KLHL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63010938
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60995497
3nucleobase catabolic process (GO:0046113)4.30143687
4regulation of synaptic vesicle exocytosis (GO:2000300)4.17495572
5neuron cell-cell adhesion (GO:0007158)4.17167784
6synaptic vesicle exocytosis (GO:0016079)4.11038970
7vocalization behavior (GO:0071625)4.04993278
8synaptic vesicle maturation (GO:0016188)4.04460692
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.81410243
10layer formation in cerebral cortex (GO:0021819)3.79989535
11regulation of glutamate receptor signaling pathway (GO:1900449)3.70346801
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67829866
13locomotory exploration behavior (GO:0035641)3.67720000
14regulation of synaptic vesicle transport (GO:1902803)3.66478175
15neuron recognition (GO:0008038)3.64866170
16behavioral response to nicotine (GO:0035095)3.59356835
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.58478869
18protein localization to synapse (GO:0035418)3.54355056
19gamma-aminobutyric acid transport (GO:0015812)3.54068972
20dendritic spine morphogenesis (GO:0060997)3.52538517
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51232294
22regulation of synapse structural plasticity (GO:0051823)3.49576036
23glutamate secretion (GO:0014047)3.46243424
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41781528
25DNA double-strand break processing (GO:0000729)3.39280946
26axonal fasciculation (GO:0007413)3.36252865
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34541728
28response to pheromone (GO:0019236)3.33665939
29neurotransmitter secretion (GO:0007269)3.33250362
30detection of calcium ion (GO:0005513)3.28274760
31positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25628872
32dendrite morphogenesis (GO:0048813)3.25523355
33negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25267996
34innervation (GO:0060384)3.24648356
35postsynaptic membrane organization (GO:0001941)3.24186584
36exploration behavior (GO:0035640)3.21212695
37neurotransmitter-gated ion channel clustering (GO:0072578)3.20148763
38central nervous system projection neuron axonogenesis (GO:0021952)3.18340528
39COPI coating of Golgi vesicle (GO:0048205)3.17594159
40Golgi transport vesicle coating (GO:0048200)3.17594159
41synaptic transmission, glutamatergic (GO:0035249)3.14383548
42positive regulation of synapse maturation (GO:0090129)3.13577843
43presynaptic membrane assembly (GO:0097105)3.12294070
44regulation of neuronal synaptic plasticity (GO:0048168)3.09255279
45neuron-neuron synaptic transmission (GO:0007270)3.06682181
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.05959772
47activation of protein kinase A activity (GO:0034199)3.04733153
48insulin secretion (GO:0030073)3.02584926
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02491887
50synaptic vesicle endocytosis (GO:0048488)2.98022331
51positive regulation of mitochondrial fission (GO:0090141)2.94514501
52pyrimidine nucleobase catabolic process (GO:0006208)2.94247551
53presynaptic membrane organization (GO:0097090)2.93132477
54cerebellar Purkinje cell layer development (GO:0021680)2.91970070
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91207290
56establishment of mitochondrion localization (GO:0051654)2.90643997
57positive regulation of dendritic spine morphogenesis (GO:0061003)2.90045318
58protein localization to cilium (GO:0061512)2.89592359
59proline transport (GO:0015824)2.89203579
60nonmotile primary cilium assembly (GO:0035058)2.88675715
61neural tube formation (GO:0001841)2.86791908
62regulation of vesicle fusion (GO:0031338)2.86209909
63cullin deneddylation (GO:0010388)2.85774008
64glutamate receptor signaling pathway (GO:0007215)2.84959463
65intraciliary transport (GO:0042073)2.82832489
66regulation of action potential (GO:0098900)2.82703158
67synapse assembly (GO:0007416)2.81899110
68striatum development (GO:0021756)2.81652922
69regulation of development, heterochronic (GO:0040034)2.80462005
70cell migration in hindbrain (GO:0021535)2.79983958
71cerebellar Purkinje cell differentiation (GO:0021702)2.79436250
72positive regulation of synapse assembly (GO:0051965)2.79169155
73retinal cone cell development (GO:0046549)2.78494288
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78302001
75neuronal action potential propagation (GO:0019227)2.76099696
76cerebellum development (GO:0021549)2.75791699
77cell communication by electrical coupling (GO:0010644)2.74734843
78vesicle transport along microtubule (GO:0047496)2.74009748
79negative regulation of DNA recombination (GO:0045910)2.73590150
80DNA damage response, detection of DNA damage (GO:0042769)2.72856579
81transmission of nerve impulse (GO:0019226)2.72816416
82protein polyglutamylation (GO:0018095)2.72381537
83neurotransmitter transport (GO:0006836)2.70854074
84startle response (GO:0001964)2.70079982
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70041912
86head development (GO:0060322)2.68735032
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68564812
88long-term memory (GO:0007616)2.68294006
89membrane depolarization during action potential (GO:0086010)2.65854326
90regulation of neurotransmitter secretion (GO:0046928)2.65824678
91long-term synaptic potentiation (GO:0060291)2.65641085
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64455923
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.64125836
94regulation of calcium ion-dependent exocytosis (GO:0017158)2.63456867
95limb bud formation (GO:0060174)2.63200064
96regulation of postsynaptic membrane potential (GO:0060078)2.63162746
