KLK12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.81318972
2transepithelial transport (GO:0070633)9.32141580
3regulation of T-helper 1 cell differentiation (GO:0045625)9.23394285
4positive regulation of antigen processing and presentation (GO:0002579)8.08399847
5positive regulation of Cdc42 GTPase activity (GO:0043089)7.57346695
6cellular protein complex localization (GO:0034629)7.37304733
7positive regulation of glycoprotein biosynthetic process (GO:0010560)6.63819681
8response to nitric oxide (GO:0071731)6.51478889
9regulation of antigen processing and presentation (GO:0002577)6.40747599
10positive regulation of granulocyte chemotaxis (GO:0071624)6.28755567
11positive regulation of T-helper 1 type immune response (GO:0002827)6.21336270
12epidermis development (GO:0008544)6.18826923
13striated muscle atrophy (GO:0014891)6.01100262
14skeletal muscle adaptation (GO:0043501)5.88290785
15positive regulation of T-helper cell differentiation (GO:0045624)5.78732088
16positive regulation of glycoprotein metabolic process (GO:1903020)5.68156928
17muscle atrophy (GO:0014889)5.64059053
18negative regulation of muscle hypertrophy (GO:0014741)5.63975296
19response to phenylpropanoid (GO:0080184)5.62235776
20hemidesmosome assembly (GO:0031581)5.59650067
21keratinocyte differentiation (GO:0030216)5.57768656
22peptide cross-linking (GO:0018149)5.57630639
23positive regulation of neutrophil migration (GO:1902624)5.48301617
24positive regulation of neutrophil chemotaxis (GO:0090023)5.48301617
25synaptic vesicle maturation (GO:0016188)5.38866052
26apical protein localization (GO:0045176)5.32204976
27leukocyte tethering or rolling (GO:0050901)5.27747399
28skeletal muscle tissue regeneration (GO:0043403)5.24732472
29desmosome organization (GO:0002934)5.22071872
30imidazole-containing compound metabolic process (GO:0052803)5.19507385
31establishment of skin barrier (GO:0061436)5.16698718
32synapsis (GO:0007129)5.11980166
33O-glycan processing (GO:0016266)5.08031687
34response to prostaglandin E (GO:0034695)5.07971148
35regulation of helicase activity (GO:0051095)5.02370215
36hair cell differentiation (GO:0035315)5.01937006
37establishment of planar polarity (GO:0001736)4.97815960
38establishment of tissue polarity (GO:0007164)4.97815960
39heterotypic cell-cell adhesion (GO:0034113)4.96436251
40response to gravity (GO:0009629)4.82772135
41complement activation, classical pathway (GO:0006958)4.81808684
42keratinocyte proliferation (GO:0043616)4.79482936
43citrulline biosynthetic process (GO:0019240)4.76688262
44multicellular organismal water homeostasis (GO:0050891)4.75094662
45cellular anion homeostasis (GO:0030002)4.72659383
46phosphate ion homeostasis (GO:0055062)4.70605692
47trivalent inorganic anion homeostasis (GO:0072506)4.70605692
48regulation of ruffle assembly (GO:1900027)4.68174198
49positive regulation of interleukin-1 beta secretion (GO:0050718)4.68089148
50regulation of water loss via skin (GO:0033561)4.67774389
51dendritic cell chemotaxis (GO:0002407)4.65600027
52regulation of T-helper 1 type immune response (GO:0002825)4.56974672
53hair follicle morphogenesis (GO:0031069)4.56333851
54primary alcohol catabolic process (GO:0034310)4.52870338
55protein complex localization (GO:0031503)4.51578194
56collecting duct development (GO:0072044)4.50110273
57antimicrobial humoral response (GO:0019730)4.41250850
58response to muscle activity (GO:0014850)4.40942567
59positive regulation of interleukin-1 secretion (GO:0050716)4.34698323
60epidermal cell differentiation (GO:0009913)4.27745085
61gap junction assembly (GO:0016264)4.20126476
62positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.19305611
63ectoderm development (GO:0007398)4.09455593
64regulation of interleukin-1 beta secretion (GO:0050706)4.08009582
65epithelial cell differentiation (GO:0030855)4.06444863
66skin development (GO:0043588)4.05458823
67detection of bacterium (GO:0016045)4.05372930
68regulation of T-helper cell differentiation (GO:0045622)4.04966043
69intermediate filament organization (GO:0045109)4.03799362
70phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.00166815
71hydrogen peroxide biosynthetic process (GO:0050665)3.99661261
72DNA strand renaturation (GO:0000733)3.98092597
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95234165
74negative regulation of skeletal muscle tissue development (GO:0048642)3.93906505
75asymmetric protein localization (GO:0008105)3.92880194
76maintenance of gastrointestinal epithelium (GO:0030277)3.92795185
77negative regulation of interleukin-8 production (GO:0032717)3.90791309
78regulation of neutrophil chemotaxis (GO:0090022)3.90375391
79regulation of neutrophil migration (GO:1902622)3.90375391
80positive regulation of NF-kappaB import into nucleus (GO:0042346)3.90104217
81planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87131594
82regulation of bile acid biosynthetic process (GO:0070857)3.85864766
83eyelid development in camera-type eye (GO:0061029)3.84746259
84positive regulation of interleukin-1 beta production (GO:0032731)3.82813218
85localization within membrane (GO:0051668)3.80999091
86response to prostaglandin (GO:0034694)3.80348795
87water homeostasis (GO:0030104)3.78321857
88sequestering of metal ion (GO:0051238)3.74082162
89regulation of granulocyte chemotaxis (GO:0071622)3.73358716
90aorta morphogenesis (GO:0035909)3.73056498
91regulation of Cdc42 GTPase activity (GO:0043088)3.72266567
92complement activation (GO:0006956)3.70576000
93vocalization behavior (GO:0071625)3.70270225
94lipoxygenase pathway (GO:0019372)3.67389569
95regulation of interleukin-1 secretion (GO:0050704)3.65566619
96cytokine secretion (GO:0050663)3.63886115
97ovulation from ovarian follicle (GO:0001542)3.60199016
98positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.58925822
99regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.58247143
