KLK10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.60640854
2peptide cross-linking (GO:0018149)9.58581086
3keratinocyte differentiation (GO:0030216)8.34956027
4intermediate filament organization (GO:0045109)8.13604437
5skin morphogenesis (GO:0043589)7.52632359
6bundle of His cell to Purkinje myocyte communication (GO:0086069)7.16504347
7epidermis development (GO:0008544)6.82000140
8epidermal cell differentiation (GO:0009913)6.43603448
9multicellular organismal water homeostasis (GO:0050891)6.42804871
10ectoderm development (GO:0007398)5.64857583
11water homeostasis (GO:0030104)5.32504374
12intermediate filament cytoskeleton organization (GO:0045104)5.02859165
13intermediate filament-based process (GO:0045103)4.85400038
14adhesion of symbiont to host cell (GO:0044650)4.79388353
15virion attachment to host cell (GO:0019062)4.79388353
16lipoxygenase pathway (GO:0019372)4.54693810
17diterpenoid biosynthetic process (GO:0016102)4.49115198
18keratinocyte development (GO:0003334)4.40132093
19phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.34521851
20hair follicle morphogenesis (GO:0031069)4.24128790
21adhesion of symbiont to host (GO:0044406)4.19165860
22cell wall macromolecule metabolic process (GO:0044036)4.04516276
23cell wall macromolecule catabolic process (GO:0016998)4.04516276
24negative regulation of cell fate specification (GO:0009996)3.92202676
25atrioventricular valve morphogenesis (GO:0003181)3.91670751
26negative regulation of keratinocyte proliferation (GO:0010839)3.90751822
27citrulline biosynthetic process (GO:0019240)3.89963059
28gap junction assembly (GO:0016264)3.84556214
29terpenoid biosynthetic process (GO:0016114)3.82606517
30keratinocyte proliferation (GO:0043616)3.80886617
31cell-substrate junction assembly (GO:0007044)3.80360752
32regulation of keratinocyte differentiation (GO:0045616)3.77425571
33L-fucose catabolic process (GO:0042355)3.73606445
34fucose catabolic process (GO:0019317)3.73606445
35L-fucose metabolic process (GO:0042354)3.73606445
36phosphatidylcholine acyl-chain remodeling (GO:0036151)3.64794806
37regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.62647149
38skin development (GO:0043588)3.48213958
39phosphatidylserine metabolic process (GO:0006658)3.47223557
40epithelial cell-cell adhesion (GO:0090136)3.45966636
41interferon-gamma secretion (GO:0072643)3.43762970
42phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.41114138
43regulation of cardioblast differentiation (GO:0051890)3.40476455
44behavioral response to nicotine (GO:0035095)3.37783649
45cell aggregation (GO:0098743)3.36696922
46cartilage condensation (GO:0001502)3.36696922
47lateral sprouting from an epithelium (GO:0060601)3.32045258
48epithelium development (GO:0060429)3.26680155
49molting cycle process (GO:0022404)3.26150722
50hair cycle process (GO:0022405)3.26150722
51linoleic acid metabolic process (GO:0043651)3.25682579
52intestinal epithelial cell development (GO:0060576)3.21538653
53regulation of epidermis development (GO:0045682)3.18236312
54negative regulation of interferon-gamma production (GO:0032689)3.16226185
55positive regulation of epidermis development (GO:0045684)3.15596621
56regulation of natural killer cell differentiation (GO:0032823)3.14528672
57polarized epithelial cell differentiation (GO:0030859)3.03569773
58tooth mineralization (GO:0034505)2.99075332
59cytoskeletal anchoring at plasma membrane (GO:0007016)2.93923996
60wound healing, spreading of epidermal cells (GO:0035313)2.93018888
61regulation of epidermal cell differentiation (GO:0045604)2.92669497
62regulation of hair follicle development (GO:0051797)2.92502863
63ventricular cardiac muscle cell action potential (GO:0086005)2.89879267
64detection of bacterium (GO:0016045)2.89597271
65cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88506248
66notochord development (GO:0030903)2.86146289
67negative regulation of cell fate commitment (GO:0010454)2.85212015
68oocyte development (GO:0048599)2.85150458
69one-carbon compound transport (GO:0019755)2.84649582
70chondrocyte development (GO:0002063)2.83236093
71positive regulation of hair cycle (GO:0042635)2.82860989
72positive regulation of hair follicle development (GO:0051798)2.82860989
73transepithelial transport (GO:0070633)2.82667086
74thyroid hormone generation (GO:0006590)2.81775679
75wound healing (GO:0042060)2.80608700
76regulation of cell fate specification (GO:0042659)2.78144294
77magnesium ion transport (GO:0015693)2.77691448
78retinol metabolic process (GO:0042572)2.76550020
79O-glycan processing (GO:0016266)2.76451513
80negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76185825
81cardiac right ventricle morphogenesis (GO:0003215)2.73928659
82kidney morphogenesis (GO:0060993)2.70431151
83protein autoprocessing (GO:0016540)2.69916196
84positive regulation of T cell chemotaxis (GO:0010820)2.68088430
85regulation of T cell chemotaxis (GO:0010819)2.68088430
86positive regulation of epidermal cell differentiation (GO:0045606)2.67838129
87alditol phosphate metabolic process (GO:0052646)2.67628503
88epithelial cell differentiation (GO:0030855)2.66633314
89cardiac conduction (GO:0061337)2.65431810
90fatty acid elongation (GO:0030497)2.61814973
91thyroid hormone metabolic process (GO:0042403)2.61410465
92negative regulation of neurological system process (GO:0031645)2.60661095
93lymph vessel development (GO:0001945)2.58019713
