KLK14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kallikrein subfamily of serine proteases that have diverse physiological functions such as regulation of blood pressure and desquamation. The altered expression of this gene is implicated in the progression of different cancers including breast and prostate tumors. The encoded protein is a precursor that is proteolytically processed to generate the functional enzyme. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)6.52885143
2regulation of Golgi to plasma membrane protein transport (GO:0042996)5.39348068
3microtubule severing (GO:0051013)5.34485335
4embryonic heart tube development (GO:0035050)5.28442465
5keratinocyte differentiation (GO:0030216)5.25096817
6negative regulation of synaptic transmission, GABAergic (GO:0032229)5.10653202
7monoubiquitinated protein deubiquitination (GO:0035520)5.09658947
8multicellular organismal water homeostasis (GO:0050891)4.87373134
9presynaptic membrane assembly (GO:0097105)4.66420442
10keratinocyte proliferation (GO:0043616)4.65542815
11epidermis development (GO:0008544)4.49071471
12hair cycle (GO:0042633)4.25018421
13molting cycle (GO:0042303)4.25018421
14response to pheromone (GO:0019236)4.24580421
15long-chain fatty acid biosynthetic process (GO:0042759)4.23422656
16embryonic viscerocranium morphogenesis (GO:0048703)4.21681537
17presynaptic membrane organization (GO:0097090)4.19929759
18postsynaptic membrane organization (GO:0001941)4.19314291
19G-protein coupled receptor internalization (GO:0002031)4.14984666
20water homeostasis (GO:0030104)4.14638208
21epidermal cell differentiation (GO:0009913)3.96875212
22nuclear envelope reassembly (GO:0031468)3.91091683
23mitotic nuclear envelope reassembly (GO:0007084)3.91091683
24histone deubiquitination (GO:0016578)3.82684773
25positive regulation of protein kinase C signaling (GO:0090037)3.80869432
26import into cell (GO:0098657)3.80382004
27keratinocyte development (GO:0003334)3.78369593
28negative regulation of transcription by competitive promoter binding (GO:0010944)3.71832838
29righting reflex (GO:0060013)3.71650235
30apical protein localization (GO:0045176)3.69250548
31definitive hemopoiesis (GO:0060216)3.68168528
32asymmetric protein localization (GO:0008105)3.65546110
33positive regulation of histone deacetylation (GO:0031065)3.64473117
34negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.62227447
35Golgi transport vesicle coating (GO:0048200)3.52601586
36COPI coating of Golgi vesicle (GO:0048205)3.52601586
37embryonic camera-type eye development (GO:0031076)3.52188823
38regulation of cellular senescence (GO:2000772)3.44335707
39neuron cell-cell adhesion (GO:0007158)3.43262641
40cellular response to epinephrine stimulus (GO:0071872)3.39378994
41positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.37013094
42regulation of meiosis I (GO:0060631)3.36894911
43epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33043396
44protein targeting to vacuole (GO:0006623)3.32710434
45protein targeting to lysosome (GO:0006622)3.32710434
46establishment of protein localization to vacuole (GO:0072666)3.32710434
47drinking behavior (GO:0042756)3.30405757
48establishment of apical/basal cell polarity (GO:0035089)3.28566759
49cell-substrate junction assembly (GO:0007044)3.28428662
50linoleic acid metabolic process (GO:0043651)3.22976282
51determination of adult lifespan (GO:0008340)3.22375101
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19256515
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.16703201
54neuronal action potential propagation (GO:0019227)3.15752824
55negative regulation of cardiac muscle hypertrophy (GO:0010614)3.15033420
56entrainment of circadian clock (GO:0009649)3.13715311
57establishment of skin barrier (GO:0061436)3.12507639
58ventricular cardiac muscle cell action potential (GO:0086005)3.12301399
59response to epinephrine (GO:0071871)3.11265927
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.09240753
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07606225
62serotonin receptor signaling pathway (GO:0007210)3.07175674
63sphingoid metabolic process (GO:0046519)3.05081381
64urogenital system development (GO:0001655)3.04672440
65negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.03130488
66poly(A)+ mRNA export from nucleus (GO:0016973)3.03056996
67desmosome organization (GO:0002934)3.01981657
68planar cell polarity pathway involved in neural tube closure (GO:0090179)3.01898262
69negative regulation of erythrocyte differentiation (GO:0045647)3.01877289
70morphogenesis of embryonic epithelium (GO:0016331)3.01610793
71regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.01487060
72left/right pattern formation (GO:0060972)3.01282071
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98369556
74regulation of inositol phosphate biosynthetic process (GO:0010919)2.96881443
75establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.96504319
76mitochondrion transport along microtubule (GO:0047497)2.96504319
77negative regulation of granulocyte differentiation (GO:0030853)2.96145629
78chemosensory behavior (GO:0007635)2.94687195
79hepatocyte differentiation (GO:0070365)2.93772136
80polarized epithelial cell differentiation (GO:0030859)2.93248792
81entrainment of circadian clock by photoperiod (GO:0043153)2.91851332
82lipoxygenase pathway (GO:0019372)2.91087048
83circadian regulation of gene expression (GO:0032922)2.90747041
84dendritic spine organization (GO:0097061)2.90612054
85acrosome reaction (GO:0007340)2.89861396
86superoxide anion generation (GO:0042554)2.89558464
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89511826
88dopamine biosynthetic process (GO:0042416)2.89200820
89vocalization behavior (GO:0071625)2.87606298
90negative regulation of muscle hypertrophy (GO:0014741)2.87252471
91positive regulation of action potential (GO:0045760)2.87052349
92regulation of dopamine secretion (GO:0014059)2.86694418
93startle response (GO:0001964)2.85887930
94glutamate receptor signaling pathway (GO:0007215)2.85740363
95peptide cross-linking (GO:0018149)2.85413275
96rRNA methylation (GO:0031167)2.84654257
97semaphorin-plexin signaling pathway (GO:0071526)2.80602152
98germinal center formation (GO:0002467)2.79109798
99regulation of timing of cell differentiation (GO:0048505)2.76525528
100regulation of nitric-oxide synthase activity (GO:0050999)2.75875733
101face development (GO:0060324)2.74695017
