KLK15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.94651888
2cellular response to exogenous dsRNA (GO:0071360)6.59728606
3hydrogen peroxide biosynthetic process (GO:0050665)6.06150707
4neutrophil activation involved in immune response (GO:0002283)6.01214180
5natural killer cell mediated cytotoxicity (GO:0042267)5.75210929
6natural killer cell mediated immunity (GO:0002228)5.75210929
7respiratory burst (GO:0045730)5.70407379
8regulation of helicase activity (GO:0051095)5.47764530
9cellular response to interferon-beta (GO:0035458)5.43418575
10reactive oxygen species biosynthetic process (GO:1903409)5.35844720
11regulation of RIG-I signaling pathway (GO:0039535)5.23276184
12intracellular pH reduction (GO:0051452)5.18560324
13phagocytosis, recognition (GO:0006910)5.16171271
14positive regulation of monocyte chemotaxis (GO:0090026)4.99014352
15eosinophil chemotaxis (GO:0048245)4.93131661
16cellular response to type I interferon (GO:0071357)4.77020637
17type I interferon signaling pathway (GO:0060337)4.77020637
18superoxide anion generation (GO:0042554)4.71983479
19protein carboxylation (GO:0018214)4.68076847
20peptidyl-glutamic acid carboxylation (GO:0017187)4.68076847
21pH reduction (GO:0045851)4.65755704
22response to type I interferon (GO:0034340)4.64959954
23cellular response to interferon-alpha (GO:0035457)4.58613709
24negative regulation of viral genome replication (GO:0045071)4.47082168
25cellular response to zinc ion (GO:0071294)4.42706832
26regulation of meiosis I (GO:0060631)4.40026259
27positive regulation of vesicle fusion (GO:0031340)4.37908497
28defense response to protozoan (GO:0042832)4.34197159
29eosinophil migration (GO:0072677)4.32211694
30response to interferon-beta (GO:0035456)4.25132602
31regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.24457541
32barbed-end actin filament capping (GO:0051016)4.17474228
33production of molecular mediator involved in inflammatory response (GO:0002532)4.12434674
34positive regulation of endothelial cell apoptotic process (GO:2000353)4.11829584
35serine family amino acid catabolic process (GO:0009071)4.11536596
36regulation of mononuclear cell migration (GO:0071675)4.04462216
37positive regulation of interferon-alpha production (GO:0032727)4.02741493
38immunoglobulin mediated immune response (GO:0016064)3.89486365
39positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.86798118
40positive regulation of DNA recombination (GO:0045911)3.82606708
41regulation of interferon-alpha production (GO:0032647)3.75415719
42sequestering of actin monomers (GO:0042989)3.70949747
43regulation of monocyte chemotaxis (GO:0090025)3.66517262
44response to protozoan (GO:0001562)3.63795612
45neutrophil activation (GO:0042119)3.62300528
46regulation of glutamate secretion (GO:0014048)3.58214978
47regulation of defense response to virus by host (GO:0050691)3.54709401
48positive regulation of interferon-beta production (GO:0032728)3.52863713
49regulation of hypersensitivity (GO:0002883)3.47802386
50granulocyte activation (GO:0036230)3.43300653
51myeloid cell homeostasis (GO:0002262)3.39945375
52positive regulation of natural killer cell differentiation (GO:0032825)3.36042401
53negative regulation of interleukin-8 production (GO:0032717)3.27513684
54hydrogen peroxide metabolic process (GO:0042743)3.24669727
55regulation of cholesterol storage (GO:0010885)3.19793037
56positive regulation of Cdc42 GTPase activity (GO:0043089)3.18139348
57G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.17517544
58regulation of chemokine-mediated signaling pathway (GO:0070099)3.13518187
59positive regulation of protein kinase C signaling (GO:0090037)3.11612756
60superoxide metabolic process (GO:0006801)3.11534361
61positive regulation of antigen processing and presentation (GO:0002579)3.09151688
62adenosine receptor signaling pathway (GO:0001973)3.08119929
63response to interferon-alpha (GO:0035455)3.07566225
64interferon-gamma-mediated signaling pathway (GO:0060333)3.04855407
65leukocyte mediated cytotoxicity (GO:0001909)3.03081709
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00786142
