KLHL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)6.67110086
2regulation of meiosis (GO:0040020)5.98261312
3regulation of meiosis I (GO:0060631)5.67043086
4regulation of female gonad development (GO:2000194)4.94164890
5regulation of meiotic cell cycle (GO:0051445)4.86277905
6female gamete generation (GO:0007292)4.85956537
7negative regulation of meiosis (GO:0045835)4.62871537
8negative regulation of hormone biosynthetic process (GO:0032353)4.60825172
9negative regulation of hormone metabolic process (GO:0032351)4.60825172
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.48135650
11neural tube formation (GO:0001841)4.37275269
12protein K6-linked ubiquitination (GO:0085020)4.36507581
13mitotic metaphase plate congression (GO:0007080)4.33374722
14negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.33047564
15male meiosis (GO:0007140)4.30139901
16histone H2A monoubiquitination (GO:0035518)4.25727543
17pyrimidine nucleobase catabolic process (GO:0006208)4.24031901
18microtubule severing (GO:0051013)4.20882080
19regulation of exit from mitosis (GO:0007096)4.14261758
20regulation of histone H3-K27 methylation (GO:0061085)4.10342082
21mitotic chromosome condensation (GO:0007076)4.09196845
22glycerophospholipid catabolic process (GO:0046475)4.03230764
23centriole replication (GO:0007099)3.98646688
24DNA damage induced protein phosphorylation (GO:0006975)3.98211217
25histone H2A ubiquitination (GO:0033522)3.96041816
26oocyte maturation (GO:0001556)3.93172845
27nucleobase catabolic process (GO:0046113)3.89459225
28negative regulation of meiotic cell cycle (GO:0051447)3.83689622
29DNA methylation involved in gamete generation (GO:0043046)3.73771269
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64165163
31regulation of DNA endoreduplication (GO:0032875)3.61995041
32regulation of sister chromatid cohesion (GO:0007063)3.59836177
33positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.59179328
34DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.58022569
35positive regulation of meiosis (GO:0045836)3.54238291
36meiotic cell cycle (GO:0051321)3.52256297
37behavioral response to nicotine (GO:0035095)3.52146931
38DNA damage response, signal transduction resulting in transcription (GO:0042772)3.52071104
39positive regulation of megakaryocyte differentiation (GO:0045654)3.48051092
40metaphase plate congression (GO:0051310)3.45715610
41negative regulation of smooth muscle cell differentiation (GO:0051151)3.45516873
42type B pancreatic cell development (GO:0003323)3.43553378
43chaperone-mediated protein transport (GO:0072321)3.38697088
44maturation of 5.8S rRNA (GO:0000460)3.38560182
45synapsis (GO:0007129)3.37901008
46female gonad development (GO:0008585)3.37289782
47positive regulation of meiotic cell cycle (GO:0051446)3.35474841
48monoubiquitinated protein deubiquitination (GO:0035520)3.33339361
49regulation of transforming growth factor beta2 production (GO:0032909)3.32082785
50regulation of retinoic acid receptor signaling pathway (GO:0048385)3.21838935
51regulation of glucocorticoid metabolic process (GO:0031943)3.19753748
52protein K11-linked deubiquitination (GO:0035871)3.17819040
53regulation of corticosteroid hormone secretion (GO:2000846)3.16294368
54regulation of clathrin-mediated endocytosis (GO:2000369)3.15987162
55establishment of chromosome localization (GO:0051303)3.15493187
56negative regulation of circadian rhythm (GO:0042754)3.13456029
57nonmotile primary cilium assembly (GO:0035058)3.12366845
58microtubule anchoring (GO:0034453)3.09292408
59gene silencing by RNA (GO:0031047)3.09216390
60epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09149378
61regulation of hexokinase activity (GO:1903299)3.08354591
62regulation of glucokinase activity (GO:0033131)3.08354591
63interkinetic nuclear migration (GO:0022027)3.04396855
64notochord development (GO:0030903)3.04186682
65DNA double-strand break processing (GO:0000729)3.01459224
66snRNA transcription (GO:0009301)3.00570620
67response to pheromone (GO:0019236)2.99431626
68retinal ganglion cell axon guidance (GO:0031290)2.98811585
69righting reflex (GO:0060013)2.98476036
70L-fucose catabolic process (GO:0042355)2.97323058
71fucose catabolic process (GO:0019317)2.97323058
72L-fucose metabolic process (GO:0042354)2.97323058
73regulation of DNA methylation (GO:0044030)2.96600267
74mitotic sister chromatid segregation (GO:0000070)2.95679260
75microtubule nucleation (GO:0007020)2.94652505
76regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93591978
77regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93591978
78olfactory bulb development (GO:0021772)2.93225984
79centriole assembly (GO:0098534)2.92564162
80regulation of steroid hormone secretion (GO:2000831)2.92159128
81intraciliary transport (GO:0042073)2.88267495
82regulation of short-term neuronal synaptic plasticity (GO:0048172)2.87458445
83photoreceptor cell maintenance (GO:0045494)2.85828272
84attachment of spindle microtubules to kinetochore (GO:0008608)2.84711839
85base-excision repair, AP site formation (GO:0006285)2.84454200
86presynaptic membrane assembly (GO:0097105)2.83108664
87polyol catabolic process (GO:0046174)2.82312086
88positive regulation of sodium ion transmembrane transport (GO:1902307)2.81098266
89resolution of meiotic recombination intermediates (GO:0000712)2.80574557
90protein localization to cilium (GO:0061512)2.80562042
91heart field specification (GO:0003128)2.80063538
92secondary heart field specification (GO:0003139)2.80063538
93regulation of glucocorticoid secretion (GO:2000849)2.79618902
94regulation of cilium movement (GO:0003352)2.79098959
95positive regulation of mitochondrial fission (GO:0090141)2.78523206
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78356397
97positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.77211783
98cilium morphogenesis (GO:0060271)2.76465775
99reciprocal DNA recombination (GO:0035825)2.72173426
100reciprocal meiotic recombination (GO:0007131)2.72173426
