KLK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in prostate gland morphogenesis (GO:0060442)9.12851459
2positive regulation of collagen biosynthetic process (GO:0032967)7.83773680
3positive regulation of collagen metabolic process (GO:0010714)7.46468062
4endothelial cell chemotaxis (GO:0035767)7.46270330
5linoleic acid metabolic process (GO:0043651)7.09517820
6regulation of collagen biosynthetic process (GO:0032965)6.95105972
7phospholipid scrambling (GO:0017121)6.63794753
8artery development (GO:0060840)6.54071092
9import into cell (GO:0098657)6.50906121
10positive regulation of chemokine secretion (GO:0090197)6.46929992
11biotin metabolic process (GO:0006768)6.07192104
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.06954347
13regulation of collagen metabolic process (GO:0010712)6.04872073
14long-chain fatty acid biosynthetic process (GO:0042759)6.03726404
15endodermal cell differentiation (GO:0035987)5.87015932
16positive regulation of biomineral tissue development (GO:0070169)5.81325435
17regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.75880974
18regulation of chemokine secretion (GO:0090196)5.68718778
19regulation of receptor binding (GO:1900120)5.58835084
20bone trabecula formation (GO:0060346)5.55672873
21positive regulation of steroid hormone secretion (GO:2000833)5.55571750
22positive regulation of multicellular organismal metabolic process (GO:0044253)5.55174621
23positive regulation of keratinocyte differentiation (GO:0045618)5.33642955
24protein autoprocessing (GO:0016540)5.33468607
25prostate gland epithelium morphogenesis (GO:0060740)5.23703747
26regulation of biomineral tissue development (GO:0070167)5.23418884
27lipoxygenase pathway (GO:0019372)5.18723364
28cell-substrate junction assembly (GO:0007044)5.15079418
29regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)5.15031986
30mitotic cell cycle arrest (GO:0071850)4.82656561
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.70974962
32regulation of multicellular organismal metabolic process (GO:0044246)4.64801208
33chondrocyte differentiation (GO:0002062)4.51290263
34carnitine shuttle (GO:0006853)4.51026360
35epithelial cell maturation (GO:0002070)4.32401648
36lung lobe morphogenesis (GO:0060463)4.30303088
37epithelial to mesenchymal transition (GO:0001837)4.29503891
38insulin-like growth factor receptor signaling pathway (GO:0048009)4.27253132
39C4-dicarboxylate transport (GO:0015740)4.22343449
40pharyngeal system development (GO:0060037)4.21625375
41regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.09296456
42regulation of female gonad development (GO:2000194)4.06622716
43* extracellular matrix disassembly (GO:0022617)4.05139994
44carnitine transmembrane transport (GO:1902603)3.91983263
45positive regulation of hair cycle (GO:0042635)3.90977238
46positive regulation of hair follicle development (GO:0051798)3.90977238
47ovulation cycle (GO:0042698)3.90124473
48fatty acid transmembrane transport (GO:1902001)3.88619075
49acetyl-CoA metabolic process (GO:0006084)3.84536401
50regulation of steroid hormone secretion (GO:2000831)3.70007746
51positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.63233891
52positive regulation of epidermal cell differentiation (GO:0045606)3.59294368
53regulation of viral entry into host cell (GO:0046596)3.58363169
54positive regulation of histone deacetylation (GO:0031065)3.56908472
55lateral sprouting from an epithelium (GO:0060601)3.55870829
56short-term memory (GO:0007614)3.54455751
57lung epithelial cell differentiation (GO:0060487)3.54214405
58collagen catabolic process (GO:0030574)3.54128267
59positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.53519325
60carnitine transport (GO:0015879)3.51581088
61amino-acid betaine transport (GO:0015838)3.51581088
62neurofilament cytoskeleton organization (GO:0060052)3.50477983
63response to testosterone (GO:0033574)3.50426990
64somatic stem cell division (GO:0048103)3.49719632
65fibroblast migration (GO:0010761)3.47337326
66positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.46886450
67intestinal epithelial cell development (GO:0060576)3.43065296
68collagen metabolic process (GO:0032963)3.41836327
69regulation of hair follicle development (GO:0051797)3.40110500
70lateral ventricle development (GO:0021670)3.40010970
71lung cell differentiation (GO:0060479)3.39712655
72quaternary ammonium group transport (GO:0015697)3.39148942
73glucocorticoid receptor signaling pathway (GO:0042921)3.35473937
74regulation of fatty acid beta-oxidation (GO:0031998)3.33898455
75long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.26956655
76multicellular organismal catabolic process (GO:0044243)3.23468184
77multicellular organismal macromolecule metabolic process (GO:0044259)3.19358733
78toxin transport (GO:1901998)3.16648473
79copper ion transport (GO:0006825)3.15189161
80face development (GO:0060324)3.12248941
81chemical homeostasis within a tissue (GO:0048875)3.11614460
82plasma membrane repair (GO:0001778)3.08633646
83negative regulation of protein localization to plasma membrane (GO:1903077)3.07642499
84acyl-CoA biosynthetic process (GO:0071616)3.02686027
85thioester biosynthetic process (GO:0035384)3.02686027
86inositol phosphate-mediated signaling (GO:0048016)3.02346237
87regulation of organ morphogenesis (GO:2000027)3.01606764
88regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.01117196
89adaptation of signaling pathway (GO:0023058)3.00303920
90tooth mineralization (GO:0034505)26.1967532
91multicellular organismal metabolic process (GO:0044236)2.99025825
92endochondral ossification (GO:0001958)2.97940821
93replacement ossification (GO:0036075)2.97940821
94fatty-acyl-CoA biosynthetic process (GO:0046949)2.96893157
95interkinetic nuclear migration (GO:0022027)2.96841237
96sodium ion export (GO:0071436)2.94784282
97regulation of membrane lipid distribution (GO:0097035)2.94780302
98regulation of ARF protein signal transduction (GO:0032012)2.94570043
99nerve growth factor signaling pathway (GO:0038180)2.94538675
100osteoblast differentiation (GO:0001649)2.93785716
101cranial suture morphogenesis (GO:0060363)2.92590814
102positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.91943641
103mesenchymal-epithelial cell signaling (GO:0060638)2.90238603
104cellular response to ethanol (GO:0071361)2.90010747
