KLK13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptide cross-linking (GO:0018149)8.85738382
2keratinocyte differentiation (GO:0030216)8.32255528
3multicellular organismal water homeostasis (GO:0050891)7.59427543
4surfactant homeostasis (GO:0043129)7.58751900
5bundle of His cell to Purkinje myocyte communication (GO:0086069)7.30921002
6intermediate filament organization (GO:0045109)6.68328973
7water homeostasis (GO:0030104)6.23362210
8epidermal cell differentiation (GO:0009913)6.15532672
9epidermis development (GO:0008544)5.95534771
10chemical homeostasis within a tissue (GO:0048875)5.77529807
11detection of bacterium (GO:0016045)5.70283789
12transepithelial transport (GO:0070633)5.64515251
13one-carbon compound transport (GO:0019755)5.47274459
14ectoderm development (GO:0007398)5.37564660
15skin morphogenesis (GO:0043589)5.06146618
16apical protein localization (GO:0045176)4.93595266
17detection of other organism (GO:0098543)4.90513908
18phosphatidylserine acyl-chain remodeling (GO:0036150)4.70390879
19negative regulation of interleukin-17 production (GO:0032700)4.70186457
20sequestering of metal ion (GO:0051238)4.67063496
21eyelid development in camera-type eye (GO:0061029)4.48420944
22phosphatidylinositol acyl-chain remodeling (GO:0036149)4.45753502
23intermediate filament cytoskeleton organization (GO:0045104)4.44866387
24intermediate filament-based process (GO:0045103)4.25931354
25hair cell differentiation (GO:0035315)4.17211954
26cell-substrate junction assembly (GO:0007044)4.10817381
27keratinocyte development (GO:0003334)4.07699986
28skin development (GO:0043588)4.05162698
29adhesion of symbiont to host cell (GO:0044650)4.04491328
30virion attachment to host cell (GO:0019062)4.04491328
31negative regulation of bone mineralization (GO:0030502)3.99565509
32epithelial cell differentiation (GO:0030855)3.95812576
33fatty acid elongation (GO:0030497)3.84100354
34phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.75932005
35regulation of skeletal muscle contraction (GO:0014819)3.72255775
36establishment of apical/basal cell polarity (GO:0035089)3.72077939
37negative regulation of cell fate specification (GO:0009996)3.69578226
38asymmetric protein localization (GO:0008105)3.68526535
39regulation of natural killer cell differentiation (GO:0032823)3.62902387
40response to phenylpropanoid (GO:0080184)3.60216323
41negative regulation of biomineral tissue development (GO:0070168)3.55164920
42adhesion of symbiont to host (GO:0044406)3.53797363
43localization within membrane (GO:0051668)3.53330244
44polarized epithelial cell differentiation (GO:0030859)3.52488048
45regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.52092882
46phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.45675442
47regulation of keratinocyte differentiation (GO:0045616)3.37471296
48epithelial cell-cell adhesion (GO:0090136)3.34310513
49muscle organ morphogenesis (GO:0048644)3.32930704
50negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.29785793
51ventricular cardiac muscle cell action potential (GO:0086005)3.29658321
52phosphatidylcholine acyl-chain remodeling (GO:0036151)3.27745387
53mesodermal cell differentiation (GO:0048333)3.24622023
54antimicrobial humoral response (GO:0019730)3.24315607
55renal absorption (GO:0070293)3.19134249
56membrane raft organization (GO:0031579)3.16775371
57dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16485311
58planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15446929
59positive regulation of monocyte chemotaxis (GO:0090026)3.14787649
60viral transcription (GO:0019083)3.12707785
61establishment or maintenance of monopolar cell polarity (GO:0061339)3.08976118
62establishment of monopolar cell polarity (GO:0061162)3.08976118
63positive regulation of epidermis development (GO:0045684)3.06165479
64skeletal muscle adaptation (GO:0043501)3.05942288
65negative regulation of keratinocyte proliferation (GO:0010839)3.04560049
66keratinocyte proliferation (GO:0043616)3.03159247
67long-chain fatty acid biosynthetic process (GO:0042759)3.01685923
68regulation of axon regeneration (GO:0048679)3.00645860
69regulation of neuron projection regeneration (GO:0070570)3.00645860
70O-glycan processing (GO:0016266)2.99186893
71regulation of cardioblast differentiation (GO:0051890)2.98034793
72gas transport (GO:0015669)2.96980451
73regulation of T cell chemotaxis (GO:0010819)2.96141631
74positive regulation of T cell chemotaxis (GO:0010820)2.96141631
75intestinal epithelial cell development (GO:0060576)2.96064605
76phosphatidylserine metabolic process (GO:0006658)2.95433532
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95310533
78negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.93391905
79regulation of ruffle assembly (GO:1900027)2.93001317
80translational termination (GO:0006415)2.92836058
81epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91120189
82gap junction assembly (GO:0016264)2.90570206
83regulation of epidermal cell differentiation (GO:0045604)2.90066171
84negative regulation of response to cytokine stimulus (GO:0060761)2.89191774
