KLHL30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.10917499
2actin-mediated cell contraction (GO:0070252)8.94722131
3cardiac myofibril assembly (GO:0055003)8.54858011
4myofibril assembly (GO:0030239)8.21267253
5regulation of skeletal muscle contraction (GO:0014819)7.85847415
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.74236191
7plasma membrane repair (GO:0001778)6.86931610
8actin filament-based movement (GO:0030048)6.73536496
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.72180602
10cardiac muscle contraction (GO:0060048)6.66997705
11striated muscle contraction (GO:0006941)6.36920410
12actomyosin structure organization (GO:0031032)6.34352852
13sarcoplasmic reticulum calcium ion transport (GO:0070296)6.33065339
14cardiac muscle cell development (GO:0055013)6.29694703
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.17560640
16skeletal muscle contraction (GO:0003009)6.02735045
17cardiac cell development (GO:0055006)5.92645893
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.84040244
19cardiac muscle tissue morphogenesis (GO:0055008)5.83606561
20tricarboxylic acid cycle (GO:0006099)5.60870745
21heart process (GO:0003015)5.58674518
22heart contraction (GO:0060047)5.58674518
23muscle tissue morphogenesis (GO:0060415)5.41158380
24regulation of relaxation of muscle (GO:1901077)5.41072885
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.37474441
26cardiac muscle hypertrophy (GO:0003300)5.36728355
27regulation of sarcomere organization (GO:0060297)5.21798909
28regulation of actin filament-based movement (GO:1903115)5.17878132
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.17591277
30striated muscle hypertrophy (GO:0014897)5.16699942
31response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.08573131
32adult heart development (GO:0007512)5.06208960
33regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.95954936
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.93537578
35ventricular cardiac muscle cell action potential (GO:0086005)4.84788642
36regulation of striated muscle contraction (GO:0006942)4.83997823
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.83831116
38regulation of cell communication by electrical coupling (GO:0010649)4.80600494
39myotube cell development (GO:0014904)4.79374733
40heart trabecula formation (GO:0060347)4.78662513
41behavioral response to nicotine (GO:0035095)4.69116670
42carnitine shuttle (GO:0006853)4.65623858
43muscle hypertrophy (GO:0014896)4.56644022
44muscle contraction (GO:0006936)4.53299022
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.45841360
46skeletal muscle adaptation (GO:0043501)4.38236945
47regulation of acyl-CoA biosynthetic process (GO:0050812)4.35511194
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.33041463
49striated muscle cell development (GO:0055002)4.31175369
50muscle cell fate commitment (GO:0042693)4.30970499
51response to inactivity (GO:0014854)4.30294418
52regulation of membrane repolarization (GO:0060306)4.27745986
53regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.27050733
54energy coupled proton transport, down electrochemical gradient (GO:0015985)4.21830025
55ATP synthesis coupled proton transport (GO:0015986)4.21830025
56regulation of coenzyme metabolic process (GO:0051196)4.20472450
57regulation of cofactor metabolic process (GO:0051193)4.20472450
58bundle of His cell to Purkinje myocyte communication (GO:0086069)4.20294509
59skeletal muscle tissue development (GO:0007519)4.17809261
60muscle system process (GO:0003012)4.16286566
61striated muscle adaptation (GO:0014888)4.11192192
62negative regulation of protein localization to cell surface (GO:2000009)4.08669387
63regulation of the force of heart contraction (GO:0002026)4.07783205
64muscle atrophy (GO:0014889)4.06528838
65negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.01178984
66cardiac muscle hypertrophy in response to stress (GO:0014898)3.96864980
67muscle hypertrophy in response to stress (GO:0003299)3.96864980
68cardiac muscle adaptation (GO:0014887)3.96864980
69fatty acid transmembrane transport (GO:1902001)3.89304880
70regulation of cardioblast differentiation (GO:0051890)3.87020081
71muscle fiber development (GO:0048747)3.85298127
72oxidative phosphorylation (GO:0006119)3.85243041
73cytidine deamination (GO:0009972)3.82426424
74cytidine metabolic process (GO:0046087)3.82426424
75cytidine catabolic process (GO:0006216)3.82426424
76pyrimidine ribonucleoside catabolic process (GO:0046133)3.81304572
77regulation of sequestering of triglyceride (GO:0010889)3.79543230
78negative regulation of striated muscle cell apoptotic process (GO:0010664)3.75349643
79regulation of ATPase activity (GO:0043462)3.73436580
80regulation of ATP catabolic process (GO:1903289)3.73436580
81muscle cell development (GO:0055001)3.71654702
82positive regulation of myotube differentiation (GO:0010831)3.66072588
83creatine metabolic process (GO:0006600)3.62608254
84muscle organ development (GO:0007517)3.59412984
85striated muscle atrophy (GO:0014891)3.57509827
86muscle structure development (GO:0061061)3.56948980
87neuromuscular synaptic transmission (GO:0007274)3.54580459
88regulation of muscle contraction (GO:0006937)3.53248215
89cardiac muscle cell action potential involved in contraction (GO:0086002)3.52352522
90response to muscle activity (GO:0014850)3.50394456
91negative regulation of potassium ion transport (GO:0043267)3.50258249
