KLHL32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.18941975
2axon ensheathment in central nervous system (GO:0032291)7.18941975
3short-term memory (GO:0007614)6.71627686
4negative regulation of execution phase of apoptosis (GO:1900118)6.37871333
5presynaptic membrane assembly (GO:0097105)5.88561679
6presynaptic membrane organization (GO:0097090)5.37104614
7synaptic vesicle maturation (GO:0016188)5.14394571
8postsynaptic membrane organization (GO:0001941)5.13896375
9positive regulation of protein kinase C signaling (GO:0090037)4.97603886
10glutamate secretion (GO:0014047)4.96751013
11synaptic vesicle exocytosis (GO:0016079)4.69051891
12gamma-aminobutyric acid signaling pathway (GO:0007214)4.61834429
13neuron cell-cell adhesion (GO:0007158)4.55232425
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.43789130
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.42760804
16metanephric tubule development (GO:0072170)4.41542992
17metanephric nephron tubule development (GO:0072234)4.41542992
18retina layer formation (GO:0010842)4.39438027
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39063415
20limb bud formation (GO:0060174)4.36631606
21gamma-aminobutyric acid transport (GO:0015812)4.35659055
22vocalization behavior (GO:0071625)4.33325530
23L-amino acid import (GO:0043092)4.30855118
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23982600
25cilium or flagellum-dependent cell motility (GO:0001539)4.23538129
26neurotransmitter secretion (GO:0007269)4.17395335
27regulation of synaptic vesicle exocytosis (GO:2000300)4.11709308
28synaptic transmission, glutamatergic (GO:0035249)4.10380575
29oligodendrocyte differentiation (GO:0048709)4.02556396
30metanephric nephron epithelium development (GO:0072243)4.01381194
31neuron-neuron synaptic transmission (GO:0007270)3.99694333
32neurotransmitter-gated ion channel clustering (GO:0072578)3.95713563
33regulation of timing of cell differentiation (GO:0048505)3.88072400
34eyelid development in camera-type eye (GO:0061029)3.82265579
35regulation of synaptic vesicle transport (GO:1902803)3.82014964
36cellular potassium ion homeostasis (GO:0030007)3.76549413
37metanephric epithelium development (GO:0072207)3.75877517
38photoreceptor cell differentiation (GO:0046530)3.75389551
39eye photoreceptor cell differentiation (GO:0001754)3.75389551
40neuronal ion channel clustering (GO:0045161)3.74273579
41negative regulation of keratinocyte proliferation (GO:0010839)3.74171847
42neuronal action potential propagation (GO:0019227)3.72099049
43amino acid import (GO:0043090)3.71795665
44glutamate receptor signaling pathway (GO:0007215)3.71435699
45GMP metabolic process (GO:0046037)3.65910465
46cochlea development (GO:0090102)3.63637233
47locomotory exploration behavior (GO:0035641)3.62654000
48epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.58402282
49cerebellar granule cell differentiation (GO:0021707)3.56684312
50neurotransmitter transport (GO:0006836)3.51218317
51auditory behavior (GO:0031223)3.49863669
52exploration behavior (GO:0035640)3.47280628
53sodium ion export (GO:0071436)3.44798469
54negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44386016
55neurotransmitter uptake (GO:0001504)3.42643539
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39918332
57regulation of neurotransmitter levels (GO:0001505)3.39746231
58myelination (GO:0042552)3.36354054
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34327169
60axon ensheathment (GO:0008366)3.33069363
61ensheathment of neurons (GO:0007272)3.33069363
62axonemal dynein complex assembly (GO:0070286)3.32988323
63facial nerve structural organization (GO:0021612)3.32971449
64regulation of development, heterochronic (GO:0040034)3.32077648
65long-chain fatty acid biosynthetic process (GO:0042759)3.32070366
66fatty acid elongation (GO:0030497)3.32024267
67acidic amino acid transport (GO:0015800)3.30317368
68cilium movement (GO:0003341)3.28191749
69dendritic spine morphogenesis (GO:0060997)3.27837049
70nephron epithelium development (GO:0072009)3.26594318
71pyrimidine nucleobase catabolic process (GO:0006208)3.25093615
72cranial nerve structural organization (GO:0021604)3.24774571
73response to auditory stimulus (GO:0010996)3.24145955
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.23997053
75regulation of neuronal synaptic plasticity (GO:0048168)3.23596460
76regulation of voltage-gated calcium channel activity (GO:1901385)3.18039187
77mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17618018
78mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17618018
79regulation of synapse structural plasticity (GO:0051823)3.15157594
80negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.15124924
81nephron tubule development (GO:0072080)3.14908576
82C4-dicarboxylate transport (GO:0015740)3.14316975
83melanin metabolic process (GO:0006582)3.12828631
84regulation of protein kinase A signaling (GO:0010738)3.12147286
85glycosphingolipid biosynthetic process (GO:0006688)3.12022235
86melanin biosynthetic process (GO:0042438)3.11663568
87establishment of mitochondrion localization (GO:0051654)3.11165068
88positive regulation of dendritic spine development (GO:0060999)3.10540877
89regulation of excitatory postsynaptic membrane potential (GO:0060079)3.09670739
90positive regulation of calcium ion import (GO:0090280)3.08550078
91tachykinin receptor signaling pathway (GO:0007217)3.07504831
92regulation of neurotransmitter secretion (GO:0046928)3.07333183
93retinal cone cell development (GO:0046549)3.05004448
94potassium ion import (GO:0010107)3.02944524