94phosphatidylserine acyl-chain remodeling (GO:0036150)2.56157775
95negative regulation of chondrocyte differentiation (GO:0032331)2.56033273
96retinoic acid metabolic process (GO:0042573)2.55453767
97positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.54673908
98positive regulation of monocyte chemotaxis (GO:0090026)2.53992656
99muscle organ morphogenesis (GO:0048644)2.53922843
100hair follicle development (GO:0001942)2.53632154
101hair cell differentiation (GO:0035315)2.50177807
102pyrimidine-containing compound transmembrane transport (GO:0072531)2.49832127
103planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49029704
104regulation of keratinocyte proliferation (GO:0010837)2.48677681
105long-chain fatty acid biosynthetic process (GO:0042759)2.47357661
106sphingoid metabolic process (GO:0046519)2.46705850
107eyelid development in camera-type eye (GO:0061029)2.46646866
108parturition (GO:0007567)2.45864297
109regulation of ruffle assembly (GO:1900027)2.45384270
110ceramide biosynthetic process (GO:0046513)2.44699404
111regulation of axon regeneration (GO:0048679)2.43112177
112regulation of neuron projection regeneration (GO:0070570)2.43112177
113positive regulation of extracellular matrix organization (GO:1903055)2.43025416
114establishment of planar polarity (GO:0001736)2.42926268
115establishment of tissue polarity (GO:0007164)2.42926268
116citrulline metabolic process (GO:0000052)2.41756240
117regulation of endothelial cell chemotaxis (GO:2001026)2.41429174
118regulation of hair cycle (GO:0042634)2.40520459
119collagen fibril organization (GO:0030199)2.40429724
120regulation of hippo signaling (GO:0035330)2.39547666
121regulation of heart rate by cardiac conduction (GO:0086091)2.38577140
122detection of other organism (GO:0098543)2.37870488
123hypotonic response (GO:0006971)2.37211755
124fibrinolysis (GO:0042730)2.36465553
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35300544
126negative regulation of cartilage development (GO:0061037)2.35236041
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.34886338
128axoneme assembly (GO:0035082)2.34361707
129peptidyl-proline hydroxylation (GO:0019511)2.33690441
130surfactant homeostasis (GO:0043129)2.33663664
131cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32498372
132fucosylation (GO:0036065)2.32183843
133lung-associated mesenchyme development (GO:0060484)2.32104052
134axonemal dynein complex assembly (GO:0070286)2.30712445
135regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30688315
136phosphatidylinositol acyl-chain remodeling (GO:0036149)2.30125790
137regulation of myelination (GO:0031641)2.29100869
138negative regulation of T cell differentiation in thymus (GO:0033085)2.28996005
139keratan sulfate catabolic process (GO:0042340)2.28168986
140L-serine transport (GO:0015825)2.27782834
141cornea development in camera-type eye (GO:0061303)2.26894910
142mesodermal cell differentiation (GO:0048333)2.26509265
143endodermal cell differentiation (GO:0035987)2.25177931
144negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.24316327
145renal system development (GO:0072001)2.24062310
146odontogenesis (GO:0042476)2.24048321
147regulation of mesoderm development (GO:2000380)2.22744643
148cell communication involved in cardiac conduction (GO:0086065)2.22584673
149rRNA catabolic process (GO:0016075)2.22056802
150negative regulation of stress fiber assembly (GO:0051497)2.21716602
151hair cycle (GO:0042633)18.9050046
152molting cycle (GO:0042303)18.9050046
153keratinization (GO:0031424)18.5110075
154desmosome organization (GO:0002934)12.5213221
155establishment of skin barrier (GO:0061436)10.6126642
156hemidesmosome assembly (GO:0031581)10.4615961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.99805301
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83702015
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.50486581
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.02282167
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83213954
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.79080585
7VDR_22108803_ChIP-Seq_LS180_Human2.62541476
8ZNF263_19887448_ChIP-Seq_K562_Human2.58419957
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.52489476
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50037290
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.29839243
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.26344015
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.26344015
14SOX9_24532713_ChIP-Seq_HFSC_Mouse2.06594444
15ZNF274_21170338_ChIP-Seq_K562_Hela2.01672321
16TP63_17297297_ChIP-ChIP_HaCaT_Human15.3614002
17HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91979374
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89682886
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88744113
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70699942
21* ATF3_27146783_Chip-Seq_COLON_Human1.67809177
22RACK7_27058665_Chip-Seq_MCF-7_Human1.66957106
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.59596443
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54081480
25* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49904122
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46591657
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44368796
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41212230
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39348459
30ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35597189