67cellular response to oxygen radical (GO:0071450)2.96239756
68removal of superoxide radicals (GO:0019430)2.96239756
69cellular response to superoxide (GO:0071451)2.96239756
70regulation of T-helper 1 cell differentiation (GO:0045625)2.95178334
71positive regulation of response to biotic stimulus (GO:0002833)2.94971802
72aldehyde catabolic process (GO:0046185)2.93694603
73regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.93206803
74positive regulation of calcium ion import (GO:0090280)2.91652259
75phagosome maturation (GO:0090382)2.88433727
76negative regulation of viral process (GO:0048525)2.87367991
77regulation of intracellular pH (GO:0051453)2.86935579
78heme metabolic process (GO:0042168)2.86853586
79positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.83466844
80macrophage chemotaxis (GO:0048246)2.82794746
81monocyte chemotaxis (GO:0002548)2.82409633
82hydrogen peroxide catabolic process (GO:0042744)2.81488737
83glycosphingolipid catabolic process (GO:0046479)2.80532840
84regulation of interleukin-8 secretion (GO:2000482)2.80122598
85regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.79307615
86negative regulation of B cell proliferation (GO:0030889)2.78422839
87glycine metabolic process (GO:0006544)2.78106081
88heme biosynthetic process (GO:0006783)2.72870525
89negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72234678
90negative regulation of cell killing (GO:0031342)2.72234678
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70958002
92negative regulation of T cell receptor signaling pathway (GO:0050860)2.67772570
93positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.67735880
94cytokine secretion (GO:0050663)2.67690104
95low-density lipoprotein particle clearance (GO:0034383)2.66672059
96membrane raft organization (GO:0031579)2.66156480
97regulation of cellular pH (GO:0030641)2.65101942
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63710162
99negative regulation of protein localization to cell surface (GO:2000009)2.59641855
100regulation of isotype switching to IgG isotypes (GO:0048302)2.57375543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.14490899
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.17202665
3IRF8_21731497_ChIP-ChIP_J774_Mouse7.03995401
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.62965363
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.61537719
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.57892205
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.35781091
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23275194
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93431802
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88380445
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.78233264
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.54254900
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.37531119
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.96739788
15TP63_17297297_ChIP-ChIP_HaCaT_Human1.95823565
16STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92754536
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83269127
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72175455
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66033508
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62057631
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59149119
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55388203
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55388203
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54006766
25CJUN_26792858_Chip-Seq_BT549_Human1.51849731
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45072879
27SOX2_20726797_ChIP-Seq_SW620_Human1.40718064
28VDR_22108803_ChIP-Seq_LS180_Human1.40171165
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38283972
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35403753
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35142101
32MYB_26560356_Chip-Seq_TH2_Human1.34594791
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33166545
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32891105
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31540698