95positive regulation of synapse maturation (GO:0090129)3.02802718
96enteric nervous system development (GO:0048484)3.02568815
97cerebral cortex radially oriented cell migration (GO:0021799)3.01230363
98organ growth (GO:0035265)3.01177612
99mechanosensory behavior (GO:0007638)3.01086092
100epithelial cilium movement (GO:0003351)3.00765923
101positive regulation of membrane potential (GO:0045838)3.00097331
102response to histamine (GO:0034776)2.98966875
103axonal fasciculation (GO:0007413)2.98857565
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.98288391
105regulation of dendritic spine morphogenesis (GO:0061001)2.96275898
106potassium ion homeostasis (GO:0055075)2.95928264
107layer formation in cerebral cortex (GO:0021819)2.95141202
108long-term synaptic potentiation (GO:0060291)2.95041034
109negative regulation of neurotransmitter transport (GO:0051589)2.94824259
110adult walking behavior (GO:0007628)2.94716705
111regulation of postsynaptic membrane potential (GO:0060078)2.94571975
112regulation of pigment cell differentiation (GO:0050932)2.94388010
113regulation of neurotransmitter transport (GO:0051588)2.93986956
114negative regulation of protein localization to cell surface (GO:2000009)2.93686772
115innervation (GO:0060384)2.93622491
116membrane depolarization during action potential (GO:0086010)2.93401882
117collecting duct development (GO:0072044)2.93275191
118regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93196751
119proline transport (GO:0015824)2.91808066
120cranial nerve morphogenesis (GO:0021602)2.91635191
121L-glutamate transport (GO:0015813)2.91559606
122regulation of glutamate receptor signaling pathway (GO:1900449)2.90804829
123synaptic transmission (GO:0007268)2.89080907
124transmission of nerve impulse (GO:0019226)2.88510331
125positive regulation of cellular amine metabolic process (GO:0033240)2.87798112
126long-term memory (GO:0007616)2.87304211
127nucleobase catabolic process (GO:0046113)2.87050373
128negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.86807446
129neuromuscular synaptic transmission (GO:0007274)2.86039068
130synaptic vesicle endocytosis (GO:0048488)2.85780993
131negative regulation of neurotransmitter secretion (GO:0046929)2.85257252
132positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.85063302
133regulation of protein kinase C signaling (GO:0090036)2.84782995
134regulation of vesicle fusion (GO:0031338)2.84074902
135regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.83764633
136synapse assembly (GO:0007416)2.83756850
137renal tubule development (GO:0061326)2.82205814
138cellular sodium ion homeostasis (GO:0006883)2.81672518
139righting reflex (GO:0060013)2.81546041
140cranial nerve development (GO:0021545)2.80044818
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79994406
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78290019
143neuron remodeling (GO:0016322)2.76701880
144spinal cord motor neuron differentiation (GO:0021522)2.76326400
145positive regulation of synapse assembly (GO:0051965)2.75481689
146regulation of somitogenesis (GO:0014807)2.73373848
147mesonephros development (GO:0001823)2.73200561
148secondary metabolite biosynthetic process (GO:0044550)2.72611061
149positive regulation of protein tyrosine kinase activity (GO:0061098)2.72053621
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70735671
151regulation of catecholamine metabolic process (GO:0042069)2.69601504
152regulation of dopamine metabolic process (GO:0042053)2.69601504
153otic vesicle formation (GO:0030916)2.66917643
154membrane assembly (GO:0071709)2.65594150
155calcium ion import (GO:0070509)2.64677054
156regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64318575
157import into cell (GO:0098657)2.64272606
158nonmotile primary cilium assembly (GO:0035058)2.58822825
159protein localization to synapse (GO:0035418)2.57920811
160sympathetic nervous system development (GO:0048485)2.57631310
161neuron recognition (GO:0008038)2.57339074
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.55717623
163regulation of neuron projection regeneration (GO:0070570)2.55561850
164regulation of axon regeneration (GO:0048679)2.55561850
165photoreceptor cell maintenance (GO:0045494)2.54878241
166dopamine biosynthetic process (GO:0042416)2.54107553
167lymphoid progenitor cell differentiation (GO:0002320)2.53036961
168startle response (GO:0001964)2.52831047
169ionotropic glutamate receptor signaling pathway (GO:0035235)2.52774489
170glial cell differentiation (GO:0010001)2.51978435
171GPI anchor biosynthetic process (GO:0006506)2.51771328
172developmental pigmentation (GO:0048066)2.51614040
173protein palmitoylation (GO:0018345)2.50658891
174cell differentiation in spinal cord (GO:0021515)2.50629063
175magnesium ion transport (GO:0015693)2.49341146
176branch elongation of an epithelium (GO:0060602)2.47526290
177Sertoli cell development (GO:0060009)2.46443937
178regulation of feeding behavior (GO:0060259)2.45715233
179response to methylmercury (GO:0051597)2.45493312
180spinal cord association neuron differentiation (GO:0021527)2.45450939
181anatomical structure arrangement (GO:0048532)2.43703185
182positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41383960
183keratinocyte development (GO:0003334)2.41004271
184cornea development in camera-type eye (GO:0061303)2.40152734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.12070550
2GBX2_23144817_ChIP-Seq_PC3_Human3.17753158
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02785285
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.89319949
