KLK11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.42709572
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.42172507
3epithelial cilium movement (GO:0003351)8.73956533
4motile cilium assembly (GO:0044458)8.05702903
5hemidesmosome assembly (GO:0031581)7.94695938
6keratinocyte differentiation (GO:0030216)7.86819873
7axoneme assembly (GO:0035082)7.73041365
8multicellular organismal water homeostasis (GO:0050891)7.33587752
9glucosamine-containing compound catabolic process (GO:1901072)7.06152049
10keratinocyte proliferation (GO:0043616)6.62932773
11sphingoid metabolic process (GO:0046519)6.47008409
12viral transcription (GO:0019083)6.29193677
13water homeostasis (GO:0030104)6.22926990
14long-chain fatty acid biosynthetic process (GO:0042759)6.02516757
15translational termination (GO:0006415)5.95926176
16epidermal cell differentiation (GO:0009913)5.94622047
17molting cycle (GO:0042303)5.82015246
18hair cycle (GO:0042633)5.82015246
19peptide cross-linking (GO:0018149)5.81066158
20interferon-gamma secretion (GO:0072643)5.73793014
21ribosomal small subunit biogenesis (GO:0042274)5.55707961
22regulation of cilium movement (GO:0003352)5.42677826
23regulation of phospholipase A2 activity (GO:0032429)5.42180825
24sphingosine metabolic process (GO:0006670)5.29875397
25regulation of ruffle assembly (GO:1900027)5.22476938
26epidermis development (GO:0008544)5.21801735
27bundle of His cell to Purkinje myocyte communication (GO:0086069)5.18598107
28maturation of SSU-rRNA (GO:0030490)5.04929367
29left/right pattern formation (GO:0060972)4.95179345
30regulation of chemokine secretion (GO:0090196)4.92578237
31one-carbon compound transport (GO:0019755)4.81938022
32positive regulation of interleukin-8 secretion (GO:2000484)4.79583141
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.77404087
34translational elongation (GO:0006414)4.75536497
35keratinocyte development (GO:0003334)4.74808488
36diterpenoid biosynthetic process (GO:0016102)4.71780446
37protein targeting to ER (GO:0045047)4.71453516
38diol metabolic process (GO:0034311)4.69353788
39cotranslational protein targeting to membrane (GO:0006613)4.67844735
40viral life cycle (GO:0019058)4.66263892
41prostaglandin biosynthetic process (GO:0001516)4.63210533
42prostanoid biosynthetic process (GO:0046457)4.63210533
43establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55219934
44cellular protein complex disassembly (GO:0043624)4.52714344
45intermediate filament organization (GO:0045109)4.48416770
46cilium organization (GO:0044782)4.45842206
47atrioventricular valve morphogenesis (GO:0003181)4.43697048
48protein localization to endoplasmic reticulum (GO:0070972)4.40805506
49fatty acid elongation (GO:0030497)4.36309278
50left/right axis specification (GO:0070986)4.35841538
51nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.32890853
52linoleic acid metabolic process (GO:0043651)4.31057198
53establishment of planar polarity (GO:0001736)4.25516450
54establishment of tissue polarity (GO:0007164)4.25516450
55microtubule bundle formation (GO:0001578)4.25018559
56positive regulation of chemokine secretion (GO:0090197)4.23545899
57ribosomal small subunit assembly (GO:0000028)4.22935141
58cilium assembly (GO:0042384)4.22395753
59regulation of cell proliferation involved in kidney development (GO:1901722)4.14803251
60regulation of hypersensitivity (GO:0002883)4.11201702
61regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.10685417
62cyclooxygenase pathway (GO:0019371)4.10629897
63protein localization to cilium (GO:0061512)4.03340607
64skin morphogenesis (GO:0043589)4.03188118
65phosphatidylinositol acyl-chain remodeling (GO:0036149)4.01303633
66intraciliary transport (GO:0042073)3.97164769
67regulation of interleukin-8 secretion (GO:2000482)3.91301071
68retinol metabolic process (GO:0042572)3.85163141
69terpenoid biosynthetic process (GO:0016114)3.81625432
70ectoderm development (GO:0007398)3.80643114
71translational initiation (GO:0006413)3.79016026
72lipoxygenase pathway (GO:0019372)3.76386487
73protein complex disassembly (GO:0043241)3.73793351
74cilium morphogenesis (GO:0060271)3.71728342
75ribosomal large subunit biogenesis (GO:0042273)3.69891141
76retinoic acid metabolic process (GO:0042573)3.68667161
77ethanol metabolic process (GO:0006067)3.67038108
78cardiac right ventricle morphogenesis (GO:0003215)3.66356176
79phosphatidylserine acyl-chain remodeling (GO:0036150)3.66284902
80cornea development in camera-type eye (GO:0061303)3.65180537
81prostaglandin metabolic process (GO:0006693)3.63561609
82prostanoid metabolic process (GO:0006692)3.63561609
83negative regulation of T cell differentiation in thymus (GO:0033085)3.56999735
84ventricular system development (GO:0021591)3.55443678
85lateral sprouting from an epithelium (GO:0060601)3.54540106
86negative regulation of acute inflammatory response (GO:0002674)3.50815087
87pyrimidine-containing compound transmembrane transport (GO:0072531)3.50069297
88regulation of microtubule-based movement (GO:0060632)3.49994682
89photoreceptor cell maintenance (GO:0045494)3.46278648
90macromolecular complex disassembly (GO:0032984)3.45171643
91cardiolipin metabolic process (GO:0032048)3.43946316
92amino sugar catabolic process (GO:0046348)3.39872629
93long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.38822504
94protein targeting to membrane (GO:0006612)3.38645529
95positive regulation of vesicle fusion (GO:0031340)3.35031138
96vitamin transmembrane transport (GO:0035461)3.34679527
97cellular component assembly involved in morphogenesis (GO:0010927)3.33993912
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.31751066
99behavioral response to nicotine (GO:0035095)3.31020487
100retinal cone cell development (GO:0046549)3.29682990
101negative regulation of interleukin-2 production (GO:0032703)3.29359759
102negative regulation of stress fiber assembly (GO:0051497)3.26456520
103fucose catabolic process (GO:0019317)3.25657862
