KLHL38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)9.15429151
2muscle filament sliding (GO:0030049)9.15429151
3sarcomere organization (GO:0045214)8.76482834
4regulation of skeletal muscle contraction (GO:0014819)8.07240965
5sarcoplasmic reticulum calcium ion transport (GO:0070296)7.76808742
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.64537282
7myofibril assembly (GO:0030239)7.55014610
8actin-mediated cell contraction (GO:0070252)7.51898947
9cardiac myofibril assembly (GO:0055003)7.20808909
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.70804196
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.64462692
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.55812689
13skeletal muscle adaptation (GO:0043501)6.47240018
14plasma membrane repair (GO:0001778)6.44984103
15skeletal muscle fiber development (GO:0048741)6.30949558
16skeletal muscle contraction (GO:0003009)6.27607096
17carnitine shuttle (GO:0006853)6.06294570
18cardiac muscle contraction (GO:0060048)6.01694538
19regulation of cell communication by electrical coupling (GO:0010649)5.95130599
20striated muscle contraction (GO:0006941)5.94423676
21regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.93623508
22regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.86897267
23negative regulation of potassium ion transmembrane transport (GO:1901380)5.85769707
24regulation of relaxation of muscle (GO:1901077)5.80730519
25tricarboxylic acid cycle (GO:0006099)5.72602116
26actomyosin structure organization (GO:0031032)5.67251648
27myotube cell development (GO:0014904)5.66102343
28actin filament-based movement (GO:0030048)5.63846922
29regulation of actin filament-based movement (GO:1903115)5.57687948
30regulation of acyl-CoA biosynthetic process (GO:0050812)5.47395593
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.40274998
32cardiac muscle cell development (GO:0055013)5.34099082
33fatty acid transmembrane transport (GO:1902001)5.19270207
34striated muscle atrophy (GO:0014891)5.03485297
35cardiac cell development (GO:0055006)4.99529433
36creatine metabolic process (GO:0006600)4.97918690
37regulation of coenzyme metabolic process (GO:0051196)4.97859946
38regulation of cofactor metabolic process (GO:0051193)4.97859946
39regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.89021941
40response to inactivity (GO:0014854)4.85056683
41heart contraction (GO:0060047)4.84052782
42heart process (GO:0003015)4.84052782
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.76443018
44cardiac muscle tissue morphogenesis (GO:0055008)4.66658000
45cardiac muscle hypertrophy (GO:0003300)4.64638685
46adult heart development (GO:0007512)4.62729032
47striated muscle adaptation (GO:0014888)4.54444260
48regulation of striated muscle contraction (GO:0006942)4.54415873
49skeletal muscle tissue development (GO:0007519)4.54260286
50striated muscle hypertrophy (GO:0014897)4.52924683
51carnitine transmembrane transport (GO:1902603)4.45346951
52muscle contraction (GO:0006936)4.44722459
53glycogen catabolic process (GO:0005980)4.43190229
54regulation of sarcomere organization (GO:0060297)4.41431922
55ventricular cardiac muscle cell action potential (GO:0086005)4.37969935
56muscle tissue morphogenesis (GO:0060415)4.36045049
57muscle atrophy (GO:0014889)4.32265409
58glucan catabolic process (GO:0009251)4.13345348
59muscle cell cellular homeostasis (GO:0046716)4.12725292
60fructose metabolic process (GO:0006000)4.11524971
61positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.10933965
62muscle system process (GO:0003012)4.06990288
63carnitine transport (GO:0015879)4.05923813
64amino-acid betaine transport (GO:0015838)4.05923813
65regulation of sulfur metabolic process (GO:0042762)4.04389460
66regulation of membrane repolarization (GO:0060306)4.03589338
67muscle hypertrophy (GO:0014896)4.00029628
68heart trabecula formation (GO:0060347)3.96217516
69glycogen metabolic process (GO:0005977)3.95870280
70ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.91361461
71gluconeogenesis (GO:0006094)3.90156636
72response to muscle activity (GO:0014850)3.89442582
73positive regulation of myotube differentiation (GO:0010831)3.88273479
74glucan metabolic process (GO:0044042)3.88114848
75cellular glucan metabolic process (GO:0006073)3.88114848
76cellular polysaccharide catabolic process (GO:0044247)3.85013343
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.84231593
78response to activity (GO:0014823)3.79974311
79muscle organ morphogenesis (GO:0048644)3.79516064
