KLHL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.50196713
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.68798285
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.68798285
4antigen processing and presentation of endogenous antigen (GO:0019883)5.61168683
5ribosomal small subunit assembly (GO:0000028)5.25945098
6regulation of B cell receptor signaling pathway (GO:0050855)5.25069278
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.06600580
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.03741709
9regulation of gamma-delta T cell differentiation (GO:0045586)4.96383641
10regulation of gamma-delta T cell activation (GO:0046643)4.59896424
11* B cell receptor signaling pathway (GO:0050853)4.58017333
12positive regulation of B cell differentiation (GO:0045579)4.51399760
13mast cell activation (GO:0045576)4.21226923
14regulation of B cell differentiation (GO:0045577)4.19749604
15tolerance induction (GO:0002507)4.05977521
16cilium or flagellum-dependent cell motility (GO:0001539)3.96019355
17negative T cell selection (GO:0043383)3.90456598
18negative regulation of phagocytosis (GO:0050765)3.88661892
19negative thymic T cell selection (GO:0045060)3.83476998
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.79074700
21positive thymic T cell selection (GO:0045059)3.72811836
22leukocyte aggregation (GO:0070486)3.71174411
23antigen processing and presentation via MHC class Ib (GO:0002475)3.61988597
24T cell homeostasis (GO:0043029)3.58317968
25regulation of germinal center formation (GO:0002634)3.56948124
26regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.55979042
27viral transcription (GO:0019083)3.55437295
28macrophage activation involved in immune response (GO:0002281)3.53375804
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.52644451
30axonemal dynein complex assembly (GO:0070286)3.52524759
31definitive hemopoiesis (GO:0060216)3.52425620
32T cell migration (GO:0072678)3.52234145
33response to interleukin-15 (GO:0070672)3.51750838
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48671344
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44369238
36negative regulation of cell killing (GO:0031342)3.44369238
37negative regulation of T cell mediated immunity (GO:0002710)3.43705636
38defense response to protozoan (GO:0042832)3.42887601
39cellular response to interleukin-15 (GO:0071350)3.37060891
40translational termination (GO:0006415)3.36575853
41negative regulation of interleukin-12 production (GO:0032695)3.35988422
42mast cell activation involved in immune response (GO:0002279)3.31859531
43mast cell degranulation (GO:0043303)3.31859531
44positive regulation by symbiont of host defense response (GO:0052509)3.29485305
45modulation by symbiont of host defense response (GO:0052031)3.29485305
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29485305
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29485305
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.29485305
49modulation by symbiont of host immune response (GO:0052553)3.29485305
50response to protozoan (GO:0001562)3.27495006
51cellular extravasation (GO:0045123)3.26150285
52cellular response to zinc ion (GO:0071294)3.25867021
53megakaryocyte development (GO:0035855)3.25098172
54positive regulation of mast cell activation (GO:0033005)3.24266632
55* antigen receptor-mediated signaling pathway (GO:0050851)3.21470511
56lymphocyte homeostasis (GO:0002260)3.18206203
57negative regulation of leukocyte mediated immunity (GO:0002704)3.17825549
58telomere maintenance via semi-conservative replication (GO:0032201)3.16752469
59regulation of tolerance induction (GO:0002643)3.16624720
60neutrophil activation (GO:0042119)3.13952949
61negative regulation of T-helper cell differentiation (GO:0045623)3.13546552
62negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13546552
63immunoglobulin mediated immune response (GO:0016064)3.12824050
64myeloid cell activation involved in immune response (GO:0002275)3.12421635
65regulation of T-helper 1 cell differentiation (GO:0045625)3.11002534
66positive regulation of granulocyte differentiation (GO:0030854)3.10276877
67interferon-gamma production (GO:0032609)3.10213950
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09287206
69positive regulation of tolerance induction (GO:0002645)3.08515400
70regulation of antigen processing and presentation (GO:0002577)3.08269707
71negative regulation of adaptive immune response (GO:0002820)3.08197638
72mature B cell differentiation involved in immune response (GO:0002313)3.07386087
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05233272
74positive T cell selection (GO:0043368)3.04776848
75detection of other organism (GO:0098543)3.03978793
76DNA strand elongation involved in DNA replication (GO:0006271)3.03491066
77T cell selection (GO:0045058)3.01404780
78regulation of T cell receptor signaling pathway (GO:0050856)3.00941450
79thymic T cell selection (GO:0045061)3.00109801
80myeloid dendritic cell activation (GO:0001773)2.99775016
