KLHL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.14912727
2presynaptic membrane assembly (GO:0097105)5.34602063
3nucleobase catabolic process (GO:0046113)4.96086897
4negative regulation of dendrite morphogenesis (GO:0050774)4.95787745
5regulation of sarcomere organization (GO:0060297)4.81440458
6presynaptic membrane organization (GO:0097090)4.63888477
7neuron cell-cell adhesion (GO:0007158)4.59069068
8negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.58825873
9glomerulus development (GO:0032835)4.14154716
10cell differentiation involved in metanephros development (GO:0072202)4.10935328
11negative regulation of glycogen biosynthetic process (GO:0045719)4.05011701
12negative regulation of striated muscle cell apoptotic process (GO:0010664)4.04519292
13heart contraction (GO:0060047)4.03988994
14heart process (GO:0003015)4.03988994
15postsynaptic membrane organization (GO:0001941)3.93181697
16axonal fasciculation (GO:0007413)3.80318456
17neuron recognition (GO:0008038)3.71144254
18metanephric mesenchyme development (GO:0072075)3.64729550
19central nervous system projection neuron axonogenesis (GO:0021952)3.64658400
20negative regulation of dendrite development (GO:2000171)3.58994970
21cullin deneddylation (GO:0010388)3.58825541
22intraciliary transport (GO:0042073)3.53083971
23calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.52259880
24membrane assembly (GO:0071709)3.51094896
25auditory behavior (GO:0031223)3.50487325
26ribonucleoprotein complex disassembly (GO:0032988)3.47998743
27negative regulation of glycogen metabolic process (GO:0070874)3.47426419
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47211558
29kidney mesenchyme development (GO:0072074)3.35771692
30limb bud formation (GO:0060174)3.34725695
31ganglion development (GO:0061548)3.34411128
32forebrain neuron differentiation (GO:0021879)3.34006403
33protein deneddylation (GO:0000338)3.33987071
34atrial septum morphogenesis (GO:0060413)3.33417281
35gamma-aminobutyric acid transport (GO:0015812)3.31836703
36ER overload response (GO:0006983)3.29137316
37retinal ganglion cell axon guidance (GO:0031290)3.27083065
38inositol phosphate catabolic process (GO:0071545)3.26843572
39synapse assembly (GO:0007416)3.26297502
40mesenchymal cell differentiation involved in kidney development (GO:0072161)3.25352588
41mesenchymal cell differentiation involved in renal system development (GO:2001012)3.25352588
42positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.23936067
43negative regulation of homotypic cell-cell adhesion (GO:0034111)3.22552446
44negative regulation of protein localization to cell surface (GO:2000009)3.21968683
45dendrite morphogenesis (GO:0048813)3.20275490
46positive regulation of synapse assembly (GO:0051965)3.17722655
47cardiac myofibril assembly (GO:0055003)3.17204249
48sequestering of extracellular ligand from receptor (GO:0035581)3.15034465
49central nervous system neuron axonogenesis (GO:0021955)3.13561106
50vocalization behavior (GO:0071625)3.13390992
51dendritic spine morphogenesis (GO:0060997)3.12899398
52regulation of relaxation of muscle (GO:1901077)3.10458245
53olfactory bulb development (GO:0021772)3.08221323
54myoblast migration (GO:0051451)3.07869977
55negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.06633691
56positive regulation of myoblast differentiation (GO:0045663)3.05607466
57cerebral cortex cell migration (GO:0021795)3.04577544
58actin-mediated cell contraction (GO:0070252)3.02388882
59uterus development (GO:0060065)2.99954837
60kidney morphogenesis (GO:0060993)2.98330082
61positive regulation of mitochondrial fission (GO:0090141)2.97580720
62negative chemotaxis (GO:0050919)2.95272476
63mechanosensory behavior (GO:0007638)2.94423221
64epithelial cell differentiation involved in kidney development (GO:0035850)2.92760388
65somite development (GO:0061053)2.92626705
66protein localization to microtubule (GO:0035372)2.92540231
67positive regulation of male gonad development (GO:2000020)2.91482177
68appendage development (GO:0048736)2.91206675
69limb development (GO:0060173)2.91206675
70regulation of male gonad development (GO:2000018)2.91078619
71lung secretory cell differentiation (GO:0061140)2.90654417
72actin-myosin filament sliding (GO:0033275)2.90161787
73muscle filament sliding (GO:0030049)2.90161787
74mesenchyme morphogenesis (GO:0072132)2.87306479
75outflow tract septum morphogenesis (GO:0003148)2.86147985
76regulation of action potential (GO:0098900)2.85789607
77neural crest cell development (GO:0014032)2.85727032
78plasma membrane repair (GO:0001778)2.84235187
79neurotransmitter-gated ion channel clustering (GO:0072578)2.83863835
80nonmotile primary cilium assembly (GO:0035058)2.83668979
81cell differentiation involved in kidney development (GO:0061005)2.82578220
82cardiac muscle hypertrophy (GO:0003300)2.82307941
83extracellular regulation of signal transduction (GO:1900115)2.81422862
84extracellular negative regulation of signal transduction (GO:1900116)2.81422862
85negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.81416201
86regulation of cardiac muscle cell apoptotic process (GO:0010665)2.80890147
87nephron epithelium morphogenesis (GO:0072088)2.80698508
88nephron tubule morphogenesis (GO:0072078)2.80698508
89sympathetic nervous system development (GO:0048485)2.79290581
90cell proliferation involved in kidney development (GO:0072111)2.79276335
91negative regulation of mast cell activation (GO:0033004)2.78438693
92organelle disassembly (GO:1903008)2.78146483
93protein localization to synapse (GO:0035418)2.78024823
94regulation of synapse assembly (GO:0051963)2.78012572
95negative regulation of oligodendrocyte differentiation (GO:0048715)2.77969858
96daunorubicin metabolic process (GO:0044597)2.76617272
97polyketide metabolic process (GO:0030638)2.76617272