802-oxoglutarate metabolic process (GO:0006103)3.78089718
81muscle cell fate commitment (GO:0042693)3.77027858
82NADH metabolic process (GO:0006734)3.76552532
83muscle adaptation (GO:0043500)3.76249539
84regulation of calcium ion transmembrane transport (GO:1903169)3.72781001
85regulation of calcium ion transmembrane transporter activity (GO:1901019)3.72781001
86striated muscle cell development (GO:0055002)3.72693089
87muscle organ development (GO:0007517)3.71878482
88muscle structure development (GO:0061061)3.71858454
89negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.67001396
90negative regulation of calcium ion transmembrane transport (GO:1903170)3.67001396
91pyrimidine ribonucleoside catabolic process (GO:0046133)3.63308723
92polysaccharide catabolic process (GO:0000272)3.62435329
93muscle fiber development (GO:0048747)3.62213603
94positive regulation of cation channel activity (GO:2001259)3.59506061
95glucan biosynthetic process (GO:0009250)3.58544099
96glycogen biosynthetic process (GO:0005978)3.58544099
97cardiac muscle adaptation (GO:0014887)3.58018731
98cardiac muscle hypertrophy in response to stress (GO:0014898)3.58018731
99muscle hypertrophy in response to stress (GO:0003299)3.58018731
100hexose biosynthetic process (GO:0019319)3.48133680
101regulation of the force of heart contraction (GO:0002026)3.45660529
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45355559
103regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.45277239
104regulation of sequestering of triglyceride (GO:0010889)3.43124595
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42698514
106myoblast fusion (GO:0007520)3.40652350
107skeletal muscle tissue regeneration (GO:0043403)3.39924162
108oxidative phosphorylation (GO:0006119)3.39271116
109respiratory electron transport chain (GO:0022904)3.38645523
110neuronal action potential propagation (GO:0019227)3.38531002
111positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.38462256
112cell communication involved in cardiac conduction (GO:0086065)3.38421723
113relaxation of muscle (GO:0090075)3.34534269
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33729307
115muscle cell development (GO:0055001)3.31717813
116membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31099157
117cytidine metabolic process (GO:0046087)3.30664607
118cytidine catabolic process (GO:0006216)3.30664607
119cytidine deamination (GO:0009972)3.30664607
120regulation of ATP catabolic process (GO:1903289)3.29706913
121regulation of ATPase activity (GO:0043462)3.29706913
122cardiac muscle cell action potential involved in contraction (GO:0086002)3.28642555
123cardiac muscle cell action potential (GO:0086001)3.28569797
124IMP metabolic process (GO:0046040)3.28377486
125electron transport chain (GO:0022900)3.27544045
126negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24935202
127regulation of muscle system process (GO:0090257)3.23520784
128oxaloacetate metabolic process (GO:0006107)3.22237697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.72034136
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.59074404
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.97104757
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.88672659
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.87906408
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.70341364
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.70341364
8ESR1_20079471_ChIP-ChIP_T-47D_Human3.36700866
9ZNF263_19887448_ChIP-Seq_K562_Human2.90843987
10MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.69980347
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53163939
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41266724
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.35757633
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24563191
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.23871637
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20946311
17EZH2_22144423_ChIP-Seq_EOC_Human2.18671086
18GATA4_21415370_ChIP-Seq_HL-1_Mouse2.07115223
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99923284
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84517754
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82206082
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.74795083
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70239552
24BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.63978768
25CLOCK_20551151_ChIP-Seq_293T_Human1.63780310
26NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.53559125
27* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52241744
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52020610
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51379161
30CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47566690
31DROSHA_22980978_ChIP-Seq_HELA_Human1.44185344
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38983882
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37975938
34CTCF_27219007_Chip-Seq_Bcells_Human1.37535112
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29314386
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.28362687
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25402016
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25291579
39* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24762381
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24525266
41STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24050332
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20658825
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.20176610
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19634526
45ZNF274_21170338_ChIP-Seq_K562_Hela1.19565927
46KDM2B_26808549_Chip-Seq_DND41_Human1.18991821
47* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.18409993
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16937243
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13417940
50GATA1_19941826_ChIP-Seq_K562_Human1.11793543
51MYC_27129775_Chip-Seq_CORNEA_Mouse1.10549422
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08867958
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.08585247
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07168476
55CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07135265
56FOXH1_21741376_ChIP-Seq_ESCs_Human1.04561512
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04483471
58TP63_22573176_ChIP-Seq_HFKS_Human1.03953666
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03237259
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01368640
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.01301196
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01114762
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01058675
64LXR_22292898_ChIP-Seq_THP-1_Human1.01013196
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.00947184
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97519017
67OCT4_20526341_ChIP-Seq_ESCs_Human0.97210969
68DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96689447
69SPI1_20517297_ChIP-Seq_HL60_Human0.96350894
70RACK7_27058665_Chip-Seq_MCF-7_Human0.96321304
71GATA1_22025678_ChIP-Seq_K562_Human0.95419156
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95261895
73FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94336101
74ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93242787
75FOXA2_19822575_ChIP-Seq_HepG2_Human0.92716389
76IGF1R_20145208_ChIP-Seq_DFB_Human0.92481260
77RUNX1_27514584_Chip-Seq_MCF-7_Human0.91715866
78ATF3_27146783_Chip-Seq_COLON_Human0.89775128
79CREB1_26743006_Chip-Seq_LNCaP_Human0.89074965
80CRX_20693478_ChIP-Seq_RETINA_Mouse0.88844770
81SOX2_21211035_ChIP-Seq_LN229_Gbm0.88790055
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88590510
83ISL1_27105846_Chip-Seq_CPCs_Mouse0.88307677
84SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88121088
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87974993
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87871196
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87184555
88P68_20966046_ChIP-Seq_HELA_Human0.86700774
89SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86167996
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86101361
91GATA2_19941826_ChIP-Seq_K562_Human0.86002709
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85640243
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84916026
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84783154
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84081737
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83961559
97RARB_27405468_Chip-Seq_BRAIN_Mouse0.83706572
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.82969256
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82375304
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81533949
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81493056
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81443141
103HIF1A_21447827_ChIP-Seq_MCF-7_Human0.81424634
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80596646
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80394888
