KLK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)9.50237532
2neurofilament cytoskeleton organization (GO:0060052)9.30246927
3import into cell (GO:0098657)8.08635862
4adenosine metabolic process (GO:0046085)7.89890673
5protein autoprocessing (GO:0016540)7.86816792
6adaptation of signaling pathway (GO:0023058)7.61926289
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060527.46478940
8linoleic acid metabolic process (GO:0043651)7.37114700
9positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)6.29738381
10retinal metabolic process (GO:0042574)6.01100126
11positive regulation of chemokine secretion (GO:0090197)5.78210825
12artery development (GO:0060840)5.62124143
13regulation of microtubule-based movement (GO:0060632)5.58930308
14intermediate filament organization (GO:0045109)5.58142380
15phospholipid scrambling (GO:0017121)5.49621331
16fructose metabolic process (GO:0006000)5.41143483
17prostate gland epithelium morphogenesis (GO:0060740)5.31875256
18biotin metabolic process (GO:0006768)5.25627858
19detection of temperature stimulus (GO:0016048)5.20738430
20regulation of receptor binding (GO:1900120)5.13424227
21epithelial cell maturation (GO:0002070)5.11323291
22regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.07594331
23lung lobe morphogenesis (GO:0060463)5.03539465
24regulation of sensory perception (GO:0051931)4.98230106
25regulation of sensory perception of pain (GO:0051930)4.98230106
26regulation of chemokine secretion (GO:0090196)4.97470967
27endothelial cell chemotaxis (GO:0035767)4.95354906
28regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.78313356
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70499922
30positive regulation of steroid hormone secretion (GO:2000833)4.69019565
31toxin transport (GO:1901998)4.63992726
32regulation of viral entry into host cell (GO:0046596)4.63330941
33protein homotrimerization (GO:0070207)4.62371489
34positive regulation of keratinocyte differentiation (GO:0045618)4.61469652
35long-chain fatty acid biosynthetic process (GO:0042759)4.57845675
36alpha-linolenic acid metabolic process (GO:0036109)4.47910917
37intestinal epithelial cell development (GO:0060576)4.40406589
38axon development (GO:0061564)4.36304101
39mitotic cell cycle arrest (GO:0071850)4.33893503
40copper ion transport (GO:0006825)4.29106212
41hypotonic response (GO:0006971)4.20358338
42polyol catabolic process (GO:0046174)3.90581671
43peptide cross-linking (GO:0018149)3.81513872
44lipoxygenase pathway (GO:0019372)3.73020947
45pharyngeal system development (GO:0060037)3.71538761
46insulin-like growth factor receptor signaling pathway (GO:0048009)3.71485770
47extracellular matrix assembly (GO:0085029)3.65433362
48polyamine biosynthetic process (GO:0006596)3.59155903
49plasma membrane repair (GO:0001778)3.54387951
50regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.52023573
51retina homeostasis (GO:0001895)3.50094826
52reproductive behavior (GO:0019098)3.48298741
53branched-chain amino acid catabolic process (GO:0009083)3.40652439
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.38806072
55chemical homeostasis within a tissue (GO:0048875)3.33783929
56response to testosterone (GO:0033574)3.32876450
57regulation of fatty acid beta-oxidation (GO:0031998)3.25692744
58carnitine shuttle (GO:0006853)3.25035931
59negative regulation of protein localization to cell surface (GO:2000009)3.23876705
60intermediate filament cytoskeleton organization (GO:0045104)3.21945981
61regulation of steroid hormone secretion (GO:2000831)3.21616182
62retinol metabolic process (GO:0042572)3.21181719
63sequestering of extracellular ligand from receptor (GO:0035581)3.18365491
64face development (GO:0060324)3.14510410
65positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.13864632
66positive regulation of epidermal cell differentiation (GO:0045606)3.12324860
67negative regulation of stress fiber assembly (GO:0051497)3.11399920
68intermediate filament-based process (GO:0045103)3.08998582
69UDP-N-acetylglucosamine metabolic process (GO:0006047)3.07601828
70quaternary ammonium group transport (GO:0015697)3.05602861