85establishment of tissue polarity (GO:0007164)2.88989426
86establishment of planar polarity (GO:0001736)2.88989426
87maturation of SSU-rRNA (GO:0030490)2.88870556
88regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.88806296
89ceramide biosynthetic process (GO:0046513)2.85148997
90defense response to fungus (GO:0050832)2.85032373
91peptide catabolic process (GO:0043171)2.84599251
92regulation of natural killer cell activation (GO:0032814)2.83194363
93negative regulation of cell-cell adhesion (GO:0022408)2.83018618
94primary alcohol catabolic process (GO:0034310)2.81259499
95regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.80689823
96epithelium development (GO:0060429)2.79717271
97negative regulation of cell fate commitment (GO:0010454)2.78593236
98lipoxygenase pathway (GO:0019372)2.78464790
99positive regulation of epidermal cell differentiation (GO:0045606)2.78347941
100cellular response to interleukin-4 (GO:0071353)2.78050627
101ribosomal small subunit assembly (GO:0000028)2.76975988
102regulation of interleukin-17 production (GO:0032660)2.73346076
103regulation of epidermis development (GO:0045682)2.72157296
104regulation of T cell migration (GO:2000404)2.71611812
105regulation of heart rate by cardiac conduction (GO:0086091)2.70214550
106regulation of keratinocyte proliferation (GO:0010837)2.70042021
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.67496902
108atrioventricular valve morphogenesis (GO:0003181)2.66699209
109paraxial mesoderm development (GO:0048339)2.65720859
110retina homeostasis (GO:0001895)2.63066543
111detection of biotic stimulus (GO:0009595)2.62719701
112positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57274971
113striated muscle atrophy (GO:0014891)2.55759017
114cell wall macromolecule metabolic process (GO:0044036)2.55496463
115cell wall macromolecule catabolic process (GO:0016998)2.55496463
116positive regulation of granulocyte chemotaxis (GO:0071624)2.54688696
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54015057
118regulation of establishment of planar polarity (GO:0090175)2.53471205
119wound healing (GO:0042060)2.52699110
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51073112
121cochlea morphogenesis (GO:0090103)2.50551636
122regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50313755
123lung-associated mesenchyme development (GO:0060484)2.49446614
124response to UV-B (GO:0010224)2.47772109
125negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.46119545
126regulation of monocyte chemotaxis (GO:0090025)2.44716713
127translational elongation (GO:0006414)2.42826594
128negative regulation of interferon-gamma production (GO:0032689)2.42144725
129ribosomal small subunit biogenesis (GO:0042274)2.41387660
130hair follicle morphogenesis (GO:0031069)2.40420352
131alditol phosphate metabolic process (GO:0052646)2.40031673
132detection of external biotic stimulus (GO:0098581)2.39947395
133response to interleukin-4 (GO:0070670)2.37416711
134response to vitamin A (GO:0033189)2.35482684
135linoleic acid metabolic process (GO:0043651)2.35078620
136SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.34270780
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.33484648
138lateral sprouting from an epithelium (GO:0060601)2.33433776
139phospholipid catabolic process (GO:0009395)2.30540699
140regulation of cholesterol homeostasis (GO:2000188)2.30189538
141positive regulation of p38MAPK cascade (GO:1900745)2.29381488
142keratinization (GO:0031424)19.9322475
143hemidesmosome assembly (GO:0031581)12.2188857
144establishment of skin barrier (GO:0061436)11.6453600
145molting cycle (GO:0042303)11.3460109
146hair cycle (GO:0042633)11.3460109
147regulation of water loss via skin (GO:0033561)10.3987257
148desmosome organization (GO:0002934)10.3273981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.73471602
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.07164767
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.28155932
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99019289
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.64826242
6VDR_22108803_ChIP-Seq_LS180_Human2.63667275
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.62516092
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46139396
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.21660027
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.20938183
11ZNF263_19887448_ChIP-Seq_K562_Human2.19494808
12SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03068640
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03068640
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02500081
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.01366364
16TP63_17297297_ChIP-ChIP_HaCaT_Human15.2485842
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96624038
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.90614098
19SOX9_24532713_ChIP-Seq_HFSC_Mouse1.88782543
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81263069
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77003360