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80109350
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.76126115
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74628222
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65117918
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57425765
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53922308
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53922308
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53403839
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.47441932
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45770390
15VDR_22108803_ChIP-Seq_LS180_Human2.44121299
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42260328
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39998287
18TAF15_26573619_Chip-Seq_HEK293_Human2.32081912
19AR_21572438_ChIP-Seq_LNCaP_Human2.31871595
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29897314
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26358290
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22916378
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.15744510
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.15247525
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14019101
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11140538
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08018020
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07694784
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.05224493
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95452042
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95080018
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.91467764
33RNF2_27304074_Chip-Seq_NSC_Mouse1.85135803
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80996221
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72120607
36IGF1R_20145208_ChIP-Seq_DFB_Human1.68657510
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64715555
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62738725
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60958607
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59882704
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58207111
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57886643
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56626389
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56447454
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.54919034
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54265593
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51573697
48P300_19829295_ChIP-Seq_ESCs_Human1.51310082
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.47700177
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46288476
51ER_23166858_ChIP-Seq_MCF-7_Human1.45584556
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.43100417
53* TCF4_23295773_ChIP-Seq_U87_Human1.42432631
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.42189132
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37989702
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.37051260
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35659193
58AR_25329375_ChIP-Seq_VCAP_Human1.33453561
59FUS_26573619_Chip-Seq_HEK293_Human1.33344255
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30056161
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29444590
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28380581
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.27828025
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.27612630
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27274415
66IRF1_19129219_ChIP-ChIP_H3396_Human1.26914580
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.26539597
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25754731
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25280920
70SMAD4_21799915_ChIP-Seq_A2780_Human1.25079932
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.24010278
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23701416
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.23631517
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.21021715
75ZNF274_21170338_ChIP-Seq_K562_Hela1.20003269
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.19137064
77CBP_20019798_ChIP-Seq_JUKART_Human1.17927847
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17927847
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17612111
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17482937
81NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17044506
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16834954
83AR_19668381_ChIP-Seq_PC3_Human1.16595446
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.16244474
85P53_22387025_ChIP-Seq_ESCs_Mouse1.16068220
86BCAT_22108803_ChIP-Seq_LS180_Human1.15858126
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15844430
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12582937
89P300_18555785_Chip-Seq_ESCs_Mouse1.12191634
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12032600
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11996075
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.11179747
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.09968855
94TP53_18474530_ChIP-ChIP_U2OS_Human1.09351401
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.09078016
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.07444324
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06851857
98RUNX2_22187159_ChIP-Seq_PCA_Human1.06375544