104L-fucose metabolic process (GO:0042354)3.25657862
105L-fucose catabolic process (GO:0042355)3.25657862
106intestinal epithelial cell development (GO:0060576)3.25070294
107exogenous drug catabolic process (GO:0042738)3.21950890
108eyelid development in camera-type eye (GO:0061029)3.14863551
109positive regulation of interleukin-4 production (GO:0032753)3.13901357
110unsaturated fatty acid biosynthetic process (GO:0006636)3.13222759
111negative regulation of cell fate specification (GO:0009996)3.12864716
112response to pheromone (GO:0019236)3.11647669
113primary alcohol metabolic process (GO:0034308)3.07913861
114negative regulation of cell fate commitment (GO:0010454)3.06066653
115cell projection assembly (GO:0030031)3.05761066
116sperm motility (GO:0030317)3.05632573
117gland morphogenesis (GO:0022612)3.04630678
118icosanoid secretion (GO:0032309)3.03536210
119arachidonic acid secretion (GO:0050482)3.03536210
120negative regulation of kidney development (GO:0090185)3.02727550
121phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.02377913
122primary alcohol catabolic process (GO:0034310)3.01164878
123limb bud formation (GO:0060174)3.00485565
124negative regulation of interferon-gamma production (GO:0032689)3.00192916
125lung epithelium development (GO:0060428)2.99755123
126response to xenobiotic stimulus (GO:0009410)2.97157786
127detection of bacterium (GO:0016045)2.96110705
128negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.93802350
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.91953286
130rRNA catabolic process (GO:0016075)2.89745422
131intermediate filament cytoskeleton organization (GO:0045104)2.89030068
132regulation of cardioblast differentiation (GO:0051890)2.87762736
133drug catabolic process (GO:0042737)2.83707368
134heart valve morphogenesis (GO:0003179)2.83188925
135regulation of transforming growth factor beta1 production (GO:0032908)2.81920339
136fatty-acyl-CoA metabolic process (GO:0035337)2.81910276
137cellular response to interferon-alpha (GO:0035457)2.81201695
138intermediate filament-based process (GO:0045103)2.79697296
139regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.79243930
140negative regulation by host of viral transcription (GO:0043922)2.77134863
141negative regulation of T cell mediated immunity (GO:0002710)2.76797772
142phosphatidylcholine acyl-chain remodeling (GO:0036151)2.74629043
143nonmotile primary cilium assembly (GO:0035058)2.73718107
144detection of light stimulus involved in visual perception (GO:0050908)2.72153391
145detection of light stimulus involved in sensory perception (GO:0050962)2.72153391
146multicellular organism reproduction (GO:0032504)2.71819716
147thyroid hormone metabolic process (GO:0042403)2.70859312
148parturition (GO:0007567)2.67071019
149excretion (GO:0007588)2.66996039
150retinal rod cell development (GO:0046548)2.64729507
151magnesium ion transport (GO:0015693)2.64191890
152protein polyglutamylation (GO:0018095)2.58645904
153regulation of germinal center formation (GO:0002634)2.58397539
154calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57259842
155transepithelial transport (GO:0070633)2.56715932
156O-glycan processing (GO:0016266)2.53846974
157centriole assembly (GO:0098534)2.52937789
158microtubule-based movement (GO:0007018)2.51221632
159ethanol oxidation (GO:0006069)2.49418961
160thyroid hormone generation (GO:0006590)2.47223052
161glutathione derivative biosynthetic process (GO:1901687)2.41298338
162glutathione derivative metabolic process (GO:1901685)2.41298338
163GPI anchor metabolic process (GO:0006505)2.39220546
164nucleoside diphosphate phosphorylation (GO:0006165)2.38731485
165cellular ketone body metabolic process (GO:0046950)2.33983551
166regulation of collateral sprouting (GO:0048670)2.32840457
167retinal metabolic process (GO:0042574)2.32686881
168regulation of neuron projection regeneration (GO:0070570)2.32096187
169desmosome organization (GO:0002934)13.7657931
170axonemal dynein complex assembly (GO:0070286)11.7925592
171keratinization (GO:0031424)11.7435101
172establishment of skin barrier (GO:0061436)11.7218259
173regulation of water loss via skin (GO:0033561)10.7405418
174cilium or flagellum-dependent cell motility (GO:0001539)10.3442110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.70449612
2VDR_22108803_ChIP-Seq_LS180_Human3.38630693
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.09772628
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.84753420
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.79503270
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.70388709
7ZNF274_21170338_ChIP-Seq_K562_Hela2.53462372
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.50373550
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48545258
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.35485856
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.09166724
12ZNF263_19887448_ChIP-Seq_K562_Human2.08791285
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07910437
14TP63_17297297_ChIP-ChIP_HaCaT_Human17.1348117
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.98719270
16SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95153268
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95153268
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87593730
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86765611
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.80796331
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78483320
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.75731808
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66027660
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59979257
25DROSHA_22980978_ChIP-Seq_HELA_Human1.58710716
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56391768
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55010390
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54246845
29FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52772158
30FOXA1_25329375_ChIP-Seq_VCAP_Human1.52772158
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50806860
32ER_23166858_ChIP-Seq_MCF-7_Human1.46920228
33AR_20517297_ChIP-Seq_VCAP_Human1.44388530
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43827166
35GBX2_23144817_ChIP-Seq_PC3_Human1.41724246
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40856414
37* SOX2_20726797_ChIP-Seq_SW620_Human1.38847283
38CJUN_26792858_Chip-Seq_BT549_Human1.37343101
39EZH2_22144423_ChIP-Seq_EOC_Human1.36779174
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36748449
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.36215218
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35803765
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34086324
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.33410981
45SMAD4_21799915_ChIP-Seq_A2780_Human1.32863436
46TP63_23658742_ChIP-Seq_EP156T_Human1.32551217
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.31969316
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30209734
49AR_21572438_ChIP-Seq_LNCaP_Human1.29316135
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.29230038
51NCOR_22424771_ChIP-Seq_293T_Human1.27805025
52ETV1_20927104_ChIP-Seq_GIST48_Human1.27773819
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27324367
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27128269
55IGF1R_20145208_ChIP-Seq_DFB_Human1.26968478
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26234402
57CBP_20019798_ChIP-Seq_JUKART_Human1.24750824
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24750824
59FUS_26573619_Chip-Seq_HEK293_Human1.24221840
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23758120
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23256057
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22757174
63P300_19829295_ChIP-Seq_ESCs_Human1.22155882
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21964700
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20827361
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20204846
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.20059789
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19690387
69ERG_20517297_ChIP-Seq_VCAP_Human1.19608758
70TP63_22573176_ChIP-Seq_HFKS_Human1.19546153
71AR_25329375_ChIP-Seq_VCAP_Human1.19256128
72HOXB7_26014856_ChIP-Seq_BT474_Human1.18652876
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.17602307
74TCF4_23295773_ChIP-Seq_U87_Human1.15838037
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15728334
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15437515
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15205327
78* MYC_19829295_ChIP-Seq_ESCs_Human1.14730692
79TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14364136
80TAF2_19829295_ChIP-Seq_ESCs_Human1.13700668
81STAT3_23295773_ChIP-Seq_U87_Human1.13358803
82TAF15_26573619_Chip-Seq_HEK293_Human1.13322582
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13167177
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13167177
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.12857274
86* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12131658
87CDX2_22108803_ChIP-Seq_LS180_Human1.12129779
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11825989
89KLF5_25053715_ChIP-Seq_YYC3_Human1.11617836
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.10680766
91EWS_26573619_Chip-Seq_HEK293_Human1.08151095
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07805853
93FOXH1_21741376_ChIP-Seq_ESCs_Human1.07361689
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.07099833
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06834036
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.06685393
97GATA6_21074721_ChIP-Seq_CACO-2_Human1.06678625
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05700814
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05689589
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05415408
101CDX2_20551321_ChIP-Seq_CACO-2_Human1.05034332
102STAT1_20625510_ChIP-Seq_HELA_Human1.04692308
103NANOG_19829295_ChIP-Seq_ESCs_Human1.03548312
104SOX2_19829295_ChIP-Seq_ESCs_Human1.03548312
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03380131
106CBX2_22325352_ChIP-Seq_293T-Rex_Human1.02994088
107TP53_18474530_ChIP-ChIP_U2OS_Human1.02796499
108RUNX2_22187159_ChIP-Seq_PCA_Human1.01796471
109* ERA_21632823_ChIP-Seq_H3396_Human1.01750603
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00524483
111TBL1_22424771_ChIP-Seq_293T_Human1.00361157
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.98790659
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98582965
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97796391
115RXR_22108803_ChIP-Seq_LS180_Human0.94930417
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93579520
117CEBPB_22108803_ChIP-Seq_LS180_Human0.92813565
118ATF3_27146783_Chip-Seq_COLON_Human0.92449757
119RACK7_27058665_Chip-Seq_MCF-7_Human0.91155401
120UBF1/2_26484160_Chip-Seq_HMECs_Human0.89571000
121AHR_22903824_ChIP-Seq_MCF-7_Human0.88633387
122GATA4_25053715_ChIP-Seq_YYC3_Human0.87211915
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86450308
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86450256
125SA1_27219007_Chip-Seq_ERYTHROID_Human0.84967148
126CTCF_27219007_Chip-Seq_Bcells_Human0.84417683
127GATA6_25053715_ChIP-Seq_YYC3_Human0.81569186
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81283793
129CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.78821528
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77887224
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77784233
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.75290833
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74957694
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.74654770
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71878514