36VDR_24787735_ChIP-Seq_THP-1_Human1.30576986
37VDR_24763502_ChIP-Seq_THP-1_Human1.27388857
38RUNX_20019798_ChIP-Seq_JUKART_Human1.27080216
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26602758
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20956597
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18912311
42PU_27001747_Chip-Seq_BMDM_Mouse1.16303396
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13573850
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.12200450
45GATA3_26560356_Chip-Seq_TH2_Human1.11828983
46SPI1_23547873_ChIP-Seq_NB4_Human1.10313640
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09762068
48EGR1_19032775_ChIP-ChIP_M12_Human1.09446927
49MAF_26560356_Chip-Seq_TH1_Human1.05829349
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04059725
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03459201
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01355805
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00380251
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00273436
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.00206875
56CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98510821
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98036446
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94483539
59RXR_22158963_ChIP-Seq_LIVER_Mouse0.94435408
60PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94006865
61RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92473246
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91114008
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90891917
64FOXO3_23340844_ChIP-Seq_DLD1_Human0.90185341
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88283109
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87562920
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87562920
68GATA3_27048872_Chip-Seq_THYMUS_Human0.87435477
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85944144
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85113714
71SPI1_23127762_ChIP-Seq_K562_Human0.85111831
72SMRT_27268052_Chip-Seq_Bcells_Human0.81698438
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80274980
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74404455
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74261245
76PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72359168
77BCL6_27268052_Chip-Seq_Bcells_Human0.72291561
78ESR1_20079471_ChIP-ChIP_T-47D_Human0.70964011
79RUNX1_22412390_ChIP-Seq_EML_Mouse0.70564274
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69916376
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69358077
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69276235
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.68979016
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68658260
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.67956839
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.65894816
87STAT1_20625510_ChIP-Seq_HELA_Human0.64541811
88MYB_26560356_Chip-Seq_TH1_Human0.64046899
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63678106
90GATA2_21666600_ChIP-Seq_HMVEC_Human0.63605380
91CMYC_18555785_Chip-Seq_ESCs_Mouse0.63094500
92VDR_21846776_ChIP-Seq_THP-1_Human0.62295753
93ESR2_21235772_ChIP-Seq_MCF-7_Human0.61976767
94GATA1_19941826_ChIP-Seq_K562_Human0.61924249
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.61532557
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.60841653
97RXR_22108803_ChIP-Seq_LS180_Human0.60221216
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60202807
99KLF5_25053715_ChIP-Seq_YYC3_Human0.59602046
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58104046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35964241
2MP0002148_abnormal_hypersensitivity_rea3.89483966
3MP0009785_altered_susceptibility_to3.64499030
4MP0004510_myositis3.51257775
5MP0005671_abnormal_response_to3.43064068
6MP0003724_increased_susceptibility_to3.39470862
7MP0003436_decreased_susceptibility_to3.30811859
8MP0005025_abnormal_response_to3.10121272
9MP0003303_peritoneal_inflammation3.07560511
10MP0005000_abnormal_immune_tolerance3.01032336