102positive regulation of myotube differentiation (GO:0010831)2.73556252
103spliceosomal tri-snRNP complex assembly (GO:0000244)2.73110761
104negative regulation of neurotransmitter transport (GO:0051589)2.72379117
105negative regulation of Rho protein signal transduction (GO:0035024)2.72334155
106short-term memory (GO:0007614)2.72173677
107interkinetic nuclear migration (GO:0022027)2.71993332
108positive regulation of epidermis development (GO:0045684)2.71741519
109adult feeding behavior (GO:0008343)2.70572456
110adherens junction organization (GO:0034332)2.70165687
111reflex (GO:0060004)2.68802193
112positive regulation of epidermal cell differentiation (GO:0045606)2.68710757
113negative regulation of cell size (GO:0045792)2.68130031
114regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.68013018
115nitric oxide metabolic process (GO:0046209)2.67476321
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.67400427
117regulation of water loss via skin (GO:0033561)2.65075238
118establishment or maintenance of monopolar cell polarity (GO:0061339)2.64381673
119establishment of monopolar cell polarity (GO:0061162)2.64381673
120synaptic vesicle endocytosis (GO:0048488)2.64325346
121intermediate filament cytoskeleton organization (GO:0045104)2.63031213
122skin morphogenesis (GO:0043589)2.62185771
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.61038221
124segment specification (GO:0007379)2.60510053
125thyroid gland development (GO:0030878)2.60320300
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59292697
127glutathione biosynthetic process (GO:0006750)2.58534999
128establishment of mitochondrion localization (GO:0051654)2.58496242
129positive regulation of keratinocyte differentiation (GO:0045618)2.58321930
130neuron-neuron synaptic transmission (GO:0007270)2.57373177
131sensory perception of smell (GO:0007608)2.56791825
132histone H4 deacetylation (GO:0070933)2.56674599
133bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56031651
134limb bud formation (GO:0060174)2.55017949
135DNA double-strand break processing (GO:0000729)2.54492435
136positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.54079302
137neuron recognition (GO:0008038)2.54019238
138cyclic nucleotide catabolic process (GO:0009214)2.53675752
139protein retention in ER lumen (GO:0006621)2.53448866
140mesenchymal cell differentiation involved in renal system development (GO:2001012)2.52592727
141mesenchymal cell differentiation involved in kidney development (GO:0072161)2.52592727
142phagosome maturation (GO:0090382)2.52398559
143calcium ion import (GO:0070509)2.51653130
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51433260
145vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51406272
146sarcoplasmic reticulum calcium ion transport (GO:0070296)2.50412635
147cartilage condensation (GO:0001502)2.50298744
148cell aggregation (GO:0098743)2.50298744
149cranial nerve morphogenesis (GO:0021602)2.49920314
150protein localization to synapse (GO:0035418)2.49724492
151regulation of glutamate receptor signaling pathway (GO:1900449)2.49052616
152cAMP catabolic process (GO:0006198)2.45948455
153negative regulation of synaptic transmission (GO:0050805)2.44344854
154regulation of neuron projection regeneration (GO:0070570)2.43038518
155regulation of axon regeneration (GO:0048679)2.43038518
156appendage development (GO:0048736)2.41601836
157limb development (GO:0060173)2.41601836
158regulation of synaptic transmission, GABAergic (GO:0032228)2.41577785
159detection of bacterium (GO:0016045)2.38718749
160detection of other organism (GO:0098543)2.36803639
161glucosamine-containing compound catabolic process (GO:1901072)2.35540354
162cell wall macromolecule metabolic process (GO:0044036)2.32183842
163cell wall macromolecule catabolic process (GO:0016998)2.32183842
164opioid receptor signaling pathway (GO:0038003)2.32066853
165response to histamine (GO:0034776)2.32021813
166positive regulation of monocyte chemotaxis (GO:0090026)2.31632870
167L-amino acid import (GO:0043092)2.31400785
168positive regulation of hair cycle (GO:0042635)2.30173419
169positive regulation of hair follicle development (GO:0051798)2.30173419
170cellular response to ATP (GO:0071318)2.26198763
171cerebral cortex radially oriented cell migration (GO:0021799)2.25251147
172cilium movement (GO:0003341)2.24846011
173response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.24556357
174transmission of nerve impulse (GO:0019226)2.24484739
175regulation of development, heterochronic (GO:0040034)2.23860614
176otic vesicle formation (GO:0030916)2.22883992
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21728052
178axonal fasciculation (GO:0007413)2.20963449
179intermediate filament organization (GO:0045109)2.20896493
180regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.20882971
181positive regulation of protein sumoylation (GO:0033235)2.20576359
182negative regulation of keratinocyte proliferation (GO:0010839)2.18282400
183positive regulation of synapse assembly (GO:0051965)2.17104256
184regulation of heart rate by cardiac conduction (GO:0086091)2.16879596
185neuron remodeling (GO:0016322)2.16593969
186hemidesmosome assembly (GO:0031581)2.16195538
187response to cocaine (GO:0042220)2.16015695

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88024829
2GBX2_23144817_ChIP-Seq_PC3_Human3.74575564
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40293209
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.25322089
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.05034673
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73982423
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.69416345
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60282995
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50808475
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.43019704
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.42965437
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.42133212
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38379223
14RACK7_27058665_Chip-Seq_MCF-7_Human2.34976502
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33035194
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31683859
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29225807
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28412676
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28225567
20VDR_22108803_ChIP-Seq_LS180_Human2.25905826