100antibacterial humoral response (GO:0019731)3.57528001
101detection of other organism (GO:0098543)3.55433560
102positive regulation of urine volume (GO:0035810)3.54147421
103molting cycle (GO:0042303)3.49627001
104hair cycle (GO:0042633)3.49627001
105intestinal epithelial cell development (GO:0060576)3.48430939
106reactive oxygen species biosynthetic process (GO:1903409)3.48362515
107positive regulation of epidermal cell differentiation (GO:0045606)3.45832139
108angiotensin maturation (GO:0002003)3.44910064
109oogenesis (GO:0048477)3.44135769
110negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.42902689
111citrulline metabolic process (GO:0000052)3.40080937
112fucosylation (GO:0036065)3.39284752
113chronic inflammatory response (GO:0002544)3.37188085
114negative regulation of cell-cell adhesion (GO:0022408)3.36198187
115dendritic cell migration (GO:0036336)3.33934448
116positive regulation of interleukin-1 production (GO:0032732)3.32238837
117membrane raft organization (GO:0031579)3.30900272
118ethanol metabolic process (GO:0006067)3.30374407
119glomerular filtration (GO:0003094)3.27137678
120keratinocyte development (GO:0003334)3.26845779
121dendritic cell differentiation (GO:0097028)3.22129583
122positive regulation of respiratory burst (GO:0060267)3.22034407
123fucose catabolic process (GO:0019317)3.17927772
124L-fucose metabolic process (GO:0042354)3.17927772
125L-fucose catabolic process (GO:0042355)3.17927772
126negative regulation of fatty acid biosynthetic process (GO:0045717)3.17897760
127fatty acid homeostasis (GO:0055089)3.13217194
128olfactory bulb development (GO:0021772)3.12527892
129protein O-linked glycosylation (GO:0006493)3.12423776
130positive regulation of cholesterol efflux (GO:0010875)3.11689520
131regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.06985043
132renal filtration (GO:0097205)3.06893187
133positive regulation of monocyte chemotaxis (GO:0090026)3.05874873
134epithelial cell-cell adhesion (GO:0090136)3.05596122
135negative regulation of keratinocyte proliferation (GO:0010839)3.04694134
136regulation of MHC class II biosynthetic process (GO:0045346)3.04489222
137regulation of keratinocyte differentiation (GO:0045616)3.04392566
138regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.03695235
139hypotonic response (GO:0006971)3.01773396
140sympathetic nervous system development (GO:0048485)3.01244437
141single strand break repair (GO:0000012)2.98067138
142renal absorption (GO:0070293)2.96691275
143potassium ion homeostasis (GO:0055075)2.96630026
144GDP-mannose metabolic process (GO:0019673)2.96058810
145epithelial structure maintenance (GO:0010669)2.94728552
146positive regulation of epidermis development (GO:0045684)2.94447409
147negative regulation of myotube differentiation (GO:0010832)2.93206577
148ethanol oxidation (GO:0006069)2.90610320
149positive regulation of interleukin-12 production (GO:0032735)2.89755938
150epithelium development (GO:0060429)2.89457283
151positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.89322922
152negative regulation of biomineral tissue development (GO:0070168)2.88988919
153positive regulation of insulin receptor signaling pathway (GO:0046628)2.88837581
154regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.86816877
155negative regulation of bone mineralization (GO:0030502)2.85740856
156oligosaccharide biosynthetic process (GO:0009312)2.84223609
157regulation of T cell migration (GO:2000404)2.83014668
158regulation of G0 to G1 transition (GO:0070316)2.80993562
159renal tubule development (GO:0061326)2.80907203
160defense response to fungus (GO:0050832)2.80139828
161regulation of monocyte chemotaxis (GO:0090025)2.76372113
162negative regulation of neurological system process (GO:0031645)2.75266011
163one-carbon compound transport (GO:0019755)2.73212740
164protein activation cascade (GO:0072376)2.63206096
165Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60415566
166regulation of respiratory burst (GO:0060263)2.60287296
167phenylpropanoid metabolic process (GO:0009698)2.56771657
168cellular response to retinoic acid (GO:0071300)2.55755716
169wound healing (GO:0042060)2.52268587
170leukocyte aggregation (GO:0070486)2.51492508
171regulation of epidermal cell differentiation (GO:0045604)2.51250044
172negative regulation of cell-substrate adhesion (GO:0010812)2.51135695
173NADH metabolic process (GO:0006734)2.50998549
174regulation of establishment of planar polarity (GO:0090175)2.48343119
175excretion (GO:0007588)2.48134721
176arachidonic acid secretion (GO:0050482)2.46160324
177icosanoid secretion (GO:0032309)2.46160324
178negative regulation of interferon-gamma production (GO:0032689)2.45681435
179regulation of RIG-I signaling pathway (GO:0039535)2.44901036
180regulation of dendritic cell antigen processing and presentation (GO:0002604)11.8909926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.16641910
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.08716912
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.56601136
4KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.49207061
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.45033131
6ESR1_20079471_ChIP-ChIP_T-47D_Human2.44111460
7KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.36383495
8DROSHA_22980978_ChIP-Seq_HELA_Human2.33960420
9JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92603481
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90933856
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89004198
12ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.87368651
13VDR_22108803_ChIP-Seq_LS180_Human1.86966919
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85183117
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.80716600
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78740650