105regulation of fatty acid oxidation (GO:0046320)2.86908275
106peptidyl-lysine dimethylation (GO:0018027)2.84303307
107retinal metabolic process (GO:0042574)2.83951439
108multicellular organismal movement (GO:0050879)2.83344219
109musculoskeletal movement (GO:0050881)2.83344219
110lung secretory cell differentiation (GO:0061140)2.81914499
111lung-associated mesenchyme development (GO:0060484)2.81216641
112epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80645549
113outer ear morphogenesis (GO:0042473)2.80606221
114negative regulation of protein localization to cell surface (GO:2000009)2.79988567
115positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.79912904
116response to parathyroid hormone (GO:0071107)2.79319244
117establishment of tissue polarity (GO:0007164)2.78502686
118establishment of planar polarity (GO:0001736)2.78502686
119opsonization (GO:0008228)2.78465893
120receptor catabolic process (GO:0032801)2.77475452
121extracellular matrix assembly (GO:0085029)2.77179804
122establishment of protein localization to Golgi (GO:0072600)2.76471769
123positive regulation of cellular amine metabolic process (GO:0033240)2.76140777
124negative regulation of sodium ion transport (GO:0010766)2.75246706
125negative regulation of smooth muscle cell differentiation (GO:0051151)2.75096318
126response to vitamin D (GO:0033280)2.74567332
127negative regulation of translation, ncRNA-mediated (GO:0040033)2.73639857
128regulation of translation, ncRNA-mediated (GO:0045974)2.73639857
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73639857
130cell migration involved in sprouting angiogenesis (GO:0002042)2.73622746
131negative regulation of fatty acid transport (GO:2000192)2.73537683
132fructose metabolic process (GO:0006000)2.72330948
133negative regulation of Notch signaling pathway (GO:0045746)2.71463311
134adenosine metabolic process (GO:0046085)2.70496852
135* organ morphogenesis (GO:0009887)2.70131952
136regulation of hippo signaling (GO:0035330)2.69636612
137corticosteroid receptor signaling pathway (GO:0031958)2.67636463
138peptidyl-tyrosine autophosphorylation (GO:0038083)2.66792464
139craniofacial suture morphogenesis (GO:0097094)2.65817186
140protein localization to endosome (GO:0036010)2.64185118
141branching involved in salivary gland morphogenesis (GO:0060445)2.64167520
142chondrocyte development (GO:0002063)2.63635328
143mammary gland development (GO:0030879)2.63607542
144positive regulation of protein deacetylation (GO:0090312)2.62574661
145positive regulation of glycogen biosynthetic process (GO:0045725)2.60770998
146regulation of water loss via skin (GO:0033561)2.60053111
147regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.60017443
148positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.60017443
149regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59748798
150synaptic vesicle docking involved in exocytosis (GO:0016081)2.59663172
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.59141445
152coenzyme A metabolic process (GO:0015936)2.59019711
153regulation of keratinocyte differentiation (GO:0045616)2.57025691
154histone H3-K9 demethylation (GO:0033169)2.56788366
155cellular potassium ion homeostasis (GO:0030007)2.55599150
156skeletal muscle fiber development (GO:0048741)2.55005500
157cell adhesion mediated by integrin (GO:0033627)2.49653037
158regulation of neuron migration (GO:2001222)2.47301914
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46701383
160iron ion import (GO:0097286)2.46266877
161regulation of mesenchymal cell apoptotic process (GO:2001053)2.40651938
162midgut development (GO:0007494)2.39803412
163lens fiber cell differentiation (GO:0070306)2.35651678
164osteoblast development (GO:0002076)2.34075483
165mesenchymal cell proliferation (GO:0010463)2.31704401
166positive regulation of Rho protein signal transduction (GO:0035025)2.31104100
167hematopoietic stem cell proliferation (GO:0071425)2.30768675
168regulation of synapse structural plasticity (GO:0051823)2.26067238
169cell junction organization (GO:0034330)2.22036818
170planar cell polarity pathway involved in neural tube closure (GO:0090179)2.19979147
171myotube cell development (GO:0014904)2.16816475
172embryonic hindlimb morphogenesis (GO:0035116)2.16384238
173renal system development (GO:0072001)2.16243193
174stem cell division (GO:0017145)2.15022740
175cell proliferation involved in metanephros development (GO:0072203)2.14515071
176regulation of hair cycle (GO:0042634)2.14490573
177desmosome organization (GO:0002934)2.12593213
178epidermis development (GO:0008544)2.12043437
179negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.11756704
180leukocyte aggregation (GO:0070486)2.11119444
181virion attachment to host cell (GO:0019062)2.10763917
182adhesion of symbiont to host cell (GO:0044650)2.10763917
183positive regulation of bone remodeling (GO:0046852)2.09478423
184positive regulation of bone resorption (GO:0045780)2.09478423
185cell surface receptor signaling pathway involved in heart development (GO:0061311)2.09432411
186regulation of transforming growth factor beta2 production (GO:0032909)2.08516552
187positive regulation of catenin import into nucleus (GO:0035413)2.03562492
188myoblast differentiation (GO:0045445)2.02737092
189positive regulation of osteoblast differentiation (GO:0045669)2.01403939
190cell junction assembly (GO:0034329)2.00976982
191membrane tubulation (GO:0097320)2.00777906
192regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.00599195
193hemidesmosome assembly (GO:0031581)16.2823143
194* odontogenesis of dentin-containing tooth (GO:0042475)14.7699307
195positive regulation of odontogenesis (GO:0042482)14.6524417
196regulation of odontogenesis of dentin-containing tooth (GO:0042487)12.6833185
197regulation of odontogenesis (GO:0042481)12.5034911
198biomineral tissue development (GO:0031214)12.4383238
199* odontogenesis (GO:0042476)10.9977040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.17387320
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.09184796
3PIAS1_25552417_ChIP-Seq_VCAP_Human3.83977388
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13995835
5FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.95536588
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.81272215
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77134859
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65810228
