KLHL35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.56063895
2neuron remodeling (GO:0016322)7.05373885
3heparin biosynthetic process (GO:0030210)6.50244663
4heparin metabolic process (GO:0030202)6.50244663
5positive regulation of gastrulation (GO:2000543)5.68260096
6response to pheromone (GO:0019236)5.56365287
7urogenital system development (GO:0001655)5.47631209
8positive regulation of action potential (GO:0045760)5.34331694
9spinal cord association neuron differentiation (GO:0021527)5.23697064
10neuronal ion channel clustering (GO:0045161)5.19244761
11axonal fasciculation (GO:0007413)5.12886664
12positive regulation of mitochondrial membrane permeability (GO:0035794)5.07118772
13forebrain neuron differentiation (GO:0021879)4.92122259
14nucleobase catabolic process (GO:0046113)4.83127125
15embryonic retina morphogenesis in camera-type eye (GO:0060059)4.81128168
16presynaptic membrane organization (GO:0097090)4.76140073
17substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.66643497
18substrate-independent telencephalic tangential migration (GO:0021826)4.66643497
19sperm capacitation (GO:0048240)4.64363348
20myelination (GO:0042552)4.63312886
21ensheathment of neurons (GO:0007272)4.60883438
22axon ensheathment (GO:0008366)4.60883438
23head development (GO:0060322)4.34268958
24sodium ion export (GO:0071436)4.22993340
25negative regulation of osteoblast proliferation (GO:0033689)4.18906484
26epithelial cilium movement (GO:0003351)4.18675882
27negative regulation of neurotransmitter secretion (GO:0046929)4.14459005
28cerebellum development (GO:0021549)4.01264185
29acrosome reaction (GO:0007340)3.95753074
30neuron recognition (GO:0008038)3.92687146
31uterus development (GO:0060065)3.87000222
32heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.84784033
33negative regulation of calcium ion transport into cytosol (GO:0010523)3.77329039
34thalamus development (GO:0021794)3.72907735
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69778987
36synaptic transmission, cholinergic (GO:0007271)3.69200170
37positive regulation of cell cycle checkpoint (GO:1901978)3.68427124
38forebrain neuron development (GO:0021884)3.67733202
39neurotransmitter catabolic process (GO:0042135)3.63386205
40protein polyglutamylation (GO:0018095)3.58299254
41amyloid precursor protein catabolic process (GO:0042987)3.57893872
42mannosylation (GO:0097502)3.57000876
43retinal ganglion cell axon guidance (GO:0031290)3.56870548
44somite rostral/caudal axis specification (GO:0032525)3.55591880
45retina layer formation (GO:0010842)3.54464316
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54055521
47regulation of synapse structural plasticity (GO:0051823)3.53025575
48cornea development in camera-type eye (GO:0061303)3.48488050
49post-anal tail morphogenesis (GO:0036342)3.46987857
50pyrimidine nucleobase catabolic process (GO:0006208)3.45322834
51modulation by virus of host process (GO:0019054)3.44527124
52neurofilament cytoskeleton organization (GO:0060052)3.43084350
53cilium movement (GO:0003341)3.40695289
54cell differentiation in spinal cord (GO:0021515)3.40170864
55pattern specification involved in kidney development (GO:0061004)3.36895359
56nerve growth factor signaling pathway (GO:0038180)3.34430547
57cell migration in hindbrain (GO:0021535)3.33631010
58amyloid precursor protein metabolic process (GO:0042982)3.32246804
59establishment of mitochondrion localization (GO:0051654)3.31889055
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.30877048
61positive regulation of protein homooligomerization (GO:0032464)3.29769792
62response to acidic pH (GO:0010447)3.28975059
63cell proliferation in forebrain (GO:0021846)3.28928037
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.27975235
65regulation of translation, ncRNA-mediated (GO:0045974)3.27975235
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27975235
67endoderm formation (GO:0001706)3.26075986
68regulation of mitochondrial membrane permeability (GO:0046902)3.25757414
69auditory behavior (GO:0031223)3.25053190
70peptidyl-tyrosine autophosphorylation (GO:0038083)3.24114512
71peptidyl-arginine omega-N-methylation (GO:0035247)3.20734698
72adult walking behavior (GO:0007628)3.20449472
73transmission of nerve impulse (GO:0019226)3.18125995
74response to methylmercury (GO:0051597)3.16689650
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14988149
76regulation of cilium movement (GO:0003352)3.14447007
77regulation of membrane permeability (GO:0090559)3.10900349
78positive regulation of RNA splicing (GO:0033120)3.09273327
79glomerulus development (GO:0032835)3.06597237
80negative regulation of axon guidance (GO:1902668)3.06300255
81ganglion development (GO:0061548)3.03468138
82behavioral response to ethanol (GO:0048149)3.03023686
83bone trabecula formation (GO:0060346)3.01669678
84regulation of astrocyte differentiation (GO:0048710)3.01551009
85barbed-end actin filament capping (GO:0051016)3.01422819
86central nervous system neuron development (GO:0021954)3.00909723
87primitive streak formation (GO:0090009)3.00379023
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.99842238
89NADH dehydrogenase complex assembly (GO:0010257)2.99842238
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99842238
91peptidyl-arginine N-methylation (GO:0035246)2.99703908
92peptidyl-arginine methylation (GO:0018216)2.99703908
93postsynaptic membrane organization (GO:0001941)2.97821999
94positive regulation of microtubule polymerization (GO:0031116)2.97548770
95regulation of B cell receptor signaling pathway (GO:0050855)2.97013245
96hyaluronan catabolic process (GO:0030214)2.96272650
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95382703
98semaphorin-plexin signaling pathway (GO:0071526)2.94948848
99regulation of neuron migration (GO:2001222)2.94730645
100magnesium ion transport (GO:0015693)2.93180552
101embryonic body morphogenesis (GO:0010172)2.92675911
102negative regulation of neurotransmitter transport (GO:0051589)2.90308677
103neuron maturation (GO:0042551)2.88354234
104cerebellar granule cell differentiation (GO:0021707)2.88348250
105ear development (GO:0043583)2.87605679