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78740650
18TP63_22573176_ChIP-Seq_HFKS_Human1.76346049
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76326907
20SOX2_27498859_Chip-Seq_STOMACH_Mouse1.75638087
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75340192
22LXR_22292898_ChIP-Seq_THP-1_Human1.66926437
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64708520
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61988178
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60018222
26SMC4_20622854_ChIP-Seq_HELA_Human1.59118448
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.57473941
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.56891732
29ATF3_27146783_Chip-Seq_COLON_Human1.56213300
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.54320275
31TP53_18474530_ChIP-ChIP_U2OS_Human1.54099843
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53795073
33CTCF_27219007_Chip-Seq_Bcells_Human1.53739614
34GATA6_25053715_ChIP-Seq_YYC3_Human1.52832335
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.51882734
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51670003
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.51089049
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.50742444
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48666519
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.48554378
41GATA4_25053715_ChIP-Seq_YYC3_Human1.48471298
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45509214
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.44439054
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43838479
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43254173
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.40858809
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38289564
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.36176253
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35883564
50ERG_20517297_ChIP-Seq_VCAP_Human1.35679324
51FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34656250
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32997605
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32102318
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31990417
55E2F1_20622854_ChIP-Seq_HELA_Human1.30120764
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28432389
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27185626
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25560888
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.22557212
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.21012301
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20663802
62* SA1_27219007_Chip-Seq_Bcells_Human1.19554113
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.19010785
64CJUN_26792858_Chip-Seq_BT549_Human1.18789138
65EZH2_22144423_ChIP-Seq_EOC_Human1.18356677
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16560798
67CEBPB_22108803_ChIP-Seq_LS180_Human1.16156478
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15953490
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15648592
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13846880
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13268134
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.13213475
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13116080
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12713545
75RACK7_27058665_Chip-Seq_MCF-7_Human1.11422979
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.10723522
77CREB1_26743006_Chip-Seq_LNCaP_Human1.08816627
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08470918
79AHR_22903824_ChIP-Seq_MCF-7_Human1.07867451
80* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06751763
81* BCOR_27268052_Chip-Seq_Bcells_Human1.06595476
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.05963777
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.05808991
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05366596
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04026752
86SOX2_20726797_ChIP-Seq_SW620_Human1.03229889
87KDM2B_26808549_Chip-Seq_K562_Human1.01786506
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.01735176
89CTCF_20526341_ChIP-Seq_ESCs_Human1.00771183
90* RUNX1_27514584_Chip-Seq_MCF-7_Human1.00166658
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00073275
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99726715
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.98950142
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.98175419
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97784081
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.97501689
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97319042
98NANOG_20526341_ChIP-Seq_ESCs_Human0.96965846
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.96764129
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94879291
101NFE2_27457419_Chip-Seq_LIVER_Mouse0.92841343
102CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91787462
103P68_20966046_ChIP-Seq_HELA_Human0.91413708
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.90643160
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.89903896
106RXR_22108803_ChIP-Seq_LS180_Human0.89309159
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89033074
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88692214
109STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88019585
110P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87769246
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.87726818
112TAF15_26573619_Chip-Seq_HEK293_Human0.87224099
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86492779
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86086726
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85951339
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.85501353