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62686603
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34636244
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.29217872
12DROSHA_22980978_ChIP-Seq_HELA_Human2.24324171
13* HTT_18923047_ChIP-ChIP_STHdh_Human2.24167572
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16271335
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.09838280
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.04789208
17RUNX1_27514584_Chip-Seq_MCF-7_Human1.95353897
18CHD1_26751641_Chip-Seq_LNCaP_Human1.95067010
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92682943
20RACK7_27058665_Chip-Seq_MCF-7_Human1.88142779
21CLOCK_20551151_ChIP-Seq_293T_Human1.85062229
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83626863
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83018608
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83018608
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75387234
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75221564
27TCF7_22412390_ChIP-Seq_EML_Mouse1.71686705
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.69627368
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69416257
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67910303
31* CREB1_26743006_Chip-Seq_LNCaP_Human1.66930018
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.66571188
33EZH2_22144423_ChIP-Seq_EOC_Human1.65345309
34* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63105265
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62938867
36LXR_22292898_ChIP-Seq_THP-1_Human1.62455889
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60779405
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59814214
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59492959
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59069607
41SMAD3_21741376_ChIP-Seq_HESCs_Human1.57119520
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54493063
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53968984
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53732478
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53701249
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52503714
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51726177
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.51723337
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51511395
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50568421
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.46994892
52ZNF263_19887448_ChIP-Seq_K562_Human1.46774889
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.46034995
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45325623
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44389867
56CJUN_26792858_Chip-Seq_BT549_Human1.44290019
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.43383198
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39607231
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39565216
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37175010
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37175010
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36561069
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35122233
64SMC4_20622854_ChIP-Seq_HELA_Human1.35002199
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33644742
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31978639
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31815764
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31504111
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31471107
70AR_21572438_ChIP-Seq_LNCaP_Human1.30609617
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29270479
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.27341076
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26746487
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26562225
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26498426
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.25364910
77VDR_24787735_ChIP-Seq_THP-1_Human1.21097237
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.19485776
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18497687
80PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17052051
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16849598
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16658436
83TP53_18474530_ChIP-ChIP_U2OS_Human1.16470131
84RXR_22108803_ChIP-Seq_LS180_Human1.14638248
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.14428238
86MYC_22102868_ChIP-Seq_BL_Human1.14349935
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12335447
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11175137
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.08024124
90TP63_22573176_ChIP-Seq_HFKS_Human1.07849495
91SCL_19346495_ChIP-Seq_HPC-7_Human1.07103549
92CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06144890
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05939557
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.05929270
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.04759305
96OCT1_27270436_Chip-Seq_PROSTATE_Human1.04355147
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04174022
98GATA6_25053715_ChIP-Seq_YYC3_Human1.04021567
99TP63_23658742_ChIP-Seq_EP156T_Human1.03740619
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03587662
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02390965
102RNF2_27304074_Chip-Seq_ESCs_Mouse1.02364602
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.02031309
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01794546
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00593914
106KDM2B_26808549_Chip-Seq_K562_Human0.99654517
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.98964689
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98900148
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98226276
110BP1_19119308_ChIP-ChIP_Hs578T_Human0.97819664
111GATA1_19941826_ChIP-Seq_K562_Human0.97286605
112NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96407963
113VDR_21846776_ChIP-Seq_THP-1_Human0.95509698
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.95389644
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95332849
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95025373