106synapse assembly (GO:0007416)2.84695778
107tachykinin receptor signaling pathway (GO:0007217)2.82788438
108cerebellar Purkinje cell differentiation (GO:0021702)2.81988980
109nonmotile primary cilium assembly (GO:0035058)2.81775006
110iron-sulfur cluster assembly (GO:0016226)2.80408484
111metallo-sulfur cluster assembly (GO:0031163)2.80408484
112regulation of microtubule-based movement (GO:0060632)2.80358522
113telencephalon development (GO:0021537)2.79678848
114negative regulation of macroautophagy (GO:0016242)2.78449417
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.77839408
116parturition (GO:0007567)2.77813300
117lung epithelium development (GO:0060428)2.77446658
118cranial nerve structural organization (GO:0021604)2.76877643
119peristalsis (GO:0030432)2.76866274
120lens fiber cell development (GO:0070307)2.76771779
121modulation by virus of host morphology or physiology (GO:0019048)2.76511435
122nitrogen cycle metabolic process (GO:0071941)2.75874040
123body morphogenesis (GO:0010171)2.74878022
124negative regulation of response to food (GO:0032096)2.74737747
125negative regulation of appetite (GO:0032099)2.74737747
126detection of light stimulus involved in visual perception (GO:0050908)2.73749060
127detection of light stimulus involved in sensory perception (GO:0050962)2.73749060
128neuromuscular synaptic transmission (GO:0007274)2.73657693
129neuron cell-cell adhesion (GO:0007158)2.72631185
130epithelial cell fate commitment (GO:0072148)2.72611587
131positive regulation of male gonad development (GO:2000020)2.72590794
132protein kinase C signaling (GO:0070528)2.72464360
133long-chain fatty acid biosynthetic process (GO:0042759)2.71984427
134gamma-aminobutyric acid transport (GO:0015812)2.71799948
135motor neuron axon guidance (GO:0008045)2.68884671
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.68584156
137neuron migration (GO:0001764)2.67951325
138L-fucose catabolic process (GO:0042355)2.67220390
139fucose catabolic process (GO:0019317)2.67220390
140L-fucose metabolic process (GO:0042354)2.67220390
141proteoglycan biosynthetic process (GO:0030166)2.66852533
142mechanosensory behavior (GO:0007638)2.65674252
143spinal cord development (GO:0021510)2.65158943
144modulation by symbiont of host cellular process (GO:0044068)2.63518290
145neuron fate specification (GO:0048665)2.62984583
146histone arginine methylation (GO:0034969)2.62790836
147glucosamine-containing compound catabolic process (GO:1901072)2.62188517
148establishment of protein localization to mitochondrial membrane (GO:0090151)2.61903413
149locomotory exploration behavior (GO:0035641)2.61501169
150response to lipoprotein particle (GO:0055094)2.61435712
151regulation of ARF GTPase activity (GO:0032312)2.61119814
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59520603
153oligodendrocyte differentiation (GO:0048709)2.58511050
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56785316
155central nervous system neuron differentiation (GO:0021953)2.55950331
156protein localization to synapse (GO:0035418)2.55903307
157regulation of action potential (GO:0098900)2.55675419
158regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54979621
159axonemal dynein complex assembly (GO:0070286)2.54962872
160ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.54946607
161membrane repolarization (GO:0086009)2.54305987
162central nervous system projection neuron axonogenesis (GO:0021952)2.54084375
163myelin maintenance (GO:0043217)2.54055078
164regulation of collateral sprouting (GO:0048670)2.53911166
165negative regulation of transcription by competitive promoter binding (GO:0010944)2.53575354
166prenylation (GO:0097354)2.52651930
167protein prenylation (GO:0018342)2.52651930
168membrane repolarization during action potential (GO:0086011)2.52463490
169synaptic transmission, dopaminergic (GO:0001963)2.52358164
170protein palmitoylation (GO:0018345)2.49635480
171negative regulation of axonogenesis (GO:0050771)2.49405440
172myeloid cell homeostasis (GO:0002262)2.49224576
173cell differentiation in hindbrain (GO:0021533)2.49084642
174centrosome duplication (GO:0051298)2.48959935
175cellular response to nerve growth factor stimulus (GO:1990090)2.48007374
176response to nerve growth factor (GO:1990089)2.48007374
177dendritic spine morphogenesis (GO:0060997)2.47638127
178negative regulation of JAK-STAT cascade (GO:0046426)2.47455084
179positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.47321013
180regulation of somitogenesis (GO:0014807)12.9385529
181central nervous system myelination (GO:0022010)10.3757122
182axon ensheathment in central nervous system (GO:0032291)10.3757122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.68108593
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.69155047
3AR_21572438_ChIP-Seq_LNCaP_Human3.04586687
4EZH2_22144423_ChIP-Seq_EOC_Human2.87684306
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.85345601
6REST_21632747_ChIP-Seq_MESCs_Mouse2.79082909
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77455287
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.75832334
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67831373
10VDR_21846776_ChIP-Seq_THP-1_Human2.65213123
11RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.51228361
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.44113907
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36622294
14ZNF274_21170338_ChIP-Seq_K562_Hela2.35469161
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31761777
16VDR_22108803_ChIP-Seq_LS180_Human2.30755546
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28493259
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.25776090
19IGF1R_20145208_ChIP-Seq_DFB_Human2.25577781
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.15112760
21EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12346649
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.11035630
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.10290436
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07550644
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00095390
26* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98490910
27VDR_24763502_ChIP-Seq_THP-1_Human1.97075416
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88917961
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88917961
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81273145
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80798260
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79977558
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79803532
34KDM2B_26808549_Chip-Seq_DND41_Human1.78559200
35OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.74482635
36STAT1_20625510_ChIP-Seq_HELA_Human1.74409333
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73386551
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.72984197
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.72665897
40ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72381997
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69488865
42KDM2B_26808549_Chip-Seq_K562_Human1.68067654
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66037534
44* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65706054
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64676065
46GBX2_23144817_ChIP-Seq_PC3_Human1.63718314
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62690014
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62534300
49RNF2_27304074_Chip-Seq_NSC_Mouse1.60319631
50* LXR_22292898_ChIP-Seq_THP-1_Human1.60141337
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59562126
52RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58580942
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.57668722
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57667007
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.57042122
56XRN2_22483619_ChIP-Seq_HELA_Human1.53599081
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53556308
58TCF7_22412390_ChIP-Seq_EML_Mouse1.51651258
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50751453
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50446784
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49990669
62PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47577634
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47435962
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47235304
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.47150300
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45966348
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45639510
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44435582
69IRF1_19129219_ChIP-ChIP_H3396_Human1.43560149
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.41338255
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38721115
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.38003574
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37681490
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36915090
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36143332
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36143332
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35914578
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.35604872
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34393054
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.34271106
81EWS_26573619_Chip-Seq_HEK293_Human1.32488447
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32251988
83TAF15_26573619_Chip-Seq_HEK293_Human1.30983769
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30291056
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.29854957
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29376724
87WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29237109
88RARB_27405468_Chip-Seq_BRAIN_Mouse1.28516797
89SCL_19346495_ChIP-Seq_HPC-7_Human1.27954303
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26806244
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24208060
92CTCF_27219007_Chip-Seq_Bcells_Human1.24191055
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23866665
94TP53_22573176_ChIP-Seq_HFKS_Human1.23270227
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19551153
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19367726
97SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19364155
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18841458
99SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18541152
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17431049
101UTX_26944678_Chip-Seq_JUKART_Human1.17058816
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16123700
103SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15165394
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14169983
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.13529417
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13284351
107FUS_26573619_Chip-Seq_HEK293_Human1.11180052
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10918168
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10721200
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10640454
111P300_19829295_ChIP-Seq_ESCs_Human1.08550023
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07888255
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07525036
114PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07370347
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06816993
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06298397
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06219508
118NCOR_22424771_ChIP-Seq_293T_Human1.06106273
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04740404
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.02772171
121CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02301911
122* MAF_26560356_Chip-Seq_TH1_Human1.02067786
123SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01160069
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00246759
125P68_20966046_ChIP-Seq_HELA_Human0.99432663
126E2F1_20622854_ChIP-Seq_HELA_Human0.99316748
127* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99158150
128AR_25329375_ChIP-Seq_VCAP_Human0.98713247
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98218520
