KLHL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)6.34605880
2central nervous system myelination (GO:0022010)6.03763814
3axon ensheathment in central nervous system (GO:0032291)6.03763814
4skin morphogenesis (GO:0043589)4.92821219
5L-amino acid import (GO:0043092)4.61861803
6substrate-dependent cell migration (GO:0006929)4.58539744
7fatty acid elongation (GO:0030497)4.50370243
8myelination (GO:0042552)4.37325225
9ensheathment of neurons (GO:0007272)4.35843130
10axon ensheathment (GO:0008366)4.35843130
11endodermal cell differentiation (GO:0035987)4.32343448
12amino acid import (GO:0043090)4.31914296
13mesodermal cell differentiation (GO:0048333)4.18116472
14activated T cell proliferation (GO:0050798)4.07309540
15chondrocyte proliferation (GO:0035988)4.03840537
16neuron cell-cell adhesion (GO:0007158)3.99843383
17hypotonic response (GO:0006971)3.91761057
18wound healing, spreading of epidermal cells (GO:0035313)3.67562876
19response to methylmercury (GO:0051597)3.57187081
20hemidesmosome assembly (GO:0031581)3.52182737
21locomotory exploration behavior (GO:0035641)3.42514444
22regulation of glucose import in response to insulin stimulus (GO:2001273)3.35066733
23positive regulation of osteoblast proliferation (GO:0033690)3.30895903
24regulation of transforming growth factor beta2 production (GO:0032909)3.30418306
25cell-substrate junction assembly (GO:0007044)3.28091956
26collagen fibril organization (GO:0030199)3.27298756
27cholesterol biosynthetic process (GO:0006695)3.26491321
28COPI coating of Golgi vesicle (GO:0048205)3.22740344
29Golgi transport vesicle coating (GO:0048200)3.22740344
30muscle cell migration (GO:0014812)3.18696210
31heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.18497986
32presynaptic membrane assembly (GO:0097105)3.17942143
33pericardium development (GO:0060039)3.15148052
34negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.12542891
35long-chain fatty acid biosynthetic process (GO:0042759)3.11958241
36endothelial cell morphogenesis (GO:0001886)3.11080767
37regulation of collateral sprouting (GO:0048670)3.09836811
38long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08738320
39protein heterotrimerization (GO:0070208)3.06774274
40SMAD protein complex assembly (GO:0007183)3.06721149
41membrane assembly (GO:0071709)3.05634408
42cellular response to vitamin (GO:0071295)3.04893002
43negative regulation of fibrinolysis (GO:0051918)3.04617660
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03663771
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02600881
46vascular endothelial growth factor signaling pathway (GO:0038084)3.00991634
47neuron projection extension involved in neuron projection guidance (GO:1902284)3.00981656
48axon extension involved in axon guidance (GO:0048846)3.00981656
49fibrinolysis (GO:0042730)3.00769058
50regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.00148155
51wound healing, spreading of cells (GO:0044319)2.99447543
52eye photoreceptor cell differentiation (GO:0001754)2.99324825
53photoreceptor cell differentiation (GO:0046530)2.99324825
54peptidyl-tyrosine autophosphorylation (GO:0038083)2.99306743
55myelin maintenance (GO:0043217)2.98773860
56neuron remodeling (GO:0016322)2.98594556
57negative regulation of chondrocyte differentiation (GO:0032331)2.96211578
58Rap protein signal transduction (GO:0032486)2.95124436
59import into cell (GO:0098657)2.94267293
60positive regulation of extracellular matrix organization (GO:1903055)2.92851054
61oligodendrocyte differentiation (GO:0048709)2.92333156
62negative regulation of fatty acid transport (GO:2000192)2.91862109
63positive regulation of endothelial cell apoptotic process (GO:2000353)2.91390152
64basement membrane organization (GO:0071711)2.90287455
65apoptotic cell clearance (GO:0043277)2.90194398
66COPII vesicle coating (GO:0048208)2.89276037
67mesenchymal-epithelial cell signaling (GO:0060638)2.89054134
68protein maturation by protein folding (GO:0022417)2.88508399
69myelination in peripheral nervous system (GO:0022011)2.87760129
70peripheral nervous system axon ensheathment (GO:0032292)2.87760129
71negative regulation of neurotransmitter secretion (GO:0046929)2.86486323
72cellular response to epinephrine stimulus (GO:0071872)2.86243782
73collagen metabolic process (GO:0032963)2.85253330
74presynaptic membrane organization (GO:0097090)2.85209666
75dermatan sulfate biosynthetic process (GO:0030208)2.83289829
76cellular response to vitamin D (GO:0071305)2.82995370
77long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.82750486
78lung vasculature development (GO:0060426)2.82206218
79glomerular basement membrane development (GO:0032836)2.80215573
80sterol biosynthetic process (GO:0016126)2.79956809
81fatty-acyl-CoA biosynthetic process (GO:0046949)2.79471496
82positive regulation of focal adhesion assembly (GO:0051894)2.78708091
83positive regulation of cell junction assembly (GO:1901890)2.78708091
84negative regulation of anoikis (GO:2000811)2.78490585
85vesicle coating (GO:0006901)2.78215246
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77850513
87sprouting angiogenesis (GO:0002040)2.77049770
88smooth muscle tissue development (GO:0048745)2.76727460
89positive regulation of blood coagulation (GO:0030194)2.74352063
90positive regulation of hemostasis (GO:1900048)2.74352063
91stress fiber assembly (GO:0043149)2.72323053
92virion attachment to host cell (GO:0019062)2.72306951
93adhesion of symbiont to host cell (GO:0044650)2.72306951
94regulation of osteoblast proliferation (GO:0033688)2.71925560
95substrate adhesion-dependent cell spreading (GO:0034446)2.71745039
96negative regulation of protein localization to cell surface (GO:2000009)2.71362168
97nerve growth factor signaling pathway (GO:0038180)2.70489028
98collagen catabolic process (GO:0030574)2.70206174
99glomerular filtration (GO:0003094)2.68814267
100positive regulation of adherens junction organization (GO:1903393)2.68516074
101dendrite morphogenesis (GO:0048813)2.68481874
102semaphorin-plexin signaling pathway (GO:0071526)2.68357585
103positive regulation of muscle hypertrophy (GO:0014742)2.68267382
104positive regulation of cardiac muscle hypertrophy (GO:0010613)2.68267382
105negative regulation of axon extension (GO:0030517)2.68096778
106positive regulation of receptor recycling (GO:0001921)2.67907839
107positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.66237849
108interleukin-6-mediated signaling pathway (GO:0070102)2.66225828
109protein retention in ER lumen (GO:0006621)2.65511050
110fatty-acyl-CoA metabolic process (GO:0035337)2.64041026
111response to epinephrine (GO:0071871)2.60810742
112cell migration involved in sprouting angiogenesis (GO:0002042)2.60694583
113type B pancreatic cell proliferation (GO:0044342)2.60500626
114platelet degranulation (GO:0002576)2.60431778
115regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.60220259
116negative regulation of neurotransmitter transport (GO:0051589)2.59214133
117multicellular organismal macromolecule metabolic process (GO:0044259)2.58905520
118isoprenoid biosynthetic process (GO:0008299)2.57738796
119dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57518260
120substantia nigra development (GO:0021762)2.57470806
121positive regulation of coagulation (GO:0050820)2.57465523
122C4-dicarboxylate transport (GO:0015740)2.57134633
123dermatan sulfate metabolic process (GO:0030205)2.57017162
124enteric nervous system development (GO:0048484)2.56462148
125barbed-end actin filament capping (GO:0051016)2.56386205
126response to lipoprotein particle (GO:0055094)2.56038899
127negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.56008963
128hippo signaling (GO:0035329)2.54598504
129very long-chain fatty acid metabolic process (GO:0000038)2.53143042
130axon extension (GO:0048675)2.51907641
131positive regulation of Rho protein signal transduction (GO:0035025)2.50805611
132L-serine transport (GO:0015825)2.50283477
133regulation of axon extension involved in axon guidance (GO:0048841)2.48414745
134positive regulation of epithelial cell migration (GO:0010634)2.48391197
135protein hydroxylation (GO:0018126)2.47999749
136transmission of nerve impulse (GO:0019226)2.47638017
137sensory perception of smell (GO:0007608)2.47280858
138negative regulation of axonogenesis (GO:0050771)2.46466094
139astrocyte development (GO:0014002)2.46126187
140regulation of smooth muscle cell migration (GO:0014910)2.46061074
141cell-matrix adhesion (GO:0007160)2.45031734
142positive regulation of wound healing (GO:0090303)2.44645134
143multicellular organismal metabolic process (GO:0044236)2.44285680
144negative regulation of osteoblast proliferation (GO:0033689)2.43983608
145heparan sulfate proteoglycan metabolic process (GO:0030201)2.43899551
146regulation of plasminogen activation (GO:0010755)2.43391714
147cell-substrate adherens junction assembly (GO:0007045)2.42578842
148focal adhesion assembly (GO:0048041)2.42578842
149neuron recognition (GO:0008038)2.42363526
150regulation of axon guidance (GO:1902667)2.41614951
151sequestering of extracellular ligand from receptor (GO:0035581)2.41203318
152extracellular matrix disassembly (GO:0022617)2.41093103
153peptidyl-glutamic acid carboxylation (GO:0017187)2.39935983
154protein carboxylation (GO:0018214)2.39935983
155adhesion of symbiont to host (GO:0044406)2.38862642
156cerebral cortex radially oriented cell migration (GO:0021799)2.38486730
157platelet-derived growth factor receptor signaling pathway (GO:0048008)2.38076485
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.38035564
159detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.38035564
160positive regulation of smooth muscle cell migration (GO:0014911)2.37846498
161cortical actin cytoskeleton organization (GO:0030866)2.36684220
162creatine metabolic process (GO:0006600)2.32118763
163renal filtration (GO:0097205)2.32055477
164regulation of neuron projection regeneration (GO:0070570)2.31767331
165regulation of axon regeneration (GO:0048679)2.31767331
166protein localization to endosome (GO:0036010)2.30060296
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.28425461
168membrane raft organization (GO:0031579)2.26982591
169blood vessel maturation (GO:0001955)2.26835803
170regulation of platelet aggregation (GO:0090330)2.26280263
171thioester biosynthetic process (GO:0035384)2.24457281
172acyl-CoA biosynthetic process (GO:0071616)2.24457281
173glycerophospholipid catabolic process (GO:0046475)2.21416191
174serine transport (GO:0032329)2.21224210
175cortical cytoskeleton organization (GO:0030865)2.20635675
176positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.20450321
177regulation of transmission of nerve impulse (GO:0051969)2.20210629
178amyloid precursor protein catabolic process (GO:0042987)2.18767430
179negative regulation of platelet activation (GO:0010544)2.18642841
180positive regulation of vasculogenesis (GO:2001214)2.18256665
181asymmetric protein localization (GO:0008105)2.18196885
182membrane protein ectodomain proteolysis (GO:0006509)2.15927495
183glycosylceramide metabolic process (GO:0006677)2.15916992
184regulation of vasculogenesis (GO:2001212)2.15909075
185axonal fasciculation (GO:0007413)2.14762734
186surfactant homeostasis (GO:0043129)2.14167840
187leukocyte migration involved in inflammatory response (GO:0002523)2.14094420
188positive regulation of lipid kinase activity (GO:0090218)2.11080312
189membrane tubulation (GO:0097320)2.10052038
190exploration behavior (GO:0035640)2.09691311
191L-glutamate transport (GO:0015813)2.09162508
192retina vasculature morphogenesis in camera-type eye (GO:0061299)2.08393086
193acidic amino acid transport (GO:0015800)2.07516773
194cellular response to catecholamine stimulus (GO:0071870)2.06561599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81388082
2BRD4_25478319_ChIP-Seq_HGPS_Human2.75183505
3GBX2_23144817_ChIP-Seq_PC3_Human2.71946494
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.67473932
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48498597
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35168261
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31081412
8AR_21572438_ChIP-Seq_LNCaP_Human2.24719781
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19999446
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.19274037
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17584585
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.17306235
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.17306235
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08707519
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08284382