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.80126868
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.80044494
108MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79966310
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79887865
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79363125
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.78927522
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.78688233
113OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78487536
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78397710
115AR_21572438_ChIP-Seq_LNCaP_Human0.78349495
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78127464
117* CJUN_26792858_Chip-Seq_BT549_Human0.77915147
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77515002
119CTCF_21964334_Chip-Seq_Bcells_Human0.77476681
120SA1_27219007_Chip-Seq_Bcells_Human0.77416154
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.77392563
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77226480
123NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77102737
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76211484
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.76123988
126JARID2_20075857_ChIP-Seq_MESCs_Mouse0.75934123
127DPY_21335234_ChIP-Seq_ESCs_Mouse0.75885395
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74208955
129GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73040405
130EGR1_19032775_ChIP-ChIP_M12_Human0.72271590
131TCF7_22412390_ChIP-Seq_EML_Mouse0.71999129
132GATA6_21074721_ChIP-Seq_CACO-2_Human0.70226638
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70152082
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70152082
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.69739660
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.69001555
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.69001555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.31490563
2MP0002837_dystrophic_cardiac_calcinosis6.15778976
3MP0000751_myopathy5.54565297
4MP0000749_muscle_degeneration4.93706705
5MP0004145_abnormal_muscle_electrophysio4.78524287
6MP0004084_abnormal_cardiac_muscle4.50730814
7MP0004036_abnormal_muscle_relaxation4.39402868
8MP0004215_abnormal_myocardial_fiber3.65837339
9MP0004087_abnormal_muscle_fiber3.37496221
10MP0002106_abnormal_muscle_physiology3.28160615
11MP0005330_cardiomyopathy3.26135504
12MP0004130_abnormal_muscle_cell3.17889057
13MP0000750_abnormal_muscle_regeneration3.03952102
14MP0002269_muscular_atrophy3.02565856
15MP0005620_abnormal_muscle_contractility2.96608127
16MP0000747_muscle_weakness2.94614609
17MP0000759_abnormal_skeletal_muscle2.76451716
18MP0005369_muscle_phenotype2.70254598
19MP0002972_abnormal_cardiac_muscle2.59911582
20MP0004233_abnormal_muscle_weight2.26719265
21MP0003137_abnormal_impulse_conducting2.25347934
22MP0010630_abnormal_cardiac_muscle2.18687669
23MP0004484_altered_response_of2.15484132
24MP0008775_abnormal_heart_ventricle2.13786408
25MP0001544_abnormal_cardiovascular_syste2.08688127
26MP0005385_cardiovascular_system_phenoty2.08688127
27MP0006036_abnormal_mitochondrial_physio1.91783073
28MP0003221_abnormal_cardiomyocyte_apopto1.82887208
29MP0006138_congestive_heart_failure1.78132698
30MP0002332_abnormal_exercise_endurance1.78126236
31MP0003828_pulmonary_edema1.61505163
32MP0004085_abnormal_heartbeat1.56461330
33MP0004510_myositis1.56320166
34MP0005666_abnormal_adipose_tissue1.55433111
35MP0004185_abnormal_adipocyte_glucose1.39828454
36MP0002108_abnormal_muscle_morphology1.35181119
37MP0005670_abnormal_white_adipose1.34570042
38MP0002127_abnormal_cardiovascular_syste1.33270907
39MP0000733_abnormal_muscle_development1.20458635
40MP0003950_abnormal_plasma_membrane1.16852030
41MP0005375_adipose_tissue_phenotype1.11873738
42MP0002234_abnormal_pharynx_morphology1.01535815
43MP0000343_altered_response_to1.01322794
44MP0006035_abnormal_mitochondrial_morpho0.99671790
45MP0001661_extended_life_span0.99073227
46MP0000266_abnormal_heart_morphology0.96054065
47MP0005266_abnormal_metabolism0.93434751
48MP0000013_abnormal_adipose_tissue0.88171114
49MP0003567_abnormal_fetal_cardiomyocyte0.87037540
50MP0003806_abnormal_nucleotide_metabolis0.85046145
51MP0002971_abnormal_brown_adipose0.84280425
52MP0005165_increased_susceptibility_to0.78019758
53MP0004043_abnormal_pH_regulation0.71370484
54MP0000230_abnormal_systemic_arterial0.69452238
55MP0003705_abnormal_hypodermis_morpholog0.68724263
56MP0000003_abnormal_adipose_tissue0.67503688
57MP0003279_aneurysm0.67409678