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.24911593
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24406291
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24297144
24ZNF263_19887448_ChIP-Seq_K562_Human2.22763073
25SCL_19346495_ChIP-Seq_HPC-7_Human2.21614535
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21602278
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21533220
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21533220
29P63_26484246_Chip-Seq_KERATINOCYTES_Human2.20752437
30RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16145105
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12097657
32LXR_22292898_ChIP-Seq_THP-1_Human2.08173745
33MYC_22102868_ChIP-Seq_BL_Human2.07512389
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07112353
35DNAJC2_21179169_ChIP-ChIP_NT2_Human2.04837789
36CBX2_27304074_Chip-Seq_ESCs_Mouse2.03738792
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00007312
38KDM2B_26808549_Chip-Seq_DND41_Human1.99778445
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.98460124
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97462142
41TAF15_26573619_Chip-Seq_HEK293_Human1.94951786
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94468375
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91844488
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91559377
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90975299
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.89644040
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88931175
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.86631943
49TCF7_22412390_ChIP-Seq_EML_Mouse1.84008278
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.83961368
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.82571075
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.77556876
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75355869
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.72940871
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71057963
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.67936063
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65294813
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64817947
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64770066
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61576381
61KDM2B_26808549_Chip-Seq_K562_Human1.60356349
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60143371
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59050719
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58387710
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55106357
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54833999
67KLF5_25053715_ChIP-Seq_YYC3_Human1.53387645
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53164205
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.51268888
70P300_19829295_ChIP-Seq_ESCs_Human1.50826976
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50665126
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50407454
73CREB1_26743006_Chip-Seq_LNCaP_Human1.49233600
74P68_20966046_ChIP-Seq_HELA_Human1.47645986
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45845921
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45701498
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45701498
78SMC4_20622854_ChIP-Seq_HELA_Human1.44482277
79TP53_18474530_ChIP-ChIP_U2OS_Human1.43929747
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43865050
81AR_21572438_ChIP-Seq_LNCaP_Human1.41869109
82SMAD4_21799915_ChIP-Seq_A2780_Human1.40949405
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.39060609
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.38898578
85REST_21632747_ChIP-Seq_MESCs_Mouse1.38689221
86RNF2_27304074_Chip-Seq_NSC_Mouse1.37696795
87DROSHA_22980978_ChIP-Seq_HELA_Human1.36024093
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35887518
89TP63_22573176_ChIP-Seq_HFKS_Human1.35443122
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35197378
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.35047988
92ATF3_27146783_Chip-Seq_COLON_Human1.34611029
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.33004392
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32605705
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.32568157
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32240067
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29935942
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.27724658
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.27593076
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.27526346
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27345239
102P53_22387025_ChIP-Seq_ESCs_Mouse1.26953228
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.26626778
104EGR1_19032775_ChIP-ChIP_M12_Human1.26276068
105VDR_21846776_ChIP-Seq_THP-1_Human1.24287791
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23840318
107SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22957150
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22289993
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22273524
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21673097
111CLOCK_20551151_ChIP-Seq_293T_Human1.21672430
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21345512
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21272570
114SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20723111
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.20697336
116CTCF_27219007_Chip-Seq_Bcells_Human1.20548130
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18544179
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17225766
119GATA6_25053715_ChIP-Seq_YYC3_Human1.17072442
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.16850265
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.15512297
122P300_18555785_Chip-Seq_ESCs_Mouse1.15488194
123FUS_26573619_Chip-Seq_HEK293_Human1.14372189
124AHR_22903824_ChIP-Seq_MCF-7_Human1.14219527
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12655385
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12135495
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11298366
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.11030992
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10873035
130ARNT_22903824_ChIP-Seq_MCF-7_Human1.10094119
131ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10009290
132STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09527941
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08605231
134SOX2_18555785_Chip-Seq_ESCs_Mouse1.08276799
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06651615
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06008121
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05798244
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05049768
139SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04274050
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04081611
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03196875
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03170059
143RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03154568
144RUNX2_22187159_ChIP-Seq_PCA_Human1.02564481
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01885880
146RARB_24833708_ChIP-Seq_LIVER_Mouse1.01762380
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.01655861
148IGF1R_20145208_ChIP-Seq_DFB_Human1.01420874
149AR_25329375_ChIP-Seq_VCAP_Human1.01197332
150STAT3_23295773_ChIP-Seq_U87_Human1.01171185
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01118329
152NMYC_18555785_Chip-Seq_ESCs_Mouse1.01103051
153TP53_16413492_ChIP-PET_HCT116_Human1.00616077
154BCOR_27268052_Chip-Seq_Bcells_Human1.00090233
155ER_23166858_ChIP-Seq_MCF-7_Human0.99816808
156NCOR1_26117541_ChIP-Seq_K562_Human0.99737131
157TCF4_23295773_ChIP-Seq_U87_Human0.99633533
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.99517089
159KDM2B_26808549_Chip-Seq_REH_Human0.99401925
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.98986378
161PHF8_20622854_ChIP-Seq_HELA_Human0.98979903
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98846332
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97295483
164KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97295483
165KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97295483
166BCAT_22108803_ChIP-Seq_LS180_Human0.97194866
167* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96960503
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96840137
169KDM2B_26808549_Chip-Seq_JURKAT_Human0.95755364
170KLF4_18555785_Chip-Seq_ESCs_Mouse0.95693959
171PU1_27457419_Chip-Seq_LIVER_Mouse0.95362878
172VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94879999
173PRDM14_20953172_ChIP-Seq_ESCs_Human0.94835595
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93898809
175NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93684092
176SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93275051
177PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93106347
178BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91985405
179MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91409987
180E2F1_20622854_ChIP-Seq_HELA_Human0.91409770
181UBF1/2_26484160_Chip-Seq_HMECs_Human0.91176785
182BCL6_27268052_Chip-Seq_Bcells_Human0.91128595
183CTCF_18555785_Chip-Seq_ESCs_Mouse0.90768821
184SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89755166
185SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87473480
186SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85930935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color3.33971573
2MP0003880_abnormal_central_pattern3.29125933
3MP0003136_yellow_coat_color3.27432850
4MP0004381_abnormal_hair_follicle3.22788245
5MP0010234_abnormal_vibrissa_follicle3.21654870
6MP0000579_abnormal_nail_morphology3.21548192
7MP0004264_abnormal_extraembryonic_tissu3.07164801
8MP0001188_hyperpigmentation3.05972746
9MP0005275_abnormal_skin_tensile2.80140028
10MP0010678_abnormal_skin_adnexa2.71189500
11MP0003453_abnormal_keratinocyte_physiol2.70338115
12MP0002098_abnormal_vibrissa_morphology2.69815054
13MP0003705_abnormal_hypodermis_morpholog2.65090040
14MP0002138_abnormal_hepatobiliary_system2.59595173
15MP0002102_abnormal_ear_morphology2.58923263
16MP0000467_abnormal_esophagus_morphology2.43549113
17MP0001216_abnormal_epidermal_layer2.33757116
18MP0001486_abnormal_startle_reflex2.30583760
19MP0009046_muscle_twitch2.20505302
20MP0005666_abnormal_adipose_tissue2.19827120
21MP0002735_abnormal_chemical_nociception2.15783255
22MP0004742_abnormal_vestibular_system2.08029141
23MP0010352_gastrointestinal_tract_polyps2.03777826
24MP0000762_abnormal_tongue_morphology2.03744423
25MP0009745_abnormal_behavioral_response2.01066349
26MP0003283_abnormal_digestive_organ1.97866854
27MP0001501_abnormal_sleep_pattern1.97831741
28MP0001440_abnormal_grooming_behavior1.97319984
29MP0002060_abnormal_skin_morphology1.92747474
30MP0003635_abnormal_synaptic_transmissio1.91720233
31MP0004859_abnormal_synaptic_plasticity1.91658517
32MP0003183_abnormal_peptide_metabolism1.91141897
33MP0000566_synostosis1.87685955
34MP0001984_abnormal_olfaction1.79717310
35MP0002277_abnormal_respiratory_mucosa1.78941387
36MP0001905_abnormal_dopamine_level1.77858301
37MP0005248_abnormal_Harderian_gland1.77123795
38MP0000377_abnormal_hair_follicle1.76083896
39MP0002064_seizures1.74882244
40MP0004142_abnormal_muscle_tone1.71814497
41MP0002796_impaired_skin_barrier1.70778559
42MP0001346_abnormal_lacrimal_gland1.70322218
43MP0004185_abnormal_adipocyte_glucose1.63446737
44MP0001968_abnormal_touch/_nociception1.61185256
45MP0005375_adipose_tissue_phenotype1.59518137
46MP0002734_abnormal_mechanical_nocicepti1.59157378
47MP0002572_abnormal_emotion/affect_behav1.58484744
48MP0002736_abnormal_nociception_after1.56029014
49MP0002272_abnormal_nervous_system1.53638509
50MP0003950_abnormal_plasma_membrane1.52413257
51MP0002234_abnormal_pharynx_morphology1.50735315
52MP0005171_absent_coat_pigmentation1.50605891
53MP0000678_abnormal_parathyroid_gland1.49597641
54MP0004270_analgesia1.46340710
55MP0002063_abnormal_learning/memory/cond1.44675303
56MP0009931_abnormal_skin_appearance1.43017686
57MP0002876_abnormal_thyroid_physiology1.41540480
58MP0002067_abnormal_sensory_capabilities1.40249445
59MP0001191_abnormal_skin_condition1.38647394
60MP0000049_abnormal_middle_ear1.38194060
61MP0003315_abnormal_perineum_morphology1.37482432
62MP0006292_abnormal_olfactory_placode1.37406409
63MP0004145_abnormal_muscle_electrophysio1.36390871
64MP0004947_skin_inflammation1.34177586
65MP0005623_abnormal_meninges_morphology1.31991510
66MP0003879_abnormal_hair_cell1.30898367
67MP0002557_abnormal_social/conspecific_i1.30761314
68MP0008789_abnormal_olfactory_epithelium1.29395409
69MP0002184_abnormal_innervation1.28261219