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71556066
102cytoplasmic mRNA processing body assembly (GO:0033962)2.70813594
103histone mRNA catabolic process (GO:0071044)2.69207928
104preassembly of GPI anchor in ER membrane (GO:0016254)2.68445090
105mitotic sister chromatid cohesion (GO:0007064)2.67850581
106protein monoubiquitination (GO:0006513)2.67038702
107synaptic vesicle exocytosis (GO:0016079)2.66400433
108platelet dense granule organization (GO:0060155)2.65870805
109regulation of calcium ion-dependent exocytosis (GO:0017158)2.65613693
110meiotic chromosome segregation (GO:0045132)2.65246267
111cilium organization (GO:0044782)2.64991050
112respiratory chain complex IV assembly (GO:0008535)2.64255724
113regulation of steroid hormone biosynthetic process (GO:0090030)2.63878080
114regulation of acrosome reaction (GO:0060046)2.63426338
115hindbrain development (GO:0030902)2.63363343
116epithelial cilium movement (GO:0003351)2.63164915
117synaptonemal complex assembly (GO:0007130)2.62866149
118male meiosis I (GO:0007141)2.62408725
119cilium assembly (GO:0042384)2.61847175
120positive regulation of mitotic sister chromatid separation (GO:1901970)2.61405014
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61405014
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61405014
123protein autoubiquitination (GO:0051865)2.61270234
124mitochondrial respiratory chain complex I assembly (GO:0032981)2.61247291
125NADH dehydrogenase complex assembly (GO:0010257)2.61247291
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61247291
127synaptic vesicle endocytosis (GO:0048488)2.60152714
128replication fork processing (GO:0031297)2.59704843
129neuron cell-cell adhesion (GO:0007158)2.59511819
130DNA methylation (GO:0006306)2.57979811
131DNA alkylation (GO:0006305)2.57979811
132synaptonemal complex organization (GO:0070193)2.57772620
133protein K48-linked ubiquitination (GO:0070936)2.57529153
134protein polyglutamylation (GO:0018095)2.57477319
135sister chromatid cohesion (GO:0007062)2.57356082
136regulation of early endosome to late endosome transport (GO:2000641)2.57296257
137negative regulation of reproductive process (GO:2000242)2.57243124
138meiotic nuclear division (GO:0007126)2.55924721
139inositol phosphate catabolic process (GO:0071545)2.54889236
140single strand break repair (GO:0000012)2.52609753
141regulation of telomere maintenance via telomerase (GO:0032210)2.51980584
142phosphatidylglycerol biosynthetic process (GO:0006655)2.51953653
143meiosis I (GO:0007127)2.51677546
144layer formation in cerebral cortex (GO:0021819)2.51644808
145regulation of cell maturation (GO:1903429)2.51226846
146negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.50669786
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50298543
148protein localization to chromosome (GO:0034502)2.49528780
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49258660
150protein complex localization (GO:0031503)2.49197454
151positive regulation of neurological system process (GO:0031646)2.49002855
152Golgi to endosome transport (GO:0006895)2.48528691
153spinal cord motor neuron differentiation (GO:0021522)2.47532822
154positive regulation of protein targeting to membrane (GO:0090314)2.47299102
155negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46953678
156histone H2A acetylation (GO:0043968)2.46741650
157detection of light stimulus involved in sensory perception (GO:0050962)2.45774094
158detection of light stimulus involved in visual perception (GO:0050908)2.45774094
159cellular ketone body metabolic process (GO:0046950)2.45276496
160startle response (GO:0001964)2.43888817
161regulation of growth hormone secretion (GO:0060123)2.43797089
162positive regulation of growth hormone secretion (GO:0060124)2.42182335
163regulation of mitochondrial fission (GO:0090140)2.42037388
164rRNA catabolic process (GO:0016075)2.42026941
165negative regulation of DNA recombination (GO:0045910)2.41983453
166embryonic epithelial tube formation (GO:0001838)2.41749510
167dosage compensation (GO:0007549)2.40850883
168cornea development in camera-type eye (GO:0061303)2.39787891
169ubiquinone metabolic process (GO:0006743)2.39231841
170negative regulation of mast cell activation (GO:0033004)2.38660378
171recombinational repair (GO:0000725)2.38099027
172negative regulation of DNA-dependent DNA replication (GO:2000104)2.34625710
173double-strand break repair via homologous recombination (GO:0000724)2.34605812
174axoneme assembly (GO:0035082)2.34548275
175ubiquinone biosynthetic process (GO:0006744)2.32704167
176positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.32004287
177microtubule depolymerization (GO:0007019)2.30462912
178dentate gyrus development (GO:0021542)2.30065004
179inositol phosphate dephosphorylation (GO:0046855)2.29245146
180phosphorylated carbohydrate dephosphorylation (GO:0046838)2.29245146
181presynaptic membrane organization (GO:0097090)2.27717739
182anterograde synaptic vesicle transport (GO:0048490)2.26909543
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.26780668
184regulation of sarcomere organization (GO:0060297)2.26026475
185protein complex biogenesis (GO:0070271)2.24158521
186somite development (GO:0061053)2.23783805
187water-soluble vitamin biosynthetic process (GO:0042364)2.22938095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.45134673
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.99626155
3ZNF274_21170338_ChIP-Seq_K562_Hela2.54373597
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.53591964
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50246792
6GBX2_23144817_ChIP-Seq_PC3_Human2.45775796
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37634043
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36955868
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.32583727
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24359218
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19398026