58MP0004147_increased_porphyrin_level0.62837128
59MP0002078_abnormal_glucose_homeostasis0.61419178
60MP0002128_abnormal_blood_circulation0.59833627
61MP0002909_abnormal_adrenal_gland0.59525070
62MP0005334_abnormal_fat_pad0.57385691
63MP0000372_irregular_coat_pigmentation0.56871769
64MP0008961_abnormal_basal_metabolism0.55436729
65MP0003879_abnormal_hair_cell0.53435828
66MP0010368_abnormal_lymphatic_system0.50654455
67MP0004134_abnormal_chest_morphology0.47534700
68MP0005319_abnormal_enzyme/_coenzyme0.47247798
69MP0003566_abnormal_cell_adhesion0.45575286
70MP0005623_abnormal_meninges_morphology0.45130510
71MP0009840_abnormal_foam_cell0.42978021
72MP0005187_abnormal_penis_morphology0.41368918
73MP0002638_abnormal_pupillary_reflex0.41191544
74MP0010030_abnormal_orbit_morphology0.39677525
75MP0001346_abnormal_lacrimal_gland0.38352708
76MP0000767_abnormal_smooth_muscle0.38206954
77MP0005167_abnormal_blood-brain_barrier0.38171718
78MP0005535_abnormal_body_temperature0.38119902
79MP0001879_abnormal_lymphatic_vessel0.38028116
80MP0003656_abnormal_erythrocyte_physiolo0.36717920
81MP0004270_analgesia0.35456199
82MP0005584_abnormal_enzyme/coenzyme_acti0.35101209
83MP0001299_abnormal_eye_distance/0.34971935
84MP0003045_fibrosis0.34431448
85MP0003195_calcinosis0.34035636
86MP0005166_decreased_susceptibility_to0.33778513
87MP0005451_abnormal_body_composition0.33655519
88MP0005275_abnormal_skin_tensile0.32559335
89MP0002118_abnormal_lipid_homeostasis0.32013857
90MP0005083_abnormal_biliary_tract0.31162187
91MP0002925_abnormal_cardiovascular_devel0.30992917
92MP0009672_abnormal_birth_weight0.30876670
93MP0004142_abnormal_muscle_tone0.30782851
94MP0002114_abnormal_axial_skeleton0.30021466
95MP0003948_abnormal_gas_homeostasis0.29959584
96MP0005452_abnormal_adipose_tissue0.29442899
97MP0009780_abnormal_chondrocyte_physiolo0.28702153
98MP0005423_abnormal_somatic_nervous0.28335678
99MP0005332_abnormal_amino_acid0.28058764
100MP0009115_abnormal_fat_cell0.27511015
101MP0008438_abnormal_cutaneous_collagen0.26800598
102MP0008569_lethality_at_weaning0.26526729
103MP0009250_abnormal_appendicular_skeleto0.26223142
104MP0001614_abnormal_blood_vessel0.23716376
105MP0001784_abnormal_fluid_regulation0.21848552
106MP0005376_homeostasis/metabolism_phenot0.21052363
107MP0002066_abnormal_motor_capabilities/c0.20550603
108MP0002896_abnormal_bone_mineralization0.20515186
109MP0002734_abnormal_mechanical_nocicepti0.20204847
110MP0002822_catalepsy0.19623303
111MP0001943_abnormal_respiration0.19493608
112MP0000762_abnormal_tongue_morphology0.19216664
113MP0004924_abnormal_behavior0.18219516
114MP0005386_behavior/neurological_phenoty0.18219516
115MP0001853_heart_inflammation0.17526769
116MP0008874_decreased_physiological_sensi0.17238905
117MP0004272_abnormal_basement_membrane0.16904591
118MP0001727_abnormal_embryo_implantation0.16838597
119MP0004858_abnormal_nervous_system0.16188130
120MP0003959_abnormal_lean_body0.15381096

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.83748392
2Exercise-induced muscle cramps (HP:0003710)7.39472663
3Muscle hypertrophy of the lower extremities (HP:0008968)7.08372833
4Calf muscle hypertrophy (HP:0008981)7.02519832
5Muscle fiber inclusion bodies (HP:0100299)6.35253689
6Sudden death (HP:0001699)6.28617064
7Muscle fiber splitting (HP:0003555)6.23404331
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.19820503
9Myoglobinuria (HP:0002913)5.68934223
10Hyporeflexia of lower limbs (HP:0002600)5.42800243
11Nemaline bodies (HP:0003798)5.35944743
12Abnormality of the calf musculature (HP:0001430)5.27515836
13Ventricular tachycardia (HP:0004756)5.06478322
14Type 1 muscle fiber predominance (HP:0003803)4.99370823
15Difficulty running (HP:0009046)4.93795915
16Abnormality of the left ventricular outflow tract (HP:0011103)4.91313436
17Subaortic stenosis (HP:0001682)4.91313436
18EMG: myopathic abnormalities (HP:0003458)4.86307666
19Rhabdomyolysis (HP:0003201)4.50297934
20Increased connective tissue (HP:0009025)4.49786031
21Myotonia (HP:0002486)4.12572921
22Atrial fibrillation (HP:0005110)4.07465283
23Distal arthrogryposis (HP:0005684)4.05129783
24Lipoatrophy (HP:0100578)4.04153505
25Muscle stiffness (HP:0003552)4.00883500
26Asymmetric septal hypertrophy (HP:0001670)3.98524014
27Myopathic facies (HP:0002058)3.82471710
28Primary atrial arrhythmia (HP:0001692)3.81234833
29Supraventricular tachycardia (HP:0004755)3.67646264
30Supraventricular arrhythmia (HP:0005115)3.59535327
31Round ear (HP:0100830)3.55149700
32Right ventricular cardiomyopathy (HP:0011663)3.48175629