11MP0002419_abnormal_innate_immunity2.76849000
12MP0003075_altered_response_to2.69692162
13MP0000685_abnormal_immune_system2.56632369
14MP0002877_abnormal_melanocyte_morpholog2.43404498
15MP0002090_abnormal_vision2.36465574
16MP0005387_immune_system_phenotype2.34273815
17MP0001790_abnormal_immune_system2.34273815
18MP0001853_heart_inflammation2.32927875
19MP0002138_abnormal_hepatobiliary_system2.25982743
20MP0002452_abnormal_antigen_presenting2.18646105
21MP0002723_abnormal_immune_serum2.17836566
22MP0006082_CNS_inflammation2.14999494
23MP0005248_abnormal_Harderian_gland2.07725222
24MP0005464_abnormal_platelet_physiology1.95543032
25MP0001819_abnormal_immune_cell1.94401475
26MP0001800_abnormal_humoral_immune1.91297507
27MP0003195_calcinosis1.89391917
28MP0004782_abnormal_surfactant_physiolog1.87987828
29MP0003448_altered_tumor_morphology1.86609394
30MP0002420_abnormal_adaptive_immunity1.84106804
31MP0003191_abnormal_cellular_cholesterol1.82037171
32MP0001845_abnormal_inflammatory_respons1.80943389
33MP0004947_skin_inflammation1.77275068
34MP0000604_amyloidosis1.75692453
35MP0005166_decreased_susceptibility_to1.69731377
36MP0001533_abnormal_skeleton_physiology1.68354659
37MP0005310_abnormal_salivary_gland1.57213301
38MP0002405_respiratory_system_inflammati1.55246698
39MP0005408_hypopigmentation1.50159652
40MP0003186_abnormal_redox_activity1.44100545
41MP0002332_abnormal_exercise_endurance1.37767069
42MP0001542_abnormal_bone_strength1.33364089
43MP0010155_abnormal_intestine_physiology1.30889735
44MP0008469_abnormal_protein_level1.26685742
45MP0000716_abnormal_immune_system1.24670497
46MP0005058_abnormal_lysosome_morphology1.22539791
47MP0010307_abnormal_tumor_latency1.22528689
48MP0002933_joint_inflammation1.21466239
49MP0001663_abnormal_digestive_system1.21133771
50MP0003705_abnormal_hypodermis_morpholog1.19382428
51MP0009840_abnormal_foam_cell1.18271448
52MP0005360_urolithiasis1.17930211
53MP0002398_abnormal_bone_marrow1.14456399
54MP0002166_altered_tumor_susceptibility1.10836854
55MP0003329_amyloid_beta_deposits1.07805891
56MP0002006_tumorigenesis1.06992444
57MP0005187_abnormal_penis_morphology1.05765805
58MP0000569_abnormal_digit_pigmentation1.05251479
59MP0003866_abnormal_defecation1.04966060
60MP0009764_decreased_sensitivity_to1.03880378
61MP0003690_abnormal_glial_cell1.02366660
62MP0004883_abnormal_blood_vessel1.01425363
63MP0010234_abnormal_vibrissa_follicle1.00872311
64MP0002136_abnormal_kidney_physiology1.00821579
65MP0005164_abnormal_response_to0.98517630
66MP0009763_increased_sensitivity_to0.97742241
67MP0005623_abnormal_meninges_morphology0.96512598
68MP0002429_abnormal_blood_cell0.95038208
69MP0005197_abnormal_uvea_morphology0.93790669
70MP0005167_abnormal_blood-brain_barrier0.93636646
71MP0000372_irregular_coat_pigmentation0.92393530
72MP0000343_altered_response_to0.92385757
73MP0001348_abnormal_lacrimal_gland0.90161137
74MP0003453_abnormal_keratinocyte_physiol0.90145182
75MP0003806_abnormal_nucleotide_metabolis0.89355788
76MP0001346_abnormal_lacrimal_gland0.88342229
77MP0000858_altered_metastatic_potential0.83364906
78MP0002998_abnormal_bone_remodeling0.82634513
79MP0005076_abnormal_cell_differentiation0.82294157
80MP0000371_diluted_coat_color0.81763632
81MP0002254_reproductive_system_inflammat0.81540027
82MP0009333_abnormal_splenocyte_physiolog0.80138970
83MP0005381_digestive/alimentary_phenotyp0.78982786
84MP0000689_abnormal_spleen_morphology0.77450658
85MP0005165_increased_susceptibility_to0.77051930
86MP0005023_abnormal_wound_healing0.76928631
87MP0002722_abnormal_immune_system0.76841409
88MP0003136_yellow_coat_color0.76453047
89MP0001915_intracranial_hemorrhage0.76264450
90MP0004130_abnormal_muscle_cell0.75383300
91MP0002139_abnormal_hepatobiliary_system0.75339700
92MP0006054_spinal_hemorrhage0.73416712
93MP0004858_abnormal_nervous_system0.72997905
94MP0001851_eye_inflammation0.71818153
95MP0005390_skeleton_phenotype0.68360111
96MP0008438_abnormal_cutaneous_collagen0.67601060
97MP0003656_abnormal_erythrocyte_physiolo0.67293857
98MP0004019_abnormal_vitamin_homeostasis0.64341184
99MP0003646_muscle_fatigue0.63868606
