90517569
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89333408
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87628732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.01645469
2MP0003880_abnormal_central_pattern4.73297641
3MP0003635_abnormal_synaptic_transmissio4.14901407
4MP0009745_abnormal_behavioral_response3.61025804
5MP0002063_abnormal_learning/memory/cond3.38849612
6MP0004270_analgesia3.24778716
7MP0008877_abnormal_DNA_methylation3.19850382
8MP0002822_catalepsy3.18510572
9MP0002064_seizures3.15329062
10MP0009046_muscle_twitch3.07923966
11MP0002572_abnormal_emotion/affect_behav2.85717394
12MP0002837_dystrophic_cardiac_calcinosis2.78859179
13MP0001486_abnormal_startle_reflex2.77893639
14MP0001968_abnormal_touch/_nociception2.68566845
15MP0005423_abnormal_somatic_nervous2.57296568
16MP0002272_abnormal_nervous_system2.53804368
17MP0002735_abnormal_chemical_nociception2.33089632
18MP0001501_abnormal_sleep_pattern2.25393101
19MP0002734_abnormal_mechanical_nocicepti2.25079547
20MP0006072_abnormal_retinal_apoptosis2.14039455
21MP0002736_abnormal_nociception_after2.11406533
22MP0003879_abnormal_hair_cell2.11179080
23MP0005551_abnormal_eye_electrophysiolog1.93311790
24MP0002067_abnormal_sensory_capabilities1.91537185
25MP0001984_abnormal_olfaction1.88821340
26MP0005646_abnormal_pituitary_gland1.86555589
27MP0001440_abnormal_grooming_behavior1.79531492
28MP0008569_lethality_at_weaning1.77822861
29MP0004924_abnormal_behavior1.66162441
30MP0005386_behavior/neurological_phenoty1.66162441
31MP0002557_abnormal_social/conspecific_i1.65042396
32MP0001188_hyperpigmentation1.63840430
33MP0002184_abnormal_innervation1.57694054
34MP0004811_abnormal_neuron_physiology1.54461721
35MP0003787_abnormal_imprinting1.53535915
36MP0001970_abnormal_pain_threshold1.50430683
37MP0001485_abnormal_pinna_reflex1.48530657
38MP0000778_abnormal_nervous_system1.48007125
39MP0002733_abnormal_thermal_nociception1.46330590
40MP0001502_abnormal_circadian_rhythm1.44789583
41MP0009780_abnormal_chondrocyte_physiolo1.41473897
42MP0000569_abnormal_digit_pigmentation1.38741352
43MP0002876_abnormal_thyroid_physiology1.38663551
44MP0003633_abnormal_nervous_system1.34684483
45MP0006292_abnormal_olfactory_placode1.33808843
46MP0003195_calcinosis1.33784966
47MP0000955_abnormal_spinal_cord1.31534438
48MP0003329_amyloid_beta_deposits1.31094338
49MP0002066_abnormal_motor_capabilities/c1.29809508
50MP0003121_genomic_imprinting1.28430082
51MP0002909_abnormal_adrenal_gland1.28120199
52MP0010386_abnormal_urinary_bladder1.22825859
53MP0002882_abnormal_neuron_morphology1.21800272
54MP0004858_abnormal_nervous_system1.20668772
55MP0004142_abnormal_muscle_tone1.20379093
56MP0004084_abnormal_cardiac_muscle1.19083169
57MP0005670_abnormal_white_adipose1.16146309
58MP0005410_abnormal_fertilization1.14534822
59MP0001299_abnormal_eye_distance/1.14186072
60MP0003283_abnormal_digestive_organ1.13591043
61MP0008775_abnormal_heart_ventricle1.12239959
62MP0005075_abnormal_melanosome_morpholog1.10660217
63MP0008874_decreased_physiological_sensi1.10353076
64MP0004885_abnormal_endolymph1.10241328
65MP0001529_abnormal_vocalization1.10066540
66MP0003631_nervous_system_phenotype1.09640126
67MP0002102_abnormal_ear_morphology1.07895620
68MP0002069_abnormal_eating/drinking_beha1.07425081
69MP0004510_myositis1.05623549
70MP0001905_abnormal_dopamine_level1.05403675
71MP0006276_abnormal_autonomic_nervous1.04301346
72MP0005379_endocrine/exocrine_gland_phen1.04092264
73MP0002229_neurodegeneration1.03456634
74MP0008872_abnormal_physiological_respon1.02142598
75MP0002090_abnormal_vision1.01339106
76MP0005535_abnormal_body_temperature1.01309894
77MP0003690_abnormal_glial_cell0.98937439
78MP0005645_abnormal_hypothalamus_physiol0.98450756
79MP0002638_abnormal_pupillary_reflex0.97806044
80MP0001944_abnormal_pancreas_morphology0.93960257