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34550165
32GATA3_24758297_ChIP-Seq_MCF-7_Human1.33627452
33* SOX2_20726797_ChIP-Seq_SW620_Human1.33327920
34CJUN_26792858_Chip-Seq_BT549_Human1.27756616
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25831132
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25790993
37EGR1_19032775_ChIP-ChIP_M12_Human1.25248528
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24881022
39LXR_22292898_ChIP-Seq_THP-1_Human1.20918913
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.19738406
41CTCF_20526341_ChIP-Seq_ESCs_Human1.18619723
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18071445
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.17844385
44AR_21572438_ChIP-Seq_LNCaP_Human1.17362610
45KLF5_25053715_ChIP-Seq_YYC3_Human1.16822915
46FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16486896
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.16443308
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15651703
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14379261
50TP63_22573176_ChIP-Seq_HFKS_Human1.14290147
51CLOCK_20551151_ChIP-Seq_293T_Human1.13608090
52JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13087501
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12963717
54TP63_23658742_ChIP-Seq_EP156T_Human1.11953734
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.10420177
56GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09305991
57ERG_20517297_ChIP-Seq_VCAP_Human1.09045729
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08214506
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07431947
60FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07156585
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.07010730
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07010730
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06771249
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04996921
65CTCF_27219007_Chip-Seq_Bcells_Human1.04329888
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03692672
67CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03319557
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02779597
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.02758065
70AR_20517297_ChIP-Seq_VCAP_Human1.02664384
71AR_25329375_ChIP-Seq_VCAP_Human1.02077547
72P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01681246
73E2F1_20622854_ChIP-Seq_HELA_Human1.01268976
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01039273
75GATA4_25053715_ChIP-Seq_YYC3_Human1.00124906
76BCAT_22108803_ChIP-Seq_LS180_Human0.99539921
77P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98671742
78NCOR_22424771_ChIP-Seq_293T_Human0.98310640
79RBPJ_21746931_ChIP-Seq_IB4_Human0.97581248
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96514309
81TCF4_22108803_ChIP-Seq_LS180_Human0.95669110
82P53_21459846_ChIP-Seq_SAOS-2_Human0.95582568
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94401731
84BCOR_27268052_Chip-Seq_Bcells_Human0.93995185
85HOXB7_26014856_ChIP-Seq_BT474_Human0.93910250
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93833710
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93765815
88TAF2_19829295_ChIP-Seq_ESCs_Human0.93674345
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93282808
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93152111
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93152111
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93152111
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.93014524
94RXR_22108803_ChIP-Seq_LS180_Human0.92721689
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92679353
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91992222
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.91695309
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.90614322
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.90456335
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90151668
101NANOG_20526341_ChIP-Seq_ESCs_Human0.89378372
102* GATA6_25053715_ChIP-Seq_YYC3_Human0.88942132
103GBX2_23144817_ChIP-Seq_PC3_Human0.88821166
104SMAD3_21741376_ChIP-Seq_HESCs_Human0.88032098
105YY1_22570637_ChIP-Seq_MALME-3M_Human0.87880470
106TP53_18474530_ChIP-ChIP_U2OS_Human0.87554279
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87475724
108SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87425948
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87416603
110CDX2_22108803_ChIP-Seq_LS180_Human0.86274671
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.85425132
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84428647
113ERA_21632823_ChIP-Seq_H3396_Human0.83892376
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83073946
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.82798386
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.82678712
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82075735
118MYC_19829295_ChIP-Seq_ESCs_Human0.81301656
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81293417
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80803240
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80803240
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.80588856
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79718576
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77737824
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76770070