136BCAT_22108803_ChIP-Seq_LS180_Human0.71823555
137TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71403599
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71012943
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.70813994
140TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68576188
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.68526616
142GATA1_22025678_ChIP-Seq_K562_Human0.68282056
143SA1_27219007_Chip-Seq_Bcells_Human0.67175144
144NANOG_18692474_ChIP-Seq_MEFs_Mouse0.67125932
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.66538343
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.66273251
147EED_16625203_ChIP-ChIP_MESCs_Mouse0.66262517
148HNFA_21074721_ChIP-Seq_CACO-2_Human0.65846170
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.64968276
150LXR_22292898_ChIP-Seq_THP-1_Human0.64939006
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64811668
152RBPJ_21746931_ChIP-Seq_IB4_Human0.64145053
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.63752454
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.62728337
155TCF4_22108803_ChIP-Seq_LS180_Human0.62014093
156NANOG_20526341_ChIP-Seq_ESCs_Human0.61969785
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61421575
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.60073965
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.60054124
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.59596882
161EZH2_27294783_Chip-Seq_ESCs_Mouse0.59022109
162SOX2_27498859_Chip-Seq_STOMACH_Mouse0.58901560
163CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.58819208
164PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.58309298
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58194717
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.57813457
167ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.56609214
168CSB_26484114_Chip-Seq_FIBROBLAST_Human0.55547979
169PHF8_20622853_ChIP-Seq_HELA_Human0.55457339
170KDM2B_26808549_Chip-Seq_K562_Human0.54320142
171CTCF_20526341_ChIP-Seq_ESCs_Human0.53793545
172SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.53512337
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.53427557

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.00561019
2MP0005275_abnormal_skin_tensile5.19053330
3MP0003941_abnormal_skin_development4.91335952
4MP0005501_abnormal_skin_physiology4.83649361
5MP0010234_abnormal_vibrissa_follicle4.81480500
6MP0004381_abnormal_hair_follicle4.14448669
7MP0002254_reproductive_system_inflammat4.01940147
8MP0004043_abnormal_pH_regulation3.91823143
9MP0008875_abnormal_xenobiotic_pharmacok3.75024909
10MP0002060_abnormal_skin_morphology3.63895681
11MP0001216_abnormal_epidermal_layer3.61968042
12MP0005377_hearing/vestibular/ear_phenot3.52428007
13MP0003878_abnormal_ear_physiology3.52428007
14MP0000383_abnormal_hair_follicle3.45322360
15MP0010771_integument_phenotype3.19418834
16MP0000579_abnormal_nail_morphology3.14641886
17MP0010678_abnormal_skin_adnexa3.14086910
18MP0003453_abnormal_keratinocyte_physiol3.02941712
19MP0000467_abnormal_esophagus_morphology2.94346012
20MP0002098_abnormal_vibrissa_morphology2.89481622
21MP0002653_abnormal_ependyma_morphology2.82252082
22MP0000647_abnormal_sebaceous_gland2.73498729
23MP0004885_abnormal_endolymph2.71607935
24MP0005451_abnormal_body_composition2.62156669
25MP0004947_skin_inflammation2.45657697
26MP0009379_abnormal_foot_pigmentation2.38919946
27MP0000566_synostosis2.26575951
28MP0000377_abnormal_hair_follicle2.24503108
29MP0001346_abnormal_lacrimal_gland2.22822175
30MP0009780_abnormal_chondrocyte_physiolo2.13246203
31MP0000427_abnormal_hair_cycle2.09163678
32MP0000762_abnormal_tongue_morphology1.98014403
33MP0003566_abnormal_cell_adhesion1.90865951
34MP0008789_abnormal_olfactory_epithelium1.89277651
35MP0004185_abnormal_adipocyte_glucose1.87945967
36MP0001191_abnormal_skin_condition1.78582189
37MP0009931_abnormal_skin_appearance1.78282741
38MP0005551_abnormal_eye_electrophysiolog1.74307942
39MP0003705_abnormal_hypodermis_morpholog1.63988882
40MP0001485_abnormal_pinna_reflex1.63975136
41MP0001188_hyperpigmentation1.47997679
42MP0004133_heterotaxia1.45317295
43MP0008872_abnormal_physiological_respon1.44739734
44MP0002009_preneoplasia1.41763356
45MP0001243_abnormal_dermal_layer1.38750086
46MP0003136_yellow_coat_color1.37726872
47MP0008004_abnormal_stomach_pH1.37713513
48MP0000367_abnormal_coat/_hair1.36373621
49MP0006072_abnormal_retinal_apoptosis1.36114938
50MP0001765_abnormal_ion_homeostasis1.30291948
51MP0001851_eye_inflammation1.29957194
52MP0005253_abnormal_eye_physiology1.24153817
53MP0002876_abnormal_thyroid_physiology1.21876401
54MP0005174_abnormal_tail_pigmentation1.19145670
55MP0005499_abnormal_olfactory_system1.14426543
56MP0005394_taste/olfaction_phenotype1.14426543
57MP0010352_gastrointestinal_tract_polyps1.14038764
58MP0005646_abnormal_pituitary_gland1.13269206
59MP0005023_abnormal_wound_healing1.10157378
60MP0002160_abnormal_reproductive_system1.09599383
61MP0001340_abnormal_eyelid_morphology1.05634842
62MP0002638_abnormal_pupillary_reflex1.01173056
63MP0005389_reproductive_system_phenotype1.00362334
64MP0002877_abnormal_melanocyte_morpholog1.00095992
65MP0004782_abnormal_surfactant_physiolog0.98151304
66MP0002138_abnormal_hepatobiliary_system0.96693366
67MP0009046_muscle_twitch0.96009785
68MP0002102_abnormal_ear_morphology0.93191046
69MP0003011_delayed_dark_adaptation0.91154633
70MP0005083_abnormal_biliary_tract0.90269216
71MP0003646_muscle_fatigue0.89447900
72MP0000631_abnormal_neuroendocrine_gland0.87719349
73MP0005076_abnormal_cell_differentiation0.85741658
74MP0000627_abnormal_mammary_gland0.85630637
75MP0001502_abnormal_circadian_rhythm0.85443728
76MP0000026_abnormal_inner_ear0.85316657
77MP0003191_abnormal_cellular_cholesterol0.84891740
78MP0002234_abnormal_pharynx_morphology0.83790594
79MP0002837_dystrophic_cardiac_calcinosis0.82598093