98doxorubicin metabolic process (GO:0044598)2.76617272
99regulation of smooth muscle cell differentiation (GO:0051150)2.75279461
100neural tube formation (GO:0001841)2.72239830
101definitive hemopoiesis (GO:0060216)2.71152316
102myofibril assembly (GO:0030239)2.70824716
103signal peptide processing (GO:0006465)2.70500688
104DNA double-strand break processing (GO:0000729)2.70331044
105protein localization to microtubule cytoskeleton (GO:0072698)2.69574476
106hippocampus development (GO:0021766)2.69397864
1072-deoxyribonucleotide biosynthetic process (GO:0009265)2.67947983
108deoxyribose phosphate biosynthetic process (GO:0046385)2.67947983
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67344025
110cardiac right ventricle morphogenesis (GO:0003215)2.67060058
111positive regulation of cardiac muscle tissue development (GO:0055025)2.67042506
112mesenchymal cell differentiation (GO:0048762)2.66448011
113regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.65651543
114muscle hypertrophy (GO:0014896)2.65458823
115cytochrome complex assembly (GO:0017004)2.65265529
116negative regulation of muscle hypertrophy (GO:0014741)2.64387707
117cardiac muscle tissue morphogenesis (GO:0055008)2.63161811
118myelin assembly (GO:0032288)2.61872384
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61540459
120heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.61121641
121viral protein processing (GO:0019082)2.60669992
122inner ear receptor cell development (GO:0060119)2.60469940
123establishment of mitochondrion localization (GO:0051654)2.59914357
124striated muscle hypertrophy (GO:0014897)2.59827653
125positive regulation of stem cell differentiation (GO:2000738)2.59796933
126reflex (GO:0060004)2.59397767
127negative regulation of cardiac muscle hypertrophy (GO:0010614)2.58957896
128regulation of glycogen (starch) synthase activity (GO:2000465)2.58917059
129regulation of striated muscle cell apoptotic process (GO:0010662)2.58222272
130facial nerve structural organization (GO:0021612)2.58148044
131regulation of oligodendrocyte differentiation (GO:0048713)2.57881989
132nucleus localization (GO:0051647)2.57344257
133embryonic skeletal joint morphogenesis (GO:0060272)2.57319277
134positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57032428
135startle response (GO:0001964)2.56837145
136misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.56709101
137mesenchymal cell development (GO:0014031)2.56392566
138glycosphingolipid biosynthetic process (GO:0006688)2.55998581
139histamine secretion (GO:0001821)2.55924930
140negative regulation of stem cell proliferation (GO:2000647)2.55909629
141cerebral cortex radially oriented cell migration (GO:0021799)2.55637739
142cell proliferation involved in metanephros development (GO:0072203)2.54600892
143synapse organization (GO:0050808)2.54020952
144endocardial cushion morphogenesis (GO:0003203)2.53854118
145renal tubule morphogenesis (GO:0061333)2.53486239
146positive regulation of amino acid transport (GO:0051957)2.53301515
147regulation of myoblast differentiation (GO:0045661)2.53096867
148metanephros development (GO:0001656)2.53030093
149protein complex biogenesis (GO:0070271)2.52792966
150regulation of cardiac muscle hypertrophy (GO:0010611)2.52475012
151regulation of non-canonical Wnt signaling pathway (GO:2000050)2.51158020
152embryonic digit morphogenesis (GO:0042733)2.50641114
153mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.50563114
154positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.50563114
155regulation of pigment cell differentiation (GO:0050932)2.49952095
156response to BMP (GO:0071772)2.49682362
157cellular response to BMP stimulus (GO:0071773)2.49682362
158lung vasculature development (GO:0060426)2.48836907
159negative regulation of neurotransmitter transport (GO:0051589)2.48642077
160axon extension (GO:0048675)2.48415515
161head development (GO:0060322)2.47204614
162negative regulation of potassium ion transmembrane transport (GO:1901380)2.47116538
163protein localization to cytoskeleton (GO:0044380)2.46589911
164homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.46335916
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.45568502
166neuron migration (GO:0001764)2.44536491
167positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.43967566
168cilium morphogenesis (GO:0060271)2.43553210
169protein localization to cilium (GO:0061512)2.42697972
170regulation of development, heterochronic (GO:0040034)2.41918509
171neuron fate determination (GO:0048664)2.40781245
172regulation of synaptic transmission, glutamatergic (GO:0051966)2.39980573
173negative regulation of axon guidance (GO:1902668)2.39680559
174hindbrain development (GO:0030902)2.39403331
175neuronal action potential (GO:0019228)2.37440960
176negative regulation of neurotransmitter secretion (GO:0046929)2.36458709
177negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36130871
178negative regulation of nitric-oxide synthase activity (GO:0051001)2.35318513
179response to auditory stimulus (GO:0010996)2.32261520
180ionotropic glutamate receptor signaling pathway (GO:0035235)2.31664837
181regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.31374920
182regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31067777
183cilium assembly (GO:0042384)2.29765992
184establishment of protein localization to Golgi (GO:0072600)2.29372419
185nerve growth factor signaling pathway (GO:0038180)2.29146850
186axonogenesis (GO:0007409)2.29007867
187regulation of axon guidance (GO:1902667)2.28925125
188regulation of membrane repolarization (GO:0060306)2.28678491
189epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27343718
190cilium organization (GO:0044782)2.26216957
191regulation of collateral sprouting (GO:0048670)2.26013113
