KLHL36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.13613949
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13613949
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36260458
4positive regulation of gamma-delta T cell activation (GO:0046645)5.34634728
5antigen processing and presentation of endogenous antigen (GO:0019883)5.21487049
6antigen processing and presentation via MHC class Ib (GO:0002475)4.98483541
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95535190
8positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.91256926
9DNA deamination (GO:0045006)4.77216136
10regulation of B cell receptor signaling pathway (GO:0050855)4.72457142
11regulation of gamma-delta T cell differentiation (GO:0045586)4.42851110
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.12271855
13negative regulation of erythrocyte differentiation (GO:0045647)4.07012115
14regulation of gamma-delta T cell activation (GO:0046643)4.06121271
15regulation of B cell differentiation (GO:0045577)3.99816475
16mannose metabolic process (GO:0006013)3.89795616
17response to interferon-beta (GO:0035456)3.83924165
18response to interferon-alpha (GO:0035455)3.54297202
19regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.52229663
20positive thymic T cell selection (GO:0045059)3.51247530
21regulation of type I interferon-mediated signaling pathway (GO:0060338)3.43880265
22positive regulation of B cell differentiation (GO:0045579)3.41517143
23type I interferon signaling pathway (GO:0060337)3.29662162
24cellular response to type I interferon (GO:0071357)3.29662162
25positive regulation of lamellipodium organization (GO:1902745)3.28606603
26positive regulation of lamellipodium assembly (GO:0010592)3.28285508
27response to type I interferon (GO:0034340)3.27622838
28negative regulation of glycoprotein biosynthetic process (GO:0010561)3.26773488
29leukocyte aggregation (GO:0070486)3.26760481
30B cell receptor signaling pathway (GO:0050853)3.24473331
31response to interleukin-15 (GO:0070672)3.23422670
32B cell mediated immunity (GO:0019724)3.22628331
33valine metabolic process (GO:0006573)3.22481949
34cellular response to interferon-beta (GO:0035458)3.22306092
35platelet dense granule organization (GO:0060155)3.19731812
36T cell selection (GO:0045058)3.19395249
37positive regulation by symbiont of host defense response (GO:0052509)3.18091260
38modulation by symbiont of host defense response (GO:0052031)3.18091260
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18091260
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18091260
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.18091260
42modulation by symbiont of host immune response (GO:0052553)3.18091260
43galactose catabolic process (GO:0019388)3.17871036
44positive regulation of interferon-alpha production (GO:0032727)3.15726424
45maturation of SSU-rRNA (GO:0030490)3.13843966
46immunoglobulin mediated immune response (GO:0016064)3.12198426
47pentose-phosphate shunt (GO:0006098)3.09215765
48positive regulation of tolerance induction (GO:0002645)3.08360535
49regulation of response to interferon-gamma (GO:0060330)3.07521430
50ribosomal small subunit assembly (GO:0000028)3.03877903
51regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.02290578
52negative regulation of fatty acid transport (GO:2000192)3.02219145
53histone H3-K36 demethylation (GO:0070544)3.01989171
54positive T cell selection (GO:0043368)3.00140175
55mature B cell differentiation involved in immune response (GO:0002313)2.97638747
56negative regulation of innate immune response (GO:0045824)2.94138993
57regulation of interferon-alpha production (GO:0032647)2.92693946
58viral transcription (GO:0019083)2.92043760
59actin nucleation (GO:0045010)2.88408012
60T cell homeostasis (GO:0043029)2.87737000
61cytokinetic process (GO:0032506)2.85416646
62response to peptidoglycan (GO:0032494)2.85348021
63natural killer cell differentiation (GO:0001779)2.84665160
64negative regulation of interleukin-12 production (GO:0032695)2.84089901
65regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83658079
66regulation of extracellular matrix disassembly (GO:0010715)2.83281582
67negative thymic T cell selection (GO:0045060)2.82950113
68negative regulation of phagocytosis (GO:0050765)2.82670433
69response to muramyl dipeptide (GO:0032495)2.81205618
70mucosal-associated lymphoid tissue development (GO:0048537)2.80699707
71Peyers patch development (GO:0048541)2.80699707
72mature B cell differentiation (GO:0002335)2.77961568
73thymic T cell selection (GO:0045061)2.76226919
74regulation of interferon-beta biosynthetic process (GO:0045357)2.75820830
75regulation of monocyte differentiation (GO:0045655)2.74499014
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72310932
77negative regulation of cell killing (GO:0031342)2.72310932
78translational termination (GO:0006415)2.71061673
79JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70307507
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68540145
81negative T cell selection (GO:0043383)2.67681495
82negative regulation of lymphocyte mediated immunity (GO:0002707)2.66495799
83detection of other organism (GO:0098543)2.66494252
84megakaryocyte development (GO:0035855)2.65984397
85interferon-gamma-mediated signaling pathway (GO:0060333)2.65135775
86NIK/NF-kappaB signaling (GO:0038061)2.64947504
87necroptotic process (GO:0070266)2.64349200
88negative regulation of T cell mediated immunity (GO:0002710)2.64270836
89tolerance induction (GO:0002507)2.63752292
90negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.63342483
91regulation of tolerance induction (GO:0002643)2.62559811
92SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62496770
93detection of bacterium (GO:0016045)2.61212899
