KLK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1biotin metabolic process (GO:0006768)8.47000932
2positive regulation of macrophage cytokine production (GO:0060907)8.23335014
3artery development (GO:0060840)7.95683665
4opsonization (GO:0008228)7.90626333
5peptidyl-tyrosine autophosphorylation (GO:0038083)7.22331408
6prostate gland epithelium morphogenesis (GO:0060740)6.85613256
7regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)6.79790037
8positive regulation of transcription from RNA polymerase III promoter (GO:0045945)6.66463358
9regulation of receptor binding (GO:1900120)6.50598584
10endothelial cell chemotaxis (GO:0035767)6.30739845
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.26693907
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.16246980
13positive regulation of steroid hormone secretion (GO:2000833)6.15888650
14epithelial cell maturation (GO:0002070)6.14934467
15carnitine shuttle (GO:0006853)5.88561544
16positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)5.78277974
17acetyl-CoA metabolic process (GO:0006084)5.71164874
18mitotic cell cycle arrest (GO:0071850)5.59386358
19fatty-acyl-CoA biosynthetic process (GO:0046949)5.56826284
20positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610815.52964346
21iron ion import (GO:0097286)5.46236672
22regulation of macrophage cytokine production (GO:0010935)5.21285541
23protein autoprocessing (GO:0016540)5.13240582
24pharyngeal system development (GO:0060037)5.07673142
25lung epithelial cell differentiation (GO:0060487)5.05253399
26response to testosterone (GO:0033574)5.04930789
27regulation of protein polyubiquitination (GO:1902914)4.97830526
28thioester biosynthetic process (GO:0035384)4.97748022
29acyl-CoA biosynthetic process (GO:0071616)4.97748022
30lung cell differentiation (GO:0060479)4.89573152
31positive regulation of cellular amine metabolic process (GO:0033240)4.85839940
32glucocorticoid receptor signaling pathway (GO:0042921)4.72773520
33fatty acid transmembrane transport (GO:1902001)4.70426500
34intestinal epithelial cell development (GO:0060576)4.67325351
35carnitine transmembrane transport (GO:1902603)4.66585118
36adenosine metabolic process (GO:0046085)4.63930425
37coenzyme A biosynthetic process (GO:0015937)4.63239263
38epithelial cell differentiation involved in prostate gland development (GO:0060742)4.37406127
39negative regulation of DNA repair (GO:0045738)4.35328723
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.30363013
41regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.30243540
42carnitine transport (GO:0015879)4.20918484
43amino-acid betaine transport (GO:0015838)4.20918484
44Golgi to endosome transport (GO:0006895)4.20518651
45regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.13770548
46mitochondrion degradation (GO:0000422)4.09776179
47regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.05516543
48positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)4.05229710
49myeloid leukocyte mediated immunity (GO:0002444)3.88740696
50establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.81641075
51regulation of steroid hormone secretion (GO:2000831)3.81514421
52import into cell (GO:0098657)3.81144937
53androgen receptor signaling pathway (GO:0030521)3.80812882
54very-low-density lipoprotein particle assembly (GO:0034379)3.78418728
55piRNA metabolic process (GO:0034587)3.78216028
56apical protein localization (GO:0045176)3.75702115
57purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.70660670
58ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.70660670
59nucleoside bisphosphate biosynthetic process (GO:0033866)3.70660670
60glandular epithelial cell differentiation (GO:0002067)3.65697431
61corticosteroid receptor signaling pathway (GO:0031958)3.63962014
62coenzyme A metabolic process (GO:0015936)3.63883654
63cytoskeletal anchoring at plasma membrane (GO:0007016)3.59902748
64regulation of transcription from RNA polymerase III promoter (GO:0006359)3.53473261
65fatty-acyl-CoA metabolic process (GO:0035337)3.52885321
66pantothenate metabolic process (GO:0015939)3.49320564
67regulation of ARF protein signal transduction (GO:0032012)3.43475339