92skeletal muscle tissue regeneration (GO:0043403)3.49793298
93respiratory electron transport chain (GO:0022904)3.49329100
94ventricular cardiac muscle cell development (GO:0055015)3.49081075
95skeletal muscle fiber development (GO:0048741)3.48700656
96cardiac muscle cell action potential (GO:0086001)3.47151695
97muscle cell cellular homeostasis (GO:0046716)3.46637662
98regulation of action potential (GO:0098900)3.46042008
99negative regulation of nitric-oxide synthase activity (GO:0051001)3.43522464
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40560089
101muscle adaptation (GO:0043500)3.39649111
102electron transport chain (GO:0022900)3.39064398
103regulation of heart rate (GO:0002027)3.37208918
104cell communication involved in cardiac conduction (GO:0086065)3.33057838
105carnitine transmembrane transport (GO:1902603)3.32912411
106synaptic transmission, cholinergic (GO:0007271)3.30737054
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30649752
108positive regulation of fatty acid oxidation (GO:0046321)3.29176446
109positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.27310016
110negative regulation of muscle hypertrophy (GO:0014741)3.26830316
111regulation of muscle system process (GO:0090257)3.26659845
112glycogen catabolic process (GO:0005980)3.26297972
113positive regulation of myoblast differentiation (GO:0045663)3.25611843
114response to caffeine (GO:0031000)3.20286695
115ubiquinone biosynthetic process (GO:0006744)3.16655120
116striated muscle tissue development (GO:0014706)3.15055613
117myoblast fusion (GO:0007520)3.02102760
118otic vesicle formation (GO:0030916)2.98275384
119regulation of potassium ion transmembrane transporter activity (GO:1901016)2.92241591
120ubiquinone metabolic process (GO:0006743)2.87673652
121glycogen biosynthetic process (GO:0005978)2.87200046
122glucan biosynthetic process (GO:0009250)2.87200046
123membrane depolarization during action potential (GO:0086010)2.85617848
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84319404
125response to activity (GO:0014823)2.80974945
126negative regulation of calcium ion transmembrane transport (GO:1903170)2.77026928
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.77026928
128myotube differentiation (GO:0014902)2.76950003
129regulation of calcium ion transmembrane transport (GO:1903169)2.74755846
130regulation of calcium ion transmembrane transporter activity (GO:1901019)2.74755846
131sulfation (GO:0051923)2.74044311
132negative regulation of cardiac muscle tissue growth (GO:0055022)2.73583899
133negative regulation of heart growth (GO:0061117)2.73583899
134glucan catabolic process (GO:0009251)2.72795726
135muscle tissue development (GO:0060537)2.70514552
136neuronal action potential (GO:0019228)2.70507136
137somite development (GO:0061053)2.69382513
138actin-myosin filament sliding (GO:0033275)10.7542620
139muscle filament sliding (GO:0030049)10.7542620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.87547864
2EZH2_22144423_ChIP-Seq_EOC_Human5.12888239
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.89479295
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.67606587
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.36958115
6TBX20_22080862_ChIP-Seq_HEART_Mouse4.20480227
7TBX20_22328084_ChIP-Seq_HEART_Mouse4.20480227
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.82649239
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.76357750
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.68080621
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60226799
12RARG_19884340_ChIP-ChIP_MEFs_Mouse3.52600821
13VDR_22108803_ChIP-Seq_LS180_Human2.91316167
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.81720491
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81032463
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.76854669
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.75312794
18ZNF263_19887448_ChIP-Seq_K562_Human2.54034833
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.50136170
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.49185359
21GBX2_23144817_ChIP-Seq_PC3_Human2.34949874
22NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.28535714
23CLOCK_20551151_ChIP-Seq_293T_Human2.07067700
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00360514
25IGF1R_20145208_ChIP-Seq_DFB_Human1.99857496
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.99314057
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93036616
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92560123
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89676590
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.87995743
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84852330
32* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.83836646
33PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.83592376
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.76894582
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73506518
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71576419
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67961665
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64733199
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.64468551
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.62564712
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61833294