94response to laminar fluid shear stress (GO:0034616)2.60587869
95defense response to protozoan (GO:0042832)2.60261518
96NADPH regeneration (GO:0006740)2.60229385
97cellular response to dsRNA (GO:0071359)2.59260020
98lymph node development (GO:0048535)2.58607380
99barbed-end actin filament capping (GO:0051016)2.58397277
100activated T cell proliferation (GO:0050798)2.57716865
101cellular response to interleukin-15 (GO:0071350)2.57643638
102regulation of fatty acid beta-oxidation (GO:0031998)2.56273580
103macrophage activation involved in immune response (GO:0002281)2.55814191
104antigen receptor-mediated signaling pathway (GO:0050851)2.54716483
105histone H3-K4 trimethylation (GO:0080182)2.54702595
106cellular extravasation (GO:0045123)2.54315576
107regulation of respiratory burst (GO:0060263)2.54023515
108germinal center formation (GO:0002467)2.52881621
109negative regulation of leukocyte mediated immunity (GO:0002704)2.52081794
110protein targeting to ER (GO:0045047)2.51410452
111response to protozoan (GO:0001562)2.49076221
112cotranslational protein targeting to membrane (GO:0006613)2.48980823
113positive regulation of Rap GTPase activity (GO:0032854)2.47742154
114translational elongation (GO:0006414)2.47383371
115protein localization to endosome (GO:0036010)2.46867941
116insulin-like growth factor receptor signaling pathway (GO:0048009)2.46604461
117regulation of interleukin-12 biosynthetic process (GO:0045075)2.46533720
118positive regulation of granulocyte differentiation (GO:0030854)2.46368094
119macrophage differentiation (GO:0030225)2.45141284
120negative regulation of glycoprotein metabolic process (GO:1903019)2.44507306
121regulation of ARF protein signal transduction (GO:0032012)2.44245948
122tricarboxylic acid metabolic process (GO:0072350)2.43970392
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.43866821
124protein localization to endoplasmic reticulum (GO:0070972)2.43011143
125regulation of natural killer cell mediated immunity (GO:0002715)2.42805002
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.42805002
127regulation of erythrocyte differentiation (GO:0045646)2.40764897
128regulation of natural killer cell differentiation (GO:0032823)2.40635058
129regulation of necroptotic process (GO:0060544)2.39951876
130positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.39539686
131endosome to pigment granule transport (GO:0043485)2.37578838
132endosome to melanosome transport (GO:0035646)2.37578838
133embryonic process involved in female pregnancy (GO:0060136)2.35955519
134regulation of histone H3-K27 methylation (GO:0061085)2.34255935
135response to host (GO:0075136)2.32396275
136response to host defenses (GO:0052200)2.32396275
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.32396275
138activation of JUN kinase activity (GO:0007257)2.31377316
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.31233647
140hepatocyte apoptotic process (GO:0097284)2.31109223
141macroautophagy (GO:0016236)2.30557377
142interferon-gamma secretion (GO:0072643)2.29399784
143regulation of granulocyte differentiation (GO:0030852)2.28284938
144negative regulation of granulocyte differentiation (GO:0030853)2.27495066
145regulation of T cell tolerance induction (GO:0002664)2.23621055
146detection of external biotic stimulus (GO:0098581)2.20112565
147positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20065890
148phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.18240626
149regulation of defense response to virus by virus (GO:0050690)2.17997689
150striated muscle atrophy (GO:0014891)2.16549938
151positive regulation of CREB transcription factor activity (GO:0032793)2.15469733
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.15319144
153positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.14357906
154B cell homeostasis (GO:0001782)2.13953988
155stress fiber assembly (GO:0043149)2.12661115
156regulation of leukocyte degranulation (GO:0043300)2.10956993
157regulation of extracellular matrix organization (GO:1903053)2.10435274
158cytoplasmic mRNA processing body assembly (GO:0033962)2.09537347
159positive regulation of histone deacetylation (GO:0031065)2.09494300
160positive regulation of extracellular matrix organization (GO:1903055)2.07472791
161T cell migration (GO:0072678)2.06496320
162growth hormone receptor signaling pathway (GO:0060396)2.04545172
163positive regulation of Cdc42 GTPase activity (GO:0043089)2.03772243
164cell-substrate adherens junction assembly (GO:0007045)2.03612912
165focal adhesion assembly (GO:0048041)2.03612912
166ear development (GO:0043583)2.02918980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.75556333
2MYC_22102868_ChIP-Seq_BL_Human3.19214036
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.00343127
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89343313
5VDR_21846776_ChIP-Seq_THP-1_Human2.80855879
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79694317
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.78967428
8SCL_19346495_ChIP-Seq_HPC-7_Human2.77838615
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.64992308
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56694400
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52357816
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46262167
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45925033
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36766811
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33763266
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.31270465
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.23929976
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23006841
19MAF_26560356_Chip-Seq_TH1_Human2.20734326
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16540261