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07673049
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06839111
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06839111
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06127908
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05276098
21SALL4_18804426_ChIP-ChIP_XEN_Mouse2.04786459
22EZH2_22144423_ChIP-Seq_EOC_Human2.02808069
23PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02004659
24CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.00977194
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95951789
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91835716
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.90042031
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.88746426
29TAF15_26573619_Chip-Seq_HEK293_Human1.85326803
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83222339
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.78088323
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76236512
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75371512
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69683944
35DROSHA_22980978_ChIP-Seq_HELA_Human1.68881414
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.68868344
37* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.68595248
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68408608
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64180703
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63159680
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62376029
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61356382
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60914670
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.59302364
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.54512777
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.53208881
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52913977
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51912742
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51362484
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50742070
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.49675961
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48942247
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.46221538
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44807621
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42382831
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41658230
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41417741
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.40755321
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40110046
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.39784154
61* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39053451
62ER_23166858_ChIP-Seq_MCF-7_Human1.38500805
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.38225069
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37717766
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36832187
66NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36724753
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36097382
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35822174
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35822174
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.34567078
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.33035305
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.32280344
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.31395838
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30373460
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29624925
76P300_19829295_ChIP-Seq_ESCs_Human1.28542938
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28034585
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27010575
79TP63_23658742_ChIP-Seq_EP156T_Human1.26317983
80VDR_24787735_ChIP-Seq_THP-1_Human1.25295779
81AHR_22903824_ChIP-Seq_MCF-7_Human1.24869019
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23914871
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23516804
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.23507505
85SMAD4_21799915_ChIP-Seq_A2780_Human1.21850085
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21168835
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20735575
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.20420296
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18905527
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17444613
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15674027
92ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14906048
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14858836
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14629422
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.13960301
96TP53_18474530_ChIP-ChIP_U2OS_Human1.12197432
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.11362613
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11173540
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10917983
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10744278
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.10573658
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10063056
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09682460
104* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09588704
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07989709
106RUNX_20019798_ChIP-Seq_JUKART_Human1.07385091
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07208910
108* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05144161
109AR_21909140_ChIP-Seq_LNCAP_Human1.04697916
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04185490
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03976491
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03934404
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03442017
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02977166
115UBF1/2_26484160_Chip-Seq_HMECs_Human1.02563190
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02529418
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02496033
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02467754
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02427301