68cell-cell junction maintenance (GO:0045217)3.42595577
69detection of temperature stimulus (GO:0016048)3.39023871
70positive regulation by host of viral transcription (GO:0043923)3.38758250
71quaternary ammonium group transport (GO:0015697)3.34391610
72lung secretory cell differentiation (GO:0061140)3.33631214
73negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.24841728
74embryonic retina morphogenesis in camera-type eye (GO:0060059)3.20451187
75DNA methylation involved in gamete generation (GO:0043046)3.17920297
76regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.16496834
77dorsal/ventral neural tube patterning (GO:0021904)3.14961529
78negative regulation of cell fate commitment (GO:0010454)3.06793353
79mitochondrion localization (GO:0051646)3.05583811
80synaptic vesicle docking involved in exocytosis (GO:0016081)3.05133427
81regulation of fatty acid beta-oxidation (GO:0031998)3.00999112
82regulation of actin nucleation (GO:0051125)2.99915354
83histone H3-K4 trimethylation (GO:0080182)2.97382162
84COPII vesicle coating (GO:0048208)2.94081486
85lung lobe morphogenesis (GO:0060463)2.93463356
86ruffle organization (GO:0031529)2.92155770
87myelin maintenance (GO:0043217)2.91507504
88NLS-bearing protein import into nucleus (GO:0006607)2.89179381
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87002140
90epithelial tube branching involved in lung morphogenesis (GO:0060441)2.86917509
91sex differentiation (GO:0007548)2.85608611
92endoplasmic reticulum organization (GO:0007029)2.85587382
93asymmetric protein localization (GO:0008105)2.85353613
94histone H3-K4 methylation (GO:0051568)2.83221982
95regulation of sensory perception of pain (GO:0051930)2.83014659
96regulation of sensory perception (GO:0051931)2.83014659
97intracellular lipid transport (GO:0032365)2.73264361
98peptidyl-threonine phosphorylation (GO:0018107)2.73252176
99regulation of viral entry into host cell (GO:0046596)2.70833772
100branching involved in prostate gland morphogenesis (GO:0060442)10.5380771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PIAS1_25552417_ChIP-Seq_VCAP_Human5.68160517
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.16596004
3AR_21909140_ChIP-Seq_LNCAP_Human5.12035968
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.94697942
5FOXA1_25552417_ChIP-Seq_VCAP_Human3.53900200
6* AR_21915096_ChIP-Seq_LNCaP-1F5_Human3.39613081
7EZH2_22144423_ChIP-Seq_EOC_Human3.20691351
8* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.07843128
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.00136732
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.90483291
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.81506690
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.76930233
13DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.62685146
14CHD1_26751641_Chip-Seq_LNCaP_Human2.61877657
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61293565
16AR_21572438_ChIP-Seq_LNCaP_Human2.46284366
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.35759375
18* RACK7_27058665_Chip-Seq_MCF-7_Human2.01996063
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93531118
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93330009
21CREB1_26743006_Chip-Seq_LNCaP_Human1.91231117
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88717545
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88717545
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88717545
25TCF7_22412390_ChIP-Seq_EML_Mouse1.82345353
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.79991365
27DROSHA_22980978_ChIP-Seq_HELA_Human1.79090468
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.76177005
29KDM5A_27292631_Chip-Seq_BREAST_Human1.73889102
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73532666
31ZNF263_19887448_ChIP-Seq_K562_Human1.71882254
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71120897
33LXR_22292898_ChIP-Seq_THP-1_Human1.70132827
34* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.66540515
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66050939
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55255077
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53429032
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.50198449