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16454246
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13592670
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09928647
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04770912
25* UTX_26944678_Chip-Seq_JUKART_Human1.97487275
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95276389
27VDR_24763502_ChIP-Seq_THP-1_Human1.92928506
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.92207582
29* SPI1_23547873_ChIP-Seq_NB4_Human1.91633923
30TCF7_22412390_ChIP-Seq_EML_Mouse1.90723027
31* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.87877553
32* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85308490
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82307704
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.82302211
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.82206084
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81979166
37MYB_26560356_Chip-Seq_TH2_Human1.81353667
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80539309
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.79459512
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.78093577
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76313146
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.75567079
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.75314343
44MYB_26560356_Chip-Seq_TH1_Human1.71711024
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69994393
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67218198
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67130354
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.67048002
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65407502
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59756275
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56033817
52* RACK7_27058665_Chip-Seq_MCF-7_Human1.55923176
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55224862
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.54786166
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54648438
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54130782
57FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52953863
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52865742
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.52305547
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.51792606
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.50763559
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.50099815
63RUNX_20019798_ChIP-Seq_JUKART_Human1.48930293
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47488414
65* LXR_22292898_ChIP-Seq_THP-1_Human1.46671134
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.44861388
67AHR_22903824_ChIP-Seq_MCF-7_Human1.44390865
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43952783
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42087157
70SPI1_23127762_ChIP-Seq_K562_Human1.42014367
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41995868
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41846371
73MAF_26560356_Chip-Seq_TH2_Human1.40572369
74KDM2B_26808549_Chip-Seq_K562_Human1.40280288
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.40138412
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39905221
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38271258
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37807771
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36073892
80CIITA_25753668_ChIP-Seq_RAJI_Human1.34738211
81E2F7_22180533_ChIP-Seq_HELA_Human1.32886265
82KDM2B_26808549_Chip-Seq_DND41_Human1.32440459
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32336915
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.32257548
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31992352
86VDR_24787735_ChIP-Seq_THP-1_Human1.31967948
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31222507
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29931380
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29606379
90GATA1_19941826_ChIP-Seq_K562_Human1.27729213
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27610257
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27524266
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27049592
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26961467
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26894264
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25771128
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25714221
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21633739
99GATA3_27048872_Chip-Seq_THYMUS_Human1.17666229
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17166056
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16427145
102XRN2_22483619_ChIP-Seq_HELA_Human1.16368726
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16034624
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15887430
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15403101
106BCL6_27268052_Chip-Seq_Bcells_Human1.15045827
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.14721017
108DROSHA_22980978_ChIP-Seq_HELA_Human1.14071277
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11921266
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.11737611
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11595235
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11173246
113* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11043668
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10650180
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10356770
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09828885
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09617560