192glial cell proliferation (GO:0014009)2.25631372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.18982467
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.97597354
3GBX2_23144817_ChIP-Seq_PC3_Human3.15339517
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.98371429
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.97877158
6ZNF274_21170338_ChIP-Seq_K562_Hela2.79191209
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.60557249
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49503803
9IGF1R_20145208_ChIP-Seq_DFB_Human2.35995961
10FUS_26573619_Chip-Seq_HEK293_Human2.35213942
11EWS_26573619_Chip-Seq_HEK293_Human2.29440313
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23046808
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.18099033
14P300_19829295_ChIP-Seq_ESCs_Human2.16497986
15EZH2_22144423_ChIP-Seq_EOC_Human2.04046707
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94909926
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87112352
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.85958525
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.85517766
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83313839
21TOP2B_26459242_ChIP-Seq_MCF-7_Human1.83176592
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82884407
23TAF15_26573619_Chip-Seq_HEK293_Human1.80630872
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78727681
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77379104
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73562226
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70996012
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70807387
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.70452827
30SMAD4_21799915_ChIP-Seq_A2780_Human1.69960018
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69685470
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.68692021
33* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65997997
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64839185
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.64342307
36RNF2_27304074_Chip-Seq_NSC_Mouse1.63763689
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62850167
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.61784665
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.60272532
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59352697
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54897913
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.54593625
43* ELK1_19687146_ChIP-ChIP_HELA_Human1.54494490
44TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.52286241
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52201215
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51710174
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48302825
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48263795
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47204342
50CBP_20019798_ChIP-Seq_JUKART_Human1.47204342
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45379285
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45379285
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44360640
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44304184
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.43255620
56E2F1_18555785_Chip-Seq_ESCs_Mouse1.42235610
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42125138
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41780407
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41673474
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40281026
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39215515
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38446443
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38446443
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.37589457
65P53_22387025_ChIP-Seq_ESCs_Mouse1.37193874
66TP53_18474530_ChIP-ChIP_U2OS_Human1.34958478
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34004851
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.33300111
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29754273
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.29079101
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28987791
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28978109
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28033469
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.27416031
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26288287
76ER_23166858_ChIP-Seq_MCF-7_Human1.25522119
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24911539
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23463234
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23420174
80JUN_21703547_ChIP-Seq_K562_Human1.22816320
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.22308080
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22041405
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21506420
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.21249440
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20863621
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20791067
87SOX9_26525672_Chip-Seq_HEART_Mouse1.20290579
88VDR_22108803_ChIP-Seq_LS180_Human1.19030811
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.18966727
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18884662
91GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18845857
92SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18237132
93IRF1_19129219_ChIP-ChIP_H3396_Human1.17377803
94REST_21632747_ChIP-Seq_MESCs_Mouse1.17101499
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15979590
96AR_25329375_ChIP-Seq_VCAP_Human1.15959269
97KDM2B_26808549_Chip-Seq_REH_Human1.15714629
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.15668480
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14894896