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61812027
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60759954
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.59188539
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58625915
46ER_23166858_ChIP-Seq_MCF-7_Human1.55881944
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55540067
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55102574
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.54364623
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53906938
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53654209
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50351533
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49673461
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47460811
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46885025
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42914359
57ATF3_27146783_Chip-Seq_COLON_Human1.42123100
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42067022
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.39755527
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39328905
61WT1_19549856_ChIP-ChIP_CCG9911_Human1.39185033
62* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38645185
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35425399
64* FUS_26573619_Chip-Seq_HEK293_Human1.35348642
65ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.34929660
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34155640
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31423780
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.31245135
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30931420
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30931420
71* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29331340
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28811018
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28633120
74RACK7_27058665_Chip-Seq_MCF-7_Human1.28562711
75KDM2B_26808549_Chip-Seq_DND41_Human1.27811770
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27255446
77* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26782280
78DROSHA_22980978_ChIP-Seq_HELA_Human1.26577170
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24880935
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24391431
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23803553
82* CRX_20693478_ChIP-Seq_RETINA_Mouse1.23601362
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23500891
84* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22410128
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21177698
86SOX2_19829295_ChIP-Seq_ESCs_Human1.21109634
87NANOG_19829295_ChIP-Seq_ESCs_Human1.21109634
88ESR1_21235772_ChIP-Seq_MCF-7_Human1.20724401
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.20592241
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18820512
91CBP_20019798_ChIP-Seq_JUKART_Human1.18600219
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18600219
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18264442
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17845743
95P300_19829295_ChIP-Seq_ESCs_Human1.17689051
96BCAT_22108803_ChIP-Seq_LS180_Human1.16671617
97SMAD4_21799915_ChIP-Seq_A2780_Human1.16602757
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16459688
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15924520
100* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15252582
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.15243561
102* CJUN_26792858_Chip-Seq_BT549_Human1.13911334
103CTCF_27219007_Chip-Seq_Bcells_Human1.13544779
104* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13066350
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12200418
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12187070
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.12084938
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12058988
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10471523
110* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09943043
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09421441
112* NFE2_27457419_Chip-Seq_LIVER_Mouse1.08879966
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08858597
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08633729
115RNF2_27304074_Chip-Seq_NSC_Mouse1.08398980
116LXR_22292898_ChIP-Seq_THP-1_Human1.08335839
117SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08302635
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.08062773
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07078371
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.06398512
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06319382
122SOX2_21211035_ChIP-Seq_LN229_Gbm1.04435062
123* CTCF_21964334_Chip-Seq_Bcells_Human1.03430144
124TCF4_23295773_ChIP-Seq_U87_Human1.03196448
125STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03179780
126* TP63_22573176_ChIP-Seq_HFKS_Human1.03111485
127ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02643692
128NCOR_22424771_ChIP-Seq_293T_Human1.01407874
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01368122
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01014559
131PIAS1_25552417_ChIP-Seq_VCAP_Human1.01009057
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00141597
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99938594