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08385177
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08348068
120* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07811644
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.07649745
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07256530
123FOXP3_21729870_ChIP-Seq_TREG_Human1.05569216
124GABP_19822575_ChIP-Seq_HepG2_Human1.05243406
125CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04117290
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03999717
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03769194
128FOXA2_19822575_ChIP-Seq_HepG2_Human1.02974654
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02896291
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02318972
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01113631
132TBX20_22080862_ChIP-Seq_HEART_Mouse1.00550841
133TBX20_22328084_ChIP-Seq_HEART_Mouse1.00550841
134GATA2_19941826_ChIP-Seq_K562_Human1.00484538
135* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00443941
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99876587
137SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99686862
138SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99686862
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99584964
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99323920
141EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99312971
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.98644140
143P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98387922
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98327502
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97501348
146GATA1_22025678_ChIP-Seq_K562_Human0.97275090
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97055900
148VDR_23849224_ChIP-Seq_CD4+_Human0.96775043
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95259165
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95107166
151TFEB_21752829_ChIP-Seq_HELA_Human0.93829891
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93562665
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93436000
154CLOCK_20551151_ChIP-Seq_293T_Human0.93226899
155BCOR_27268052_Chip-Seq_Bcells_Human0.93023738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.59596162
2MP0000685_abnormal_immune_system3.45528571
3MP0003705_abnormal_hypodermis_morpholog3.36417540
4MP0009785_altered_susceptibility_to3.23977407
5MP0003763_abnormal_thymus_physiology3.15579811
6MP0005671_abnormal_response_to2.67172529
7MP0005025_abnormal_response_to2.49475912
8MP0002254_reproductive_system_inflammat2.43222768
9MP0003436_decreased_susceptibility_to2.41496877
10MP0003724_increased_susceptibility_to2.41433753
11MP0001800_abnormal_humoral_immune2.35712579
12MP0003300_gastrointestinal_ulcer2.32757007
13MP0002723_abnormal_immune_serum2.31124736
14MP0005409_darkened_coat_color2.27585709
15MP0002452_abnormal_antigen_presenting2.25884474
16MP0002420_abnormal_adaptive_immunity2.24854175
17MP0005000_abnormal_immune_tolerance2.23508537
18MP0001819_abnormal_immune_cell2.22671273
19MP0002398_abnormal_bone_marrow2.19393385
20MP0002396_abnormal_hematopoietic_system2.17867874
21MP0002419_abnormal_innate_immunity2.17560908
22MP0001873_stomach_inflammation2.14817627
23MP0001790_abnormal_immune_system2.06927041
24MP0005387_immune_system_phenotype2.06927041
25MP0005464_abnormal_platelet_physiology2.06824701
26MP0003091_abnormal_cell_migration2.04233711
27MP0001958_emphysema2.03707049
28MP0004381_abnormal_hair_follicle2.01427856
29MP0006054_spinal_hemorrhage1.99829968
30MP0000465_gastrointestinal_hemorrhage1.99323434
31MP0005076_abnormal_cell_differentiation1.97893216
32MP0000716_abnormal_immune_system1.96444976
33MP0000689_abnormal_spleen_morphology1.90327069
34MP0002722_abnormal_immune_system1.88612656
35MP0002166_altered_tumor_susceptibility1.88079973
36MP0010234_abnormal_vibrissa_follicle1.85694137
37MP0004947_skin_inflammation1.84673590
38MP0002405_respiratory_system_inflammati1.82505720
39MP0005058_abnormal_lysosome_morphology1.82348277
40MP0001845_abnormal_inflammatory_respons1.79747545
41MP0002009_preneoplasia1.78355080
42MP0003303_peritoneal_inflammation1.75768712
43MP0002429_abnormal_blood_cell1.74298351
44MP0001853_heart_inflammation1.72921035
45MP0010155_abnormal_intestine_physiology1.71887721
46MP0003566_abnormal_cell_adhesion1.71008554
47MP0003828_pulmonary_edema1.70346906
48MP0009840_abnormal_foam_cell1.70188728
49MP0000569_abnormal_digit_pigmentation1.68813122
50MP0002139_abnormal_hepatobiliary_system1.68562866
51MP0005397_hematopoietic_system_phenotyp1.65932992
52MP0001545_abnormal_hematopoietic_system1.65932992
53MP0009333_abnormal_splenocyte_physiolog1.63650016
54MP0008469_abnormal_protein_level1.62637560
55MP0000703_abnormal_thymus_morphology1.62372444
56MP0004808_abnormal_hematopoietic_stem1.58799815
57MP0003191_abnormal_cellular_cholesterol1.57727741
58MP0004130_abnormal_muscle_cell1.56575124
59MP0010368_abnormal_lymphatic_system1.54716736
60MP0003172_abnormal_lysosome_physiology1.53267774
61MP0002148_abnormal_hypersensitivity_rea1.51886458
62MP0003866_abnormal_defecation1.50216436
63MP0004185_abnormal_adipocyte_glucose1.48787239
64MP0006082_CNS_inflammation1.45985866
65MP0005365_abnormal_bile_salt1.45554645
66MP0003011_delayed_dark_adaptation1.42200126
67MP0001348_abnormal_lacrimal_gland1.41235031
68MP0000490_abnormal_crypts_of1.39571173
69MP0003279_aneurysm1.39485596
70MP0003453_abnormal_keratinocyte_physiol1.37078746
71MP0005360_urolithiasis1.35281435
72MP0000858_altered_metastatic_potential1.32561573
73MP0004883_abnormal_blood_vessel1.32398667
74MP0002006_tumorigenesis1.30347327
75MP0004264_abnormal_extraembryonic_tissu1.29937993
76MP0000609_abnormal_liver_physiology1.29695221