39VDR_21846776_ChIP-Seq_THP-1_Human1.49458574
40* ERG_20517297_ChIP-Seq_VCAP_Human1.49067002
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.48660052
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46694407
43MYC_22102868_ChIP-Seq_BL_Human1.45794006
44SMC4_20622854_ChIP-Seq_HELA_Human1.43126713
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.42194172
46OCT1_27270436_Chip-Seq_PROSTATE_Human1.38318650
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36555031
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27838848
49KDM2B_26808549_Chip-Seq_K562_Human1.27090717
50SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26632777
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26489870
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23733207
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23378890
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20891694
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18933403
56ELF5_23300383_ChIP-Seq_T47D_Human1.18522997
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.18207884
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16202481
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16106747
60IGF1R_20145208_ChIP-Seq_DFB_Human1.13998740
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.13951853
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13655346
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.11671438
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.11520910
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10033054
66AR_25329375_ChIP-Seq_VCAP_Human1.09988918
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.09048209
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07836865
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07369096
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06413127
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.04985979
72GATA6_25053715_ChIP-Seq_YYC3_Human1.04617505
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04591179
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03283619
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.01642373
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97599744
77ESR1_20079471_ChIP-ChIP_T-47D_Human0.96109280
78CDX2_20551321_ChIP-Seq_CACO-2_Human0.95930690
79KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95797965
80HTT_18923047_ChIP-ChIP_STHdh_Human0.93921192
81NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92841565
82VDR_24763502_ChIP-Seq_THP-1_Human0.91916685
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91488569
84CIITA_25753668_ChIP-Seq_RAJI_Human0.90597554
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89953315
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89917480
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.89829852
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89723717
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.88464725
90P68_20966046_ChIP-Seq_HELA_Human0.87977425
91ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87459379
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.87433904
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.85627834
94CLOCK_20551151_ChIP-Seq_293T_Human0.85323161
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.83314533
96KDM2B_26808549_Chip-Seq_DND41_Human0.83030184
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80946569
98AHR_22903824_ChIP-Seq_MCF-7_Human0.79299274
99GATA4_25053715_ChIP-Seq_YYC3_Human0.78959991
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78949169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia6.24318356
2MP0002166_altered_tumor_susceptibility5.54124343
3MP0000537_abnormal_urethra_morphology5.49905978
4MP0004145_abnormal_muscle_electrophysio4.97618858
5MP0005645_abnormal_hypothalamus_physiol4.78825745
6MP0005310_abnormal_salivary_gland4.37585160
7MP0002006_tumorigenesis4.14172366
8MP0003315_abnormal_perineum_morphology3.88009779
9MP0002822_catalepsy3.57652586
10MP0002234_abnormal_pharynx_morphology3.39577525
11MP0008961_abnormal_basal_metabolism3.26032978
12MP0004858_abnormal_nervous_system3.12157559
13MP0004185_abnormal_adipocyte_glucose2.98338077