71epithelial cell differentiation involved in prostate gland development (GO:0060742)3.03658027
72Golgi transport vesicle coating (GO:0048200)3.02425145
73COPI coating of Golgi vesicle (GO:0048205)3.02425145
74long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.02169542
75endocrine hormone secretion (GO:0060986)3.01236386
76fatty acid elongation (GO:0030497)3.00757451
77lung vasculature development (GO:0060426)2.98780272
78fibroblast migration (GO:0010761)2.97702043
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.97028447
80positive regulation of glycolytic process (GO:0045821)2.96458299
81cellular carbohydrate catabolic process (GO:0044275)2.96360877
82positive regulation of glycogen biosynthetic process (GO:0045725)2.95066904
83lung epithelial cell differentiation (GO:0060487)2.94237087
84carnitine transmembrane transport (GO:1902603)2.94035368
85positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.93711255
86mammary gland development (GO:0030879)2.92857824
87branched-chain amino acid metabolic process (GO:0009081)2.91923912
88Golgi to plasma membrane transport (GO:0006893)2.91221102
89response to cold (GO:0009409)2.89658224
90negative regulation of fatty acid transport (GO:2000192)2.87413438
91regulation of fatty acid oxidation (GO:0046320)2.85728760
92lung cell differentiation (GO:0060479)2.84680670
93zinc ion transmembrane transport (GO:0071577)2.84515534
94alditol metabolic process (GO:0019400)2.83663513
95tonic smooth muscle contraction (GO:0014820)2.78300505
96regulation of protein localization to cell surface (GO:2000008)2.78139055
97lung secretory cell differentiation (GO:0061140)2.75894688
98fatty-acyl-CoA biosynthetic process (GO:0046949)2.72604018
99regulation of tight junction assembly (GO:2000810)2.70351302
100iron ion import (GO:0097286)10.9009024

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.64977420
2* AR_21909140_ChIP-Seq_LNCAP_Human4.95182641
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.83040847
4PIAS1_25552417_ChIP-Seq_VCAP_Human4.73226905
5* AR_21915096_ChIP-Seq_LNCaP-1F5_Human4.40099811
6* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human4.10722542
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.50045581
8* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.96769513
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.87175061
10AR_21572438_ChIP-Seq_LNCaP_Human2.80521472
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.59871319
12CHD1_26751641_Chip-Seq_LNCaP_Human2.55052325
13IGF1R_20145208_ChIP-Seq_DFB_Human2.38254277
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32892193
15FOXA1_25552417_ChIP-Seq_VCAP_Human2.26243434
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.20739664
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.18392954
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15721486
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.01488523
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.00590091
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.93185177
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92207857
23ZNF263_19887448_ChIP-Seq_K562_Human1.88902082
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.86114541
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81544836
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.75732445
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73083340
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72699584
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69990788
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.67350554
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63442082
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63424232
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.63422678
34* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58615001
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.54981309
36CLOCK_20551151_ChIP-Seq_293T_Human1.51252895
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48996373
38* CREB1_26743006_Chip-Seq_LNCaP_Human1.48953456
39RACK7_27058665_Chip-Seq_MCF-7_Human1.44081326
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38172670