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18993057
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.17308493
14KAP1_22055183_ChIP-Seq_ESCs_Mouse2.10521609
15RNF2_27304074_Chip-Seq_NSC_Mouse2.09490571
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04782376
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04728576
18ER_23166858_ChIP-Seq_MCF-7_Human2.04134069
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.02686025
20IGF1R_20145208_ChIP-Seq_DFB_Human2.01938670
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96780258
22FUS_26573619_Chip-Seq_HEK293_Human1.88806248
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.81555711
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80702309
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78780061
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78062509
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.73425319
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69823749
29AR_21572438_ChIP-Seq_LNCaP_Human1.69472802
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66801693
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65783992
32CBP_20019798_ChIP-Seq_JUKART_Human1.65371813
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65371813
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65013813
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64591965
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62516014
37ELK1_19687146_ChIP-ChIP_HELA_Human1.59080110
38TAF15_26573619_Chip-Seq_HEK293_Human1.57240057
39REST_21632747_ChIP-Seq_MESCs_Mouse1.55910011
40STAT3_23295773_ChIP-Seq_U87_Human1.55578508
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54882794
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.51868007
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51680118
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.49252695
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48546560
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47686697
47SMAD4_21799915_ChIP-Seq_A2780_Human1.47589436
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44942279
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44942279
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44517320
51LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43851138
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42667435
53* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41717024
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.38775372
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38365199
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37441873
57TP53_22573176_ChIP-Seq_HFKS_Human1.37160192
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36457740
59IRF1_19129219_ChIP-ChIP_H3396_Human1.36337159
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36124732
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.35519342
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.35267257
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34818930
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34765764
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32908107
66BCAT_22108803_ChIP-Seq_LS180_Human1.32832035
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32081606
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.31656122
69VDR_22108803_ChIP-Seq_LS180_Human1.31315336
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.30490102
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30046602
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29331685
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29085676
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28793082
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.28756966
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27895258
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23508397
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22861671
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22861671
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.22737626
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22616520
82P53_22387025_ChIP-Seq_ESCs_Mouse1.21276237
83VDR_23849224_ChIP-Seq_CD4+_Human1.20227134
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20215658
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20207817
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20190118
87* P300_19829295_ChIP-Seq_ESCs_Human1.19397579
88TCF4_22108803_ChIP-Seq_LS180_Human1.18860227
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.18535036
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.18497545
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18284287
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.18149162
93* REST_18959480_ChIP-ChIP_MESCs_Mouse1.18116366
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17787323
95* AR_25329375_ChIP-Seq_VCAP_Human1.17447030
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17161741
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.15583109
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15529460
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.15137044
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13958117
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13797853
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.13099574
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13080148
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.12748584
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12299017
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12225807
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11723799
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11604200
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11588037
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10896409
111* SOX2_21211035_ChIP-Seq_LN229_Gbm1.10812490
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10510721
113* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10145735
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09404108
115TCF4_23295773_ChIP-Seq_U87_Human1.08932874
116* CDX2_22108803_ChIP-Seq_LS180_Human1.08443934
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07113229
118TBL1_22424771_ChIP-Seq_293T_Human1.05850788
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.05626971
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05589600
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05398962
122* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05392385
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04479554
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04271256
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03647127
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03078784
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02922850
128KDM2B_26808549_Chip-Seq_REH_Human1.02855495
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02256217
130P300_18555785_Chip-Seq_ESCs_Mouse1.01301835
131FLI1_21867929_ChIP-Seq_TH2_Mouse1.00875534
132EWS_26573619_Chip-Seq_HEK293_Human1.00817918
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99768953
134* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98875365
135CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98237460
136JUN_21703547_ChIP-Seq_K562_Human0.97701176
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.96679100
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96147405
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95785075
140MYC_18940864_ChIP-ChIP_HL60_Human0.95276012
141SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93553436
142* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92569838
143* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91996865
144EP300_21415370_ChIP-Seq_HL-1_Mouse0.90872997
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.90815482
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90743879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.27744339
2MP0000569_abnormal_digit_pigmentation4.83127171
3MP0002653_abnormal_ependyma_morphology3.63938327
4MP0002102_abnormal_ear_morphology3.62697206
5MP0003718_maternal_effect3.51463395
6MP0005451_abnormal_body_composition3.29746671
7MP0004859_abnormal_synaptic_plasticity3.20618950
8MP0008057_abnormal_DNA_replication2.86385041
9MP0008877_abnormal_DNA_methylation2.71465029
10MP0004270_analgesia2.66204091
11MP0001529_abnormal_vocalization2.48099042
12MP0006292_abnormal_olfactory_placode2.40846868
13MP0003880_abnormal_central_pattern2.39512551
14MP0003787_abnormal_imprinting2.26259768
15MP0005646_abnormal_pituitary_gland2.18017264
16MP0000372_irregular_coat_pigmentation2.10453110
17MP0008058_abnormal_DNA_repair2.07411881
18MP0003635_abnormal_synaptic_transmissio2.02560266
19MP0005253_abnormal_eye_physiology2.02526747
20MP0005174_abnormal_tail_pigmentation1.84958253
21MP0004145_abnormal_muscle_electrophysio1.83238952
22MP0002734_abnormal_mechanical_nocicepti1.83229596
23MP0003123_paternal_imprinting1.82724283
24MP0003699_abnormal_female_reproductive1.80781876
25MP0000427_abnormal_hair_cycle1.73957037
26MP0004185_abnormal_adipocyte_glucose1.73208103
27MP0001929_abnormal_gametogenesis1.72512241
28MP0003195_calcinosis1.69760026
29MP0002063_abnormal_learning/memory/cond1.68470678
30MP0003693_abnormal_embryo_hatching1.67461522
31MP0002909_abnormal_adrenal_gland1.63806367
32MP0002234_abnormal_pharynx_morphology1.62417047
33MP0000579_abnormal_nail_morphology1.61756942
34MP0002160_abnormal_reproductive_system1.60515397
35MP0008995_early_reproductive_senescence1.58169047
36MP0002249_abnormal_larynx_morphology1.58151696
37MP0002822_catalepsy1.57976696
38MP0000653_abnormal_sex_gland1.56685709
39MP0001119_abnormal_female_reproductive1.56582564
40MP0005423_abnormal_somatic_nervous1.52861928
41MP0005395_other_phenotype1.49894989
42MP0002210_abnormal_sex_determination1.46478245
43MP0002009_preneoplasia1.46091040
44MP0003937_abnormal_limbs/digits/tail_de1.45324010
45MP0006276_abnormal_autonomic_nervous1.45207213
46MP0001188_hyperpigmentation1.43879094
47MP0006072_abnormal_retinal_apoptosis1.43028998
48MP0000383_abnormal_hair_follicle1.42975175
49MP0003011_delayed_dark_adaptation1.42309944
50MP0006035_abnormal_mitochondrial_morpho1.41882923
51MP0003121_genomic_imprinting1.41157255
52MP0005187_abnormal_penis_morphology1.40734872
53MP0004142_abnormal_muscle_tone1.40465349
54MP0002572_abnormal_emotion/affect_behav1.40337594
55MP0000015_abnormal_ear_pigmentation1.38728531
56MP0002095_abnormal_skin_pigmentation1.37995477
57MP0010386_abnormal_urinary_bladder1.37318669
58MP0001905_abnormal_dopamine_level1.33784136
59MP0001486_abnormal_startle_reflex1.31348673
60MP0001502_abnormal_circadian_rhythm1.30488742
61MP0002837_dystrophic_cardiac_calcinosis1.29732313
62MP0003111_abnormal_nucleus_morphology1.29278904
63MP0002184_abnormal_innervation1.28866203
64MP0002751_abnormal_autonomic_nervous1.27393375
65MP0000778_abnormal_nervous_system1.27140133
66MP0004147_increased_porphyrin_level1.26888486
67MP0009745_abnormal_behavioral_response1.26392939
68MP0003329_amyloid_beta_deposits1.26224607
69MP0005386_behavior/neurological_phenoty1.26179919
70MP0004924_abnormal_behavior1.26179919
71MP0002638_abnormal_pupillary_reflex1.24712581
72MP0000631_abnormal_neuroendocrine_gland1.24081329
73MP0002938_white_spotting1.22054081
74MP0003077_abnormal_cell_cycle1.20106269
75MP0002161_abnormal_fertility/fecundity1.19917774
76MP0001346_abnormal_lacrimal_gland1.19808767
77MP0002736_abnormal_nociception_after1.19652865
78MP0001968_abnormal_touch/_nociception1.19629674
79MP0010678_abnormal_skin_adnexa1.15755253
80MP0002272_abnormal_nervous_system1.15206477
81MP0002928_abnormal_bile_duct1.14890971
82MP0010094_abnormal_chromosome_stability1.14858495
83MP0001986_abnormal_taste_sensitivity1.13210894
84MP0002733_abnormal_thermal_nociception1.11888946
85MP0005389_reproductive_system_phenotype1.11361600