70MP0003566_abnormal_cell_adhesion1.25865735
71MP0002254_reproductive_system_inflammat1.21545672
72MP0005501_abnormal_skin_physiology1.21455755
73MP0002249_abnormal_larynx_morphology1.21267621
74MP0001970_abnormal_pain_threshold1.21185222
75MP0003941_abnormal_skin_development1.20138297
76MP0002111_abnormal_tail_morphology1.19427199
77MP0005499_abnormal_olfactory_system1.19202881
78MP0005394_taste/olfaction_phenotype1.19202881
79MP0005670_abnormal_white_adipose1.19118841
80MP0004043_abnormal_pH_regulation1.17884374
81MP0010386_abnormal_urinary_bladder1.17383866
82MP0003787_abnormal_imprinting1.17206797
83MP0001879_abnormal_lymphatic_vessel1.15307945
84MP0005645_abnormal_hypothalamus_physiol1.14140796
85MP0005551_abnormal_eye_electrophysiolog1.13803944
86MP0000026_abnormal_inner_ear1.09807448
87MP0003724_increased_susceptibility_to1.09584666
88MP0001348_abnormal_lacrimal_gland1.09484540
89MP0004808_abnormal_hematopoietic_stem1.08485027
90MP0001502_abnormal_circadian_rhythm1.08007476
91MP0000013_abnormal_adipose_tissue1.07934360
92MP0004197_abnormal_fetal_growth/weight/1.06911455
93MP0009250_abnormal_appendicular_skeleto1.06219765
94MP0006072_abnormal_retinal_apoptosis1.06156350
95MP0003195_calcinosis1.02933680
96MP0002733_abnormal_thermal_nociception1.02087755
97MP0001963_abnormal_hearing_physiology1.01815971
98MP0001270_distended_abdomen1.01381393
99MP0006138_congestive_heart_failure1.00488081
100MP0000778_abnormal_nervous_system0.99230030
101MP0008961_abnormal_basal_metabolism0.97876884
102MP0004858_abnormal_nervous_system0.96936540
103MP0001664_abnormal_digestion0.96266998
104MP0005367_renal/urinary_system_phenotyp0.94707691
105MP0000516_abnormal_urinary_system0.94707691
106MP0000383_abnormal_hair_follicle0.93592455
107MP0004134_abnormal_chest_morphology0.92256344
108MP0001986_abnormal_taste_sensitivity0.91963985
109MP0000003_abnormal_adipose_tissue0.90232451
110MP0005646_abnormal_pituitary_gland0.89368144
111MP0002837_dystrophic_cardiac_calcinosis0.89359055
112MP0001529_abnormal_vocalization0.88972126
113MP0001784_abnormal_fluid_regulation0.88891343
114MP0004484_altered_response_of0.88757300
115MP0006276_abnormal_autonomic_nervous0.87563023
116MP0000367_abnormal_coat/_hair0.86414331
117MP0001661_extended_life_span0.83764739
118MP0000613_abnormal_salivary_gland0.83614226
119MP0004215_abnormal_myocardial_fiber0.83441162
120MP0005310_abnormal_salivary_gland0.83316265
121MP0004885_abnormal_endolymph0.80065392
122MP0000858_altered_metastatic_potential0.79988220
123MP0001485_abnormal_pinna_reflex0.79775881
124MP0002177_abnormal_outer_ear0.78723987
125MP0003878_abnormal_ear_physiology0.78352107
126MP0005377_hearing/vestibular/ear_phenot0.78352107
127MP0000015_abnormal_ear_pigmentation0.78340581
128MP0000631_abnormal_neuroendocrine_gland0.76282622
129MP0000627_abnormal_mammary_gland0.75562041
130MP0000462_abnormal_digestive_system0.75044605
131MP0010771_integument_phenotype0.74654793
132MP0000681_abnormal_thyroid_gland0.74190576
133MP0000427_abnormal_hair_cycle0.74105893
134MP0002877_abnormal_melanocyte_morpholog0.74074274
135MP0002089_abnormal_postnatal_growth/wei0.73077364
136MP0002066_abnormal_motor_capabilities/c0.72826354
137MP0004782_abnormal_surfactant_physiolog0.72819436
138MP0001849_ear_inflammation0.72660566
139MP0002882_abnormal_neuron_morphology0.71902333
140MP0000920_abnormal_myelination0.71791936
141MP0002332_abnormal_exercise_endurance0.71440985
142MP0001765_abnormal_ion_homeostasis0.70758409
143MP0000647_abnormal_sebaceous_gland0.69828256
144MP0002638_abnormal_pupillary_reflex0.69241423
145MP0003763_abnormal_thymus_physiology0.68887731
146MP0008260_abnormal_autophagy0.65013911
147MP0001340_abnormal_eyelid_morphology0.60926862
148MP0000163_abnormal_cartilage_morphology0.57662063
149MP0003755_abnormal_palate_morphology0.56532061
150MP0010630_abnormal_cardiac_muscle0.55905673
151MP0002116_abnormal_craniofacial_bone0.54653652
152MP0003221_abnormal_cardiomyocyte_apopto0.54554788
153MP0003115_abnormal_respiratory_system0.52929420
154MP0005076_abnormal_cell_differentiation0.52884220
155MP0002932_abnormal_joint_morphology0.51546591
156MP0002114_abnormal_axial_skeleton0.49625390
157MP0000767_abnormal_smooth_muscle0.49556118
158MP0003279_aneurysm0.46739634
159MP0002972_abnormal_cardiac_muscle0.46119815
160MP0000537_abnormal_urethra_morphology0.45950261
161MP0000733_abnormal_muscle_development0.45664028
162MP0000569_abnormal_digit_pigmentation0.44661433
163MP0004084_abnormal_cardiac_muscle0.44490956
164MP0002282_abnormal_trachea_morphology0.44218963
165MP0005023_abnormal_wound_healing0.43993131
166MP0002092_abnormal_eye_morphology0.43356109
167MP0009672_abnormal_birth_weight0.42806675
168MP0002115_abnormal_skeleton_extremities0.42229849

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.05565079
2Focal motor seizures (HP:0011153)4.74039435
3Aplasia cutis congenita (HP:0001057)4.70649768
4Alopecia of scalp (HP:0002293)4.45367890
5Erythema (HP:0010783)4.23607434
6Hypotrichosis (HP:0001006)4.23097584
7Abnormality of nail color (HP:0100643)4.03676914
8Obstructive sleep apnea (HP:0002870)3.95668799
9Distal lower limb amyotrophy (HP:0008944)3.87913654
10Thick nail (HP:0001805)3.77356203
11Erythroderma (HP:0001019)3.72467713
12Tubulointerstitial nephritis (HP:0001970)3.70051977
13Flat acetabular roof (HP:0003180)3.68613735
14Septo-optic dysplasia (HP:0100842)3.56992697
15Hyperkalemia (HP:0002153)3.43329150
16Febrile seizures (HP:0002373)3.30428866
17Aplasia involving bones of the extremities (HP:0009825)3.26913845
18Aplasia involving bones of the upper limbs (HP:0009823)3.26913845
19Aplasia of the phalanges of the hand (HP:0009802)3.26913845
20Conjunctival hamartoma (HP:0100780)3.25949514
21Abnormal ciliary motility (HP:0012262)3.25434169
22Natal tooth (HP:0000695)3.22202439
23Oral leukoplakia (HP:0002745)3.16397828
24Upper limb muscle weakness (HP:0003484)3.12427946
25Nail dystrophy (HP:0008404)3.10654629
26Lower limb amyotrophy (HP:0007210)3.05079210
27Metaphyseal cupping (HP:0003021)2.95867003
28Hamartoma of the eye (HP:0010568)2.95107116
29Ependymoma (HP:0002888)2.89764965
30Abnormality of the salivary glands (HP:0010286)2.89530729
31Lip pit (HP:0100267)2.88225076
32Epileptic encephalopathy (HP:0200134)2.86855487
33Congenital malformation of the right heart (HP:0011723)2.85685973
34Double outlet right ventricle (HP:0001719)2.85685973
35Ridged nail (HP:0001807)2.79101170
36Abnormal blistering of the skin (HP:0008066)2.77936860