80MP0002909_abnormal_adrenal_gland0.81767067
81MP0005636_abnormal_mineral_homeostasis0.79586063
82MP0002277_abnormal_respiratory_mucosa0.79269473
83MP0004264_abnormal_extraembryonic_tissu0.77194198
84MP0009053_abnormal_anal_canal0.76187073
85MP0003436_decreased_susceptibility_to0.75109377
86MP0000372_irregular_coat_pigmentation0.74297127
87MP0002282_abnormal_trachea_morphology0.74106552
88MP0002928_abnormal_bile_duct0.74002029
89MP0001968_abnormal_touch/_nociception0.73681174
90MP0001501_abnormal_sleep_pattern0.73102468
91MP0005195_abnormal_posterior_eye0.72617665
92MP0010386_abnormal_urinary_bladder0.71660033
93MP0000465_gastrointestinal_hemorrhage0.70275030
94MP0005365_abnormal_bile_salt0.69521342
95MP0010030_abnormal_orbit_morphology0.69036899
96MP0001756_abnormal_urination0.68407584
97MP0001984_abnormal_olfaction0.66355744
98MP0001919_abnormal_reproductive_system0.64877526
99MP0005645_abnormal_hypothalamus_physiol0.64708982
100MP0002735_abnormal_chemical_nociception0.64220623
101MP0001970_abnormal_pain_threshold0.63093683
102MP0009745_abnormal_behavioral_response0.62590694
103MP0002233_abnormal_nose_morphology0.62471797
104MP0002557_abnormal_social/conspecific_i0.62318438
105MP0002272_abnormal_nervous_system0.61479335
106MP0003698_abnormal_male_reproductive0.60956314
107MP0001664_abnormal_digestion0.60944922
108MP0005410_abnormal_fertilization0.60874446
109MP0009384_cardiac_valve_regurgitation0.60799669
110MP0002938_white_spotting0.59534450
111MP0002736_abnormal_nociception_after0.59502990
112MP0002229_neurodegeneration0.59326392
113MP0002111_abnormal_tail_morphology0.59130234
114MP0005666_abnormal_adipose_tissue0.58638207
115MP0003638_abnormal_response/metabolism_0.57919494
116MP0001784_abnormal_fluid_regulation0.57774307
117MP0005409_darkened_coat_color0.56294135
118MP0003755_abnormal_palate_morphology0.54811546
119MP0002177_abnormal_outer_ear0.53394327
120MP0003385_abnormal_body_wall0.52401059
121MP0001849_ear_inflammation0.52338347
122MP0002006_tumorigenesis0.51881521
123MP0002249_abnormal_larynx_morphology0.51845971
124MP0002095_abnormal_skin_pigmentation0.51826671
125MP0009250_abnormal_appendicular_skeleto0.51728529
126MP0005257_abnormal_intraocular_pressure0.48363293
127MP0005508_abnormal_skeleton_morphology0.47942338
128MP0000538_abnormal_urinary_bladder0.46819451
129MP0000470_abnormal_stomach_morphology0.46618358
130MP0003950_abnormal_plasma_membrane0.46341816
131MP0004019_abnormal_vitamin_homeostasis0.46114635
132MP0002148_abnormal_hypersensitivity_rea0.45638411
133MP0000613_abnormal_salivary_gland0.39881801
134MP0002166_altered_tumor_susceptibility0.38942588
135MP0001666_abnormal_nutrient_absorption0.37759260
136MP0003195_calcinosis0.37337897
137MP0001542_abnormal_bone_strength0.34251830
138MP0005390_skeleton_phenotype0.34146688
139MP0003315_abnormal_perineum_morphology0.32816931
140MP0003718_maternal_effect0.32176519
141MP0004272_abnormal_basement_membrane0.31694663
142MP0005248_abnormal_Harderian_gland0.31373720
143MP0002132_abnormal_respiratory_system0.30067499
144MP0000432_abnormal_head_morphology0.29659768
145MP0003938_abnormal_ear_development0.28796949
146MP0001533_abnormal_skeleton_physiology0.28445518
147MP0005647_abnormal_sex_gland0.28251855
148MP0002109_abnormal_limb_morphology0.27434562
149MP0008961_abnormal_basal_metabolism0.26491000
150MP0005375_adipose_tissue_phenotype0.26267257
151MP0003936_abnormal_reproductive_system0.25572540
152MP0000750_abnormal_muscle_regeneration0.24552140
153MP0005075_abnormal_melanosome_morpholog0.24318985
154MP0005408_hypopigmentation0.22808634
155MP0003763_abnormal_thymus_physiology0.22126105
156MP0005165_increased_susceptibility_to0.21438706
157MP0002163_abnormal_gland_morphology0.21035522
158MP0000163_abnormal_cartilage_morphology0.20852289

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.19327495
2Absent/shortened dynein arms (HP:0200106)8.19327495
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.01609348
4Abnormal respiratory motile cilium morphology (HP:0005938)7.72313590
5Abnormal respiratory epithelium morphology (HP:0012253)7.72313590
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.70008469
7Abnormal ciliary motility (HP:0012262)7.29380626
8Abnormal respiratory motile cilium physiology (HP:0012261)7.25577424
9Congenital ichthyosiform erythroderma (HP:0007431)7.09506347
10Hypotrichosis (HP:0001006)6.68942031
11Rhinitis (HP:0012384)6.40973776
12Plantar hyperkeratosis (HP:0007556)6.26456683
13Chronic bronchitis (HP:0004469)5.93784785
14Woolly hair (HP:0002224)5.89374324
15Parakeratosis (HP:0001036)5.74312518
16Palmoplantar hyperkeratosis (HP:0000972)5.68508202
17Increased IgE level (HP:0003212)5.54723122
18Abnormality of nail color (HP:0100643)5.50620476
19Lip pit (HP:0100267)5.45825909
20Erythema (HP:0010783)5.37188188
21Fragile nails (HP:0001808)5.35728570
22Palmar hyperkeratosis (HP:0010765)5.34142129
23Right ventricular cardiomyopathy (HP:0011663)5.31006916
24Erythroderma (HP:0001019)5.13802094
25Bronchiectasis (HP:0002110)4.92268335
26Onycholysis (HP:0001806)4.87696472
27Conjunctival hamartoma (HP:0100780)4.55838499
28Milia (HP:0001056)4.44630636
29Ectropion (HP:0000656)4.34094431
30Thick nail (HP:0001805)4.29341399
31Abnormal blistering of the skin (HP:0008066)4.05337239
32Corneal erosion (HP:0200020)4.00594200
33Pancreatic fibrosis (HP:0100732)3.86473553
34Hypohidrosis (HP:0000966)3.84701148
35Pancreatic cysts (HP:0001737)3.81817901
36True hermaphroditism (HP:0010459)3.80015416
37Nasal polyposis (HP:0100582)3.77287179
38Abnormality of the axillary hair (HP:0100134)3.76038015
39Abnormality of secondary sexual hair (HP:0009888)3.76038015
40Distal lower limb muscle weakness (HP:0009053)3.70675629
41Gangrene (HP:0100758)3.67889549
42Molar tooth sign on MRI (HP:0002419)3.66693597
43Abnormality of midbrain morphology (HP:0002418)3.66693597
44Abnormality of cells of the erythroid lineage (HP:0012130)3.64336615
45Pili torti (HP:0003777)3.60140379