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.93578352
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.93578352
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.93562925
120SOX2_20726797_ChIP-Seq_SW620_Human0.93484003
121* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93144227
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.92877069
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92685908
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.92461169
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91588665
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90834923
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90726015
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.90689596
129KDM2B_26808549_Chip-Seq_DND41_Human0.90268594
130* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90243173
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90192058
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90192058
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90145177
134VDR_24763502_ChIP-Seq_THP-1_Human0.89824085
135TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87888312
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87534340
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.87036122
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.86844342
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.86304064
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.86014583
141AHR_22903824_ChIP-Seq_MCF-7_Human0.85993508
142KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85796982
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.85379178
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84608817
145GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83884016
146AR_21909140_ChIP-Seq_LNCAP_Human0.83579060
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83562808
148KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83361514
149EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83277162
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82606308
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82461194
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81668776
153FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81578859
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80783670
155EWS_26573619_Chip-Seq_HEK293_Human0.80440387
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.80430531
157KLF5_25053715_ChIP-Seq_YYC3_Human0.78608676
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.78566493
159P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78112669
160SOX2_21211035_ChIP-Seq_LN229_Gbm0.77921845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.38079701
2MP0003935_abnormal_craniofacial_develop4.84947147
3MP0005275_abnormal_skin_tensile4.80651893
4MP0001849_ear_inflammation4.70306305
5MP0005310_abnormal_salivary_gland4.54832498
6MP0005670_abnormal_white_adipose4.43476933
7MP0002166_altered_tumor_susceptibility4.38372136
8MP0002653_abnormal_ependyma_morphology4.28381457
9* MP0000432_abnormal_head_morphology4.11358420
10MP0004272_abnormal_basement_membrane3.51707423
11MP0002822_catalepsy3.40729949
12MP0002877_abnormal_melanocyte_morpholog3.08240908
13MP0005187_abnormal_penis_morphology3.02543156
14MP0004043_abnormal_pH_regulation3.00254824
15MP0002006_tumorigenesis2.99991769
16MP0003315_abnormal_perineum_morphology2.94490914
17MP0008438_abnormal_cutaneous_collagen2.92952967
18MP0002254_reproductive_system_inflammat2.89753398
19MP0005647_abnormal_sex_gland2.81438123
20MP0001542_abnormal_bone_strength2.76419648
21MP0000613_abnormal_salivary_gland2.75953224
22MP0002060_abnormal_skin_morphology2.70939458
23MP0000762_abnormal_tongue_morphology2.68892664
24MP0008961_abnormal_basal_metabolism2.60325134
25MP0000462_abnormal_digestive_system2.59834518
26MP0001873_stomach_inflammation2.58835570
27MP0000537_abnormal_urethra_morphology2.54859283
28MP0003011_delayed_dark_adaptation2.53397123
29MP0004510_myositis2.53012604
30MP0003045_fibrosis2.16960541
31MP0004145_abnormal_muscle_electrophysio2.16078206
32MP0005167_abnormal_blood-brain_barrier2.09870766
33MP0000538_abnormal_urinary_bladder2.09535289
34MP0003300_gastrointestinal_ulcer2.06577276
35MP0002896_abnormal_bone_mineralization1.94377859
36MP0003941_abnormal_skin_development1.87819507
37MP0005666_abnormal_adipose_tissue1.85872107
38MP0009250_abnormal_appendicular_skeleto1.83338465
39MP0003879_abnormal_hair_cell1.82943018
40MP0001299_abnormal_eye_distance/1.82383056
41MP0005451_abnormal_body_composition1.81349369
42MP0002116_abnormal_craniofacial_bone1.80770147
43MP0002735_abnormal_chemical_nociception1.77822047
44MP0001765_abnormal_ion_homeostasis1.76591004
45MP0004947_skin_inflammation1.76512780
46MP0001756_abnormal_urination1.75386718
47MP0005645_abnormal_hypothalamus_physiol1.71082292
48MP0004036_abnormal_muscle_relaxation1.69295731
49MP0010030_abnormal_orbit_morphology1.67193803
50MP0005220_abnormal_exocrine_pancreas1.63912202
51MP0005646_abnormal_pituitary_gland1.59719724
52MP0010386_abnormal_urinary_bladder1.57245326
53MP0005076_abnormal_cell_differentiation1.53433516
54MP0002909_abnormal_adrenal_gland1.50122533
55MP0003705_abnormal_hypodermis_morpholog1.48765540
56MP0002098_abnormal_vibrissa_morphology1.47948803
57MP0003566_abnormal_cell_adhesion1.44561479
58MP0000383_abnormal_hair_follicle1.42542019
59MP0000733_abnormal_muscle_development1.42032678
60MP0010234_abnormal_vibrissa_follicle1.41846616
61MP0002736_abnormal_nociception_after1.41123894
62MP0005410_abnormal_fertilization1.40155510
63MP0000163_abnormal_cartilage_morphology1.39609608
64MP0010678_abnormal_skin_adnexa1.35530804
65MP0000467_abnormal_esophagus_morphology1.32514337
66MP0004264_abnormal_extraembryonic_tissu1.31980895
67MP0001216_abnormal_epidermal_layer1.31654909
68MP0006054_spinal_hemorrhage1.28921544
69MP0010771_integument_phenotype1.27129325
70MP0005023_abnormal_wound_healing1.26926603
71MP0000534_abnormal_ureter_morphology1.25926881
72MP0001501_abnormal_sleep_pattern1.24707706
73MP0005375_adipose_tissue_phenotype1.21360235
74MP0000516_abnormal_urinary_system1.20406437
75MP0005367_renal/urinary_system_phenotyp1.20406437
76MP0002009_preneoplasia1.20187811
77MP0000230_abnormal_systemic_arterial1.19814167
78MP0000604_amyloidosis1.18921089
79MP0003646_muscle_fatigue1.18713922
80MP0003385_abnormal_body_wall1.18307638