37Plantar hyperkeratosis (HP:0007556)2.77767711
38Overfolded helix (HP:0000396)2.77759677
39Nonimmune hydrops fetalis (HP:0001790)2.76458169
40Milia (HP:0001056)2.74653671
41Right ventricular cardiomyopathy (HP:0011663)2.72485753
42Corneal erosion (HP:0200020)2.69746713
43Lymphangioma (HP:0100764)2.68066009
44Pili torti (HP:0003777)2.66824440
45Angiofibromas (HP:0010615)2.64351413
46Adenoma sebaceum (HP:0009720)2.64351413
47Abnormal respiratory motile cilium physiology (HP:0012261)2.64324797
48Absent/shortened dynein arms (HP:0200106)2.62519315
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.62519315
50Palmoplantar hyperkeratosis (HP:0000972)2.58726705
51Fibular aplasia (HP:0002990)2.57004799
52Osteomalacia (HP:0002749)2.56877553
53Nasolacrimal duct obstruction (HP:0000579)2.55174104
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51489966
55Mixed hearing impairment (HP:0000410)2.49102771
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.48650155
57Biliary tract neoplasm (HP:0100574)2.44945355
58Congenital sensorineural hearing impairment (HP:0008527)2.43469110
59Ectropion (HP:0000656)2.42272150
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40019625
61Absent epiphyses (HP:0010577)2.40019625
62Abnormally folded helix (HP:0008544)2.37978046
63Palmar hyperkeratosis (HP:0010765)2.35744544
64Generalized tonic-clonic seizures (HP:0002069)2.32774126
65Palmoplantar keratoderma (HP:0000982)2.31984724
66Back pain (HP:0003418)2.28944063
67Optic nerve hypoplasia (HP:0000609)2.27774554
68Focal seizures (HP:0007359)2.27750974
69J-shaped sella turcica (HP:0002680)2.25820269
70Central scotoma (HP:0000603)2.25522958
71Atonic seizures (HP:0010819)2.24834736
72Absent eyelashes (HP:0000561)2.22783813
73Congenital ichthyosiform erythroderma (HP:0007431)2.22709655
74Lower limb asymmetry (HP:0100559)2.22219629
75Tetany (HP:0001281)2.21173325
76Increased IgE level (HP:0003212)2.20576218
77Pustule (HP:0200039)2.19203180
78Corneal dystrophy (HP:0001131)2.17857107
79Fragile nails (HP:0001808)2.17609589
80Esophageal atresia (HP:0002032)2.16720665
81Round ear (HP:0100830)2.15085604
82Laryngomalacia (HP:0001601)2.14759222
83Distal upper limb amyotrophy (HP:0007149)2.12002276
84Upper limb amyotrophy (HP:0009129)2.12002276
85Decreased central vision (HP:0007663)2.11751635
86Hypohidrosis (HP:0000966)2.11666844
87Exotropia (HP:0000577)2.11396872
88Abnormal respiratory motile cilium morphology (HP:0005938)2.10516317
89Abnormal respiratory epithelium morphology (HP:0012253)2.10516317
90Astrocytoma (HP:0009592)2.09530906
91Abnormality of the astrocytes (HP:0100707)2.09530906
92Asymmetry of the thorax (HP:0001555)2.08899230
93Absent septum pellucidum (HP:0001331)2.08701321
94Absence seizures (HP:0002121)2.08574892
95Thoracic kyphosis (HP:0002942)2.08462492
96Abnormality of the renal medulla (HP:0100957)2.06370664
97Abnormality of the lacrimal duct (HP:0011481)2.06076239
98Broad-based gait (HP:0002136)2.05195552
99Renal cortical cysts (HP:0000803)2.04701021
100White forelock (HP:0002211)2.04636849
101Dialeptic seizures (HP:0011146)2.04407822
102Oligodontia (HP:0000677)2.03134023
103Unilateral renal agenesis (HP:0000122)2.03030958
104Distal lower limb muscle weakness (HP:0009053)2.02718182
105Popliteal pterygium (HP:0009756)2.01661606
106Woolly hair (HP:0002224)2.01147075
107Fibular hypoplasia (HP:0003038)2.00781226
108Slender build (HP:0001533)2.00559636
109Prostate neoplasm (HP:0100787)1.99986100
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99877998
111Spinal cord compression (HP:0002176)1.99595015
112Craniofacial hyperostosis (HP:0004493)1.98357584
113Muscle hypertrophy of the lower extremities (HP:0008968)1.98214333
114Hypophosphatemic rickets (HP:0004912)1.96448587
115Flat capital femoral epiphysis (HP:0003370)1.95871494
116Deformed sella turcica (HP:0002681)1.95731309
117Abnormality of the proximal phalanges of the hand (HP:0009834)1.95519437
118Advanced eruption of teeth (HP:0006288)1.94572500
119Premature skin wrinkling (HP:0100678)1.92767158
120Abnormality of the axillary hair (HP:0100134)1.92163845
121Abnormality of secondary sexual hair (HP:0009888)1.92163845
122Subacute progressive viral hepatitis (HP:0006572)1.91729363
123Hypoplasia of dental enamel (HP:0006297)1.90586528
124Decreased circulating renin level (HP:0003351)1.90132362
125Atrophic scars (HP:0001075)1.89169103
126Hand muscle atrophy (HP:0009130)1.89144636
127Overgrowth (HP:0001548)1.89058074
128Patchy hypopigmentation of hair (HP:0011365)1.88604641
129Atelectasis (HP:0100750)1.88046744
130Trismus (HP:0000211)1.87568048
131Obstructive lung disease (HP:0006536)1.85810036
132Chronic obstructive pulmonary disease (HP:0006510)1.85810036
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.85582569
134Xerostomia (HP:0000217)1.84657030
135Syncope (HP:0001279)1.83308075
136Abnormality of the parathyroid morphology (HP:0011766)1.82985645
137Amelogenesis imperfecta (HP:0000705)1.82305599
138Genetic anticipation (HP:0003743)1.81696305
139Vitreoretinal degeneration (HP:0000655)1.81240436
140Absent speech (HP:0001344)1.81206329
141Broad face (HP:0000283)1.81165738
142Tubulointerstitial abnormality (HP:0001969)1.80567895
143Visual hallucinations (HP:0002367)1.80146259
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79101102
145Megalencephaly (HP:0001355)1.79063414
146Hyperventilation (HP:0002883)1.78711495
147Stomach cancer (HP:0012126)1.78628457
148Bradycardia (HP:0001662)1.78404986
149Hyperthyroidism (HP:0000836)1.78206379
150Pterygium (HP:0001059)1.77174666
151Parakeratosis (HP:0001036)1.77077954
152Myopathic facies (HP:0002058)1.76914747
153Cranial hyperostosis (HP:0004437)1.76676075
154Hyperactive renin-angiotensin system (HP:0000841)1.76358550
155Abnormal hair laboratory examination (HP:0003328)1.75924589
156Abnormality of the nasolacrimal system (HP:0000614)1.75907279
157Humeroradial synostosis (HP:0003041)1.75824372
158Synostosis involving the elbow (HP:0003938)1.75824372
159Urethral obstruction (HP:0000796)1.75350732
160Germ cell neoplasia (HP:0100728)1.75147970
161Abnormality of the septum pellucidum (HP:0007375)1.74769511
162Verrucae (HP:0200043)1.73895449
163Papilloma (HP:0012740)1.73895449
164Retinal dysplasia (HP:0007973)1.73438555
165Abnormality of renin-angiotensin system (HP:0000847)1.73328176
166Nasal speech (HP:0001611)1.72323890
167Neoplasm of the rectum (HP:0100743)1.71793835
168Anonychia (HP:0001798)1.71583285