22RACK7_27058665_Chip-Seq_MCF-7_Human1.73063386
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68579664
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68157423
25ATF3_27146783_Chip-Seq_COLON_Human1.68148996
26SOX2_20726797_ChIP-Seq_SW620_Human1.56559458
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.50602918
28KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47062329
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38951241
30RBPJ_21746931_ChIP-Seq_IB4_Human1.38030045
31RXR_22108803_ChIP-Seq_LS180_Human1.36910565
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33986033
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32465617
34* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31552620
35CLOCK_20551151_ChIP-Seq_293T_Human1.30950537
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30782964
37GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.26631817
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25131171
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25011778
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23534398
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23067626
42HTT_18923047_ChIP-ChIP_STHdh_Human1.22470723
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21196564
44* GATA3_24758297_ChIP-Seq_MCF-7_Human1.20709089
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18293481
46* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17139752
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16452887
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.14322185
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14217561
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14217561
51KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14217561
52KLF5_25053715_ChIP-Seq_YYC3_Human1.13469729
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13353984
54* CTCF_20526341_ChIP-Seq_ESCs_Human1.09845924
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09545463
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.08738072
57TP63_23658742_ChIP-Seq_EP156T_Human1.08245064
58TP63_22573176_ChIP-Seq_HFKS_Human1.08037844
59* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07739315
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06819597
61CTCF_27219007_Chip-Seq_Bcells_Human1.05900121
62* CEBPB_22108803_ChIP-Seq_LS180_Human1.05567976
63E2F1_20622854_ChIP-Seq_HELA_Human1.04924995
64* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04293377
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.04078058
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04023576
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03650914
68LXR_22292898_ChIP-Seq_THP-1_Human1.02780932
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01906154
70SA1_27219007_Chip-Seq_Bcells_Human1.01851511
71UBF1/2_26484160_Chip-Seq_HMECs_Human0.99797777
72ERG_20517297_ChIP-Seq_VCAP_Human0.98877622
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98449901
74STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98045858
75AHR_22903824_ChIP-Seq_MCF-7_Human0.97542675
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97327848
77BCOR_27268052_Chip-Seq_Bcells_Human0.96986447
78GATA4_25053715_ChIP-Seq_YYC3_Human0.96953482
79GATA6_25053715_ChIP-Seq_YYC3_Human0.96633186
80* NANOG_20526341_ChIP-Seq_ESCs_Human0.96258908
81BCL6_27268052_Chip-Seq_Bcells_Human0.95101092
82CDX2_20551321_ChIP-Seq_CACO-2_Human0.94581302
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93894774
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92135787
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91887925
86CSB_26484114_Chip-Seq_FIBROBLAST_Human0.91638711
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90615787
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90493217
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.89740432
90P53_21459846_ChIP-Seq_SAOS-2_Human0.89469914
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89431687
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89255236
93CJUN_26792858_Chip-Seq_BT549_Human0.89157087
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89121747
95BP1_19119308_ChIP-ChIP_Hs578T_Human0.88384030
96PHF8_20622854_ChIP-Seq_HELA_Human0.88222960
97SPI1_20517297_ChIP-Seq_HL60_Human0.86426160
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86086734
99MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.85934478
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.85397258
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85072337
102YY1_22570637_ChIP-Seq_MALME-3M_Human0.84134930
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.83879242
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.83775572
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83411742
106FOXH1_21741376_ChIP-Seq_ESCs_Human0.82467645
107GATA1_19941826_ChIP-Seq_K562_Human0.81939941
108HOXB7_26014856_ChIP-Seq_BT474_Human0.81764647
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81328980
110TAF2_19829295_ChIP-Seq_ESCs_Human0.79889008
111KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79885831
112P300_27268052_Chip-Seq_Bcells_Human0.79737347
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79680715
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79171746
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79040829
116AR_21909140_ChIP-Seq_LNCAP_Human0.78843846
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77482111
118EGR1_19032775_ChIP-ChIP_M12_Human0.77419225
119P68_20966046_ChIP-Seq_HELA_Human0.77349672
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77156380
121* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76643452
122GATA2_19941826_ChIP-Seq_K562_Human0.75900490
123* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75898347
124SMC4_20622854_ChIP-Seq_HELA_Human0.75613918
125NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75559483
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75134220
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74724626
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.74654952
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.74584649
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74469670
131CREB1_26743006_Chip-Seq_LNCaP_Human0.74393353
132RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74250006
133* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73950870
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72446080
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72403877
136TP53_18474530_ChIP-ChIP_U2OS_Human0.71512182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.04080957
2MP0000579_abnormal_nail_morphology6.45839499
3MP0005275_abnormal_skin_tensile5.26036562
4MP0005501_abnormal_skin_physiology4.52480492
5MP0004043_abnormal_pH_regulation4.04974974
6MP0000467_abnormal_esophagus_morphology3.98170455
7MP0010234_abnormal_vibrissa_follicle3.72732618
8MP0000383_abnormal_hair_follicle3.20327213
9MP0003941_abnormal_skin_development3.18640749
10MP0003705_abnormal_hypodermis_morpholog3.10785210
11MP0001216_abnormal_epidermal_layer3.05266736
12MP0005377_hearing/vestibular/ear_phenot2.98385900
13MP0003878_abnormal_ear_physiology2.98385900
14MP0002254_reproductive_system_inflammat2.94192584
15MP0000762_abnormal_tongue_morphology2.92882713
16MP0004782_abnormal_surfactant_physiolog2.90909054
17MP0010678_abnormal_skin_adnexa2.86745765
18MP0004885_abnormal_endolymph2.84235941
19MP0002060_abnormal_skin_morphology2.70332593
20MP0003453_abnormal_keratinocyte_physiol2.68318798
21MP0002234_abnormal_pharynx_morphology2.66116009
22MP0010771_integument_phenotype2.65227968
23MP0005451_abnormal_body_composition2.52642820
24MP0003566_abnormal_cell_adhesion2.48901375
25MP0002098_abnormal_vibrissa_morphology2.44135050
26MP0000647_abnormal_sebaceous_gland2.38177250
27MP0000427_abnormal_hair_cycle2.21704459
28MP0004947_skin_inflammation2.15767805
29MP0000377_abnormal_hair_follicle2.13297194
30MP0004381_abnormal_hair_follicle2.10352245
31MP0000566_synostosis1.86927545
32MP0001849_ear_inflammation1.66865252
33MP0009931_abnormal_skin_appearance1.52054313
34MP0010030_abnormal_orbit_morphology1.51423252
35MP0001346_abnormal_lacrimal_gland1.43281710
36MP0001851_eye_inflammation1.38081362
37MP0005409_darkened_coat_color1.34832788
38MP0009053_abnormal_anal_canal1.34587727
39MP0001958_emphysema1.29011879
40MP0010352_gastrointestinal_tract_polyps1.28304851
41MP0000367_abnormal_coat/_hair1.26235283
42MP0004185_abnormal_adipocyte_glucose1.26170861
43MP0003191_abnormal_cellular_cholesterol1.24156224
44MP0005023_abnormal_wound_healing1.22424748
45MP0001243_abnormal_dermal_layer1.17939482
46MP0001191_abnormal_skin_condition1.17063992
47MP0005083_abnormal_biliary_tract1.15354317
48MP0000537_abnormal_urethra_morphology1.09514005
49MP0004264_abnormal_extraembryonic_tissu1.02973316
50MP0008789_abnormal_olfactory_epithelium1.02938218
51MP0000465_gastrointestinal_hemorrhage1.01289726
52MP0008004_abnormal_stomach_pH1.00624753
53MP0002282_abnormal_trachea_morphology0.97959486
54MP0002095_abnormal_skin_pigmentation0.96103284
55MP0001188_hyperpigmentation0.85515490
56MP0000685_abnormal_immune_system0.83451649
57MP0001340_abnormal_eyelid_morphology0.83299418
58MP0000371_diluted_coat_color0.79705550
59MP0009379_abnormal_foot_pigmentation0.74556553
60MP0003755_abnormal_palate_morphology0.73437737
61MP0000470_abnormal_stomach_morphology0.73193644
62MP0006054_spinal_hemorrhage0.71999572
63MP0004272_abnormal_basement_membrane0.71124421
64MP0005503_abnormal_tendon_morphology0.70572007
65MP0003315_abnormal_perineum_morphology0.69635880
66MP0002133_abnormal_respiratory_system0.67782340
67MP0005388_respiratory_system_phenotype0.67782340
68MP0000627_abnormal_mammary_gland0.67236867
69MP0001765_abnormal_ion_homeostasis0.66892550
70MP0009780_abnormal_chondrocyte_physiolo0.66778113
71MP0005670_abnormal_white_adipose0.65231305
72MP0002111_abnormal_tail_morphology0.63429648
73MP0001784_abnormal_fluid_regulation0.60705797
74MP0005499_abnormal_olfactory_system0.59125079
75MP0005394_taste/olfaction_phenotype0.59125079