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.35312512
42* FOXO3_23340844_ChIP-Seq_DLD1_Human1.32624064
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31479187
44EGR1_19032775_ChIP-ChIP_M12_Human1.31250996
45FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.31191145
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30217590
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28776065
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.27761173
49AHR_22903824_ChIP-Seq_MCF-7_Human1.24801931
50* GATA3_24758297_ChIP-Seq_MCF-7_Human1.23999920
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.23755037
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18657581
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16920967
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.15131132
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15029002
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13776999
57EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13017648
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11761597
59NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.11344506
60TCF7_22412390_ChIP-Seq_EML_Mouse1.06584837
61CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05854394
62STAT1_20625510_ChIP-Seq_HELA_Human1.04819927
63DROSHA_22980978_ChIP-Seq_HELA_Human1.01775435
64YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01642027
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01105791
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01011913
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97271865
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95166055
69ARNT_22903824_ChIP-Seq_MCF-7_Human0.94144821
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93501769
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93501769
72GATA4_25053715_ChIP-Seq_YYC3_Human0.92865635
73GATA6_25053715_ChIP-Seq_YYC3_Human0.91882271
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90694494
75GATA2_21666600_ChIP-Seq_HMVEC_Human0.90457626
76VDR_24787735_ChIP-Seq_THP-1_Human0.90355100
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90069211
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88875661
79ERG_21242973_ChIP-ChIP_JURKAT_Human0.88824881
80RING1B_27294783_Chip-Seq_NPCs_Mouse0.87070018
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86549292
82GATA1_19941826_ChIP-Seq_K562_Human0.84797305
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84691860
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84524422
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83982305
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82310275
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81008869
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81008869
89EP300_21415370_ChIP-Seq_HL-1_Mouse0.80389729
90TCF4_18268006_ChIP-ChIP_LS174T_Human0.79941528
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79502821
92NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79415402
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.78979591
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.76953253
95TBX20_22328084_ChIP-Seq_HEART_Mouse0.76953253
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76048971
97SOX2_20726797_ChIP-Seq_SW620_Human0.75942183
98GF1B_26923725_Chip-Seq_HPCs_Mouse0.75843376
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75353413
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74060371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.79525367
2MP0004858_abnormal_nervous_system4.75574311
3MP0002736_abnormal_nociception_after4.04386427
4MP0002166_altered_tumor_susceptibility3.66433261
5MP0005310_abnormal_salivary_gland3.51400299
6MP0004043_abnormal_pH_regulation3.38393712
7MP0005647_abnormal_sex_gland3.14821214
8MP0002822_catalepsy2.87754858
9MP0005167_abnormal_blood-brain_barrier2.86692426
10MP0004510_myositis2.71559487
11MP0002009_preneoplasia2.63076454
12MP0001968_abnormal_touch/_nociception2.60913577
13MP0002006_tumorigenesis2.43768114
14MP0000538_abnormal_urinary_bladder2.41061518
15MP0001664_abnormal_digestion2.37616620
16MP0010386_abnormal_urinary_bladder2.29774212