81MP0000049_abnormal_middle_ear1.16528545
82MP0005085_abnormal_gallbladder_physiolo1.15484935
83MP0009931_abnormal_skin_appearance1.14956365
84MP0000647_abnormal_sebaceous_gland1.11644493
85MP0001666_abnormal_nutrient_absorption1.11568075
86MP0002796_impaired_skin_barrier1.11530481
87MP0003868_abnormal_feces_composition1.08556461
88MP0002998_abnormal_bone_remodeling1.07550792
89MP0003755_abnormal_palate_morphology1.05796250
90MP0004885_abnormal_endolymph1.04764349
91MP0002249_abnormal_larynx_morphology1.04460509
92MP0000428_abnormal_craniofacial_morphol1.04433560
93MP0003866_abnormal_defecation1.03663075
94MP0005623_abnormal_meninges_morphology1.03275577
95MP0001968_abnormal_touch/_nociception1.02372435
96MP0002168_other_aberrant_phenotype1.02071508
97MP0001270_distended_abdomen1.01122049
98MP0000678_abnormal_parathyroid_gland1.00399714
99MP0004233_abnormal_muscle_weight0.97321569
100MP0002295_abnormal_pulmonary_circulatio0.97260390
101MP0003329_amyloid_beta_deposits0.96524882
102MP0005508_abnormal_skeleton_morphology0.95806296
103MP0002115_abnormal_skeleton_extremities0.94970048
104MP0009384_cardiac_valve_regurgitation0.94320825
105MP0001346_abnormal_lacrimal_gland0.93722044
106MP0005409_darkened_coat_color0.93361367
107MP0004185_abnormal_adipocyte_glucose0.93206613
108MP0000579_abnormal_nail_morphology0.93005009
109MP0005503_abnormal_tendon_morphology0.92365671
110MP0009053_abnormal_anal_canal0.92053740
111MP0003091_abnormal_cell_migration0.89952595
112MP0001915_intracranial_hemorrhage0.88784461
113MP0001958_emphysema0.84777602
114MP0004859_abnormal_synaptic_plasticity0.84752988
115MP0002282_abnormal_trachea_morphology0.83093295
116MP0002876_abnormal_thyroid_physiology0.82801966
117MP0002177_abnormal_outer_ear0.82178286
118MP0002109_abnormal_limb_morphology0.82056975
119MP0002233_abnormal_nose_morphology0.81636373
120MP0003279_aneurysm0.81523646
121MP0003795_abnormal_bone_structure0.80485587
122MP0002638_abnormal_pupillary_reflex0.77836112
123MP0005248_abnormal_Harderian_gland0.76708575
124MP0000627_abnormal_mammary_gland0.75799314
125MP0005381_digestive/alimentary_phenotyp0.73016187
126MP0005330_cardiomyopathy0.72665342
127MP0001348_abnormal_lacrimal_gland0.72201126
128MP0005636_abnormal_mineral_homeostasis0.72007250
129MP0002693_abnormal_pancreas_physiology0.71532599
130MP0000470_abnormal_stomach_morphology0.71257301
131MP0000377_abnormal_hair_follicle0.71028617
132MP0002113_abnormal_skeleton_development0.70853623
133MP0009780_abnormal_chondrocyte_physiolo0.68262866
134MP0003787_abnormal_imprinting0.68044174
135MP0005395_other_phenotype0.67923846
136MP0004858_abnormal_nervous_system0.67892505
137MP0002108_abnormal_muscle_morphology0.67489815
138MP0003953_abnormal_hormone_level0.67379963
139MP0002557_abnormal_social/conspecific_i0.67240364
140MP0003698_abnormal_male_reproductive0.65690819
141MP0005448_abnormal_energy_balance0.65331611
142MP0002078_abnormal_glucose_homeostasis0.64601366
143MP0003448_altered_tumor_morphology0.64293796
144MP0003937_abnormal_limbs/digits/tail_de0.64278232
145MP0006138_congestive_heart_failure0.63540555
146MP0005166_decreased_susceptibility_to0.63351454
147MP0002090_abnormal_vision0.62706680
148MP0001340_abnormal_eyelid_morphology0.61549635
149MP0003453_abnormal_keratinocyte_physiol0.60918079
150MP0003942_abnormal_urinary_system0.59620181
151MP0005319_abnormal_enzyme/_coenzyme0.58657300
152MP0000371_diluted_coat_color0.58462290
153MP0001764_abnormal_homeostasis0.58005734
154MP0000566_synostosis0.55696466
155MP0009115_abnormal_fat_cell0.55657181
156MP0001919_abnormal_reproductive_system0.55222428
157MP0001243_abnormal_dermal_layer0.54326599
158MP0002933_joint_inflammation0.54180008
159MP0003283_abnormal_digestive_organ0.54018839
160MP0005620_abnormal_muscle_contractility0.52970664
161MP0004270_analgesia0.52099439
162* MP0001731_abnormal_postnatal_growth0.51046197
163MP0002136_abnormal_kidney_physiology0.50698000
164MP0002697_abnormal_eye_size0.46458456
165MP0004484_altered_response_of0.46236130
166MP0000343_altered_response_to0.45925333
167MP0005390_skeleton_phenotype0.45727367
168MP0001664_abnormal_digestion0.45514993
169MP0002932_abnormal_joint_morphology0.43294458
170MP0001533_abnormal_skeleton_physiology0.42210520
171MP0004084_abnormal_cardiac_muscle0.41884683
172MP0005197_abnormal_uvea_morphology0.40871158
173MP0005193_abnormal_anterior_eye0.39997479

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)9.20729414
2Milia (HP:0001056)8.43682976
3Fragile nails (HP:0001808)8.37296273
4Aortic aneurysm (HP:0004942)5.45726197
5Abnormality of dental color (HP:0011073)5.42226020
6Neoplasm of the heart (HP:0100544)4.70963578
7Abnormality of secondary sexual hair (HP:0009888)4.66914743
8Abnormality of the axillary hair (HP:0100134)4.66914743
9Obstructive sleep apnea (HP:0002870)4.49670994
10Broad face (HP:0000283)4.40741672
11Plantar hyperkeratosis (HP:0007556)4.36891690
12Sparse lateral eyebrow (HP:0005338)4.34473272
13Hypoplasia of dental enamel (HP:0006297)3.98291549
14Flat acetabular roof (HP:0003180)3.83335767
15Abnormality of the distal phalanx of the thumb (HP:0009617)3.78464418
16Genetic anticipation (HP:0003743)3.69386027
17Malnutrition (HP:0004395)3.64688225
18Dysmetric saccades (HP:0000641)3.62705895
19Short 1st metacarpal (HP:0010034)3.47876331
20Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.47876331
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.47051399
22Abnormality of the 1st metacarpal (HP:0010009)3.43239962
23Abnormality of the fingertips (HP:0001211)3.41344296
24Intrahepatic cholestasis (HP:0001406)3.34399300
25Metaphyseal cupping (HP:0003021)3.26253275
26Aortic regurgitation (HP:0001659)3.20080787
27Short phalanx of the thumb (HP:0009660)3.15383844
28Abnormal tarsal ossification (HP:0008369)3.12506734
29Advanced eruption of teeth (HP:0006288)3.12443455
30Abnormality of the phalanges of the hallux (HP:0010057)3.12399562
31Laryngomalacia (HP:0001601)3.11222922
32* Amelogenesis imperfecta (HP:0000705)27.9184009
33Nail dystrophy (HP:0008404)2.97523098
34Overgrowth (HP:0001548)2.80586726
35Germ cell neoplasia (HP:0100728)2.77867275
36Persistence of primary teeth (HP:0006335)2.73253981
37Widely patent fontanelles and sutures (HP:0004492)2.72570416
38Abnormal ossification of hand bones (HP:0005921)2.69280817
39Anal stenosis (HP:0002025)2.68411779