76MP0005248_abnormal_Harderian_gland0.58219317
77MP0002233_abnormal_nose_morphology0.58213032
78MP0000678_abnormal_parathyroid_gland0.57651591
79MP0005408_hypopigmentation0.56988526
80MP0002249_abnormal_larynx_morphology0.55110202
81MP0001485_abnormal_pinna_reflex0.54800185
82MP0002138_abnormal_hepatobiliary_system0.54442482
83MP0001177_atelectasis0.53034912
84MP0008438_abnormal_cutaneous_collagen0.51745793
85MP0002177_abnormal_outer_ear0.51500649
86MP0005375_adipose_tissue_phenotype0.49515012
87MP0000538_abnormal_urinary_bladder0.48671209
88MP0005076_abnormal_cell_differentiation0.48451270
89MP0002909_abnormal_adrenal_gland0.45147943
90MP0003950_abnormal_plasma_membrane0.43774968
91MP0005193_abnormal_anterior_eye0.42305948
92MP0009333_abnormal_splenocyte_physiolog0.40186088
93MP0000733_abnormal_muscle_development0.39827870
94MP0003937_abnormal_limbs/digits/tail_de0.39732253
95MP0003806_abnormal_nucleotide_metabolis0.39416057
96MP0003011_delayed_dark_adaptation0.38692790
97MP0005636_abnormal_mineral_homeostasis0.38108105
98MP0000516_abnormal_urinary_system0.38009344
99MP0005367_renal/urinary_system_phenotyp0.38009344
100MP0000432_abnormal_head_morphology0.36872506
101MP0002075_abnormal_coat/hair_pigmentati0.36359250
102MP0000462_abnormal_digestive_system0.36213922
103MP0010368_abnormal_lymphatic_system0.36051906
104MP0003385_abnormal_body_wall0.35977977
105MP0003638_abnormal_response/metabolism_0.34992277
106MP0000613_abnormal_salivary_gland0.33834993
107MP0001186_pigmentation_phenotype0.33548653
108MP0004197_abnormal_fetal_growth/weight/0.31992391
109MP0005410_abnormal_fertilization0.31394746
110MP0005666_abnormal_adipose_tissue0.31294060
111MP0004957_abnormal_blastocyst_morpholog0.29181610
112MP0003890_abnormal_embryonic-extraembry0.29026250
113MP0002697_abnormal_eye_size0.27909301
114MP0004019_abnormal_vitamin_homeostasis0.27668922
115MP0009384_cardiac_valve_regurgitation0.27289624
116MP0000343_altered_response_to0.26523902
117MP0000751_myopathy0.25851048
118MP0009785_altered_susceptibility_to0.24738752
119MP0001943_abnormal_respiration0.24177570
120MP0001348_abnormal_lacrimal_gland0.23425684
121MP0009115_abnormal_fat_cell0.20539150
122MP0000003_abnormal_adipose_tissue0.16627693
123MP0000049_abnormal_middle_ear0.16612702
124MP0009643_abnormal_urine_homeostasis0.16568442
125MP0000477_abnormal_intestine_morphology0.12880058
126MP0008260_abnormal_autophagy0.12399874
127MP0002136_abnormal_kidney_physiology0.09377675
128MP0009672_abnormal_birth_weight0.08723989
129MP0001879_abnormal_lymphatic_vessel0.08355295
130MP0003828_pulmonary_edema0.07896743
131MP0002081_perinatal_lethality0.07236556
132MP0005365_abnormal_bile_salt0.07080821

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.14430434
2Thick nail (HP:0001805)7.80837268
3Oral leukoplakia (HP:0002745)7.77243278
4Plantar hyperkeratosis (HP:0007556)7.69398547
5Increased IgE level (HP:0003212)7.08469616
6Palmoplantar hyperkeratosis (HP:0000972)6.96278348
7Fragile nails (HP:0001808)6.92194577
8Milia (HP:0001056)6.67842825
9Palmar hyperkeratosis (HP:0010765)6.56585708
10Pili torti (HP:0003777)5.72173020
11Alopecia of scalp (HP:0002293)5.54235411
12Woolly hair (HP:0002224)5.54065037
13Parakeratosis (HP:0001036)5.45905227
14Hypotrichosis (HP:0001006)5.35650404
15Right ventricular cardiomyopathy (HP:0011663)5.33488044
16Abnormal blistering of the skin (HP:0008066)5.05281280
17Abnormality of the axillary hair (HP:0100134)4.68813613
18Abnormality of secondary sexual hair (HP:0009888)4.68813613
19Conjunctival hamartoma (HP:0100780)4.58609591
20Follicular hyperkeratosis (HP:0007502)4.44489567
21Nail dystrophy (HP:0008404)4.41693620
22Erythroderma (HP:0001019)3.97555253
23Atrophic scars (HP:0001075)3.97168804
24Erythema (HP:0010783)3.90094874
25Absent eyelashes (HP:0000561)3.86635389
26Absent hair (HP:0002298)3.61710939
27Esophageal atresia (HP:0002032)3.60647777
28Abnormal hair laboratory examination (HP:0003328)3.46988108
29Congenital ichthyosiform erythroderma (HP:0007431)3.45871552
30Sparse scalp hair (HP:0002209)3.31939335
31Furrowed tongue (HP:0000221)3.29936886
32Brittle hair (HP:0002299)3.29269462
33Laryngomalacia (HP:0001601)3.26090777
34Amniotic constriction ring (HP:0009775)3.19920113
35Abnormality of placental membranes (HP:0011409)3.19920113
36Palmoplantar keratoderma (HP:0000982)3.19652700
37Ridged nail (HP:0001807)3.06895645
38Interstitial pulmonary disease (HP:0006530)3.04774679
39Ectropion (HP:0000656)3.03537529
40Autoamputation (HP:0001218)2.99840377
41Gangrene (HP:0100758)2.96393342
42Corneal erosion (HP:0200020)2.82665604
43Villous atrophy (HP:0011473)2.81571644
44Abnormality of small intestinal villus morphology (HP:0011472)2.81571644
45Anonychia (HP:0001798)2.75493524
46Fatigable weakness (HP:0003473)2.73086264
47Abnormality of the neuromuscular junction (HP:0003398)2.73086264
48Hamartoma of the eye (HP:0010568)2.69707026
49Urticaria (HP:0001025)2.61989775
50Lip pit (HP:0100267)2.61870913
51Curly hair (HP:0002212)2.53161703
52Hyperactive renin-angiotensin system (HP:0000841)2.52988867