81MP0005085_abnormal_gallbladder_physiolo0.92349515
82MP0002693_abnormal_pancreas_physiology0.90562293
83MP0004036_abnormal_muscle_relaxation0.90547456
84MP0001765_abnormal_ion_homeostasis0.90329106
85MP0005377_hearing/vestibular/ear_phenot0.89583477
86MP0003878_abnormal_ear_physiology0.89583477
87MP0008961_abnormal_basal_metabolism0.89362237
88MP0003075_altered_response_to0.87464296
89MP0003646_muscle_fatigue0.87257757
90MP0004043_abnormal_pH_regulation0.86689587
91MP0002152_abnormal_brain_morphology0.86519429
92MP0004147_increased_porphyrin_level0.86450369
93MP0004215_abnormal_myocardial_fiber0.85972994
94MP0005360_urolithiasis0.84873375
95MP0004085_abnormal_heartbeat0.83209651
96MP0004130_abnormal_muscle_cell0.82546656
97MP0004145_abnormal_muscle_electrophysio0.81482903
98MP0001963_abnormal_hearing_physiology0.80794026
99MP0000230_abnormal_systemic_arterial0.78696969
100MP0004133_heterotaxia0.78568281
101MP0003123_paternal_imprinting0.78490592
102MP0000013_abnormal_adipose_tissue0.76300050
103MP0003137_abnormal_impulse_conducting0.74740470
104MP0009697_abnormal_copulation0.74160005
105MP0000427_abnormal_hair_cycle0.73305207
106MP0010329_abnormal_lipoprotein_level0.73088655
107MP0001177_atelectasis0.72664937
108MP0005620_abnormal_muscle_contractility0.72167002
109MP0002752_abnormal_somatic_nervous0.69741295
110MP0003632_abnormal_nervous_system0.69692669
111MP0005394_taste/olfaction_phenotype0.69592990
112MP0005499_abnormal_olfactory_system0.69592990
113MP0001986_abnormal_taste_sensitivity0.69375261
114MP0004742_abnormal_vestibular_system0.68419380
115MP0005310_abnormal_salivary_gland0.64815074
116MP0000604_amyloidosis0.64731186
117MP0005365_abnormal_bile_salt0.64408235
118MP0005253_abnormal_eye_physiology0.64009009
119MP0004019_abnormal_vitamin_homeostasis0.62582829
120MP0005332_abnormal_amino_acid0.62069301
121MP0003172_abnormal_lysosome_physiology0.61626161
122MP0000015_abnormal_ear_pigmentation0.59359039
123MP0005409_darkened_coat_color0.57515119
124MP0004484_altered_response_of0.55451024
125MP0001664_abnormal_digestion0.54661368
126MP0005171_absent_coat_pigmentation0.53890711
127MP0005195_abnormal_posterior_eye0.53698922
128MP0000631_abnormal_neuroendocrine_gland0.52030453
129MP0003122_maternal_imprinting0.50550933
130MP0005167_abnormal_blood-brain_barrier0.50453131

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.91420507
2Myokymia (HP:0002411)6.11615150
3Epileptic encephalopathy (HP:0200134)5.42621056
4Febrile seizures (HP:0002373)5.42160908
5Focal seizures (HP:0007359)5.38736024
6Progressive cerebellar ataxia (HP:0002073)4.39767348
7Visual hallucinations (HP:0002367)4.38714538
8Hyperventilation (HP:0002883)3.86023740
9Atonic seizures (HP:0010819)3.78390294
10Absence seizures (HP:0002121)3.76503379
11Gaze-evoked nystagmus (HP:0000640)3.66359366
12Generalized tonic-clonic seizures (HP:0002069)3.64643662
13Broad-based gait (HP:0002136)3.62354180
14Congenital stationary night blindness (HP:0007642)3.58176965
15Dialeptic seizures (HP:0011146)3.52311688
16Bundle branch block (HP:0011710)3.45178665
17Nuclear cataract (HP:0100018)3.38511455
18Poor eye contact (HP:0000817)3.34450658
19Action tremor (HP:0002345)3.16379048
20Severe visual impairment (HP:0001141)3.14912925
21Dysdiadochokinesis (HP:0002075)3.10754379
22Postural instability (HP:0002172)3.00255463
23Impaired smooth pursuit (HP:0007772)2.97576745
24Atrial fibrillation (HP:0005110)2.89135385
25Double outlet right ventricle (HP:0001719)2.88908217
26Congenital malformation of the right heart (HP:0011723)2.88908217
27Depression (HP:0000716)2.87502568
28Impaired vibration sensation in the lower limbs (HP:0002166)2.87216835
29Impaired social interactions (HP:0000735)2.85731645
30Abnormal social behavior (HP:0012433)2.85731645
31Scanning speech (HP:0002168)2.84386785
32Fair hair (HP:0002286)2.84224004