120TP53_16413492_ChIP-PET_HCT116_Human1.02098636
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01865751
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01733314
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01539891
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.01490024
125JUN_21703547_ChIP-Seq_K562_Human1.00793737
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99911258
127NANOG_18555785_Chip-Seq_ESCs_Mouse0.99595177
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98989751
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98235757
130MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97962056
131PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97847162
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97752067
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97705579
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.95493359
135* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94895607
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94894606
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.94830962
138CJUN_26792858_Chip-Seq_BT549_Human0.94333043
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.93708829
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93069345
141RUNX2_22187159_ChIP-Seq_PCA_Human0.92779989
142STAT3_23295773_ChIP-Seq_U87_Human0.92227862
143* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91940593
144AR_25329375_ChIP-Seq_VCAP_Human0.91656354
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91346160
146* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91325041
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90327767
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88889868
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86930006
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86930006
151GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86694990
152LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85812892
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.85723632
154* SOX2_20726797_ChIP-Seq_SW620_Human0.85415896
155KDM2B_26808549_Chip-Seq_REH_Human0.85334049
156STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84964097
157CLOCK_20551151_ChIP-Seq_293T_Human0.84367370
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84330592
159BCAT_22108803_ChIP-Seq_LS180_Human0.83777933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.13172643
2MP0003705_abnormal_hypodermis_morpholog3.77836751
3MP0003566_abnormal_cell_adhesion3.64563534
4MP0006054_spinal_hemorrhage3.46932050
5MP0003690_abnormal_glial_cell3.43636313
6MP0002877_abnormal_melanocyte_morpholog3.26005973
7MP0003880_abnormal_central_pattern2.78967639
8MP0001984_abnormal_olfaction2.77071267
9MP0003279_aneurysm2.52775160
10MP0005171_absent_coat_pigmentation2.52621227
11MP0000013_abnormal_adipose_tissue2.48003497
12MP0005257_abnormal_intraocular_pressure2.36090573
13MP0003329_amyloid_beta_deposits2.34107547
14MP0005275_abnormal_skin_tensile2.33074900
15MP0005023_abnormal_wound_healing2.32808109
16MP0010352_gastrointestinal_tract_polyps2.29496521
17MP0003950_abnormal_plasma_membrane2.29005422
18MP0003136_yellow_coat_color2.13948292
19MP0003634_abnormal_glial_cell2.13381581
20MP0004742_abnormal_vestibular_system2.09370919
21MP0001968_abnormal_touch/_nociception2.08978271
22MP0008438_abnormal_cutaneous_collagen2.05659155
23MP0001958_emphysema2.00060034
24MP0005167_abnormal_blood-brain_barrier1.98327643
25MP0004885_abnormal_endolymph1.97687523
26MP0005423_abnormal_somatic_nervous1.90203082
27MP0004270_analgesia1.87504162
28MP0004272_abnormal_basement_membrane1.82963385
29MP0005409_darkened_coat_color1.82563361
30MP0002736_abnormal_nociception_after1.82458557
31MP0001486_abnormal_startle_reflex1.82154227
32MP0000778_abnormal_nervous_system1.78930457
33MP0000604_amyloidosis1.77941945
34MP0002272_abnormal_nervous_system1.77490014
35MP0005503_abnormal_tendon_morphology1.73565036
36MP0001915_intracranial_hemorrhage1.69171741
37MP0003191_abnormal_cellular_cholesterol1.68336068
38MP0002064_seizures1.68324657
39MP0002896_abnormal_bone_mineralization1.65811501
40MP0001879_abnormal_lymphatic_vessel1.65379207
41MP0004858_abnormal_nervous_system1.62171093
42MP0003300_gastrointestinal_ulcer1.60912974
43MP0005623_abnormal_meninges_morphology1.60261664
44MP0001299_abnormal_eye_distance/1.59954495
45MP0000569_abnormal_digit_pigmentation1.56014271
46MP0003172_abnormal_lysosome_physiology1.55425463
47MP0003724_increased_susceptibility_to1.52832675
48MP0004859_abnormal_synaptic_plasticity1.51368306
49MP0002060_abnormal_skin_morphology1.51017523
50MP0003635_abnormal_synaptic_transmissio1.50160473
51MP0002735_abnormal_chemical_nociception1.49564108
52MP0004134_abnormal_chest_morphology1.47933946
53MP0009780_abnormal_chondrocyte_physiolo1.44729658
54MP0000003_abnormal_adipose_tissue1.41884886
55MP0001485_abnormal_pinna_reflex1.41848460
56MP0002734_abnormal_mechanical_nocicepti1.40232075
57MP0002090_abnormal_vision1.38682131
58MP0005360_urolithiasis1.38091194
59MP0009697_abnormal_copulation1.37645873
60MP0002733_abnormal_thermal_nociception1.36513937
61MP0000762_abnormal_tongue_morphology1.34468080
62MP0004084_abnormal_cardiac_muscle1.33372415
63MP0009745_abnormal_behavioral_response1.29302807
64MP0003633_abnormal_nervous_system1.28759484
65MP0003632_abnormal_nervous_system1.28752774
66MP0002295_abnormal_pulmonary_circulatio1.27501303
67MP0001661_extended_life_span1.27364194
68MP0003075_altered_response_to1.26921875
69MP0003303_peritoneal_inflammation1.26573109
70MP0001970_abnormal_pain_threshold1.24553871
71MP0010386_abnormal_urinary_bladder1.22680518
72MP0004185_abnormal_adipocyte_glucose1.22112364
73MP0003828_pulmonary_edema1.19929920
74MP0003631_nervous_system_phenotype1.19181253
75MP0005058_abnormal_lysosome_morphology1.19136543
76MP0005164_abnormal_response_to1.18273288
77MP0001905_abnormal_dopamine_level1.17883882
78MP0001348_abnormal_lacrimal_gland1.16760469
79MP0009046_muscle_twitch1.16228877
80MP0005197_abnormal_uvea_morphology1.14284781
81MP0005388_respiratory_system_phenotype1.12884252
82MP0002133_abnormal_respiratory_system1.12884252
83MP0005464_abnormal_platelet_physiology1.12832135
84MP0002067_abnormal_sensory_capabilities1.11674140
85MP0000751_myopathy1.10519344
86MP0005076_abnormal_cell_differentiation1.10163966