169Abnormality of the thoracic spine (HP:0100711)1.67816067
170Abnormal vertebral ossification (HP:0100569)1.67778758
171Basal cell carcinoma (HP:0002671)1.67326090
172Absent hair (HP:0002298)1.65231091
173Flattened epiphyses (HP:0003071)1.65154246
174Cone-rod dystrophy (HP:0000548)1.64028276
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63809865
176Selective tooth agenesis (HP:0001592)1.63508957
177Renal cell carcinoma (HP:0005584)1.62153375
17811 pairs of ribs (HP:0000878)1.60593104
179Mildly elevated creatine phosphokinase (HP:0008180)1.60505576
180Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.58465806
181Abnormality of the epiphysis of the femoral head (HP:0010574)1.56583139
182Blepharitis (HP:0000498)1.55769917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.78257761
2CASK5.54099098
3PRKG25.35894136
4BLK4.65698952
5SIK13.77592354
6MAP2K32.83101094
7FGR2.83086805
8NTRK32.76325224
9MAP2K62.73701466
10TRIB32.65858942
11CDK122.49370269
12PIM22.45167217
13EPHA42.29958434
14SMG12.20148163
15INSRR2.15470020
16TNIK2.08821236
17NUAK12.05419377
18NME12.05065012
19EPHB12.02560873
20PNCK1.98771634
21NME21.97244862
22STK391.93051172
23EEF2K1.89544549
24TIE11.73200908
25IRAK31.67374023
26MAP2K41.67115666
27PDGFRA1.65933660
28ERN11.60901418
29FES1.55336673
30MAPK71.54260781
31RIPK11.49747409
32RAF11.47669681
33GRK71.45564796
34BMPR21.43209306
35PLK21.41414517
36FER1.41347382
37MAP4K11.41234935
38PRPF4B1.40291260
39RET1.39047813
40RIPK41.37741518
41MAP2K71.35298431
42GRK11.35247097
43STK241.34501607
44LMTK21.28746574
45MKNK21.26275425
46PKN11.24634148
47ICK1.24209666
48CAMK1G1.22474287
49CDK31.21349834
50OXSR11.21263499
51CAMK2A1.19845178
52STK161.19517369
53ADRBK21.18290113
54PKN21.15098651
55WNK41.12731077
56PRKCE1.11657751
57PIK3CG1.11604861
58PAK61.09580992
59PDGFRB1.09397202
60MUSK1.05677748
61SIK31.05243970
62MAP3K141.05183937
63MAP3K111.03071813
64MAPK131.00522233
65DMPK0.99643823
66OBSCN0.99292985
67TAOK10.97730404
68EPHB20.97566982
69PRKD20.96614627
70ILK0.95528502
71CAMK2B0.95116329
72PTK20.94531861
73MAPKAPK50.93377508
74CLK10.91280920
75NTRK10.87250922
76ZAP700.85550857
77GRK50.85465793
78MARK20.83695918
79ARAF0.81768839
80CAMK2D0.81582256
81SIK20.81389889
82MAP3K70.79175826
83BMX0.79023928
84DDR20.78382938
85DYRK1A0.77886767
86EPHA20.74529939
87MAPK150.74104590
88PAK30.73408742
89MAP2K20.73245857
90PTK60.73143814
91NEK20.71371595
92ADRBK10.70521288
93PTK2B0.69349481
94BCR0.68597052
95TBK10.67873796
96WNK10.67653785
97PIK3CA0.67419387
98LATS20.67228477
99MET0.66414062
100NTRK20.65652824
101KDR0.64567690
102IRAK20.63666608
103CAMK2G0.63001049
104MAP3K40.62531791
105CAMK10.61549206
106TXK0.61145209
107STK38L0.60055579
108MARK10.59256447
109RPS6KB20.58578826
110LATS10.57541780
111PRKG10.57137779
112MAP3K30.56809195
113MST1R0.56477679
114PRKCG0.55849410
115MTOR0.54761508
116PRKACA0.54611351
117PINK10.54443560
118TESK10.53939394
119TNK20.53812394
120MST40.53528416
121CDK50.52830885
122MAP3K130.52661554
123NEK60.52069541
124IKBKB0.51093944
125CDC42BPA0.50745638
126PRKCQ0.50584784
127CDK70.50376499
128ROCK20.50278752
129TTN0.49557139
130JAK30.48826708
131FYN0.48646942
132EIF2AK20.47877513
133TRPM70.47869858
134STK380.46096678
135MAPKAPK30.45653970
136PRKAA10.45312111
137MAP3K50.45197468
138MINK10.44459357
139PAK40.44065580
140MAPK120.43421238
141KSR20.42699296
142MAPK80.41269918
143PBK0.41185300
144PAK20.40271643
145IRAK10.38445792
146SGK10.38433765
147ERBB40.38199093
148NLK0.36022722
149FGFR40.35329882
150HIPK20.34988421
151PRKCA0.34753538
152MAPK100.33860218
153MAP3K100.33856100
154STK110.33631274
155IRAK40.33094626
156ZAK0.33014990
157CAMK1D0.32912428
158ITK0.31715263
159ERBB20.31217729
160CDK90.27711354
161MAPK40.26199519
162PRKD30.24863998
163CHUK0.24800343
164TYRO30.23593308
165CSK0.19590208
166PRKAA20.19482591
167PRKCI0.19213743

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34069108
2Collecting duct acid secretion_Homo sapiens_hsa049662.80678886
3Salivary secretion_Homo sapiens_hsa049702.52975343
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22066392
5Platelet activation_Homo sapiens_hsa046112.19706441
6VEGF signaling pathway_Homo sapiens_hsa043702.18680290
7Morphine addiction_Homo sapiens_hsa050322.17798626
8Taste transduction_Homo sapiens_hsa047422.17563210
9Phototransduction_Homo sapiens_hsa047442.13578914
10Serotonergic synapse_Homo sapiens_hsa047262.04533510
11Oxidative phosphorylation_Homo sapiens_hsa001902.02960743
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01967771
13Rheumatoid arthritis_Homo sapiens_hsa053231.90152167
14Olfactory transduction_Homo sapiens_hsa047401.89740846
15Circadian entrainment_Homo sapiens_hsa047131.84237919
16Glutamatergic synapse_Homo sapiens_hsa047241.77768290
17Histidine metabolism_Homo sapiens_hsa003401.76007068
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75664354
19GABAergic synapse_Homo sapiens_hsa047271.74982392
20Notch signaling pathway_Homo sapiens_hsa043301.72997852
21Synaptic vesicle cycle_Homo sapiens_hsa047211.71405978
22Calcium signaling pathway_Homo sapiens_hsa040201.71138341
23Acute myeloid leukemia_Homo sapiens_hsa052211.64594634
24Phenylalanine metabolism_Homo sapiens_hsa003601.54973332
25Alzheimers disease_Homo sapiens_hsa050101.54888729
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53921391
27Renin secretion_Homo sapiens_hsa049241.52611040
28Vibrio cholerae infection_Homo sapiens_hsa051101.51375158
29Amphetamine addiction_Homo sapiens_hsa050311.49275464
30Long-term depression_Homo sapiens_hsa047301.46648460
31Fatty acid elongation_Homo sapiens_hsa000621.46525917
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42429706
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.39918593
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36495022
35Fatty acid biosynthesis_Homo sapiens_hsa000611.34189814
36Gastric acid secretion_Homo sapiens_hsa049711.32797196
37Chronic myeloid leukemia_Homo sapiens_hsa052201.31481900
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29891764
39Oxytocin signaling pathway_Homo sapiens_hsa049211.28093070
40cAMP signaling pathway_Homo sapiens_hsa040241.27527004
41Insulin secretion_Homo sapiens_hsa049111.26587116
42Ether lipid metabolism_Homo sapiens_hsa005651.26224192
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26001851
44Dopaminergic synapse_Homo sapiens_hsa047281.24546619
45Phagosome_Homo sapiens_hsa041451.23748794
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.21654178