81mature B cell differentiation (GO:0002335)2.99647378
82regulation of mast cell activation (GO:0033003)2.98821213
83translational elongation (GO:0006414)2.98106910
84positive regulation of B cell activation (GO:0050871)2.97881940
85response to peptidoglycan (GO:0032494)2.97881556
86Peyers patch development (GO:0048541)2.97523475
87mucosal-associated lymphoid tissue development (GO:0048537)2.97523475
88regulation of interleukin-12 biosynthetic process (GO:0045075)2.96737983
89detection of bacterium (GO:0016045)2.96157821
90DNA strand elongation (GO:0022616)2.95288196
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93734678
92leukocyte homeostasis (GO:0001776)2.92408842
93granulocyte activation (GO:0036230)2.92184671
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91219358
95positive regulation of mast cell degranulation (GO:0043306)2.91199529
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.91199529
97response to type I interferon (GO:0034340)2.90990812
98regulation of mast cell degranulation (GO:0043304)2.89609949
99positive regulation of B cell proliferation (GO:0030890)2.89126403
100ribosomal small subunit biogenesis (GO:0042274)2.88925253
101positive regulation of antigen processing and presentation (GO:0002579)2.87790966
102type I interferon signaling pathway (GO:0060337)2.87112202
103cellular response to type I interferon (GO:0071357)2.87112202
104lymph node development (GO:0048535)2.86584972
105regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.86466797
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84277347
107somatic hypermutation of immunoglobulin genes (GO:0016446)2.84277347
108cotranslational protein targeting to membrane (GO:0006613)2.83239844
109interferon-gamma-mediated signaling pathway (GO:0060333)2.82128132
110regulation of B cell proliferation (GO:0030888)2.82021091
111B cell mediated immunity (GO:0019724)2.81696397
112protein targeting to ER (GO:0045047)2.81327663
113* germinal center formation (GO:0002467)2.80079182
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79728536
115regulation of interferon-beta biosynthetic process (GO:0045357)2.79402386
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79244870
117regulation of alpha-beta T cell activation (GO:0046634)2.79011863
118telomere maintenance via recombination (GO:0000722)2.78112249
119regulation of mast cell activation involved in immune response (GO:0033006)2.77927331
120regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.77596133
121regulation of alpha-beta T cell proliferation (GO:0046640)2.76905055
122T cell receptor signaling pathway (GO:0050852)2.76377577
123positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.75980963
124cellular response to exogenous dsRNA (GO:0071360)2.75394070
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74887823
126response to muramyl dipeptide (GO:0032495)2.73719561
127positive regulation of defense response to virus by host (GO:0002230)2.72459392
128B cell homeostasis (GO:0001782)2.72006465
129cytidine metabolic process (GO:0046087)2.70394042
130cytidine catabolic process (GO:0006216)2.70394042
131cytidine deamination (GO:0009972)2.70394042
132NIK/NF-kappaB signaling (GO:0038061)2.68813846
133establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67898322
134B cell activation (GO:0042113)2.67173095
135V(D)J recombination (GO:0033151)2.64900464
136angiogenesis involved in wound healing (GO:0060055)2.64772948
137protein localization to endoplasmic reticulum (GO:0070972)2.63417752
138negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.62671628
139B cell proliferation (GO:0042100)2.60861110
140positive regulation of lamellipodium assembly (GO:0010592)2.60782328
141T cell costimulation (GO:0031295)2.59837847
142viral life cycle (GO:0019058)2.59375220
143positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59051583
144response to interferon-beta (GO:0035456)2.59014272
145regulation of response to interferon-gamma (GO:0060330)2.58975499
146regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57624588
147regulation of regulatory T cell differentiation (GO:0045589)2.57193628
148lymphocyte costimulation (GO:0031294)2.57038182
149positive regulation of isotype switching (GO:0045830)2.56265401
150mitotic recombination (GO:0006312)2.56112296
151positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55880029
152neutrophil activation involved in immune response (GO:0002283)2.55199842
153regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.55050362
154leukocyte cell-cell adhesion (GO:0007159)2.54750807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09378236
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.77372154
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.84159627
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.77948445
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.52011295
6SCL_19346495_ChIP-Seq_HPC-7_Human3.40331749
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31575612