100MP0004272_abnormal_basement_membrane0.63724745

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)7.02723369
2Eczematoid dermatitis (HP:0000976)6.78157600
3Recurrent abscess formation (HP:0002722)5.83017016
4Poor head control (HP:0002421)5.61895132
5Recurrent bacterial skin infections (HP:0005406)5.59908140
6Elevated erythrocyte sedimentation rate (HP:0003565)5.15918611
7Prolonged partial thromboplastin time (HP:0003645)4.88253007
8Basal ganglia calcification (HP:0002135)4.87295750
9Axonal loss (HP:0003447)4.81344081
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.80961687
11Systemic lupus erythematosus (HP:0002725)4.80609419
12Joint hemorrhage (HP:0005261)4.79798109
13Increased IgM level (HP:0003496)4.21626205
14Gingival bleeding (HP:0000225)4.12835591
15Recurrent skin infections (HP:0001581)3.97715290
16Interstitial pulmonary disease (HP:0006530)3.84086864
17Abnormality of macrophages (HP:0004311)3.75057204
18Chronic obstructive pulmonary disease (HP:0006510)3.71605668
19Obstructive lung disease (HP:0006536)3.71605668
20Myocardial infarction (HP:0001658)3.66737979
21Recurrent fungal infections (HP:0002841)3.59688618
22Chronic mucocutaneous candidiasis (HP:0002728)3.57547273
23Recurrent cutaneous fungal infections (HP:0011370)3.57547273
24Stomatitis (HP:0010280)3.49130705
25Abnormality of liposaccharide metabolism (HP:0010968)3.45541983
26Abnormality of glycosphingolipid metabolism (HP:0004343)3.45541983
27Abnormality of glycolipid metabolism (HP:0010969)3.45541983
28Menorrhagia (HP:0000132)3.41039052
29Prolonged neonatal jaundice (HP:0006579)3.32015528
30Abnormality of the common coagulation pathway (HP:0010990)3.31994373
31Disinhibition (HP:0000734)3.30749002
32Hyperphosphatemia (HP:0002905)3.27166912
33IgA deficiency (HP:0002720)3.27071155
34Mediastinal lymphadenopathy (HP:0100721)3.21646648
35Gingivitis (HP:0000230)3.16667107
36Hemorrhage of the eye (HP:0011885)3.09559292
37Agnosia (HP:0010524)3.04750307
38Vascular calcification (HP:0004934)3.04395529
39Osteomalacia (HP:0002749)3.00899122
40Cheilitis (HP:0100825)2.98115466
41Porencephaly (HP:0002132)2.91929564
42Reduced antithrombin III activity (HP:0001976)2.90654151
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.89947821
44Fatigue (HP:0012378)2.88420034
45Increased cerebral lipofuscin (HP:0011813)2.88020586
463-Methylglutaconic aciduria (HP:0003535)2.85966726
47Recurrent pneumonia (HP:0006532)2.80696982
48Cardiovascular calcification (HP:0011915)2.77268637
49Petechiae (HP:0000967)2.73137481
50Cellulitis (HP:0100658)2.71424551
51Periodontitis (HP:0000704)2.71423312
52IgM deficiency (HP:0002850)2.67545673
53Wide intermamillary distance (HP:0006610)2.67334518
54Abnormality of the intrinsic pathway (HP:0010989)2.62384655
55Vasculitis (HP:0002633)2.56347736
56Bone pain (HP:0002653)2.50356675
57Hepatosplenomegaly (HP:0001433)2.42227706
58Micronodular cirrhosis (HP:0001413)2.38787403
59Fused cervical vertebrae (HP:0002949)2.37287253
60Urticaria (HP:0001025)2.35972097
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31236538
62Apathy (HP:0000741)2.27630253
63Lower limb hyperreflexia (HP:0002395)2.27189835
64Nausea (HP:0002018)2.25358156
65Thyroiditis (HP:0100646)2.21152256
66Diminished motivation (HP:0000745)2.20494715
67Right ventricular cardiomyopathy (HP:0011663)2.17433994
68Recurrent lower respiratory tract infections (HP:0002783)2.13793803
69Epistaxis (HP:0000421)2.12397036
70Pigmentary retinal degeneration (HP:0001146)2.08165416
71Abnormality of proline metabolism (HP:0010907)2.07902366
72Hydroxyprolinuria (HP:0003080)2.07902366
73Abnormality of the basal ganglia (HP:0002134)2.07760730
74Hypergammaglobulinemia (HP:0010702)2.07471874
75Purpura (HP:0000979)2.04878365
76Nephritis (HP:0000123)2.04839335
77Neurofibrillary tangles (HP:0002185)2.04489467
78Progressive visual loss (HP:0000529)2.02217475
79Myopathic facies (HP:0002058)2.01528471
80Severe muscular hypotonia (HP:0006829)2.00867907
81Upper motor neuron abnormality (HP:0002127)2.00241003
82Recurrent bronchitis (HP:0002837)1.99844832
83Gastrointestinal stroma tumor (HP:0100723)1.93890332
84Bone cyst (HP:0012062)1.91638578