97positive regulation of membrane potential (GO:0045838)2.63081087
98positive regulation of action potential (GO:0045760)2.62495272
99neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61128248
100regulation of dendritic spine morphogenesis (GO:0061001)2.60956084
101auditory behavior (GO:0031223)2.60784723
102histone H2A acetylation (GO:0043968)2.60003538
103regulation of synaptic transmission, GABAergic (GO:0032228)2.59842603
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.59831931
105somite development (GO:0061053)2.59449586
106regulation of synapse maturation (GO:0090128)2.58913070
107dendrite development (GO:0016358)2.58791860
108protein deneddylation (GO:0000338)2.58470731
109calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.58271888
110regulation of synapse assembly (GO:0051963)2.58017418
111synapse organization (GO:0050808)2.57975337
112organelle transport along microtubule (GO:0072384)2.57557217
113prepulse inhibition (GO:0060134)2.57514322
114inner ear receptor cell development (GO:0060119)2.57345300
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57009126
116regulation of respiratory system process (GO:0044065)2.56167659
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55784390
118hippocampus development (GO:0021766)2.55701833
119regulation of meiosis I (GO:0060631)2.54100262
120cerebral cortex radially oriented cell migration (GO:0021799)2.53835310
121urinary tract smooth muscle contraction (GO:0014848)2.53136032
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.53085080
123positive regulation of potassium ion transport (GO:0043268)2.53008502
124dendritic spine organization (GO:0097061)2.52341351
125establishment of synaptic vesicle localization (GO:0097480)2.51982604
126synaptic vesicle transport (GO:0048489)2.51982604
127membrane repolarization during action potential (GO:0086011)2.51495394
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50338799
129regulation of mitotic spindle checkpoint (GO:1903504)2.50338799
130DNA integration (GO:0015074)2.48623300
131regulation of helicase activity (GO:0051095)2.46792984
132olfactory bulb development (GO:0021772)2.41855738
133pyrimidine dimer repair (GO:0006290)2.40703608
134glycosphingolipid biosynthetic process (GO:0006688)2.35957391
135protein-cofactor linkage (GO:0018065)2.34843045
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.34217245
137cilium morphogenesis (GO:0060271)2.33648827
138water-soluble vitamin biosynthetic process (GO:0042364)2.32442525
139sympathetic nervous system development (GO:0048485)2.31042849
140platelet dense granule organization (GO:0060155)2.30844843
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.30667162
142neurofilament cytoskeleton organization (GO:0060052)2.28899190
143short-term memory (GO:0007614)2.28823691
144regulation of timing of cell differentiation (GO:0048505)2.28718143
145retinal ganglion cell axon guidance (GO:0031290)2.28576338
146negative regulation of oligodendrocyte differentiation (GO:0048715)2.28491998
147NADH dehydrogenase complex assembly (GO:0010257)2.27695470
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.27695470
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.27695470
150positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.25431734
151mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.25431734
152negative regulation of telomere maintenance (GO:0032205)2.25013029
153chromatin remodeling at centromere (GO:0031055)2.24951115
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.24899349
155somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24718311
156somatic hypermutation of immunoglobulin genes (GO:0016446)2.24718311
157regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.24356010
158regulation of telomere maintenance (GO:0032204)2.24280776
159C4-dicarboxylate transport (GO:0015740)2.24038975
160reflex (GO:0060004)2.21930979
161regulation of collateral sprouting (GO:0048670)2.20865691
162substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.19868319
163substrate-independent telencephalic tangential migration (GO:0021826)2.19868319
164nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.19164234
165L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.18153841
166spinal cord development (GO:0021510)2.16989926
167regulation of cilium movement (GO:0003352)2.15551615
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.15224085
169anterograde axon cargo transport (GO:0008089)2.14874431
170mechanosensory behavior (GO:0007638)2.13575643
171regulation of posttranscriptional gene silencing (GO:0060147)2.13079887
172regulation of gene silencing by miRNA (GO:0060964)2.13079887
173regulation of gene silencing by RNA (GO:0060966)2.13079887
174epithelial cilium movement (GO:0003351)2.12527591
175negative regulation of translation, ncRNA-mediated (GO:0040033)2.12404071
176regulation of translation, ncRNA-mediated (GO:0045974)2.12404071
177negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.12404071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21962666
2GBX2_23144817_ChIP-Seq_PC3_Human3.76285789
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67032493
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62239846
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.52288703
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.50133985
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48750674
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47079715
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36908992
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29421279
11* SALL1_21062744_ChIP-ChIP_HESCs_Human2.28037972