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.05072825
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04706676
101EWS_26573619_Chip-Seq_HEK293_Human1.03994737
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03759558
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.02755896
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02679041
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01947151
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.00467795
107KDM2B_26808549_Chip-Seq_REH_Human1.00338572
108NMYC_18555785_Chip-Seq_ESCs_Mouse1.00217514
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99478233
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99478233
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98877983
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98385746
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.97539252
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97495115
115DROSHA_22980978_ChIP-Seq_HELA_Human0.97079779
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96623783
117TCF4_22108803_ChIP-Seq_LS180_Human0.96141650
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95944618
119KLF4_18555785_Chip-Seq_ESCs_Mouse0.95702098
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95259626
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.95206043
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94312814
123SOX2_18555785_Chip-Seq_ESCs_Mouse0.93423393
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93300054
125NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92874480
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92351265
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92275179
128ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89759794
129REST_18959480_ChIP-ChIP_MESCs_Mouse0.88724907
130* STAT3_23295773_ChIP-Seq_U87_Human0.88716272
131SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88368990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.06407891
2MP0005409_darkened_coat_color4.81968080
3MP0004381_abnormal_hair_follicle4.56904142
4MP0001188_hyperpigmentation4.51217590
5MP0003880_abnormal_central_pattern4.10750386
6MP0001984_abnormal_olfaction2.79635190
7MP0004742_abnormal_vestibular_system2.51337151
8MP0005423_abnormal_somatic_nervous2.39496556
9MP0009379_abnormal_foot_pigmentation2.31051490
10MP0006292_abnormal_olfactory_placode2.20156042
11MP0005171_absent_coat_pigmentation2.07466656
12MP0000920_abnormal_myelination1.97425840
13MP0008877_abnormal_DNA_methylation1.94979269
14MP0002822_catalepsy1.93681005
15MP0001968_abnormal_touch/_nociception1.93508351
16MP0002102_abnormal_ear_morphology1.92459549
17MP0005174_abnormal_tail_pigmentation1.90032438
18MP0001486_abnormal_startle_reflex1.90020484
19MP0002272_abnormal_nervous_system1.81720050
20MP0000566_synostosis1.80821474
21MP0003690_abnormal_glial_cell1.78376895
22MP0000015_abnormal_ear_pigmentation1.72960801
23MP0004270_analgesia1.72646272
24MP0004142_abnormal_muscle_tone1.65226018
25MP0003122_maternal_imprinting1.61170379
26MP0005386_behavior/neurological_phenoty1.58915050
27MP0004924_abnormal_behavior1.58915050
28MP0003633_abnormal_nervous_system1.58843375
29MP0000778_abnormal_nervous_system1.56501603
30MP0003879_abnormal_hair_cell1.56468740
31MP0003787_abnormal_imprinting1.51111408
32MP0004811_abnormal_neuron_physiology1.50692139
33MP0003938_abnormal_ear_development1.50454524
34MP0005379_endocrine/exocrine_gland_phen1.49085234
35MP0003941_abnormal_skin_development1.48519104
36MP0009745_abnormal_behavioral_response1.48059875
37MP0000631_abnormal_neuroendocrine_gland1.42794580
38MP0002067_abnormal_sensory_capabilities1.42311758
39MP0002249_abnormal_larynx_morphology1.39970058
40MP0002064_seizures1.37400560
41MP0003631_nervous_system_phenotype1.34561833
42MP0002734_abnormal_mechanical_nocicepti1.34479177
43MP0002638_abnormal_pupillary_reflex1.34259398
44MP0002177_abnormal_outer_ear1.34116257
45MP0003635_abnormal_synaptic_transmissio1.33797050
46MP0001905_abnormal_dopamine_level1.33618935
47MP0009780_abnormal_chondrocyte_physiolo1.31326074
48MP0005551_abnormal_eye_electrophysiolog1.30588109
49MP0009250_abnormal_appendicular_skeleto1.30054769
50MP0001986_abnormal_taste_sensitivity1.28516213
51MP0006072_abnormal_retinal_apoptosis1.27300567
52MP0001970_abnormal_pain_threshold1.26118698
53MP0002653_abnormal_ependyma_morphology1.25802978
54MP0003329_amyloid_beta_deposits1.25331425
55MP0000569_abnormal_digit_pigmentation1.22309011
56MP0000026_abnormal_inner_ear1.22019066
57MP0005645_abnormal_hypothalamus_physiol1.21936463
58MP0000049_abnormal_middle_ear1.19680588
59MP0006276_abnormal_autonomic_nervous1.18482536
60MP0008260_abnormal_autophagy1.17203497
61MP0003011_delayed_dark_adaptation1.16102875
62MP0003724_increased_susceptibility_to1.15124575
63MP0009046_muscle_twitch1.12809669
64MP0002752_abnormal_somatic_nervous1.12216970
65MP0003632_abnormal_nervous_system1.10754096
66MP0002277_abnormal_respiratory_mucosa1.10048532
67MP0003121_genomic_imprinting1.08536969
68MP0000613_abnormal_salivary_gland1.06584991
69MP0001963_abnormal_hearing_physiology1.06291063
70MP0001177_atelectasis1.04870066
71MP0002751_abnormal_autonomic_nervous1.04016721
72MP0005646_abnormal_pituitary_gland1.03804009
73MP0000762_abnormal_tongue_morphology1.02221465
74MP0002557_abnormal_social/conspecific_i1.01733284
75MP0001346_abnormal_lacrimal_gland1.01418892
76MP0001485_abnormal_pinna_reflex1.01140436
77MP0004145_abnormal_muscle_electrophysio1.00843777
78MP0001502_abnormal_circadian_rhythm1.00234919
79MP0002184_abnormal_innervation1.00053055