33Dysmetria (HP:0001310)2.79167410
34Truncal ataxia (HP:0002078)2.73646815
35Abnormal eating behavior (HP:0100738)2.73498033
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.72521148
37Absent/shortened dynein arms (HP:0200106)2.72521148
38Central scotoma (HP:0000603)2.71181661
39Epileptiform EEG discharges (HP:0011182)2.69764545
40Ventricular fibrillation (HP:0001663)2.69605108
41Primary atrial arrhythmia (HP:0001692)2.69447451
42Genetic anticipation (HP:0003743)2.68293370
43Abnormality of the lower motor neuron (HP:0002366)2.67570071
44Anxiety (HP:0000739)2.67118677
45Status epilepticus (HP:0002133)2.67089646
46* Hyperkalemia (HP:0002153)2.66626994
47Thyroiditis (HP:0100646)2.63910646
48Drooling (HP:0002307)2.62594700
49Excessive salivation (HP:0003781)2.62594700
50Protruding tongue (HP:0010808)2.61636186
51Urinary bladder sphincter dysfunction (HP:0002839)2.59710879
52Dysmetric saccades (HP:0000641)2.57416211
53Sudden death (HP:0001699)2.55697396
54Increased circulating renin level (HP:0000848)2.54687676
55Intestinal atresia (HP:0011100)2.53602552
56Abnormality of ocular smooth pursuit (HP:0000617)2.53507859
57Fetal akinesia sequence (HP:0001989)2.51425731
58Generalized hypopigmentation of hair (HP:0011358)2.50808263
59Limb dystonia (HP:0002451)2.50171634
60Torticollis (HP:0000473)2.50094133
61Supraventricular tachycardia (HP:0004755)2.49730456
62Focal dystonia (HP:0004373)2.48315709
63Bradykinesia (HP:0002067)2.48172733
64Hyperactive renin-angiotensin system (HP:0000841)2.44828294
65Hemiparesis (HP:0001269)2.44341471
66Supraventricular arrhythmia (HP:0005115)2.43341732
67Gait imbalance (HP:0002141)2.43076029
68EEG with generalized epileptiform discharges (HP:0011198)2.41446644
69Heart block (HP:0012722)2.40748234
70Pancreatic fibrosis (HP:0100732)2.40218980
71Stereotypic behavior (HP:0000733)2.39350371
72Mutism (HP:0002300)2.37883300
73Supranuclear gaze palsy (HP:0000605)2.37844834
74Aqueductal stenosis (HP:0002410)2.36874806
75Hematochezia (HP:0002573)2.36117694
76Blue irides (HP:0000635)2.35281710
77Impaired vibratory sensation (HP:0002495)2.34466187
78Colon cancer (HP:0003003)2.33423538
79Absent speech (HP:0001344)2.32457166
80Decreased circulating renin level (HP:0003351)2.28840831
81Attenuation of retinal blood vessels (HP:0007843)2.28015556
82Palpitations (HP:0001962)2.27222757
83Diplopia (HP:0000651)2.26454629
84Abnormality of binocular vision (HP:0011514)2.26454629
85Abnormality of the labia minora (HP:0012880)2.23719286
86Abnormal drinking behavior (HP:0030082)2.22860944
87Polydipsia (HP:0001959)2.22860944
88Hemiplegia (HP:0002301)2.19619016
89Amblyopia (HP:0000646)2.18689972
90Hypsarrhythmia (HP:0002521)2.18559626
91Abnormality of macular pigmentation (HP:0008002)2.17119236
92Inability to walk (HP:0002540)2.16952266
93Decreased central vision (HP:0007663)2.16775812
94Toxemia of pregnancy (HP:0100603)2.16452714
95Nephronophthisis (HP:0000090)2.14918765
96Ankle clonus (HP:0011448)2.13093970
97Congenital primary aphakia (HP:0007707)2.11532592
98Medial flaring of the eyebrow (HP:0010747)2.10578959
99Hypomagnesemia (HP:0002917)2.10263181
100Nephrogenic diabetes insipidus (HP:0009806)2.09620655
101Craniofacial dystonia (HP:0012179)2.09361058
102Ketoacidosis (HP:0001993)2.05787077
103* Abnormality of potassium homeostasis (HP:0011042)2.05444891
104Polyphagia (HP:0002591)2.04851438
105Intention tremor (HP:0002080)2.04570535
106True hermaphroditism (HP:0010459)2.02479068
107Abnormal EKG (HP:0003115)1.98693822
108Incomplete penetrance (HP:0003829)1.97956456
109Pancreatic cysts (HP:0001737)1.97171262
110Metabolic alkalosis (HP:0200114)1.96493425
111Abolished electroretinogram (ERG) (HP:0000550)1.95869656
112Metaphyseal dysplasia (HP:0100255)1.95333730
113Agitation (HP:0000713)1.95080274
114Abnormal atrioventricular conduction (HP:0005150)1.94500535
115Papilledema (HP:0001085)1.91545981