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25009431
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24477235
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23798171
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16829166
16EWS_26573619_Chip-Seq_HEK293_Human2.15897617
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15651032
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13312539
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13312539
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13064362
21IGF1R_20145208_ChIP-Seq_DFB_Human2.10234397
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07453369
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.05885674
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02716975
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.01074937
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.00384717
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98405977
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96878882
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92299943
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.92093972
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91887473
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.91379412
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90540054
34ZNF274_21170338_ChIP-Seq_K562_Hela1.89590188
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88259953
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86167796
37DROSHA_22980978_ChIP-Seq_HELA_Human1.82670178
38TAF15_26573619_Chip-Seq_HEK293_Human1.81737170
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78767248
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.76341187
41SMAD4_21799915_ChIP-Seq_A2780_Human1.75868573
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73182531
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70358342
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68537452
45* P300_19829295_ChIP-Seq_ESCs_Human1.68281460
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63403582
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63372955
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.61260866
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.58477070
50IRF1_19129219_ChIP-ChIP_H3396_Human1.56981416
51FUS_26573619_Chip-Seq_HEK293_Human1.53429863
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51954293
53* PIAS1_25552417_ChIP-Seq_VCAP_Human1.50303331
54VDR_22108803_ChIP-Seq_LS180_Human1.50292302
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50291507
56RNF2_27304074_Chip-Seq_NSC_Mouse1.48029727
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47750082
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46944242
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.45679882
60* STAT3_23295773_ChIP-Seq_U87_Human1.44964434
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44144413
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.42360587
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41398328
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41392225
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40774601
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40323248
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39426184
68CBP_20019798_ChIP-Seq_JUKART_Human1.39426184
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38125919
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.36710617
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33155824
72MYC_18940864_ChIP-ChIP_HL60_Human1.32803383
73AR_25329375_ChIP-Seq_VCAP_Human1.32517933
74ELK1_19687146_ChIP-ChIP_HELA_Human1.32071947
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30164089
76AR_21572438_ChIP-Seq_LNCaP_Human1.29168816
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28605628
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27087676
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25027438
80SOX2_16153702_ChIP-ChIP_HESCs_Human1.24625549
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23839915
82AR_19668381_ChIP-Seq_PC3_Human1.21665437
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20499010
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19471003
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19450929
86* TCF4_23295773_ChIP-Seq_U87_Human1.19218086
87RUNX2_22187159_ChIP-Seq_PCA_Human1.15686029
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15179072
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14841019
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12999408
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12585316
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.12440374
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12318908
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11581390
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10112135
96TP53_22573176_ChIP-Seq_HFKS_Human1.09594532
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09410401
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.09143884
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08099936
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08026030
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07495714
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06391791
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.06089400
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.06088361
105ER_23166858_ChIP-Seq_MCF-7_Human1.05699034
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05659619
107JUN_21703547_ChIP-Seq_K562_Human1.05249948
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03975420