14MP0003283_abnormal_digestive_organ2.52215914
15MP0000538_abnormal_urinary_bladder2.41364464
16MP0001873_stomach_inflammation2.35856203
17MP0005647_abnormal_sex_gland2.32122373
18MP0010234_abnormal_vibrissa_follicle2.22690948
19MP0002735_abnormal_chemical_nociception2.16760700
20MP0005167_abnormal_blood-brain_barrier2.02488244
21MP0005670_abnormal_white_adipose1.87423616
22MP0005076_abnormal_cell_differentiation1.74915015
23MP0005367_renal/urinary_system_phenotyp1.72690407
24MP0000516_abnormal_urinary_system1.72690407
25MP0005451_abnormal_body_composition1.71925067
26MP0005666_abnormal_adipose_tissue1.71583038
27MP0002909_abnormal_adrenal_gland1.68772203
28MP0002736_abnormal_nociception_after1.68227444
29MP0004036_abnormal_muscle_relaxation1.55302219
30MP0005220_abnormal_exocrine_pancreas1.49004926
31MP0003879_abnormal_hair_cell1.38667148
32MP0000613_abnormal_salivary_gland1.38413987
33MP0003011_delayed_dark_adaptation1.14142953
34MP0005646_abnormal_pituitary_gland1.12245938
35MP0001919_abnormal_reproductive_system1.09532804
36MP0005187_abnormal_penis_morphology1.07211281
37MP0000534_abnormal_ureter_morphology1.03430989
38MP0002108_abnormal_muscle_morphology1.02664483
39MP0001765_abnormal_ion_homeostasis0.97953294
40MP0005448_abnormal_energy_balance0.96742044
41MP0004233_abnormal_muscle_weight0.95503344
42MP0001501_abnormal_sleep_pattern0.95372611
43MP0002693_abnormal_pancreas_physiology0.94634148
44MP0005375_adipose_tissue_phenotype0.93497795
45MP0001968_abnormal_touch/_nociception0.93011381
46MP0001348_abnormal_lacrimal_gland0.92921411
47MP0006276_abnormal_autonomic_nervous0.92141546
48MP0001664_abnormal_digestion0.90313346
49MP0000678_abnormal_parathyroid_gland0.88497250
50MP0001756_abnormal_urination0.88205492
51MP0003705_abnormal_hypodermis_morpholog0.86013887
52MP0000631_abnormal_neuroendocrine_gland0.84545690
53MP0002653_abnormal_ependyma_morphology0.83517998
54MP0002557_abnormal_social/conspecific_i0.81620796
55MP0001764_abnormal_homeostasis0.79099907
56MP0002277_abnormal_respiratory_mucosa0.77971818
57MP0005623_abnormal_meninges_morphology0.76514897
58MP0001944_abnormal_pancreas_morphology0.74429558
59MP0003942_abnormal_urinary_system0.73297337
60MP0002078_abnormal_glucose_homeostasis0.71590273
61MP0000733_abnormal_muscle_development0.66715841
62MP0000462_abnormal_digestive_system0.66619986
63MP0002876_abnormal_thyroid_physiology0.66560272
64MP0002249_abnormal_larynx_morphology0.65203556
65MP0010386_abnormal_urinary_bladder0.64400037
66MP0003045_fibrosis0.62487088
67MP0004043_abnormal_pH_regulation0.62379023
68MP0002089_abnormal_postnatal_growth/wei0.61238725
69MP0003953_abnormal_hormone_level0.59049240
70MP0002090_abnormal_vision0.57803438
71MP0000230_abnormal_systemic_arterial0.55674804
72MP0000432_abnormal_head_morphology0.55644372
73MP0002111_abnormal_tail_morphology0.55198993
74MP0002733_abnormal_thermal_nociception0.54086287
75MP0000627_abnormal_mammary_gland0.51256321
76MP0001730_embryonic_growth_arrest0.50177226
77MP0001485_abnormal_pinna_reflex0.50153653
78MP0003984_embryonic_growth_retardation0.49535637
79MP0003633_abnormal_nervous_system0.48690674
80MP0000747_muscle_weakness0.48563024
81MP0002088_abnormal_embryonic_growth/wei0.47888548
82MP0000477_abnormal_intestine_morphology0.47808046
83MP0000920_abnormal_myelination0.46173414
84MP0003646_muscle_fatigue0.45729280
85MP0004264_abnormal_extraembryonic_tissu0.45573559
86MP0000955_abnormal_spinal_cord0.45492328
87MP0005636_abnormal_mineral_homeostasis0.44685931
88MP0005085_abnormal_gallbladder_physiolo0.43784474
89MP0001661_extended_life_span0.43616312
90MP0002734_abnormal_mechanical_nocicepti0.42608654
91MP0001145_abnormal_male_reproductive0.42092649
92MP0001970_abnormal_pain_threshold0.40828589
93MP0000566_synostosis0.40162307
94MP0002160_abnormal_reproductive_system0.39110760
95MP0002118_abnormal_lipid_homeostasis0.38909176
96MP0002069_abnormal_eating/drinking_beha0.37447436
97MP0000470_abnormal_stomach_morphology0.37403168
98MP0001731_abnormal_postnatal_growth0.36733941
99MP0002115_abnormal_skeleton_extremities0.35702485
100MP0009053_abnormal_anal_canal0.35285767

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.72426489