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84614971
118AR_21572438_ChIP-Seq_LNCaP_Human0.84446764
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84190175
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83796769
121* PHF8_20622854_ChIP-Seq_HELA_Human0.83659721
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.83308416
123CLOCK_20551151_ChIP-Seq_293T_Human0.83038242
124MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.82020473
125JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81900081
126CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81078517
127GATA1_19941826_ChIP-Seq_K562_Human0.80979162
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79579084
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79579084
130RBPJ_21746931_ChIP-Seq_IB4_Human0.78875983
131GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78844082
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.78797726
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.78747706
134KDM2B_26808549_Chip-Seq_REH_Human0.78704925
135TP63_23658742_ChIP-Seq_EP156T_Human0.78287624
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78100427
137RUNX1_27457419_Chip-Seq_LIVER_Mouse0.78004609
138GATA2_19941826_ChIP-Seq_K562_Human0.77200321
139* BCL6_27268052_Chip-Seq_Bcells_Human0.77072886
140KLF5_25053715_ChIP-Seq_YYC3_Human0.76940079
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.76866442
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76846954
143CSB_26484114_Chip-Seq_FIBROBLAST_Human0.76733639
144* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76577067
145ISL1_27105846_Chip-Seq_CPCs_Mouse0.76216947
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76172643
147OCT4_20526341_ChIP-Seq_ESCs_Human0.76046258
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75995419
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75992727
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75927431
151CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75745549
152OCT4_18555785_Chip-Seq_ESCs_Mouse0.75552218
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75199258
154EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75000590
155GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74871392
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74808702
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.73892062
158SPI1_20517297_ChIP-Seq_HL60_Human0.73879073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.94738544
2MP0002796_impaired_skin_barrier5.72204130
3MP0005275_abnormal_skin_tensile4.71676500
4MP0000685_abnormal_immune_system4.24927378
5MP0000579_abnormal_nail_morphology4.16624123
6MP0002254_reproductive_system_inflammat3.77687782
7MP0005501_abnormal_skin_physiology3.59865658
8MP0005647_abnormal_sex_gland3.55453060
9MP0002160_abnormal_reproductive_system3.30074526
10MP0000467_abnormal_esophagus_morphology3.22767747
11MP0008789_abnormal_olfactory_epithelium3.20457711
12MP0003705_abnormal_hypodermis_morpholog2.80641778
13MP0000465_gastrointestinal_hemorrhage2.73394880
14MP0001346_abnormal_lacrimal_gland2.67057139
15MP0005499_abnormal_olfactory_system2.49386590
16MP0005394_taste/olfaction_phenotype2.49386590
17MP0004264_abnormal_extraembryonic_tissu2.43418016
18MP0002876_abnormal_thyroid_physiology2.37643737
19MP0002089_abnormal_postnatal_growth/wei2.30618745
20MP0005377_hearing/vestibular/ear_phenot2.21165436
21MP0003878_abnormal_ear_physiology2.21165436
22MP0005645_abnormal_hypothalamus_physiol2.17507949
23MP0002138_abnormal_hepatobiliary_system2.15326611
24MP0002060_abnormal_skin_morphology2.15047576
25MP0003453_abnormal_keratinocyte_physiol2.13005245
26MP0000427_abnormal_hair_cycle2.11793126
27MP0001216_abnormal_epidermal_layer2.07096198
28MP0004381_abnormal_hair_follicle1.95435271
29MP0004510_myositis1.93061257
30MP0010771_integument_phenotype1.91573631
31MP0003045_fibrosis1.91101196
32MP0005503_abnormal_tendon_morphology1.88302114
33MP0010352_gastrointestinal_tract_polyps1.83771529
34MP0000762_abnormal_tongue_morphology1.83616742
35MP0002234_abnormal_pharynx_morphology1.83334757
36MP0004885_abnormal_endolymph1.77779837
37MP0001849_ear_inflammation1.72922817
38MP0003566_abnormal_cell_adhesion1.65111028
39MP0002735_abnormal_chemical_nociception1.64765324
40MP0008057_abnormal_DNA_replication1.63693809
41MP0000377_abnormal_hair_follicle1.62929743
42MP0000383_abnormal_hair_follicle1.60239444
43MP0000371_diluted_coat_color1.54679417
44MP0002249_abnormal_larynx_morphology1.53085770
45MP0000566_synostosis1.50860449
46MP0001765_abnormal_ion_homeostasis1.50755334
47MP0006054_spinal_hemorrhage1.50525567
48MP0004185_abnormal_adipocyte_glucose1.38914771
49MP0004947_skin_inflammation1.38856354
50MP0005389_reproductive_system_phenotype1.38320479
51MP0001348_abnormal_lacrimal_gland1.36804212
52MP0002877_abnormal_melanocyte_morpholog1.32738868
53MP0010234_abnormal_vibrissa_follicle1.31922035
54MP0000678_abnormal_parathyroid_gland1.30685331
55MP0005451_abnormal_body_composition1.27791988
56MP0002108_abnormal_muscle_morphology1.26841539
57MP0010678_abnormal_skin_adnexa1.23194279
58MP0004858_abnormal_nervous_system1.22139525
59MP0002098_abnormal_vibrissa_morphology1.22062604
60MP0009333_abnormal_splenocyte_physiolog1.18893661
61MP0004019_abnormal_vitamin_homeostasis1.17020991
62MP0004270_analgesia1.15021588
63MP0001666_abnormal_nutrient_absorption1.12048176
64MP0000372_irregular_coat_pigmentation1.10853979
65MP0009053_abnormal_anal_canal1.10206457
66MP0010155_abnormal_intestine_physiology1.04393606
67MP0000647_abnormal_sebaceous_gland1.02600087
68MP0001188_hyperpigmentation1.02590787
69MP0000470_abnormal_stomach_morphology0.98968011
70MP0003941_abnormal_skin_development0.98600058
71MP0005360_urolithiasis0.97128887
72MP0003828_pulmonary_edema0.96411883
73MP0008004_abnormal_stomach_pH0.95925553
74MP0002971_abnormal_brown_adipose0.94490588