53Hyperhidrosis (HP:0000975)2.50235005
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44297960
55Bronchomalacia (HP:0002780)2.43655841
56Blepharitis (HP:0000498)2.41300196
57Sparse eyelashes (HP:0000653)2.39750094
58Hyperkalemia (HP:0002153)2.32561187
59Verrucae (HP:0200043)2.31734453
60Papilloma (HP:0012740)2.31734453
61Nasal polyposis (HP:0100582)2.31710561
62Hypohidrosis (HP:0000966)2.26470181
63Recurrent corneal erosions (HP:0000495)2.22483180
64Advanced eruption of teeth (HP:0006288)2.22137962
65Ventricular tachycardia (HP:0004756)2.22020789
66Corneal dystrophy (HP:0001131)2.18863032
67Pruritus (HP:0000989)2.18241736
68Hypoplastic labia majora (HP:0000059)2.15846826
69Multifactorial inheritance (HP:0001426)2.13997151
70Natal tooth (HP:0000695)2.06033531
71Aplasia cutis congenita (HP:0001057)2.04473936
72Chronic bronchitis (HP:0004469)2.03912058
73Seborrheic dermatitis (HP:0001051)2.01613123
74Abnormality of the fingernails (HP:0001231)2.00654813
75Abnormality of nail color (HP:0100643)10.7047134
76Hypoplasia of dental enamel (HP:0006297)1.96626676
77Abnormality of the labia majora (HP:0012881)1.94045606
78Distal lower limb muscle weakness (HP:0009053)1.93124302
79Carious teeth (HP:0000670)1.92383975
80Abnormality of the nasal mucosa (HP:0000433)1.90414443
81Skin ulcer (HP:0200042)1.88877645
82Fine hair (HP:0002213)1.88800466
83Eczematoid dermatitis (HP:0000976)1.88191737
84Fragile skin (HP:0001030)1.81730161
85Acanthosis nigricans (HP:0000956)1.81706161
86Abnormality of the salivary glands (HP:0010286)1.79093531
87Gastrointestinal atresia (HP:0002589)1.78541121
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.78327230
89Oligodontia (HP:0000677)1.78091005
90Hypergammaglobulinemia (HP:0010702)1.77527777
91Lack of skin elasticity (HP:0100679)1.77217167
92Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.75966820
93Unilateral renal agenesis (HP:0000122)1.73796861
94Muscle fiber splitting (HP:0003555)1.71191815
95Dry skin (HP:0000958)1.70200395
96Exercise-induced muscle cramps (HP:0003710)1.69855401
97Muscle fiber inclusion bodies (HP:0100299)1.69205304
98Ulnar deviation of the wrist (HP:0003049)1.67629743
99Nemaline bodies (HP:0003798)1.67362952
100Paralysis (HP:0003470)1.66108105
101Abnormality of hair growth rate (HP:0011363)1.65421092
102Slow-growing hair (HP:0002217)1.65421092
103Dehydration (HP:0001944)1.65122490
104Preauricular skin tag (HP:0000384)1.63761364
105Type 1 muscle fiber predominance (HP:0003803)1.63185589
106Popliteal pterygium (HP:0009756)1.62481716
107Sepsis (HP:0100806)1.62349745
108Pterygium (HP:0001059)1.61494187
109Hypoplastic toenails (HP:0001800)1.60999749
110Increased connective tissue (HP:0009025)1.60481999
111Myopathic facies (HP:0002058)1.59962254
112Round ear (HP:0100830)1.59867416
113Labial hypoplasia (HP:0000066)1.59353175
114Gout (HP:0001997)1.56920416
115Trismus (HP:0000211)1.55972227
116Cystic hygroma (HP:0000476)1.55448933
117Tubulointerstitial fibrosis (HP:0005576)1.51956252
118Ventricular fibrillation (HP:0001663)1.51376936
119Hypoplastic female external genitalia (HP:0012815)1.50872623
120Sudden death (HP:0001699)1.50173696
121Dry hair (HP:0011359)1.49445386
122Melanocytic nevus (HP:0000995)1.48842555
123Abnormality of the 2nd finger (HP:0004100)1.47914669
124Ulnar bowing (HP:0003031)1.47639770
125Megalencephaly (HP:0001355)1.47515174
126Hyporeflexia of lower limbs (HP:0002600)1.45889856
127Abnormality of the aortic arch (HP:0012303)1.45257089
128Distal arthrogryposis (HP:0005684)1.43853220
129Neck muscle weakness (HP:0000467)1.43841197
130Abnormality of chloride homeostasis (HP:0011422)1.43234094
131Skin pits (HP:0100276)1.41755249
132Pustule (HP:0200039)1.41376771
133Split foot (HP:0001839)1.40084582
134Decreased circulating renin level (HP:0003351)1.39870626
135Skin tags (HP:0010609)1.39632285
136Stenosis of the external auditory canal (HP:0000402)1.38985577
137Keratoconjunctivitis (HP:0001096)1.38980597
138Recurrent bacterial skin infections (HP:0005406)1.38377357
139Abnormality of the gastric mucosa (HP:0004295)1.36513353
140Keratoconjunctivitis sicca (HP:0001097)1.32846800
141Achilles tendon contracture (HP:0001771)1.31847407
142Selective tooth agenesis (HP:0001592)1.31316857
143Renal salt wasting (HP:0000127)1.31261444
144Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.31151545
145Calcaneovalgus deformity (HP:0001848)1.30991348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.00347205
2TRIB33.92695820
3PKN23.55199322
4FER3.35445437
5LRRK23.01511148
6MST1R2.87862788
7PBK2.82320967
8STK242.64683163
9LATS12.51069407
10MAP3K32.30555403
11LATS22.21428174
12TTN2.16831361
13ERBB32.10143698
14NEK92.09450254
15FGFR12.09101422
16WNK12.01533378
17RPS6KA41.93371215
18MAP3K91.87035900
19ILK1.85445764
20TGFBR11.84255657
21ERN11.81984146
22TGFBR21.79330353
23EPHB21.78947845
24PAK41.77652439
25TYRO31.74775380
26PIK3CG1.72400383
27MAPKAPK31.71717453
28PTK21.71506429
29TESK11.66609660
30GRK61.61427657
31RPS6KB21.54619097
32TRPM71.52087770
33FGFR21.49899087
34MAP2K61.47072882
35EPHB11.44085760
36TIE11.38609427