87MP0002063_abnormal_learning/memory/cond1.09961095
88MP0002572_abnormal_emotion/affect_behav1.07748759
89MP0005508_abnormal_skeleton_morphology1.07377223
90MP0010368_abnormal_lymphatic_system1.07314502
91MP0004130_abnormal_muscle_cell1.07296725
92MP0001177_atelectasis1.06724469
93MP0009384_cardiac_valve_regurgitation1.05428853
94MP0005595_abnormal_vascular_smooth1.04694258
95MP0001243_abnormal_dermal_layer1.04494994
96MP0008875_abnormal_xenobiotic_pharmacok1.04344292
97MP0003091_abnormal_cell_migration1.04012912
98MP0003868_abnormal_feces_composition1.03667246
99MP0001440_abnormal_grooming_behavior1.03467501
100MP0003385_abnormal_body_wall1.02880485
101MP0002229_neurodegeneration1.02875274
102MP0002128_abnormal_blood_circulation1.02652092
103MP0003656_abnormal_erythrocyte_physiolo1.01594576
104MP0009053_abnormal_anal_canal1.00559354
105MP0000733_abnormal_muscle_development0.99531349
106MP0002882_abnormal_neuron_morphology0.98676902
107MP0001614_abnormal_blood_vessel0.98106386
108MP0004782_abnormal_surfactant_physiolog0.97078476
109MP0000749_muscle_degeneration0.94344982
110MP0005621_abnormal_cell_physiology0.93132450
111MP0004142_abnormal_muscle_tone0.92913124
112MP0003183_abnormal_peptide_metabolism0.90845881
113MP0005408_hypopigmentation0.89890939
114MP0001851_eye_inflammation0.89884267
115MP0003448_altered_tumor_morphology0.89529414
116MP0000534_abnormal_ureter_morphology0.89407488
117MP0005195_abnormal_posterior_eye0.87353988
118MP0002332_abnormal_exercise_endurance0.87298319
119MP0001963_abnormal_hearing_physiology0.85743198
120MP0000858_altered_metastatic_potential0.85019345
121MP0003941_abnormal_skin_development0.85010712
122MP0000465_gastrointestinal_hemorrhage0.84838196
123MP0003935_abnormal_craniofacial_develop0.82944748
124MP0005551_abnormal_eye_electrophysiolog0.82583260
125MP0000428_abnormal_craniofacial_morphol0.82085754
126MP0005193_abnormal_anterior_eye0.82045668
127MP0004233_abnormal_muscle_weight0.81943433
128MP0002925_abnormal_cardiovascular_devel0.81845210
129MP0010678_abnormal_skin_adnexa0.80354067
130MP0000955_abnormal_spinal_cord0.80023812
131MP0008004_abnormal_stomach_pH0.79943057
132MP0006082_CNS_inflammation0.79393394
133MP0002184_abnormal_innervation0.79253878
134MP0000249_abnormal_blood_vessel0.79207183
135MP0002419_abnormal_innate_immunity0.77954878
136MP0005248_abnormal_Harderian_gland0.77799253
137MP0008874_decreased_physiological_sensi0.77451099
138MP0001986_abnormal_taste_sensitivity0.77137913
139MP0001849_ear_inflammation0.76889461
140MP0002066_abnormal_motor_capabilities/c0.75768084
141MP0000343_altered_response_to0.75527691
142MP0003453_abnormal_keratinocyte_physiol0.74641081
143MP0002752_abnormal_somatic_nervous0.74491545
144MP0003755_abnormal_palate_morphology0.73931621
145MP0006138_congestive_heart_failure0.73747825
146MP0001529_abnormal_vocalization0.72730126
147MP0004036_abnormal_muscle_relaxation0.72483139
148MP0002118_abnormal_lipid_homeostasis0.71909333
149MP0005584_abnormal_enzyme/coenzyme_acti0.71642993
150MP0005410_abnormal_fertilization0.71445186
151MP0002177_abnormal_outer_ear0.70760203
152MP0004883_abnormal_blood_vessel0.69832407
153MP0000767_abnormal_smooth_muscle0.68673330
154MP0005375_adipose_tissue_phenotype0.68484172
155MP0001542_abnormal_bone_strength0.67908047
156MP0002138_abnormal_hepatobiliary_system0.67445754
157MP0002166_altered_tumor_susceptibility0.67081782
158MP0005165_increased_susceptibility_to0.67000758
159MP0004808_abnormal_hematopoietic_stem0.66815464
160MP0000163_abnormal_cartilage_morphology0.66675563
161MP0002998_abnormal_bone_remodeling0.64063006
162MP0002697_abnormal_eye_size0.63881356
163MP0003252_abnormal_bile_duct0.61762433
164MP0001175_abnormal_lung_morphology0.59968443
165MP0010030_abnormal_orbit_morphology0.58365792
166MP0005390_skeleton_phenotype0.58101632
167MP0002086_abnormal_extraembryonic_tissu0.57958421
168MP0002092_abnormal_eye_morphology0.57356933
169MP0005384_cellular_phenotype0.57072690
170MP0002115_abnormal_skeleton_extremities0.56626972
171MP0002089_abnormal_postnatal_growth/wei0.56601267
172MP0002233_abnormal_nose_morphology0.56472794

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.13586012
2Premature rupture of membranes (HP:0001788)5.92870746
3Neurofibrillary tangles (HP:0002185)5.63735769
4Aortic dissection (HP:0002647)5.14065994
5Arterial tortuosity (HP:0005116)5.07863909
6Vascular tortuosity (HP:0004948)4.87407190
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.66363763
8Degeneration of the lateral corticospinal tracts (HP:0002314)4.66363763
9Aortic aneurysm (HP:0004942)4.65375197
10Cerebral inclusion bodies (HP:0100314)4.21068034
11Sensory axonal neuropathy (HP:0003390)4.01337381
12Cerebral hemorrhage (HP:0001342)3.79465038
13Ankle contracture (HP:0006466)3.79232871
14Abnormality of the corticospinal tract (HP:0002492)3.77687416
15Peripheral hypomyelination (HP:0007182)3.77220242
16Atrophic scars (HP:0001075)3.75744577
17Termporal pattern (HP:0011008)3.75228650
18Insidious onset (HP:0003587)3.75228650
19Supranuclear gaze palsy (HP:0000605)3.73639716
20Mitral stenosis (HP:0001718)3.65771549
21Follicular hyperkeratosis (HP:0007502)3.57948856
22Vertebral compression fractures (HP:0002953)3.51099136
23Parakeratosis (HP:0001036)3.33671530
24Spondylolisthesis (HP:0003302)3.31884703
25Spinal rigidity (HP:0003306)3.27443073
26Soft skin (HP:0000977)3.17570598
27Bladder diverticulum (HP:0000015)3.17175981
28Wormian bones (HP:0002645)3.08492072
29Cervical subluxation (HP:0003308)3.05940524
30Retinal dysplasia (HP:0007973)2.93758429
31Mitral valve prolapse (HP:0001634)2.93194727
32Onion bulb formation (HP:0003383)2.88079078
33Abnormality of dentin (HP:0010299)2.87643710
34Intention tremor (HP:0002080)2.87386794
35Fragile skin (HP:0001030)2.81144864
36Increased mean platelet volume (HP:0011877)2.80334005
37Amyloidosis (HP:0011034)2.79654169
38Spinal cord lesions (HP:0100561)2.75138516
39Syringomyelia (HP:0003396)2.75138516
40Deep venous thrombosis (HP:0002625)2.68625638
41Abnormal auditory evoked potentials (HP:0006958)2.61860937
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.59166628
43Vertebral arch anomaly (HP:0008438)2.58454163
44Increased cerebral lipofuscin (HP:0011813)2.54422274
45Spontaneous hematomas (HP:0007420)2.53205708
46Action tremor (HP:0002345)2.52776997