17MP0001756_abnormal_urination2.29341199
18MP0000537_abnormal_urethra_morphology2.24319955
19MP0000613_abnormal_salivary_gland2.23557015
20MP0004947_skin_inflammation2.04915538
21MP0002735_abnormal_chemical_nociception2.04434642
22MP0005670_abnormal_white_adipose2.01917708
23MP0002234_abnormal_pharynx_morphology1.98763585
24MP0003045_fibrosis1.97333289
25MP0003705_abnormal_hypodermis_morpholog1.81896002
26MP0000230_abnormal_systemic_arterial1.65911226
27MP0003315_abnormal_perineum_morphology1.62990576
28MP0005367_renal/urinary_system_phenotyp1.62003528
29MP0000516_abnormal_urinary_system1.62003528
30MP0004036_abnormal_muscle_relaxation1.61960268
31MP0001873_stomach_inflammation1.60317410
32MP0001765_abnormal_ion_homeostasis1.58729219
33MP0000462_abnormal_digestive_system1.58500952
34MP0003566_abnormal_cell_adhesion1.48407100
35MP0003866_abnormal_defecation1.42322948
36MP0005220_abnormal_exocrine_pancreas1.41743317
37MP0001958_emphysema1.31085620
38MP0005085_abnormal_gallbladder_physiolo1.27207472
39MP0010234_abnormal_vibrissa_follicle1.25160709
40MP0004264_abnormal_extraembryonic_tissu1.24313682
41MP0003879_abnormal_hair_cell1.21513086
42MP0005330_cardiomyopathy1.19129325
43MP0000534_abnormal_ureter_morphology1.18351021
44MP0000627_abnormal_mammary_gland1.13487981
45MP0005076_abnormal_cell_differentiation1.07975961
46MP0001764_abnormal_homeostasis1.07907089
47MP0002837_dystrophic_cardiac_calcinosis1.04982149
48MP0002168_other_aberrant_phenotype1.04863252
49MP0001666_abnormal_nutrient_absorption1.01869794
50MP0001919_abnormal_reproductive_system1.01667256
51MP0002090_abnormal_vision0.99076219
52MP0000566_synostosis0.98170555
53MP0003868_abnormal_feces_composition0.96034127
54MP0005636_abnormal_mineral_homeostasis0.95252823
55MP0005666_abnormal_adipose_tissue0.92349168
56MP0008961_abnormal_basal_metabolism0.85464506
57MP0002876_abnormal_thyroid_physiology0.85267548
58MP0005503_abnormal_tendon_morphology0.84218186
59MP0002733_abnormal_thermal_nociception0.82956334
60MP0000955_abnormal_spinal_cord0.82578623
61MP0005187_abnormal_penis_morphology0.82305299
62MP0000858_altered_metastatic_potential0.81958093
63MP0005319_abnormal_enzyme/_coenzyme0.80432048
64MP0005164_abnormal_response_to0.79493367
65MP0005408_hypopigmentation0.79357697
66MP0005395_other_phenotype0.79062738
67MP0002108_abnormal_muscle_morphology0.78854348
68MP0002115_abnormal_skeleton_extremities0.77975582
69MP0005248_abnormal_Harderian_gland0.76650882
70MP0000432_abnormal_head_morphology0.75942091
71MP0001970_abnormal_pain_threshold0.75128337
72MP0005646_abnormal_pituitary_gland0.72961937
73MP0005620_abnormal_muscle_contractility0.72001355
74MP0004145_abnormal_muscle_electrophysio0.71697311
75MP0003936_abnormal_reproductive_system0.69138031
76MP0004084_abnormal_cardiac_muscle0.69085610
77MP0002877_abnormal_melanocyte_morpholog0.68143946
78MP0005381_digestive/alimentary_phenotyp0.68049993
79MP0004742_abnormal_vestibular_system0.68001466
80MP0004019_abnormal_vitamin_homeostasis0.66966281
81MP0003633_abnormal_nervous_system0.65324356
82MP0004883_abnormal_blood_vessel0.65154999
83MP0002693_abnormal_pancreas_physiology0.63112904
84MP0001501_abnormal_sleep_pattern0.62744123
85MP0001731_abnormal_postnatal_growth0.62433584
86MP0000371_diluted_coat_color0.61727746
87MP0003942_abnormal_urinary_system0.61149051
88MP0002075_abnormal_coat/hair_pigmentati0.60960741
89MP0001879_abnormal_lymphatic_vessel0.60604717
90MP0005376_homeostasis/metabolism_phenot0.58507458
91MP0000163_abnormal_cartilage_morphology0.57181940
92MP0010771_integument_phenotype0.56951490
93MP0002136_abnormal_kidney_physiology0.56478432
94MP0005409_darkened_coat_color0.56128269
95MP0001727_abnormal_embryo_implantation0.55425510
96MP0001186_pigmentation_phenotype0.55345994
97MP0005595_abnormal_vascular_smooth0.55316104
98MP0003091_abnormal_cell_migration0.55273266
99MP0009384_cardiac_valve_regurgitation0.55100083
100MP0002896_abnormal_bone_mineralization0.54946572

Predicted human phenotypes

RankGene SetZ-score
1Aortic aneurysm (HP:0004942)8.33662021
2Neoplasm of the heart (HP:0100544)7.65630815
3Amelogenesis imperfecta (HP:0000705)6.86030502
4Aortic dissection (HP:0002647)6.54793766