85Hematuria (HP:0000790)1.87549744
86Esophageal varix (HP:0002040)1.87543984
87Osteomyelitis (HP:0002754)1.86866674
88Skin ulcer (HP:0200042)1.86864486
89T lymphocytopenia (HP:0005403)1.85895646
90Sepsis (HP:0100806)1.85870183
91Conjunctival telangiectasia (HP:0000524)1.85687509
92Autoimmune thrombocytopenia (HP:0001973)1.84095174
93Tetraparesis (HP:0002273)1.81274415
94Cortical dysplasia (HP:0002539)1.80106874
95Cleft eyelid (HP:0000625)1.79659326
96Arthralgia (HP:0002829)1.79301676
97Abnormality of T cell number (HP:0011839)1.78939530
98Cerebral hemorrhage (HP:0001342)1.77778992
99Cutaneous photosensitivity (HP:0000992)1.75938306
100IgG deficiency (HP:0004315)1.74093625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK9.52015718
2ERBB35.59928206
3TRPM73.94639046
4MAP3K143.40219222
5RIPK43.16203716
6TBK12.96573806
7MST42.90967314
8BMPR22.75440782
9ABL22.36214059
10NEK91.98583324
11IKBKB1.96329026
12TAOK31.67168743
13EPHA21.56839088
14LIMK11.54712855
15TESK11.54404393
16BLK1.50660585
17IRAK41.46204847
18STK41.41913708
19TXK1.39942728
20MST1R1.17238364
21IKBKE1.16198193
22CHUK1.14476414
23MAP4K11.11242435
24MAP3K131.09406557
25SYK1.05814489
26HCK1.03297537
27EIF2AK11.01525411
28LATS11.01506904
29JAK30.94264691
30BMX0.92825967
31PIM20.91873043
32KSR20.88735750
33TYK20.88527645
34LCK0.84400867
35MAP3K20.81613900
36EPHB10.80071447
37MET0.78081000
38ABL10.76543132
39MOS0.74237587
40CSK0.73373939
41JAK10.72955480
42MATK0.72457146
43ERBB40.71789647
44ACVR1B0.70071911
45TAOK10.69505067
46ZAK0.68007589
47RPS6KA40.64655253
48JAK20.64538741
49STK100.64141514
50EGFR0.59682173
51LYN0.57734425
52FGR0.57588880
53MAP3K10.56896760
54TTN0.54460054
55NEK60.54284907
56PIK3CA0.52789741
57ICK0.50601470
58MAPK120.50356898
59FES0.48462711
60TNIK0.47954574
61PRKCD0.47716185
62DDR20.43112596
63PRKCQ0.41060734
64PIM10.38899739
65NUAK10.37873130
66IRAK30.35828865
67SRC0.34828782
68CDC42BPA0.34307938
69MAP2K10.30815462
70CSF1R0.30667115
71BMPR1B0.29411565
72DAPK20.29349723
73RET0.29027277
74KIT0.28145035
75DAPK30.27809890
76PTK60.27627450
77PRKCH0.25546037
78BTK0.24664156
79YES10.22381591
80PTK20.21938381
81FYN0.21714954
82STK30.21367452
83PAK40.20607611
84FRK0.20451708
85DMPK0.19237238
86ROCK20.19229081
87IGF1R0.17748706
88NTRK30.17133633
89NME10.16412523
90GRK70.15583250
91LATS20.14906360
92PRKACG0.14159319
93LRRK20.13702103
94ERN10.13551237
95PRKG10.13513869
96PKN10.13252892
97MAP2K20.13214259
98SGK10.12927725
99PDK20.11887813
100TGFBR10.11564881

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.46619271
2Sulfur metabolism_Homo sapiens_hsa009203.18272206
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.08120114
4Leishmaniasis_Homo sapiens_hsa051403.04229491
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.79841859
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.65143666
7Viral myocarditis_Homo sapiens_hsa054162.59597102
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46113038
9Asthma_Homo sapiens_hsa053102.42165550
10Phagosome_Homo sapiens_hsa041452.37083773
11Staphylococcus aureus infection_Homo sapiens_hsa051502.36074484
12Malaria_Homo sapiens_hsa051442.19963608
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.05243707
14Tuberculosis_Homo sapiens_hsa051521.97706178
15Complement and coagulation cascades_Homo sapiens_hsa046101.95907079
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94729834
17Autoimmune thyroid disease_Homo sapiens_hsa053201.93022216
18Osteoclast differentiation_Homo sapiens_hsa043801.90706022
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89649176
20Rheumatoid arthritis_Homo sapiens_hsa053231.88075633
21Lysosome_Homo sapiens_hsa041421.87048062
22Pertussis_Homo sapiens_hsa051331.83092329
23Toxoplasmosis_Homo sapiens_hsa051451.53080546
24Primary immunodeficiency_Homo sapiens_hsa053401.52626072
25Vibrio cholerae infection_Homo sapiens_hsa051101.51535075
26Graft-versus-host disease_Homo sapiens_hsa053321.37461630
27Legionellosis_Homo sapiens_hsa051341.36179119
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32400150
29Caffeine metabolism_Homo sapiens_hsa002321.31920275
30Salmonella infection_Homo sapiens_hsa051321.30237846