116Abnormality of vitamin B metabolism (HP:0004340)1.91075418
117Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90996925
118Abnormality of alanine metabolism (HP:0010916)1.90996925
119Hyperalaninemia (HP:0003348)1.90996925
120Abnormal ciliary motility (HP:0012262)1.90913663
121Severe combined immunodeficiency (HP:0004430)1.90303608
122Hypothermia (HP:0002045)1.88330221
123Ventricular arrhythmia (HP:0004308)1.86910864
124Abnormality of renin-angiotensin system (HP:0000847)1.86163389
125Spinal canal stenosis (HP:0003416)1.86026454
126Testicular atrophy (HP:0000029)1.84837434
127Hyperaldosteronism (HP:0000859)1.82328518
128Abnormal rod and cone electroretinograms (HP:0008323)1.82096404
129Limb ataxia (HP:0002070)1.81041556
130Palpebral edema (HP:0100540)1.80500935
131Poor coordination (HP:0002370)1.80284915
132Unsteady gait (HP:0002317)1.80089519
133Abnormality of saccadic eye movements (HP:0000570)1.78476384
134Spastic gait (HP:0002064)1.78035889
135Atrioventricular block (HP:0001678)1.77641846
136Psychosis (HP:0000709)1.77358135
137Tubulointerstitial nephritis (HP:0001970)1.77235006
138Methylmalonic acidemia (HP:0002912)1.76386643
139Abnormality of the renal medulla (HP:0100957)1.76017517
140Oligodactyly (hands) (HP:0001180)1.75359629
141Optic nerve hypoplasia (HP:0000609)1.74205329
142Abnormality of the renal cortex (HP:0011035)1.70067345
143Glucose intolerance (HP:0000833)1.69472054
144Chronic hepatic failure (HP:0100626)1.68693482
145Spastic tetraparesis (HP:0001285)1.66158120
146Abnormality of salivation (HP:0100755)1.65852588
147Syncope (HP:0001279)1.65448383
148Abnormality of the periventricular white matter (HP:0002518)1.65189020
149Prolonged QT interval (HP:0001657)1.65144866
150Retinal atrophy (HP:0001105)1.64613978
151Generalized myoclonic seizures (HP:0002123)1.64264119

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.17653207
2EPHA44.88970896
3NTRK34.56470466
4MAP2K73.20685325
5MARK13.06651172
6PRPF4B2.94400630
7RIPK42.87714304
8MAP3K42.83736131
9FGFR22.68655483
10DAPK22.50087319
11MAP3K92.45646425
12TIE12.31477499
13TNIK2.29499587
14SIK32.24187092
15MINK12.22139664
16CASK2.09990340
17DAPK11.98446298
18NTRK21.94457300
19NLK1.92638119
20PAK61.92248875
21CAMKK11.88762337
22EEF2K1.82488675
23SIK21.81344585
24MAP2K41.71712051
25KSR11.67920734
26STK381.67198020
27FES1.55475774
28SGK21.49287799
29MAP3K121.49062479
30CAMKK21.42211682
31CDK51.41726552
32BMPR21.40889553
33MAPKAPK31.40622010
34PLK21.36609217
35MAP3K131.35370407
36PRKD31.30947914
37CAMK11.30302517
38TAOK21.29947847
39MAP4K21.28445007
40TRPM71.26968004
41PRKCG1.26659851
42MAPK131.21790894
43PTK2B1.18904705
44SGK2231.18304003
45SGK4941.18304003
46TAOK31.18250836
47PINK11.16401325
48GRK51.13181789
49OBSCN1.10880167
50ITK1.06027104
51SGK31.02519949
52MKNK21.01328589
53WNK11.00562339
54KSR21.00329934
55NTRK10.99505281
56CAMK2A0.98354323
57TEC0.95977244
58NUAK10.95902460
59BMPR1B0.94537918
60OXSR10.90421292
61MAPKAPK50.85373993
62RAF10.85362432
63ARAF0.85231985
64INSRR0.84090169
65PDK20.83895158
66CAMK2B0.82600105
67SGK10.82593265
68CAMK40.80497338
69MAP3K70.80290891
70NEK60.78511647
71DYRK1A0.72226641
72AKT30.70005231
73STK38L0.69560240
74WNK30.69294841
75PRKCH0.69225758
76GRK10.69107017
77TXK0.68331199
78PDK10.67634537
79TNK20.65521181
80PLK40.64696257
81MARK20.61362968
82CDK190.57527477
83FGFR30.55729043
84CDK180.55465171
85STK110.55031910
86PRKCZ0.53340285
87STK390.53236491
88DMPK0.53000611
89PRKCE0.52085216
90PIK3CG0.50185637
91PNCK0.49804218
92PDPK10.49090556
93BRD40.48478285
94CDK150.48049920
95WNK40.47820360
96TAOK10.47133304
97MAPK70.46656486
98PRKAA20.46400350
99PHKG10.45776532
100PHKG20.45776532
101RPS6KA30.45519978
102MUSK0.45338728
103CCNB10.45234902
104PKN10.45061610
105PRKAA10.44763967
106MAPK120.43342164
107PRKACB0.42227444
108CDK11A0.40732927
109YES10.40592331