86MP0005075_abnormal_melanosome_morpholog1.11199349
87MP0001970_abnormal_pain_threshold1.10947588
88MP0000462_abnormal_digestive_system1.10437570
89MP0003315_abnormal_perineum_morphology1.09159580
90MP0001919_abnormal_reproductive_system1.08549739
91MP0003122_maternal_imprinting1.08542514
92MP0004742_abnormal_vestibular_system1.07466983
93MP0001145_abnormal_male_reproductive1.07230159
94MP0003221_abnormal_cardiomyocyte_apopto1.06462021
95MP0009046_muscle_twitch1.06229635
96MP0004957_abnormal_blastocyst_morpholog1.06200767
97MP0006036_abnormal_mitochondrial_physio1.06192645
98MP0003861_abnormal_nervous_system1.05985846
99MP0000955_abnormal_spinal_cord1.04744405
100MP0005310_abnormal_salivary_gland1.02614018
101MP0002064_seizures1.01192997
102MP0003698_abnormal_male_reproductive1.00735487
103MP0000647_abnormal_sebaceous_gland0.97687964
104MP0002085_abnormal_embryonic_tissue0.97624073
105MP0010234_abnormal_vibrissa_follicle0.96865655
106MP0004043_abnormal_pH_regulation0.96328940
107MP0002876_abnormal_thyroid_physiology0.95920580
108MP0002152_abnormal_brain_morphology0.95503798
109MP0002557_abnormal_social/conspecific_i0.95272741
110MP0002882_abnormal_neuron_morphology0.95169741
111MP0005391_vision/eye_phenotype0.94571370
112MP0000639_abnormal_adrenal_gland0.92868604
113MP0005195_abnormal_posterior_eye0.92865405
114MP0005408_hypopigmentation0.92596938
115MP0002084_abnormal_developmental_patter0.92305810
116MP0002752_abnormal_somatic_nervous0.90807448
117MP0002067_abnormal_sensory_capabilities0.90015103
118MP0002229_neurodegeneration0.89885603
119MP0003890_abnormal_embryonic-extraembry0.89364325
120MP0005645_abnormal_hypothalamus_physiol0.88611766
121MP0005379_endocrine/exocrine_gland_phen0.87414485
122MP0004036_abnormal_muscle_relaxation0.87216115
123MP0003755_abnormal_palate_morphology0.87020645
124MP0005084_abnormal_gallbladder_morpholo0.86888652
125MP0002332_abnormal_exercise_endurance0.86588342
126MP0001324_abnormal_eye_pigmentation0.85722122
127MP0001730_embryonic_growth_arrest0.85201931
128MP0009697_abnormal_copulation0.85171148
129MP0001984_abnormal_olfaction0.84533906
130MP0003879_abnormal_hair_cell0.83708299
131MP0001501_abnormal_sleep_pattern0.83669210
132MP0001440_abnormal_grooming_behavior0.83517484
133MP0004134_abnormal_chest_morphology0.82795499
134MP0000516_abnormal_urinary_system0.82581818
135MP0005367_renal/urinary_system_phenotyp0.82581818
136MP0002066_abnormal_motor_capabilities/c0.81348722
137MP0004811_abnormal_neuron_physiology0.80754727
138MP0001485_abnormal_pinna_reflex0.80677003
139MP0004233_abnormal_muscle_weight0.79586008
140MP0002163_abnormal_gland_morphology0.78056396
141MP0002233_abnormal_nose_morphology0.77699024
142MP0003938_abnormal_ear_development0.77190868
143MP0003632_abnormal_nervous_system0.76775326
144MP0005394_taste/olfaction_phenotype0.74044007
145MP0005499_abnormal_olfactory_system0.74044007
146MP0008789_abnormal_olfactory_epithelium0.73321382
147MP0002106_abnormal_muscle_physiology0.72926304
148MP0005551_abnormal_eye_electrophysiolog0.72257612
149MP0001697_abnormal_embryo_size0.71124203
150MP0008260_abnormal_autophagy0.70853593
151MP0004215_abnormal_myocardial_fiber0.70358313
152MP0002877_abnormal_melanocyte_morpholog0.66965292

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)6.06932461
2Papillary thyroid carcinoma (HP:0002895)4.57201330
3Focal motor seizures (HP:0011153)3.88344843
4Myokymia (HP:0002411)3.64274153
5Abnormality of the labia minora (HP:0012880)3.45143799
6Facial hemangioma (HP:0000329)3.37166293
7Shawl scrotum (HP:0000049)3.36403402
8Birth length less than 3rd percentile (HP:0003561)3.31028881
9Medial flaring of the eyebrow (HP:0010747)3.26819363
10Pancreatic cysts (HP:0001737)3.21581345
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.20103459
12Infertility (HP:0000789)3.19449561
13Hyperventilation (HP:0002883)2.98842765
14Hypothermia (HP:0002045)2.95524114
15Atonic seizures (HP:0010819)2.95423716
16Nephronophthisis (HP:0000090)2.92586661
17Adrenal hypoplasia (HP:0000835)2.90323749
18Abnormality of the renal cortex (HP:0011035)2.88447069
19True hermaphroditism (HP:0010459)2.87190043
20Abnormality of the fovea (HP:0000493)2.77691037
21Breast hypoplasia (HP:0003187)2.76297255
22Breast aplasia (HP:0100783)2.69239027
23Nephrogenic diabetes insipidus (HP:0009806)2.65196632
24Abnormal hair whorl (HP:0010721)2.64776554
25Aplasia/Hypoplasia of the breasts (HP:0010311)2.64267853
26Visual hallucinations (HP:0002367)2.63839349
27Arterial tortuosity (HP:0005116)2.61807580
28Renal cortical cysts (HP:0000803)2.61309531
29Cortical dysplasia (HP:0002539)2.55080288
30Volvulus (HP:0002580)2.54889801
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.54300157
32Hypoplasia of the fovea (HP:0007750)2.54300157
33Secondary amenorrhea (HP:0000869)2.50991529
34Abnormality of the renal medulla (HP:0100957)2.50486760
35Capillary hemangiomas (HP:0005306)2.50140418
36Flat capital femoral epiphysis (HP:0003370)2.49562085
37Patellar aplasia (HP:0006443)2.46658797
38Abnormality of chromosome stability (HP:0003220)2.45395022
39Premature ovarian failure (HP:0008209)2.45060750
40Oligodactyly (hands) (HP:0001180)2.44541375
41Thyroid carcinoma (HP:0002890)2.43927062
42Thyroid-stimulating hormone excess (HP:0002925)2.42300332
43Fetal akinesia sequence (HP:0001989)2.38050217
44Anterior segment dysgenesis (HP:0007700)2.35218513
45Primary amenorrhea (HP:0000786)2.33730232
46Chronic hepatic failure (HP:0100626)2.32262681
47Focal seizures (HP:0007359)2.28412879
48Aplasia/Hypoplasia of the patella (HP:0006498)2.26716167
49Insidious onset (HP:0003587)2.25993371
50Termporal pattern (HP:0011008)2.25993371
51Chromsome breakage (HP:0040012)2.25040177
52Agitation (HP:0000713)2.23631842
53Abnormality of macular pigmentation (HP:0008002)2.23201171
54Acute necrotizing encephalopathy (HP:0006965)2.21828276
55Progressive macrocephaly (HP:0004481)2.19996817
56Febrile seizures (HP:0002373)2.19040461