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14578752
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.13712927
102STAT3_23295773_ChIP-Seq_U87_Human1.13080949
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.11977086
104BCAT_22108803_ChIP-Seq_LS180_Human1.11916494
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11488463
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11371058
107SOX2_18555785_Chip-Seq_ESCs_Mouse1.11333241
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09272174
109P300_18555785_Chip-Seq_ESCs_Mouse1.09177538
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.09081094
111* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08611836
112* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08559636
113NMYC_18555785_Chip-Seq_ESCs_Mouse1.08516424
114CJUN_26792858_Chip-Seq_BT549_Human1.08313968
115JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08223556
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08137662
117GF1B_26923725_Chip-Seq_HPCs_Mouse1.07277440
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06816125
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06021265
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05526631
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05054176
122KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04864456
123RUNX2_22187159_ChIP-Seq_PCA_Human1.04504058
124TCF4_22108803_ChIP-Seq_LS180_Human1.04284217
125TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04167004
126TCF4_23295773_ChIP-Seq_U87_Human1.04089587

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.24756186
2MP0002102_abnormal_ear_morphology3.56920775
3MP0003121_genomic_imprinting3.43640668
4MP0003787_abnormal_imprinting3.42673657
5MP0009697_abnormal_copulation3.17554737
6MP0003123_paternal_imprinting2.91662845
7MP0005187_abnormal_penis_morphology2.66890821
8MP0004270_analgesia2.63673755
9MP0000778_abnormal_nervous_system2.59891721
10MP0003880_abnormal_central_pattern2.57796041
11MP0005171_absent_coat_pigmentation2.51233169
12MP0005503_abnormal_tendon_morphology2.40824296
13MP0000015_abnormal_ear_pigmentation2.40473436
14MP0005408_hypopigmentation2.33545498
15MP0000372_irregular_coat_pigmentation2.30642309
16MP0003385_abnormal_body_wall2.21157698
17MP0002009_preneoplasia2.21066864
18MP0001188_hyperpigmentation2.18758393
19MP0003942_abnormal_urinary_system2.05479587
20MP0002938_white_spotting1.96366397
21MP0001986_abnormal_taste_sensitivity1.94128824
22MP0009250_abnormal_appendicular_skeleto1.92041735
23MP0000566_synostosis1.91448982
24MP0003943_abnormal_hepatobiliary_system1.90829925
25MP0001177_atelectasis1.84040450
26MP0001879_abnormal_lymphatic_vessel1.83175797
27MP0005367_renal/urinary_system_phenotyp1.81066917
28MP0000516_abnormal_urinary_system1.81066917
29MP0004782_abnormal_surfactant_physiolog1.77640395
30MP0004859_abnormal_synaptic_plasticity1.75089808
31MP0006054_spinal_hemorrhage1.74867177
32MP0005623_abnormal_meninges_morphology1.72917134
33MP0002234_abnormal_pharynx_morphology1.72600100
34MP0001529_abnormal_vocalization1.68597800
35MP0008438_abnormal_cutaneous_collagen1.67854685
36MP0000749_muscle_degeneration1.66798942
37MP0003950_abnormal_plasma_membrane1.65117411
38MP0004133_heterotaxia1.62228279
39MP0002822_catalepsy1.61790125
40MP0000049_abnormal_middle_ear1.60860259
41MP0003115_abnormal_respiratory_system1.57670063
42MP0005646_abnormal_pituitary_gland1.57610021
43MP0006072_abnormal_retinal_apoptosis1.57352036
44MP0000569_abnormal_digit_pigmentation1.54325897
45MP0002163_abnormal_gland_morphology1.52492508
46MP0002282_abnormal_trachea_morphology1.49867498
47MP0009053_abnormal_anal_canal1.49052378
48MP0005248_abnormal_Harderian_gland1.48841063
49MP0002184_abnormal_innervation1.45755072
50MP0001299_abnormal_eye_distance/1.42020982
51MP0002734_abnormal_mechanical_nocicepti1.41929380
52MP0003635_abnormal_synaptic_transmissio1.39324176
53MP0000955_abnormal_spinal_cord1.39048926
54MP0008789_abnormal_olfactory_epithelium1.36735467
55MP0002972_abnormal_cardiac_muscle1.35044156
56MP0002751_abnormal_autonomic_nervous1.34656523
57MP0003941_abnormal_skin_development1.34467447
58MP0010030_abnormal_orbit_morphology1.29921321
59MP0002877_abnormal_melanocyte_morpholog1.29850567
60MP0009384_cardiac_valve_regurgitation1.29633261
61MP0005084_abnormal_gallbladder_morpholo1.29402066
62MP0008007_abnormal_cellular_replicative1.29227082
63MP0002177_abnormal_outer_ear1.28994345
64MP0002638_abnormal_pupillary_reflex1.28823301
65MP0003279_aneurysm1.28406500
66MP0009046_muscle_twitch1.27972963
67MP0000013_abnormal_adipose_tissue1.26390135
68MP0003315_abnormal_perineum_morphology1.26377984
69MP0001486_abnormal_startle_reflex1.24688045
70MP0002063_abnormal_learning/memory/cond1.23999490
71MP0002876_abnormal_thyroid_physiology1.23802183
72MP0000534_abnormal_ureter_morphology1.22439672
73MP0003938_abnormal_ear_development1.21560868
74MP0004084_abnormal_cardiac_muscle1.21537387
75MP0002160_abnormal_reproductive_system1.20521255
76MP0000537_abnormal_urethra_morphology1.20018642
77MP0005253_abnormal_eye_physiology1.19567005
78MP0008877_abnormal_DNA_methylation1.19065940
79MP0004134_abnormal_chest_morphology1.18613731
80MP0001919_abnormal_reproductive_system1.17978126
81MP0002095_abnormal_skin_pigmentation1.16657468
82MP0004142_abnormal_muscle_tone1.16522724
83MP0000751_myopathy1.16100460
84MP0004811_abnormal_neuron_physiology1.15310714
85MP0004924_abnormal_behavior1.14952449
86MP0005386_behavior/neurological_phenoty1.14952449
87MP0004272_abnormal_basement_membrane1.14605988
88MP0003755_abnormal_palate_morphology1.14605876
89MP0002557_abnormal_social/conspecific_i1.14172619
90MP0000647_abnormal_sebaceous_gland1.13338616
91MP0002272_abnormal_nervous_system1.13212767
92MP0000427_abnormal_hair_cycle1.12957673