130* MAF_26560356_Chip-Seq_TH2_Human0.97663313
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97408657
132CTCF_26484167_Chip-Seq_Bcells_Mouse0.95608772
133POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95461190
134TP63_19390658_ChIP-ChIP_HaCaT_Human0.95343323
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94187184
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93996212
137ER_23166858_ChIP-Seq_MCF-7_Human0.93348862
138SOX2_16153702_ChIP-ChIP_HESCs_Human0.93145693
139STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92655293
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92566493
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92219181
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92099573
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91873410
144PHF8_20622854_ChIP-Seq_HELA_Human0.91725991
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91720257
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91102422
147ERA_21632823_ChIP-Seq_H3396_Human0.89931686
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89869050
149DROSHA_22980978_ChIP-Seq_HELA_Human0.89863851
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89508439
151SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88620581
152FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87721044
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.87611173
154BCAT_22108803_ChIP-Seq_LS180_Human0.86460735
155SMAD4_21799915_ChIP-Seq_A2780_Human0.85759002
156WDR5_24793694_ChIP-Seq_LNCAP_Human0.84024736
157MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.83157762
158STAT3_23295773_ChIP-Seq_U87_Human0.83049697
159NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82593353
160SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82435631
161RUNX2_22187159_ChIP-Seq_PCA_Human0.82385192
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82268825
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80863360
164TAF2_19829295_ChIP-Seq_ESCs_Human0.80805121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous6.96043326
2MP0003880_abnormal_central_pattern4.75586369
3MP0005645_abnormal_hypothalamus_physiol3.64601217
4MP0004859_abnormal_synaptic_plasticity3.61683503
5MP0000566_synostosis3.51674408
6MP0003787_abnormal_imprinting3.20092601
7MP0000920_abnormal_myelination3.10256932
8MP0003183_abnormal_peptide_metabolism3.08893238
9MP0001188_hyperpigmentation3.08033789
10MP0000778_abnormal_nervous_system3.02866730
11MP0002653_abnormal_ependyma_morphology2.74486808
12MP0005410_abnormal_fertilization2.74439817
13MP0008961_abnormal_basal_metabolism2.72751686
14MP0006276_abnormal_autonomic_nervous2.64565290
15MP0008995_early_reproductive_senescence2.43667688
16MP0003890_abnormal_embryonic-extraembry2.29285343
17MP0010030_abnormal_orbit_morphology2.05161493
18MP0009046_muscle_twitch2.01519198
19MP0002822_catalepsy1.98329019
20MP0003136_yellow_coat_color1.93391903
21MP0002638_abnormal_pupillary_reflex1.90334584
22MP0002751_abnormal_autonomic_nervous1.89094742
23MP0008789_abnormal_olfactory_epithelium1.86926904
24MP0001968_abnormal_touch/_nociception1.86651647
25MP0002102_abnormal_ear_morphology1.80270198
26MP0001346_abnormal_lacrimal_gland1.79879024
27MP0001986_abnormal_taste_sensitivity1.68993377
28MP0002163_abnormal_gland_morphology1.67971571
29MP0005394_taste/olfaction_phenotype1.66767179
30MP0005499_abnormal_olfactory_system1.66767179
31MP0000955_abnormal_spinal_cord1.64269184
32MP0009384_cardiac_valve_regurgitation1.61576964
33MP0002557_abnormal_social/conspecific_i1.60061507
34MP0008569_lethality_at_weaning1.55381019
35MP0004270_analgesia1.54948092
36MP0005551_abnormal_eye_electrophysiolog1.54904278
37MP0004742_abnormal_vestibular_system1.53830493
38MP0003122_maternal_imprinting1.52191990
39MP0005360_urolithiasis1.51228127
40MP0001440_abnormal_grooming_behavior1.47116118
41MP0003011_delayed_dark_adaptation1.46049413
42MP0002882_abnormal_neuron_morphology1.42518998
43MP0002160_abnormal_reproductive_system1.41347951
44MP0009780_abnormal_chondrocyte_physiolo1.40900160
45MP0001529_abnormal_vocalization1.40133529
46MP0004134_abnormal_chest_morphology1.39942734
47MP0001485_abnormal_pinna_reflex1.37366948
48MP0002909_abnormal_adrenal_gland1.36977468
49MP0002064_seizures1.35293974
50MP0000631_abnormal_neuroendocrine_gland1.34346604
51MP0004885_abnormal_endolymph1.33881776
52MP0003634_abnormal_glial_cell1.33303504
53MP0008877_abnormal_DNA_methylation1.32480719
54MP0003329_amyloid_beta_deposits1.31942181
55MP0003635_abnormal_synaptic_transmissio1.31542384
56MP0002735_abnormal_chemical_nociception1.31297262
57MP0008260_abnormal_autophagy1.29181979
58MP0006072_abnormal_retinal_apoptosis1.27164987
59MP0000003_abnormal_adipose_tissue1.26227045
60MP0000538_abnormal_urinary_bladder1.26113863
61MP0003172_abnormal_lysosome_physiology1.25585733
62MP0004510_myositis1.23147827
63MP0004811_abnormal_neuron_physiology1.22564802
64MP0001970_abnormal_pain_threshold1.22260298
65MP0005310_abnormal_salivary_gland1.19921035
66MP0002152_abnormal_brain_morphology1.16873667
67MP0002272_abnormal_nervous_system1.16759378
68MP0008770_decreased_survivor_rate1.15793997
69MP0001984_abnormal_olfaction1.15394444
70MP0003828_pulmonary_edema1.14987642
71MP0000685_abnormal_immune_system1.14549599
72MP0003698_abnormal_male_reproductive1.14314752
73MP0002067_abnormal_sensory_capabilities1.13900482
74MP0003879_abnormal_hair_cell1.13781239
75MP0002736_abnormal_nociception_after1.13483323
76MP0001661_extended_life_span1.13310552
77MP0002932_abnormal_joint_morphology1.12933218
78MP0002734_abnormal_mechanical_nocicepti1.12734214
79MP0005174_abnormal_tail_pigmentation1.12468472
80MP0001502_abnormal_circadian_rhythm1.12360738
81MP0002063_abnormal_learning/memory/cond1.09888405
82MP0004145_abnormal_muscle_electrophysio1.09280265
83MP0005257_abnormal_intraocular_pressure1.08984824
84MP0001486_abnormal_startle_reflex1.08879277
85MP0005083_abnormal_biliary_tract1.06785075
86MP0003646_muscle_fatigue1.06143492
87MP0002733_abnormal_thermal_nociception1.05927909
88MP0009379_abnormal_foot_pigmentation1.05132562
89MP0006082_CNS_inflammation1.03849774