2Abnormality of the 1st metacarpal (HP:0010009)5.71929485
3Abnormality of secondary sexual hair (HP:0009888)5.58672846
4Abnormality of the axillary hair (HP:0100134)5.58672846
5Short 1st metacarpal (HP:0010034)5.45544013
6Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.45544013
7Calf muscle hypertrophy (HP:0008981)5.36888209
8Flat acetabular roof (HP:0003180)5.16853018
9Prostate neoplasm (HP:0100787)5.10465646
10Gonadotropin excess (HP:0000837)5.08840229
11Broad face (HP:0000283)4.73904924
12Abnormality of the distal phalanx of the thumb (HP:0009617)4.72244933
13Abnormal tarsal ossification (HP:0008369)4.70525466
14Muscle hypertrophy of the lower extremities (HP:0008968)4.69998622
15Short phalanx of the thumb (HP:0009660)4.51025306
16Abnormality of the phalanges of the hallux (HP:0010057)4.45740648
17Myokymia (HP:0002411)4.30622305
18Abnormality of carpal bone ossification (HP:0006257)4.14934787
19Abnormality of the proximal phalanges of the hand (HP:0009834)3.91311026
20Septate vagina (HP:0001153)3.87515745
21Abnormal foot bone ossification (HP:0010675)3.50710053
22Abnormal hand bone ossification (HP:0010660)3.48583402
23Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.43586625
24Amelogenesis imperfecta (HP:0000705)3.43054797
25Abnormal ossification of hand bones (HP:0005921)3.41435447
26Abnormality of the parathyroid morphology (HP:0011766)3.27110860
27Bronchomalacia (HP:0002780)3.26472020
28Abnormality of the distal phalanges of the toes (HP:0010182)3.24198380
29Azoospermia (HP:0000027)3.21541501
30Partial duplication of thumb phalanx (HP:0009944)3.14639541
31Sparse lateral eyebrow (HP:0005338)3.13134698
32Flattened epiphyses (HP:0003071)3.12193847
33Bifid scrotum (HP:0000048)3.05644793
34Anal stenosis (HP:0002025)3.00896742
3511 pairs of ribs (HP:0000878)2.99588071
36Abnormality of the fingertips (HP:0001211)2.97066326
37Broad metatarsal (HP:0001783)2.90356720
38Testicular neoplasm (HP:0010788)2.77476511
39Impaired smooth pursuit (HP:0007772)2.75674426
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.74756936
41Partial duplication of the phalanx of hand (HP:0009999)2.64928139
42Aplasia/hypoplasia of the femur (HP:0005613)2.60605465
43Short nail (HP:0001799)2.58111634
44Microretrognathia (HP:0000308)2.57652515
45Gaze-evoked nystagmus (HP:0000640)2.56463635
46Abnormality of the nasal septum (HP:0000419)2.55775541
47Cervical subluxation (HP:0003308)2.55692673
48Dysdiadochokinesis (HP:0002075)2.50459668
49Fibular aplasia (HP:0002990)2.44733066
50Aplastic anemia (HP:0001915)2.41231821
51Genetic anticipation (HP:0003743)2.40450813
52Dysmetric saccades (HP:0000641)2.40390764
53Abnormality of the prostate (HP:0008775)2.37919960
54Shallow orbits (HP:0000586)2.32580182
55Growth hormone excess (HP:0000845)2.31990531
56Axonal loss (HP:0003447)2.31754562
57Hyperpituitarism (HP:0010514)2.28989307
58Ureteral stenosis (HP:0000071)2.22648857
59Tracheomalacia (HP:0002779)2.20198179
60Laryngomalacia (HP:0001601)2.20066959
61Urethral obstruction (HP:0000796)2.17330034
62Aortic aneurysm (HP:0004942)2.17089838
63Abnormal spermatogenesis (HP:0008669)2.16655275
64Neonatal hypoglycemia (HP:0001998)2.14361315
65Obstructive sleep apnea (HP:0002870)2.13239587
66Bulbar palsy (HP:0001283)2.11181806
67Ureteral obstruction (HP:0006000)2.11074758
68Long eyelashes (HP:0000527)2.08185698
69Absent hair (HP:0002298)2.06778919
70Congenital glaucoma (HP:0001087)2.06554684
71Neoplasm of the adrenal cortex (HP:0100641)2.03963889
72Abnormality of the calf musculature (HP:0001430)2.01813987
73Abnormality of ocular smooth pursuit (HP:0000617)2.01466795
74Intention tremor (HP:0002080)2.01158472
75Severe short stature (HP:0003510)1.97962460
76Intrahepatic cholestasis (HP:0001406)1.94594635
77Overgrowth (HP:0001548)1.92946158
78Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.92389491
79Advanced eruption of teeth (HP:0006288)1.92098692
80Segmental peripheral demyelination/remyelination (HP:0003481)1.91917798
81Short femoral neck (HP:0100864)1.90569927
82Short humerus (HP:0005792)1.88588396
83Abnormality of the Achilles tendon (HP:0005109)1.88258256
84Germ cell neoplasia (HP:0100728)1.87694433
85Persistence of primary teeth (HP:0006335)1.81713907