77MP0005451_abnormal_body_composition1.28575404
78MP0009278_abnormal_bone_marrow1.27730846
79MP0008438_abnormal_cutaneous_collagen1.25781577
80MP0000767_abnormal_smooth_muscle1.24939872
81MP0001849_ear_inflammation1.23815236
82MP0001533_abnormal_skeleton_physiology1.23784470
83MP0005174_abnormal_tail_pigmentation1.23463498
84MP0002933_joint_inflammation1.20090481
85MP0000015_abnormal_ear_pigmentation1.19579204
86MP0002796_impaired_skin_barrier1.15613413
87MP0005075_abnormal_melanosome_morpholog1.15553099
88MP0003045_fibrosis1.12545795
89MP0004510_myositis1.11260739
90MP0005319_abnormal_enzyme/_coenzyme1.10968751
91MP0009643_abnormal_urine_homeostasis1.08301679
92MP0002138_abnormal_hepatobiliary_system1.07128033
93MP0001851_eye_inflammation1.07115507
94MP0002909_abnormal_adrenal_gland1.05596051
95MP0010678_abnormal_skin_adnexa1.01408159
96MP0008007_abnormal_cellular_replicative1.01334534
97MP0009763_increased_sensitivity_to1.00907782
98MP0003943_abnormal_hepatobiliary_system1.00432724
99MP0002877_abnormal_melanocyte_morpholog0.99596524
100MP0000598_abnormal_liver_morphology0.98156899
101MP0008260_abnormal_autophagy0.97221128
102MP0005310_abnormal_salivary_gland0.97190181
103MP0002928_abnormal_bile_duct0.97128093
104MP0005220_abnormal_exocrine_pancreas0.96843196
105MP0002019_abnormal_tumor_incidence0.94915650
106MP0000371_diluted_coat_color0.93221962
107MP0005164_abnormal_response_to0.92961979
108MP0010329_abnormal_lipoprotein_level0.92579249
109MP0003183_abnormal_peptide_metabolism0.92334359
110MP0003806_abnormal_nucleotide_metabolis0.92080343
111MP0005666_abnormal_adipose_tissue0.91889915
112MP0009764_decreased_sensitivity_to0.90406637
113MP0005375_adipose_tissue_phenotype0.90392918
114MP0005584_abnormal_enzyme/coenzyme_acti0.90041587
115MP0005275_abnormal_skin_tensile0.89982326
116MP0000383_abnormal_hair_follicle0.88687811
117MP0001764_abnormal_homeostasis0.86907987
118MP0000427_abnormal_hair_cycle0.86570412
119MP0005167_abnormal_blood-brain_barrier0.84234140
120MP0009384_cardiac_valve_regurgitation0.83393309
121MP0002998_abnormal_bone_remodeling0.82422444
122MP0005023_abnormal_wound_healing0.82243391
123MP0005332_abnormal_amino_acid0.81158344
124MP0002089_abnormal_postnatal_growth/wei0.80917415
125MP0001661_extended_life_span0.80323237
126MP0008875_abnormal_xenobiotic_pharmacok0.80095844
127MP0000470_abnormal_stomach_morphology0.79111582
128MP0008961_abnormal_basal_metabolism0.78900174
129MP0009115_abnormal_fat_cell0.78405083
130MP0001879_abnormal_lymphatic_vessel0.77368445
131MP0000377_abnormal_hair_follicle0.76971415
132MP0005390_skeleton_phenotype0.76688988
133MP0005085_abnormal_gallbladder_physiolo0.76523026
134MP0009780_abnormal_chondrocyte_physiolo0.76443637
135MP0003075_altered_response_to0.76140209
136MP0001216_abnormal_epidermal_layer0.75728829
137MP0000477_abnormal_intestine_morphology0.75283154
138MP0002136_abnormal_kidney_physiology0.74413242
139MP0000343_altered_response_to0.73300511
140MP0009642_abnormal_blood_homeostasis0.70631108
141MP0002693_abnormal_pancreas_physiology0.70170663
142MP0000313_abnormal_cell_death0.68246230
143MP0000249_abnormal_blood_vessel0.67976364
144MP0005084_abnormal_gallbladder_morpholo0.66997216

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.74392720
2IgM deficiency (HP:0002850)4.62107748
3Thrombocytosis (HP:0001894)3.89924144
4Reticulocytopenia (HP:0001896)3.74634360
5Myositis (HP:0100614)3.74458726
6Recurrent abscess formation (HP:0002722)3.65201826
7Spontaneous hematomas (HP:0007420)3.46430091
8Mediastinal lymphadenopathy (HP:0100721)3.36946136
9Abnormality of the nasal mucosa (HP:0000433)3.36775393
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.30132990
11Chronic otitis media (HP:0000389)3.23704536
12Fatigue (HP:0012378)3.14488878
13Recurrent bronchitis (HP:0002837)3.05169660
14Arterial tortuosity (HP:0005116)3.02666203
15Eczematoid dermatitis (HP:0000976)2.97674468
16Recurrent bacterial skin infections (HP:0005406)2.95762862
17Thin bony cortex (HP:0002753)2.93333412
18Abnormality of cells of the lymphoid lineage (HP:0012140)2.88277475
19Lymphopenia (HP:0001888)2.86230243
20Nasal polyposis (HP:0100582)2.86124130
21Vascular tortuosity (HP:0004948)2.85737364
22Abnormality of T cell physiology (HP:0011840)2.84892127
23Interstitial pulmonary disease (HP:0006530)2.84762067
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.84309411
25Dysostosis multiplex (HP:0000943)2.79912183
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79480787
27Reduced antithrombin III activity (HP:0001976)2.78610377
28Abnormality of T cells (HP:0002843)2.77835045
29Gastrointestinal inflammation (HP:0004386)2.73611001
30Recurrent gram-negative bacterial infections (HP:0005420)2.73570439
31Recurrent skin infections (HP:0001581)2.71536909
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70062971
33Recurrent fungal infections (HP:0002841)2.66317322
34Inflammation of the large intestine (HP:0002037)2.63456517
35Aortic aneurysm (HP:0004942)2.58093302
36Petechiae (HP:0000967)2.57223777
37Recurrent viral infections (HP:0004429)2.57144828
38Colitis (HP:0002583)2.56894556
39Pigmentary retinal degeneration (HP:0001146)2.56774815
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56346706
41Panhypogammaglobulinemia (HP:0003139)2.56318448
42Broad face (HP:0000283)2.50320932
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41901774
44Bony spicule pigmentary retinopathy (HP:0007737)2.40749254
45Orchitis (HP:0100796)2.39962345
46Abnormality of pyrimidine metabolism (HP:0004353)2.39354476
47Autoimmune hemolytic anemia (HP:0001890)2.35948450
48Protrusio acetabuli (HP:0003179)2.35935660
49Chronic mucocutaneous candidiasis (HP:0002728)2.35483033
50Recurrent cutaneous fungal infections (HP:0011370)2.35483033