75MP0001191_abnormal_skin_condition0.92287011
76MP0003638_abnormal_response/metabolism_0.89525195
77MP0009643_abnormal_urine_homeostasis0.88315937
78MP0003315_abnormal_perineum_morphology0.88296487
79MP0009931_abnormal_skin_appearance0.85313420
80MP0000049_abnormal_middle_ear0.84594510
81MP0004782_abnormal_surfactant_physiolog0.83382063
82MP0000751_myopathy0.82849830
83MP0005636_abnormal_mineral_homeostasis0.82767179
84MP0001851_eye_inflammation0.81159974
85MP0001243_abnormal_dermal_layer0.78009394
86MP0005666_abnormal_adipose_tissue0.77671092
87MP0005023_abnormal_wound_healing0.76474548
88MP0002177_abnormal_outer_ear0.75423273
89MP0003866_abnormal_defecation0.74248960
90MP0005310_abnormal_salivary_gland0.74011180
91MP0005248_abnormal_Harderian_gland0.73207899
92MP0002106_abnormal_muscle_physiology0.72130949
93MP0000367_abnormal_coat/_hair0.71271119
94MP0001485_abnormal_pinna_reflex0.70795732
95MP0002075_abnormal_coat/hair_pigmentati0.70096279
96MP0002069_abnormal_eating/drinking_beha0.69929695
97MP0002734_abnormal_mechanical_nocicepti0.69899044
98MP0002282_abnormal_trachea_morphology0.69662022
99MP0002896_abnormal_bone_mineralization0.69085908
100MP0002095_abnormal_skin_pigmentation0.68956846
101MP0000477_abnormal_intestine_morphology0.67633304
102MP0005623_abnormal_meninges_morphology0.66208674
103MP0003195_calcinosis0.66081417
104MP0001664_abnormal_digestion0.64749530
105MP0005334_abnormal_fat_pad0.63739045
106MP0003300_gastrointestinal_ulcer0.61431031
107MP0000003_abnormal_adipose_tissue0.60268204
108MP0002168_other_aberrant_phenotype0.60177826
109MP0004859_abnormal_synaptic_plasticity0.59001218
110MP0010030_abnormal_orbit_morphology0.58600892
111MP0001542_abnormal_bone_strength0.58578098
112MP0000462_abnormal_digestive_system0.58104787
113MP0002233_abnormal_nose_morphology0.57659617
114MP0001835_abnormal_antigen_presentation0.57618554
115MP0003136_yellow_coat_color0.57613541
116MP0005369_muscle_phenotype0.57545921
117MP0003890_abnormal_embryonic-extraembry0.56281222
118MP0000749_muscle_degeneration0.55656625
119MP0002136_abnormal_kidney_physiology0.54796786
120MP0002148_abnormal_hypersensitivity_rea0.54540260
121MP0009764_decreased_sensitivity_to0.52906141
122MP0009115_abnormal_fat_cell0.52318741
123MP0005375_adipose_tissue_phenotype0.52101521
124MP0009379_abnormal_foot_pigmentation0.51162280
125MP0005409_darkened_coat_color0.51124757
126MP0002733_abnormal_thermal_nociception0.50331166
127MP0000613_abnormal_salivary_gland0.48743534
128MP0008875_abnormal_xenobiotic_pharmacok0.48723343
129MP0005166_decreased_susceptibility_to0.48699729
130MP0001186_pigmentation_phenotype0.48036379
131MP0008438_abnormal_cutaneous_collagen0.47910359
132MP0002697_abnormal_eye_size0.47800609
133MP0003303_peritoneal_inflammation0.46680586
134MP0000681_abnormal_thyroid_gland0.46227688
135MP0005448_abnormal_energy_balance0.45148064
136MP0005365_abnormal_bile_salt0.44417645
137MP0005381_digestive/alimentary_phenotyp0.43779128
138MP0005197_abnormal_uvea_morphology0.42569402
139MP0003183_abnormal_peptide_metabolism0.40845181
140MP0005085_abnormal_gallbladder_physiolo0.39712068
141MP0001663_abnormal_digestive_system0.39046719
142MP0003724_increased_susceptibility_to0.37790116
143MP0005670_abnormal_white_adipose0.37408782
144MP0001958_emphysema0.36763975
145MP0003879_abnormal_hair_cell0.35480425
146MP0009840_abnormal_foam_cell0.33924980
147MP0001270_distended_abdomen0.33615679
148MP0005193_abnormal_anterior_eye0.32372996
149MP0005165_increased_susceptibility_to0.31971408
150MP0002111_abnormal_tail_morphology0.31516971
151MP0009780_abnormal_chondrocyte_physiolo0.31437359
152MP0001784_abnormal_fluid_regulation0.31024876
153MP0003011_delayed_dark_adaptation0.29910620
154MP0003191_abnormal_cellular_cholesterol0.27223874
155MP0001533_abnormal_skeleton_physiology0.26509963
156MP0003806_abnormal_nucleotide_metabolis0.25492518

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.45334754
2Plantar hyperkeratosis (HP:0007556)6.51676368
3Palmoplantar hyperkeratosis (HP:0000972)5.92066279
4Palmar hyperkeratosis (HP:0010765)5.58687167
5Milia (HP:0001056)5.49802449
6Abnormality of nail color (HP:0100643)4.95889124
7Eczematoid dermatitis (HP:0000976)4.88828907
8Right ventricular cardiomyopathy (HP:0011663)4.67930444
9Thick nail (HP:0001805)4.67771578
10Fragile nails (HP:0001808)4.65377683
11Oral leukoplakia (HP:0002745)4.48616765
12Corneal erosion (HP:0200020)4.44634802
13Onycholysis (HP:0001806)4.35280263
14Erythema (HP:0010783)4.33985011
15Hyperactive renin-angiotensin system (HP:0000841)4.22351759
16Abnormality of small intestinal villus morphology (HP:0011472)4.18769878
17Villous atrophy (HP:0011473)4.18769878
18Gangrene (HP:0100758)4.03092969
19Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.71472874
20Malnutrition (HP:0004395)3.53658046
21Symphalangism affecting the phalanges of the hand (HP:0009773)3.42505219
22Nasal polyposis (HP:0100582)3.42071757
23Hypergammaglobulinemia (HP:0010702)3.40912142
24Abnormality of the phalanges of the 5th finger (HP:0004213)3.40763705
25Abnormality of the salivary glands (HP:0010286)3.37591271
26Abnormal blistering of the skin (HP:0008066)3.36622931
27Hypotrichosis (HP:0001006)3.31485007
28Type I diabetes mellitus (HP:0100651)3.30806843
29Atrophic scars (HP:0001075)3.22855093
30Erythroderma (HP:0001019)3.16664404
31Absent eyelashes (HP:0000561)3.12572722
32Myopathic facies (HP:0002058)3.12269807
33Abnormality of the axillary hair (HP:0100134)3.09538788
34Abnormality of secondary sexual hair (HP:0009888)3.09538788
35Hyperkalemia (HP:0002153)3.07366651
36Abnormality of the nasal mucosa (HP:0000433)3.05884406
37Sparse scalp hair (HP:0002209)3.04512317
38Ventricular tachycardia (HP:0004756)3.03939705
39Pili torti (HP:0003777)3.03139280
40Fragile skin (HP:0001030)3.01154770
41Aplasia cutis congenita (HP:0001057)2.96919733