33Difficulty climbing stairs (HP:0003551)3.47105946
34Dilated cardiomyopathy (HP:0001644)3.43755293
35Bundle branch block (HP:0011710)3.35851428
36Palpitations (HP:0001962)3.19934570
37Increased variability in muscle fiber diameter (HP:0003557)3.16231278
38Syncope (HP:0001279)3.15938330
39Abnormality of skeletal muscle fiber size (HP:0012084)3.15178203
40Ulnar deviation of the wrist (HP:0003049)3.13941341
41Rimmed vacuoles (HP:0003805)3.13134737
42Neck muscle weakness (HP:0000467)3.12642036
43Areflexia of lower limbs (HP:0002522)3.09289881
44Prolonged QT interval (HP:0001657)3.03402885
45Ventricular arrhythmia (HP:0004308)2.92887318
46Distal lower limb muscle weakness (HP:0009053)2.78161895
47Heart block (HP:0012722)2.77545001
48Abnormal atrioventricular conduction (HP:0005150)2.61450029
49Bulbar palsy (HP:0001283)2.55598342
50Atrioventricular block (HP:0001678)2.52258747
51Calcaneovalgus deformity (HP:0001848)2.51909391
52Limb-girdle muscle atrophy (HP:0003797)2.51082958
53Weak cry (HP:0001612)2.46334495
54Absent phalangeal crease (HP:0006109)2.46173747
55Muscular dystrophy (HP:0003560)2.43145697
56Ventricular fibrillation (HP:0001663)2.43130466
57Slender build (HP:0001533)2.41502681
58EMG: neuropathic changes (HP:0003445)2.38647734
59Hypoplastic ischia (HP:0003175)2.37433742
60Left ventricular hypertrophy (HP:0001712)2.34146752
61Frequent falls (HP:0002359)2.29419171
62Ketoacidosis (HP:0001993)2.26795335
63Abnormality of the calcaneus (HP:0008364)2.25724384
64Deformed tarsal bones (HP:0008119)2.23387371
65Distal lower limb amyotrophy (HP:0008944)2.22928946
66Abnormal EKG (HP:0003115)2.21582703
67Fetal akinesia sequence (HP:0001989)2.20886422
68Hyperkalemia (HP:0002153)2.20847332
69Mildly elevated creatine phosphokinase (HP:0008180)2.18979582
70Facial diplegia (HP:0001349)2.17075385
71Abnormal mitochondria in muscle tissue (HP:0008316)2.14931508
72Limb-girdle muscle weakness (HP:0003325)2.13822746
73Generalized muscle weakness (HP:0003324)2.13727148
74Proximal amyotrophy (HP:0007126)2.10435043
75Hepatic necrosis (HP:0002605)2.10400407
76Gowers sign (HP:0003391)2.09773598
77Ragged-red muscle fibers (HP:0003200)2.09651238
78Hip contracture (HP:0003273)2.09548449
79Abnormality of the ischium (HP:0003174)2.08336440
80Acute necrotizing encephalopathy (HP:0006965)2.08129088
81Testicular atrophy (HP:0000029)2.05012967
82Waddling gait (HP:0002515)2.02268795
83Scapular winging (HP:0003691)1.99953236
84Abnormality of the hip-girdle musculature (HP:0001445)1.99176671
85Abnormality of the musculature of the pelvis (HP:0001469)1.99176671
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98556023
87Abnormal finger flexion creases (HP:0006143)1.96963873
88Increased muscle lipid content (HP:0009058)1.96719422
89Exercise intolerance (HP:0003546)1.94851794
90Malignant hyperthermia (HP:0002047)1.94481914
91Palmoplantar keratoderma (HP:0000982)1.93897228
92Shoulder girdle muscle weakness (HP:0003547)1.93605194
93Lower limb amyotrophy (HP:0007210)1.93134525
94Pelvic girdle muscle weakness (HP:0003749)1.91870434
95Progressive muscle weakness (HP:0003323)1.88907281
96Hepatocellular necrosis (HP:0001404)1.84399524
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.83927453
98Hypoglycemic coma (HP:0001325)1.81948878
99Acute encephalopathy (HP:0006846)1.81643856
100Large for gestational age (HP:0001520)1.81317824
101Abnormality of the foot musculature (HP:0001436)1.80614143
102Respiratory insufficiency due to muscle weakness (HP:0002747)1.79890914
103Foot dorsiflexor weakness (HP:0009027)1.78067851
104Fatigable weakness (HP:0003473)1.77505552
105Abnormality of the neuromuscular junction (HP:0003398)1.77505552
106Cholelithiasis (HP:0001081)1.76630632
107Abnormality of fatty-acid metabolism (HP:0004359)1.72118579
108Abnormality of the shoulder girdle musculature (HP:0001435)1.71762484
109Spinal rigidity (HP:0003306)1.71596461
110Ketosis (HP:0001946)1.70871461
111Increased intramyocellular lipid droplets (HP:0012240)1.67509362
112Paralysis (HP:0003470)1.65312686
113Nonprogressive disorder (HP:0003680)1.57656580
114Metatarsus adductus (HP:0001840)1.51331331
115Long clavicles (HP:0000890)1.44853980
116Ulnar deviation of finger (HP:0009465)1.44815958
117Popliteal pterygium (HP:0009756)1.42284600
118Steppage gait (HP:0003376)1.40045832
119Limited hip movement (HP:0008800)1.38727752
120Type 2 muscle fiber atrophy (HP:0003554)1.36026670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.68228362
2OBSCN6.33670176
3PHKG25.18893854
4PHKG15.18893854
5PDK32.87633774