47Axon guidance_Homo sapiens_hsa043601.21465752
48Sphingolipid metabolism_Homo sapiens_hsa006001.19007188
49Glioma_Homo sapiens_hsa052141.18333879
50Cardiac muscle contraction_Homo sapiens_hsa042601.17260827
51Cocaine addiction_Homo sapiens_hsa050301.15730299
52Cholinergic synapse_Homo sapiens_hsa047251.14607956
53Choline metabolism in cancer_Homo sapiens_hsa052311.14041176
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13482502
55Hepatitis C_Homo sapiens_hsa051601.11064470
56AMPK signaling pathway_Homo sapiens_hsa041521.10360248
57Sulfur relay system_Homo sapiens_hsa041221.08165361
58Prolactin signaling pathway_Homo sapiens_hsa049171.07169572
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06511607
60Long-term potentiation_Homo sapiens_hsa047201.06480394
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03383257
62Insulin signaling pathway_Homo sapiens_hsa049101.02780358
63Neurotrophin signaling pathway_Homo sapiens_hsa047221.02609830
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02464901
65Renal cell carcinoma_Homo sapiens_hsa052111.01574018
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99805773
67African trypanosomiasis_Homo sapiens_hsa051430.99800838
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99202222
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.98350255
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98221252
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98077131
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97156935
73Amoebiasis_Homo sapiens_hsa051460.96873034
74T cell receptor signaling pathway_Homo sapiens_hsa046600.96063300
75Parkinsons disease_Homo sapiens_hsa050120.95775199
76Vitamin digestion and absorption_Homo sapiens_hsa049770.95622244
77Dilated cardiomyopathy_Homo sapiens_hsa054140.95587652
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95531582
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93059370
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89693969
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89608258
82Glucagon signaling pathway_Homo sapiens_hsa049220.87743063
83Tyrosine metabolism_Homo sapiens_hsa003500.86797217
84Huntingtons disease_Homo sapiens_hsa050160.84877720
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.83954219
86Pancreatic secretion_Homo sapiens_hsa049720.81050923
87Melanoma_Homo sapiens_hsa052180.80786640
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80040330
89B cell receptor signaling pathway_Homo sapiens_hsa046620.79660459
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79503094
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78163838
92Focal adhesion_Homo sapiens_hsa045100.77325861
93Ras signaling pathway_Homo sapiens_hsa040140.77078338
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76863699
95beta-Alanine metabolism_Homo sapiens_hsa004100.75409884
96ECM-receptor interaction_Homo sapiens_hsa045120.75002238
97Endometrial cancer_Homo sapiens_hsa052130.74879355
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74572861
99Lysosome_Homo sapiens_hsa041420.72560634
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71666831
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.70972818
102Tight junction_Homo sapiens_hsa045300.69022781
103Melanogenesis_Homo sapiens_hsa049160.68313852
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67215435
105Arachidonic acid metabolism_Homo sapiens_hsa005900.67180135
106GnRH signaling pathway_Homo sapiens_hsa049120.66842541
107Bladder cancer_Homo sapiens_hsa052190.62830135
108Rap1 signaling pathway_Homo sapiens_hsa040150.62479280
109Starch and sucrose metabolism_Homo sapiens_hsa005000.62231599
110Pancreatic cancer_Homo sapiens_hsa052120.62157862
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59709020
112Toxoplasmosis_Homo sapiens_hsa051450.58600429
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57711131
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57575190
115Gap junction_Homo sapiens_hsa045400.57415858
116Mineral absorption_Homo sapiens_hsa049780.57242955
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56674727
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55367352
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53362441
120Proteoglycans in cancer_Homo sapiens_hsa052050.53324307
121Non-small cell lung cancer_Homo sapiens_hsa052230.52924559
122Tuberculosis_Homo sapiens_hsa051520.52398759
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.52382399
124Graft-versus-host disease_Homo sapiens_hsa053320.52283766
125Insulin resistance_Homo sapiens_hsa049310.51802856
126MAPK signaling pathway_Homo sapiens_hsa040100.51746425
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51301260
128mTOR signaling pathway_Homo sapiens_hsa041500.51233333
129TNF signaling pathway_Homo sapiens_hsa046680.50370571
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49998217
131mRNA surveillance pathway_Homo sapiens_hsa030150.49098728
132Staphylococcus aureus infection_Homo sapiens_hsa051500.48714354
133MicroRNAs in cancer_Homo sapiens_hsa052060.48612907
134Bile secretion_Homo sapiens_hsa049760.48103058
135ErbB signaling pathway_Homo sapiens_hsa040120.48088199
136Asthma_Homo sapiens_hsa053100.46477977
137Linoleic acid metabolism_Homo sapiens_hsa005910.46217108
138Arginine and proline metabolism_Homo sapiens_hsa003300.46055420
139Autoimmune thyroid disease_Homo sapiens_hsa053200.46024847
140Wnt signaling pathway_Homo sapiens_hsa043100.44888720
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44320535
142Hematopoietic cell lineage_Homo sapiens_hsa046400.44290727
143Estrogen signaling pathway_Homo sapiens_hsa049150.42831127
144Ovarian steroidogenesis_Homo sapiens_hsa049130.42666285
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.42631978
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42333518
147Retinol metabolism_Homo sapiens_hsa008300.41944460
148Malaria_Homo sapiens_hsa051440.41329576
149Circadian rhythm_Homo sapiens_hsa047100.40597267
150Pertussis_Homo sapiens_hsa051330.38592214
151Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37001367
152Other glycan degradation_Homo sapiens_hsa005110.36768629
153Inositol phosphate metabolism_Homo sapiens_hsa005620.36195754
154Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35921805
155Chemokine signaling pathway_Homo sapiens_hsa040620.32804784

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