40Testicular atrophy (HP:0000029)2.66465948
41Abnormality of carpal bone ossification (HP:0006257)2.66261841
42Neonatal hypoglycemia (HP:0001998)2.66132627
43Bundle branch block (HP:0011710)2.59343422
44Abnormal hand bone ossification (HP:0010660)2.58598951
45Lip pit (HP:0100267)2.56971973
46Abnormal foot bone ossification (HP:0010675)2.53256916
47Tracheomalacia (HP:0002779)2.52879685
48Hypoplastic nipples (HP:0002557)2.51407638
49Prostate neoplasm (HP:0100787)2.40426269
50Hypodontia (HP:0000668)2.39406538
51Abnormality of abdominal situs (HP:0011620)2.38183600
52Abdominal situs inversus (HP:0003363)2.38183600
53Aplasia of the musculature (HP:0100854)2.37835064
54Calf muscle hypertrophy (HP:0008981)2.37639524
55Myokymia (HP:0002411)2.36347054
56Death in infancy (HP:0001522)2.35169209
57Abnormality of the distal phalanges of the toes (HP:0010182)2.32802729
58Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.32716596
59Flattened epiphyses (HP:0003071)2.32288648
60Urethral obstruction (HP:0000796)2.31624830
61Prolonged QT interval (HP:0001657)2.31544752
62Broad metatarsal (HP:0001783)2.31310870
63Depressed nasal tip (HP:0000437)2.27252149
64Clumsiness (HP:0002312)2.27219566
65Abnormality of the parathyroid morphology (HP:0011766)2.25736343
66Aplasia/hypoplasia of the femur (HP:0005613)2.24645760
67Gaze-evoked nystagmus (HP:0000640)2.24078019
68Abnormality of the proximal phalanges of the hand (HP:0009834)2.23715714
69Cervical subluxation (HP:0003308)2.21738295
70Premature loss of primary teeth (HP:0006323)2.20255666
71Aneurysm (HP:0002617)2.20003153
72Gonadotropin excess (HP:0000837)2.17578114
73Natal tooth (HP:0000695)2.17149661
74Hyperventilation (HP:0002883)2.16238902
75Short middle phalanx of the 5th finger (HP:0004220)2.16095610
76Supernumerary ribs (HP:0005815)2.13004872
77Gastrointestinal dysmotility (HP:0002579)2.12627244
78Stroke (HP:0001297)2.11263535
79Aplasia/Hypoplasia of the tibia (HP:0005772)2.08911058
80Abnormality of the nasal septum (HP:0000419)2.08109545
81Ureteral stenosis (HP:0000071)2.06764207
82Short nail (HP:0001799)2.06580881
83Progressive cerebellar ataxia (HP:0002073)2.05947679
84Muscle hypertrophy of the lower extremities (HP:0008968)2.05855251
85Segmental peripheral demyelination/remyelination (HP:0003481)2.05123248
86Hypoplasia of the odontoid process (HP:0003311)2.05018822
87Osteomalacia (HP:0002749)2.05000120
88Breast hypoplasia (HP:0003187)2.04427960
89Protrusio acetabuli (HP:0003179)2.02800819
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00603634
91Impaired smooth pursuit (HP:0007772)2.00283341
92Onycholysis (HP:0001806)13.4097534
93Weak cry (HP:0001612)1.98195284
94Supernumerary bones of the axial skeleton (HP:0009144)1.97942460
95Split foot (HP:0001839)1.96433938
96Long eyelashes (HP:0000527)1.96324008
97Precocious puberty (HP:0000826)1.96303960
98Tented upper lip vermilion (HP:0010804)1.95815007
99Asymmetric septal hypertrophy (HP:0001670)1.94889902
100Ureteral obstruction (HP:0006000)1.94860584
101Generalized hypopigmentation of hair (HP:0011358)1.91690190
102Wide cranial sutures (HP:0010537)1.90433346
103Parakeratosis (HP:0001036)1.90100073
104Septate vagina (HP:0001153)1.89672134
105Abnormality of the odontoid process (HP:0003310)1.86035776
106Midface retrusion (HP:0011800)1.85232070
107Shallow orbits (HP:0000586)1.85124831
108Abnormality of the ischium (HP:0003174)1.85117630
109Hyperkalemia (HP:0002153)1.84178137
110Premature rupture of membranes (HP:0001788)1.83542167
111Abnormality of the frontal sinuses (HP:0002687)1.82323231
112Protruding tongue (HP:0010808)1.81838467
113Shawl scrotum (HP:0000049)1.81482409
114Short humerus (HP:0005792)1.80841857
115Turricephaly (HP:0000262)1.79866551
116Abnormal blistering of the skin (HP:0008066)1.76647997
117Abnormality of the aortic arch (HP:0012303)1.75273667
118Spondylolisthesis (HP:0003302)1.74196127
119Sandal gap (HP:0001852)1.73727770
120Absent frontal sinuses (HP:0002688)1.73523532
121Ulnar bowing (HP:0003031)1.72255890
122Congenital glaucoma (HP:0001087)1.71773093
123Patellar dislocation (HP:0002999)1.70599208
124Pyloric stenosis (HP:0002021)1.70391006
125Prolonged neonatal jaundice (HP:0006579)1.70323914
126Renal tubular acidosis (HP:0001947)1.70306857
127Azoospermia (HP:0000027)1.69847816
128Anosmia (HP:0000458)1.68518207
129Right ventricular cardiomyopathy (HP:0011663)1.68378382
130Microdontia (HP:0000691)1.67934868
131Carious teeth (HP:0000670)1.67710748
132Dehydration (HP:0001944)1.65473577
133Abnormality of the costochondral junction (HP:0000919)1.65377769
134Abnormality of the parietal bone (HP:0002696)1.65208423
135Fragile skin (HP:0001030)1.64121715
136Hoarse voice (HP:0001609)1.60486648
137Dental malocclusion (HP:0000689)1.59057094
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.52470658
139Blue sclerae (HP:0000592)1.47852586
140Coronal craniosynostosis (HP:0004440)1.47422925
141Bronchomalacia (HP:0002780)1.46826903
142Aplasia cutis congenita (HP:0001057)1.46778937
143Osteolytic defects of the hand bones (HP:0009699)1.44366786
144Osteolytic defects of the phalanges of the hand (HP:0009771)1.44366786
145Aortic dissection (HP:0002647)1.43786400
146Oligodontia (HP:0000677)1.42948950
147Vertebral clefting (HP:0008428)1.41908928
148Wormian bones (HP:0002645)1.41696581
149Decreased skull ossification (HP:0004331)1.39260891
150Enlarged penis (HP:0000040)1.39089363
151Oligodactyly (hands) (HP:0001180)1.37435852
152Hypotrichosis (HP:0001006)1.37273617
153Multiple enchondromatosis (HP:0005701)1.31990041
154Abnormality of primary teeth (HP:0006481)1.31893578
155Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.26815225
156Heterogeneous (HP:0001425)1.26356570
157Autoimmune thrombocytopenia (HP:0001973)1.25910424
158Cerebral aneurysm (HP:0004944)1.24252556
159X-linked dominant inheritance (HP:0001423)1.24060985
160Irregular vertebral endplates (HP:0003301)1.22893198
161Abnormality of skull ossification (HP:0002703)1.17453296
162Short hallux (HP:0010109)1.16541210
163Spinal cord lesions (HP:0100561)1.16388245
164Syringomyelia (HP:0003396)1.16388245
165Abnormality of dentin (HP:0010299)1.15024066
166Epileptic encephalopathy (HP:0200134)1.14612687
167Small epiphyses (HP:0010585)1.14597279
168Abnormal vertebral ossification (HP:0100569)1.14386306
169Humeroradial synostosis (HP:0003041)1.13186892