93MP0002109_abnormal_limb_morphology1.12775876
94MP0006138_congestive_heart_failure1.12543822
95MP0003937_abnormal_limbs/digits/tail_de1.12393913
96MP0002572_abnormal_emotion/affect_behav1.12245911
97MP0006292_abnormal_olfactory_placode1.11988112
98MP0001984_abnormal_olfaction1.11617402
99MP0005645_abnormal_hypothalamus_physiol1.11112143
100MP0003221_abnormal_cardiomyocyte_apopto1.11030067
101MP0002735_abnormal_chemical_nociception1.10892714
102MP0009745_abnormal_behavioral_response1.10203230
103MP0000767_abnormal_smooth_muscle1.09500229
104MP0010386_abnormal_urinary_bladder1.09168485
105MP0001968_abnormal_touch/_nociception1.08684007
106MP0002233_abnormal_nose_morphology1.06084589
107MP0002882_abnormal_neuron_morphology1.05679897
108MP0003567_abnormal_fetal_cardiomyocyte1.04211557
109MP0004885_abnormal_endolymph1.03501177
110MP0005499_abnormal_olfactory_system1.03113476
111MP0005394_taste/olfaction_phenotype1.03113476
112MP0005389_reproductive_system_phenotype1.02604922
113MP0003861_abnormal_nervous_system1.01532489
114MP0001293_anophthalmia1.01343063
115MP0002736_abnormal_nociception_after1.01314764
116MP0002752_abnormal_somatic_nervous1.01060558
117MP0002928_abnormal_bile_duct1.00055104
118MP0002909_abnormal_adrenal_gland0.99969287
119MP0000026_abnormal_inner_ear0.99758008
120MP0005423_abnormal_somatic_nervous0.99343064
121MP0002133_abnormal_respiratory_system0.98250799
122MP0005388_respiratory_system_phenotype0.98250799
123MP0002067_abnormal_sensory_capabilities0.97358130
124MP0010368_abnormal_lymphatic_system0.95954542
125MP0002152_abnormal_brain_morphology0.95500435
126MP0006276_abnormal_autonomic_nervous0.95166031
127MP0005391_vision/eye_phenotype0.93817855
128MP0009780_abnormal_chondrocyte_physiolo0.91191644
129MP0003119_abnormal_digestive_system0.90778518
130MP0002249_abnormal_larynx_morphology0.89931450
131MP0005508_abnormal_skeleton_morphology0.89502525
132MP0000681_abnormal_thyroid_gland0.89197680
133MP0002132_abnormal_respiratory_system0.88466773
134MP0004085_abnormal_heartbeat0.88461544
135MP0001119_abnormal_female_reproductive0.88237752
136MP0000163_abnormal_cartilage_morphology0.88228076
137MP0002115_abnormal_skeleton_extremities0.87144494
138MP0003935_abnormal_craniofacial_develop0.85285793
139MP0001270_distended_abdomen0.85211680
140MP0002697_abnormal_eye_size0.85055726
141MP0003283_abnormal_digestive_organ0.84852071
142MP0005620_abnormal_muscle_contractility0.84749472
143MP0000428_abnormal_craniofacial_morphol0.84680750
144MP0002081_perinatal_lethality0.84654779
145MP0004147_increased_porphyrin_level0.83469108
146MP0000678_abnormal_parathyroid_gland0.82747543
147MP0000631_abnormal_neuroendocrine_gland0.82350596
148MP0002064_seizures0.82291018
149MP0003890_abnormal_embryonic-extraembry0.81754220
150MP0004484_altered_response_of0.81151414
151MP0002116_abnormal_craniofacial_bone0.79884657
152MP0001286_abnormal_eye_development0.79651000
153MP0001186_pigmentation_phenotype0.79093415
154MP0003828_pulmonary_edema0.78924037
155MP0008058_abnormal_DNA_repair0.78507061
156MP0000538_abnormal_urinary_bladder0.78401489
157MP0004215_abnormal_myocardial_fiber0.77155764
158MP0005551_abnormal_eye_electrophysiolog0.76820311
159MP0001485_abnormal_pinna_reflex0.76595749

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.04212566
2Abnormality of incisor morphology (HP:0011063)4.08189103
3Abnormal hair whorl (HP:0010721)4.06664977
4Spinal cord lesions (HP:0100561)3.89604974
5Syringomyelia (HP:0003396)3.89604974
6Drooling (HP:0002307)3.88212830
7Hypothermia (HP:0002045)3.80392860
8Diastasis recti (HP:0001540)3.68799771
9Hyperventilation (HP:0002883)3.61861643
10Excessive salivation (HP:0003781)3.57878415
11Papillary thyroid carcinoma (HP:0002895)3.57036876
12Asymmetry of the thorax (HP:0001555)3.49489704
13Abnormal pancreas size (HP:0012094)3.46487907
14Neoplasm of the adrenal gland (HP:0100631)3.41038100
15Hypoplastic left heart (HP:0004383)3.17920579
16Thyroid carcinoma (HP:0002890)3.17358603
17Calf muscle hypertrophy (HP:0008981)3.13905780
18Cortical dysplasia (HP:0002539)3.07660543
19Neoplasm of the adrenal cortex (HP:0100641)3.04162171
20True hermaphroditism (HP:0010459)3.01565191
21Embryonal renal neoplasm (HP:0011794)2.93553040
22Nephroblastoma (Wilms tumor) (HP:0002667)2.91226892
23Subaortic stenosis (HP:0001682)2.74223443
24Abnormality of the left ventricular outflow tract (HP:0011103)2.74223443
25Metaphyseal dysplasia (HP:0100255)2.70640393
26Hypoplastic heart (HP:0001961)2.64083832
27Deep philtrum (HP:0002002)2.61082786
28Intestinal atresia (HP:0011100)2.60510048
29Enlarged kidneys (HP:0000105)2.60105013
30Muscle hypertrophy of the lower extremities (HP:0008968)2.55372067
31Subacute progressive viral hepatitis (HP:0006572)2.55328744
32Chronic hepatic failure (HP:0100626)2.51633478
33Absent eyebrow (HP:0002223)2.47697179
34Meningioma (HP:0002858)2.46656929
35Volvulus (HP:0002580)2.46453881
36Vitreoretinal degeneration (HP:0000655)2.44458020
37Atonic seizures (HP:0010819)2.37278546
38Patent foramen ovale (HP:0001655)2.36840431
39Abnormality of the hip-girdle musculature (HP:0001445)2.35432965
40Abnormality of the musculature of the pelvis (HP:0001469)2.35432965
41Adrenal hypoplasia (HP:0000835)2.35316199
42Septo-optic dysplasia (HP:0100842)2.33821219
43Abnormality of the aortic arch (HP:0012303)2.33146707
44Bifid tongue (HP:0010297)2.29759564
45Mesomelia (HP:0003027)2.28567444
46Neonatal hypoglycemia (HP:0001998)2.28505996
47Absent speech (HP:0001344)2.28033114
48Abnormality of the nasal septum (HP:0000419)2.27286169
49Aqueductal stenosis (HP:0002410)2.21692097
50Polyphagia (HP:0002591)2.21138358
51Specific learning disability (HP:0001328)2.20515961
52Poor coordination (HP:0002370)2.18933492
53Broad-based gait (HP:0002136)2.18630195
54Pancreatic cysts (HP:0001737)2.18525463