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.22882292
9MYC_22102868_ChIP-Seq_BL_Human3.13806203
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.03047947
11* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.83221153
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58525611
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54753765
14VDR_21846776_ChIP-Seq_THP-1_Human2.46904739
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.36133889
16MYB_26560356_Chip-Seq_TH2_Human2.36009085
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34726148
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.30280629
19SPI1_23547873_ChIP-Seq_NB4_Human2.30054681
20RUNX_20019798_ChIP-Seq_JUKART_Human2.29684593
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29599486
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.27295542
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.24222600
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21143014
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15589387
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15135704
27MAF_26560356_Chip-Seq_TH1_Human2.14930293
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13238802
29* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12883529
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11945820
31MYB_26560356_Chip-Seq_TH1_Human2.10539822
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.06001565
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.03393808
34FOXM1_23109430_ChIP-Seq_U2OS_Human2.01811384
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97628363
36UTX_26944678_Chip-Seq_JUKART_Human1.96205745
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93002093
38GATA1_22025678_ChIP-Seq_K562_Human1.92850957
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91374295
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.89264216
41VDR_24787735_ChIP-Seq_THP-1_Human1.87815723
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84851285
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.83751514
44VDR_24763502_ChIP-Seq_THP-1_Human1.81346218
45CIITA_25753668_ChIP-Seq_RAJI_Human1.77719865
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76491273
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74823289
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71435011
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69653745
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.67170830
51FOXP3_21729870_ChIP-Seq_TREG_Human1.66663916
52* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65548812
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61840824
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59887603
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58497924
56VDR_23849224_ChIP-Seq_CD4+_Human1.58206714
57TCF7_22412390_ChIP-Seq_EML_Mouse1.54288757
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52240390
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51870190
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49094770
61GATA1_19941826_ChIP-Seq_K562_Human1.47013450
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46744870
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46234898
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43701880
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.42712079
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42050543
67SPI1_23127762_ChIP-Seq_K562_Human1.41035768
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38280257
69MAF_26560356_Chip-Seq_TH2_Human1.37705620
70* GABP_17652178_ChIP-ChIP_JURKAT_Human1.37678219
71GATA3_27048872_Chip-Seq_THYMUS_Human1.35565751
72SMRT_27268052_Chip-Seq_Bcells_Human1.35083977
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30875593
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26702656
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23969253
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23731585
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.21515013
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20699687
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19825214
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18396173
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15990123
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15928889
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15908052
84XRN2_22483619_ChIP-Seq_HELA_Human1.15762055
85STAT1_20625510_ChIP-Seq_HELA_Human1.14663082
86GATA2_19941826_ChIP-Seq_K562_Human1.13696719
87ELK1_19687146_ChIP-ChIP_HELA_Human1.12981616
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.12785496
89MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12621181
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12205379
91* PU_27001747_Chip-Seq_BMDM_Mouse1.10207815
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09856126
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09303126
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.08687328