47Abolished electroretinogram (ERG) (HP:0000550)2.52146702
48Wide anterior fontanel (HP:0000260)2.50015720
49Neonatal short-limb short stature (HP:0008921)2.48613730
50Cardiovascular calcification (HP:0011915)2.45660535
51Menorrhagia (HP:0000132)2.45358879
52Cerebral aneurysm (HP:0004944)2.43480742
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.43021481
54Osteolytic defects of the hand bones (HP:0009699)2.43021481
55Akinesia (HP:0002304)2.42875452
56Peritonitis (HP:0002586)2.39556186
57Myokymia (HP:0002411)2.38137593
58Dysmetria (HP:0001310)2.36717928
59Spastic gait (HP:0002064)2.36427302
60J-shaped sella turcica (HP:0002680)2.36131963
61Overgrowth (HP:0001548)2.35110960
62Visceral angiomatosis (HP:0100761)2.33979677
63Blue sclerae (HP:0000592)2.32829363
64Short nail (HP:0001799)2.30973108
65Aneurysm (HP:0002617)2.29827985
66Abnormal platelet volume (HP:0011876)2.29301575
67Clumsiness (HP:0002312)2.29236741
68Hydroureter (HP:0000072)2.28560646
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27950752
70Dilatation of the ascending aorta (HP:0005111)2.27109438
71Long toe (HP:0010511)2.24404700
72Abnormality of the parathyroid morphology (HP:0011766)2.22317938
73Hyperextensible skin (HP:0000974)2.19980544
74Aortic regurgitation (HP:0001659)2.19962319
75Slow saccadic eye movements (HP:0000514)2.19486473
76Absent frontal sinuses (HP:0002688)2.19346760
77Conjugated hyperbilirubinemia (HP:0002908)2.19147683
78Abnormality of the acetabulum (HP:0003170)2.18357460
79Ankle clonus (HP:0011448)2.18015953
80Mitral regurgitation (HP:0001653)2.17273784
81White forelock (HP:0002211)2.16471577
82Megalencephaly (HP:0001355)2.15806557
83Protruding ear (HP:0000411)2.15797602
84Hypoplasia of the iris (HP:0007676)2.14887122
85Pulmonic stenosis (HP:0001642)2.14579401
86Striae distensae (HP:0001065)2.14338390
87Thoracolumbar scoliosis (HP:0002944)2.13011241
88Tetraparesis (HP:0002273)2.12516546
89Hemangiomatosis (HP:0007461)2.11171348
90Lower limb muscle weakness (HP:0007340)2.11029514
91Segmental peripheral demyelination/remyelination (HP:0003481)2.09900829
92Scanning speech (HP:0002168)2.09768173
93Elbow flexion contracture (HP:0002987)2.08705330
94Hemorrhage of the eye (HP:0011885)2.08327815
95Joint laxity (HP:0001388)2.07182973
96Hematochezia (HP:0002573)2.07027698
97Genu recurvatum (HP:0002816)2.05696195
98Pulmonary embolism (HP:0002204)2.04638907
99Premature skin wrinkling (HP:0100678)2.04391997
100Synostosis involving the elbow (HP:0003938)2.03948340
101Humeroradial synostosis (HP:0003041)2.03948340
102Loss of speech (HP:0002371)2.03812914
103Patchy hypopigmentation of hair (HP:0011365)2.00336476
104Abnormality of the intrinsic pathway (HP:0010989)2.00099696
105Buphthalmos (HP:0000557)1.99149270
106Abnormal delivery (HP:0001787)1.97585793
107Spastic paraparesis (HP:0002313)1.96735253
108Vascular calcification (HP:0004934)1.96405469
109Hypoplastic pelvis (HP:0008839)1.96161578
110Shallow orbits (HP:0000586)1.95926970
111Broad ribs (HP:0000885)1.95645174
112Interstitial pulmonary disease (HP:0006530)1.95360374
113Peripheral demyelination (HP:0011096)1.94122821
114Hepatosplenomegaly (HP:0001433)1.94121122
115Atonic seizures (HP:0010819)1.93272340
116Nonimmune hydrops fetalis (HP:0001790)1.93256615
117Diplopia (HP:0000651)1.93195708
118Abnormality of binocular vision (HP:0011514)1.93195708
119Bowel diverticulosis (HP:0005222)1.93151308
120Abnormality of oral frenula (HP:0000190)1.92872561
121Epiphyseal dysplasia (HP:0002656)1.92228989
122Myocardial infarction (HP:0001658)1.91938488
123Ankyloglossia (HP:0010296)1.90784905
124Broad face (HP:0000283)1.89985421
125Slender build (HP:0001533)1.89753631
126Abnormality of the common coagulation pathway (HP:0010990)1.89592875
127Ulnar bowing (HP:0003031)1.87999763
128Decreased skull ossification (HP:0004331)1.87694469
129Glucose intolerance (HP:0000833)1.85979434
130Aortic valve stenosis (HP:0001650)1.84922983
131Back pain (HP:0003418)1.84811980
132Broad metatarsal (HP:0001783)1.84559387
133Abnormality of the Achilles tendon (HP:0005109)1.84449212
134Abnormality of skull ossification (HP:0002703)1.84419738
135Dysostosis multiplex (HP:0000943)1.82639842
136Thick nail (HP:0001805)1.82538690
137Hammertoe (HP:0001765)1.82361088
138Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81551038
139Hypomagnesemia (HP:0002917)1.81206838
140Stridor (HP:0010307)1.79146992
141Pulmonary artery stenosis (HP:0004415)1.78870345
142Tibial bowing (HP:0002982)1.78642081
143Renal duplication (HP:0000075)1.78621585
144Coxa vara (HP:0002812)1.78314463
145Polycythemia (HP:0001901)1.78251718
146Ulnar claw (HP:0001178)1.77823459
147Hypoplastic left heart (HP:0004383)1.77763471
148Type 1 muscle fiber predominance (HP:0003803)1.77681914
149Achilles tendon contracture (HP:0001771)1.77632706
150Hyperlipoproteinemia (HP:0010980)1.77162734
151Abnormality of the lumbar spine (HP:0100712)1.77072495
152Delayed closure of the anterior fontanelle (HP:0001476)1.77036472
153Coronal craniosynostosis (HP:0004440)1.76962673
154Knee flexion contracture (HP:0006380)1.76959395
155Infantile muscular hypotonia (HP:0008947)1.76861986
156Aplasia of the phalanges of the hand (HP:0009802)1.76416771
157Aplasia involving bones of the extremities (HP:0009825)1.76416771
158Aplasia involving bones of the upper limbs (HP:0009823)1.76416771
159Biconcave vertebral bodies (HP:0004586)1.76191021
160Hyperacusis (HP:0010780)1.76046861
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75741594
162Autoamputation (HP:0001218)1.72945577
163Neuroendocrine neoplasm (HP:0100634)1.72503679
164Gastrointestinal stroma tumor (HP:0100723)1.71919315
165Asymmetry of the thorax (HP:0001555)1.71600597
166Osteoarthritis (HP:0002758)1.70695250
167Abnormality of the pulmonary veins (HP:0011718)1.70247195
168Axonal loss (HP:0003447)1.69410430
169Pectus carinatum (HP:0000768)1.68738364
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67929349
171Disproportionate tall stature (HP:0001519)1.67475290
172Hypokalemic alkalosis (HP:0001949)1.67235890
173Increased circulating renin level (HP:0000848)1.66756334
174Blue irides (HP:0000635)1.66065604
175Wrist flexion contracture (HP:0001239)1.65202545
176Hyperventilation (HP:0002883)1.65080238
177Purpura (HP:0000979)1.64946420
178Pheochromocytoma (HP:0002666)1.64689543