90MP0003121_genomic_imprinting1.03141706
91MP0000569_abnormal_digit_pigmentation1.02515481
92MP0005195_abnormal_posterior_eye1.01603584
93MP0005253_abnormal_eye_physiology1.00439092
94MP0005171_absent_coat_pigmentation1.00358085
95MP0005084_abnormal_gallbladder_morpholo0.99509902
96MP0001348_abnormal_lacrimal_gland0.99042250
97MP0003091_abnormal_cell_migration0.98410227
98MP0002184_abnormal_innervation0.97674265
99MP0002752_abnormal_somatic_nervous0.97644849
100MP0003861_abnormal_nervous_system0.96760760
101MP0001905_abnormal_dopamine_level0.96619130
102MP0002066_abnormal_motor_capabilities/c0.96177865
103MP0002876_abnormal_thyroid_physiology0.95634437
104MP0001929_abnormal_gametogenesis0.94998657
105MP0004133_heterotaxia0.94688582
106MP0002138_abnormal_hepatobiliary_system0.94399291
107MP0000383_abnormal_hair_follicle0.92093262
108MP0002928_abnormal_bile_duct0.90309780
109MP0003303_peritoneal_inflammation0.89931893
110MP0001286_abnormal_eye_development0.89443401
111MP0002837_dystrophic_cardiac_calcinosis0.89253350
112MP0005389_reproductive_system_phenotype0.87249168
113MP0003315_abnormal_perineum_morphology0.86615962
114MP0005379_endocrine/exocrine_gland_phen0.85368501
115MP0003942_abnormal_urinary_system0.85057365
116MP0003123_paternal_imprinting0.84822012
117MP0004142_abnormal_muscle_tone0.84014344
118MP0005000_abnormal_immune_tolerance0.83620215
119MP0002229_neurodegeneration0.83164151
120MP0010386_abnormal_urinary_bladder0.82932581
121MP0002210_abnormal_sex_determination0.82727320
122MP0002081_perinatal_lethality0.82165823
123MP0001324_abnormal_eye_pigmentation0.81798779
124MP0005646_abnormal_pituitary_gland0.81543289
125MP0000534_abnormal_ureter_morphology0.81372779
126MP0003938_abnormal_ear_development0.81317003
127MP0000462_abnormal_digestive_system0.80235292
128MP0005375_adipose_tissue_phenotype0.79437938
129MP0004085_abnormal_heartbeat0.78886462
130MP0005381_digestive/alimentary_phenotyp0.78778375
131MP0001299_abnormal_eye_distance/0.76994571
132MP0003385_abnormal_body_wall0.76991927
133MP0003119_abnormal_digestive_system0.76783696
134MP0004185_abnormal_adipocyte_glucose0.76630296
135MP0006292_abnormal_olfactory_placode0.76623356
136MP0002161_abnormal_fertility/fecundity0.76456847
137MP0001963_abnormal_hearing_physiology0.75258759
138MP0003632_abnormal_nervous_system0.73577463
139MP0003137_abnormal_impulse_conducting0.73401434
140MP0005197_abnormal_uvea_morphology0.73353558
141MP0002938_white_spotting0.70924727
142MP0005623_abnormal_meninges_morphology0.70489794
143MP0000026_abnormal_inner_ear0.70432695
144MP0010769_abnormal_survival0.69875084
145MP0000604_amyloidosis0.69114614
146MP0010768_mortality/aging0.67657242
147MP0002114_abnormal_axial_skeleton0.66219224
148MP0002111_abnormal_tail_morphology0.66049630
149MP0002069_abnormal_eating/drinking_beha0.65521466
150MP0001943_abnormal_respiration0.64772347
151MP0000049_abnormal_middle_ear0.64008174
152MP0009745_abnormal_behavioral_response0.63889944
153MP0002572_abnormal_emotion/affect_behav0.63635841
154MP0000465_gastrointestinal_hemorrhage0.63343084
155MP0001873_stomach_inflammation0.62800342
156MP0010770_preweaning_lethality0.61197996
157MP0002082_postnatal_lethality0.61197996

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pulmonary veins (HP:0011718)9.83713580
2Abnormal pancreas size (HP:0012094)5.68969933
3Myelomeningocele (HP:0002475)5.14107494
4Pseudobulbar signs (HP:0002200)4.89099128
5Abnormality of the intervertebral disk (HP:0005108)4.43447018
6Hepatocellular necrosis (HP:0001404)4.26940782
7Abnormality of the odontoid process (HP:0003310)3.90717172
8Rib fusion (HP:0000902)3.83504525
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.77267033
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.77267033
11Abnormality of midbrain morphology (HP:0002418)3.71504661
12Molar tooth sign on MRI (HP:0002419)3.71504661
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.69423385
14Supranuclear gaze palsy (HP:0000605)3.64407456
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.50946497
16Meningocele (HP:0002435)3.40735615
17Hemivertebrae (HP:0002937)3.34777158
18Shawl scrotum (HP:0000049)3.26258398
19Abnormality of the corticospinal tract (HP:0002492)3.22733063
20Neurofibrillary tangles (HP:0002185)3.21822007
21Neonatal respiratory distress (HP:0002643)3.21101850
22Pancreatic fibrosis (HP:0100732)3.18503705
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.17861521
24Pancreatic cysts (HP:0001737)3.16955530
25Hepatic necrosis (HP:0002605)3.12937278
26Sensory axonal neuropathy (HP:0003390)3.06818521
27Medial flaring of the eyebrow (HP:0010747)3.05881249
28Failure to thrive in infancy (HP:0001531)3.05834343
29Nephronophthisis (HP:0000090)3.04629486
30Abnormal eating behavior (HP:0100738)3.04104114
31High anterior hairline (HP:0009890)3.00952942
32Congenital stationary night blindness (HP:0007642)3.00036007
33Axonal loss (HP:0003447)2.93817835
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87154162
35Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87154162
36Vertebral fusion (HP:0002948)2.87147162
37True hermaphroditism (HP:0010459)2.81318238
38Decreased circulating renin level (HP:0003351)2.80573715
39Patellar aplasia (HP:0006443)2.73965651
40Hepatoblastoma (HP:0002884)2.72271719
41Neoplasm of the adrenal cortex (HP:0100641)2.71603672
42Neuronal loss in central nervous system (HP:0002529)2.70804867
43Spastic gait (HP:0002064)2.69700561
44Increased intramyocellular lipid droplets (HP:0012240)2.69366276
45Chorioretinal atrophy (HP:0000533)2.68924861
46Gait imbalance (HP:0002141)2.68199361
47Prominent occiput (HP:0000269)2.64105787
48Abnormality of the renal medulla (HP:0100957)2.63500345
49Aplasia/Hypoplasia of the patella (HP:0006498)2.57481619
50Anteriorly placed anus (HP:0001545)2.53216926
51Increased muscle lipid content (HP:0009058)2.53135184
52Lissencephaly (HP:0001339)2.52568680
53Chronic hepatic failure (HP:0100626)2.52462613
54Abnormality of the lower motor neuron (HP:0002366)2.51828344
55Pachygyria (HP:0001302)2.47769426
56Absent/shortened dynein arms (HP:0200106)2.47640377