57Abnormality of the corticospinal tract (HP:0002492)2.18242249
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18011709
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17889205
60Vascular tortuosity (HP:0004948)2.13833520
61Constricted visual fields (HP:0001133)2.11871944
62Bony spicule pigmentary retinopathy (HP:0007737)2.10723895
63Lip pit (HP:0100267)2.10688354
64Neurofibrillary tangles (HP:0002185)2.10304144
65Insulin-resistant diabetes mellitus (HP:0000831)2.10179558
66Mutism (HP:0002300)2.09134208
67Urinary bladder sphincter dysfunction (HP:0002839)2.08587945
68Congenital stationary night blindness (HP:0007642)2.07129419
69Abnormal respiratory motile cilium physiology (HP:0012261)2.06715933
70Abnormality of chromosome segregation (HP:0002916)2.05073301
71Rhabdomyosarcoma (HP:0002859)2.04531415
72Absence seizures (HP:0002121)2.04509877
73Thyroiditis (HP:0100646)2.03608679
74Gonadotropin excess (HP:0000837)2.03316891
75Aplasia/Hypoplasia of the uvula (HP:0010293)2.02963033
76Acute encephalopathy (HP:0006846)2.02564189
77Fibular aplasia (HP:0002990)2.02288201
78Rib fusion (HP:0000902)2.00210520
79Oligodactyly (HP:0012165)2.00106464
80Genetic anticipation (HP:0003743)1.98283617
81Abnormality of lateral ventricle (HP:0030047)1.98259120
82Deep palmar crease (HP:0006191)1.97671626
83Chronic bronchitis (HP:0004469)1.96796807
84Anosmia (HP:0000458)1.96787889
85Postaxial foot polydactyly (HP:0001830)1.94963709
86Abnormal biliary tract physiology (HP:0012439)1.94051644
87Bile duct proliferation (HP:0001408)1.94051644
88Gait imbalance (HP:0002141)1.92852201
89Pancreatic fibrosis (HP:0100732)1.91572272
90Epileptic encephalopathy (HP:0200134)1.90874265
91Gaze-evoked nystagmus (HP:0000640)1.90742891
92Oculomotor apraxia (HP:0000657)1.90249661
93Abnormal drinking behavior (HP:0030082)1.89218828
94Polydipsia (HP:0001959)1.89218828
95Sandal gap (HP:0001852)1.89185740
96Cerebral inclusion bodies (HP:0100314)1.88350224
97Cystic hygroma (HP:0000476)1.87272330
98Progressive cerebellar ataxia (HP:0002073)1.86860297
99Dysmetria (HP:0001310)1.86491711
100Ketoacidosis (HP:0001993)1.85746952
101Hypogonadotrophic hypogonadism (HP:0000044)1.84995602
102Abolished electroretinogram (ERG) (HP:0000550)1.84578942
103Pachygyria (HP:0001302)1.83121051
104Protruding tongue (HP:0010808)1.82181715
105Aplasia/Hypoplasia of the sternum (HP:0006714)1.81873026
106Aplasia/Hypoplasia of the tongue (HP:0010295)1.81524513
107Excessive salivation (HP:0003781)1.80939633
108Drooling (HP:0002307)1.80939633
109Microglossia (HP:0000171)1.79896162
110Anencephaly (HP:0002323)1.79736881
111Nonprogressive disorder (HP:0003680)1.79034553
112Abnormal mitochondria in muscle tissue (HP:0008316)1.78478519
113Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78050813
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.78050813
115Abnormal rod and cone electroretinograms (HP:0008323)1.77924756
116Complete atrioventricular canal defect (HP:0001674)1.77832485
117Absent speech (HP:0001344)1.77625380
118Supernumerary spleens (HP:0009799)1.77557459
119Sclerocornea (HP:0000647)1.77055525
120Optic disc pallor (HP:0000543)1.76970063
121Postaxial hand polydactyly (HP:0001162)1.76185663
122Sloping forehead (HP:0000340)1.75824237
123Increased CSF lactate (HP:0002490)1.74808292
124Genital tract atresia (HP:0001827)1.74797313
125Narrow forehead (HP:0000341)1.74784803
126Fair hair (HP:0002286)1.74781486
127Neoplasm of the oral cavity (HP:0100649)1.74375316
128Molar tooth sign on MRI (HP:0002419)1.73478684
129Abnormality of midbrain morphology (HP:0002418)1.73478684
130Aplasia involving bones of the extremities (HP:0009825)1.73465600
131Aplasia involving bones of the upper limbs (HP:0009823)1.73465600
132Aplasia of the phalanges of the hand (HP:0009802)1.73465600
133Specific learning disability (HP:0001328)1.72702737
134Prominent nasal bridge (HP:0000426)1.72019092
135Polyphagia (HP:0002591)1.71826059
136Inability to walk (HP:0002540)1.71586925
137Medulloblastoma (HP:0002885)1.71340306
138Lissencephaly (HP:0001339)1.70927517
139Dialeptic seizures (HP:0011146)1.70908068
140Hyperalaninemia (HP:0003348)1.70125452
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70125452
142Abnormality of alanine metabolism (HP:0010916)1.70125452
143Tubulointerstitial nephritis (HP:0001970)1.70057692
144Abnormality of the fingertips (HP:0001211)1.69253336
145Absent septum pellucidum (HP:0001331)1.68950881
146Neoplasm of the adrenal cortex (HP:0100641)1.68754508
147Obstructive sleep apnea (HP:0002870)1.68421196
148Atelectasis (HP:0100750)1.68378186
149Neuroendocrine neoplasm (HP:0100634)1.68040517
150Mitochondrial inheritance (HP:0001427)1.67425854
151Posterior embryotoxon (HP:0000627)1.67142379
152Generalized tonic-clonic seizures (HP:0002069)1.67093038
153Progressive inability to walk (HP:0002505)1.66999517
154Astigmatism (HP:0000483)1.66648838
155Poor coordination (HP:0002370)1.65954330
156Chin dimple (HP:0010751)1.65479741
157Torticollis (HP:0000473)1.64674788
158Intestinal atresia (HP:0011100)1.63778714
159Neoplasm of the thyroid gland (HP:0100031)1.63708212
160Broad-based gait (HP:0002136)1.63228432
161Attenuation of retinal blood vessels (HP:0007843)1.63063199
162Male pseudohermaphroditism (HP:0000037)1.62804225
163Exotropia (HP:0000577)1.62727717
164Tubular atrophy (HP:0000092)1.61836091
165Abnormality of the line of Schwalbe (HP:0008048)1.61774845
166Methylmalonic acidemia (HP:0002912)1.61363498
167Midline defect of the nose (HP:0004122)1.61092728
168Congenital primary aphakia (HP:0007707)1.61031646
169Hepatic necrosis (HP:0002605)1.60377910
170Vaginal atresia (HP:0000148)1.59581670
171Aganglionic megacolon (HP:0002251)1.58437224
172Preaxial hand polydactyly (HP:0001177)1.58432334
173Abnormality of the phalanges of the hallux (HP:0010057)1.58240591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS24.38073499
2KSR24.10897710
3LATS14.09376503
4FRK3.84514337
5MAP3K93.82847366
6MAP3K63.79349771