86Narrow palate (HP:0000189)1.80608584
87Tented upper lip vermilion (HP:0010804)1.80479676
88Limb ataxia (HP:0002070)1.79813031
89Neoplasm of the heart (HP:0100544)1.78617793
90Lower limb hyperreflexia (HP:0002395)1.77102306
91Abnormality of homocysteine metabolism (HP:0010919)1.76876320
92Homocystinuria (HP:0002156)1.76876320
93Radial bowing (HP:0002986)1.76846067
94Lip pit (HP:0100267)1.74666237
95Spinal cord compression (HP:0002176)1.73723526
96Abnormality of the fibula (HP:0002991)1.72029756
97Abnormality of male internal genitalia (HP:0000022)1.71028599
98Macroorchidism (HP:0000053)1.68301287
99Midface retrusion (HP:0011800)1.67969544
100Abnormal vertebral ossification (HP:0100569)1.67440901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D8.65872931
2CAMK1G6.71931393
3TAOK16.15757069
4TNK24.97419919
5AKT33.04117306
6EEF2K2.82252659
7TRIB32.76725006
8PIM22.74774303
9PRKD22.68529558
10MARK22.52031318
11FER2.27111072
12PRKCI1.72187867
13ARAF1.64432258
14ERN11.62273528
15CDK121.51979232
16SMG11.51555867
17RIPK41.48569589
18IRAK31.47194678
19PRKD31.34199794
20IRAK21.22700133
21MTOR1.16183284
22CAMK11.12805018
23TESK21.11307397
24RAF11.05693206
25PAK20.97019014
26SGK2230.91042967
27SGK4940.91042967
28PRKAA20.88766468
29MINK10.81403661
30PRKAA10.79941272
31BRAF0.77797138
32SIK10.75469679
33MAP3K110.69201548
34PKN20.66180069
35ICK0.65921355
36MYLK0.60530821
37DAPK20.59308236
38STK110.57184395
39WNK10.53737413
40ACVR1B0.51569918
41CDC42BPA0.50631772
42CDK70.47626643
43MAP4K10.45991234
44PRKCZ0.45433527
45GSK3A0.45414069
46PRKD10.40299306
47WNK40.38805388
48SGK30.36426716
49SCYL20.34960979
50SGK20.33663787
51BRD40.32917065
52CAMKK10.31724645
53MAPK80.28902512
54SGK10.28793857
55AURKA0.28781696
56IRAK10.27005195
57IRAK40.26994190
58RPS6KA40.26701950
59TESK10.26259825
60CAMK40.25957236
61YES10.25532198
62GSK3B0.25022151
63CHUK0.24637122
64MAPK100.24392766
65PDPK10.24047408
66STK390.23848091
67CAMKK20.23406387
68MAP3K70.21972387
69AKT10.20268381
70ILK0.18446700
71DDR20.18310393
72EPHA20.18242661
73PAK30.18234182
74BCR0.17600354
75RPS6KA20.17328766
76LATS10.15851036
77MAPKAPK30.14679413
78AURKB0.14116790
79PDK10.13986463
80CCNB10.13322404
81MAPK140.12178191
82CDK10.11718698
83DMPK0.11652969
84CDK90.11095472
85RPS6KA30.10943362
86STK380.10797165
87CSNK2A20.09900979
88MAPK10.09375512
89MAPK90.08987373
90PRKDC0.08681163
91RPS6KA50.07557879
92PIM10.07305369
93CDK20.07124910
94BCKDK0.06489957
95MAP2K20.06192742
96CSNK1A10.05922937
97NLK0.05835011
98CSNK1E0.05538985
99AKT20.05102380
100PRKG20.05009592

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid metabolism_Homo sapiens_hsa012123.01004397
2Prostate cancer_Homo sapiens_hsa052152.74627412
3Steroid biosynthesis_Homo sapiens_hsa001002.61780662
4Lysine degradation_Homo sapiens_hsa003102.12709611
5Fatty acid biosynthesis_Homo sapiens_hsa0006110.8194445
6Notch signaling pathway_Homo sapiens_hsa043301.79833982
7Propanoate metabolism_Homo sapiens_hsa006401.71023515
8Thyroid hormone synthesis_Homo sapiens_hsa049181.69293289
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.56134444
10AMPK signaling pathway_Homo sapiens_hsa041521.52978404
11Pyruvate metabolism_Homo sapiens_hsa006201.52283388
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50935172
13Vascular smooth muscle contraction_Homo sapiens_hsa042701.49431654
14Glucagon signaling pathway_Homo sapiens_hsa049221.47984429
15Renin secretion_Homo sapiens_hsa049241.35854259
16Cholinergic synapse_Homo sapiens_hsa047251.25608314
17Transcriptional misregulation in cancer_Homo sapiens_hsa052021.23666815
18Type II diabetes mellitus_Homo sapiens_hsa049301.21592738
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21147250
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.17701452
21Insulin signaling pathway_Homo sapiens_hsa049101.15945134
22Insulin secretion_Homo sapiens_hsa049111.10370068
23Long-term depression_Homo sapiens_hsa047301.08732526
24Vitamin digestion and absorption_Homo sapiens_hsa049771.06903706
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06232145
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.05422822
27Estrogen signaling pathway_Homo sapiens_hsa049151.01536047