170Synostosis involving the elbow (HP:0003938)1.13186892
171Ridged nail (HP:0001807)1.12977895
172Alopecia of scalp (HP:0002293)1.12309629
173Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.11724454
174Absent eyebrow (HP:0002223)1.11573262
175Hyperhidrosis (HP:0000975)1.10730570
176Mitral valve prolapse (HP:0001634)1.10342765
177Bowed forearm bones (HP:0003956)1.09135926
178Bowing of the arm (HP:0006488)1.09135926
179Short middle phalanx of finger (HP:0005819)1.06996630
180Narrow nasal bridge (HP:0000446)1.06323037
181Aplasia/Hypoplasia of the hallux (HP:0008362)1.04319286
182Choanal stenosis (HP:0000452)1.03829849
183Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.03780135
184Short 5th finger (HP:0009237)1.03571276
185Arterial tortuosity (HP:0005116)1.01810776
186Abnormality of the fingernails (HP:0001231)1.00635903
187Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.00021515
188Camptodactyly of finger (HP:0100490)0.98659951
189Striae distensae (HP:0001065)0.98546621
190Deviation of the hallux (HP:0010051)0.97971879
191Radial bowing (HP:0002986)0.96195982
192Bladder diverticulum (HP:0000015)0.96032976
193Aqueductal stenosis (HP:0002410)0.95365836
194Skin ulcer (HP:0200042)0.95247865
195Selective tooth agenesis (HP:0001592)0.95044410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.83037970
2CAMK1D6.67745861
3MAP3K36.37558072
4CAMK1G5.25971756
5TRPM74.66229987
6CDK63.70548895
7EEF2K3.61770202
8MYLK2.86953096
9TNK22.74335229
10FGFR22.62975253
11BMX2.56793802
12TAOK12.56576757
13CAMK42.32074194
14TRIB32.27237611
15CSNK1A12.13542206
16CDK122.09191611
17RIPK12.02299292
18MARK22.00635251
19PDGFRA2.00560398
20DYRK1A1.91243871
21DMPK1.87037493
22CAMK11.78581418
23WNK41.78429303
24ICK1.78076361
25FRK1.72711696
26CDK91.70872412
27LRRK21.68183050
28FGFR11.57586972
29LMTK21.56532481
30PRKD21.50872528
31DDR21.50459418
32TGFBR21.47594018
33PAK41.45807688
34EPHB11.44284352
35DYRK1B1.43822209
36PIM21.42225845
37SMG11.40373310
38NTRK11.38292446
39MTOR1.36786941
40FER1.35799559
41SGK4941.23995682
42SGK2231.23995682
43MAPKAPK31.21050887
44PRKAA21.14060870
45PTK61.13904486
46PTK21.13177804
47STK381.12579631
48RET1.12169655
49PRKD11.11753852
50PKN21.11014401
51MAPK41.10417795
52MAPK151.09717558
53STK391.09405500
54BRD41.08957395
55LATS11.08676463
56PAK21.06298907
57MAP3K71.05661103
58EPHA31.05641372
59TTN1.05106776
60SCYL21.05025474
61SGK21.04651418
62HIPK21.04531787
63PAK31.04103066
64WNK11.02521973
65GSK3A0.95218871
66NTRK30.94706605
67FGFR40.94294487
68PAK60.93202905
69EPHA40.90137916
70PRKCE0.88858129
71PRKD30.84951796
72PRKAA10.82363703
73MAPK120.81473978
74CDC42BPA0.81335251
75BCR0.81020832
76ACVR1B0.78690552
77SGK30.78175049
78PDK20.77165163
79TESK10.76909840
80KSR20.75220727
81FGFR30.74290859
82EPHB20.74282413
83PRKCZ0.72939875
84CSNK1A1L0.72430299
85RPS6KA20.71926272
86TAOK30.71202807
87MAP3K20.69885246
88ERN10.69742826
89ERBB30.69683903
90MINK10.66958396
91DAPK20.66079891
92TYRO30.65651633
93PDGFRB0.65182379
94LATS20.63639692
95FGR0.62454433
96CHUK0.62183788
97CDK40.61553209
98NLK0.61165494
99IRAK30.60888118
100ROCK20.59384960
101UHMK10.58255167
102CDK140.57551694
103SIK10.57162663
104CDK50.56201170
105CAMK2A0.55292860
106CAMKK10.54906142
107PRKCH0.54765341
108STK38L0.54279644
109MAPK70.53959827
110DAPK30.53845079
111SRC0.53304470
112PIK3CA0.53090754
113EPHA20.52942533
114KSR10.51248944
115CDK190.50583869
116ALK0.47190816
117CDK150.47002600
118CDK180.44975314
119FYN0.44737669
120IGF1R0.44443022
121ROCK10.43617165
122RIPK40.42957913
123PRKCI0.42957625
124MAP3K100.42615423
125PDPK10.41747969
126MAP3K130.41420333
127PTK2B0.40551620
128MET0.40358662
129EGFR0.39999499
130IRAK20.39531397
131CDK11A0.39115324
132PLK20.38618183
133CSNK1G30.38254154
134CSNK1G10.38040533
135CSNK1G20.37458829
136ERBB20.37186825
137MAPK80.36942746
138SGK10.36009422
139TESK20.35876367
140PDK10.33467499
141STK100.33123960
142MAPK10.32128585
143IRAK10.29765934
144MAP2K20.29750349
145MATK0.29673398
146NEK90.29658575
147GSK3B0.29220248
148ABL10.28424911
149AKT10.26969174
150RPS6KA60.24570034
151RPS6KA10.22717688
152ILK0.22194557
153MAP2K60.22075494
154RPS6KA50.21866671
155CDK70.21812055
156RPS6KC10.21222868
157RPS6KL10.21222868
158BRAF0.20503225
159INSRR0.19826971
160ARAF0.19242119
161MAPK140.18085218
162NEK60.15951930
163RPS6KA30.15570165

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.40940630
2ECM-receptor interaction_Homo sapiens_hsa045125.61258478
3Amoebiasis_Homo sapiens_hsa051463.14433478
4Small cell lung cancer_Homo sapiens_hsa052222.93810895
5Folate biosynthesis_Homo sapiens_hsa007902.78139987
6Renin-angiotensin system_Homo sapiens_hsa046142.63648715
7Focal adhesion_Homo sapiens_hsa045102.41767850
8Toxoplasmosis_Homo sapiens_hsa051452.33610944
9Vascular smooth muscle contraction_Homo sapiens_hsa042702.20670489
10Histidine metabolism_Homo sapiens_hsa003402.17795868
11Fatty acid metabolism_Homo sapiens_hsa012122.00744098
12Lysine degradation_Homo sapiens_hsa003101.97121585
13Basal cell carcinoma_Homo sapiens_hsa052171.93786104
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91073607
15Phenylalanine metabolism_Homo sapiens_hsa003601.87315058
16Hedgehog signaling pathway_Homo sapiens_hsa043401.72902448
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.67816446
18beta-Alanine metabolism_Homo sapiens_hsa004101.67540374
19Nitrogen metabolism_Homo sapiens_hsa009101.64951787
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58868670
21Proteoglycans in cancer_Homo sapiens_hsa052051.58181713
22Fructose and mannose metabolism_Homo sapiens_hsa000511.55900712
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51476573
24AMPK signaling pathway_Homo sapiens_hsa041521.47354639
25Arachidonic acid metabolism_Homo sapiens_hsa005901.47251173
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.47196210
27mTOR signaling pathway_Homo sapiens_hsa041501.44233991
28Gastric acid secretion_Homo sapiens_hsa049711.41027496
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.40063690
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.38388641
31GnRH signaling pathway_Homo sapiens_hsa049121.36446162
32Hippo signaling pathway_Homo sapiens_hsa043901.33584326
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32170220
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29116823
35Insulin resistance_Homo sapiens_hsa049311.27983784
36Wnt signaling pathway_Homo sapiens_hsa043101.27375423