55Palpebral edema (HP:0100540)2.18393327
56Pachygyria (HP:0001302)2.18150230
57Abnormality of the nasolacrimal system (HP:0000614)2.17975861
58Medial flaring of the eyebrow (HP:0010747)2.17729844
59Nephrogenic diabetes insipidus (HP:0009806)2.17473050
60Abnormality of salivation (HP:0100755)2.17180530
61Pancreatic fibrosis (HP:0100732)2.17082017
62Abnormal lung lobation (HP:0002101)2.16546436
63Congenital primary aphakia (HP:0007707)2.15053903
64Exotropia (HP:0000577)2.15040588
65Epileptic encephalopathy (HP:0200134)2.12230903
66Decreased testicular size (HP:0008734)2.12091973
67Urinary urgency (HP:0000012)2.11497825
68Amyotrophic lateral sclerosis (HP:0007354)2.11325060
69Protruding tongue (HP:0010808)2.11015077
70Abnormality of the phalanges of the 5th finger (HP:0004213)2.10810202
71Gait imbalance (HP:0002141)2.10681681
72Medulloblastoma (HP:0002885)2.09381808
73Abnormality of the ischium (HP:0003174)2.08995487
74Lissencephaly (HP:0001339)2.08204753
75Pheochromocytoma (HP:0002666)2.07439543
76Abnormality of the lacrimal duct (HP:0011481)2.07079757
77Long clavicles (HP:0000890)2.06569096
78Osteomalacia (HP:0002749)2.06525370
79Nephronophthisis (HP:0000090)2.06420068
80Pancreatic islet-cell hyperplasia (HP:0004510)2.05095071
81Optic nerve hypoplasia (HP:0000609)2.04691530
82Short middle phalanx of the 5th finger (HP:0004220)2.03415465
83Abnormality of midbrain morphology (HP:0002418)2.03313370
84Molar tooth sign on MRI (HP:0002419)2.03313370
85Abnormality of the renal cortex (HP:0011035)2.03089434
86Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.03006538
87Postaxial hand polydactyly (HP:0001162)2.02479616
88Exercise-induced muscle cramps (HP:0003710)2.02344402
89Fibular hypoplasia (HP:0003038)2.01646624
90Poor suck (HP:0002033)2.01498619
91Heterochromia iridis (HP:0001100)2.01380180
92Abnormality of the incisor (HP:0000676)2.01159285
9311 pairs of ribs (HP:0000878)2.00321757
94Focal motor seizures (HP:0011153)1.99440672
95Abnormality of the labia minora (HP:0012880)1.98326944
96Astrocytoma (HP:0009592)1.98297412
97Abnormality of the astrocytes (HP:0100707)1.98297412
98Keratoconus (HP:0000563)1.97484653
99Increased corneal curvature (HP:0100692)1.97484653
100Neoplasm of the liver (HP:0002896)1.96588489
101Genital tract atresia (HP:0001827)1.96319501
102Flared iliac wings (HP:0002869)1.96204942
103Neoplasm of the oral cavity (HP:0100649)1.96011058
104Large earlobe (HP:0009748)1.95999248
105Preauricular pit (HP:0004467)1.95829557
106Periauricular skin pits (HP:0100277)1.95829557
107Lower limb muscle weakness (HP:0007340)1.94960705
108Aplasia/Hypoplasia of the tibia (HP:0005772)1.93105654
109Atrial fibrillation (HP:0005110)1.92700491
110Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.92663246
111Abnormality of the corticospinal tract (HP:0002492)1.92604014
112Alveolar cell carcinoma (HP:0006519)1.91562804
113Focal seizures (HP:0007359)1.91292246
114Short foot (HP:0001773)1.91208659
115Hypsarrhythmia (HP:0002521)1.90731006
116Decreased muscle mass (HP:0003199)1.90394863
117Neuroendocrine neoplasm (HP:0100634)1.90326417
118Vaginal atresia (HP:0000148)1.90319251
119Shoulder girdle muscle weakness (HP:0003547)1.89245231
120Micropenis (HP:0000054)1.88570902
121Abnormality of dentin (HP:0010299)1.87651626
122Colon cancer (HP:0003003)1.85745589
123EEG with generalized epileptiform discharges (HP:0011198)1.85328004
124Aplasia/Hypoplasia of the lens (HP:0008063)1.84567106
125Abnormality of the calf musculature (HP:0001430)1.84560043
126Pulmonary artery stenosis (HP:0004415)1.83960981
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83884307
128Broad foot (HP:0001769)1.82717123
129Midline defect of the nose (HP:0004122)1.82610589
130Split foot (HP:0001839)1.82430038
131Absent frontal sinuses (HP:0002688)1.82285359
132Dialeptic seizures (HP:0011146)1.82062456
133Morphological abnormality of the middle ear (HP:0008609)1.82057443
134Narrow forehead (HP:0000341)1.81946800
135Hip dysplasia (HP:0001385)1.81913194
136Abnormality of the antihelix (HP:0009738)1.81451724
137Chorioretinal atrophy (HP:0000533)1.80893121
138Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80850711
139Glioma (HP:0009733)1.80826349
140Hemiparesis (HP:0001269)1.80429174
141Short tibia (HP:0005736)1.79944853
142Progressive inability to walk (HP:0002505)1.79616060
143Pulmonic stenosis (HP:0001642)1.79107407
144Inability to walk (HP:0002540)1.79084986
145Abnormality of the renal medulla (HP:0100957)1.79009333
146Abnormality of the phalanges of the hallux (HP:0010057)1.78341734
147Myotonia (HP:0002486)1.78251382
148Epileptiform EEG discharges (HP:0011182)1.77565081
149Neoplasm of the heart (HP:0100544)1.77312964
150Hypoplastic ischia (HP:0003175)1.77237125
151Epiphyseal dysplasia (HP:0002656)1.76615600
152Renal cortical cysts (HP:0000803)1.75739222
153Abnormality of the frontal sinuses (HP:0002687)1.75614668
154Renal dysplasia (HP:0000110)1.75123327
155Type I transferrin isoform profile (HP:0003642)1.74811772
156Short 4th metacarpal (HP:0010044)1.74311599
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74311599
158Abnormality of the intervertebral disk (HP:0005108)1.73749935
159Neoplasm of the thyroid gland (HP:0100031)1.73603681
160Febrile seizures (HP:0002373)1.72719317
161White forelock (HP:0002211)1.70143720
162Overgrowth (HP:0001548)1.69378811
163Renal hypoplasia (HP:0000089)1.67510006
164Patchy hypopigmentation of hair (HP:0011365)1.67367849
165Postaxial foot polydactyly (HP:0001830)1.66464902
166Cutaneous melanoma (HP:0012056)1.66388599
167Irregular epiphyses (HP:0010582)1.65765088
168Increased number of teeth (HP:0011069)1.65207478
169Aplasia/Hypoplasia of the tongue (HP:0010295)1.65029555
170Scrotal hypoplasia (HP:0000046)1.64911215
171Omphalocele (HP:0001539)1.64794815
172Abnormality of the metopic suture (HP:0005556)1.64594983