46Nephronophthisis (HP:0000090)3.54402948
47Abnormal hemoglobin (HP:0011902)3.50618222
48Nail dystrophy (HP:0008404)3.47051403
49Popliteal pterygium (HP:0009756)3.42448330
50Reticulocytopenia (HP:0001896)3.34651335
51Hyporeflexia of lower limbs (HP:0002600)3.34233142
52Furrowed tongue (HP:0000221)3.32225487
53Chronic hepatic failure (HP:0100626)3.28140423
54Pruritus (HP:0000989)3.20358491
55Sparse eyelashes (HP:0000653)3.18709572
56Hyperactive renin-angiotensin system (HP:0000841)3.14507662
57Palmoplantar keratoderma (HP:0000982)3.12842896
58Abnormality of the renal medulla (HP:0100957)3.11876087
59Cystic liver disease (HP:0006706)3.06786049
60Bronchitis (HP:0012387)3.00538699
61Concave nail (HP:0001598)2.92101128
62Abnormality of the nasal mucosa (HP:0000433)2.90775535
63Decreased circulating renin level (HP:0003351)2.90390583
64Natal tooth (HP:0000695)2.88740060
65Abnormal number of erythroid precursors (HP:0012131)2.86310888
66Ventricular tachycardia (HP:0004756)2.83390029
67Advanced eruption of teeth (HP:0006288)2.82511626
68Congenital, generalized hypertrichosis (HP:0004540)2.80275077
69Atrophic scars (HP:0001075)2.77676469
70Sparse scalp hair (HP:0002209)2.76726022
71Abnormality of the salivary glands (HP:0010286)2.74024206
72Curly hair (HP:0002212)2.70613029
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69683932
74Tubular atrophy (HP:0000092)2.69681725
75Chronic sinusitis (HP:0011109)2.69226406
76Acanthosis nigricans (HP:0000956)2.66045861
77Ridged nail (HP:0001807)2.61811881
78Occipital encephalocele (HP:0002085)2.61155106
79Tubulointerstitial nephritis (HP:0001970)2.60535079
80Hamartoma of the eye (HP:0010568)2.60497235
81Recurrent sinusitis (HP:0011108)2.58146836
82Infertility (HP:0000789)2.56784902
83Alopecia of scalp (HP:0002293)2.55202732
84Macrocytic anemia (HP:0001972)2.51888941
85Abnormal hair laboratory examination (HP:0003328)2.46839170
86Abnormal rod and cone electroretinograms (HP:0008323)2.46663700
87Pterygium (HP:0001059)2.44865718
88Medial flaring of the eyebrow (HP:0010747)2.42899756
89Areflexia of lower limbs (HP:0002522)2.36713590
90Hypoplastic labia majora (HP:0000059)2.34081223
91Abnormality of the renal cortex (HP:0011035)2.30847912
92Aplasia cutis congenita (HP:0001057)2.25012156
93Congenital hepatic fibrosis (HP:0002612)2.24551497
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.22699238
95Renal salt wasting (HP:0000127)2.20956156
96Conical tooth (HP:0000698)2.17310454
97Postaxial foot polydactyly (HP:0001830)2.16877136
98Severe Myopia (HP:0011003)2.15462794
99Recurrent otitis media (HP:0000403)2.15291863
100Abnormality of the labia majora (HP:0012881)2.11915435
101Hyperkalemia (HP:0002153)2.11308748
102Anhidrosis (HP:0000970)2.11119691
103Dry skin (HP:0000958)2.10880581
104Pallor (HP:0000980)2.09095048
105Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06024677
106Increased connective tissue (HP:0009025)2.05920714
107Stenosis of the external auditory canal (HP:0000402)2.04746981
108Abnormality of the distal phalanges of the toes (HP:0010182)2.00793831
109Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.99775610
110Male pseudohermaphroditism (HP:0000037)1.99402821
111Lack of skin elasticity (HP:0100679)1.99000000
112Anencephaly (HP:0002323)1.98571351
113Abnormality of renin-angiotensin system (HP:0000847)1.98390221
114Abnormality of the 2nd finger (HP:0004100)1.98169262
115Hyperaldosteronism (HP:0000859)1.96615015
116Down-sloping shoulders (HP:0200021)1.95562881
117Sclerocornea (HP:0000647)1.95079745
118Paralysis (HP:0003470)1.92318182
119Dehydration (HP:0001944)1.92290260
120Brittle hair (HP:0002299)1.91083327
121Blepharitis (HP:0000498)1.89612836
122Septate vagina (HP:0001153)1.89305104
123Trismus (HP:0000211)1.88593399
124Congenital stationary night blindness (HP:0007642)1.84796787
125Aplasia involving bones of the upper limbs (HP:0009823)1.83238877
126Aplasia of the phalanges of the hand (HP:0009802)1.83238877
127Aplasia involving bones of the extremities (HP:0009825)1.83238877
128Hypodontia (HP:0000668)1.82062817
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.82048037
130Congenital primary aphakia (HP:0007707)1.79566000
131Gait imbalance (HP:0002141)1.79240110
132Polydipsia (HP:0001959)1.78931478
133Abnormal drinking behavior (HP:0030082)1.78931478
134Oligodontia (HP:0000677)1.78103423
135Hypoplasia of dental enamel (HP:0006297)1.76163456
136Ulnar claw (HP:0001178)1.75285307
137Anonychia (HP:0001798)1.74981712
138Hypoplasia of the uterus (HP:0000013)1.74945622
139Male infertility (HP:0003251)1.74900300
140Asplenia (HP:0001746)1.74536976
141Chronic otitis media (HP:0000389)1.73716552
142Absent hair (HP:0002298)1.72959695
143Abnormality of chloride homeostasis (HP:0011422)1.71424734
144Abnormality of the gastric mucosa (HP:0004295)1.68901633
145Tubulointerstitial abnormality (HP:0001969)1.68540638
146Hypergammaglobulinemia (HP:0010702)1.68283338
147Absent eyebrow (HP:0002223)1.67739551
148Aplasia/hypoplasia of the uterus (HP:0008684)1.67333485
149Hypokalemic alkalosis (HP:0001949)1.66637955
150Abnormality of the middle phalanges of the toes (HP:0010183)1.65833474
151Decreased central vision (HP:0007663)1.65583802
152Fragile skin (HP:0001030)1.64263688
153Pendular nystagmus (HP:0012043)1.64260125
154Oral leukoplakia (HP:0002745)1.64249485
155Malignant hyperthermia (HP:0002047)1.63786433
156Abnormality of the phalanges of the 5th finger (HP:0004213)1.63010723
157Type I diabetes mellitus (HP:0100651)1.62892939
158Hypoparathyroidism (HP:0000829)1.62606526
159Skin ulcer (HP:0200042)1.60597677
160Fatigable weakness (HP:0003473)1.60165867
161Abnormality of the neuromuscular junction (HP:0003398)1.60165867
162Nephrogenic diabetes insipidus (HP:0009806)1.59649433
163Abnormality of macular pigmentation (HP:0008002)1.59284085
164Bony spicule pigmentary retinopathy (HP:0007737)1.58957859
165Pustule (HP:0200039)1.57979127
166Esophageal atresia (HP:0002032)1.57250112