51Nonimmune hydrops fetalis (HP:0001790)2.33362411
52Abnormal rod and cone electroretinograms (HP:0008323)2.32637809
53B lymphocytopenia (HP:0010976)2.32546608
54Abnormality of B cell number (HP:0010975)2.32546608
55Agammaglobulinemia (HP:0004432)2.30439405
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29924083
57Abnormal protein N-linked glycosylation (HP:0012347)2.29924083
58Abnormal protein glycosylation (HP:0012346)2.29924083
59Abnormal glycosylation (HP:0012345)2.29924083
60Aplastic anemia (HP:0001915)2.29359299
61Epistaxis (HP:0000421)2.29333792
62Acute lymphatic leukemia (HP:0006721)2.29323576
63Meningitis (HP:0001287)2.28560278
64Prolonged bleeding time (HP:0003010)2.28542061
65Increased IgE level (HP:0003212)2.27760617
66Mucopolysacchariduria (HP:0008155)2.27507561
67Urinary glycosaminoglycan excretion (HP:0003541)2.27507561
68Abnormal platelet function (HP:0011869)2.19823657
69Impaired platelet aggregation (HP:0003540)2.19823657
70Abnormality of macrophages (HP:0004311)2.19425934
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18645048
72Spondylolisthesis (HP:0003302)2.18416419
73Thoracic kyphosis (HP:0002942)2.18252557
74Optic neuritis (HP:0100653)2.18242584
75Retrobulbar optic neuritis (HP:0100654)2.18242584
76Gastrointestinal infarctions (HP:0005244)2.18056436
77T lymphocytopenia (HP:0005403)2.17564089
78Cardiomegaly (HP:0001640)2.17496475
79Increased cerebral lipofuscin (HP:0011813)2.16796441
80Gingivitis (HP:0000230)2.15866626
81Type I transferrin isoform profile (HP:0003642)2.15596508
82Papilloma (HP:0012740)2.14875331
83Verrucae (HP:0200043)2.14875331
84Increased neuronal autofluorescent lipopigment (HP:0002074)2.14336900
85Abnormality of T cell number (HP:0011839)2.14076746
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13672103
87Abnormality of polysaccharide metabolism (HP:0011012)2.13672103
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13672103
89Polycythemia (HP:0001901)2.13244776
90IgG deficiency (HP:0004315)2.13116052
91Cerebral aneurysm (HP:0004944)2.12834482
92Progressive neurologic deterioration (HP:0002344)2.12240948
93Mitral regurgitation (HP:0001653)2.11638167
94Microretrognathia (HP:0000308)2.11214843
95Delayed CNS myelination (HP:0002188)2.10896581
96Congenital stationary night blindness (HP:0007642)2.10254216
97Loss of speech (HP:0002371)2.09666816
98Hematochezia (HP:0002573)2.09133581
99Dilatation of the ascending aorta (HP:0005111)2.08123211
100Subacute progressive viral hepatitis (HP:0006572)2.06768287
101Asymmetry of the thorax (HP:0001555)2.04163951
102Microcytic anemia (HP:0001935)2.03894113
103Albinism (HP:0001022)2.03244959
104Obstructive sleep apnea (HP:0002870)2.03222975
105Urticaria (HP:0001025)2.02592057
106Aneurysm (HP:0002617)2.02016117
107Abnormality of the fingertips (HP:0001211)2.01879388
108Long toe (HP:0010511)2.01747078
109Pustule (HP:0200039)2.01105625
110Polygenic inheritance (HP:0010982)1.99738108
111Abnormality of DNA repair (HP:0003254)1.98572490
112Hyperacusis (HP:0010780)1.97435446
113Cellulitis (HP:0100658)1.97227945
114Neoplasm of head and neck (HP:0012288)1.97080317
115Esophageal neoplasm (HP:0100751)1.97080317
116Spinal cord lesions (HP:0100561)1.96867207
117Syringomyelia (HP:0003396)1.96867207
118Emphysema (HP:0002097)1.95789435
119Broad metatarsal (HP:0001783)1.95633439
120Vacuolated lymphocytes (HP:0001922)1.95398114
121Aortic dissection (HP:0002647)1.95326444
122Systemic lupus erythematosus (HP:0002725)1.94111192
123Persistence of primary teeth (HP:0006335)1.92764958
124J-shaped sella turcica (HP:0002680)1.92693880
125Abnormality of fatty-acid metabolism (HP:0004359)1.92429259
126Segmental peripheral demyelination/remyelination (HP:0003481)1.91493075
127Germ cell neoplasia (HP:0100728)1.90860872
128Asymmetric septal hypertrophy (HP:0001670)1.88671421
129Periodontitis (HP:0000704)1.88414811
130Flat acetabular roof (HP:0003180)1.88116864
131Posterior subcapsular cataract (HP:0007787)1.87380619
132Purpura (HP:0000979)1.87342969
133Vasculitis (HP:0002633)1.86861136
134Gastrointestinal stroma tumor (HP:0100723)1.86349909
135Peritonitis (HP:0002586)1.85229514
136Hypoplasia of the thymus (HP:0000778)1.83934062
137Hemoptysis (HP:0002105)1.83541644
138Chest pain (HP:0100749)1.81162350
139Abnormality of the thoracic spine (HP:0100711)1.80430812
140Abnormality of the radial head (HP:0003995)1.78041992
141Dislocated radial head (HP:0003083)1.76667736
142Pulmonary infiltrates (HP:0002113)1.75031078
143Deformed sella turcica (HP:0002681)1.73032809
144Cervical subluxation (HP:0003308)1.72686917
145Mitral valve prolapse (HP:0001634)1.71490889
146Macroorchidism (HP:0000053)1.70898736
147Absent frontal sinuses (HP:0002688)1.70101584
148Coarse hair (HP:0002208)1.67190392
149Striae distensae (HP:0001065)1.67095669
150Global brain atrophy (HP:0002283)1.66005404
151Viral hepatitis (HP:0006562)1.65397681
152Aortic regurgitation (HP:0001659)1.63866531
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62279512
154Distal lower limb amyotrophy (HP:0008944)1.61563275
155Micronodular cirrhosis (HP:0001413)1.61317689
156Vertebral arch anomaly (HP:0008438)1.60758663
157Abnormality of oral frenula (HP:0000190)1.58606762
158Glucose intolerance (HP:0000833)1.58128786
159Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.58118740
160Joint laxity (HP:0001388)1.57811999
161Abnormal glucose tolerance (HP:0001952)1.57641911
162Abnormality of liposaccharide metabolism (HP:0010968)1.57513517
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.57513517
164Abnormality of glycolipid metabolism (HP:0010969)1.57513517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.74696866
2FLT33.96680900
3MAP4K13.43149214
4ERN13.22502259
5PRPF4B2.94037324
6BLK2.91405344
7KIT2.86684142
8TBK12.59100965