7CASK3.69266679
8BMPR1B3.23719424
9ERBB42.85736267
10STK38L2.82920627
11MAP4K22.56312113
12MUSK2.42370186
13MAP3K42.34028993
14ERBB32.33561561
15WNK32.33436559
16TRIM282.30426218
17PRKD32.28322856
18PAK62.27353769
19MOS2.26015296
20RAF12.23709891
21TAOK12.20898110
22MAP3K132.19344530
23TAOK32.17729113
24KSR12.14393814
25EPHA32.02579501
26BCR1.96031906
27ARAF1.92348440
28CDK81.90066124
29EEF2K1.89082878
30BRAF1.84135558
31PLK41.82365442
32CAMKK21.78777869
33MAPK131.78178689
34DYRK21.73710572
35BMPR21.68388562
36MAP2K71.61308806
37NEK11.60498176
38CCNB11.57238765
39TTK1.44541637
40EPHA41.43172332
41SRPK11.40355719
42CDC71.40040831
43STK381.38841633
44ADRBK21.37335255
45TNIK1.36212252
46MAP2K41.34615945
47MARK11.32496895
48OBSCN1.32428183
49NUAK11.30474386
50NTRK21.29709291
51NLK1.26995664
52DYRK31.26616860
53TYRO31.25757102
54GRK11.23524708
55EIF2AK31.22672258
56MKNK21.21538409
57MAPKAPK31.19112552
58MELK1.17528137
59MST41.17218293
60AKT31.15619309
61STK31.15470170
62OXSR11.12953720
63NTRK31.12250240
64TLK11.06187698
65CHEK21.03196190
66CDK91.02810561
67BRSK20.99251653
68RET0.98814972
69DMPK0.97883597
70CDK190.95758093
71CAMK1G0.94710164
72YES10.88623500
73MAPKAPK50.88204894
74ABL20.86553716
75CSNK1G20.83697190
76PRKD20.83564862
77MKNK10.82765317
78MARK20.82608650
79PIK3CG0.82119147
80STK390.78596296
81NEK20.72321102
82PTK2B0.71059859
83ZAK0.70624911
84IRAK10.66700571
85CSNK1G10.65791524
86MAP3K20.65299395
87RPS6KB10.65049020
88PRKAA10.63897321
89WNK40.63653532
90CAMK2A0.63202082
91NTRK10.62105369
92PASK0.61749204
93RPS6KA40.61667586
94PLK10.60745492
95CSNK1G30.60142785
96SGK30.56894638
97PAK30.55754043
98MAP3K10.51687174
99HIPK20.51624265
100MAP3K50.51562444
101PLK20.51027175
102MINK10.50924590
103PRKCE0.50497331
104ERBB20.49571686
105STK160.49505455
106EIF2AK10.49505285
107MAP3K120.49505147
108CDK30.47814101
109ADRBK10.46733201
110PINK10.46127043
111PRKAA20.45752344
112FGR0.45724362
113SGK2230.45380726
114SGK4940.45380726
115ATR0.44449045
116MARK30.43832476
117CSNK1A1L0.43159850
118PNCK0.43117494
119PDK20.42506020
120TEC0.42497498
121CDK150.42359524
122STK110.42276087
123BRD40.41909897
124AURKA0.40390346
125PRKACB0.39948505
126CDK180.39818019
127SIK30.39495560
128MAP2K10.38818476
129PLK30.38441942
130CAMK1D0.38211163
131CDK50.37509052
132WNK10.37170742
133CAMK40.36604038
134PRKCG0.36043798
135MAPK100.35176756
136DYRK1A0.35030247
137GRK50.34729113
138PHKG10.34596931
139PHKG20.34596931
140RPS6KA50.34063284
141CDK11A0.33359155
142SGK20.32562710
143PIK3CA0.30944177
144CDK140.30146712
145CSNK1D0.27923917
146ACVR1B0.27381906
147CHEK10.25328859
148ATM0.24278670
149STK240.22734495
150BRSK10.22229216
151MAP3K80.21390228
152CDK10.19624991
153MAPK110.19404068
154RPS6KA30.18122808
155AURKB0.16104805
156SGK10.15794180
157CDK20.15171490
158GSK3B0.14209378
159CSNK1E0.12859966

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.43067580
2Protein export_Homo sapiens_hsa030603.18306457
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66815425
4Ovarian steroidogenesis_Homo sapiens_hsa049132.62963407
5Circadian rhythm_Homo sapiens_hsa047102.48145749
6Nicotine addiction_Homo sapiens_hsa050332.42896113
7Phototransduction_Homo sapiens_hsa047442.28272812
8Oocyte meiosis_Homo sapiens_hsa041142.25972982
9Basal transcription factors_Homo sapiens_hsa030222.17832968
10GnRH signaling pathway_Homo sapiens_hsa049122.16398222
11Cell cycle_Homo sapiens_hsa041102.15778256
12Propanoate metabolism_Homo sapiens_hsa006402.14038019
13Vitamin B6 metabolism_Homo sapiens_hsa007502.12266738
14RNA degradation_Homo sapiens_hsa030182.12188754
15Regulation of autophagy_Homo sapiens_hsa041402.09041796
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.08914969
17Butanoate metabolism_Homo sapiens_hsa006502.04810811
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.03466723
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98808385
20Nitrogen metabolism_Homo sapiens_hsa009101.94400119
21Long-term depression_Homo sapiens_hsa047301.90959093
22Dorso-ventral axis formation_Homo sapiens_hsa043201.90687899
23Long-term potentiation_Homo sapiens_hsa047201.86620097
24Glutamatergic synapse_Homo sapiens_hsa047241.80797597
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78146211
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74552998
27Homologous recombination_Homo sapiens_hsa034401.68081931
28Pancreatic cancer_Homo sapiens_hsa052121.67856259
29Oxidative phosphorylation_Homo sapiens_hsa001901.66612717
30Choline metabolism in cancer_Homo sapiens_hsa052311.60160113
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59428380
32Serotonergic synapse_Homo sapiens_hsa047261.56252083
33Synaptic vesicle cycle_Homo sapiens_hsa047211.55943088
34Parkinsons disease_Homo sapiens_hsa050121.55219689
35Colorectal cancer_Homo sapiens_hsa052101.54266626
36Renal cell carcinoma_Homo sapiens_hsa052111.52927892
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51727159
38Selenocompound metabolism_Homo sapiens_hsa004501.47109088
39TGF-beta signaling pathway_Homo sapiens_hsa043501.45894059
40Dopaminergic synapse_Homo sapiens_hsa047281.42521694
41VEGF signaling pathway_Homo sapiens_hsa043701.39371147
42Ether lipid metabolism_Homo sapiens_hsa005651.38556535
43GABAergic synapse_Homo sapiens_hsa047271.37794334
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37778609
45Steroid biosynthesis_Homo sapiens_hsa001001.37364833
46Amphetamine addiction_Homo sapiens_hsa050311.37138606
47Olfactory transduction_Homo sapiens_hsa047401.36828560
48mTOR signaling pathway_Homo sapiens_hsa041501.35000240
49Oxytocin signaling pathway_Homo sapiens_hsa049211.33523647
50Circadian entrainment_Homo sapiens_hsa047131.33050950
51Prolactin signaling pathway_Homo sapiens_hsa049171.30548483
52Cholinergic synapse_Homo sapiens_hsa047251.29416242
53Caffeine metabolism_Homo sapiens_hsa002321.28593678
54One carbon pool by folate_Homo sapiens_hsa006701.27298501
55Estrogen signaling pathway_Homo sapiens_hsa049151.26224272