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76749233
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75179593
128* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74091476
129BCL6_27268052_Chip-Seq_Bcells_Human0.74027651
130* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.73466137
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.72687511
132SMC4_20622854_ChIP-Seq_HELA_Human0.72427338
133KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72217653
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.72172223
135STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71794332
136P68_20966046_ChIP-Seq_HELA_Human0.71614897
137AHR_22903824_ChIP-Seq_MCF-7_Human0.68655991
138KDM2B_26808549_Chip-Seq_K562_Human0.65044279
139MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.64784943
140TP53_16413492_ChIP-PET_HCT116_Human0.62972921
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62933611
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62813672
143RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62321365
144FOXH1_21741376_ChIP-Seq_ESCs_Human0.61645373
145TBX20_22080862_ChIP-Seq_HEART_Mouse0.61584166
146TBX20_22328084_ChIP-Seq_HEART_Mouse0.61584166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.19252030
2MP0000579_abnormal_nail_morphology6.19717035
3MP0005275_abnormal_skin_tensile6.06041912
4MP0005501_abnormal_skin_physiology4.60186901
5MP0010234_abnormal_vibrissa_follicle4.54595541
6MP0000647_abnormal_sebaceous_gland3.77431802
7MP0002098_abnormal_vibrissa_morphology3.58760251
8MP0003705_abnormal_hypodermis_morpholog3.57185395
9MP0004885_abnormal_endolymph3.17451566
10MP0001216_abnormal_epidermal_layer3.17170301
11MP0002060_abnormal_skin_morphology3.09370147
12MP0000467_abnormal_esophagus_morphology3.09142679
13MP0000383_abnormal_hair_follicle3.00085469
14MP0010678_abnormal_skin_adnexa2.98356012
15MP0000762_abnormal_tongue_morphology2.91024026
16MP0000377_abnormal_hair_follicle2.90847933
17MP0003453_abnormal_keratinocyte_physiol2.89310083
18MP0002254_reproductive_system_inflammat2.81217629
19MP0010771_integument_phenotype2.78619095
20MP0004381_abnormal_hair_follicle2.61101237
21MP0000427_abnormal_hair_cycle2.51144007
22MP0004947_skin_inflammation2.29235259
23MP0003566_abnormal_cell_adhesion2.28151391
24MP0003878_abnormal_ear_physiology2.23070545
25MP0005377_hearing/vestibular/ear_phenot2.23070545
26MP0002234_abnormal_pharynx_morphology2.22664639
27MP0004043_abnormal_pH_regulation2.12450514
28MP0003941_abnormal_skin_development2.05633123
29MP0001243_abnormal_dermal_layer1.98859572
30MP0002282_abnormal_trachea_morphology1.82449716
31MP0009931_abnormal_skin_appearance1.62057713
32MP0000367_abnormal_coat/_hair1.58596934
33MP0009053_abnormal_anal_canal1.38486520
34MP0001191_abnormal_skin_condition1.30109695
35MP0001849_ear_inflammation1.27096046
36MP0005023_abnormal_wound_healing1.20511866
37MP0003011_delayed_dark_adaptation1.19904639
38MP0001851_eye_inflammation1.14857420
39MP0010352_gastrointestinal_tract_polyps1.13973678
40MP0004185_abnormal_adipocyte_glucose1.13848059
41MP0008875_abnormal_xenobiotic_pharmacok1.13536612
42MP0002876_abnormal_thyroid_physiology1.02977062
43MP0003755_abnormal_palate_morphology1.02146365
44MP0001346_abnormal_lacrimal_gland1.00423573
45MP0001485_abnormal_pinna_reflex0.99995549
46MP0005248_abnormal_Harderian_gland0.95472874
47MP0010030_abnormal_orbit_morphology0.94467007
48MP0009780_abnormal_chondrocyte_physiolo0.94337688
49MP0004272_abnormal_basement_membrane0.94055449
50MP0002933_joint_inflammation0.93575306
51MP0008438_abnormal_cutaneous_collagen0.93448601
52MP0002249_abnormal_larynx_morphology0.91691322
53MP0000465_gastrointestinal_hemorrhage0.85271878
54MP0001340_abnormal_eyelid_morphology0.83225932
55MP0002653_abnormal_ependyma_morphology0.83197411
56MP0005083_abnormal_biliary_tract0.83042257
57MP0000470_abnormal_stomach_morphology0.83003574
58MP0004264_abnormal_extraembryonic_tissu0.82140198
59MP0004019_abnormal_vitamin_homeostasis0.76699380
60MP0005451_abnormal_body_composition0.76600006
61MP0005076_abnormal_cell_differentiation0.75911348
62MP0002877_abnormal_melanocyte_morpholog0.75563471
63MP0009379_abnormal_foot_pigmentation0.72951252
64MP0003191_abnormal_cellular_cholesterol0.71833325
65MP0001765_abnormal_ion_homeostasis0.71676358
66MP0002111_abnormal_tail_morphology0.71165800
67MP0005409_darkened_coat_color0.70760487
68MP0003638_abnormal_response/metabolism_0.70498267
69MP0005508_abnormal_skeleton_morphology0.69234143
70MP0000163_abnormal_cartilage_morphology0.68744942
71MP0002896_abnormal_bone_mineralization0.68350047
72MP0003315_abnormal_perineum_morphology0.67644260
73MP0002233_abnormal_nose_morphology0.67479601
74MP0000627_abnormal_mammary_gland0.67138948
75MP0009250_abnormal_appendicular_skeleto0.67076638
76MP0001502_abnormal_circadian_rhythm0.65790033
77MP0001784_abnormal_fluid_regulation0.63799643
78MP0000566_synostosis0.61809865
79MP0001188_hyperpigmentation0.60971441
80MP0004134_abnormal_chest_morphology0.60574418
81MP0003448_altered_tumor_morphology0.59341650
82MP0004133_heterotaxia0.58699831
83MP0001542_abnormal_bone_strength0.58224118
84MP0008789_abnormal_olfactory_epithelium0.57806120
85MP0000538_abnormal_urinary_bladder0.57548176
86MP0002138_abnormal_hepatobiliary_system0.57044654
87MP0002102_abnormal_ear_morphology0.56320543
88MP0002115_abnormal_skeleton_extremities0.54849734