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99834878
135STAT3_23295773_ChIP-Seq_U87_Human0.99108372
136REST_21632747_ChIP-Seq_MESCs_Mouse0.97967806
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97576295
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.97169593
139RUNX1_27514584_Chip-Seq_MCF-7_Human0.97086285
140FOXH1_21741376_ChIP-Seq_ESCs_Human0.96298241
141* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96076465
142SPI1_20517297_ChIP-Seq_HL60_Human0.95981475
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.95737897
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95724807
145EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94609722
146OCT4_20526341_ChIP-Seq_ESCs_Human0.93678979
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92862807
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92670021
149* P53_22387025_ChIP-Seq_ESCs_Mouse0.92411461
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92336528
151TP53_22573176_ChIP-Seq_HFKS_Human0.92269216
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92192259
153AR_25329375_ChIP-Seq_VCAP_Human0.91742912
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91448785
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90465350
156GATA1_19941826_ChIP-Seq_K562_Human0.90328929
157ZNF274_21170338_ChIP-Seq_K562_Hela0.90092475
158* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87728053
159PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87649606
160GATA1_22025678_ChIP-Seq_K562_Human0.87536545
161GATA2_21666600_ChIP-Seq_HMVEC_Human0.86932295
162TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86375505
163TP53_22127205_ChIP-Seq_IMR90_Human0.83199645
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82666950
165UBF1/2_26484160_Chip-Seq_HMECs_Human0.81295364
166GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80740961
167EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78786503
168* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78008306
169P68_20966046_ChIP-Seq_HELA_Human0.77980566
170TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77805310
171SRF_21415370_ChIP-Seq_HL-1_Mouse0.74724429
172AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74401103
173FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74213758
174DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.73770811
175NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71744762
176TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.71165607
177KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.70229327
178SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70151287
179BCL6_27268052_Chip-Seq_Bcells_Human0.70115438
180TDRD3_21172665_ChIP-Seq_MCF-7_Human0.70094387
181TCF7_22412390_ChIP-Seq_EML_Mouse0.69777713
182CSB_26484114_Chip-Seq_FIBROBLAST_Human0.69282737
183JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68311808
184DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68224115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration5.58567235
2MP0000751_myopathy5.50997593
3MP0002837_dystrophic_cardiac_calcinosis5.34571217
4MP0004084_abnormal_cardiac_muscle5.29313001
5MP0003646_muscle_fatigue4.80279501
6MP0004036_abnormal_muscle_relaxation4.49485828
7MP0004145_abnormal_muscle_electrophysio4.12123968
8MP0004215_abnormal_myocardial_fiber3.76496236
9MP0005330_cardiomyopathy3.67809422
10MP0004087_abnormal_muscle_fiber3.50063315
11MP0002106_abnormal_muscle_physiology3.25316089
12MP0000750_abnormal_muscle_regeneration3.09860390
13MP0005620_abnormal_muscle_contractility3.04386676
14MP0002972_abnormal_cardiac_muscle2.94020404
15MP0002269_muscular_atrophy2.92418367
16MP0000747_muscle_weakness2.87200959
17MP0005369_muscle_phenotype2.67774839
18MP0000759_abnormal_skeletal_muscle2.67389672
19MP0010630_abnormal_cardiac_muscle2.48777050
20MP0008775_abnormal_heart_ventricle2.41071674
21MP0003137_abnormal_impulse_conducting2.39231130
22MP0001544_abnormal_cardiovascular_syste2.23079981
23MP0005385_cardiovascular_system_phenoty2.23079981
24MP0004130_abnormal_muscle_cell2.13890719
25MP0004233_abnormal_muscle_weight2.12631898
26MP0006138_congestive_heart_failure2.08716171
27MP0003950_abnormal_plasma_membrane2.07848080
28MP0003828_pulmonary_edema1.98266603
29MP0003221_abnormal_cardiomyocyte_apopto1.91169905
30MP0004484_altered_response_of1.91141615
31MP0004510_myositis1.75512020
32MP0004085_abnormal_heartbeat1.66384841
33MP0000733_abnormal_muscle_development1.63615596
34MP0004270_analgesia1.63166523
35MP0006036_abnormal_mitochondrial_physio1.60949624
36MP0002127_abnormal_cardiovascular_syste1.52892914
37MP0002102_abnormal_ear_morphology1.49809424
38MP0002332_abnormal_exercise_endurance1.44650931
39MP0002108_abnormal_muscle_morphology1.34784372
40MP0003567_abnormal_fetal_cardiomyocyte1.32447929
41MP0001661_extended_life_span1.30023236
42MP0009780_abnormal_chondrocyte_physiolo1.28407958
43MP0004142_abnormal_muscle_tone1.22519101
44MP0003279_aneurysm1.17316284
45MP0003011_delayed_dark_adaptation1.15567663
46MP0002234_abnormal_pharynx_morphology1.13704476
47MP0000266_abnormal_heart_morphology1.11542929
48MP0003705_abnormal_hypodermis_morpholog1.05405240
49MP0005666_abnormal_adipose_tissue1.03881081
50MP0001485_abnormal_pinna_reflex1.02947085
51MP0008438_abnormal_cutaneous_collagen1.00667417
52MP0002876_abnormal_thyroid_physiology1.00401786
53MP0005646_abnormal_pituitary_gland0.99490251