179Papillary thyroid carcinoma (HP:0002895)1.64144831
180Increased variability in muscle fiber diameter (HP:0003557)1.63842388
181Abnormality of glycolipid metabolism (HP:0010969)1.62958004
182Abnormality of liposaccharide metabolism (HP:0010968)1.62958004
183Abnormality of glycosphingolipid metabolism (HP:0004343)1.62958004
184Flat acetabular roof (HP:0003180)1.62656709
185Progressive cerebellar ataxia (HP:0002073)1.62586054
186Paraparesis (HP:0002385)1.62161660
187Limb-girdle muscle weakness (HP:0003325)1.62059598
188Steppage gait (HP:0003376)1.61901164
189Neuronal loss in central nervous system (HP:0002529)1.59766272
190Progressive inability to walk (HP:0002505)1.59453898
191Focal seizures (HP:0007359)1.58587553
192Chronic otitis media (HP:0000389)1.57303169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.48015384
2STK393.78128899
3MYLK3.46310168
4FES3.31670449
5TNIK3.26281677
6CASK3.05630866
7FLT32.91335134
8MST1R2.75843068
9TYRO32.71810623
10MAP3K122.49093042
11TIE12.37498338
12ERBB42.35694359
13OXSR12.29453548
14LATS12.25855807
15IRAK32.18610169
16NEK92.18513195
17TTN2.07580649
18SCYL22.06193655
19PKN11.97162790
20FGR1.87213872
21LATS21.85666972
22PKN21.83991718
23CDK81.78155702
24NTRK11.72115723
25FGFR21.68602646
26EPHA21.61208364
27PAK41.60678215
28TESK11.53839900
29PHKG11.48044337
30PHKG21.48044337
31PAK21.47902924
32TRIM281.47036566
33EPHA41.46255232
34BRSK21.46234345
35KSR11.46116204
36IRAK21.46109641
37PNCK1.43699720
38CSK1.41443495
39CAMK1G1.37377485
40ICK1.32595374
41PDGFRB1.32352973
42STK38L1.30638196
43PIK3CG1.29228317
44IRAK11.29104021
45BCR1.23504419
46ROCK21.23320894
47CAMKK21.22375583
48MET1.22304493
49MARK11.21740377
50STK31.19060379
51PTK2B1.18830799
52IRAK41.18730916
53PRKCQ1.17813707
54MOS1.17718063
55MAP3K91.17117549
56UHMK11.15593198
57MAPKAPK51.15346915
58MAPK131.11692207
59LIMK11.11421313
60RIPK41.06948575
61ERBB31.05074121
62RET1.03088210
63STK381.02141422
64CSNK1A1L1.01402769
65CAMK1D1.00588291
66WNK40.99390122
67NTRK20.99045742
68AKT30.98949145
69LMTK20.98231633
70MELK0.95640552
71CSNK1G30.94417339
72FYN0.94361824
73EIF2AK30.92337400
74CSF1R0.91550951
75SGK2230.88790309
76SGK4940.88790309
77PAK30.87411248
78SIK10.87400510
79CDK50.86349450
80PRPF4B0.84864984
81CSNK1G20.84757577
82RIPK10.83892116
83CSNK1G10.83171070
84PRKCE0.82891767
85PRKG20.79035027
86CAMK2D0.74303961
87EPHA30.73861017
88PDPK10.73566489
89WNK10.72261298
90CAMK2B0.70972494
91MARK20.70930094
92KIT0.70511303
93PAK60.69327066
94BMX0.68829070
95ROCK10.68483540
96MST40.67500103
97ERN10.65675733
98GSK3A0.65518792
99MINK10.65502190
100TGFBR20.64337119
101CAMK2A0.64210725
102INSR0.64164169
103ILK0.62997212
104GRK70.62432184
105PRKD10.60874626
106ABL20.60538567
107SRC0.58907597
108JAK10.58314188
109MAPK150.58260887
110CDK90.57716430
111PTK60.57012491
112CLK10.56837559
113CCNB10.56148913
114TRIB30.55952371
115NEK60.54026245
116DAPK20.53911424
117NUAK10.53410011
118TRPM70.52352387
119TAF10.51784506
120DMPK0.51613749
121PDGFRA0.50835707
122YES10.49836335
123PRKCH0.48717410
124MAP3K130.47177871
125PRKAA20.47115544
126ADRBK10.46906550
127EIF2AK10.46784781
128LRRK20.46351183
129LCK0.45951917
130KSR20.45701522
131BMPR20.45689839
132EPHB20.45385460
133EGFR0.44306199
134TBK10.44295471
135PLK20.43816503
136CAMK2G0.42908282
137MTOR0.42586563
138ABL10.42438815
139HCK0.42312374
140PBK0.41558990
141DDR20.41534616
142GRK10.41247486
143SGK30.41081731
144PTK20.41057815
145LYN0.40747037
146MAP3K20.40702356
147PRKG10.40496049
148GRK50.39412689
149PDK10.39368064
150TGFBR10.38924197
151IGF1R0.34120275
152MAP3K140.30872499
153BRSK10.28794917
154DYRK1B0.28036335
155MAP2K10.26405817
156MAP2K70.26375047
157EIF2AK20.26033779
158ARAF0.25189558
159CDK180.25089092

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.61618472
2Steroid biosynthesis_Homo sapiens_hsa001002.99884573
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74271119
4Fatty acid elongation_Homo sapiens_hsa000622.48786047
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28167079
6Proteoglycans in cancer_Homo sapiens_hsa052051.99658017
7Adherens junction_Homo sapiens_hsa045201.94843689
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.87802430
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.84507127
10Small cell lung cancer_Homo sapiens_hsa052221.81667646
11Ether lipid metabolism_Homo sapiens_hsa005651.75577840
12Olfactory transduction_Homo sapiens_hsa047401.75524843
13Axon guidance_Homo sapiens_hsa043601.70544806
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.67651592
15Nitrogen metabolism_Homo sapiens_hsa009101.67548607
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.66608754
17Chronic myeloid leukemia_Homo sapiens_hsa052201.56765874
18Fatty acid biosynthesis_Homo sapiens_hsa000611.55460449
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49062130
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44492964
21Dilated cardiomyopathy_Homo sapiens_hsa054141.43690062
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.43036185
23Glutamatergic synapse_Homo sapiens_hsa047241.40162060
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38693686
25Fatty acid metabolism_Homo sapiens_hsa012121.36351352
26Pancreatic cancer_Homo sapiens_hsa052121.34940627
27Hippo signaling pathway_Homo sapiens_hsa043901.32821758
28Sphingolipid metabolism_Homo sapiens_hsa006001.32650230
29Melanoma_Homo sapiens_hsa052181.21933992
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19265363
31Butanoate metabolism_Homo sapiens_hsa006501.18838713
32Bladder cancer_Homo sapiens_hsa052191.16816212
33GABAergic synapse_Homo sapiens_hsa047271.14222803
34Sphingolipid signaling pathway_Homo sapiens_hsa040711.12474442
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.11102220
36MicroRNAs in cancer_Homo sapiens_hsa052061.10451345
37Morphine addiction_Homo sapiens_hsa050321.09799398
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.09395359
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09053515
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08245619
41TGF-beta signaling pathway_Homo sapiens_hsa043501.06240708
42Pathways in cancer_Homo sapiens_hsa052001.03564454
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03367070
44ECM-receptor interaction_Homo sapiens_hsa045121.03305577
45ErbB signaling pathway_Homo sapiens_hsa040121.02789885