89MP0008872_abnormal_physiological_respon0.54362345
90MP0000432_abnormal_head_morphology0.54251151
91MP0002095_abnormal_skin_pigmentation0.53117942
92MP0000750_abnormal_muscle_regeneration0.52183989
93MP0005503_abnormal_tendon_morphology0.51711131
94MP0003950_abnormal_plasma_membrane0.50515675
95MP0010386_abnormal_urinary_bladder0.50491923
96MP0000733_abnormal_muscle_development0.49741491
97MP0001905_abnormal_dopamine_level0.48740401
98MP0000613_abnormal_salivary_gland0.48151659
99MP0005390_skeleton_phenotype0.47853249
100MP0000678_abnormal_parathyroid_gland0.47623154
101MP0000569_abnormal_digit_pigmentation0.47599121
102MP0006072_abnormal_retinal_apoptosis0.45352948
103MP0004782_abnormal_surfactant_physiolog0.45345121
104MP0001919_abnormal_reproductive_system0.44997918
105MP0000537_abnormal_urethra_morphology0.44209679
106MP0001299_abnormal_eye_distance/0.44196223
107MP0000751_myopathy0.43810891
108MP0001664_abnormal_digestion0.42652043
109MP0000049_abnormal_middle_ear0.42392040
110MP0004197_abnormal_fetal_growth/weight/0.42366185
111MP0002909_abnormal_adrenal_gland0.41793009
112MP0002109_abnormal_limb_morphology0.41775155
113MP0002177_abnormal_outer_ear0.41720211
114MP0001984_abnormal_olfaction0.41289557
115MP0009384_cardiac_valve_regurgitation0.41289155
116MP0003119_abnormal_digestive_system0.40718633
117MP0002113_abnormal_skeleton_development0.40399669
118MP0002089_abnormal_postnatal_growth/wei0.40115990
119MP0000026_abnormal_inner_ear0.39713646
120MP0003935_abnormal_craniofacial_develop0.39657842
121MP0001533_abnormal_skeleton_physiology0.39403816
122MP0005394_taste/olfaction_phenotype0.39309772
123MP0005499_abnormal_olfactory_system0.39309772
124MP0005551_abnormal_eye_electrophysiolog0.37833572
125MP0005193_abnormal_anterior_eye0.37807763
126MP0003937_abnormal_limbs/digits/tail_de0.36974159
127MP0005666_abnormal_adipose_tissue0.35255954
128MP0002697_abnormal_eye_size0.33917170
129MP0003385_abnormal_body_wall0.33747737
130MP0009643_abnormal_urine_homeostasis0.33145783
131MP0001286_abnormal_eye_development0.33128990
132MP0003283_abnormal_digestive_organ0.33087742
133MP0003936_abnormal_reproductive_system0.32857683
134MP0003045_fibrosis0.32685016
135MP0003795_abnormal_bone_structure0.32019661
136MP0003436_decreased_susceptibility_to0.31976367
137MP0002136_abnormal_kidney_physiology0.29451336
138MP0001756_abnormal_urination0.28605566
139MP0005389_reproductive_system_phenotype0.26324865
140MP0002733_abnormal_thermal_nociception0.24659424
141MP0001324_abnormal_eye_pigmentation0.24150999

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.59132866
2Hypotrichosis (HP:0001006)8.03353412
3Onycholysis (HP:0001806)6.84380897
4Increased IgE level (HP:0003212)6.62623103
5Woolly hair (HP:0002224)6.56284201
6Plantar hyperkeratosis (HP:0007556)6.31206265
7Fragile nails (HP:0001808)6.23409620
8Palmoplantar hyperkeratosis (HP:0000972)5.94513285
9Thick nail (HP:0001805)5.92301417
10Pili torti (HP:0003777)5.63376044
11Palmar hyperkeratosis (HP:0010765)5.61015834
12Right ventricular cardiomyopathy (HP:0011663)5.49989988
13Oral leukoplakia (HP:0002745)5.49365104
14Milia (HP:0001056)5.24278405
15Nail dystrophy (HP:0008404)4.72855911
16Alopecia of scalp (HP:0002293)4.65358512
17Follicular hyperkeratosis (HP:0007502)4.48679259
18Erythema (HP:0010783)4.06711698
19Epiphyseal dysplasia (HP:0002656)4.00600922
20Abnormality of secondary sexual hair (HP:0009888)4.00010268
21Abnormality of the axillary hair (HP:0100134)4.00010268
22Abnormal blistering of the skin (HP:0008066)3.91625053
23Irregular epiphyses (HP:0010582)3.75294268
24Erythroderma (HP:0001019)3.63032277
25Vitreoretinal degeneration (HP:0000655)3.50386716
26Pustule (HP:0200039)3.49491091
27Congenital ichthyosiform erythroderma (HP:0007431)3.42179408
28Conjunctival hamartoma (HP:0100780)3.38522083
29Furrowed tongue (HP:0000221)3.37390920
30Abnormal hair laboratory examination (HP:0003328)3.30908047
31Atrophic scars (HP:0001075)3.28873419
32Hypoplastic ischia (HP:0003175)3.23356494
33Absent eyelashes (HP:0000561)3.21933967
34Abnormality of hair growth rate (HP:0011363)3.14356361
35Slow-growing hair (HP:0002217)3.14356361
36Brittle hair (HP:0002299)3.02705904
37Sparse scalp hair (HP:0002209)3.01733663
38Cupped ribs (HP:0000887)2.99910861
39Absent hair (HP:0002298)2.92644021
40Abnormality of the ischium (HP:0003174)2.80656998
41Ridged nail (HP:0001807)2.78221666
42Amniotic constriction ring (HP:0009775)2.77792584
43Abnormality of placental membranes (HP:0011409)2.77792584
44Sparse eyelashes (HP:0000653)2.77566775
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.76293043
46Curly hair (HP:0002212)2.74696063
47Advanced eruption of teeth (HP:0006288)2.70586569
48Palmoplantar keratoderma (HP:0000982)2.62150046
49Anonychia (HP:0001798)2.55949900
50Hypoplastic labia majora (HP:0000059)2.51216887
51Flat acetabular roof (HP:0003180)2.51036733
52Distal lower limb muscle weakness (HP:0009053)2.48450648
53Natal tooth (HP:0000695)2.48348528
54Ventricular tachycardia (HP:0004756)2.44263197
55Dehydration (HP:0001944)2.43133559
56Small epiphyses (HP:0010585)2.42710455
57Neonatal short-limb short stature (HP:0008921)2.41974419
58Ectropion (HP:0000656)2.40643203
59Hypohidrosis (HP:0000966)2.38442310
60Oligodontia (HP:0000677)2.35183699
61Aplasia cutis congenita (HP:0001057)2.31137578
62Tubular atrophy (HP:0000092)2.30722513
63Abnormality of the salivary glands (HP:0010286)2.28466947
64Genu varum (HP:0002970)2.28277038