167Postaxial hand polydactyly (HP:0001162)1.55893750
168Abnormality of the renal collecting system (HP:0004742)1.53036349
169Median cleft lip (HP:0000161)1.52625078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K35.91526356
2MST1R5.16621313
3MAPKAPK35.02938249
4MST44.72757392
5MAP3K23.19012417
6FER2.98485195
7STK242.90460787
8PIM22.84843734
9BMPR1B2.82866127
10RPS6KB22.66927200
11WNK42.42388051
12STK392.35986254
13TAOK32.24424241
14TRPM72.17564217
15TGFBR12.14576220
16MAP4K22.13575613
17EPHA22.08156111
18INSRR2.03695321
19MET2.01719900
20ADRBK22.01266016
21TLK11.98553374
22ERBB31.95296540
23LRRK21.84594979
24ERN11.68591405
25PIK3CG1.63744892
26ZAK1.62732758
27MAP2K61.59556681
28PINK11.57396481
29BLK1.53816993
30WNK31.52486113
31STK101.52131548
32MAP3K41.39314517
33MAPKAPK51.38647557
34FGFR21.37742470
35STK161.25569575
36TESK11.22097822
37OXSR11.21642916
38MUSK1.16752683
39TAOK11.14804707
40NTRK21.13287930
41TXK1.13269666
42NME21.12259358
43EEF2K1.11248252
44EPHB21.09278781
45RPS6KA41.02350923
46FGFR41.02054385
47MAP3K141.01668770
48TTN1.00654186
49LATS10.98163260
50IRAK10.96476865
51MAPK130.95595831
52NLK0.94430306
53GRK10.93309347
54SIK10.88629008
55MAP3K10.87829122
56LMTK20.86502212
57NUAK10.86376567
58MAP2K30.85188683
59PHKG10.84043045
60PHKG20.84043045
61PTK60.83433715
62BMPR20.83083873
63LIMK10.82658625
64MAPKAPK20.81307893
65ILK0.80832447
66BCR0.80301334
67EPHA30.79653400
68ACVR1B0.79643520
69TRIB30.79403277
70GRK70.78771122
71TGFBR20.78682889
72PTK2B0.77921235
73IKBKB0.75867703
74CDK190.73258334
75DYRK1B0.72273708
76TYK20.72071001
77CDK60.70900915
78PRKCQ0.68601515
79PAK30.65509039
80FGFR30.64917962
81MAPK150.62845531
82GRK60.62711213
83OBSCN0.62469825
84ADRBK10.62301618
85MAP3K110.61707147
86CDK30.61605675
87EIF2AK20.60205143
88PRKCI0.59001763
89FRK0.57672305
90ITK0.54300164
91PRKAA20.53556247
92IRAK40.52977843
93PRKCG0.52597931
94CHUK0.52020125
95BRAF0.51403446
96SGK4940.47016484
97SGK2230.47016484
98NME10.45605758
99EPHA40.44999817
100BRSK20.43992448
101FGFR10.43268583
102MAP2K10.42183659
103PRKACA0.41556665
104STK110.41404149
105ROCK20.41121795
106PRKD10.40874401
107MAP2K70.40736564
108DDR20.39970210
109PRKCD0.39468369
110AKT30.39397560
111PRKCE0.38562712
112PTK20.38400706
113TNK20.37489550
114CSNK1D0.37458452
115SGK10.36931633
116VRK10.36688983
117TRIM280.36160147
118RIPK10.35823218
119CDK80.35701032
120PRKCZ0.35210502
121HIPK20.34086507
122WNK10.33776385
123STK30.33769209
124MAPK40.33600068
125CAMK2A0.33450391
126KIT0.33248829
127MAP2K20.32165861
128CAMK10.31860837
129SGK20.31756458
130CASK0.31624600
131ROCK10.31551225
132IGF1R0.30964662
133STK380.30706919
134STK38L0.30636647
135PNCK0.30525817
136CSNK1A10.29141945
137MOS0.28579490
138ABL20.28301579
139TIE10.28293276
140DYRK20.27816870
141TTK0.27091136
142PRKCH0.27054773
143DAPK20.26961971
144MAP3K70.26810250
145MAP3K60.25969801
146MAPK120.25860752
147GRK50.25373134
148RPS6KA10.25006305
149MAP3K50.24970969
150DYRK1A0.24290771
151SIK30.23795274
152GSK3A0.23727839
153IKBKE0.22533237
154ERBB20.22462161
155RPS6KC10.20286910
156RPS6KL10.20286910
157RPS6KA20.20229623
158DMPK0.19699068
159HCK0.18643189
160SRC0.18602694
161PRKCA0.17962090
162EPHB10.17600371

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.86847853
2Ribosome_Homo sapiens_hsa030105.55763201
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.54225133
4Linoleic acid metabolism_Homo sapiens_hsa005913.52654779
5Arachidonic acid metabolism_Homo sapiens_hsa005903.46402203
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.43536349
7Sphingolipid metabolism_Homo sapiens_hsa006003.21149242
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.92999542
9Phenylalanine metabolism_Homo sapiens_hsa003602.42232397
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23365884
11Histidine metabolism_Homo sapiens_hsa003402.10458034
12Fatty acid elongation_Homo sapiens_hsa000622.00513379
13Ether lipid metabolism_Homo sapiens_hsa005652.00425928
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92965300
15Nitrogen metabolism_Homo sapiens_hsa009101.87591513
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.77958562
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74522852
18Basal cell carcinoma_Homo sapiens_hsa052171.69306259
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60388696
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56251950
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55834503
22Huntingtons disease_Homo sapiens_hsa050161.55574790
23ECM-receptor interaction_Homo sapiens_hsa045121.50448427
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44615346
25Retinol metabolism_Homo sapiens_hsa008301.42506873
26VEGF signaling pathway_Homo sapiens_hsa043701.41025772
27Chemical carcinogenesis_Homo sapiens_hsa052041.35334104
28Hedgehog signaling pathway_Homo sapiens_hsa043401.33071933
29Butanoate metabolism_Homo sapiens_hsa006501.25062036
30Tyrosine metabolism_Homo sapiens_hsa003501.24592609
31Tryptophan metabolism_Homo sapiens_hsa003801.24524961
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.19488458
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18931453
34Protein export_Homo sapiens_hsa030601.18451267
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17949845
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16048782
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14337841
38Staphylococcus aureus infection_Homo sapiens_hsa051501.13796989
39p53 signaling pathway_Homo sapiens_hsa041151.09351579
40Renin secretion_Homo sapiens_hsa049241.07042926
41Nicotine addiction_Homo sapiens_hsa050331.05102199
42Serotonergic synapse_Homo sapiens_hsa047261.04626617
43Pancreatic secretion_Homo sapiens_hsa049721.04413760
44GnRH signaling pathway_Homo sapiens_hsa049121.03119715
45Olfactory transduction_Homo sapiens_hsa047401.02794165
46Tight junction_Homo sapiens_hsa045301.02406571
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01270883