42Brittle hair (HP:0002299)2.96577825
43Congenital ichthyosiform erythroderma (HP:0007431)2.94563769
44Conjunctival hamartoma (HP:0100780)2.90821348
45Supernumerary nipples (HP:0002558)2.88568162
46Chronic bronchitis (HP:0004469)2.82783434
47Urticaria (HP:0001025)2.80001920
48Alopecia of scalp (HP:0002293)2.77802226
49Acanthosis nigricans (HP:0000956)2.76518943
50Decreased circulating renin level (HP:0003351)2.73185208
51Woolly hair (HP:0002224)2.68411235
52Sparse eyelashes (HP:0000653)2.68018262
53Absent hair (HP:0002298)2.64848283
54Abnormality of placental membranes (HP:0011409)2.63601590
55Amniotic constriction ring (HP:0009775)2.63601590
56Popliteal pterygium (HP:0009756)2.63440662
57Natal tooth (HP:0000695)2.62767229
58Nail dystrophy (HP:0008404)2.62111299
59Short 5th finger (HP:0009237)2.60466829
60Bilateral sensorineural hearing impairment (HP:0008619)2.55797294
61Palmoplantar keratoderma (HP:0000982)2.49346659
62Ectropion (HP:0000656)2.48635561
63Sepsis (HP:0100806)2.46027545
64Tongue fasciculations (HP:0001308)2.44062615
65Absent speech (HP:0001344)2.41978662
66Palpebral edema (HP:0100540)2.40200447
67Broad nasal tip (HP:0000455)2.39833690
68Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.39259148
69Ridged nail (HP:0001807)2.38160252
70Abnormality of chloride homeostasis (HP:0011422)2.33213354
71Recurrent gram-negative bacterial infections (HP:0005420)2.31095499
72Dehydration (HP:0001944)2.30581473
73Muscle fibrillation (HP:0010546)2.28656519
74Enlarged kidneys (HP:0000105)2.27374295
75Tetraparesis (HP:0002273)2.26160467
76Hyperglycemia (HP:0003074)2.26001589
77Severe muscular hypotonia (HP:0006829)2.24363649
78Pruritus (HP:0000989)2.23986661
79Lip pit (HP:0100267)2.22676894
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.21863351
81Muscle fiber splitting (HP:0003555)2.21451901
82Advanced eruption of teeth (HP:0006288)2.21322727
83Increased connective tissue (HP:0009025)2.21301929
84Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19769997
85Tubulointerstitial fibrosis (HP:0005576)2.18497333
86Recurrent cutaneous fungal infections (HP:0011370)2.17878290
87Chronic mucocutaneous candidiasis (HP:0002728)2.17878290
88Furrowed tongue (HP:0000221)2.17484936
89Muscle fiber inclusion bodies (HP:0100299)2.14873807
90Seborrheic dermatitis (HP:0001051)2.14786848
91Lack of skin elasticity (HP:0100679)2.13608894
92Abnormality of the gastric mucosa (HP:0004295)2.11981990
93Renal salt wasting (HP:0000127)2.11958178
94Abnormality of the distal phalanges of the toes (HP:0010182)2.10893594
95Abnormality of renin-angiotensin system (HP:0000847)2.10165807
96Keratoconjunctivitis (HP:0001096)2.07846418
97Potter facies (HP:0002009)2.04662741
98Facial shape deformation (HP:0011334)2.04662741
99Esophageal atresia (HP:0002032)2.00860806
100Autoamputation (HP:0001218)1.97458220
101Hypohidrosis (HP:0000966)1.97188157
102Abnormal hair laboratory examination (HP:0003328)1.96484576
103Hypoplasia of dental enamel (HP:0006297)1.95129831
104Chronic obstructive pulmonary disease (HP:0006510)1.95005953
105Obstructive lung disease (HP:0006536)1.95005953
106Blepharitis (HP:0000498)1.94536817
107Multifactorial inheritance (HP:0001426)1.92557188
108Vertebral compression fractures (HP:0002953)1.92334986
109Distal lower limb muscle weakness (HP:0009053)1.92139652
110Hyperaldosteronism (HP:0000859)1.90265387
111Papilloma (HP:0012740)1.90072979
112Verrucae (HP:0200043)1.90072979
113Anosmia (HP:0000458)1.87969329
114Keratoconjunctivitis sicca (HP:0001097)1.86853396
115Pustule (HP:0200039)1.86170334
116Gingivitis (HP:0000230)1.84370310
117Fatigable weakness (HP:0003473)1.83365681
118Abnormality of the neuromuscular junction (HP:0003398)1.83365681
119Hoarse voice (HP:0001609)1.82007394
120Elevated erythrocyte sedimentation rate (HP:0003565)1.81629369
121Distal lower limb amyotrophy (HP:0008944)1.80501076
122Recurrent fungal infections (HP:0002841)1.80011762
123Abnormal sex determination (HP:0012244)1.79632821
124Sex reversal (HP:0012245)1.79632821
125Systemic lupus erythematosus (HP:0002725)1.79321035
126Reticulocytosis (HP:0001923)1.77515230
127Intellectual disability, mild (HP:0001256)1.77504285
128Small hand (HP:0200055)1.77446056
129Hypercortisolism (HP:0001578)1.76012494
130Thin bony cortex (HP:0002753)1.75716724
131Sudden death (HP:0001699)1.75397110
132Hyperhidrosis (HP:0000975)1.73933069
133Hamartoma of the eye (HP:0010568)1.73663505
134Abnormality of proline metabolism (HP:0010907)1.73328112
135Hydroxyprolinuria (HP:0003080)1.73328112
136Neonatal death (HP:0003811)1.73242243
137Hyporeflexia of lower limbs (HP:0002600)1.72843536
138Parakeratosis (HP:0001036)1.72565132
139Elbow flexion contracture (HP:0002987)1.71998723
140Emphysema (HP:0002097)1.71792109
141Hypoplastic labia majora (HP:0000059)1.70287655
142Fine hair (HP:0002213)1.65756384
143Trismus (HP:0000211)1.64560822
144Coarse hair (HP:0002208)1.64497158
145Cystic hygroma (HP:0000476)1.63888080
146Recurrent corneal erosions (HP:0000495)1.62028670
147Abnormality of the labia majora (HP:0012881)1.59218409
148Hyponatremia (HP:0002902)1.58122487
149Skin rash (HP:0000988)1.58109176
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.54771808
151Skin ulcer (HP:0200042)1.54659155
152Curly hair (HP:0002212)1.52224293
153Enlarged epiphyses (HP:0010580)1.50782582
154Hyperparathyroidism (HP:0000843)1.48160594
155Recurrent bacterial skin infections (HP:0005406)1.44991792
156Abnormality of monocarboxylic acid metabolism (HP:0010996)1.44116086
157Hypoplastic toenails (HP:0001800)1.41190265
158Abnormality of the costochondral junction (HP:0000919)1.40909296
159Oligodontia (HP:0000677)1.39463416
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.39302544
161Skin pits (HP:0100276)1.38346653
162Dry skin (HP:0000958)1.37110278

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DYRK35.64180551