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08377775
96* GATA2_21666600_ChIP-Seq_HMVEC_Human1.06269916
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.03582158
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02156422
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01181442
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00311126
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99224114
102RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98819296
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98186182
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97661359
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96337960
106NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94835404
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94827204
108GATA3_26560356_Chip-Seq_TH1_Human0.94573635
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.94516697
110* GATA3_26560356_Chip-Seq_TH2_Human0.93785931
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93449105
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92855896
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91593914
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90476868
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89745292
116KDM2B_26808549_Chip-Seq_DND41_Human0.89036687
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88984653
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.88532059
119GABP_19822575_ChIP-Seq_HepG2_Human0.87870487
120CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87078753
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86732045
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86682925
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86609560
124P300_27268052_Chip-Seq_Bcells_Human0.86550362
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86549464
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85897979
127PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85650974
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84203827
129TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82910532
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82646404
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.81399645
132EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79811977
133BCL6_27268052_Chip-Seq_Bcells_Human0.79708808
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78547323
135CEBPB_22108803_ChIP-Seq_LS180_Human0.78420021
136SPI1_20517297_ChIP-Seq_HL60_Human0.78354056
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78257447
138GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77483371
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74258862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.34688225
2MP0005671_abnormal_response_to3.68522640
3MP0000685_abnormal_immune_system3.68377414
4MP0002396_abnormal_hematopoietic_system3.54772818
5MP0001800_abnormal_humoral_immune3.35741674
6MP0003763_abnormal_thymus_physiology3.30754541
7MP0005387_immune_system_phenotype2.88034923
8MP0001790_abnormal_immune_system2.88034923
9MP0002452_abnormal_antigen_presenting2.85497100
10* MP0002398_abnormal_bone_marrow2.79851279
11* MP0002420_abnormal_adaptive_immunity2.74561514
12MP0009785_altered_susceptibility_to2.74109166
13MP0001819_abnormal_immune_cell2.72550440
14MP0002723_abnormal_immune_serum2.70544255
15MP0005000_abnormal_immune_tolerance2.68473544
16MP0002166_altered_tumor_susceptibility2.52743711
17MP0005025_abnormal_response_to2.51393570
18MP0004808_abnormal_hematopoietic_stem2.43613822
19* MP0000716_abnormal_immune_system2.41965167
20* MP0000689_abnormal_spleen_morphology2.35811606
21MP0006054_spinal_hemorrhage2.35269783
22MP0002148_abnormal_hypersensitivity_rea2.33495885
23MP0003436_decreased_susceptibility_to2.32643843
24MP0005464_abnormal_platelet_physiology2.32097494
25* MP0002722_abnormal_immune_system2.27038137
26MP0002419_abnormal_innate_immunity2.16185690
27* MP0002429_abnormal_blood_cell2.10545363
28MP0000703_abnormal_thymus_morphology2.03051731
29MP0009333_abnormal_splenocyte_physiolog2.00845490
30MP0002405_respiratory_system_inflammati2.00118275
31MP0002006_tumorigenesis1.99034871
32MP0010155_abnormal_intestine_physiology1.90695843
33MP0001853_heart_inflammation1.90129820
34MP0005397_hematopoietic_system_phenotyp1.86919713
35MP0001545_abnormal_hematopoietic_system1.86919713
36MP0010094_abnormal_chromosome_stability1.85446132
37MP0008057_abnormal_DNA_replication1.85062361
38MP0000465_gastrointestinal_hemorrhage1.81688150
39MP0001873_stomach_inflammation1.78596654
40MP0003866_abnormal_defecation1.72760642
41MP0003724_increased_susceptibility_to1.71919487
42MP0005174_abnormal_tail_pigmentation1.68430371
43MP0001845_abnormal_inflammatory_respons1.61219789
44MP0003303_peritoneal_inflammation1.60763584
45MP0005075_abnormal_melanosome_morpholog1.58703176
46MP0000490_abnormal_crypts_of1.54276038
47MP0004947_skin_inflammation1.53650194
48MP0002653_abnormal_ependyma_morphology1.52594567
49MP0003045_fibrosis1.52180176