48Axon guidance_Homo sapiens_hsa043601.00320138
49Peroxisome_Homo sapiens_hsa041460.98923818
50Hippo signaling pathway_Homo sapiens_hsa043900.97585301
51Circadian rhythm_Homo sapiens_hsa047100.97042546
52Sulfur metabolism_Homo sapiens_hsa009200.96629411
53Ovarian steroidogenesis_Homo sapiens_hsa049130.96077442
54Fat digestion and absorption_Homo sapiens_hsa049750.91722619
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91507697
56Bladder cancer_Homo sapiens_hsa052190.91230928
57Proteoglycans in cancer_Homo sapiens_hsa052050.90657263
58Adherens junction_Homo sapiens_hsa045200.86181532
59Regulation of autophagy_Homo sapiens_hsa041400.85417509
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83810179
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.83025105
62Glutathione metabolism_Homo sapiens_hsa004800.81319454
63Long-term depression_Homo sapiens_hsa047300.79193044
64Glycerolipid metabolism_Homo sapiens_hsa005610.78665636
65Melanogenesis_Homo sapiens_hsa049160.77654514
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.77170771
67beta-Alanine metabolism_Homo sapiens_hsa004100.74941607
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73839234
69Protein digestion and absorption_Homo sapiens_hsa049740.73709709
70Salivary secretion_Homo sapiens_hsa049700.73051890
71Amoebiasis_Homo sapiens_hsa051460.72967744
72Phototransduction_Homo sapiens_hsa047440.70872821
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69287267
74Ras signaling pathway_Homo sapiens_hsa040140.68625037
75Fatty acid degradation_Homo sapiens_hsa000710.67721934
76Platelet activation_Homo sapiens_hsa046110.67713223
77Cardiac muscle contraction_Homo sapiens_hsa042600.65987420
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65464007
79Parkinsons disease_Homo sapiens_hsa050120.64821461
80Basal transcription factors_Homo sapiens_hsa030220.63851059
81MicroRNAs in cancer_Homo sapiens_hsa052060.63681883
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.63564809
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.62312804
84Vitamin digestion and absorption_Homo sapiens_hsa049770.61627215
85Alzheimers disease_Homo sapiens_hsa050100.60127255
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59512454
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58630980
88Selenocompound metabolism_Homo sapiens_hsa004500.57372497
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57256626
90Pertussis_Homo sapiens_hsa051330.57244240
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56572107
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55064110
93Metabolic pathways_Homo sapiens_hsa011000.55005840
94Glutamatergic synapse_Homo sapiens_hsa047240.54336777
95Insulin secretion_Homo sapiens_hsa049110.54115698
96Mineral absorption_Homo sapiens_hsa049780.53275461
97Toxoplasmosis_Homo sapiens_hsa051450.53036863
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.52199921
99Graft-versus-host disease_Homo sapiens_hsa053320.51826403
100TGF-beta signaling pathway_Homo sapiens_hsa043500.51650788
101Hepatitis C_Homo sapiens_hsa051600.51227168
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50797156
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48021542
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47666917
105Fatty acid biosynthesis_Homo sapiens_hsa000610.47581615
106Thyroid cancer_Homo sapiens_hsa052160.46087141
107Caffeine metabolism_Homo sapiens_hsa002320.45329734
108ABC transporters_Homo sapiens_hsa020100.44823720
109Starch and sucrose metabolism_Homo sapiens_hsa005000.44509934
110Type I diabetes mellitus_Homo sapiens_hsa049400.44241652
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.43922010
112Circadian entrainment_Homo sapiens_hsa047130.42866749
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.40146150
114Small cell lung cancer_Homo sapiens_hsa052220.39726439
115Rap1 signaling pathway_Homo sapiens_hsa040150.38028240
116Gastric acid secretion_Homo sapiens_hsa049710.37576933
117ErbB signaling pathway_Homo sapiens_hsa040120.36239214
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35063594
119Wnt signaling pathway_Homo sapiens_hsa043100.33775597
120Dorso-ventral axis formation_Homo sapiens_hsa043200.33031993
121Propanoate metabolism_Homo sapiens_hsa006400.32694342
122Calcium signaling pathway_Homo sapiens_hsa040200.32674872
123Salmonella infection_Homo sapiens_hsa051320.32351413
124Steroid biosynthesis_Homo sapiens_hsa001000.31774313
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31743227
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29630253
127Collecting duct acid secretion_Homo sapiens_hsa049660.27874483
128Arginine and proline metabolism_Homo sapiens_hsa003300.27525342
129Asthma_Homo sapiens_hsa053100.27521179
130Oxytocin signaling pathway_Homo sapiens_hsa049210.27498459
131Homologous recombination_Homo sapiens_hsa034400.26926053
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.26101260
133cAMP signaling pathway_Homo sapiens_hsa040240.25468226
134Focal adhesion_Homo sapiens_hsa045100.24434889
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23936834
136Primary bile acid biosynthesis_Homo sapiens_hsa001200.22964071
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21826395
138Morphine addiction_Homo sapiens_hsa050320.21791699
139TNF signaling pathway_Homo sapiens_hsa046680.20278276
140Pathways in cancer_Homo sapiens_hsa052000.19599466
141Melanoma_Homo sapiens_hsa052180.18426309
142Oxidative phosphorylation_Homo sapiens_hsa001900.18377709
143Estrogen signaling pathway_Homo sapiens_hsa049150.18096309
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18078159
145MAPK signaling pathway_Homo sapiens_hsa040100.16035202
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15694392
147Legionellosis_Homo sapiens_hsa051340.14887502
148Taste transduction_Homo sapiens_hsa047420.14808357
149Malaria_Homo sapiens_hsa051440.14031222

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