110PIK3CA0.39835077
111FYN0.39438448
112ACVR1B0.39005604
113UHMK10.37519698
114PRKG10.37414607
115MAP2K60.37354480
116MAP3K10.37159707
117ROCK20.37016109
118CDK30.36930372
119ALK0.36768226
120CSNK1G20.36747005
121CAMK2D0.36257814
122ADRBK20.35189027
123CAMK2G0.35046206
124MAPK100.34931304
125CSNK1G10.34777817
126PRKCB0.34575854
127PAK30.34396876
128PRKCA0.34141789
129CDK140.32048590
130CDC42BPA0.31848293
131CAMK1G0.31658260
132PRKACA0.29927666
133RET0.29064219
134BRSK10.28403020
135FGR0.28295459
136MAP3K60.27834515

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74776310
2Circadian entrainment_Homo sapiens_hsa047133.11867878
3Synaptic vesicle cycle_Homo sapiens_hsa047213.09362054
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.04752819
5Morphine addiction_Homo sapiens_hsa050322.91757516
6GABAergic synapse_Homo sapiens_hsa047272.89954630
7Glutamatergic synapse_Homo sapiens_hsa047242.89752942
8Olfactory transduction_Homo sapiens_hsa047402.83343890
9Long-term potentiation_Homo sapiens_hsa047202.64407178
10Amphetamine addiction_Homo sapiens_hsa050312.45716754
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.32393557
12Salivary secretion_Homo sapiens_hsa049702.23286229
13Insulin secretion_Homo sapiens_hsa049112.06912642
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.05400529
15Dopaminergic synapse_Homo sapiens_hsa047281.97477464
16Taste transduction_Homo sapiens_hsa047421.92979208
17Calcium signaling pathway_Homo sapiens_hsa040201.90060689
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88391611
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84776021
20Cholinergic synapse_Homo sapiens_hsa047251.82601316
21Phototransduction_Homo sapiens_hsa047441.82450109
22Renin secretion_Homo sapiens_hsa049241.69460894
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64429001
24Serotonergic synapse_Homo sapiens_hsa047261.62156584
25Gastric acid secretion_Homo sapiens_hsa049711.61963276
26Long-term depression_Homo sapiens_hsa047301.47663766
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39122418
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36346134
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35510468
30cAMP signaling pathway_Homo sapiens_hsa040241.35305298
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33890566
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32059162
33Cocaine addiction_Homo sapiens_hsa050301.30117854
34Type II diabetes mellitus_Homo sapiens_hsa049301.24608757
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24458790
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17070994
37Propanoate metabolism_Homo sapiens_hsa006401.16858402
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10047713
39Collecting duct acid secretion_Homo sapiens_hsa049661.08092288
40GnRH signaling pathway_Homo sapiens_hsa049121.06394237
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04904733
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03171967
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99137553
44Selenocompound metabolism_Homo sapiens_hsa004500.95015753
45Dorso-ventral axis formation_Homo sapiens_hsa043200.93782424
46Ether lipid metabolism_Homo sapiens_hsa005650.91486170
47Linoleic acid metabolism_Homo sapiens_hsa005910.90189198
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87780213
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86028499
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.83153667
51Gap junction_Homo sapiens_hsa045400.82243448
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.82169805
53Axon guidance_Homo sapiens_hsa043600.80438798
54Arginine biosynthesis_Homo sapiens_hsa002200.79633082
55ErbB signaling pathway_Homo sapiens_hsa040120.79221410
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76408414
57Bile secretion_Homo sapiens_hsa049760.75568437