50MP0004381_abnormal_hair_follicle1.48495956
51MP0003077_abnormal_cell_cycle1.45706602
52MP0002138_abnormal_hepatobiliary_system1.44232522
53MP0003693_abnormal_embryo_hatching1.40664047
54MP0003646_muscle_fatigue1.36117660
55MP0006082_CNS_inflammation1.35667615
56MP0003300_gastrointestinal_ulcer1.33856479
57MP0002933_joint_inflammation1.29234808
58MP0002019_abnormal_tumor_incidence1.27406842
59MP0008004_abnormal_stomach_pH1.27210599
60MP0000569_abnormal_digit_pigmentation1.24173538
61MP0002095_abnormal_skin_pigmentation1.22452843
62MP0009278_abnormal_bone_marrow1.20834895
63MP0008007_abnormal_cellular_replicative1.19700954
64MP0008469_abnormal_protein_level1.18808755
65MP0003111_abnormal_nucleus_morphology1.16572700
66MP0008058_abnormal_DNA_repair1.16270017
67MP0004510_myositis1.15982670
68MP0000858_altered_metastatic_potential1.14030488
69MP0002277_abnormal_respiratory_mucosa1.07120665
70MP0002837_dystrophic_cardiac_calcinosis1.03009838
71MP0004957_abnormal_blastocyst_morpholog1.01322157
72MP0005310_abnormal_salivary_gland0.99849269
73MP0000015_abnormal_ear_pigmentation0.95992331
74MP0001533_abnormal_skeleton_physiology0.94236617
75MP0002132_abnormal_respiratory_system0.92578763
76MP0004043_abnormal_pH_regulation0.88905598
77MP0003172_abnormal_lysosome_physiology0.88745509
78MP0005167_abnormal_blood-brain_barrier0.85913100
79MP0004883_abnormal_blood_vessel0.85841998
80MP0003183_abnormal_peptide_metabolism0.85199346
81MP0003195_calcinosis0.83651278
82MP0003943_abnormal_hepatobiliary_system0.80690693
83MP0010352_gastrointestinal_tract_polyps0.79853337
84MP0000604_amyloidosis0.79778768
85MP0000313_abnormal_cell_death0.79685891
86MP0008875_abnormal_xenobiotic_pharmacok0.78638235
87MP0009764_decreased_sensitivity_to0.78265103
88MP0003448_altered_tumor_morphology0.78189477
89MP0003656_abnormal_erythrocyte_physiolo0.77794526
90MP0001851_eye_inflammation0.77244951
91MP0002009_preneoplasia0.75831449
92MP0010307_abnormal_tumor_latency0.72290157
93MP0002168_other_aberrant_phenotype0.71789383
94MP0009763_increased_sensitivity_to0.71723860
95MP0000343_altered_response_to0.68409107
96MP0002332_abnormal_exercise_endurance0.67476364
97MP0003075_altered_response_to0.67272888
98MP0000249_abnormal_blood_vessel0.66004398
99MP0002693_abnormal_pancreas_physiology0.65528646
100MP0001915_intracranial_hemorrhage0.63613179
101MP0001986_abnormal_taste_sensitivity0.62958364
102MP0003828_pulmonary_edema0.62012346
103MP0005058_abnormal_lysosome_morphology0.61397394
104MP0001879_abnormal_lymphatic_vessel0.60084956
105MP0002998_abnormal_bone_remodeling0.59171232
106MP0008873_increased_physiological_sensi0.58960462
107MP0004130_abnormal_muscle_cell0.55494239
108MP0003191_abnormal_cellular_cholesterol0.55143061
109MP0000477_abnormal_intestine_morphology0.54968019
110MP0000598_abnormal_liver_morphology0.54524263
111MP0000350_abnormal_cell_proliferation0.54252493
112MP0008874_decreased_physiological_sensi0.52902821
113MP0002136_abnormal_kidney_physiology0.52237043
114MP0001765_abnormal_ion_homeostasis0.52061985
115MP0008995_early_reproductive_senescence0.51697559
116MP0005164_abnormal_response_to0.51652049
117MP0009765_abnormal_xenobiotic_induced0.51296502
118MP0001663_abnormal_digestive_system0.50807423
119MP0003786_premature_aging0.50348670
120MP0005166_decreased_susceptibility_to0.50202741
121MP0004147_increased_porphyrin_level0.50128658
122MP0005023_abnormal_wound_healing0.48910628
123MP0005381_digestive/alimentary_phenotyp0.48677283
124MP0001191_abnormal_skin_condition0.48508427
125MP0003795_abnormal_bone_structure0.44305617
126MP0008877_abnormal_DNA_methylation0.43163170

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.19147172
2IgM deficiency (HP:0002850)4.84932542
3Recurrent bronchitis (HP:0002837)4.78404538
4Recurrent viral infections (HP:0004429)4.55606790
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.44610490
6Absent/shortened dynein arms (HP:0200106)4.44610490
7Recurrent abscess formation (HP:0002722)4.44171712
8Thrombocytosis (HP:0001894)4.32662015
9Cellulitis (HP:0100658)4.27282350
10Chronic otitis media (HP:0000389)4.25288856
11Elevated erythrocyte sedimentation rate (HP:0003565)4.24215032
12Abnormal respiratory epithelium morphology (HP:0012253)4.17017144
13Abnormal respiratory motile cilium morphology (HP:0005938)4.17017144
14Panhypogammaglobulinemia (HP:0003139)4.12861303
15Recurrent bacterial skin infections (HP:0005406)4.08282704
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.02875663
17Abnormal ciliary motility (HP:0012262)4.01747784
18T lymphocytopenia (HP:0005403)3.91989599
19IgG deficiency (HP:0004315)3.89517651
20Recurrent fungal infections (HP:0002841)3.89315313
21Abnormal respiratory motile cilium physiology (HP:0012261)3.86132721
22Meningitis (HP:0001287)3.85330418
23Abnormality of T cell number (HP:0011839)3.83728837
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.81930587
25Abnormality of T cells (HP:0002843)3.76604926
26Bronchiectasis (HP:0002110)3.71613959