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.47640377
58Progressive cerebellar ataxia (HP:0002073)2.45458735
59Abnormality of alanine metabolism (HP:0010916)2.45333547
60Hyperalaninemia (HP:0003348)2.45333547
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.45333547
62Diastasis recti (HP:0001540)2.45006213
63Congenital primary aphakia (HP:0007707)2.42952872
64Cerebral inclusion bodies (HP:0100314)2.42461136
65Nephrogenic diabetes insipidus (HP:0009806)2.41280186
66Loss of speech (HP:0002371)2.39223422
67Vaginal atresia (HP:0000148)2.38594958
68Spina bifida occulta (HP:0003298)2.37975557
69Genital tract atresia (HP:0001827)2.34690074
70Optic nerve coloboma (HP:0000588)2.33627801
71Type II lissencephaly (HP:0007260)2.32117175
72Severe visual impairment (HP:0001141)2.30494472
73Adrenal hypoplasia (HP:0000835)2.30335135
74Stridor (HP:0010307)2.28877291
75Coronal craniosynostosis (HP:0004440)2.28703803
76Rhabdomyolysis (HP:0003201)2.23881915
77Thickened helices (HP:0000391)2.23747048
78Cystic liver disease (HP:0006706)2.23495355
79Decreased central vision (HP:0007663)2.23093644
80Ulnar claw (HP:0001178)2.21800644
81Amaurosis fugax (HP:0100576)2.20639604
82Insomnia (HP:0100785)2.15292374
83Tubular atrophy (HP:0000092)2.14915007
84Abnormality of macular pigmentation (HP:0008002)2.13865062
85Polyphagia (HP:0002591)2.13864018
86Limb dystonia (HP:0002451)2.13650248
87Attenuation of retinal blood vessels (HP:0007843)2.12865879
88Increased hepatocellular lipid droplets (HP:0006565)2.12776783
89Pendular nystagmus (HP:0012043)2.12337961
90Anencephaly (HP:0002323)2.12156326
91Polydipsia (HP:0001959)2.11325106
92Abnormal drinking behavior (HP:0030082)2.11325106
93Neonatal hypoglycemia (HP:0001998)2.11041535
94Agitation (HP:0000713)2.10123315
95Overriding aorta (HP:0002623)2.09973950
96Upper motor neuron abnormality (HP:0002127)2.06559476
97Abnormal respiratory motile cilium physiology (HP:0012261)2.06545245
98Myokymia (HP:0002411)2.06229464
99Abnormality of the renal cortex (HP:0011035)2.03671431
100Alacrima (HP:0000522)2.03032675
101Metaphyseal dysplasia (HP:0100255)2.02938860
102Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02278139
103Hypoplasia of the brainstem (HP:0002365)2.02278139
104Drooling (HP:0002307)2.02107140
105Occipital encephalocele (HP:0002085)2.01701114
106Disproportionate short-trunk short stature (HP:0003521)2.00396656
107Anomalous pulmonary venous return (HP:0010772)11.2342638
108Abolished electroretinogram (ERG) (HP:0000550)1.99334370
109Optic nerve hypoplasia (HP:0000609)1.99304321
110Lipid accumulation in hepatocytes (HP:0006561)1.99093731
111Peripheral demyelination (HP:0011096)1.98970203
112Duplication of thumb phalanx (HP:0009942)1.98788611
113Plagiocephaly (HP:0001357)1.98359878
114Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98053994
115Spastic tetraplegia (HP:0002510)1.98032876
116Acute necrotizing encephalopathy (HP:0006965)1.96418746
117Concave nail (HP:0001598)1.96335468
118Abnormal respiratory motile cilium morphology (HP:0005938)1.96143854
119Abnormal respiratory epithelium morphology (HP:0012253)1.96143854
120Choroideremia (HP:0001139)1.95937772
121Large eyes (HP:0001090)1.95795783
122Sclerocornea (HP:0000647)1.94349783
123Broad-based gait (HP:0002136)1.94232280
124Growth hormone deficiency (HP:0000824)1.92340180
125Abnormal rod and cone electroretinograms (HP:0008323)1.91437158
126Abnormal protein glycosylation (HP:0012346)1.90753971
127Abnormal glycosylation (HP:0012345)1.90753971
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90753971
129Abnormal protein N-linked glycosylation (HP:0012347)1.90753971
130Focal seizures (HP:0007359)1.90449906
131Congenital hepatic fibrosis (HP:0002612)1.90380558
132Inability to walk (HP:0002540)1.89712243
133Hypophosphatemic rickets (HP:0004912)1.89506191
134Onion bulb formation (HP:0003383)1.88367895
135Focal motor seizures (HP:0011153)1.88177947
136Dandy-Walker malformation (HP:0001305)1.87842431
137Severe muscular hypotonia (HP:0006829)1.87563771
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87466675
139Poor coordination (HP:0002370)1.86722910
140Esotropia (HP:0000565)1.86416424
141Urinary urgency (HP:0000012)1.86176864
142Oligodactyly (hands) (HP:0001180)1.86157747
143Cerebellar dysplasia (HP:0007033)1.84827945
144Emotional lability (HP:0000712)1.84670478
145Progressive external ophthalmoplegia (HP:0000590)1.84606928
146Asplenia (HP:0001746)1.84296834
147Increased CSF lactate (HP:0002490)1.83399028
148Postural tremor (HP:0002174)1.82973364
149Gonadal dysgenesis (HP:0000133)1.82643983
150Sleep apnea (HP:0010535)1.82308323
151Absent thumb (HP:0009777)1.81624145
152Retinal dysplasia (HP:0007973)1.81464948
153Slow saccadic eye movements (HP:0000514)1.80148145
154Reticulocytopenia (HP:0001896)1.79954677
155Abnormal biliary tract physiology (HP:0012439)1.79947145
156Bile duct proliferation (HP:0001408)1.79947145
157Optic disc pallor (HP:0000543)1.79802282
158Myoglobinuria (HP:0002913)1.79707791
159Anophthalmia (HP:0000528)1.78298289
160Bony spicule pigmentary retinopathy (HP:0007737)1.78231447
161Excessive salivation (HP:0003781)1.78068959
162Intention tremor (HP:0002080)1.77256850
163Renal Fanconi syndrome (HP:0001994)1.77129046
164Narrow forehead (HP:0000341)1.77000704
165Amblyopia (HP:0000646)1.76487021
166Megalencephaly (HP:0001355)1.75526590
167Absent speech (HP:0001344)1.74105757
168Metabolic alkalosis (HP:0200114)1.73621516
169Mixed hearing impairment (HP:0000410)1.72926967
170Renal dysplasia (HP:0000110)1.72850119
171J-shaped sella turcica (HP:0002680)1.72730617
172Abnormality of the lumbar spine (HP:0100712)1.72673305
173Epileptic encephalopathy (HP:0200134)1.72512250
174Thyroid-stimulating hormone excess (HP:0002925)1.72446154
175Fetal akinesia sequence (HP:0001989)1.72135423
176Mitochondrial inheritance (HP:0001427)1.69856751
177Recurrent skin infections (HP:0001581)1.69682953
178Partial duplication of thumb phalanx (HP:0009944)1.69231739
179Heterotopia (HP:0002282)1.64622056
180Scanning speech (HP:0002168)1.64160285
181Elfin facies (HP:0004428)1.63983520
182Stomatitis (HP:0010280)1.63067187