9BRSK22.51845655
10ZAP702.42915947
11TGFBR22.39029660
12EEF2K2.28940461
13JAK32.28234996
14TYK22.24207341
15TGFBR12.14176465
16PKN22.12928440
17SCYL22.09160220
18TESK21.99314584
19IKBKE1.84056884
20TAOK31.82151077
21TRIB31.80511316
22EPHB11.77235315
23TEC1.71477070
24CSF1R1.65417241
25ICK1.62771904
26BTK1.57193691
27NME21.55593428
28MAP3K101.54474065
29LRRK21.53280680
30SMG11.45829883
31CDC42BPA1.34459488
32KSR21.33466201
33FGFR41.31028920
34TTN1.30695696
35IRAK41.29811001
36MARK31.28597002
37PRKD21.27714405
38MAP3K131.25705459
39STK101.23985110
40FES1.21957521
41JAK11.21862219
42MAP3K21.21148325
43EPHA31.17227579
44SIK21.16881005
45ACVR1B1.15899213
46TXK1.15264703
47TRPM71.14311292
48MAPKAPK31.14108428
49MAP3K91.11892492
50CAMKK11.10363874
51SYK1.09570188
52RET1.09528282
53LCK1.08080287
54BCKDK1.06802026
55MAP3K71.05972923
56MAP3K31.05236358
57PDGFRB1.01987337
58CLK11.01364192
59PASK0.98802093
60PIM20.98382706
61MAP3K140.97222869
62PDGFRA0.97095723
63MELK0.96532306
64STK380.96380568
65RPS6KA20.93501032
66CDK120.91405503
67PDK10.90703735
68MAP3K10.90465750
69MAP2K30.89998238
70PDPK10.89538746
71ITK0.88269716
72TNIK0.81942341
73TIE10.81146133
74MAPK110.80764323
75PAK40.79139470
76SGK30.79029305
77CSK0.77823789
78GRK60.76868168
79DYRK1B0.76715977
80PTK60.75618890
81IRAK10.75038220
82NLK0.75012413
83HCK0.74570226
84LYN0.73691323
85RPS6KA40.73681619
86IKBKB0.70838843
87RPS6KC10.70357189
88RPS6KL10.70357189
89BRSK10.69429271
90JAK20.69123690
91BRD40.69027131
92NEK20.68522824
93YES10.67633123
94KSR10.66983344
95PRKG20.66310129
96TYRO30.66143156
97CAMKK20.65756464
98RPS6KA60.65468694
99MTOR0.64756811
100EPHA20.64409500
101MAPK150.62659654
102TAOK10.61913579
103MATK0.61654959
104SGK20.61385398
105CDK80.60691241
106MAPK70.60236150
107CAMK1D0.58411776
108MAP3K60.57884362
109FGFR30.57787781
110MARK20.57029856
111MUSK0.56517012
112WNK10.53338650
113GRK10.53333272
114MAPK120.53313785
115MAPK40.50261760
116MAP3K110.50077368
117CDK60.49861370
118RPS6KB20.48462154
119NEK60.48426008
120SIK10.47094915
121PIK3CA0.46236534
122VRK10.42525987
123MYLK0.41038655
124CDK90.40935030
125TESK10.37645489
126MAP2K60.35958741
127STK160.33866318
128ATR0.33806979
129CHUK0.33462709
130PIM10.33433717
131TNK20.32757934
132DAPK10.32380724
133RIPK10.30559892
134CDK40.29345228
135MAPKAPK20.28494477
136RIPK40.26116752
137IRAK30.25431816
138PRKCH0.24801014
139NEK90.24687448
140HIPK20.23764129
141RAF10.22547300
142MAP3K120.22466513
143SIK30.21149824
144MAP2K20.21090817
145PRKCD0.20598779

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.39341994
2Antigen processing and presentation_Homo sapiens_hsa046122.54301629
3Caffeine metabolism_Homo sapiens_hsa002322.30045590
4B cell receptor signaling pathway_Homo sapiens_hsa046622.09221776
5Ribosome_Homo sapiens_hsa030102.07377198
6Leishmaniasis_Homo sapiens_hsa051402.06688618
7Staphylococcus aureus infection_Homo sapiens_hsa051502.04816058
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04553966
9Phototransduction_Homo sapiens_hsa047442.02911363
10Measles_Homo sapiens_hsa051621.93197516
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90706940
12Pentose phosphate pathway_Homo sapiens_hsa000301.88764308
13Selenocompound metabolism_Homo sapiens_hsa004501.86925029
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69711399
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69489922
16Other glycan degradation_Homo sapiens_hsa005111.69182697
17Hematopoietic cell lineage_Homo sapiens_hsa046401.60807280
18DNA replication_Homo sapiens_hsa030301.60746388
19N-Glycan biosynthesis_Homo sapiens_hsa005101.58102237
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.57895148
21Non-small cell lung cancer_Homo sapiens_hsa052231.56536442
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55836703
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50993653
24Renal cell carcinoma_Homo sapiens_hsa052111.49621275
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.48666659
26Shigellosis_Homo sapiens_hsa051311.48508507
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.47962659
28Folate biosynthesis_Homo sapiens_hsa007901.47947706
29Osteoclast differentiation_Homo sapiens_hsa043801.47054955
30Base excision repair_Homo sapiens_hsa034101.46473845
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46318441
32VEGF signaling pathway_Homo sapiens_hsa043701.43148910
33Sulfur relay system_Homo sapiens_hsa041221.41664941
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.39336689
35Endometrial cancer_Homo sapiens_hsa052131.38364838
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.37299883
37Herpes simplex infection_Homo sapiens_hsa051681.35348177
38T cell receptor signaling pathway_Homo sapiens_hsa046601.34465750
39Prolactin signaling pathway_Homo sapiens_hsa049171.33108719
40Acute myeloid leukemia_Homo sapiens_hsa052211.33105545
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.28956792
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28409446
43Lysosome_Homo sapiens_hsa041421.26314934
44mTOR signaling pathway_Homo sapiens_hsa041501.24771833
45Legionellosis_Homo sapiens_hsa051341.24455722
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20995758
47Inositol phosphate metabolism_Homo sapiens_hsa005621.20079989
48ErbB signaling pathway_Homo sapiens_hsa040121.19112856
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17838648
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16875509
51Dorso-ventral axis formation_Homo sapiens_hsa043201.14024074
52Insulin resistance_Homo sapiens_hsa049311.11726963
53Galactose metabolism_Homo sapiens_hsa000521.11528169
54Phospholipase D signaling pathway_Homo sapiens_hsa040721.10827318
55Choline metabolism in cancer_Homo sapiens_hsa052311.10012648
56FoxO signaling pathway_Homo sapiens_hsa040681.06060696