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02388823
47Cholinergic synapse_Homo sapiens_hsa047251.02357842
48N-Glycan biosynthesis_Homo sapiens_hsa005101.01379355
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.00135382
50PPAR signaling pathway_Homo sapiens_hsa033200.99846586
51Endometrial cancer_Homo sapiens_hsa052130.97005050
52Renal cell carcinoma_Homo sapiens_hsa052110.96473300
53Propanoate metabolism_Homo sapiens_hsa006400.96345084
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96009946
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94377289
56Salivary secretion_Homo sapiens_hsa049700.94189812
57Renin secretion_Homo sapiens_hsa049240.93962835
58Sulfur metabolism_Homo sapiens_hsa009200.93565814
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.93196532
60Serotonergic synapse_Homo sapiens_hsa047260.91526067
61Thyroid cancer_Homo sapiens_hsa052160.89840260
62Histidine metabolism_Homo sapiens_hsa003400.88164756
63Platelet activation_Homo sapiens_hsa046110.87607282
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86879331
65Protein digestion and absorption_Homo sapiens_hsa049740.86835583
66Complement and coagulation cascades_Homo sapiens_hsa046100.85767839
67Long-term depression_Homo sapiens_hsa047300.85614976
68Hedgehog signaling pathway_Homo sapiens_hsa043400.85227956
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85000352
70Focal adhesion_Homo sapiens_hsa045100.84694780
71Peroxisome_Homo sapiens_hsa041460.84210218
72Circadian rhythm_Homo sapiens_hsa047100.80979868
73Circadian entrainment_Homo sapiens_hsa047130.80685886
74Lysosome_Homo sapiens_hsa041420.80399910
75Gastric acid secretion_Homo sapiens_hsa049710.80095734
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79782776
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78792542
78Vitamin B6 metabolism_Homo sapiens_hsa007500.77752936
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77186707
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76878918
81Prolactin signaling pathway_Homo sapiens_hsa049170.76220962
82Malaria_Homo sapiens_hsa051440.75802044
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.75565560
84Phagosome_Homo sapiens_hsa041450.75512012
85Ovarian steroidogenesis_Homo sapiens_hsa049130.74811628
86Fatty acid degradation_Homo sapiens_hsa000710.74498577
87Staphylococcus aureus infection_Homo sapiens_hsa051500.74351989
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73078351
89Prion diseases_Homo sapiens_hsa050200.72843858
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72696046
91Non-small cell lung cancer_Homo sapiens_hsa052230.72381079
92Bile secretion_Homo sapiens_hsa049760.71360992
93Viral myocarditis_Homo sapiens_hsa054160.71127247
94Prostate cancer_Homo sapiens_hsa052150.71125614
95Dopaminergic synapse_Homo sapiens_hsa047280.71120227
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70644315
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69805346
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69455052
99Endocytosis_Homo sapiens_hsa041440.69356881
100Choline metabolism in cancer_Homo sapiens_hsa052310.69098545
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.65380698
102Ras signaling pathway_Homo sapiens_hsa040140.64084636
103Amoebiasis_Homo sapiens_hsa051460.62624613
104Dorso-ventral axis formation_Homo sapiens_hsa043200.62439689
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61544324
106TNF signaling pathway_Homo sapiens_hsa046680.61534648
107Melanogenesis_Homo sapiens_hsa049160.60471169
108Salmonella infection_Homo sapiens_hsa051320.60341930
109FoxO signaling pathway_Homo sapiens_hsa040680.60058408
110Other glycan degradation_Homo sapiens_hsa005110.59267945
111Gap junction_Homo sapiens_hsa045400.59258185
112Chemokine signaling pathway_Homo sapiens_hsa040620.57673243
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.56864847
114Rap1 signaling pathway_Homo sapiens_hsa040150.56566314
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56519913
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56489896
117Wnt signaling pathway_Homo sapiens_hsa043100.56274596
118Hepatitis B_Homo sapiens_hsa051610.55490480
119Long-term potentiation_Homo sapiens_hsa047200.54933940
120cAMP signaling pathway_Homo sapiens_hsa040240.54183558
121Glioma_Homo sapiens_hsa052140.53917321
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.53200238
123Rheumatoid arthritis_Homo sapiens_hsa053230.53113841
124Caffeine metabolism_Homo sapiens_hsa002320.52579831
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51051353
126Pertussis_Homo sapiens_hsa051330.50481116
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49586799
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48874097
129mTOR signaling pathway_Homo sapiens_hsa041500.47553628
130Inositol phosphate metabolism_Homo sapiens_hsa005620.47310883
131Colorectal cancer_Homo sapiens_hsa052100.47140056
132Oxytocin signaling pathway_Homo sapiens_hsa049210.46407683
133MAPK signaling pathway_Homo sapiens_hsa040100.46032486
134VEGF signaling pathway_Homo sapiens_hsa043700.45845840
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45831475
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45430710
137Tight junction_Homo sapiens_hsa045300.44875200
138Vibrio cholerae infection_Homo sapiens_hsa051100.44661043
139Insulin signaling pathway_Homo sapiens_hsa049100.44216740
140Osteoclast differentiation_Homo sapiens_hsa043800.43900021
141Shigellosis_Homo sapiens_hsa051310.43753946
142GnRH signaling pathway_Homo sapiens_hsa049120.43451470
143Thyroid hormone synthesis_Homo sapiens_hsa049180.43437793
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43397609
145AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41964746
146Estrogen signaling pathway_Homo sapiens_hsa049150.41523315
147Glycerolipid metabolism_Homo sapiens_hsa005610.41511607
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41272125
149B cell receptor signaling pathway_Homo sapiens_hsa046620.40628259
150African trypanosomiasis_Homo sapiens_hsa051430.40435624
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39810203
152AMPK signaling pathway_Homo sapiens_hsa041520.38997850
153Basal cell carcinoma_Homo sapiens_hsa052170.37696737
154Toxoplasmosis_Homo sapiens_hsa051450.37041096

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