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.03103187
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02985770
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02925413
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02406318
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01691874
114* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01633582
115BCAT_22108803_ChIP-Seq_LS180_Human1.01600151
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01566743
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01206915
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00983507
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00983507
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00332917
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.99610051
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.99505061
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99217592
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.99057563
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98948480
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97868263
127SOX9_26525672_Chip-Seq_HEART_Mouse0.97699230
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97539042
129SOX2_19829295_ChIP-Seq_ESCs_Human0.97413545
130NANOG_19829295_ChIP-Seq_ESCs_Human0.97413545
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96979258
132TCF4_22108803_ChIP-Seq_LS180_Human0.95921585
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95443609
134TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94614374
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.94436404
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.94214273
137TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93961876
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93735604
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93664951
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93018832
141CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92923388
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92385475

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.74616655
2MP0003880_abnormal_central_pattern3.29220271
3MP0004270_analgesia3.05014109
4MP0003635_abnormal_synaptic_transmissio2.92450440
5MP0002102_abnormal_ear_morphology2.87859391
6MP0003122_maternal_imprinting2.70335118
7MP0009780_abnormal_chondrocyte_physiolo2.60357572
8MP0005646_abnormal_pituitary_gland2.56606320
9MP0008877_abnormal_DNA_methylation2.54751654
10MP0002063_abnormal_learning/memory/cond2.47738090
11MP0005645_abnormal_hypothalamus_physiol2.38724736
12MP0000013_abnormal_adipose_tissue2.33335647
13MP0002909_abnormal_adrenal_gland2.28610197
14MP0009745_abnormal_behavioral_response2.26635712
15MP0003787_abnormal_imprinting2.22557678
16MP0002734_abnormal_mechanical_nocicepti2.18366391
17MP0002572_abnormal_emotion/affect_behav2.15586155
18MP0006276_abnormal_autonomic_nervous2.13131713
19MP0000778_abnormal_nervous_system2.12839647
20MP0010386_abnormal_urinary_bladder2.07444427
21MP0002064_seizures2.03660110
22MP0003283_abnormal_digestive_organ2.02296595
23MP0005423_abnormal_somatic_nervous1.96801315
24MP0009046_muscle_twitch1.94302483
25MP0002184_abnormal_innervation1.88539074
26MP0002837_dystrophic_cardiac_calcinosis1.84477441
27MP0000049_abnormal_middle_ear1.81434814
28MP0002735_abnormal_chemical_nociception1.80440624
29MP0001968_abnormal_touch/_nociception1.79962735
30MP0002272_abnormal_nervous_system1.78768973
31MP0006072_abnormal_retinal_apoptosis1.78378371
32MP0002557_abnormal_social/conspecific_i1.72547862
33MP0002638_abnormal_pupillary_reflex1.72202737
34MP0001529_abnormal_vocalization1.67301838
35MP0001486_abnormal_startle_reflex1.66918885
36MP0000569_abnormal_digit_pigmentation1.64617633
37MP0003183_abnormal_peptide_metabolism1.64302556
38MP0002733_abnormal_thermal_nociception1.62959219
39MP0003718_maternal_effect1.62257052
40MP0004043_abnormal_pH_regulation1.61917603
41MP0000631_abnormal_neuroendocrine_gland1.59869722
42MP0001984_abnormal_olfaction1.58771928
43MP0004811_abnormal_neuron_physiology1.54554691
44MP0002067_abnormal_sensory_capabilities1.54428291
45MP0003937_abnormal_limbs/digits/tail_de1.54350563
46MP0003121_genomic_imprinting1.53919665
47MP0000955_abnormal_spinal_cord1.52596449
48MP0001502_abnormal_circadian_rhythm1.51633995
49MP0005386_behavior/neurological_phenoty1.47883568
50MP0004924_abnormal_behavior1.47883568
51MP0008058_abnormal_DNA_repair1.47257115
52MP0001970_abnormal_pain_threshold1.45927125
53MP0005379_endocrine/exocrine_gland_phen1.45828419
54MP0001188_hyperpigmentation1.45496209
55MP0002234_abnormal_pharynx_morphology1.45412098
56MP0006292_abnormal_olfactory_placode1.44108754
57MP0001440_abnormal_grooming_behavior1.42764244
58MP0002822_catalepsy1.42288937
59MP0001501_abnormal_sleep_pattern1.39750787
60MP0004133_heterotaxia1.38661512
61MP0003567_abnormal_fetal_cardiomyocyte1.35737838
62MP0001944_abnormal_pancreas_morphology1.32488056
63MP0002736_abnormal_nociception_after1.29711205
64MP0001293_anophthalmia1.28916516
65MP0002882_abnormal_neuron_morphology1.27699522
66MP0002693_abnormal_pancreas_physiology1.24384370
67MP0002233_abnormal_nose_morphology1.24247148
68MP0003136_yellow_coat_color1.21350406
69MP0003123_paternal_imprinting1.19412331
70MP0004145_abnormal_muscle_electrophysio1.16397113
71MP0003879_abnormal_hair_cell1.14885978
72MP0003938_abnormal_ear_development1.12180343
73MP0008569_lethality_at_weaning1.12157249
74MP0002066_abnormal_motor_capabilities/c1.09077227
75MP0005499_abnormal_olfactory_system1.08777753
76MP0005394_taste/olfaction_phenotype1.08777753
77MP0000678_abnormal_parathyroid_gland1.08035397