80MP0002572_abnormal_emotion/affect_behav0.99910780
81MP0000467_abnormal_esophagus_morphology0.99549611
82MP0002882_abnormal_neuron_morphology0.98881516
83MP0001340_abnormal_eyelid_morphology0.97680892
84MP0002229_neurodegeneration0.96864469
85MP0004859_abnormal_synaptic_plasticity0.96705195
86MP0004147_increased_porphyrin_level0.96073421
87MP0001501_abnormal_sleep_pattern0.95103592
88MP0002938_white_spotting0.94180327
89MP0002733_abnormal_thermal_nociception0.93978697
90MP0005499_abnormal_olfactory_system0.92263548
91MP0005394_taste/olfaction_phenotype0.92263548
92MP0002909_abnormal_adrenal_gland0.91766400
93MP0010386_abnormal_urinary_bladder0.91723136
94MP0000462_abnormal_digestive_system0.91421869
95MP0003950_abnormal_plasma_membrane0.91179591
96MP0008569_lethality_at_weaning0.90808099
97MP0001529_abnormal_vocalization0.90538809
98MP0003937_abnormal_limbs/digits/tail_de0.90461060
99MP0002163_abnormal_gland_morphology0.88750629
100MP0000579_abnormal_nail_morphology0.87792008
101MP0002095_abnormal_skin_pigmentation0.87722870
102MP0003634_abnormal_glial_cell0.87248143
103MP0003315_abnormal_perineum_morphology0.87150586
104MP0004885_abnormal_endolymph0.86669913
105MP0000383_abnormal_hair_follicle0.86416195
106MP0005187_abnormal_penis_morphology0.86334277
107MP0002735_abnormal_chemical_nociception0.86299285
108MP0000955_abnormal_spinal_cord0.86154565
109MP0004133_heterotaxia0.85332757
110MP0005595_abnormal_vascular_smooth0.83732119
111MP0002069_abnormal_eating/drinking_beha0.83532022
112MP0008872_abnormal_physiological_respon0.79716177
113MP0002736_abnormal_nociception_after0.78681754
114MP0005075_abnormal_melanosome_morpholog0.78114184
115MP0005195_abnormal_posterior_eye0.76717026
116MP0002063_abnormal_learning/memory/cond0.76007223
117MP0000647_abnormal_sebaceous_gland0.75528640
118MP0001440_abnormal_grooming_behavior0.75229666
119MP0008875_abnormal_xenobiotic_pharmacok0.74547884
120MP0002066_abnormal_motor_capabilities/c0.73886905
121MP0005253_abnormal_eye_physiology0.73258040
122MP0002928_abnormal_bile_duct0.72510503
123MP0003698_abnormal_male_reproductive0.72031833
124MP0003123_paternal_imprinting0.71754627
125MP0001661_extended_life_span0.69675999
126MP0001299_abnormal_eye_distance/0.69431974
127MP0003385_abnormal_body_wall0.67511921
128MP0002090_abnormal_vision0.65195293
129MP0001664_abnormal_digestion0.64988171
130MP0003195_calcinosis0.64678095
131MP0005167_abnormal_blood-brain_barrier0.63752474
132MP0004043_abnormal_pH_regulation0.63534995
133MP0008874_decreased_physiological_sensi0.62620818
134MP0002233_abnormal_nose_morphology0.62565276
135MP0008789_abnormal_olfactory_epithelium0.62107309
136MP0002152_abnormal_brain_morphology0.61887213
137MP0002876_abnormal_thyroid_physiology0.61257955
138MP0003861_abnormal_nervous_system0.59170668
139MP0002160_abnormal_reproductive_system0.52690586
140MP0002234_abnormal_pharynx_morphology0.52687124

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the axillary hair (HP:0100134)5.95341302
2Abnormality of secondary sexual hair (HP:0009888)5.95341302
3Abnormal sex determination (HP:0012244)5.30938361
4Sex reversal (HP:0012245)5.30938361
5Myokymia (HP:0002411)4.88963865
6Obstructive sleep apnea (HP:0002870)4.72217468
7Focal seizures (HP:0007359)4.40322553
8Febrile seizures (HP:0002373)4.21680623
9Abnormality of the corticospinal tract (HP:0002492)4.13875440
10Alacrima (HP:0000522)3.97703975
11Atonic seizures (HP:0010819)3.85352519
12Action tremor (HP:0002345)3.85276216
13Epileptic encephalopathy (HP:0200134)3.77594568
14Progressive cerebellar ataxia (HP:0002073)3.72814091
15Peripheral hypomyelination (HP:0007182)3.60893341
16Parakeratosis (HP:0001036)3.55125212
17Decreased lacrimation (HP:0000633)3.38287872
18Spastic gait (HP:0002064)3.37692793
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36487933
20Optic nerve hypoplasia (HP:0000609)3.33636948
21Ankle clonus (HP:0011448)3.29538992
22Septo-optic dysplasia (HP:0100842)3.23482233
23Scanning speech (HP:0002168)3.23173225
24Generalized tonic-clonic seizures (HP:0002069)3.21001297
25Attenuation of retinal blood vessels (HP:0007843)3.19420016
26Limb dystonia (HP:0002451)3.15873458
27Abnormal eating behavior (HP:0100738)3.13016905
28Absent speech (HP:0001344)3.11039088
29Split foot (HP:0001839)3.07478141
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.06017514
31Absent/shortened dynein arms (HP:0200106)3.06017514
32Abnormal ciliary motility (HP:0012262)3.03170686
33Sleep apnea (HP:0010535)3.02078049
34White forelock (HP:0002211)3.00117286
35Dialeptic seizures (HP:0011146)2.98203196
36Hyperventilation (HP:0002883)2.96819507
37Urinary urgency (HP:0000012)2.93831228
38Impaired vibration sensation in the lower limbs (HP:0002166)2.92513886
39Patchy hypopigmentation of hair (HP:0011365)2.86453014
40Optic disc pallor (HP:0000543)2.83708890
41Absence seizures (HP:0002121)2.82218403
42Esotropia (HP:0000565)2.81625962
43Absent septum pellucidum (HP:0001331)2.81405990
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80877347
45Polyphagia (HP:0002591)2.80226789
46Concave nail (HP:0001598)2.77564899
47Abnormal respiratory motile cilium physiology (HP:0012261)2.77110916
48Urinary bladder sphincter dysfunction (HP:0002839)2.69859873
49Dysdiadochokinesis (HP:0002075)2.67436489
50Hemiparesis (HP:0001269)2.65479979
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.64834994
52Oligodactyly (hands) (HP:0001180)2.63906001
53Gait imbalance (HP:0002141)2.62952376
54Supranuclear gaze palsy (HP:0000605)2.61145300