2DYRK1B4.12602916
3MAP3K23.99411127
4ERBB33.78909038
5ERN13.59160212
6RIPK12.82216954
7LATS12.76998885
8BMPR22.48905314
9MAP3K62.40437642
10GRK62.36411081
11TTN2.30889092
12WNK42.11258046
13NEK92.07802383
14LATS22.04521298
15EEF2K2.01976351
16FER1.92225527
17MAP3K141.91464130
18NME11.90342750
19PBK1.88430888
20EPHA21.74797232
21TRPM71.68187748
22BLK1.64972082
23NTRK11.64945941
24STK101.60989206
25LRRK21.58553426
26TAOK11.57892786
27MYLK1.55153618
28IRAK41.54840978
29STK391.48807957
30PINK11.48702583
31TNK21.44500193
32MST1R1.42940581
33DDR21.41333394
34EPHA31.39771277
35PHKG21.37778331
36PHKG11.37778331
37SMG11.34278210
38PTK61.33219397
39PIK3CG1.31239127
40PLK21.25768058
41MAP2K61.25366952
42DAPK21.23880475
43DYRK1A1.21317151
44PAK61.18989165
45NTRK31.18233493
46WNK11.14905420
47RPS6KA41.09662291
48CDC42BPA1.08530764
49MARK31.07772189
50NEK11.07288729
51MAPKAPK31.06896501
52FGFR31.06850018
53TRIB31.02977163
54MAPK150.99196802
55MAP3K90.97389399
56SIK10.95021003
57FGFR40.94548417
58SYK0.94010708
59PRKCQ0.93040192
60RIPK40.86340200
61EPHB10.85969674
62LIMK10.84628445
63NTRK20.82169687
64PRKG20.80483447
65PRKD20.79387058
66SCYL20.79009483
67LMTK20.77820375
68MAP3K10.75650744
69MAP2K20.75585400
70VRK20.72046269
71HCK0.71412433
72MET0.71221210
73PIM20.69932819
74PIK3CA0.68530051
75TYRO30.67865158
76IRAK10.67123573
77STK240.66992094
78PTK20.64809926
79MAP3K120.62419827
80ILK0.61596758
81EPHB20.60419628
82FGR0.60282610
83BCR0.58494769
84PRKCI0.56490729
85MAPKAPK50.56389196
86DMPK0.56205247
87PKN20.55998242
88EPHA40.55899136
89RPS6KB20.55805975
90MAPKAPK20.55329358
91ZAP700.55004776
92PDPK10.52901398
93MAP3K30.50961807
94TGFBR10.50358596
95ERBB20.50345352
96ROCK20.50050587
97JAK30.49183254
98GRK10.48357913
99ACVR1B0.48189080
100STK38L0.46966236
101PRKAA20.46790650
102RPS6KA10.46689919
103TIE10.46514386
104TBK10.46248823
105OBSCN0.45709882
106ERBB40.44664435
107MAP3K70.44216173
108TYK20.44047520
109MAPK120.42522449
110CDK120.42376144
111IRAK30.41732252
112STK30.41540484
113SIK30.41533494
114ICK0.41308103
115CAMK2B0.40493182
116PDGFRA0.40406036
117NME20.40351568
118RET0.40282497
119KSR10.39969866
120MAP3K110.39706985
121PRKD10.38818668
122PRKCD0.38369172
123MATK0.38179710
124KSR20.37547228
125PAK20.37404385
126CSNK1E0.37118329
127VRK10.36183483
128SRC0.34455580
129MAP3K80.33657315
130MAP2K10.33582285
131NEK20.33065056
132PAK30.32908638
133STK380.32907617
134MAP2K40.32836377
135CSK0.32592385
136MARK20.32369608
137MAPK110.31998946
138TESK10.31270568
139ITK0.30744414
140MAP3K130.30438378
141CAMK2G0.30430410
142MST40.29857766
143PDGFRB0.28901770
144BMX0.28860432
145MAP3K40.26565579
146EGFR0.26544675
147ARAF0.26061928
148MTOR0.24044241
149PAK40.20881598
150IKBKE0.20123041
151IGF1R0.19225763
152SGK10.18886199
153NEK60.18193476
154FYN0.17029701
155CDK70.15551051

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003404.80010014
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.17135150
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.76890504
4Phenylalanine metabolism_Homo sapiens_hsa003603.49427007
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35945996
6Cyanoamino acid metabolism_Homo sapiens_hsa004603.04407768
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.56023370
8Linoleic acid metabolism_Homo sapiens_hsa005912.17347682
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09929597
10Phototransduction_Homo sapiens_hsa047442.01637552
11Renin-angiotensin system_Homo sapiens_hsa046142.01220009
12Retinol metabolism_Homo sapiens_hsa008301.98856018
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.89452711
14Fructose and mannose metabolism_Homo sapiens_hsa000511.75349162
15Arginine biosynthesis_Homo sapiens_hsa002201.71984835
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70179864
17Protein digestion and absorption_Homo sapiens_hsa049741.66830012
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.66468328
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.65329986
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64025340
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61602002
22Salivary secretion_Homo sapiens_hsa049701.57454327
23Tyrosine metabolism_Homo sapiens_hsa003501.53046766
24Olfactory transduction_Homo sapiens_hsa047401.49551114
25Sphingolipid metabolism_Homo sapiens_hsa006001.49549540
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.49505043
27Ether lipid metabolism_Homo sapiens_hsa005651.48843441
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.47285905
29Fat digestion and absorption_Homo sapiens_hsa049751.41451616
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38728008
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34569165
32Mineral absorption_Homo sapiens_hsa049781.27979517
33Fatty acid degradation_Homo sapiens_hsa000711.27695136
34Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26960231
35Dilated cardiomyopathy_Homo sapiens_hsa054141.25884834
36Arginine and proline metabolism_Homo sapiens_hsa003301.24926719
37Vitamin digestion and absorption_Homo sapiens_hsa049771.22906526
38Starch and sucrose metabolism_Homo sapiens_hsa005001.20342528
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.20163837
40Glutathione metabolism_Homo sapiens_hsa004801.15407133
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11057766
42ECM-receptor interaction_Homo sapiens_hsa045121.10378440
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08172678
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03908247
45beta-Alanine metabolism_Homo sapiens_hsa004101.02631337
46Arachidonic acid metabolism_Homo sapiens_hsa005901.00685722
47Glycerolipid metabolism_Homo sapiens_hsa005611.00351048
48PPAR signaling pathway_Homo sapiens_hsa033200.99515849
49Galactose metabolism_Homo sapiens_hsa000520.99219581
50Amphetamine addiction_Homo sapiens_hsa050310.98133870