78MP0002152_abnormal_brain_morphology1.07807667
79MP0002751_abnormal_autonomic_nervous1.07499165
80MP0004233_abnormal_muscle_weight1.05145521
81MP0002938_white_spotting1.03739283
82MP0001485_abnormal_pinna_reflex1.03705632
83MP0004858_abnormal_nervous_system1.01670321
84MP0005551_abnormal_eye_electrophysiolog0.99766833
85MP0005187_abnormal_penis_morphology0.99388927
86MP0003755_abnormal_palate_morphology0.97995959
87MP0006035_abnormal_mitochondrial_morpho0.96710924
88MP0002069_abnormal_eating/drinking_beha0.95960069
89MP0004085_abnormal_heartbeat0.95877774
90MP0001299_abnormal_eye_distance/0.94915842
91MP0001286_abnormal_eye_development0.94652654
92MP0005253_abnormal_eye_physiology0.94622296
93MP0000003_abnormal_adipose_tissue0.93969526
94MP0003119_abnormal_digestive_system0.91378545
95MP0000026_abnormal_inner_ear0.89873910
96MP0008789_abnormal_olfactory_epithelium0.89475487
97MP0000647_abnormal_sebaceous_gland0.88873525
98MP0004215_abnormal_myocardial_fiber0.88841197
99MP0008961_abnormal_basal_metabolism0.88137971
100MP0005195_abnormal_posterior_eye0.87882314
101MP0002877_abnormal_melanocyte_morpholog0.87789848
102MP0002653_abnormal_ependyma_morphology0.87513306
103MP0001177_atelectasis0.85886861
104MP0000751_myopathy0.85578261
105MP0008995_early_reproductive_senescence0.85538696
106MP0004885_abnormal_endolymph0.84686458
107MP0002078_abnormal_glucose_homeostasis0.84045567
108MP0003221_abnormal_cardiomyocyte_apopto0.83973306
109MP0005391_vision/eye_phenotype0.83595330
110MP0003693_abnormal_embryo_hatching0.82884816
111MP0002697_abnormal_eye_size0.82570535
112MP0010094_abnormal_chromosome_stability0.82531529
113MP0002876_abnormal_thyroid_physiology0.82313010
114MP0008932_abnormal_embryonic_tissue0.81129865
115MP0001905_abnormal_dopamine_level0.80483741
116MP0004142_abnormal_muscle_tone0.80362400
117MP0001986_abnormal_taste_sensitivity0.79614338
118MP0003861_abnormal_nervous_system0.79172622
119MP0000427_abnormal_hair_cycle0.78378387
120MP0000537_abnormal_urethra_morphology0.78145988
121MP0005248_abnormal_Harderian_gland0.77858696
122MP0003011_delayed_dark_adaptation0.76967163
123MP0003633_abnormal_nervous_system0.76260871
124MP0002163_abnormal_gland_morphology0.76182976
125MP0001963_abnormal_hearing_physiology0.76036058
126MP0000372_irregular_coat_pigmentation0.75809117
127MP0002752_abnormal_somatic_nervous0.75801838
128MP0003890_abnormal_embryonic-extraembry0.73827962
129MP0005535_abnormal_body_temperature0.71735177
130MP0002210_abnormal_sex_determination0.71662660
131MP0003698_abnormal_male_reproductive0.71641969
132MP0001270_distended_abdomen0.68993637
133MP0003137_abnormal_impulse_conducting0.68514246

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.72103070
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.89720384
3Abnormality of the labia minora (HP:0012880)3.78325022
4Visual hallucinations (HP:0002367)3.68932290
5Pheochromocytoma (HP:0002666)3.43859574
6Epileptic encephalopathy (HP:0200134)3.31735678
7Focal seizures (HP:0007359)3.29515066
8Hyperinsulinemic hypoglycemia (HP:0000825)3.28590049
9Agitation (HP:0000713)3.28127489
10Myokymia (HP:0002411)3.16163443
11Hypoglycemic seizures (HP:0002173)3.10727031
12Epileptiform EEG discharges (HP:0011182)3.03087288
13Colon cancer (HP:0003003)3.02589240
14EEG with generalized epileptiform discharges (HP:0011198)3.02299741
15Neuroendocrine neoplasm (HP:0100634)3.00943780
16Atonic seizures (HP:0010819)2.94232514
17Cortical dysplasia (HP:0002539)2.93045513
18Symptomatic seizures (HP:0011145)2.90611019
19Pancreatic cysts (HP:0001737)2.89628541
20Hypsarrhythmia (HP:0002521)2.89001792
21Progressive cerebellar ataxia (HP:0002073)2.86188969
22Febrile seizures (HP:0002373)2.85782714
23Pendular nystagmus (HP:0012043)2.81134784
24Drooling (HP:0002307)2.80092360
25Excessive salivation (HP:0003781)2.80092360
26Hepatoblastoma (HP:0002884)2.77706519
27Pancreatic fibrosis (HP:0100732)2.76031926
28Absence seizures (HP:0002121)2.72522172
29True hermaphroditism (HP:0010459)2.70935236
30Limb dystonia (HP:0002451)2.70787640
31Hyperventilation (HP:0002883)2.61323103
32Anxiety (HP:0000739)2.54562254
33Dialeptic seizures (HP:0011146)2.50724286
34Abnormality of calcium-phosphate metabolism (HP:0100530)2.50259526
35Gait imbalance (HP:0002141)2.50024343
36Nephronophthisis (HP:0000090)2.46972478
37Megalencephaly (HP:0001355)2.44615474
38Ankle clonus (HP:0011448)2.43931819
39Shoulder girdle muscle weakness (HP:0003547)2.41511171
40Depression (HP:0000716)2.39982038
41Broad-based gait (HP:0002136)2.35953627
42Generalized tonic-clonic seizures (HP:0002069)2.35316234
43Truncal ataxia (HP:0002078)2.34315388
44Hyperglycemia (HP:0003074)2.28278385
45Hyperglycinemia (HP:0002154)2.28250663
46Protruding tongue (HP:0010808)2.25132610
47Insulin-resistant diabetes mellitus (HP:0000831)2.21669553
48Poor eye contact (HP:0000817)2.21655121
49Thyroid-stimulating hormone excess (HP:0002925)2.21015258
50Pachygyria (HP:0001302)2.18904135
51Hypothermia (HP:0002045)2.18576918
52Oligodactyly (hands) (HP:0001180)2.17467788
53Failure to thrive in infancy (HP:0001531)2.17015683
54Hemiparesis (HP:0001269)2.15912109
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.13770932
56Retinal dysplasia (HP:0007973)2.12923417
57Menstrual irregularities (HP:0000858)2.10527339
58Congenital primary aphakia (HP:0007707)2.10460738
59Optic nerve hypoplasia (HP:0000609)2.10207385
60Ependymoma (HP:0002888)2.09991003
61Papillary thyroid carcinoma (HP:0002895)2.09439958
62Abolished electroretinogram (ERG) (HP:0000550)2.09161614
63Medial flaring of the eyebrow (HP:0010747)2.07405167
64Inability to walk (HP:0002540)2.07117864