173Absent eyelashes (HP:0000561)1.63993551
174Bilateral sensorineural hearing impairment (HP:0008619)1.63931111
175Progressive macrocephaly (HP:0004481)1.63583202
176Abnormal mitochondria in muscle tissue (HP:0008316)1.63348303
177Embryonal neoplasm (HP:0002898)1.63083376
178Preaxial hand polydactyly (HP:0001177)1.63046676
179Occipital encephalocele (HP:0002085)1.62841762
180Primary atrial arrhythmia (HP:0001692)1.62217742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.78301717
2CASK3.75519590
3ERBB33.65028181
4SIK33.01952698
5AKT32.91104405
6SGK22.82638795
7MKNK22.75979457
8FRK2.61463517
9MAP4K22.55272821
10STK38L2.49669662
11STK242.45371198
12OBSCN2.45170854
13MKNK12.39952327
14TRIM282.36875949
15BRSK22.24587397
16PLK22.15304278
17YES12.10712537
18MYLK2.03408887
19BMPR21.97764231
20CDK191.95818709
21NUAK11.84934786
22BCR1.84453219
23SGK4941.80474667
24SGK2231.80474667
25SGK31.77983312
26MAPK131.74704811
27CSNK1G21.70382962
28MAP2K71.65416585
29PRPF4B1.64313640
30BMPR1B1.63281588
31PIK3CA1.55884156
32NTRK21.52723571
33BRD41.50123595
34CSNK1A1L1.49861632
35PLK31.48432007
36LIMK11.45742041
37CSNK1G11.45424389
38CSNK1G31.44952898
39NEK91.44151142
40MAPKAPK51.43644057
41CDK81.43613490
42MAP3K141.30338975
43EPHA41.29607926
44BRSK11.27944201
45MAP2K41.20401900
46NEK61.20293699
47SRPK11.18339096
48FGFR21.17261703
49TRPM71.15528715
50MAP3K121.14620163
51PRKD31.14048659
52PAK31.13683337
53DYRK31.10015369
54PNCK1.02901788
55RPS6KB10.96362294
56UHMK10.96111924
57PLK40.95174313
58MINK10.92479699
59RPS6KA40.88485971
60CCNB10.86746923
61CAMKK20.86735253
62LATS10.85582894
63MUSK0.83417413
64KSR10.82954136
65RPS6KA60.82078280
66STK30.81862667
67PRKCH0.81387519
68WNK30.78073560
69RPS6KC10.75852964
70RPS6KL10.75852964
71EIF2AK30.75415189
72RPS6KA20.75304952
73EIF2AK20.75071072
74PAK60.74307938
75TAOK20.74045878
76STK390.72766683
77INSRR0.69094524
78FLT30.66138612
79TESK10.64894881
80VRK10.64765783
81ERBB40.60845925
82DYRK1B0.59772417
83PRKCE0.59429114
84CHUK0.58980657
85NLK0.58056997
86NTRK10.58031775
87CDK50.57601298
88PKN20.57432208
89MAP3K60.56559867
90DMPK0.55876240
91ADRBK20.55290731
92EIF2AK10.54110819
93PDGFRA0.54066093
94EPHB10.52663045
95OXSR10.51248717
96FGFR10.51187788
97FGFR30.51175792
98TNIK0.50988204
99CSNK1D0.50512073
100DDR20.50207338
101ROCK10.49954023
102CDK30.49164457
103CLK10.48606715
104PIK3CG0.48019339
105BRAF0.47929367
106GRK10.46984223
107TSSK60.45965710
108MARK30.45776623
109CAMK2B0.43870534
110SGK10.43840311
111TIE10.43712077
112EPHA30.43343299
113PRKG20.40856465
114PASK0.39076883
115TGFBR10.37620136
116FER0.36862647
117CAMK1G0.36272315
118PRKACB0.36087956
119MAP3K40.35324508
120DYRK1A0.34038932
121EPHB20.34003695
122DYRK20.33881706
123CDC42BPA0.33853397
124NTRK30.32319796
125CAMK40.32149619
126DAPK20.30120908
127AKT10.29611077
128PRKCG0.28927869
129PRKG10.27827706
130PRKAA10.26521162
131IRAK40.26139515
132SIK20.25825475
133MAP2K10.25251848
134CDK140.24961769
135CSNK2A10.24944112
136EGFR0.24776871
137CAMK2D0.24700461
138GRK70.24304501
139TEC0.23796131
140MAP3K30.23265781
141CAMK2A0.21238960
142LMTK20.20001111
143ADRBK10.19903990
144MARK10.19384088
145PRKCD0.19275958
146PINK10.19211868
147ACVR1B0.19076951
148ATM0.19058090

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.54725689
2Protein export_Homo sapiens_hsa030602.83493852
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42456500
4Butanoate metabolism_Homo sapiens_hsa006502.34080409
5GABAergic synapse_Homo sapiens_hsa047272.32644175
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22508026
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07163976
8SNARE interactions in vesicular transport_Homo sapiens_hsa041301.95778458
9RNA degradation_Homo sapiens_hsa030181.93176174
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89211126
11Endometrial cancer_Homo sapiens_hsa052131.85420443
12Steroid biosynthesis_Homo sapiens_hsa001001.81433460
13Cocaine addiction_Homo sapiens_hsa050301.78468120
14Cell cycle_Homo sapiens_hsa041101.77307168
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.76295932
16Basal transcription factors_Homo sapiens_hsa030221.69983846
17TGF-beta signaling pathway_Homo sapiens_hsa043501.67755995
18Dilated cardiomyopathy_Homo sapiens_hsa054141.55092673
19Glutamatergic synapse_Homo sapiens_hsa047241.53250339
20Olfactory transduction_Homo sapiens_hsa047401.50984393
21Parkinsons disease_Homo sapiens_hsa050121.50255336
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49673570
23Thyroid cancer_Homo sapiens_hsa052161.47929641
24Adherens junction_Homo sapiens_hsa045201.47705912
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42662856
26Hippo signaling pathway_Homo sapiens_hsa043901.40979702
27Non-homologous end-joining_Homo sapiens_hsa034501.39896956
28Propanoate metabolism_Homo sapiens_hsa006401.37901107
29Selenocompound metabolism_Homo sapiens_hsa004501.36474417
30Melanoma_Homo sapiens_hsa052181.32340895
31Huntingtons disease_Homo sapiens_hsa050161.28925579
32Prostate cancer_Homo sapiens_hsa052151.25191233
33Cardiac muscle contraction_Homo sapiens_hsa042601.23184450
34N-Glycan biosynthesis_Homo sapiens_hsa005101.21149113
35Oxidative phosphorylation_Homo sapiens_hsa001901.20470646
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17378939
37Proteasome_Homo sapiens_hsa030501.17058126
38Colorectal cancer_Homo sapiens_hsa052101.14666210
39Phototransduction_Homo sapiens_hsa047441.14457829
40Wnt signaling pathway_Homo sapiens_hsa043101.14188488
41Sulfur metabolism_Homo sapiens_hsa009201.13194544
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10258084
43Circadian entrainment_Homo sapiens_hsa047131.10198066
44Basal cell carcinoma_Homo sapiens_hsa052171.10047894
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08077293
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07498561