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75234007
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74735921
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73041659
61Tryptophan metabolism_Homo sapiens_hsa003800.71177488
62Nitrogen metabolism_Homo sapiens_hsa009100.70481731
63Glioma_Homo sapiens_hsa052140.70016867
64Circadian rhythm_Homo sapiens_hsa047100.69807924
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.67092299
66Pancreatic secretion_Homo sapiens_hsa049720.65768932
67Estrogen signaling pathway_Homo sapiens_hsa049150.64923507
68African trypanosomiasis_Homo sapiens_hsa051430.64017012
69Choline metabolism in cancer_Homo sapiens_hsa052310.63977357
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63197546
71Cardiac muscle contraction_Homo sapiens_hsa042600.60756153
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59690961
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59437047
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58172852
75MAPK signaling pathway_Homo sapiens_hsa040100.57423876
76Glucagon signaling pathway_Homo sapiens_hsa049220.57309972
77Melanogenesis_Homo sapiens_hsa049160.53784305
78Type I diabetes mellitus_Homo sapiens_hsa049400.53327964
79Vitamin digestion and absorption_Homo sapiens_hsa049770.53285897
80Thyroid hormone synthesis_Homo sapiens_hsa049180.52900439
81beta-Alanine metabolism_Homo sapiens_hsa004100.52696055
82Dilated cardiomyopathy_Homo sapiens_hsa054140.51051962
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50583008
84Inositol phosphate metabolism_Homo sapiens_hsa005620.47786084
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46321768
86Histidine metabolism_Homo sapiens_hsa003400.44940311
87Tight junction_Homo sapiens_hsa045300.44542050
88Fatty acid degradation_Homo sapiens_hsa000710.42022125
89Regulation of autophagy_Homo sapiens_hsa041400.41338702
90Ras signaling pathway_Homo sapiens_hsa040140.39476370
91ABC transporters_Homo sapiens_hsa020100.38445142
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38410848
93Oxidative phosphorylation_Homo sapiens_hsa001900.38175343
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38149825
95Alzheimers disease_Homo sapiens_hsa050100.37959987
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35259799
97Rap1 signaling pathway_Homo sapiens_hsa040150.34947132
98Lysine degradation_Homo sapiens_hsa003100.34100657
99Butanoate metabolism_Homo sapiens_hsa006500.33950081
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33819140
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32969681
102Retinol metabolism_Homo sapiens_hsa008300.32276663
103Chemokine signaling pathway_Homo sapiens_hsa040620.29977231
104Ovarian steroidogenesis_Homo sapiens_hsa049130.29791840
105Oocyte meiosis_Homo sapiens_hsa041140.29767114
106Prion diseases_Homo sapiens_hsa050200.28120200
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25704242
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25121806
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24891157
110Mineral absorption_Homo sapiens_hsa049780.24811773
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.24473853
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23255841
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22554683
114VEGF signaling pathway_Homo sapiens_hsa043700.22447648
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.21783152
116Peroxisome_Homo sapiens_hsa041460.20648085
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20341325
118Glycerolipid metabolism_Homo sapiens_hsa005610.19951549
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18541344
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18021383
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17850447
122Vibrio cholerae infection_Homo sapiens_hsa051100.16703480

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