5Malnutrition (HP:0004395)6.37900535
6Abdominal situs inversus (HP:0003363)4.61306443
7Abnormality of abdominal situs (HP:0011620)4.61306443
8Aortic regurgitation (HP:0001659)4.45997773
9Abnormality of the axillary hair (HP:0100134)4.35562149
10Abnormality of secondary sexual hair (HP:0009888)4.35562149
11Sparse lateral eyebrow (HP:0005338)3.82476169
12Gastrointestinal dysmotility (HP:0002579)3.56557016
13Broad face (HP:0000283)3.55110475
14Abnormal tarsal ossification (HP:0008369)3.40331245
15Bundle branch block (HP:0011710)3.39417767
16Intrahepatic cholestasis (HP:0001406)3.35901758
17Right ventricular cardiomyopathy (HP:0011663)3.30458034
18Obstructive sleep apnea (HP:0002870)3.30072886
19Flat acetabular roof (HP:0003180)3.24959291
20Abnormality of the distal phalanx of the thumb (HP:0009617)3.12597074
21Hyperparathyroidism (HP:0000843)2.97197317
22Dysmetric saccades (HP:0000641)2.96657686
23Abnormal foot bone ossification (HP:0010675)2.95865253
24Aneurysm (HP:0002617)2.94317186
25Short 1st metacarpal (HP:0010034)2.86813573
26Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.86813573
27Abnormality of the proximal phalanges of the hand (HP:0009834)2.81837540
28Hyperglycinuria (HP:0003108)2.81534673
29Stroke (HP:0001297)2.81295890
30Bronchomalacia (HP:0002780)2.77188868
31Aplasia of the musculature (HP:0100854)2.75671124
32Laryngomalacia (HP:0001601)2.66356559
33Abnormal ossification of hand bones (HP:0005921)2.63766611
34Shallow orbits (HP:0000586)2.59325291
35Abnormality of the 1st metacarpal (HP:0010009)2.59164083
36Abnormal cartilage morphology (HP:0002763)2.54390427
37Germ cell neoplasia (HP:0100728)2.54292080
38Abnormality of carpal bone ossification (HP:0006257)2.53718003
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.53151033
40Advanced eruption of teeth (HP:0006288)2.52670500
41Long toe (HP:0010511)2.45458920
42Hypoplastic nipples (HP:0002557)2.44826698
43Short phalanx of the thumb (HP:0009660)2.42196334
44Abnormal hand bone ossification (HP:0010660)2.41660864
45Overgrowth (HP:0001548)2.38841959
46Abnormality of the phalanges of the hallux (HP:0010057)2.38404781
47Renal tubular acidosis (HP:0001947)2.36881075
48Skin nodule (HP:0200036)2.31753499
49Abnormality of the distal phalanges of the toes (HP:0010182)2.31223885
50Bicuspid aortic valve (HP:0001647)2.29756307
51Fibular aplasia (HP:0002990)2.26806290
52Generalized hypopigmentation of hair (HP:0011358)2.24645320
53Lip pit (HP:0100267)2.22814510
54Decreased circulating renin level (HP:0003351)2.22189027
55Breast hypoplasia (HP:0003187)2.19506634
56Anal stenosis (HP:0002025)2.18144143
57Flattened epiphyses (HP:0003071)2.16079100
58Short humerus (HP:0005792)2.09112581
59Persistence of primary teeth (HP:0006335)2.00682345
60Abnormality of the fingertips (HP:0001211)2.00070364
61Rectal prolapse (HP:0002035)1.99526051
62Abnormality of serine family amino acid metabolism (HP:0010894)1.98650971
63Abnormality of glycine metabolism (HP:0010895)1.98650971
64Hydroureter (HP:0000072)1.98327908
65Gonadotropin excess (HP:0000837)1.98064390
66Prolonged QT interval (HP:0001657)1.97485592
67Sensorimotor neuropathy (HP:0007141)1.96651333
68Pulmonary artery stenosis (HP:0004415)1.95419657
69Ketoacidosis (HP:0001993)1.89734452
70Short nail (HP:0001799)1.87586244
71Broad metatarsal (HP:0001783)1.87342256
72Absent hand (HP:0004050)1.87044598
73Severe Myopia (HP:0011003)1.84252615
74Segmental peripheral demyelination/remyelination (HP:0003481)1.83115416
75Congenital glaucoma (HP:0001087)1.82089433
76Hypoplasia of the ulna (HP:0003022)1.81425185
77Tracheomalacia (HP:0002779)1.81357339
78Aplasia/hypoplasia of the humerus (HP:0006507)1.80715001
79Arthropathy (HP:0003040)1.79226290
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79035481
81Shawl scrotum (HP:0000049)1.78969238
82Syncope (HP:0001279)1.77991236
83Omphalocele (HP:0001539)1.76690442
84Bulbar palsy (HP:0001283)1.76559709
85Genetic anticipation (HP:0003743)1.75562080
86Heart block (HP:0012722)1.74730787
87Hydronephrosis (HP:0000126)1.74242854
88Hypoplasia of the odontoid process (HP:0003311)1.70670175
89Aplasia/Hypoplasia of the ulna (HP:0006495)1.69972110