54MP0003566_abnormal_cell_adhesion0.98249123
55MP0004185_abnormal_adipocyte_glucose0.95982955
56MP0005451_abnormal_body_composition0.91244944
57MP0002638_abnormal_pupillary_reflex0.89961628
58MP0002734_abnormal_mechanical_nocicepti0.89658221
59MP0006035_abnormal_mitochondrial_morpho0.89616351
60MP0003879_abnormal_hair_cell0.87378181
61MP0008872_abnormal_physiological_respon0.86084209
62MP0004272_abnormal_basement_membrane0.84587999
63MP0005623_abnormal_meninges_morphology0.84571166
64MP0000343_altered_response_to0.84329553
65MP0003806_abnormal_nucleotide_metabolis0.79471267
66MP0005266_abnormal_metabolism0.78986448
67MP0006276_abnormal_autonomic_nervous0.78681372
68MP0002128_abnormal_blood_circulation0.77762858
69MP0000767_abnormal_smooth_muscle0.77517711
70MP0005375_adipose_tissue_phenotype0.76009070
71MP0005551_abnormal_eye_electrophysiolog0.74894820
72MP0002272_abnormal_nervous_system0.74512317
73MP0000013_abnormal_adipose_tissue0.72142219
74MP0005503_abnormal_tendon_morphology0.71711672
75MP0005275_abnormal_skin_tensile0.70410786
76MP0002971_abnormal_brown_adipose0.68584978
77MP0005670_abnormal_white_adipose0.67194136
78MP0005165_increased_susceptibility_to0.66414741
79MP0001968_abnormal_touch/_nociception0.66406739
80MP0003195_calcinosis0.66004353
81MP0003045_fibrosis0.60919180
82MP0010368_abnormal_lymphatic_system0.60358016
83MP0000230_abnormal_systemic_arterial0.60341540
84MP0009384_cardiac_valve_regurgitation0.60268916
85MP0002160_abnormal_reproductive_system0.59654942
86MP0009046_muscle_twitch0.56014885
87MP0000049_abnormal_middle_ear0.55644028
88MP0003941_abnormal_skin_development0.55262830
89MP0009745_abnormal_behavioral_response0.55048268
90MP0004885_abnormal_endolymph0.54253703
91MP0005253_abnormal_eye_physiology0.53938948
92MP0002925_abnormal_cardiovascular_devel0.53069407
93MP0001486_abnormal_startle_reflex0.51435878
94MP0000631_abnormal_neuroendocrine_gland0.51348421
95MP0003283_abnormal_digestive_organ0.50673713
96MP0000003_abnormal_adipose_tissue0.49820394
97MP0005645_abnormal_hypothalamus_physiol0.48887330
98MP0010030_abnormal_orbit_morphology0.48580175
99MP0002733_abnormal_thermal_nociception0.48098104
100MP0005332_abnormal_amino_acid0.48009588
101MP0001440_abnormal_grooming_behavior0.47528132
102MP0001986_abnormal_taste_sensitivity0.47193817
103MP0005386_behavior/neurological_phenoty0.46192614
104MP0004924_abnormal_behavior0.46192614
105MP0005187_abnormal_penis_morphology0.45640509
106MP0000762_abnormal_tongue_morphology0.45581316
107MP0003984_embryonic_growth_retardation0.44069808
108MP0002088_abnormal_embryonic_growth/wei0.43653619
109MP0005377_hearing/vestibular/ear_phenot0.43458795
110MP0003878_abnormal_ear_physiology0.43458795
111MP0002067_abnormal_sensory_capabilities0.43375309
112MP0006072_abnormal_retinal_apoptosis0.42964842
113MP0001614_abnormal_blood_vessel0.41754212
114MP0001784_abnormal_fluid_regulation0.41458329
115MP0000026_abnormal_inner_ear0.40764063
116MP0009250_abnormal_appendicular_skeleto0.39087119
117MP0002277_abnormal_respiratory_mucosa0.39044462
118MP0005452_abnormal_adipose_tissue0.38756893
119MP0001501_abnormal_sleep_pattern0.38356470
120MP0002752_abnormal_somatic_nervous0.37873420
121MP0002249_abnormal_larynx_morphology0.37652961
122MP0003385_abnormal_body_wall0.37506796
123MP0001879_abnormal_lymphatic_vessel0.37474907
124MP0003136_yellow_coat_color0.36648952
125MP0001299_abnormal_eye_distance/0.36403313
126MP0006292_abnormal_olfactory_placode0.36221325
127MP0003638_abnormal_response/metabolism_0.35540772
128MP0003948_abnormal_gas_homeostasis0.34909507
129MP0005319_abnormal_enzyme/_coenzyme0.34514913
130MP0002877_abnormal_melanocyte_morpholog0.28713397
131MP0009672_abnormal_birth_weight0.26836355
132MP0002078_abnormal_glucose_homeostasis0.26379950
133MP0002896_abnormal_bone_mineralization0.26044022
134MP0005380_embryogenesis_phenotype0.24771759
135MP0001672_abnormal_embryogenesis/_devel0.24771759
136MP0004197_abnormal_fetal_growth/weight/0.24625193
137MP0004147_increased_porphyrin_level0.24616535
138MP0008961_abnormal_basal_metabolism0.23907590
139MP0003122_maternal_imprinting0.23888289
140MP0003091_abnormal_cell_migration0.23415460
141MP0004134_abnormal_chest_morphology0.23339206
142MP0000372_irregular_coat_pigmentation0.21702100
143MP0002933_joint_inflammation0.20937302
144MP0000428_abnormal_craniofacial_morphol0.20758103
145MP0004043_abnormal_pH_regulation0.20346777
146MP0001730_embryonic_growth_arrest0.19919445
147MP0001958_emphysema0.19673951

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)6.96984429
2Exercise-induced myalgia (HP:0003738)6.88675612
3Calf muscle hypertrophy (HP:0008981)6.67169116
4Muscle hypertrophy of the lower extremities (HP:0008968)6.48398929
5Sudden death (HP:0001699)6.45714628
6Muscle fiber inclusion bodies (HP:0100299)6.12469039
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.12326786
8Type 1 muscle fiber predominance (HP:0003803)5.74987574
9Nemaline bodies (HP:0003798)5.62612036
10Abnormality of the calf musculature (HP:0001430)5.42813777
11Muscle fiber splitting (HP:0003555)5.38751636
12Hyporeflexia of lower limbs (HP:0002600)5.30749235
13Subaortic stenosis (HP:0001682)5.19585655
14Abnormality of the left ventricular outflow tract (HP:0011103)5.19585655
15Ventricular tachycardia (HP:0004756)5.14103580
16EMG: myopathic abnormalities (HP:0003458)4.92626721
17Myoglobinuria (HP:0002913)4.70225566