27Abnormality of B cell number (HP:0010975)3.71512822
28B lymphocytopenia (HP:0010976)3.71512822
29Thyroiditis (HP:0100646)3.54680268
30Abnormality of T cell physiology (HP:0011840)3.48645341
31Lymphopenia (HP:0001888)3.44031456
32Rhinitis (HP:0012384)3.39589027
33Myositis (HP:0100614)3.34953141
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.34647208
35Gastrointestinal stroma tumor (HP:0100723)3.33833418
36Petechiae (HP:0000967)3.26675688
37Verrucae (HP:0200043)3.24538301
38Papilloma (HP:0012740)3.24538301
39Abnormal number of erythroid precursors (HP:0012131)3.23978497
40Recurrent sinusitis (HP:0011108)3.22251269
41Eczematoid dermatitis (HP:0000976)3.20445134
42Inflammation of the large intestine (HP:0002037)3.17818400
43Gastrointestinal inflammation (HP:0004386)3.16581985
44Recurrent cutaneous fungal infections (HP:0011370)3.15984248
45Chronic mucocutaneous candidiasis (HP:0002728)3.15984248
46Abnormality of cells of the erythroid lineage (HP:0012130)3.15855289
47Prolonged bleeding time (HP:0003010)3.12866835
48Recurrent skin infections (HP:0001581)3.12777715
49Chronic sinusitis (HP:0011109)3.09579024
50Severe combined immunodeficiency (HP:0004430)3.09215749
51Colitis (HP:0002583)3.04290843
52IgA deficiency (HP:0002720)3.00541784
53Combined immunodeficiency (HP:0005387)2.95324405
54Vasculitis (HP:0002633)2.88986896
55Abnormality of the fingertips (HP:0001211)2.81530696
56Nasal polyposis (HP:0100582)2.80576644
57Mediastinal lymphadenopathy (HP:0100721)2.75586585
58Chronic bronchitis (HP:0004469)2.75517169
59Lymphoma (HP:0002665)2.74518709
60Spontaneous hematomas (HP:0007420)2.74083285
61Osteomyelitis (HP:0002754)2.73650406
62Abnormality of the nasal mucosa (HP:0000433)2.71549150
63Hypoplasia of the thymus (HP:0000778)2.69969773
64Aplastic anemia (HP:0001915)2.69206629
65Abnormality of the prostate (HP:0008775)2.67156964
66Autoimmune thrombocytopenia (HP:0001973)2.65460030
67Epistaxis (HP:0000421)2.61072252
68Granulocytopenia (HP:0001913)2.60342268
69Eosinophilia (HP:0001880)2.58410475
70Bronchitis (HP:0012387)2.58253897
71Abnormality of eosinophils (HP:0001879)2.57161216
72Reticulocytopenia (HP:0001896)2.56984235
73Recurrent pneumonia (HP:0006532)2.54560360
74Recurrent lower respiratory tract infections (HP:0002783)2.54168234
75Leukocytosis (HP:0001974)2.51363745
76Agnosia (HP:0010524)2.51044889
77Obstructive lung disease (HP:0006536)2.47298330
78Chronic obstructive pulmonary disease (HP:0006510)2.47298330
79Keratoconjunctivitis sicca (HP:0001097)2.46184621
80Keratoconjunctivitis (HP:0001096)2.43602089
81Encephalitis (HP:0002383)2.43480572
82Gastrointestinal infarctions (HP:0005244)2.42744835
83Syringomyelia (HP:0003396)2.39919331
84Spinal cord lesions (HP:0100561)2.39919331
85Increased IgM level (HP:0003496)2.39015320
86Sepsis (HP:0100806)2.36421822
87Chronic diarrhea (HP:0002028)2.34898602
88Increased cerebral lipofuscin (HP:0011813)2.33567530
89Emphysema (HP:0002097)2.28640576
90Purpura (HP:0000979)2.26999646
91Stomatitis (HP:0010280)2.26907414
92Pustule (HP:0200039)2.26268228
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.25896269
94Skin rash (HP:0000988)2.22274094
95Chest pain (HP:0100749)2.20598430
96Neutropenia (HP:0001875)2.20508826
97Stomach cancer (HP:0012126)2.18202921
98Restrictive lung disease (HP:0002091)2.17553312
99Pulmonary embolism (HP:0002204)2.16204611
100Arterial thrombosis (HP:0004420)2.15039480
101Decreased circulating renin level (HP:0003351)2.13705561
102Spondylolisthesis (HP:0003302)2.11969474
103Hematochezia (HP:0002573)2.11388097
104Gangrene (HP:0100758)2.11376957
105Autoimmune hemolytic anemia (HP:0001890)2.11185842
106Abnormality of macrophages (HP:0004311)2.10661987
107Abnormal platelet volume (HP:0011876)2.09108561
108Urticaria (HP:0001025)2.05838764
109Myelodysplasia (HP:0002863)2.02124431
110Abnormal platelet function (HP:0011869)2.01945046
111Impaired platelet aggregation (HP:0003540)2.01945046
112Skin ulcer (HP:0200042)2.01461468
113Recurrent gram-negative bacterial infections (HP:0005420)2.00953761
114Acute myeloid leukemia (HP:0004808)2.00434159
115Periodontitis (HP:0000704)2.00233101
116Hypergammaglobulinemia (HP:0010702)2.00086200
117Interstitial pulmonary disease (HP:0006530)1.99999159
118Orchitis (HP:0100796)1.99263797
119Increased IgE level (HP:0003212)1.98792575
120Amaurosis fugax (HP:0100576)1.97859987
121Pulmonary infiltrates (HP:0002113)1.97621327
122Fatigue (HP:0012378)1.97609109
123Gingival bleeding (HP:0000225)1.96855214
124Hemoptysis (HP:0002105)1.96647257
125Optic neuritis (HP:0100653)1.96335874
126Retrobulbar optic neuritis (HP:0100654)1.96335874
127Abnormality of glycolipid metabolism (HP:0010969)1.95891336
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.95891336
129Recurrent otitis media (HP:0000403)1.95297608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.31314005
2TXK3.19354247
3KIT2.72924697
4JAK32.62959138
5BLK2.54827579
6BTK2.52182694
7ZAP702.36704434
8TEC2.28125249
9EEF2K2.26165745
10SYK2.21449718
11TYK22.03464751
12STK102.03217165
13MAP3K102.03169833