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06052075
66Abnormality of alanine metabolism (HP:0010916)2.04976841
67Hyperalaninemia (HP:0003348)2.04976841
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04976841
69Papilledema (HP:0001085)2.03744972
70Stenosis of the external auditory canal (HP:0000402)2.03726195
71Short tibia (HP:0005736)2.03512691
72Septo-optic dysplasia (HP:0100842)2.02317470
73Exotropia (HP:0000577)2.01863240
74Blue irides (HP:0000635)2.00368634
75Acute necrotizing encephalopathy (HP:0006965)1.99999400
76Nephrogenic diabetes insipidus (HP:0009806)1.99927817
77Methylmalonic acidemia (HP:0002912)1.99261317
78Amblyopia (HP:0000646)1.99240982
79Chronic hepatic failure (HP:0100626)1.98166304
80Abnormality of the renal medulla (HP:0100957)1.98098497
81Abnormal pancreas size (HP:0012094)1.97512576
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.97182793
83Lissencephaly (HP:0001339)1.96482892
84Postaxial hand polydactyly (HP:0001162)1.96325752
85Esotropia (HP:0000565)1.96092790
86Impaired vibration sensation in the lower limbs (HP:0002166)1.93451183
87Decreased circulating renin level (HP:0003351)1.92287874
88Progressive inability to walk (HP:0002505)1.92136949
89Neoplasm of the heart (HP:0100544)1.91512149
90Gaze-evoked nystagmus (HP:0000640)1.90551809
91Astrocytoma (HP:0009592)1.89593069
92Abnormality of the astrocytes (HP:0100707)1.89593069
93Split foot (HP:0001839)1.89287311
94Impaired social interactions (HP:0000735)1.87903429
95Abnormal social behavior (HP:0012433)1.87903429
96Absent speech (HP:0001344)1.87829864
97Prolonged QT interval (HP:0001657)1.87419730
98Preaxial hand polydactyly (HP:0001177)1.86808715
99Impaired smooth pursuit (HP:0007772)1.86281886
100Ketoacidosis (HP:0001993)1.86094538
101Abnormality of the fovea (HP:0000493)1.85602025
102Intestinal atresia (HP:0011100)1.85599203
103Specific learning disability (HP:0001328)1.85521134
104Abnormality of the metopic suture (HP:0005556)1.85295947
105Anencephaly (HP:0002323)1.84301154
106Acute encephalopathy (HP:0006846)1.83620820
107Neoplasm of the peripheral nervous system (HP:0100007)1.83042977
108Pancreatic islet-cell hyperplasia (HP:0004510)1.82198751
109Broad foot (HP:0001769)1.81653058
110Polyphagia (HP:0002591)1.81212128
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.80822970
112Hypoplasia of the fovea (HP:0007750)1.80822970
113Neoplasm of the adrenal gland (HP:0100631)1.80547039
114Supernumerary spleens (HP:0009799)1.80234819
115Postaxial foot polydactyly (HP:0001830)1.79515485
116Sclerocornea (HP:0000647)1.78850598
117Progressive macrocephaly (HP:0004481)1.78841016
118Genetic anticipation (HP:0003743)1.78462598
119Occipital encephalocele (HP:0002085)1.77767697
120Genital tract atresia (HP:0001827)1.76979096
121Narrow forehead (HP:0000341)1.76677213
122Hypoplastic female external genitalia (HP:0012815)1.76000617
123Humeroradial synostosis (HP:0003041)1.75540955
124Synostosis involving the elbow (HP:0003938)1.75540955
125Action tremor (HP:0002345)1.75437774
126Abnormal EKG (HP:0003115)1.74982340
127Bifid tongue (HP:0010297)1.74713618
128Poor coordination (HP:0002370)1.74064222
129Abnormal eating behavior (HP:0100738)1.74055598
130Supranuclear gaze palsy (HP:0000605)1.73851319
131Urinary bladder sphincter dysfunction (HP:0002839)1.72712979
132Vaginal atresia (HP:0000148)1.72685773
133Small hand (HP:0200055)1.72349797
134Chorioretinal atrophy (HP:0000533)1.71195759
135Prominent metopic ridge (HP:0005487)1.71185736
136Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70140791
137Hypoplasia of the brainstem (HP:0002365)1.70140791
138Abnormality of salivation (HP:0100755)1.69794684
139Large for gestational age (HP:0001520)1.69539509
140Patellar aplasia (HP:0006443)1.69438641
141Abnormal mitochondria in muscle tissue (HP:0008316)1.69058657
142Abnormality of endocrine pancreas physiology (HP:0012093)1.68720568
143Abnormality of the pancreatic islet cells (HP:0006476)1.68720568
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.68668195
145Labial hypoplasia (HP:0000066)1.68288236
146Rimmed vacuoles (HP:0003805)1.68283588
147Dysdiadochokinesis (HP:0002075)1.68261122
148Open mouth (HP:0000194)1.67852951
149Micropenis (HP:0000054)1.67511635
150Central scotoma (HP:0000603)1.65660365
151Molar tooth sign on MRI (HP:0002419)1.65250950
152Abnormality of midbrain morphology (HP:0002418)1.65250950
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.64996218
154Hyperthyroidism (HP:0000836)1.64598841
155Abnormality of the ileum (HP:0001549)1.64521261
156Renal hypoplasia (HP:0000089)1.64453741
157Meckel diverticulum (HP:0002245)1.64381590
158Type II lissencephaly (HP:0007260)1.63670263
159Spastic tetraplegia (HP:0002510)1.63015197
160Muscular hypotonia of the trunk (HP:0008936)1.63000830
161Polymicrogyria (HP:0002126)1.62905520
162Anophthalmia (HP:0000528)1.62891622
163Glioma (HP:0009733)1.62668105
164Hypoventilation (HP:0002791)1.62481028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.60530129
2NTRK33.86415322
3INSRR3.41095532
4TRIM283.00491385
5MAP4K22.98912312
6WNK32.64202075
7MAP3K42.58548782
8EPHA42.54981902
9CASK2.48034954
10ERBB32.27134675
11MINK12.25290538
12MAP2K72.25253291
13MAP3K92.17545970
14SRPK12.07850489
15NTRK22.06362546
16MAPK151.91419858
17MAPK131.87052563
18KSR11.86399211
19CSNK1G11.85380658
20BCR1.81556800
21CSNK1A1L1.75852690
22UHMK11.74016150
23PRKD31.67280516
24STK38L1.64102914
25PASK1.55730321
26MKNK21.52670910
27FRK1.51406555
28NUAK11.46657811
29ZAK1.44150230
30MKNK11.43111136
31CAMKK21.40877871
32TNIK1.40567230
33CDK191.40462915
34MAP2K41.37234303
35SIK31.37202512
36MAP3K121.37165451
37DAPK21.35824129