18Lipoatrophy (HP:0100578)4.33482926
19Atrial fibrillation (HP:0005110)4.29838026
20Difficulty running (HP:0009046)4.10254758
21Distal arthrogryposis (HP:0005684)4.04206957
22Primary atrial arrhythmia (HP:0001692)3.99223979
23Increased connective tissue (HP:0009025)3.98588792
24Right ventricular cardiomyopathy (HP:0011663)3.97246642
25Rhabdomyolysis (HP:0003201)3.92393452
26Supraventricular tachycardia (HP:0004755)3.86040491
27Supraventricular arrhythmia (HP:0005115)3.78899970
28Round ear (HP:0100830)3.70281656
29Asymmetric septal hypertrophy (HP:0001670)3.69815763
30Myopathic facies (HP:0002058)3.65650108
31Dilated cardiomyopathy (HP:0001644)3.65595739
32Myotonia (HP:0002486)3.62830841
33Muscle fiber atrophy (HP:0100295)3.55238268
34Neck muscle weakness (HP:0000467)3.47201035
35Abnormality of skeletal muscle fiber size (HP:0012084)3.36830321
36Difficulty climbing stairs (HP:0003551)3.31425551
37Ventricular arrhythmia (HP:0004308)3.30227699
38Prolonged QT interval (HP:0001657)3.27923055
39Ulnar deviation of the wrist (HP:0003049)3.24744578
40Syncope (HP:0001279)3.24702057
41Muscle stiffness (HP:0003552)3.24278395
42Palpitations (HP:0001962)3.19833257
43Increased variability in muscle fiber diameter (HP:0003557)3.12434180
44Centrally nucleated skeletal muscle fibers (HP:0003687)3.07153690
45Bundle branch block (HP:0011710)2.98081240
46Distal lower limb muscle weakness (HP:0009053)2.97777655
47Generalized muscle weakness (HP:0003324)2.87037595
48Mildly elevated creatine phosphokinase (HP:0008180)2.86675770
49Malignant hyperthermia (HP:0002047)2.85103944
50Gowers sign (HP:0003391)2.76307310
51Calcaneovalgus deformity (HP:0001848)2.74251831
52Areflexia of lower limbs (HP:0002522)2.70630577
53Fetal akinesia sequence (HP:0001989)2.63137533
54EMG: neuropathic changes (HP:0003445)2.62040144
55Fatigable weakness (HP:0003473)2.61351935
56Abnormality of the neuromuscular junction (HP:0003398)2.61351935
57Heart block (HP:0012722)2.57476237
58Ventricular fibrillation (HP:0001663)2.56252524
59Rimmed vacuoles (HP:0003805)2.54047872
60Deformed tarsal bones (HP:0008119)2.51211026
61Abnormal atrioventricular conduction (HP:0005150)2.50028315
62Absent phalangeal crease (HP:0006109)2.49745148
63Scapular winging (HP:0003691)2.49619006
64Weak cry (HP:0001612)2.47717017
65Atrioventricular block (HP:0001678)2.40451019
66Limb-girdle muscle atrophy (HP:0003797)2.37073012
67Abnormal EKG (HP:0003115)2.34212205
68Nonprogressive disorder (HP:0003680)2.30320873
69Bulbar palsy (HP:0001283)2.28360036
70Hypoplastic heart (HP:0001961)2.25993859
71Left ventricular hypertrophy (HP:0001712)2.25590935
72Spinal rigidity (HP:0003306)2.23772234
73Popliteal pterygium (HP:0009756)2.23460591
74Muscular dystrophy (HP:0003560)2.17956955
75Waddling gait (HP:0002515)2.15910699
76Frequent falls (HP:0002359)2.15510432
77Aplasia of the musculature (HP:0100854)2.10035828
78Abnormal mitochondria in muscle tissue (HP:0008316)2.09220397
79Palmoplantar keratoderma (HP:0000982)2.07747373
80Acute necrotizing encephalopathy (HP:0006965)2.06750777
81Hypoplastic ischia (HP:0003175)2.06026042
82Distal lower limb amyotrophy (HP:0008944)2.01843812
83Abnormality of the foot musculature (HP:0001436)2.01779017
84Abnormal finger flexion creases (HP:0006143)2.01477990
85Hip contracture (HP:0003273)1.99808987
86Exercise intolerance (HP:0003546)1.97935174
87Facial diplegia (HP:0001349)1.97069043
88Ragged-red muscle fibers (HP:0003200)1.93592415
89Conjunctival hamartoma (HP:0100780)1.93541772
90Type 2 muscle fiber atrophy (HP:0003554)1.93440118
91Hepatic necrosis (HP:0002605)1.90795631
92Abnormality of the shoulder girdle musculature (HP:0001435)1.87961626
93Foot dorsiflexor weakness (HP:0009027)1.87740404
94Abnormality of placental membranes (HP:0011409)1.86787096
95Amniotic constriction ring (HP:0009775)1.86787096
96Easy fatigability (HP:0003388)1.86162477
97Slender build (HP:0001533)1.84099610
98Proximal amyotrophy (HP:0007126)1.81541781
99Progressive muscle weakness (HP:0003323)1.81179348
100Symphalangism affecting the phalanges of the hand (HP:0009773)1.80606996
101Abnormality of the ischium (HP:0003174)1.77019421
102Respiratory insufficiency due to muscle weakness (HP:0002747)1.75815625
103Abnormality of the calcaneus (HP:0008364)1.75699185
104Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75651793
105Limb-girdle muscle weakness (HP:0003325)1.75021518
106Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68870909
107Mitochondrial inheritance (HP:0001427)1.61274079
108Limited hip movement (HP:0008800)1.61252166
109Progressive macrocephaly (HP:0004481)1.60163722
110Oligomenorrhea (HP:0000876)1.58861933
111Hyperkalemia (HP:0002153)1.57742865
112Long clavicles (HP:0000890)1.54468603
113Abnormal pupillary function (HP:0007686)1.54021917
114Hepatocellular necrosis (HP:0001404)1.53953162
115Akinesia (HP:0002304)1.50889476
116Acute encephalopathy (HP:0006846)1.47129736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.46203538
2TTN5.71701412
3PHKG13.81111420
4PHKG23.81111420
5MYLK3.26207531
6TRIB33.02061799
7PKN22.78559413
8PDK32.78339080
9PDK42.78339080
10DMPK2.69369509
11STK242.67796027
12MUSK2.65380966
13PIK3CA2.39919387
14NEK12.21746870
15FRK2.17393792
16PIK3CG2.05414784
17LMTK21.76721466
18GRK11.72088170
19ILK1.66054530
20BCKDK1.65594723
21ADRBK21.63614292
22NME11.61291646
23STK38L1.60125286
24PDK21.60001535
25PINK11.59833742
26MAP2K31.53916565