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.60976810
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.60976810
57Abnormality of the septum pellucidum (HP:0007375)2.58880413
58True hermaphroditism (HP:0010459)2.57708155
59Abnormal respiratory motile cilium morphology (HP:0005938)2.57203476
60Abnormal respiratory epithelium morphology (HP:0012253)2.57203476
61Nonprogressive disorder (HP:0003680)2.54740204
62Gaze-evoked nystagmus (HP:0000640)2.54719457
63Postural instability (HP:0002172)2.50599252
64Broad-based gait (HP:0002136)2.49157081
65Retinal dysplasia (HP:0007973)2.47103970
66Epileptiform EEG discharges (HP:0011182)2.44083492
67Lower limb muscle weakness (HP:0007340)2.43120799
68Drooling (HP:0002307)2.40960070
69Abnormality of binocular vision (HP:0011514)2.39909758
70Diplopia (HP:0000651)2.39909758
71Truncal ataxia (HP:0002078)2.38509577
72Thyroid-stimulating hormone excess (HP:0002925)2.38231428
73Chin dimple (HP:0010751)2.37752333
74Morphological abnormality of the pyramidal tract (HP:0002062)2.36649730
75Focal motor seizures (HP:0011153)2.34282361
76Dysmetria (HP:0001310)2.32083348
77Congenital sensorineural hearing impairment (HP:0008527)2.28088463
78Chronic hepatic failure (HP:0100626)2.25891421
79Increased circulating renin level (HP:0000848)2.25852073
80Torticollis (HP:0000473)2.24763595
81EEG with generalized epileptiform discharges (HP:0011198)2.24586174
82Gonadal dysgenesis (HP:0000133)2.21167967
83Intention tremor (HP:0002080)2.20920919
84Hypsarrhythmia (HP:0002521)2.20847804
85Excessive salivation (HP:0003781)2.20386052
86Neurofibrillary tangles (HP:0002185)2.20153748
87Mutism (HP:0002300)2.20122176
88Medial flaring of the eyebrow (HP:0010747)2.18881661
89Pancreatic fibrosis (HP:0100732)2.18658791
90Abnormality of macular pigmentation (HP:0008002)2.17292354
91Hypoplasia of the iris (HP:0007676)2.16718182
92Congenital primary aphakia (HP:0007707)2.16269984
93Amyotrophic lateral sclerosis (HP:0007354)2.15769818
94Hypomagnesemia (HP:0002917)2.15426122
95Aplasia/hypoplasia of the uterus (HP:0008684)2.14614651
96Molar tooth sign on MRI (HP:0002419)2.13663452
97Abnormality of midbrain morphology (HP:0002418)2.13663452
98Hemiplegia (HP:0002301)2.13630820
99Laryngomalacia (HP:0001601)2.10594254
100Cupped ear (HP:0000378)2.10311844
101Abnormality of the labia minora (HP:0012880)2.09741397
102Intellectual disability, moderate (HP:0002342)2.07751559
103Status epilepticus (HP:0002133)2.06915147
104Genital tract atresia (HP:0001827)2.06282970
105Onion bulb formation (HP:0003383)2.06047545
106Sensory axonal neuropathy (HP:0003390)2.04016950
107Tubulointerstitial nephritis (HP:0001970)2.03053215
108Genetic anticipation (HP:0003743)2.02980790
109Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02947150
110Nephronophthisis (HP:0000090)2.01291451
111Nephrogenic diabetes insipidus (HP:0009806)1.99482645
112Osteomalacia (HP:0002749)1.99249833
113Vaginal atresia (HP:0000148)1.97831119
114Rhinitis (HP:0012384)1.97428297
115Pancreatic cysts (HP:0001737)1.97192373
116Abnormality of magnesium homeostasis (HP:0004921)1.96947451
117Generalized hypotonia (HP:0001290)1.96456673
118Renal Fanconi syndrome (HP:0001994)1.96112568
119Specific learning disability (HP:0001328)1.94831436
120Mixed hearing impairment (HP:0000410)1.93367683
121Conical tooth (HP:0000698)1.93288996
122Poor eye contact (HP:0000817)1.92088863
123Short tibia (HP:0005736)1.91822339
124Asplenia (HP:0001746)1.91256607
1253-Methylglutaconic aciduria (HP:0003535)1.91002514
126Renal agenesis (HP:0000104)1.90892920
127Morphological abnormality of the inner ear (HP:0011390)1.89862051
128Decreased central vision (HP:0007663)1.89304758
129Bile duct proliferation (HP:0001408)1.88514680
130Abnormal biliary tract physiology (HP:0012439)1.88514680
131Increased hepatocellular lipid droplets (HP:0006565)1.88266156
132Supernumerary spleens (HP:0009799)1.88024194
133Male pseudohermaphroditism (HP:0000037)1.87163838
134Abnormal auditory evoked potentials (HP:0006958)1.87124138
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86256741
136Amblyopia (HP:0000646)1.86060000
137Humeroradial synostosis (HP:0003041)1.85448211
138Synostosis involving the elbow (HP:0003938)1.85448211
139Paraplegia (HP:0010550)1.84688495
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.84450616
141Partial duplication of thumb phalanx (HP:0009944)1.84072364
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.83388127
143Chronic bronchitis (HP:0004469)1.83254905
144Impaired vibratory sensation (HP:0002495)1.83013989
145Polydipsia (HP:0001959)1.82600534
146Abnormal drinking behavior (HP:0030082)1.82600534
147Hypophosphatemic rickets (HP:0004912)1.82544678
148Hypoplastic pelvis (HP:0008839)1.81563667
149Upper limb muscle weakness (HP:0003484)1.81295572
150Spastic tetraplegia (HP:0002510)1.79473788
151Akinesia (HP:0002304)1.78207486
152Cerebral hypomyelination (HP:0006808)1.77202293
153Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75201700
154Overfolded helix (HP:0000396)1.74794403
155Bronchiectasis (HP:0002110)1.74517293
156Pheochromocytoma (HP:0002666)1.74366474
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73530996
158Oligodactyly (HP:0012165)1.72675063
159Focal dystonia (HP:0004373)1.72600765
160Aplasia/Hypoplasia of the spleen (HP:0010451)1.71492991
161Nasolacrimal duct obstruction (HP:0000579)1.70947830
162Hypoplasia of the ulna (HP:0003022)1.70079796
163Atelectasis (HP:0100750)1.68177374
164Partial duplication of the phalanx of hand (HP:0009999)1.67690597
165Abnormality of renal resorption (HP:0011038)1.66630060