31Chemokine signaling pathway_Homo sapiens_hsa040621.29263433
32Collecting duct acid secretion_Homo sapiens_hsa049661.27003190
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.16825785
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14788543
35Phenylalanine metabolism_Homo sapiens_hsa003601.11437659
36Influenza A_Homo sapiens_hsa051641.07102505
37B cell receptor signaling pathway_Homo sapiens_hsa046621.03991681
38Type I diabetes mellitus_Homo sapiens_hsa049401.02239249
39Herpes simplex infection_Homo sapiens_hsa051681.01584500
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01196816
41Apoptosis_Homo sapiens_hsa042100.97664602
42Amoebiasis_Homo sapiens_hsa051460.96658649
43Steroid biosynthesis_Homo sapiens_hsa001000.94590647
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94519447
45Measles_Homo sapiens_hsa051620.93320039
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90809914
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.88939228
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84104892
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82418026
50Shigellosis_Homo sapiens_hsa051310.81314234
51Mineral absorption_Homo sapiens_hsa049780.80124720
52Proteasome_Homo sapiens_hsa030500.76575604
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76418792
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72588566
55African trypanosomiasis_Homo sapiens_hsa051430.72486081
56Antigen processing and presentation_Homo sapiens_hsa046120.70949889
57Synaptic vesicle cycle_Homo sapiens_hsa047210.70195975
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69774562
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68129723
60Platelet activation_Homo sapiens_hsa046110.64936330
61Adherens junction_Homo sapiens_hsa045200.64029915
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63519149
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63206859
64Hepatitis C_Homo sapiens_hsa051600.62712088
65Ether lipid metabolism_Homo sapiens_hsa005650.61768438
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61270756
67TNF signaling pathway_Homo sapiens_hsa046680.54915002
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53200927
69Hematopoietic cell lineage_Homo sapiens_hsa046400.53071085
70Arginine biosynthesis_Homo sapiens_hsa002200.52205355
71Dorso-ventral axis formation_Homo sapiens_hsa043200.51675997
72Parkinsons disease_Homo sapiens_hsa050120.47424738
73Histidine metabolism_Homo sapiens_hsa003400.46326984
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45463450
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.39429256
76Peroxisome_Homo sapiens_hsa041460.35294773
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.34148238
78Thyroid cancer_Homo sapiens_hsa052160.34078946
79Oxidative phosphorylation_Homo sapiens_hsa001900.33917215
80Glycerolipid metabolism_Homo sapiens_hsa005610.31520951
81Proteoglycans in cancer_Homo sapiens_hsa052050.31222773
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30682635
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30098093
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27049566
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25721653
86Epstein-Barr virus infection_Homo sapiens_hsa051690.24800474
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24729456
88Hepatitis B_Homo sapiens_hsa051610.23620638
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23620420
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23550732
91Systemic lupus erythematosus_Homo sapiens_hsa053220.23454880
92HIF-1 signaling pathway_Homo sapiens_hsa040660.22251297
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21056096
94PPAR signaling pathway_Homo sapiens_hsa033200.19243420
95Endocytosis_Homo sapiens_hsa041440.19177452
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18439821
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17099428
98Vitamin digestion and absorption_Homo sapiens_hsa049770.16419128
99GABAergic synapse_Homo sapiens_hsa047270.16326221
100Long-term potentiation_Homo sapiens_hsa047200.15781834

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