38PAK61.33604997
39PHKG21.31060945
40PHKG11.31060945
41TSSK61.29516091
42CDK51.27773483
43GRK11.26726465
44PAK31.25161398
45MAP3K21.24562153
46DYRK21.24492865
47SGK2231.22775359
48SGK4941.22775359
49SGK21.22137744
50BCKDK1.18124074
51NEK11.17151268
52PLK21.15042692
53NTRK11.13890871
54CAMKK11.11764918
55DYRK31.11108955
56PNCK1.09140435
57OXSR11.07543732
58AKT31.06900015
59CDC71.06366260
60BUB11.04385888
61DAPK10.97714433
62RPS6KA40.96802797
63DYRK1A0.96516741
64HIPK20.96491817
65STK160.96066315
66PRKCG0.94138729
67TTK0.87895685
68WNK40.87566057
69PRPF4B0.85141365
70PLK10.82714484
71CCNB10.82214042
72VRK10.81176218
73CAMK2A0.80359056
74PLK40.77814765
75CSNK1G20.76830047
76CAMK2B0.75599746
77KSR20.74962255
78PRKCH0.73267781
79PRKCE0.72730727
80BRSK10.72137629
81FGFR20.71183220
82PDGFRA0.71008370
83CDC42BPA0.70822916
84LIMK10.70470598
85SGK30.68087024
86BMPR1B0.67775747
87RET0.67651328
88BRSK20.67449643
89SGK10.66151995
90SCYL20.65305291
91GRK50.64311334
92PINK10.63982299
93FER0.62820158
94RPS6KA20.62000980
95BRD40.61865854
96CDK180.61503613
97STK390.61032890
98CDK140.60245806
99EPHA30.60119235
100EIF2AK30.59490723
101IRAK20.58142702
102CAMK2D0.57947953
103TIE10.57898773
104SIK20.56276260
105TYRO30.54340158
106ATR0.52897877
107ACVR1B0.51579236
108CDK150.51133690
109OBSCN0.50464866
110CSNK1D0.50225558
111PKN10.49113596
112WNK10.49081309
113CSNK1E0.48681661
114CSNK1A10.48122377
115BMPR20.47661095
116RPS6KA30.47057416
117PLK30.45993965
118GRK70.45533283
119MAP3K50.45050861
120STK380.44445749
121CAMK1G0.43678419
122NEK60.43524403
123ADRBK10.43504466
124ATM0.43083402
125EPHB20.42266749
126PRKCZ0.42197169
127MARK20.42110774
128NME10.41612017
129MAPK100.41467858
130TAF10.41243063
131MAP3K60.40874258
132PDK20.40696630
133PRKAA10.40674265
134CDK11A0.40191744
135CAMK10.40069161
136WEE10.40055307
137STK110.39894547
138PRKACA0.39787310
139RPS6KB10.38883313
140YES10.38714227
141STK30.38512454
142RPS6KA50.37954878
143CSNK1G30.37137561
144NEK20.35712705
145PRKG10.34239714
146AURKA0.34177690
147MAP3K10.32638910
148ADRBK20.32453038

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11821827
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.00130570
3Insulin secretion_Homo sapiens_hsa049112.92517563
4Synaptic vesicle cycle_Homo sapiens_hsa047212.89101953
5GABAergic synapse_Homo sapiens_hsa047272.52181891
6Circadian entrainment_Homo sapiens_hsa047132.51957840
7Amphetamine addiction_Homo sapiens_hsa050312.47051938
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34577587
9Dopaminergic synapse_Homo sapiens_hsa047282.25469938
10Morphine addiction_Homo sapiens_hsa050322.24136555
11Cocaine addiction_Homo sapiens_hsa050302.21616057
12Olfactory transduction_Homo sapiens_hsa047402.19255096
13Long-term potentiation_Homo sapiens_hsa047202.14483674
14Basal transcription factors_Homo sapiens_hsa030222.09309592
15Glutamatergic synapse_Homo sapiens_hsa047242.03168373
16Taste transduction_Homo sapiens_hsa047422.00342816
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87990838
18Serotonergic synapse_Homo sapiens_hsa047261.87571570
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86415107
20Cholinergic synapse_Homo sapiens_hsa047251.84367070
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81099946
22Type II diabetes mellitus_Homo sapiens_hsa049301.78509698
23Propanoate metabolism_Homo sapiens_hsa006401.75890699
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75657972
25Vibrio cholerae infection_Homo sapiens_hsa051101.70258013
26Fanconi anemia pathway_Homo sapiens_hsa034601.69522642
27Steroid biosynthesis_Homo sapiens_hsa001001.69032799
28Selenocompound metabolism_Homo sapiens_hsa004501.67302955
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65333816
30Renin secretion_Homo sapiens_hsa049241.63567234
31RNA polymerase_Homo sapiens_hsa030201.61230565
32Collecting duct acid secretion_Homo sapiens_hsa049661.58455689
33RNA degradation_Homo sapiens_hsa030181.53881665
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51068481
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48063443
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46663366
37Non-homologous end-joining_Homo sapiens_hsa034501.44424458
38Long-term depression_Homo sapiens_hsa047301.38177738
39Salivary secretion_Homo sapiens_hsa049701.36128831
40Mismatch repair_Homo sapiens_hsa034301.34373982
41Circadian rhythm_Homo sapiens_hsa047101.34363636
42Oxytocin signaling pathway_Homo sapiens_hsa049211.32128845
43Huntingtons disease_Homo sapiens_hsa050161.29537718
44Gastric acid secretion_Homo sapiens_hsa049711.27368531
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26989443
46Gap junction_Homo sapiens_hsa045401.26741208
47Fatty acid elongation_Homo sapiens_hsa000621.26200646
48Axon guidance_Homo sapiens_hsa043601.26109984
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25781155
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.25457949
51Calcium signaling pathway_Homo sapiens_hsa040201.21042380
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20746260
53Protein export_Homo sapiens_hsa030601.20074095
54Type I diabetes mellitus_Homo sapiens_hsa049401.18051799
55Proteasome_Homo sapiens_hsa030501.17944712
56Estrogen signaling pathway_Homo sapiens_hsa049151.16271853
57RNA transport_Homo sapiens_hsa030131.12824114
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12026193
59cAMP signaling pathway_Homo sapiens_hsa040241.11238963
60Homologous recombination_Homo sapiens_hsa034401.10775644
61Glucagon signaling pathway_Homo sapiens_hsa049221.06234139
62GnRH signaling pathway_Homo sapiens_hsa049121.05576499
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04586424