65Abnormal tarsal ossification (HP:0008369)2.27816540
66Laryngomalacia (HP:0001601)2.26936641
67Hypoplasia of dental enamel (HP:0006297)2.26481390
68Abnormality of the labia majora (HP:0012881)2.23474325
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23270428
70Corneal erosion (HP:0200020)2.18954418
71Gangrene (HP:0100758)2.16371767
72Increased connective tissue (HP:0009025)2.15993847
73Flat capital femoral epiphysis (HP:0003370)2.14663686
74Chronic bronchitis (HP:0004469)2.13950106
75Delayed epiphyseal ossification (HP:0002663)2.13758173
76Type 1 muscle fiber predominance (HP:0003803)2.09774619
77Popliteal pterygium (HP:0009756)2.07979190
78Hyperactive renin-angiotensin system (HP:0000841)2.07567023
79Hamartoma of the eye (HP:0010568)2.05582828
80Ulnar deviation of the wrist (HP:0003049)2.01916244
81Parakeratosis (HP:0001036)1.98744481
82Corneal dystrophy (HP:0001131)1.96980096
83Fatigable weakness (HP:0003473)1.95598923
84Abnormality of the neuromuscular junction (HP:0003398)1.95598923
85Labial hypoplasia (HP:0000066)1.93192516
86Hypoplasia of the uterus (HP:0000013)1.93076752
87Lip pit (HP:0100267)1.92148410
88Hyporeflexia of lower limbs (HP:0002600)1.90624099
89Metaphyseal cupping (HP:0003021)1.90063417
90Carious teeth (HP:0000670)1.89800941
91Pruritus (HP:0000989)1.87687423
92Acanthosis nigricans (HP:0000956)1.87145543
93Hyperhidrosis (HP:0000975)1.86690974
94Dry hair (HP:0011359)1.86257972
95Concave nail (HP:0001598)1.85607714
96Recurrent corneal erosions (HP:0000495)1.84916518
97Selective tooth agenesis (HP:0001592)1.83590719
98Abnormal vertebral ossification (HP:0100569)1.83431105
99Aplasia/hypoplasia of the uterus (HP:0008684)1.83308730
100Blepharitis (HP:0000498)1.82392319
101Pancreatic cysts (HP:0001737)1.78328259
102Hypergammaglobulinemia (HP:0010702)1.76807116
103Abnormality of the frontal sinuses (HP:0002687)1.76790200
104Round ear (HP:0100830)1.76756599
105Amelogenesis imperfecta (HP:0000705)1.75913397
106Abnormality of midbrain morphology (HP:0002418)1.75699435
107Molar tooth sign on MRI (HP:0002419)1.75699435
108Autoamputation (HP:0001218)1.73732535
109Hypoplastic female external genitalia (HP:0012815)1.71475780
110Osteoarthritis (HP:0002758)1.71285044
111Muscle fiber splitting (HP:0003555)1.71278161
112Conical tooth (HP:0000698)1.70634687
113Multifactorial inheritance (HP:0001426)1.69765613
114Neck muscle weakness (HP:0000467)1.68874601
115Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68102354
116Bronchomalacia (HP:0002780)1.68046951
117Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.67571511
118Fragile skin (HP:0001030)1.67186234
119True hermaphroditism (HP:0010459)1.66296724
120Decreased circulating renin level (HP:0003351)1.64544543
121Fine hair (HP:0002213)1.63614508
122Muscle fiber inclusion bodies (HP:0100299)1.62887554
123Esophageal atresia (HP:0002032)1.62291155
124Abnormal foot bone ossification (HP:0010675)1.61568948
125Renal salt wasting (HP:0000127)1.61324731
126Nemaline bodies (HP:0003798)1.59937809
127Cervical subluxation (HP:0003308)1.59643953
128Pterygium (HP:0001059)1.58984048
129Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.58406181
130Abnormality of femoral epiphyses (HP:0006499)1.58406181
131Hypodontia (HP:0000668)1.58126760
132Hip contracture (HP:0003273)1.57361000
133Distal arthrogryposis (HP:0005684)1.57333845
134Dry skin (HP:0000958)1.56424802
135Abnormality of the fingernails (HP:0001231)1.54886627
136Congenital, generalized hypertrichosis (HP:0004540)1.53766168
137Premature rupture of membranes (HP:0001788)1.53337788
138Breast hypoplasia (HP:0003187)1.52514809
139Achilles tendon contracture (HP:0001771)1.52064405
140Absent epiphyses (HP:0010577)1.51444209
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51444209
142Duplicated collecting system (HP:0000081)1.51009679
143Abnormality of the renal medulla (HP:0100957)1.49803248
144Absent/shortened dynein arms (HP:0200106)1.49761237
145Dynein arm defect of respiratory motile cilia (HP:0012255)1.49761237
146Abnormal respiratory motile cilium morphology (HP:0005938)1.49324103
147Abnormal respiratory epithelium morphology (HP:0012253)1.49324103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.95544209
2MAP3K34.53642232
3FER3.97737784
4MAPKAPK33.78622666
5MST43.24629178
6LATS12.74052615
7FRK2.61237890
8EPHB22.55441168
9TAOK12.53483026
10NME12.53314710
11DDR22.49386510
12RPS6KB22.37837389
13ERN12.26530790
14MST1R2.23546260
15TTN2.21583213
16TRIB32.14033090
17MAP3K112.06834847
18TGFBR12.03593857
19TRPM72.02405189
20ERBB31.96474819
21ADRBK21.90719183
22WNK41.88204153
23LMTK21.87854789
24EPHB11.84801623
25STK391.82037823
26PIK3CG1.67279840
27STK38L1.61434660
28BMPR1B1.55701119
29EPHA31.53892940
30GRK11.52522101
31MAP3K121.50875993
32PIM21.50566532
33STK241.49323452
34RPS6KA41.47659504
35MAP2K31.39201342
36FGFR11.34283032
37CASK1.34193405
38BCR1.30543774
39TLK11.29834063
40MAPK151.29589938
41MET1.29377624
42PIK3CA1.26709451
43MAP3K21.26164205
44RIPK11.22986267
45LRRK21.22002840
46SIK11.20629716
47PTK61.18144859
48BMX1.16104697
49TAOK21.15007352
50TESK11.08782504
51PHKG21.08570965
52PHKG11.08570965
53EEF2K1.08495112
54MAP4K21.08138030
55OXSR11.07685077
56PKN21.06473133
57LATS21.05207190
58IRAK11.05193610
59PTK21.01251471
60MAP3K60.98659957
61STK100.97495918
62WNK30.95969793
63DYRK1B0.93628231
64MATK0.92727231
65CDK60.90007180
66MAP3K10.89533012
67STK30.86343813
68PRKCE0.84071076
69FLT30.81900874