6PDK42.87633774
7DMPK2.83817787
8NME12.72517183
9TRIB32.44774780
10MYLK2.29394238
11NEK12.28592173
12LMTK22.27122426
13BCKDK2.16869294
14PKN22.13298954
15PINK12.12940828
16PIK3CA2.11769804
17MUSK1.87507677
18MAP2K31.80436987
19PDK21.79213974
20PIK3CG1.76974615
21MAP3K71.63222998
22MAPK121.42327271
23STK241.30087256
24TIE11.21685145
25GRK71.07880655
26MARK11.05093510
27EEF2K1.02567851
28PRKAA21.02510814
29MAP2K41.02293505
30PRKAA11.00443417
31LIMK10.91975192
32TRPM70.91346993
33PRKD10.90180602
34ILK0.88091633
35CAMK2D0.87890831
36MAPKAPK30.87434085
37ZAK0.85470040
38PAK30.82159447
39MOS0.81653771
40INSRR0.78084641
41DYRK1B0.76419007
42PKN10.75128170
43RIPK10.74673502
44CCNB10.73813173
45TGFBR20.70306847
46ERBB30.67831743
47ROCK10.67758487
48MAP3K30.66166376
49MAP2K60.65951117
50NEK90.65800420
51EPHB10.62477061
52MAP3K50.61404943
53MAP3K130.58542491
54SIK10.52641214
55CDC42BPA0.48418803
56FLT30.47836734
57MAP2K10.47110371
58PTK60.46102180
59CAMK40.45680451
60PRKACB0.45346634
61PDGFRA0.45209941
62CAMK2G0.45143135
63WNK40.44859612
64CAMK2B0.44165650
65AKT20.43118806
66LATS20.40045125
67WNK10.39553340
68CAMK2A0.39012798
69PTK2B0.38592794
70STK38L0.36481821
71STK40.36160063
72ROCK20.35117226
73DAPK30.35026122
74PRKACA0.34281862
75CAMK10.33904000
76RPS6KC10.33215189
77RPS6KL10.33215189
78MAPK110.32337177
79ICK0.31054923
80PDPK10.30453170
81SGK20.30372116
82PRKACG0.29796910
83TBK10.29635683
84STK380.29509917
85SGK10.27906172
86MAPK70.26821038
87RPS6KA60.26385865
88PDK10.26266181
89CAMK1G0.25806011
90PRPF4B0.25761125
91PRKG10.25603163
92SGK30.24025930
93MAP3K40.23345856
94RPS6KA30.23143088
95MAPK100.22362932
96RPS6KB10.22327053
97RPS6KA10.22018851
98PRKCH0.20950821
99MAP3K10.19609136
100ARAF0.18210912
101MAP3K110.17805450
102MAP3K60.17424682
103MAPK130.17230643
104MARK20.16997506
105TAOK10.16930842
106MTOR0.16705826
107RET0.16483470
108KDR0.16156959
109TYK20.16061331
110RPS6KB20.14895596
111PRKD30.14362227
112MARK30.13766030
113TAOK20.13738078
114PRKCE0.13532247
115JAK10.13497696
116ZAP700.12998623
117PAK60.12938618
118RPS6KA20.12936815
119SGK2230.12574258
120SGK4940.12574258
121DAPK20.12436299
122JAK20.11304976
123STK110.10905287
124MAPK40.09915750
125FER0.09282499
126KSR20.07534034
127RAF10.07317664
128LATS10.06151913
129CDK190.04390293
130MAPK90.04209364
131MAP3K100.03724321

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.50529030
2Cardiac muscle contraction_Homo sapiens_hsa042604.18124317
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.11425121
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.97631415
5Dilated cardiomyopathy_Homo sapiens_hsa054143.79269565
6Propanoate metabolism_Homo sapiens_hsa006403.07038630
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06352106
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.90026237
9Parkinsons disease_Homo sapiens_hsa050122.66475955
10Oxidative phosphorylation_Homo sapiens_hsa001902.52741097
11Fatty acid degradation_Homo sapiens_hsa000712.45249342
12Carbon metabolism_Homo sapiens_hsa012002.36284408
13Alzheimers disease_Homo sapiens_hsa050102.09687711
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05995495
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96227640
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.85715240
17Fatty acid metabolism_Homo sapiens_hsa012121.85518408
18Viral myocarditis_Homo sapiens_hsa054161.73447282
19Pyruvate metabolism_Homo sapiens_hsa006201.72892223
20Starch and sucrose metabolism_Homo sapiens_hsa005001.65285809
21Glucagon signaling pathway_Homo sapiens_hsa049221.52859325
22Huntingtons disease_Homo sapiens_hsa050161.50023777
23Insulin resistance_Homo sapiens_hsa049311.46658459
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42751671
25Insulin signaling pathway_Homo sapiens_hsa049101.39413580
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33987142
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.31469293
28Oxytocin signaling pathway_Homo sapiens_hsa049211.22928744
29Biosynthesis of amino acids_Homo sapiens_hsa012301.18430317
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12079601
31Circadian rhythm_Homo sapiens_hsa047101.11649835
32Calcium signaling pathway_Homo sapiens_hsa040201.11335920
33AMPK signaling pathway_Homo sapiens_hsa041521.08471763
34Butanoate metabolism_Homo sapiens_hsa006501.06946573
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96601623
36PPAR signaling pathway_Homo sapiens_hsa033200.94892375
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90818073
38Galactose metabolism_Homo sapiens_hsa000520.89680107