27MAP4K21.39515096
28CCNB11.39045364
29TRPM71.38210859
30ZAK1.37874182
31MAP3K71.27225355
32MAPK121.24707277
33MAPKAPK31.22052249
34MARK11.20003149
35MAPK131.11325659
36CDC42BPA1.07749627
37TIE11.07677186
38ROCK11.05717206
39BRSK21.03699410
40BMPR1B1.03332522
41PAK30.97377256
42FLT30.91141804
43TLK10.88695137
44LIMK10.88256968
45PRKD20.87575282
46CAMK2D0.82505266
47MAP3K100.80164185
48PRKD10.78499637
49MAP3K30.74265877
50DAPK30.73640302
51PRKAA10.72365869
52MAP3K50.71913954
53PKN10.71840053
54MARK30.71379378
55WNK30.70984019
56MAPKAPK50.70838141
57NUAK10.70802006
58DAPK20.69676910
59STK160.68296476
60NEK90.68268408
61RIPK10.68010387
62PLK20.66505194
63ROCK20.65796596
64PRKAA20.64085599
65CDK80.62829640
66AKT20.62128469
67ADRBK10.58692061
68CAMK2B0.55237817
69PTK2B0.53778793
70ERBB30.53776807
71ABL20.52746517
72PDGFRA0.52059732
73STK40.50255960
74MOS0.49686382
75OXSR10.48181431
76MAPK40.47707198
77WNK40.45862016
78PRKD30.45370391
79PRKACB0.44399880
80PRKCE0.43849812
81BRSK10.43789194
82STK110.43342995
83MAP3K40.43234104
84PAK20.39779550
85LRRK20.39434210
86MAPK70.38303327
87GRK70.37080345
88CAMK2G0.36893087
89PTK60.36581103
90EEF2K0.34099395
91DYRK20.33942857
92EPHB10.33297490
93ACVR1B0.32827506
94MAP2K40.31519920
95CASK0.31502276
96LATS20.31322071
97SIK10.30698477
98EPHB20.30440292
99LATS10.29981681
100CSNK1G20.29787395
101PRKCG0.29547159
102ICK0.29471457
103PRKG10.29219829
104CAMK2A0.28522844
105MAP2K60.28300549
106RPS6KC10.27976643
107RPS6KL10.27976643
108PRKCA0.27546025
109FER0.27115223
110MAP2K20.26295776
111MAP2K10.25927956
112KDR0.25534814
113RPS6KA60.25483215
114MTOR0.24997986
115EPHA30.24435941
116CAMK10.24258228
117NTRK30.24187627
118PRKACA0.23411180
119STK30.22501719
120MAPK150.22184781
121STK380.21630913
122TGFBR20.21469165
123WNK10.21228463
124INSRR0.21200131
125PRKG20.21002188
126CSNK1D0.20994669
127MAPK110.20229780
128RPS6KB20.20162509
129CAMK40.19359558
130MAPKAPK20.18715692
131MAP2K70.18139230
132NTRK20.17890206
133PRKCQ0.17608624
134DYRK1B0.16793937
135FGFR10.16674354
136CSNK1A10.14858193
137PAK60.14794310
138RPS6KA10.13989605
139MAP3K110.13583759
140RPS6KA30.12678850
141PRKACG0.12542786
142PDPK10.12311124
143STK390.11590138
144NME20.10891882

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.72529423
2Cardiac muscle contraction_Homo sapiens_hsa042604.94577617
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.71609349
4Dilated cardiomyopathy_Homo sapiens_hsa054144.46566307
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.92772381
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.30824947
7Parkinsons disease_Homo sapiens_hsa050123.19822289
8Oxidative phosphorylation_Homo sapiens_hsa001902.94267304
9Propanoate metabolism_Homo sapiens_hsa006402.51952910
10Carbon metabolism_Homo sapiens_hsa012002.50266889
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32356506
12Alzheimers disease_Homo sapiens_hsa050102.31648896
13Nitrogen metabolism_Homo sapiens_hsa009102.09154157
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07367208
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02201374
16Fatty acid degradation_Homo sapiens_hsa000711.97267202
17Huntingtons disease_Homo sapiens_hsa050161.95520424
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.79834461
19Viral myocarditis_Homo sapiens_hsa054161.73957546
20Linoleic acid metabolism_Homo sapiens_hsa005911.73538955
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71142042
22Phototransduction_Homo sapiens_hsa047441.70988095
23Pyruvate metabolism_Homo sapiens_hsa006201.60600930
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54802215
25Sulfur metabolism_Homo sapiens_hsa009201.52575979
26Biosynthesis of amino acids_Homo sapiens_hsa012301.48141252
27Fatty acid metabolism_Homo sapiens_hsa012121.46631691
28Starch and sucrose metabolism_Homo sapiens_hsa005001.40836512
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40721978
30Glucagon signaling pathway_Homo sapiens_hsa049221.33783108
31Focal adhesion_Homo sapiens_hsa045101.29695362
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28425571
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24418149
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21128463
35Sulfur relay system_Homo sapiens_hsa041221.17420866
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16871452
37Insulin signaling pathway_Homo sapiens_hsa049101.13985560
38Tight junction_Homo sapiens_hsa045301.13537698
39Insulin resistance_Homo sapiens_hsa049311.11987104
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.11753865
41Galactose metabolism_Homo sapiens_hsa000521.06269240
42Caffeine metabolism_Homo sapiens_hsa002321.03680363
43HIF-1 signaling pathway_Homo sapiens_hsa040661.03295195
44Oxytocin signaling pathway_Homo sapiens_hsa049211.02132646
45Circadian entrainment_Homo sapiens_hsa047130.96882090
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.89017089
47Selenocompound metabolism_Homo sapiens_hsa004500.88766587
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.87736409
49Nicotine addiction_Homo sapiens_hsa050330.86910631
50ECM-receptor interaction_Homo sapiens_hsa045120.84767999
51RNA polymerase_Homo sapiens_hsa030200.84191951
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81985638
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.80665482
54Salivary secretion_Homo sapiens_hsa049700.79805359
55AMPK signaling pathway_Homo sapiens_hsa041520.79085604