166Cutaneous finger syndactyly (HP:0010554)1.65628543
167Ulnar claw (HP:0001178)1.64985506
168Delayed myelination (HP:0012448)1.60869190
169Metabolic alkalosis (HP:0200114)1.60443433
170Abnormality of the renal medulla (HP:0100957)1.58485173
171Hypothermia (HP:0002045)1.58103397
172Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.58041788
173Aplasia/Hypoplasia of the lens (HP:0008063)1.56822045
174Flat occiput (HP:0005469)1.56786326
175Intestinal atresia (HP:0011100)1.56400085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK22.90929292
2MAP3K42.90858865
3PHKG22.56230330
4PHKG12.56230330
5PINK12.55783299
6MAPK152.45213171
7TLK12.39761962
8STK392.32803643
9TNIK2.25835956
10CASK10.1875743
11PKN11.94562204
12PAK61.93632904
13DAPK21.89594839
14MUSK1.87668237
15INSRR1.82017440
16STK161.74978782
17GRK11.73052166
18MINK11.72256731
19BLK1.60397569
20OXSR11.59522523
21MKNK11.57895228
22PLK21.46268072
23IRAK11.38973150
24CAMKK11.35353882
25FRK1.34494821
26IRAK21.34072436
27PRKD31.32849204
28NTRK31.32240278
29GRK71.29673039
30BMPR1B1.26136473
31FES1.24583401
32MAP2K41.24066883
33UHMK11.22002005
34TSSK61.21034098
35PRKCG1.20986689
36CLK11.18784727
37MAPKAPK51.16845496
38ERBB31.13796352
39MAP3K11.09581659
40FGR1.09508137
41SGK21.08335150
42IRAK41.08128960
43NEK61.06384386
44TYRO31.04826340
45PNCK1.03194702
46FGFR21.02898084
47PAK31.01498358
48MAPK131.00420890
49CAMKK21.00058305
50CAMK2B0.98588299
51DYRK20.97877980
52MAP3K90.97071158
53ADRBK20.96129116
54PAK20.94518228
55CDK30.90315293
56WNK40.86975821
57PBK0.83243744
58MARK10.82200574
59EPHB10.82092482
60YES10.81031275
61SRPK10.80359814
62HIPK20.77830053
63EPHA40.77426066
64NTRK20.76512852
65CSNK1G10.75788287
66CDK190.75761362
67PRKCZ0.74778103
68SIK20.74605603
69PRKCE0.72616958
70PRKD20.71149492
71SGK10.70639002
72KSR10.70549255
73CAMK2A0.68781769
74VRK10.68750551
75MET0.67385455
76ROCK20.67017980
77CAMK2D0.65645827
78PRKG10.64980844
79MAP4K20.63959632
80CSNK1G30.63129069
81MST40.61277257
82CDK150.60966015
83CDK180.60928238
84CDK140.59908246
85MARK20.59494992
86STK380.58592289
87ARAF0.57918889
88PIK3CG0.57276836
89DYRK1A0.56865659
90NTRK10.56826047
91EIF2AK20.56357801
92KSR20.56192745
93CAMK40.55653764
94DYRK30.55540043
95CDK11A0.54560146
96RPS6KA30.54204951
97PRKAA20.54177860
98CSNK1A1L0.53273299
99NME10.52891886
100TRIM280.52369362
101WNK10.51703516
102FER0.50889538
103SGK30.49797306
104CDK50.49681533
105CCNB10.48387469
106DAPK30.47891230
107MAP2K20.47885690
108NLK0.47563957
109CAMK10.45329680
110CSNK1G20.45272037
111CAMK2G0.45102821
112BMPR20.44607799
113PRPF4B0.44362279
114BCR0.44006779
115PRKD10.43791354
116LIMK10.42964331
117AKT30.41799556
118STK38L0.40923827
119RPS6KA50.40595481
120PRKCA0.40115787
121MAP2K70.40068896
122GSK3A0.39049520
123GRK50.36720042
124PRKACA0.35889947
125PRKCH0.35817399
126PAK10.34409940
127STK110.33988530
128ERBB20.33899491
129RET0.33246762
130DAPK10.33165463
131FYN0.31620519
132CSNK1D0.31590578
133DYRK1B0.31570391
134PRKCB0.31264586
135ACVR1B0.30962293
136TNK20.30087868
137MAP3K50.29827538
138ADRBK10.29616481
139PRKCQ0.28534518
140IRAK30.28011084
141EPHA30.25769089
142TAOK30.25231413
143SGK4940.25200777
144SGK2230.25200777
145WNK30.23983150
146CSNK1A10.23960852
147DMPK0.22689270
148MAPK100.22616312
149ERBB40.22030902

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.64327136
2Phototransduction_Homo sapiens_hsa047442.86214881
3Sphingolipid metabolism_Homo sapiens_hsa006002.31130056
4Nicotine addiction_Homo sapiens_hsa050332.30868777
5Fatty acid elongation_Homo sapiens_hsa000622.28922915
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.23001347
7Ether lipid metabolism_Homo sapiens_hsa005652.17351430
8Oxidative phosphorylation_Homo sapiens_hsa001902.12335543
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01658527
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94618262
11Axon guidance_Homo sapiens_hsa043601.93236843
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90653730
13Serotonergic synapse_Homo sapiens_hsa047261.90366084
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.82813093
15Long-term depression_Homo sapiens_hsa047301.80313312
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76777805
17Taste transduction_Homo sapiens_hsa047421.72552095
18Glutamatergic synapse_Homo sapiens_hsa047241.72365229
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68609687
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65947271
21Morphine addiction_Homo sapiens_hsa050321.64614545
22Cocaine addiction_Homo sapiens_hsa050301.57414208
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57126246
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54476035
25Ribosome_Homo sapiens_hsa030101.50706961
26Linoleic acid metabolism_Homo sapiens_hsa005911.49284226
27GABAergic synapse_Homo sapiens_hsa047271.45271142
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44722510
29Alzheimers disease_Homo sapiens_hsa050101.33707923
30Parkinsons disease_Homo sapiens_hsa050121.32168888
31Arachidonic acid metabolism_Homo sapiens_hsa005901.30225294
32Other glycan degradation_Homo sapiens_hsa005111.28386775
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25324010
34Fanconi anemia pathway_Homo sapiens_hsa034601.24617734
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21544936
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14911766
37Vibrio cholerae infection_Homo sapiens_hsa051101.14199946
38Sulfur metabolism_Homo sapiens_hsa009201.11612839
39Circadian entrainment_Homo sapiens_hsa047131.11198571
40Calcium signaling pathway_Homo sapiens_hsa040201.10506815