37MAP3K21.37765442
38STK101.28577586
39LMTK21.26965688
40PTK61.23980118
41MET1.23728184
42CAMK1G1.23330253
43WNK41.17043092
44TAOK11.14075135
45CDK121.13897435
46CAMK1D1.13700383
47NME11.13376057
48MARK21.09618636
49IRAK11.06325945
50SGK4941.06189414
51SGK2231.06189414
52MAP3K11.04082494
53STK38L1.01152310
54MST40.96540610
55OBSCN0.93907087
56LIMK10.93295941
57DDR20.88334259
58CDK60.86263583
59ERBB20.82884129
60FGFR30.82749551
61CDC70.82589601
62STK390.82460610
63PHKG10.82303081
64PHKG20.82303081
65EPHA30.77407021
66BLK0.76807122
67KSR20.76707243
68STK380.76679093
69PLK40.76312675
70PIK3CA0.75954883
71MAP3K110.74567866
72ZAP700.74413234
73MAP3K120.72981779
74MAP2K10.71320482
75MAP3K80.70419935
76MAP3K70.69875689
77STK30.67969092
78PDGFRB0.67599259
79PDK20.65683578
80SGK30.65120927
81MATK0.62882100
82DYRK30.60290484
83JAK30.60169261
84MYLK0.59689106
85BMX0.57236849
86RPS6KB10.56414206
87MAP3K60.56104507
88BCR0.54653009
89FGR0.53493874
90TTK0.52507936
91MTOR0.51534161
92FGFR40.51290083
93CDK190.50125184
94MAPKAPK20.49702078
95PRKD10.47924888
96SGK20.47898480
97NEK20.47629414
98PRKAA20.46034763
99DYRK1B0.45580043
100EGFR0.42868346
101ABL20.42842837
102RPS6KA10.41656214
103PIM20.40819434
104MAP2K30.38346853
105SGK10.36851310
106PRKCI0.35742329
107KDR0.34716780
108TYK20.31776745
109NEK60.31533941
110ROCK20.31049023
111DAPK20.30900595
112NEK10.30679875
113SRC0.30544278
114IKBKB0.30167225
115AURKB0.29709787
116PDK30.29309518
117PDK40.29309518
118CDK90.29066053
119ACVR1B0.28213958
120ICK0.27655593
121AKT20.27336421
122SIK30.27013119
123CSK0.26914405
124NLK0.26539843
125PDGFRA0.26487412
126IRAK20.26133254
127RET0.25792118
128FLT30.25332599
129CDC42BPA0.25269573
130ATM0.23273975
131TBK10.23209697
132ABL10.22021422
133RIPK10.21669230
134MKNK10.21067870
135MAPK70.19093879
136BTK0.18958224
137KSR10.18927763
138CDK70.18163880
139DMPK0.17635036
140GSK3A0.16611186
141STK40.13799420
142MINK10.13309376

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.07147252
2Ribosome_Homo sapiens_hsa030102.96963409
3Phenylalanine metabolism_Homo sapiens_hsa003602.92876816
4ECM-receptor interaction_Homo sapiens_hsa045122.88040206
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.76563555
6Chemical carcinogenesis_Homo sapiens_hsa052042.74942209
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.63892185
8Basal cell carcinoma_Homo sapiens_hsa052172.24577529
9Glutathione metabolism_Homo sapiens_hsa004802.23573074
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20190596
11Circadian rhythm_Homo sapiens_hsa047102.16098348
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07738191
13Adherens junction_Homo sapiens_hsa045202.03841499
14Arachidonic acid metabolism_Homo sapiens_hsa005902.02808395
15Linoleic acid metabolism_Homo sapiens_hsa005911.92840357
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91491893
17Histidine metabolism_Homo sapiens_hsa003401.86692664
18Caffeine metabolism_Homo sapiens_hsa002321.84345270
19Hippo signaling pathway_Homo sapiens_hsa043901.80076117
20Tight junction_Homo sapiens_hsa045301.73771590
21Tyrosine metabolism_Homo sapiens_hsa003501.67969244
22Ovarian steroidogenesis_Homo sapiens_hsa049131.61342598
23Fatty acid elongation_Homo sapiens_hsa000621.58438818
24Bladder cancer_Homo sapiens_hsa052191.57786196
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56877935
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.54688697
27Thyroid cancer_Homo sapiens_hsa052161.51684797
28Vascular smooth muscle contraction_Homo sapiens_hsa042701.50827703
29Hedgehog signaling pathway_Homo sapiens_hsa043401.47181116
30Ether lipid metabolism_Homo sapiens_hsa005651.46031596
31VEGF signaling pathway_Homo sapiens_hsa043701.45944855
32Serotonergic synapse_Homo sapiens_hsa047261.45351405
33Salivary secretion_Homo sapiens_hsa049701.44680410
34Proteoglycans in cancer_Homo sapiens_hsa052051.44647166
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43402324
36Proteasome_Homo sapiens_hsa030501.40825628
37Long-term depression_Homo sapiens_hsa047301.39580361
38Steroid biosynthesis_Homo sapiens_hsa001001.36392739
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35947211
40Focal adhesion_Homo sapiens_hsa045101.28144373
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.25386807
42Choline metabolism in cancer_Homo sapiens_hsa052311.24827310
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.23369357
44Base excision repair_Homo sapiens_hsa034101.22764840
45Acute myeloid leukemia_Homo sapiens_hsa052211.22380900
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.21551511
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.16758193
48Amoebiasis_Homo sapiens_hsa051461.15233714
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14812925
50Melanogenesis_Homo sapiens_hsa049161.11318875
51Arginine biosynthesis_Homo sapiens_hsa002201.03673881
52Fat digestion and absorption_Homo sapiens_hsa049751.03388549
53Small cell lung cancer_Homo sapiens_hsa052221.01342931
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97977038