14GRK62.02853758
15CSF1R2.00235446
16FRK1.91020409
17IRAK41.82702965
18ITK1.78636968
19FLT31.77572377
20TBK11.70279279
21IKBKE1.68142587
22CLK11.64134168
23TGFBR11.63757313
24TGFBR21.54631774
25PIK3CG1.53829110
26LCK1.48342728
27MAP3K141.48035034
28LYN1.44460356
29LRRK21.39134536
30NME21.36494261
31MAPK151.33080969
32BMPR21.33061363
33ERN11.26884090
34IKBKB1.23693577
35KDR1.21373310
36MAP2K31.19013708
37FES1.16856630
38NLK1.14232869
39HCK1.14226968
40RPS6KA41.12549603
41PIM11.12138104
42PKN21.11212278
43PRPF4B1.11020694
44RPS6KB21.09559017
45IRAK31.09189607
46RIPK41.07824744
47CSK1.05738601
48GRK71.05524683
49MAP2K21.04724954
50CDC71.02288891
51MAP3K130.99966839
52JAK10.99500970
53TAOK30.99139906
54MATK0.97932245
55CAMKK20.96469496
56IRAK10.95948739
57PASK0.92686041
58STK40.91898475
59VRK10.91808734
60EIF2AK30.89428636
61FGR0.89147076
62NEK20.87930102
63BUB10.87396419
64FGFR30.84490470
65BMPR1B0.82289576
66ATR0.80930104
67WEE10.80807968
68MAP3K120.77973835
69FGFR40.75920567
70CDK40.75634098
71TLK10.72530797
72CDC42BPA0.72064204
73MAP3K80.71512050
74TIE10.71437035
75LATS10.71416566
76MELK0.70492228
77MAPK110.69502056
78CDK80.68978942
79PIM20.67473949
80ACVR1B0.66611452
81PTK2B0.65640687
82MAPK40.65592540
83STK160.64606413
84MAPK120.63694307
85TNK20.61742061
86MST40.61670639
87PRKCQ0.61161378
88PDPK10.60217294
89RPS6KA60.59355454
90ZAK0.58835239
91CAMKK10.56189215
92NEK90.55360468
93CCNB10.55308652
94CDK90.55291178
95TESK20.54556704
96BRD40.54548876
97MAPK70.54377698
98SIK30.54321333
99PRKCH0.53351457
100MARK30.52893760
101CHUK0.50646226
102MAP2K60.50424762
103STK38L0.50207681
104CDK70.50171448
105MAP3K10.49221810
106PRKAA20.49000954
107JAK20.48369239
108DYRK30.46782553
109RPS6KC10.45905758
110RPS6KL10.45905758
111SIK20.45732661
112EIF2AK10.45339826
113ABL10.44644103
114HIPK20.44020167
115ADRBK20.43950250
116TRPM70.43158742
117MARK20.42749879
118MAP3K110.42612047
119MAP3K70.41783269
120MAP3K30.40338833
121NUAK10.38953139
122MAPKAPK20.38458588
123STK240.37134654
124ADRBK10.37113549
125SGK20.37033875
126FYN0.36976937
127PRKCD0.36973860
128AURKB0.35487435
129DAPK20.35130406
130PDK10.34903851
131MAP3K20.34042468
132CDK120.33682783
133BRSK20.33393140
134MAPK30.31593860
135IRAK20.29987791
136CDK60.29403393
137STK110.25556723
138TAOK10.25413866
139KSR20.24733865

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.95434605
2DNA replication_Homo sapiens_hsa030303.40879518
3B cell receptor signaling pathway_Homo sapiens_hsa046622.83258302
4Mismatch repair_Homo sapiens_hsa034302.74284381
5Ribosome_Homo sapiens_hsa030102.71375283
6Base excision repair_Homo sapiens_hsa034102.57330394
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.52758471
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.25767832
9Antigen processing and presentation_Homo sapiens_hsa046122.20512335
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17438360
11Measles_Homo sapiens_hsa051622.11068706
12Leishmaniasis_Homo sapiens_hsa051402.10846727
13Non-homologous end-joining_Homo sapiens_hsa034502.08374954
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05923102
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89199519
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88937764
17Herpes simplex infection_Homo sapiens_hsa051681.81730558
18Homologous recombination_Homo sapiens_hsa034401.73465554
19Osteoclast differentiation_Homo sapiens_hsa043801.71109677
20T cell receptor signaling pathway_Homo sapiens_hsa046601.69217476
21Rheumatoid arthritis_Homo sapiens_hsa053231.67169234
22Nucleotide excision repair_Homo sapiens_hsa034201.55558591
23Spliceosome_Homo sapiens_hsa030401.53682275
24Allograft rejection_Homo sapiens_hsa053301.52947347
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48447618
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39538655
27Graft-versus-host disease_Homo sapiens_hsa053321.38724696
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.33241409
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31808378
30Platelet activation_Homo sapiens_hsa046111.24644044
31Shigellosis_Homo sapiens_hsa051311.19549041
32Pyrimidine metabolism_Homo sapiens_hsa002401.19107364
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17511455
34Viral myocarditis_Homo sapiens_hsa054161.17330782
35Legionellosis_Homo sapiens_hsa051341.17159115
36Other glycan degradation_Homo sapiens_hsa005111.15648709
37Influenza A_Homo sapiens_hsa051641.15458810
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13635659
39Hepatitis B_Homo sapiens_hsa051611.11651999
40Cell cycle_Homo sapiens_hsa041101.08880029
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08798735
42Acute myeloid leukemia_Homo sapiens_hsa052211.08275748
43Toxoplasmosis_Homo sapiens_hsa051451.07979235
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.07079645
45Epstein-Barr virus infection_Homo sapiens_hsa051691.03382177
46Fanconi anemia pathway_Homo sapiens_hsa034601.03343710
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03222352