90Synostosis of carpal bones (HP:0005048)1.69797125
91Abnormal atrioventricular conduction (HP:0005150)1.68538913
92Abnormality of the odontoid process (HP:0003310)1.67036735
93Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66775728
94Glossoptosis (HP:0000162)1.66690638
95Short clavicles (HP:0000894)1.66508895
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.65721011
97Hyporeflexia of lower limbs (HP:0002600)1.65146618
98Abnormality of the nasal septum (HP:0000419)1.64813965
99Aplasia/Hypoplasia of the fibula (HP:0006492)1.63683697
100Abnormality of the 2nd finger (HP:0004100)1.62458591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT38.37375098
2MYLK5.89769780
3EEF2K4.69086138
4CAMK1D4.22821789
5CAMK1G3.08419247
6TRIB32.81030327
7DMPK2.53102952
8PRKD32.35991464
9PAK22.30036167
10STK392.28135645
11MAPKAPK32.13297863
12CDC42BPA2.01882116
13EPHA31.99333529
14TNK21.94965846
15WNK41.89623649
16SGK4941.64170266
17SGK2231.64170266
18SGK21.60737359
19PKN21.44265132
20SMG11.31334592
21TAOK31.30989783
22SIK11.27737822
23MARK21.20654261
24ICK1.20650276
25TTN1.18417892
26LATS11.18110931
27SGK31.14291741
28FER1.06289866
29TESK21.05917252
30STK380.95570921
31MAP3K130.94950160
32STK38L0.90022941
33PRKAA20.89291885
34LMTK20.87502834
35CDK120.84434215
36MTOR0.84030808
37TESK10.82756719
38ERN10.82272679
39FRK0.80561597
40RPS6KB20.79073276
41DAPK30.78064971
42DAPK20.75012365
43ACVR1B0.74205832
44NLK0.73080767
45TRPM70.72900611
46WNK10.70214097
47MAPK150.68962672
48CAMK10.66318141
49GSK3A0.66044419
50PAK30.65578489
51CAMKK10.64414190
52PIK3CA0.62502241
53PRKAA10.61992420
54RPS6KA20.57695433
55CAMKK20.57442841
56HIPK20.50944403
57MAPKAPK50.48646494
58TAF10.48633966
59PRKD20.46433572
60NEK90.45153634
61MAPK130.42740598
62MELK0.38318400
63EPHB10.37648017
64EPHA20.37246795
65NEK60.34590484
66PIK3CG0.33212263
67ILK0.33184417
68TAOK10.30449134
69SGK10.29579605
70DDR20.29362060
71CHUK0.28966929
72ERBB20.28713595
73BRSK20.27105517
74ROCK10.26889151
75MAPK10.25021525
76MAP2K20.24572387
77PRKCH0.24465554
78YES10.23767176
79PDK10.23704342
80MAPK40.23027718
81SCYL20.22317576
82RIPK10.21818338
83MAPKAPK20.20875820
84MOS0.19380361
85RET0.19149033
86MAPK120.17726334
87PDPK10.16240206
88EIF2AK20.16030217
89PDGFRB0.15551148
90GRK70.15494519
91GSK3B0.15323133
92MAPK140.14507014
93MAP2K10.14249126
94FGFR40.13603241
95PDGFRA0.12847218
96AKT10.11464639
97PTK60.10835907
98MAPK80.10611175
99JAK10.10482603
100PHKG20.09676564

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046143.44936752
2Fatty acid biosynthesis_Homo sapiens_hsa000613.06885313
3Vascular smooth muscle contraction_Homo sapiens_hsa042702.63648947
4Histidine metabolism_Homo sapiens_hsa003402.62491554
5beta-Alanine metabolism_Homo sapiens_hsa004102.55431031
6Fructose and mannose metabolism_Homo sapiens_hsa000512.53919100
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40575782
8Arginine and proline metabolism_Homo sapiens_hsa003302.31795872
9Mineral absorption_Homo sapiens_hsa049782.24733577
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.15680514
11Phenylalanine metabolism_Homo sapiens_hsa003602.10444589
12Fatty acid metabolism_Homo sapiens_hsa012122.06035530
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99482602
14Vitamin digestion and absorption_Homo sapiens_hsa049771.90196016
15* Prostate cancer_Homo sapiens_hsa052151.77826527
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77536132
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.66475640
18Arachidonic acid metabolism_Homo sapiens_hsa005901.50095224
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48120741
20Longevity regulating pathway - mammal_Homo sapiens_hsa042111.46708116
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45327565
22Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42341161
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39901120
24mTOR signaling pathway_Homo sapiens_hsa041501.39743019
25AMPK signaling pathway_Homo sapiens_hsa041521.35232121
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34938047
27Bile secretion_Homo sapiens_hsa049761.31507304
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31203775