70MUSK0.81111332
71FGFR40.73662976
72PRKCI0.72758885
73LIMK10.71575095
74FGFR30.70586585
75PINK10.70332671
76NUAK10.69503017
77TGFBR20.64923782
78PRKG20.64360428
79DAPK20.63766833
80MAPKAPK20.63048862
81MAP2K60.62547255
82WNK10.62183337
83BLK0.61527734
84IRAK30.61100072
85IKBKB0.60888304
86TXK0.60865689
87TAOK30.60426996
88CAMK1D0.58521648
89NTRK10.58454124
90OBSCN0.57569822
91NME20.57349947
92PAK40.55770941
93MAP3K40.54653341
94MAP3K80.54075262
95MAP2K10.53899955
96TRIM280.53045389
97MAP3K90.51134565
98ZAK0.48696855
99GSK3A0.48625396
100PDGFRB0.46111834
101INSRR0.45954449
102ERBB20.44309528
103ACVR1B0.43115637
104NEK10.42973378
105SGK4940.42353387
106SGK2230.42353387
107RPS6KA10.41334838
108PNCK0.41325199
109MAPK120.41136663
110DYRK20.41038990
111MAP2K20.39627968
112PBK0.38244621
113CAMK1G0.37317363
114PAK20.36528201
115IRAK40.35437603
116ROCK10.33854525
117PRKD10.33752522
118ILK0.33541946
119SIK30.32429838
120NLK0.31852614
121TIE10.31612977
122PDGFRA0.30339210
123IGF1R0.29490977
124CSNK1A10.29426713
125CDK80.29351683
126CSK0.28765661
127EGFR0.28009954
128MTOR0.27905760
129MAP2K70.27267220
130PRKCZ0.25632743
131PRKCQ0.25328021
132PRKD20.23171470
133MAP3K50.22816441
134PRKCG0.22476206
135DMPK0.21809464
136ABL10.21442654
137RPS6KA60.21067010
138STK380.20529705
139ROCK20.20438154
140AURKB0.18531118
141MAPK40.18393364
142ALK0.18321918
143PAK30.17928010
144PRKCD0.17481810
145SRC0.16595226
146PIM10.16269394
147CHUK0.15838142
148PRKAA20.14877114
149RPS6KA20.14868798
150GRK60.13738291
151PRKCA0.13693565
152PRKD30.12946568
153TBK10.11071608
154AKT20.10680880
155HCK0.10016903
156MAPK90.09954670
157PDK20.09742961
158MAPK70.09632920
159DYRK1A0.09611918
160ADRBK10.09214432
161MAP3K70.08777584
162ABL20.08712339

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.15505000
2ECM-receptor interaction_Homo sapiens_hsa045124.03002172
3Phenylalanine metabolism_Homo sapiens_hsa003603.35121337
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.00781520
5Phototransduction_Homo sapiens_hsa047442.95269285
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.94049757
7Linoleic acid metabolism_Homo sapiens_hsa005912.35156094
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27151664
9Basal cell carcinoma_Homo sapiens_hsa052172.17239714
10Bladder cancer_Homo sapiens_hsa052192.12769690
11Adherens junction_Homo sapiens_hsa045202.10679343
12Hippo signaling pathway_Homo sapiens_hsa043902.06777950
13Proteoglycans in cancer_Homo sapiens_hsa052052.06399266
14Protein digestion and absorption_Homo sapiens_hsa049741.98147161
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97018439
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94436942
17Focal adhesion_Homo sapiens_hsa045101.90959390
18Nitrogen metabolism_Homo sapiens_hsa009101.86718809
19Sulfur metabolism_Homo sapiens_hsa009201.77638025
20Arachidonic acid metabolism_Homo sapiens_hsa005901.75971252
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.74274646
22Histidine metabolism_Homo sapiens_hsa003401.72871943
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72737063
24Tyrosine metabolism_Homo sapiens_hsa003501.71568935
25Steroid biosynthesis_Homo sapiens_hsa001001.66841076
26Tight junction_Homo sapiens_hsa045301.66832950
27Fat digestion and absorption_Homo sapiens_hsa049751.59446742
28Chemical carcinogenesis_Homo sapiens_hsa052041.55207887
29Ovarian steroidogenesis_Homo sapiens_hsa049131.53777191
30Hedgehog signaling pathway_Homo sapiens_hsa043401.51841428
31Acute myeloid leukemia_Homo sapiens_hsa052211.51531574
32VEGF signaling pathway_Homo sapiens_hsa043701.48227707
33Amoebiasis_Homo sapiens_hsa051461.47914205
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45084271
35TGF-beta signaling pathway_Homo sapiens_hsa043501.42942954
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38262199
37Retinol metabolism_Homo sapiens_hsa008301.38233792
38Thyroid cancer_Homo sapiens_hsa052161.37181260
39Serotonergic synapse_Homo sapiens_hsa047261.36840819
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35852701
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.34491349
42Circadian rhythm_Homo sapiens_hsa047101.32425847
43Small cell lung cancer_Homo sapiens_hsa052221.31438656
44Melanogenesis_Homo sapiens_hsa049161.22836049
45Fatty acid elongation_Homo sapiens_hsa000621.22829578
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21949732
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20467804
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.18873552
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16743428
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.16076232
51MicroRNAs in cancer_Homo sapiens_hsa052061.15643094
52Salivary secretion_Homo sapiens_hsa049701.13539214
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12190020
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11853486
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09319578
56Sphingolipid metabolism_Homo sapiens_hsa006001.07483753
57Ribosome_Homo sapiens_hsa030101.07413907
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05977677
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05791520
60Toxoplasmosis_Homo sapiens_hsa051451.03003243
61Nicotine addiction_Homo sapiens_hsa050331.01820298
62Taste transduction_Homo sapiens_hsa047421.01621411
63GnRH signaling pathway_Homo sapiens_hsa049121.01348462
64ABC transporters_Homo sapiens_hsa020101.00915654