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25847830
57Glioma_Homo sapiens_hsa052141.23075223
58ErbB signaling pathway_Homo sapiens_hsa040121.21955851
59Endometrial cancer_Homo sapiens_hsa052131.21919433
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20067796
61Linoleic acid metabolism_Homo sapiens_hsa005911.18669606
62Morphine addiction_Homo sapiens_hsa050321.17532124
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16287522
64Insulin secretion_Homo sapiens_hsa049111.14810694
65Cocaine addiction_Homo sapiens_hsa050301.09781157
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08435272
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06916464
68Mismatch repair_Homo sapiens_hsa034301.06820783
69cAMP signaling pathway_Homo sapiens_hsa040241.06273999
70Collecting duct acid secretion_Homo sapiens_hsa049661.05843011
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05475817
72Gap junction_Homo sapiens_hsa045401.04692769
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03616991
74RNA polymerase_Homo sapiens_hsa030201.03045779
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00883140
76Ras signaling pathway_Homo sapiens_hsa040141.00671500
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99569113
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99384816
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.98829229
80Salivary secretion_Homo sapiens_hsa049700.97697233
81Hippo signaling pathway_Homo sapiens_hsa043900.97480513
82Peroxisome_Homo sapiens_hsa041460.97322321
83Huntingtons disease_Homo sapiens_hsa050160.96615358
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96445504
85MAPK signaling pathway_Homo sapiens_hsa040100.96297015
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94303714
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94036314
88Taste transduction_Homo sapiens_hsa047420.93413975
89Non-small cell lung cancer_Homo sapiens_hsa052230.92901318
90MicroRNAs in cancer_Homo sapiens_hsa052060.89919522
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87589073
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.87513429
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83439941
94Type II diabetes mellitus_Homo sapiens_hsa049300.83210264
95Renin secretion_Homo sapiens_hsa049240.82667974
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80718704
97Melanogenesis_Homo sapiens_hsa049160.80098662
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79525009
99Axon guidance_Homo sapiens_hsa043600.79085421
100Fanconi anemia pathway_Homo sapiens_hsa034600.78979657
101Alzheimers disease_Homo sapiens_hsa050100.78372782
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.77993639
103Alcoholism_Homo sapiens_hsa050340.76503391
104Wnt signaling pathway_Homo sapiens_hsa043100.76067019
105Gastric acid secretion_Homo sapiens_hsa049710.75170166
106Fatty acid biosynthesis_Homo sapiens_hsa000610.74812450
107Inositol phosphate metabolism_Homo sapiens_hsa005620.74413217
108Pyrimidine metabolism_Homo sapiens_hsa002400.74365485
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74051938
110mRNA surveillance pathway_Homo sapiens_hsa030150.73866404
111RNA transport_Homo sapiens_hsa030130.72566170
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.71607061
113Purine metabolism_Homo sapiens_hsa002300.71100316
114Calcium signaling pathway_Homo sapiens_hsa040200.70970162
115FoxO signaling pathway_Homo sapiens_hsa040680.69611260
116Nucleotide excision repair_Homo sapiens_hsa034200.69117530
117Cardiac muscle contraction_Homo sapiens_hsa042600.68929981
118Melanoma_Homo sapiens_hsa052180.67104640
119Tryptophan metabolism_Homo sapiens_hsa003800.66147315
120Bladder cancer_Homo sapiens_hsa052190.66009979
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.63977957
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63785923
123Hedgehog signaling pathway_Homo sapiens_hsa043400.63684346
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63248044
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61993059
126Pancreatic secretion_Homo sapiens_hsa049720.61069968
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60860389
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58211317
129Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57715286
130Adherens junction_Homo sapiens_hsa045200.57196588
131beta-Alanine metabolism_Homo sapiens_hsa004100.56914821
132Dilated cardiomyopathy_Homo sapiens_hsa054140.53777680
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53636313
134Fatty acid metabolism_Homo sapiens_hsa012120.53606716
135Insulin signaling pathway_Homo sapiens_hsa049100.53148643
136Thyroid cancer_Homo sapiens_hsa052160.52329438
137Glucagon signaling pathway_Homo sapiens_hsa049220.50059572
138Tight junction_Homo sapiens_hsa045300.50010255
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48311183
140p53 signaling pathway_Homo sapiens_hsa041150.48216644
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47580115
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47419270
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45316946
144Renin-angiotensin system_Homo sapiens_hsa046140.44820589
145Rap1 signaling pathway_Homo sapiens_hsa040150.44397130
146Metabolic pathways_Homo sapiens_hsa011000.44114979
147Lysine degradation_Homo sapiens_hsa003100.42058862
148Spliceosome_Homo sapiens_hsa030400.36189040
149Fatty acid degradation_Homo sapiens_hsa000710.35902537
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35332894
151Sulfur metabolism_Homo sapiens_hsa009200.33406587
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31878866
153Fatty acid elongation_Homo sapiens_hsa000620.31770102
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28943655
155SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27559242
156Sphingolipid metabolism_Homo sapiens_hsa006000.27235098
157Arachidonic acid metabolism_Homo sapiens_hsa005900.27095626

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