39Fatty acid elongation_Homo sapiens_hsa000620.86770809
40Fructose and mannose metabolism_Homo sapiens_hsa000510.84300333
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.81368549
42Arginine biosynthesis_Homo sapiens_hsa002200.81111367
43Focal adhesion_Homo sapiens_hsa045100.78232463
44Nitrogen metabolism_Homo sapiens_hsa009100.77934388
45Long-term potentiation_Homo sapiens_hsa047200.77648883
46Arginine and proline metabolism_Homo sapiens_hsa003300.77535090
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74873771
48Type II diabetes mellitus_Homo sapiens_hsa049300.73152050
49Tight junction_Homo sapiens_hsa045300.70826795
50HIF-1 signaling pathway_Homo sapiens_hsa040660.69950734
51Gastric acid secretion_Homo sapiens_hsa049710.69142389
52Tryptophan metabolism_Homo sapiens_hsa003800.63005793
53beta-Alanine metabolism_Homo sapiens_hsa004100.60877657
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60328780
55Renin secretion_Homo sapiens_hsa049240.60003996
56Lysine degradation_Homo sapiens_hsa003100.57079154
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.57030338
58Fatty acid biosynthesis_Homo sapiens_hsa000610.56818533
59Insulin secretion_Homo sapiens_hsa049110.56629885
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50953857
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47290245
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46570366
63Phenylalanine metabolism_Homo sapiens_hsa003600.43247482
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43099202
65GnRH signaling pathway_Homo sapiens_hsa049120.42018186
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41276353
67FoxO signaling pathway_Homo sapiens_hsa040680.38489267
68Peroxisome_Homo sapiens_hsa041460.38132485
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37216399
70mTOR signaling pathway_Homo sapiens_hsa041500.36704133
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35166904
72cAMP signaling pathway_Homo sapiens_hsa040240.35025514
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33765552
74Amoebiasis_Homo sapiens_hsa051460.33247547
75Adherens junction_Homo sapiens_hsa045200.32687619
76Circadian entrainment_Homo sapiens_hsa047130.31097685
77Amphetamine addiction_Homo sapiens_hsa050310.29117786
78Platelet activation_Homo sapiens_hsa046110.28691338
79VEGF signaling pathway_Homo sapiens_hsa043700.28340998
80Histidine metabolism_Homo sapiens_hsa003400.26572195
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25791047
82Renal cell carcinoma_Homo sapiens_hsa052110.25256428
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25081480
84ECM-receptor interaction_Homo sapiens_hsa045120.24439333
85Long-term depression_Homo sapiens_hsa047300.24298558
86MAPK signaling pathway_Homo sapiens_hsa040100.23883732
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.23755041
88Regulation of autophagy_Homo sapiens_hsa041400.21767667
89Melanogenesis_Homo sapiens_hsa049160.20514784
90Pentose phosphate pathway_Homo sapiens_hsa000300.20324703
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18411013
92Cholinergic synapse_Homo sapiens_hsa047250.17923031
93Proteoglycans in cancer_Homo sapiens_hsa052050.15614453
94Purine metabolism_Homo sapiens_hsa002300.15512349
95Metabolic pathways_Homo sapiens_hsa011000.15338498
96Pancreatic secretion_Homo sapiens_hsa049720.15271322
97Glioma_Homo sapiens_hsa052140.14237159
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12593832
99Dorso-ventral axis formation_Homo sapiens_hsa043200.11789153
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.11757074
101Sulfur relay system_Homo sapiens_hsa041220.11186023
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.09386757
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09327816
104Fat digestion and absorption_Homo sapiens_hsa049750.09040733
105Gap junction_Homo sapiens_hsa045400.08789027
106Bile secretion_Homo sapiens_hsa049760.08607177
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08389771
108Oocyte meiosis_Homo sapiens_hsa041140.08097126
109Tyrosine metabolism_Homo sapiens_hsa003500.08009257
110Salivary secretion_Homo sapiens_hsa049700.06842799
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.05601125
112Toxoplasmosis_Homo sapiens_hsa051450.03709042
113Olfactory transduction_Homo sapiens_hsa047400.03636147
114Ovarian steroidogenesis_Homo sapiens_hsa049130.03336271
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02643555
116ABC transporters_Homo sapiens_hsa020100.02058996

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