51Circadian entrainment_Homo sapiens_hsa047130.98030368
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97894231
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97822304
54Collecting duct acid secretion_Homo sapiens_hsa049660.96669418
55Chemokine signaling pathway_Homo sapiens_hsa040620.92309831
56Staphylococcus aureus infection_Homo sapiens_hsa051500.92111311
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.91321017
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88106750
59Adherens junction_Homo sapiens_hsa045200.85080006
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85067528
61Primary immunodeficiency_Homo sapiens_hsa053400.83518631
62ABC transporters_Homo sapiens_hsa020100.82679287
63Calcium signaling pathway_Homo sapiens_hsa040200.81165944
64Amoebiasis_Homo sapiens_hsa051460.80735105
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79924807
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77623266
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77242633
68Tuberculosis_Homo sapiens_hsa051520.76828470
69Vibrio cholerae infection_Homo sapiens_hsa051100.74665594
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71922419
71Inositol phosphate metabolism_Homo sapiens_hsa005620.71879633
72Phagosome_Homo sapiens_hsa041450.68877108
73Focal adhesion_Homo sapiens_hsa045100.68393404
74Serotonergic synapse_Homo sapiens_hsa047260.68390832
75Acute myeloid leukemia_Homo sapiens_hsa052210.68201640
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65713930
77Sulfur metabolism_Homo sapiens_hsa009200.65527293
78Axon guidance_Homo sapiens_hsa043600.65123781
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64289834
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63299874
81Fatty acid biosynthesis_Homo sapiens_hsa000610.63130642
82Osteoclast differentiation_Homo sapiens_hsa043800.63074985
83Complement and coagulation cascades_Homo sapiens_hsa046100.62167562
84Ras signaling pathway_Homo sapiens_hsa040140.62145972
85Gastric acid secretion_Homo sapiens_hsa049710.61441759
86Notch signaling pathway_Homo sapiens_hsa043300.61363162
87Tight junction_Homo sapiens_hsa045300.60829217
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60565325
89Endocytosis_Homo sapiens_hsa041440.59997622
90Antigen processing and presentation_Homo sapiens_hsa046120.59483464
91Allograft rejection_Homo sapiens_hsa053300.59209553
92Renin secretion_Homo sapiens_hsa049240.58343243
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58130715
94VEGF signaling pathway_Homo sapiens_hsa043700.57229410
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56059539
96Hepatitis C_Homo sapiens_hsa051600.55632119
97Nitrogen metabolism_Homo sapiens_hsa009100.55161265
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.55012739
99Rheumatoid arthritis_Homo sapiens_hsa053230.54841469
100Pertussis_Homo sapiens_hsa051330.54810390
101MicroRNAs in cancer_Homo sapiens_hsa052060.54383353
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54257490
103Chemical carcinogenesis_Homo sapiens_hsa052040.53552857
104Leishmaniasis_Homo sapiens_hsa051400.53400356
105Autoimmune thyroid disease_Homo sapiens_hsa053200.52417682
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51945280
107Graft-versus-host disease_Homo sapiens_hsa053320.50272633
108Glioma_Homo sapiens_hsa052140.49851602
109Influenza A_Homo sapiens_hsa051640.49800309
110Rap1 signaling pathway_Homo sapiens_hsa040150.48986926
111Proteoglycans in cancer_Homo sapiens_hsa052050.48639059
112Synaptic vesicle cycle_Homo sapiens_hsa047210.48449977
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47942055
114Glucagon signaling pathway_Homo sapiens_hsa049220.47914753
115Toxoplasmosis_Homo sapiens_hsa051450.47750379
116Melanogenesis_Homo sapiens_hsa049160.47688138
117Other glycan degradation_Homo sapiens_hsa005110.46202983
118Bile secretion_Homo sapiens_hsa049760.44813752
119Bladder cancer_Homo sapiens_hsa052190.44617041
120Pancreatic secretion_Homo sapiens_hsa049720.44573846
121GnRH signaling pathway_Homo sapiens_hsa049120.44306517
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44128780
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43873697
124Fatty acid elongation_Homo sapiens_hsa000620.43685636
125Choline metabolism in cancer_Homo sapiens_hsa052310.43544717
126Taste transduction_Homo sapiens_hsa047420.43191342
127Glutamatergic synapse_Homo sapiens_hsa047240.43171036
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.42825578
129GABAergic synapse_Homo sapiens_hsa047270.42631482
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41542799
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40934956
132Malaria_Homo sapiens_hsa051440.40380725
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.39941694
134Viral myocarditis_Homo sapiens_hsa054160.38807368
135Asthma_Homo sapiens_hsa053100.37956121
136Oxytocin signaling pathway_Homo sapiens_hsa049210.35882677
137Dopaminergic synapse_Homo sapiens_hsa047280.35832510
138Type I diabetes mellitus_Homo sapiens_hsa049400.35745976
139Caffeine metabolism_Homo sapiens_hsa002320.35739467
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.35128268
141ErbB signaling pathway_Homo sapiens_hsa040120.35060154
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33383508
143Insulin resistance_Homo sapiens_hsa049310.32834330
144FoxO signaling pathway_Homo sapiens_hsa040680.32490895
145Basal cell carcinoma_Homo sapiens_hsa052170.32157490
146Pentose phosphate pathway_Homo sapiens_hsa000300.31916358
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31158992
148Insulin signaling pathway_Homo sapiens_hsa049100.30778531
149Salmonella infection_Homo sapiens_hsa051320.30406826
150Ovarian steroidogenesis_Homo sapiens_hsa049130.28317389
151Tryptophan metabolism_Homo sapiens_hsa003800.22973311

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