29Propanoate metabolism_Homo sapiens_hsa006401.28396865
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.28363510
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26994194
32Fatty acid degradation_Homo sapiens_hsa000711.23109219
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19603330
34Cocaine addiction_Homo sapiens_hsa050301.19185282
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.16178843
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15741477
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13121146
38Insulin resistance_Homo sapiens_hsa049311.12540000
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11207461
40Circadian rhythm_Homo sapiens_hsa047101.10069248
41Lysine degradation_Homo sapiens_hsa003101.09149394
42Amphetamine addiction_Homo sapiens_hsa050311.08051170
43Tryptophan metabolism_Homo sapiens_hsa003801.06539480
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05451132
45ABC transporters_Homo sapiens_hsa020101.05125350
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00500172
47FoxO signaling pathway_Homo sapiens_hsa040680.99476240
48MicroRNAs in cancer_Homo sapiens_hsa052060.99108888
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97002126
50Tight junction_Homo sapiens_hsa045300.96861323
51Arginine biosynthesis_Homo sapiens_hsa002200.96823500
52Ovarian steroidogenesis_Homo sapiens_hsa049130.94081703
53Estrogen signaling pathway_Homo sapiens_hsa049150.91721855
54Tyrosine metabolism_Homo sapiens_hsa003500.91536581
55Glucagon signaling pathway_Homo sapiens_hsa049220.87268069
56Peroxisome_Homo sapiens_hsa041460.85964381
57PPAR signaling pathway_Homo sapiens_hsa033200.84656478
58Renin secretion_Homo sapiens_hsa049240.83087240
59Insulin secretion_Homo sapiens_hsa049110.80739257
60Serotonergic synapse_Homo sapiens_hsa047260.77367935
61Choline metabolism in cancer_Homo sapiens_hsa052310.75844886
62Adherens junction_Homo sapiens_hsa045200.74556558
63Insulin signaling pathway_Homo sapiens_hsa049100.74480817
64Oxytocin signaling pathway_Homo sapiens_hsa049210.74441608
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74048742
66cAMP signaling pathway_Homo sapiens_hsa040240.72796851
67Salivary secretion_Homo sapiens_hsa049700.72697941
68Pyruvate metabolism_Homo sapiens_hsa006200.71458491
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.69866047
70Butanoate metabolism_Homo sapiens_hsa006500.68087828
71Notch signaling pathway_Homo sapiens_hsa043300.65351399
72VEGF signaling pathway_Homo sapiens_hsa043700.64798300
73Thyroid hormone synthesis_Homo sapiens_hsa049180.63561640
74Endometrial cancer_Homo sapiens_hsa052130.62421533
75Steroid biosynthesis_Homo sapiens_hsa001000.61991769
76Glutathione metabolism_Homo sapiens_hsa004800.60861032
77Dilated cardiomyopathy_Homo sapiens_hsa054140.59934158
78Focal adhesion_Homo sapiens_hsa045100.59709503
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54300253
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.54069662
81Cholinergic synapse_Homo sapiens_hsa047250.50478291
82Linoleic acid metabolism_Homo sapiens_hsa005910.50199595
83Long-term depression_Homo sapiens_hsa047300.47110008
84Pancreatic secretion_Homo sapiens_hsa049720.46430073
85Type II diabetes mellitus_Homo sapiens_hsa049300.45149402
86Bladder cancer_Homo sapiens_hsa052190.44987545
87Sphingolipid metabolism_Homo sapiens_hsa006000.44677362
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41558274
89Retinol metabolism_Homo sapiens_hsa008300.39643526
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.38800681
91GnRH signaling pathway_Homo sapiens_hsa049120.34572719
92Dopaminergic synapse_Homo sapiens_hsa047280.33230934
93Protein digestion and absorption_Homo sapiens_hsa049740.31387308
94Acute myeloid leukemia_Homo sapiens_hsa052210.30577519
95Proteoglycans in cancer_Homo sapiens_hsa052050.30314960
96Influenza A_Homo sapiens_hsa051640.27404887
97Vitamin B6 metabolism_Homo sapiens_hsa007500.27352887
98Amoebiasis_Homo sapiens_hsa051460.26044650
99Fatty acid elongation_Homo sapiens_hsa000620.23555287
100Hepatitis C_Homo sapiens_hsa051600.23464115

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