56Calcium signaling pathway_Homo sapiens_hsa040200.78928825
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76232584
58Ether lipid metabolism_Homo sapiens_hsa005650.74518339
59Fructose and mannose metabolism_Homo sapiens_hsa000510.74395563
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73519406
61Olfactory transduction_Homo sapiens_hsa047400.73022180
62Fatty acid elongation_Homo sapiens_hsa000620.72920055
63Morphine addiction_Homo sapiens_hsa050320.71557319
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71381552
65Fat digestion and absorption_Homo sapiens_hsa049750.69235684
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68298816
67Adherens junction_Homo sapiens_hsa045200.66645571
68Arginine and proline metabolism_Homo sapiens_hsa003300.63557170
69Chemical carcinogenesis_Homo sapiens_hsa052040.62295181
70Butanoate metabolism_Homo sapiens_hsa006500.61607772
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61191509
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60579406
73Proteoglycans in cancer_Homo sapiens_hsa052050.60385508
74Regulation of autophagy_Homo sapiens_hsa041400.58237225
75Histidine metabolism_Homo sapiens_hsa003400.56941639
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.56286500
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55483948
78Taste transduction_Homo sapiens_hsa047420.55195895
79Glycerolipid metabolism_Homo sapiens_hsa005610.54191512
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53215855
81Amoebiasis_Homo sapiens_hsa051460.52599823
82Purine metabolism_Homo sapiens_hsa002300.52394599
83PPAR signaling pathway_Homo sapiens_hsa033200.51955572
84GABAergic synapse_Homo sapiens_hsa047270.51582083
85Circadian rhythm_Homo sapiens_hsa047100.50801341
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48408575
87Serotonergic synapse_Homo sapiens_hsa047260.47469173
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45480324
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44939306
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43204983
91Pentose phosphate pathway_Homo sapiens_hsa000300.43029342
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42985164
93Cholinergic synapse_Homo sapiens_hsa047250.41063893
94Lysine degradation_Homo sapiens_hsa003100.40216414
95Phenylalanine metabolism_Homo sapiens_hsa003600.38613144
96Retinol metabolism_Homo sapiens_hsa008300.35127583
97FoxO signaling pathway_Homo sapiens_hsa040680.33524388
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33082811
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32784843
100Glutamatergic synapse_Homo sapiens_hsa047240.32427282
101Arachidonic acid metabolism_Homo sapiens_hsa005900.32377974
102ABC transporters_Homo sapiens_hsa020100.31648657
103One carbon pool by folate_Homo sapiens_hsa006700.31469899
104Folate biosynthesis_Homo sapiens_hsa007900.30952748
105Pancreatic secretion_Homo sapiens_hsa049720.30854187
106beta-Alanine metabolism_Homo sapiens_hsa004100.30827793
107Mineral absorption_Homo sapiens_hsa049780.29974639
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29524231
109Platelet activation_Homo sapiens_hsa046110.28277374
110Renal cell carcinoma_Homo sapiens_hsa052110.28017716
111Amphetamine addiction_Homo sapiens_hsa050310.28004277
112mTOR signaling pathway_Homo sapiens_hsa041500.25488721
113Type II diabetes mellitus_Homo sapiens_hsa049300.24520512
114Fatty acid biosynthesis_Homo sapiens_hsa000610.23464564
115Gastric acid secretion_Homo sapiens_hsa049710.21391300
116Arginine biosynthesis_Homo sapiens_hsa002200.21021030
117Tryptophan metabolism_Homo sapiens_hsa003800.20315646
118VEGF signaling pathway_Homo sapiens_hsa043700.19394324
119Metabolic pathways_Homo sapiens_hsa011000.18924235
120GnRH signaling pathway_Homo sapiens_hsa049120.18922607
121Renin secretion_Homo sapiens_hsa049240.18863927
122Hippo signaling pathway_Homo sapiens_hsa043900.18177785
123Small cell lung cancer_Homo sapiens_hsa052220.17520079
124cAMP signaling pathway_Homo sapiens_hsa040240.17357653
125MAPK signaling pathway_Homo sapiens_hsa040100.17241942
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16014790
127Tyrosine metabolism_Homo sapiens_hsa003500.14416894
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12940086
129Peroxisome_Homo sapiens_hsa041460.12859758
130Insulin secretion_Homo sapiens_hsa049110.11656483
131Proteasome_Homo sapiens_hsa030500.10441543
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09952783
133Melanogenesis_Homo sapiens_hsa049160.08518048
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07360566
135Basal cell carcinoma_Homo sapiens_hsa052170.06252351
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05287351
137MicroRNAs in cancer_Homo sapiens_hsa052060.04975065
138Gap junction_Homo sapiens_hsa045400.04945732
139HTLV-I infection_Homo sapiens_hsa051660.04376846
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.03632723
141Toxoplasmosis_Homo sapiens_hsa051450.03569896
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.03303092
143Ovarian steroidogenesis_Homo sapiens_hsa049130.02897984
144Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.02608483
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.02357197
146Protein digestion and absorption_Homo sapiens_hsa049740.01216946
147RNA degradation_Homo sapiens_hsa030180.01003510

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