183Decreased lacrimation (HP:0000633)1.62430515
184Aplasia/Hypoplasia of the spleen (HP:0010451)1.62224381
185Urinary incontinence (HP:0000020)1.61711575
186Aplasia involving bones of the extremities (HP:0009825)1.61680554
187Aplasia involving bones of the upper limbs (HP:0009823)1.61680554
188Aplasia of the phalanges of the hand (HP:0009802)1.61680554
189Progressive inability to walk (HP:0002505)1.59708785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD46.00447209
2CDK125.90480432
3EPHA34.60954957
4TLK14.32102219
5ADRBK23.39848606
6CASK3.38902655
7PINK13.06779008
8MAP3K92.78619875
9FRK2.77654361
10ICK2.66869021
11TESK22.43370868
12MAP3K42.18746666
13WNK32.00893967
14MAPK131.92306710
15GRK11.86182016
16MINK11.76154822
17BMPR1B1.71170790
18CDK191.67754812
19DYRK21.63606241
20PKN11.60379058
21PRKCG1.59461695
22CDK91.58773222
23STK161.51753273
24EPHB21.49725088
25BCKDK1.48139310
26STK391.47361150
27IRAK21.44059224
28PAK61.37124643
29DYRK31.36019626
30ROCK21.36017987
31ADRBK11.35827840
32MARK11.30512167
33ITK1.29088733
34MARK31.28449387
35ARAF1.27654426
36FGFR21.25494274
37UHMK11.23654990
38INSRR1.21617419
39MARK21.21248851
40KSR21.20976763
41LIMK11.19937126
42RAF11.14878746
43IRAK11.14132324
44DAPK21.10914986
45IRAK31.10515012
46MAP4K21.10084135
47MAP2K41.09234647
48PIM21.09171167
49TESK11.05462088
50DYRK1B1.04437106
51RPS6KA21.03010989
52TRIM281.00997374
53BCR0.99105450
54CDK80.98236350
55CSNK1A1L0.97633493
56PRPF4B0.94375107
57CSNK1G30.93878489
58IRAK40.91553711
59OXSR10.89701551
60MAP3K130.88901972
61PNCK0.88720303
62EPHB10.88655932
63KSR10.88624689
64NUAK10.87572062
65DYRK1A0.86931700
66ACVR1B0.86733426
67FES0.82156369
68HIPK20.80472345
69PRKCH0.77803240
70PRKCI0.75710268
71RPS6KL10.75299475
72RPS6KC10.75299475
73MUSK0.74392404
74SGK20.74354979
75ERBB20.74162364
76CHUK0.72868300
77TYRO30.72453107
78CAMKK20.70893478
79STK100.70719740
80NTRK20.68370971
81BUB10.67797653
82TEC0.66580184
83CAMK1D0.63153224
84BTK0.63108071
85PRKACA0.62660785
86PRKCZ0.61816491
87MAP3K60.61755613
88RPS6KA60.59680246
89SIK20.58937909
90PHKG20.58717112
91PHKG10.58717112
92CAMK10.58639521
93DAPK30.57794344
94CSNK1G20.57533450
95PRKCQ0.57351822
96FGFR30.57256078
97PRKCE0.57229557
98WNK40.56197514
99GRK50.55583168
100MTOR0.54882145
101CAMK1G0.54853786
102MKNK10.52799284
103CSNK1G10.52624881
104RPS6KA50.52311068
105ZAK0.52287978
106ROCK10.51062739
107CAMK2B0.50752107
108TNIK0.50010462
109ALK0.49929995
110CSNK1E0.49592052
111SGK4940.49292333
112SGK2230.49292333
113CAMKK10.48416373
114STK110.48012129
115MAPK90.47467038
116PAK30.46545335
117STK40.46489392
118NTRK10.45932224
119FGFR10.45681167
120TAOK10.44672997
121GRK60.44554149
122CAMK2A0.42000925
123MAP2K20.41619165
124NTRK30.41308414
125MAPK150.40587618
126CDK70.38984736
127PRKD30.38636584
128TAOK30.38203078
129CDK50.38182972
130NEK20.37786800
131CSNK1D0.37720640
132PLK20.37687366
133PRKAA10.37345252
134CSNK1A10.37108389
135BRAF0.37082923
136CSF1R0.36715191
137WNK10.36529053
138HCK0.35904518
139NEK60.35761568
140MKNK20.35628762
141MAP2K70.35468735
142PRKD10.35259762
143ZAP700.35021676
144PIM10.34768194
145AURKA0.33841726
146MAPKAPK50.33696252
147MAP3K100.33593811
148KIT0.33548050
149IKBKB0.33325027
150MAP3K110.32486994
151RPS6KA10.31564813
152EPHA40.29911958
153SRPK10.28892071

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005344.03964810
2Axon guidance_Homo sapiens_hsa043603.95872699
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.64793029
4Systemic lupus erythematosus_Homo sapiens_hsa053223.30623279
5Nicotine addiction_Homo sapiens_hsa050333.30549556
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.08105602
7Phototransduction_Homo sapiens_hsa047442.89955899
8Oxidative phosphorylation_Homo sapiens_hsa001902.86078014
9Alcoholism_Homo sapiens_hsa050342.34115939
10Notch signaling pathway_Homo sapiens_hsa043302.13162842
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08750374
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05908915
13Basal transcription factors_Homo sapiens_hsa030222.02099921
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97193878
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93059219
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91727529
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87772309
18Folate biosynthesis_Homo sapiens_hsa007901.80092168
19Insulin secretion_Homo sapiens_hsa049111.76920422
20Dorso-ventral axis formation_Homo sapiens_hsa043201.75604851
21Non-homologous end-joining_Homo sapiens_hsa034501.73697710
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72533971
23RNA polymerase_Homo sapiens_hsa030201.71204908
24Ether lipid metabolism_Homo sapiens_hsa005651.68430656
25Sphingolipid metabolism_Homo sapiens_hsa006001.58794229
26Steroid biosynthesis_Homo sapiens_hsa001001.57583526
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53320439
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.50484111
29Linoleic acid metabolism_Homo sapiens_hsa005911.48467601
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41448176
31Synaptic vesicle cycle_Homo sapiens_hsa047211.39910474
32Selenocompound metabolism_Homo sapiens_hsa004501.38078353
33Taste transduction_Homo sapiens_hsa047421.34127229
34Cholinergic synapse_Homo sapiens_hsa047251.32514152
35Basal cell carcinoma_Homo sapiens_hsa052171.32107139
36Butanoate metabolism_Homo sapiens_hsa006501.29552126
37Apoptosis_Homo sapiens_hsa042101.29394830
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27852727
39T cell receptor signaling pathway_Homo sapiens_hsa046601.27703455
40N-Glycan biosynthesis_Homo sapiens_hsa005101.23188968
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22964639
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16825145
43Sulfur relay system_Homo sapiens_hsa041221.15766395
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10594707
45Olfactory transduction_Homo sapiens_hsa047401.10534661
46Collecting duct acid secretion_Homo sapiens_hsa049661.10528206
47Colorectal cancer_Homo sapiens_hsa052101.09050697
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08269863
49B cell receptor signaling pathway_Homo sapiens_hsa046621.07773507