57GnRH signaling pathway_Homo sapiens_hsa049121.05082286
58Peroxisome_Homo sapiens_hsa041461.04758363
59Complement and coagulation cascades_Homo sapiens_hsa046101.02991806
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01492172
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01253835
62Hepatitis B_Homo sapiens_hsa051610.99564855
63Focal adhesion_Homo sapiens_hsa045100.99042796
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98781482
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97835252
66Fatty acid degradation_Homo sapiens_hsa000710.96809707
67Prostate cancer_Homo sapiens_hsa052150.95668746
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.95171159
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.94621591
70Tuberculosis_Homo sapiens_hsa051520.94596800
71Colorectal cancer_Homo sapiens_hsa052100.93955947
72Apoptosis_Homo sapiens_hsa042100.93583757
73Estrogen signaling pathway_Homo sapiens_hsa049150.93364160
74RNA degradation_Homo sapiens_hsa030180.93142831
75Glioma_Homo sapiens_hsa052140.93035573
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92168326
77Influenza A_Homo sapiens_hsa051640.92136890
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92125734
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91843545
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91586728
81Insulin signaling pathway_Homo sapiens_hsa049100.90815352
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88149893
83Pertussis_Homo sapiens_hsa051330.87816062
84Proteoglycans in cancer_Homo sapiens_hsa052050.87751092
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.87174973
86Pyrimidine metabolism_Homo sapiens_hsa002400.87047116
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85993865
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84906501
89Tryptophan metabolism_Homo sapiens_hsa003800.83921249
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83727339
91MAPK signaling pathway_Homo sapiens_hsa040100.83283950
92Notch signaling pathway_Homo sapiens_hsa043300.83169445
93Thyroid cancer_Homo sapiens_hsa052160.82826848
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82533961
95Protein export_Homo sapiens_hsa030600.82006293
96ABC transporters_Homo sapiens_hsa020100.81837823
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81447521
98Type II diabetes mellitus_Homo sapiens_hsa049300.80423545
99Small cell lung cancer_Homo sapiens_hsa052220.79784528
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79423688
101Autoimmune thyroid disease_Homo sapiens_hsa053200.78993162
102Toxoplasmosis_Homo sapiens_hsa051450.78367583
103Allograft rejection_Homo sapiens_hsa053300.78038593
104Graft-versus-host disease_Homo sapiens_hsa053320.77645991
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.76798929
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.75771619
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75151791
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75093730
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74817752
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74105469
111Biosynthesis of amino acids_Homo sapiens_hsa012300.74051404
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73065332
113Rap1 signaling pathway_Homo sapiens_hsa040150.72757627
114Adherens junction_Homo sapiens_hsa045200.71007251
115Chronic myeloid leukemia_Homo sapiens_hsa052200.70923113
116Amoebiasis_Homo sapiens_hsa051460.69595283
117Endocytosis_Homo sapiens_hsa041440.68550261
118Carbon metabolism_Homo sapiens_hsa012000.68349602
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67839230
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67059113
121Ras signaling pathway_Homo sapiens_hsa040140.66392422
122Malaria_Homo sapiens_hsa051440.66306367
123Long-term potentiation_Homo sapiens_hsa047200.66132053
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65964288
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65662588
126Bladder cancer_Homo sapiens_hsa052190.64908023
127Pyruvate metabolism_Homo sapiens_hsa006200.64869230
128HTLV-I infection_Homo sapiens_hsa051660.64823705
129MicroRNAs in cancer_Homo sapiens_hsa052060.64341151
130AMPK signaling pathway_Homo sapiens_hsa041520.64301795
131HIF-1 signaling pathway_Homo sapiens_hsa040660.63838607
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61174664
133TNF signaling pathway_Homo sapiens_hsa046680.60718315
134beta-Alanine metabolism_Homo sapiens_hsa004100.60188236
135Spliceosome_Homo sapiens_hsa030400.59279115
136Platelet activation_Homo sapiens_hsa046110.58601509
137Cholinergic synapse_Homo sapiens_hsa047250.58077011
138Epstein-Barr virus infection_Homo sapiens_hsa051690.57821926
139Chemokine signaling pathway_Homo sapiens_hsa040620.57809516
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57686854
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56743156
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54600168
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54585605
144Pathways in cancer_Homo sapiens_hsa052000.54359349
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.54022802
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51469799
147Pancreatic cancer_Homo sapiens_hsa052120.47438636
148Mismatch repair_Homo sapiens_hsa034300.47264653
149Viral carcinogenesis_Homo sapiens_hsa052030.46700428
150Lysine degradation_Homo sapiens_hsa003100.46175982
151Viral myocarditis_Homo sapiens_hsa054160.45092277
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44352692
1532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43115915
154Hepatitis C_Homo sapiens_hsa051600.43029653
155Starch and sucrose metabolism_Homo sapiens_hsa005000.42604552

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