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97120531
56p53 signaling pathway_Homo sapiens_hsa041150.96631677
57TGF-beta signaling pathway_Homo sapiens_hsa043500.95353832
58Malaria_Homo sapiens_hsa051440.89162932
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86087829
60Pertussis_Homo sapiens_hsa051330.85879147
61Phototransduction_Homo sapiens_hsa047440.85653041
62Mismatch repair_Homo sapiens_hsa034300.85503799
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84283037
64Toxoplasmosis_Homo sapiens_hsa051450.83227788
65Renal cell carcinoma_Homo sapiens_hsa052110.81297367
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79570345
67GnRH signaling pathway_Homo sapiens_hsa049120.78699217
68Endocytosis_Homo sapiens_hsa041440.78520356
69Insulin signaling pathway_Homo sapiens_hsa049100.76284933
70Fatty acid biosynthesis_Homo sapiens_hsa000610.76237388
71Mineral absorption_Homo sapiens_hsa049780.74476143
72Fructose and mannose metabolism_Homo sapiens_hsa000510.74129251
73Endometrial cancer_Homo sapiens_hsa052130.73468544
74Dorso-ventral axis formation_Homo sapiens_hsa043200.72202428
75MicroRNAs in cancer_Homo sapiens_hsa052060.72195674
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72184079
77Dilated cardiomyopathy_Homo sapiens_hsa054140.71878885
78Glioma_Homo sapiens_hsa052140.71137674
79Renin secretion_Homo sapiens_hsa049240.70980666
80Notch signaling pathway_Homo sapiens_hsa043300.69093035
81Platelet activation_Homo sapiens_hsa046110.68672035
82Vibrio cholerae infection_Homo sapiens_hsa051100.68465973
83Salmonella infection_Homo sapiens_hsa051320.67745850
84Sphingolipid metabolism_Homo sapiens_hsa006000.67545554
85Phagosome_Homo sapiens_hsa041450.66111994
86HIF-1 signaling pathway_Homo sapiens_hsa040660.63884802
87Pathways in cancer_Homo sapiens_hsa052000.63073580
88Folate biosynthesis_Homo sapiens_hsa007900.62441837
89Glucagon signaling pathway_Homo sapiens_hsa049220.58365952
90PPAR signaling pathway_Homo sapiens_hsa033200.57682877
91Rap1 signaling pathway_Homo sapiens_hsa040150.57139075
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.56233421
93Gastric acid secretion_Homo sapiens_hsa049710.54257330
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53916464
95Arginine and proline metabolism_Homo sapiens_hsa003300.53169189
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.52840845
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51329743
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50835572
99Long-term potentiation_Homo sapiens_hsa047200.50664547
100Melanoma_Homo sapiens_hsa052180.50558774
101Apoptosis_Homo sapiens_hsa042100.50545765
102Axon guidance_Homo sapiens_hsa043600.50173961
103Inositol phosphate metabolism_Homo sapiens_hsa005620.49336852
104Biosynthesis of amino acids_Homo sapiens_hsa012300.49332149
105beta-Alanine metabolism_Homo sapiens_hsa004100.48138048
106Shigellosis_Homo sapiens_hsa051310.46613020
107Pancreatic secretion_Homo sapiens_hsa049720.46147006
108Sulfur metabolism_Homo sapiens_hsa009200.45813776
109Hepatitis C_Homo sapiens_hsa051600.45725806
110Wnt signaling pathway_Homo sapiens_hsa043100.44339064
111Influenza A_Homo sapiens_hsa051640.42802268
112ErbB signaling pathway_Homo sapiens_hsa040120.42357634
113Pancreatic cancer_Homo sapiens_hsa052120.42032975
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.40945455
115Insulin resistance_Homo sapiens_hsa049310.40213059
116DNA replication_Homo sapiens_hsa030300.39919624
117Staphylococcus aureus infection_Homo sapiens_hsa051500.39708964
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38041224
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37505687
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36720472
121Galactose metabolism_Homo sapiens_hsa000520.35987450
122Sulfur relay system_Homo sapiens_hsa041220.35888393
123Oxytocin signaling pathway_Homo sapiens_hsa049210.35671290
124Oocyte meiosis_Homo sapiens_hsa041140.35668442
125Ras signaling pathway_Homo sapiens_hsa040140.35288907
126MAPK signaling pathway_Homo sapiens_hsa040100.33325226
127Estrogen signaling pathway_Homo sapiens_hsa049150.33312695
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33050867
129HTLV-I infection_Homo sapiens_hsa051660.32738617
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.32348356
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.31889284
132Retinol metabolism_Homo sapiens_hsa008300.30966715
133Collecting duct acid secretion_Homo sapiens_hsa049660.30322737
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29406550
135Olfactory transduction_Homo sapiens_hsa047400.26674829
136Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24420395
137Fatty acid degradation_Homo sapiens_hsa000710.23198799
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22996602
139Starch and sucrose metabolism_Homo sapiens_hsa005000.22657502
140Chronic myeloid leukemia_Homo sapiens_hsa052200.22495805
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22205105
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21121710

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