41Insulin secretion_Homo sapiens_hsa049111.09533608
42beta-Alanine metabolism_Homo sapiens_hsa004101.08302146
43Butanoate metabolism_Homo sapiens_hsa006501.08170481
44Bile secretion_Homo sapiens_hsa049761.06169651
45Salivary secretion_Homo sapiens_hsa049701.05955924
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.04091972
47Melanogenesis_Homo sapiens_hsa049161.03916742
48Amphetamine addiction_Homo sapiens_hsa050311.02318302
49Cardiac muscle contraction_Homo sapiens_hsa042601.01707809
50Renin secretion_Homo sapiens_hsa049240.97432729
51Hedgehog signaling pathway_Homo sapiens_hsa043400.96041469
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93001655
53Autoimmune thyroid disease_Homo sapiens_hsa053200.92608421
54Histidine metabolism_Homo sapiens_hsa003400.92508181
55Steroid biosynthesis_Homo sapiens_hsa001000.92295387
56Ras signaling pathway_Homo sapiens_hsa040140.90966428
57Huntingtons disease_Homo sapiens_hsa050160.90575237
58Arginine and proline metabolism_Homo sapiens_hsa003300.89855406
59Estrogen signaling pathway_Homo sapiens_hsa049150.89192644
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88783382
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88051341
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.86171786
63Asthma_Homo sapiens_hsa053100.84683322
64Oocyte meiosis_Homo sapiens_hsa041140.84253004
65ABC transporters_Homo sapiens_hsa020100.83439394
66Collecting duct acid secretion_Homo sapiens_hsa049660.81755283
67Cholinergic synapse_Homo sapiens_hsa047250.78241262
68Wnt signaling pathway_Homo sapiens_hsa043100.77957371
69Thyroid hormone synthesis_Homo sapiens_hsa049180.77471252
70Pancreatic secretion_Homo sapiens_hsa049720.77032229
71Nitrogen metabolism_Homo sapiens_hsa009100.74356729
72ErbB signaling pathway_Homo sapiens_hsa040120.74254124
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74234124
74Dopaminergic synapse_Homo sapiens_hsa047280.74128863
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73297582
76Gap junction_Homo sapiens_hsa045400.72320956
77Ovarian steroidogenesis_Homo sapiens_hsa049130.72198154
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71920992
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70689614
80Rheumatoid arthritis_Homo sapiens_hsa053230.70503406
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70498696
82GnRH signaling pathway_Homo sapiens_hsa049120.68414543
83Regulation of autophagy_Homo sapiens_hsa041400.68024686
84cAMP signaling pathway_Homo sapiens_hsa040240.67013938
85Olfactory transduction_Homo sapiens_hsa047400.66378224
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66368374
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64391865
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63040372
89Basal cell carcinoma_Homo sapiens_hsa052170.61822727
90Gastric acid secretion_Homo sapiens_hsa049710.61644054
91Renal cell carcinoma_Homo sapiens_hsa052110.60811323
92Arginine biosynthesis_Homo sapiens_hsa002200.59834329
93MAPK signaling pathway_Homo sapiens_hsa040100.59802614
94Vitamin B6 metabolism_Homo sapiens_hsa007500.59404828
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58428635
96Alcoholism_Homo sapiens_hsa050340.56465028
97Type II diabetes mellitus_Homo sapiens_hsa049300.55907216
98Folate biosynthesis_Homo sapiens_hsa007900.53137877
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52980435
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.52609005
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.51949363
102Graft-versus-host disease_Homo sapiens_hsa053320.51810674
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50940895
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49754247
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49458043
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47243944
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46209286
108Circadian rhythm_Homo sapiens_hsa047100.46011939
109Retinol metabolism_Homo sapiens_hsa008300.45839287
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44412165
111Dorso-ventral axis formation_Homo sapiens_hsa043200.43845326
112Oxytocin signaling pathway_Homo sapiens_hsa049210.43747240
113Long-term potentiation_Homo sapiens_hsa047200.43347953
114Phagosome_Homo sapiens_hsa041450.42321868
115Rap1 signaling pathway_Homo sapiens_hsa040150.40012100
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39684879
117Inositol phosphate metabolism_Homo sapiens_hsa005620.39055072
118Prion diseases_Homo sapiens_hsa050200.38498828
119Propanoate metabolism_Homo sapiens_hsa006400.37806059
120Melanoma_Homo sapiens_hsa052180.36554001
121Vitamin digestion and absorption_Homo sapiens_hsa049770.36346004
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.36271419
123Phenylalanine metabolism_Homo sapiens_hsa003600.35612465
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35247199
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35116130
126Tight junction_Homo sapiens_hsa045300.34686850
127Basal transcription factors_Homo sapiens_hsa030220.34216198
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32427953
129Choline metabolism in cancer_Homo sapiens_hsa052310.32400659
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.32099217
131Synaptic vesicle cycle_Homo sapiens_hsa047210.32091929
132Peroxisome_Homo sapiens_hsa041460.30495233
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28290296
134Hippo signaling pathway_Homo sapiens_hsa043900.27788776
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.27709764

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