47Vibrio cholerae infection_Homo sapiens_hsa051101.07131106
48Base excision repair_Homo sapiens_hsa034101.05707110
49Arachidonic acid metabolism_Homo sapiens_hsa005901.03295926
50beta-Alanine metabolism_Homo sapiens_hsa004101.02890645
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02848325
52mRNA surveillance pathway_Homo sapiens_hsa030151.01375336
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01160502
54Alzheimers disease_Homo sapiens_hsa050101.00423943
55Melanogenesis_Homo sapiens_hsa049161.00152264
56Phagosome_Homo sapiens_hsa041450.97468063
57Serotonergic synapse_Homo sapiens_hsa047260.94459548
58Focal adhesion_Homo sapiens_hsa045100.94141902
59Gap junction_Homo sapiens_hsa045400.94124362
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93107540
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91256210
62Galactose metabolism_Homo sapiens_hsa000520.90915306
63Renin secretion_Homo sapiens_hsa049240.90727091
64Collecting duct acid secretion_Homo sapiens_hsa049660.87817352
65Nucleotide excision repair_Homo sapiens_hsa034200.86665918
66MicroRNAs in cancer_Homo sapiens_hsa052060.84342964
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83840466
68Legionellosis_Homo sapiens_hsa051340.80617947
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80419403
70cAMP signaling pathway_Homo sapiens_hsa040240.80287149
71Regulation of autophagy_Homo sapiens_hsa041400.80128638
72Dopaminergic synapse_Homo sapiens_hsa047280.80058836
73Long-term potentiation_Homo sapiens_hsa047200.79671753
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79218494
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79186600
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78199993
77Peroxisome_Homo sapiens_hsa041460.76873335
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76622288
79Nicotine addiction_Homo sapiens_hsa050330.76621740
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76328974
81Type II diabetes mellitus_Homo sapiens_hsa049300.76251436
82* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75717563
83FoxO signaling pathway_Homo sapiens_hsa040680.75521273
84Synaptic vesicle cycle_Homo sapiens_hsa047210.75436298
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75372256
86Tryptophan metabolism_Homo sapiens_hsa003800.74029741
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73958021
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72259564
89Insulin secretion_Homo sapiens_hsa049110.71959281
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71137144
91Tight junction_Homo sapiens_hsa045300.70686487
92Oocyte meiosis_Homo sapiens_hsa041140.70587728
93Purine metabolism_Homo sapiens_hsa002300.70418771
94Hedgehog signaling pathway_Homo sapiens_hsa043400.70263820
95Taste transduction_Homo sapiens_hsa047420.69884644
96Ras signaling pathway_Homo sapiens_hsa040140.69858388
97Axon guidance_Homo sapiens_hsa043600.66737356
98Alcoholism_Homo sapiens_hsa050340.66255041
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64368875
100Morphine addiction_Homo sapiens_hsa050320.63873254
101Cholinergic synapse_Homo sapiens_hsa047250.63824588
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63231331
103Fanconi anemia pathway_Homo sapiens_hsa034600.62532197
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61027360
105Homologous recombination_Homo sapiens_hsa034400.60700384
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60479747
107Mismatch repair_Homo sapiens_hsa034300.60338838
108Ether lipid metabolism_Homo sapiens_hsa005650.60034140
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59410170
110Pathways in cancer_Homo sapiens_hsa052000.59242276
111Circadian rhythm_Homo sapiens_hsa047100.58930037
112Oxytocin signaling pathway_Homo sapiens_hsa049210.58715874
113Amphetamine addiction_Homo sapiens_hsa050310.56908594
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.56604404
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56043668
116Prolactin signaling pathway_Homo sapiens_hsa049170.55991617
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.53631909
118Hepatitis B_Homo sapiens_hsa051610.51248074
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51155507
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50191547
121Starch and sucrose metabolism_Homo sapiens_hsa005000.50164961
122Rap1 signaling pathway_Homo sapiens_hsa040150.50055600
123Long-term depression_Homo sapiens_hsa047300.49844444
124ABC transporters_Homo sapiens_hsa020100.48610051
125Lysine degradation_Homo sapiens_hsa003100.48365617
126Proteoglycans in cancer_Homo sapiens_hsa052050.48081513
127Epstein-Barr virus infection_Homo sapiens_hsa051690.47918086
128HTLV-I infection_Homo sapiens_hsa051660.47358387
129HIF-1 signaling pathway_Homo sapiens_hsa040660.47170270
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47136087
131Rheumatoid arthritis_Homo sapiens_hsa053230.46638083
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.45430789
133Estrogen signaling pathway_Homo sapiens_hsa049150.45059362
134ECM-receptor interaction_Homo sapiens_hsa045120.45003698
135Glucagon signaling pathway_Homo sapiens_hsa049220.43619259
136Thyroid hormone synthesis_Homo sapiens_hsa049180.42506746
137Type I diabetes mellitus_Homo sapiens_hsa049400.41943084
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.41550852
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41311708
140p53 signaling pathway_Homo sapiens_hsa041150.38200591
141AMPK signaling pathway_Homo sapiens_hsa041520.37790017
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37535577
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36298404
144Protein digestion and absorption_Homo sapiens_hsa049740.36266037
145Inositol phosphate metabolism_Homo sapiens_hsa005620.36052017

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