28Serotonergic synapse_Homo sapiens_hsa047261.00433351
29ABC transporters_Homo sapiens_hsa020100.95895621
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94971656
31Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94725332
32Tight junction_Homo sapiens_hsa045300.94717938
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93309595
34Salivary secretion_Homo sapiens_hsa049700.92979606
35Insulin resistance_Homo sapiens_hsa049310.90907079
36Dopaminergic synapse_Homo sapiens_hsa047280.86666026
37Ovarian steroidogenesis_Homo sapiens_hsa049130.86639165
38Acute myeloid leukemia_Homo sapiens_hsa052210.86597280
39Adherens junction_Homo sapiens_hsa045200.86184205
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85931010
41GnRH signaling pathway_Homo sapiens_hsa049120.85749336
42mTOR signaling pathway_Homo sapiens_hsa041500.82102448
43Long-term potentiation_Homo sapiens_hsa047200.80888528
44Peroxisome_Homo sapiens_hsa041460.80832469
45Arginine and proline metabolism_Homo sapiens_hsa003300.79356684
46Bile secretion_Homo sapiens_hsa049760.76883308
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73915667
48Nicotine addiction_Homo sapiens_hsa050330.71757344
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70238007
50Mineral absorption_Homo sapiens_hsa049780.69131721
51Synaptic vesicle cycle_Homo sapiens_hsa047210.69026816
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68965543
53cAMP signaling pathway_Homo sapiens_hsa040240.68880357
54Pancreatic secretion_Homo sapiens_hsa049720.66494075
55Gap junction_Homo sapiens_hsa045400.64618161
56Endometrial cancer_Homo sapiens_hsa052130.59387079
57Melanogenesis_Homo sapiens_hsa049160.58131155
58Gastric acid secretion_Homo sapiens_hsa049710.57619932
59Circadian entrainment_Homo sapiens_hsa047130.57295896
60Choline metabolism in cancer_Homo sapiens_hsa052310.53801434
61Glutamatergic synapse_Homo sapiens_hsa047240.53583326
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53217609
63N-Glycan biosynthesis_Homo sapiens_hsa005100.53090555
64Oxytocin signaling pathway_Homo sapiens_hsa049210.52767497
65* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52115268
66Fatty acid degradation_Homo sapiens_hsa000710.51978248
67ErbB signaling pathway_Homo sapiens_hsa040120.51313152
68Platelet activation_Homo sapiens_hsa046110.48351404
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47483932
70VEGF signaling pathway_Homo sapiens_hsa043700.47479732
71Fructose and mannose metabolism_Homo sapiens_hsa000510.45136919
72MicroRNAs in cancer_Homo sapiens_hsa052060.44274802
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43843771
74Vibrio cholerae infection_Homo sapiens_hsa051100.42093602
75FoxO signaling pathway_Homo sapiens_hsa040680.41327930
76Calcium signaling pathway_Homo sapiens_hsa040200.41282540
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41057454
78Arachidonic acid metabolism_Homo sapiens_hsa005900.40671099
79Pathways in cancer_Homo sapiens_hsa052000.39292615
80Proteoglycans in cancer_Homo sapiens_hsa052050.38350357
81Histidine metabolism_Homo sapiens_hsa003400.37392756
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35467770
83beta-Alanine metabolism_Homo sapiens_hsa004100.33546283
84Arginine biosynthesis_Homo sapiens_hsa002200.32412907
85Linoleic acid metabolism_Homo sapiens_hsa005910.30873316
86PPAR signaling pathway_Homo sapiens_hsa033200.30141728
87Taste transduction_Homo sapiens_hsa047420.29716547
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29616360
89Oocyte meiosis_Homo sapiens_hsa041140.28810491
90Inositol phosphate metabolism_Homo sapiens_hsa005620.28649247
91Cocaine addiction_Homo sapiens_hsa050300.26855957
92MAPK signaling pathway_Homo sapiens_hsa040100.24974625
93Bladder cancer_Homo sapiens_hsa052190.24905989
94Thyroid cancer_Homo sapiens_hsa052160.24433779
95Amphetamine addiction_Homo sapiens_hsa050310.23844828
96Rap1 signaling pathway_Homo sapiens_hsa040150.23101403
97Chronic myeloid leukemia_Homo sapiens_hsa052200.22409193
98Focal adhesion_Homo sapiens_hsa045100.20709057
99Colorectal cancer_Homo sapiens_hsa052100.20583255
100Dilated cardiomyopathy_Homo sapiens_hsa054140.20509354

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