65Malaria_Homo sapiens_hsa051441.00716374
66Glioma_Homo sapiens_hsa052141.00460535
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99216182
68PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96997853
69beta-Alanine metabolism_Homo sapiens_hsa004100.96839565
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.95656417
71Oxidative phosphorylation_Homo sapiens_hsa001900.95449723
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.94858756
73p53 signaling pathway_Homo sapiens_hsa041150.94733967
74Axon guidance_Homo sapiens_hsa043600.93134427
75Ether lipid metabolism_Homo sapiens_hsa005650.90555030
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90417202
77Dilated cardiomyopathy_Homo sapiens_hsa054140.88939940
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88237610
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87814152
80Wnt signaling pathway_Homo sapiens_hsa043100.84591270
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84429705
82Endometrial cancer_Homo sapiens_hsa052130.84307207
83Protein export_Homo sapiens_hsa030600.83607706
84Renal cell carcinoma_Homo sapiens_hsa052110.82418280
85Pertussis_Homo sapiens_hsa051330.82066508
86Selenocompound metabolism_Homo sapiens_hsa004500.79670707
87HIF-1 signaling pathway_Homo sapiens_hsa040660.79115431
88Tryptophan metabolism_Homo sapiens_hsa003800.77025812
89Pathways in cancer_Homo sapiens_hsa052000.75374869
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73760061
91Collecting duct acid secretion_Homo sapiens_hsa049660.69506928
92ErbB signaling pathway_Homo sapiens_hsa040120.68541587
93Rap1 signaling pathway_Homo sapiens_hsa040150.68181850
94Pancreatic cancer_Homo sapiens_hsa052120.67740237
95Glutamatergic synapse_Homo sapiens_hsa047240.67260400
96Glycerolipid metabolism_Homo sapiens_hsa005610.65024369
97Hepatitis C_Homo sapiens_hsa051600.64539458
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64096120
99Dorso-ventral axis formation_Homo sapiens_hsa043200.63639315
100Vibrio cholerae infection_Homo sapiens_hsa051100.62510108
101Olfactory transduction_Homo sapiens_hsa047400.62392473
102Ras signaling pathway_Homo sapiens_hsa040140.62006707
103Basal transcription factors_Homo sapiens_hsa030220.60894925
104Alzheimers disease_Homo sapiens_hsa050100.60550648
105Insulin resistance_Homo sapiens_hsa049310.60506389
106Caffeine metabolism_Homo sapiens_hsa002320.60311393
107Glutathione metabolism_Homo sapiens_hsa004800.58537010
108Platelet activation_Homo sapiens_hsa046110.58290320
109Chronic myeloid leukemia_Homo sapiens_hsa052200.57454985
110Melanoma_Homo sapiens_hsa052180.57450928
111Butanoate metabolism_Homo sapiens_hsa006500.57396588
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57184673
113Apoptosis_Homo sapiens_hsa042100.55514505
114Shigellosis_Homo sapiens_hsa051310.55080245
115Notch signaling pathway_Homo sapiens_hsa043300.55032250
116TNF signaling pathway_Homo sapiens_hsa046680.54275289
117Estrogen signaling pathway_Homo sapiens_hsa049150.53076749
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.52004821
119Non-small cell lung cancer_Homo sapiens_hsa052230.51214335
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51069804
121Long-term depression_Homo sapiens_hsa047300.50682275
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50647303
123Fatty acid biosynthesis_Homo sapiens_hsa000610.50422830
124Prostate cancer_Homo sapiens_hsa052150.50196939
125Pancreatic secretion_Homo sapiens_hsa049720.49020978
126Phagosome_Homo sapiens_hsa041450.48078812
127Cardiac muscle contraction_Homo sapiens_hsa042600.46848101
128HTLV-I infection_Homo sapiens_hsa051660.46768436
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.45623402
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.44077053
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42518422
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.41577947
133Huntingtons disease_Homo sapiens_hsa050160.40213615
134Metabolic pathways_Homo sapiens_hsa011000.39755321
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39503856
136Mineral absorption_Homo sapiens_hsa049780.39451378
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39430265
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38770510
139Insulin secretion_Homo sapiens_hsa049110.37553609
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.37062196
141Circadian entrainment_Homo sapiens_hsa047130.37003355
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35003751
143Salmonella infection_Homo sapiens_hsa051320.34640598
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34473466
145Gastric acid secretion_Homo sapiens_hsa049710.33601189
146Oxytocin signaling pathway_Homo sapiens_hsa049210.33571197
147mTOR signaling pathway_Homo sapiens_hsa041500.33079599
148Calcium signaling pathway_Homo sapiens_hsa040200.32941352
149Renin secretion_Homo sapiens_hsa049240.31751165
150RNA polymerase_Homo sapiens_hsa030200.31079655
151Bile secretion_Homo sapiens_hsa049760.30450824
152Parkinsons disease_Homo sapiens_hsa050120.29167979
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27443431
154Peroxisome_Homo sapiens_hsa041460.26065908
155Sulfur relay system_Homo sapiens_hsa041220.23140739
156Dopaminergic synapse_Homo sapiens_hsa047280.21477752
157Vitamin digestion and absorption_Homo sapiens_hsa049770.20254304
158Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18157775

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