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04058297
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03218725
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02613059
67Base excision repair_Homo sapiens_hsa034101.01627851
68Alcoholism_Homo sapiens_hsa050340.99714009
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99493304
70Melanogenesis_Homo sapiens_hsa049160.97643256
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97246239
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96952782
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96437693
74Nitrogen metabolism_Homo sapiens_hsa009100.95647226
75Hippo signaling pathway_Homo sapiens_hsa043900.95010824
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93213823
77Cardiac muscle contraction_Homo sapiens_hsa042600.92820153
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89156372
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86954278
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86778607
81Thyroid hormone synthesis_Homo sapiens_hsa049180.86642771
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84762830
83Spliceosome_Homo sapiens_hsa030400.84559164
84ErbB signaling pathway_Homo sapiens_hsa040120.84545928
85Pyruvate metabolism_Homo sapiens_hsa006200.84247963
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83993904
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83665095
88Glioma_Homo sapiens_hsa052140.81791399
89Peroxisome_Homo sapiens_hsa041460.81410503
90Dilated cardiomyopathy_Homo sapiens_hsa054140.81375146
91Oocyte meiosis_Homo sapiens_hsa041140.81344137
92Phototransduction_Homo sapiens_hsa047440.80189953
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.80166217
94Ether lipid metabolism_Homo sapiens_hsa005650.79362124
95Pancreatic secretion_Homo sapiens_hsa049720.79312704
96Cell cycle_Homo sapiens_hsa041100.76484877
97Basal cell carcinoma_Homo sapiens_hsa052170.74903407
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73378122
99Endometrial cancer_Homo sapiens_hsa052130.72555580
100mRNA surveillance pathway_Homo sapiens_hsa030150.71120462
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70854407
102Nucleotide excision repair_Homo sapiens_hsa034200.70304665
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69572352
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69149384
105Regulation of autophagy_Homo sapiens_hsa041400.68819691
106Linoleic acid metabolism_Homo sapiens_hsa005910.67663348
107Purine metabolism_Homo sapiens_hsa002300.67088739
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66557720
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66461875
110Wnt signaling pathway_Homo sapiens_hsa043100.66276665
111Tryptophan metabolism_Homo sapiens_hsa003800.65749116
112Insulin signaling pathway_Homo sapiens_hsa049100.65146528
113N-Glycan biosynthesis_Homo sapiens_hsa005100.64924644
114beta-Alanine metabolism_Homo sapiens_hsa004100.64290945
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62285191
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62051324
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61222289
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61025553
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60999697
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.59401864
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58886962
122Alzheimers disease_Homo sapiens_hsa050100.55965979
123Metabolic pathways_Homo sapiens_hsa011000.55922170
124MAPK signaling pathway_Homo sapiens_hsa040100.54352565
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.53447028
126Choline metabolism in cancer_Homo sapiens_hsa052310.52453068
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52274948
128Hedgehog signaling pathway_Homo sapiens_hsa043400.52030115
129Pyrimidine metabolism_Homo sapiens_hsa002400.51917454
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50294071
131Colorectal cancer_Homo sapiens_hsa052100.49795155
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49527518
133Vitamin B6 metabolism_Homo sapiens_hsa007500.49347641
134Caffeine metabolism_Homo sapiens_hsa002320.49303594
135Tight junction_Homo sapiens_hsa045300.49260534
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49189277
137Oxidative phosphorylation_Homo sapiens_hsa001900.48976743
138Dorso-ventral axis formation_Homo sapiens_hsa043200.48382819
139Prion diseases_Homo sapiens_hsa050200.47993199
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47599061
141Sulfur metabolism_Homo sapiens_hsa009200.47156606
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47141764
143Butanoate metabolism_Homo sapiens_hsa006500.46468085
144mTOR signaling pathway_Homo sapiens_hsa041500.46372070
145Prolactin signaling pathway_Homo sapiens_hsa049170.45463181
146Arginine and proline metabolism_Homo sapiens_hsa003300.45406797
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45259726
148Renal cell carcinoma_Homo sapiens_hsa052110.45118624
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44873719
150Retinol metabolism_Homo sapiens_hsa008300.44654472
151Ras signaling pathway_Homo sapiens_hsa040140.42850130
152Parkinsons disease_Homo sapiens_hsa050120.41928418
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41912720
154Phospholipase D signaling pathway_Homo sapiens_hsa040720.40809219
155Inositol phosphate metabolism_Homo sapiens_hsa005620.39017406
156Ovarian steroidogenesis_Homo sapiens_hsa049130.36931393
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35395199
158AMPK signaling pathway_Homo sapiens_hsa041520.32287052

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