50Peroxisome_Homo sapiens_hsa041461.03745628
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.96173184
52Cocaine addiction_Homo sapiens_hsa050300.95914603
53Glutamatergic synapse_Homo sapiens_hsa047240.94444389
54Bladder cancer_Homo sapiens_hsa052190.93507349
55Nitrogen metabolism_Homo sapiens_hsa009100.93393493
56Protein export_Homo sapiens_hsa030600.93331237
57Hedgehog signaling pathway_Homo sapiens_hsa043400.91892321
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90524379
59Regulation of autophagy_Homo sapiens_hsa041400.88348289
60ErbB signaling pathway_Homo sapiens_hsa040120.87914581
61MicroRNAs in cancer_Homo sapiens_hsa052060.87516836
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84876685
63Ras signaling pathway_Homo sapiens_hsa040140.83498807
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.81409375
65Endocytosis_Homo sapiens_hsa041440.80896916
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80039645
67Renal cell carcinoma_Homo sapiens_hsa052110.79624013
68Gastric acid secretion_Homo sapiens_hsa049710.79324792
69Fatty acid elongation_Homo sapiens_hsa000620.78808373
70MAPK signaling pathway_Homo sapiens_hsa040100.73814747
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73636759
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71408066
73Calcium signaling pathway_Homo sapiens_hsa040200.71258165
74Ovarian steroidogenesis_Homo sapiens_hsa049130.70595033
75VEGF signaling pathway_Homo sapiens_hsa043700.68262696
76ABC transporters_Homo sapiens_hsa020100.68067901
77Tryptophan metabolism_Homo sapiens_hsa003800.67950338
78Alzheimers disease_Homo sapiens_hsa050100.66297783
79Viral carcinogenesis_Homo sapiens_hsa052030.66291451
80cAMP signaling pathway_Homo sapiens_hsa040240.65667043
81Circadian rhythm_Homo sapiens_hsa047100.65657140
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.65599700
83Serotonergic synapse_Homo sapiens_hsa047260.65205546
84Osteoclast differentiation_Homo sapiens_hsa043800.64504990
85Long-term depression_Homo sapiens_hsa047300.64346827
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63846338
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.63650270
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.63203191
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.63187925
90Herpes simplex infection_Homo sapiens_hsa051680.62781708
91Fanconi anemia pathway_Homo sapiens_hsa034600.62391705
92Pertussis_Homo sapiens_hsa051330.62232201
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62179811
94Choline metabolism in cancer_Homo sapiens_hsa052310.62008542
95Chronic myeloid leukemia_Homo sapiens_hsa052200.61475615
96Type II diabetes mellitus_Homo sapiens_hsa049300.56792956
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55513957
98Hippo signaling pathway_Homo sapiens_hsa043900.54415095
99Prion diseases_Homo sapiens_hsa050200.53933110
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53698019
101Gap junction_Homo sapiens_hsa045400.53492758
102Chemical carcinogenesis_Homo sapiens_hsa052040.52913447
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52421619
104Circadian entrainment_Homo sapiens_hsa047130.52382473
105Propanoate metabolism_Homo sapiens_hsa006400.52167259
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51476000
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51438835
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50220986
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.49954155
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49254691
111Chemokine signaling pathway_Homo sapiens_hsa040620.49110021
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48780816
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48685307
114Malaria_Homo sapiens_hsa051440.48359704
115Dilated cardiomyopathy_Homo sapiens_hsa054140.48296082
116Pyruvate metabolism_Homo sapiens_hsa006200.48138170
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.46886882
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.46808060
119Huntingtons disease_Homo sapiens_hsa050160.46801252
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46648492
121mRNA surveillance pathway_Homo sapiens_hsa030150.46246220
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45700105
123Lysosome_Homo sapiens_hsa041420.45651779
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.45635124
125Glycerolipid metabolism_Homo sapiens_hsa005610.45507609
126RNA degradation_Homo sapiens_hsa030180.45379946
127Metabolic pathways_Homo sapiens_hsa011000.44449540
128Salivary secretion_Homo sapiens_hsa049700.43847423
129Morphine addiction_Homo sapiens_hsa050320.43031915
130Retinol metabolism_Homo sapiens_hsa008300.42753248
131Mineral absorption_Homo sapiens_hsa049780.42477285
132Melanogenesis_Homo sapiens_hsa049160.42092560
133Renin secretion_Homo sapiens_hsa049240.42033561
134Arachidonic acid metabolism_Homo sapiens_hsa005900.41962730
135Caffeine metabolism_Homo sapiens_hsa002320.40926177
136Bile secretion_Homo sapiens_hsa049760.40778921
137Phagosome_Homo sapiens_hsa041450.40695159
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40663155
139Parkinsons disease_Homo sapiens_hsa050120.40108017
140GABAergic synapse_Homo sapiens_hsa047270.39760565
141Cardiac muscle contraction_Homo sapiens_hsa042600.38007813
142Ribosome_Homo sapiens_hsa030100.37636412
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36657674
144beta-Alanine metabolism_Homo sapiens_hsa004100.35641083
145Oxytocin signaling pathway_Homo sapiens_hsa049210.34616645
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34268079
147Dopaminergic synapse_Homo sapiens_hsa047280.34241445
148Thyroid hormone synthesis_Homo sapiens_hsa049180.33223303
149Primary immunodeficiency_Homo sapiens_hsa053400.33130867
150Amphetamine addiction_Homo sapiens_hsa050310.30542821
151Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29426742
152Leishmaniasis_Homo sapiens_hsa051400.29318388
153Long-term potentiation_Homo sapiens_hsa047200.28702095
154Tuberculosis_Homo sapiens_hsa051520.28628358
155Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28009975

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