48Chemokine signaling pathway_Homo sapiens_hsa040620.99558493
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98740191
50RNA degradation_Homo sapiens_hsa030180.98479037
51Asthma_Homo sapiens_hsa053100.98235949
52Apoptosis_Homo sapiens_hsa042100.97813444
53RNA polymerase_Homo sapiens_hsa030200.97511131
54Pertussis_Homo sapiens_hsa051330.97085853
55Tuberculosis_Homo sapiens_hsa051520.96251075
56p53 signaling pathway_Homo sapiens_hsa041150.96209974
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93702570
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92045385
59Malaria_Homo sapiens_hsa051440.89859972
60Lysosome_Homo sapiens_hsa041420.89437314
61HTLV-I infection_Homo sapiens_hsa051660.86816982
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84653242
63Viral carcinogenesis_Homo sapiens_hsa052030.84625481
64Dorso-ventral axis formation_Homo sapiens_hsa043200.83847040
65Chronic myeloid leukemia_Homo sapiens_hsa052200.82857976
66Phagosome_Homo sapiens_hsa041450.82067384
67Pancreatic cancer_Homo sapiens_hsa052120.80855198
68Staphylococcus aureus infection_Homo sapiens_hsa051500.80830032
69Systemic lupus erythematosus_Homo sapiens_hsa053220.78707008
70RNA transport_Homo sapiens_hsa030130.75135441
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74336241
72Non-small cell lung cancer_Homo sapiens_hsa052230.73532580
73TNF signaling pathway_Homo sapiens_hsa046680.69472949
74Pentose phosphate pathway_Homo sapiens_hsa000300.68560069
75Autoimmune thyroid disease_Homo sapiens_hsa053200.68503114
76Proteasome_Homo sapiens_hsa030500.67731842
77Sphingolipid metabolism_Homo sapiens_hsa006000.64629528
78Salmonella infection_Homo sapiens_hsa051320.64510789
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64334353
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63731427
81One carbon pool by folate_Homo sapiens_hsa006700.63038646
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61774670
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.60420909
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.59828319
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58721540
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58355841
87Small cell lung cancer_Homo sapiens_hsa052220.57817722
88Linoleic acid metabolism_Homo sapiens_hsa005910.57227142
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56790954
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53776273
91Purine metabolism_Homo sapiens_hsa002300.53295851
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52863445
93mRNA surveillance pathway_Homo sapiens_hsa030150.52490390
94Hepatitis C_Homo sapiens_hsa051600.52205368
95Basal transcription factors_Homo sapiens_hsa030220.51785689
96ABC transporters_Homo sapiens_hsa020100.51225565
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51189110
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49999769
99N-Glycan biosynthesis_Homo sapiens_hsa005100.48514072
100Arachidonic acid metabolism_Homo sapiens_hsa005900.44895895
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44517000
102Colorectal cancer_Homo sapiens_hsa052100.44507147
103Phototransduction_Homo sapiens_hsa047440.44348448
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.44185761
105Type I diabetes mellitus_Homo sapiens_hsa049400.40588113
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40140409
107Notch signaling pathway_Homo sapiens_hsa043300.38126825
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38046081
109African trypanosomiasis_Homo sapiens_hsa051430.36105075
110FoxO signaling pathway_Homo sapiens_hsa040680.35425399
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34565032
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.33731859
113Choline metabolism in cancer_Homo sapiens_hsa052310.32833415
114Type II diabetes mellitus_Homo sapiens_hsa049300.32647394
115Caffeine metabolism_Homo sapiens_hsa002320.31688463
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.31589615
117Inositol phosphate metabolism_Homo sapiens_hsa005620.31141939
118Protein export_Homo sapiens_hsa030600.30956379
119Collecting duct acid secretion_Homo sapiens_hsa049660.28707490
120Ether lipid metabolism_Homo sapiens_hsa005650.25269294
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.24824292
122HIF-1 signaling pathway_Homo sapiens_hsa040660.24291370
123Insulin resistance_Homo sapiens_hsa049310.24183924
124Thyroid cancer_Homo sapiens_hsa052160.23428706
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23320716
126Prolactin signaling pathway_Homo sapiens_hsa049170.22207629
127Chemical carcinogenesis_Homo sapiens_hsa052040.21974735
128VEGF signaling pathway_Homo sapiens_hsa043700.21710242
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20928259
130mTOR signaling pathway_Homo sapiens_hsa041500.20500762
131Taste transduction_Homo sapiens_hsa047420.18913029
132Glycerolipid metabolism_Homo sapiens_hsa005610.17974711
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17952497

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