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.26305173
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25385031
39Adherens junction_Homo sapiens_hsa045201.23827398
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22499595
41Bile secretion_Homo sapiens_hsa049761.20506179
42Vitamin digestion and absorption_Homo sapiens_hsa049771.16581014
43Pathways in cancer_Homo sapiens_hsa052001.16065331
44Melanogenesis_Homo sapiens_hsa049161.15184426
45Arginine and proline metabolism_Homo sapiens_hsa003301.14919935
46Salivary secretion_Homo sapiens_hsa049701.14296088
47Ovarian steroidogenesis_Homo sapiens_hsa049131.12478970
48Acute myeloid leukemia_Homo sapiens_hsa052211.11660706
49ABC transporters_Homo sapiens_hsa020101.11538337
50Propanoate metabolism_Homo sapiens_hsa006401.09421345
51Caffeine metabolism_Homo sapiens_hsa002321.07655874
52TGF-beta signaling pathway_Homo sapiens_hsa043501.06922916
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05893896
54Bladder cancer_Homo sapiens_hsa052191.05061547
55Mineral absorption_Homo sapiens_hsa049781.03256974
56Insulin signaling pathway_Homo sapiens_hsa049101.03211519
57MicroRNAs in cancer_Homo sapiens_hsa052061.00770092
58Vibrio cholerae infection_Homo sapiens_hsa051101.00391603
59Dilated cardiomyopathy_Homo sapiens_hsa054140.98823122
60Glioma_Homo sapiens_hsa052140.98752875
61Long-term depression_Homo sapiens_hsa047300.97002042
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.96435819
63Circadian rhythm_Homo sapiens_hsa047100.95708906
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95049391
65Tight junction_Homo sapiens_hsa045300.94562615
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93816003
67Collecting duct acid secretion_Homo sapiens_hsa049660.92971794
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90998055
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.89247225
70Choline metabolism in cancer_Homo sapiens_hsa052310.88362631
71Long-term potentiation_Homo sapiens_hsa047200.88316166
72Chronic myeloid leukemia_Homo sapiens_hsa052200.87171802
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86990319
74Thyroid hormone synthesis_Homo sapiens_hsa049180.86924151
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86360834
76Protein digestion and absorption_Homo sapiens_hsa049740.86106305
77Synaptic vesicle cycle_Homo sapiens_hsa047210.86027276
78Circadian entrainment_Homo sapiens_hsa047130.84734870
79Type II diabetes mellitus_Homo sapiens_hsa049300.84612164
80Fatty acid degradation_Homo sapiens_hsa000710.84532353
81Melanoma_Homo sapiens_hsa052180.83398381
82FoxO signaling pathway_Homo sapiens_hsa040680.83297312
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79355775
84Cocaine addiction_Homo sapiens_hsa050300.78721291
85Pancreatic secretion_Homo sapiens_hsa049720.78236081
86Complement and coagulation cascades_Homo sapiens_hsa046100.78186486
87Olfactory transduction_Homo sapiens_hsa047400.78141578
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77349116
89Gap junction_Homo sapiens_hsa045400.77087197
90PPAR signaling pathway_Homo sapiens_hsa033200.75104619
91Axon guidance_Homo sapiens_hsa043600.74258007
92Notch signaling pathway_Homo sapiens_hsa043300.74187301
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74102920
94Platelet activation_Homo sapiens_hsa046110.73942166
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.71932184
96Rheumatoid arthritis_Homo sapiens_hsa053230.71542543
97Cholinergic synapse_Homo sapiens_hsa047250.70071085
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69273847
99Tyrosine metabolism_Homo sapiens_hsa003500.68765924
100Prostate cancer_Homo sapiens_hsa052150.68729809
101Arginine biosynthesis_Homo sapiens_hsa002200.68654376
102Linoleic acid metabolism_Homo sapiens_hsa005910.68402829
103GABAergic synapse_Homo sapiens_hsa047270.66649757
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66529492
105cAMP signaling pathway_Homo sapiens_hsa040240.66331913
106Insulin secretion_Homo sapiens_hsa049110.66216746
107Amphetamine addiction_Homo sapiens_hsa050310.65936817
108Glutamatergic synapse_Homo sapiens_hsa047240.65592292
109Phagosome_Homo sapiens_hsa041450.65547151
110Peroxisome_Homo sapiens_hsa041460.64887691
111Renin secretion_Homo sapiens_hsa049240.63201170
112Pancreatic cancer_Homo sapiens_hsa052120.62418106
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62163307
114Oxytocin signaling pathway_Homo sapiens_hsa049210.61874103
115Estrogen signaling pathway_Homo sapiens_hsa049150.60535676
116Dopaminergic synapse_Homo sapiens_hsa047280.59574775
117Tryptophan metabolism_Homo sapiens_hsa003800.57694292
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57069015
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56868521
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.55746636
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55660787
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.55569085
123Rap1 signaling pathway_Homo sapiens_hsa040150.54794174
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54630128
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54231535
126Pyruvate metabolism_Homo sapiens_hsa006200.51815783
127ErbB signaling pathway_Homo sapiens_hsa040120.51220297
128Dorso-ventral axis formation_Homo sapiens_hsa043200.51090501
129MAPK signaling pathway_Homo sapiens_hsa040100.50756477
130Endometrial cancer_Homo sapiens_hsa052130.50568826
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50358586
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50029881
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47732505
134Non-small cell lung cancer_Homo sapiens_hsa052230.47701533
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.46351873
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44542837
137TNF signaling pathway_Homo sapiens_hsa046680.42200198
138Sulfur metabolism_Homo sapiens_hsa009200.40361735
139Lysosome_Homo sapiens_hsa041420.40173723
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.39459986
141Renal cell carcinoma_Homo sapiens_hsa052110.39379788
142Glucagon signaling pathway_Homo sapiens_hsa049220.39139890
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38629961
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37779679
145Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37019404
146Butanoate metabolism_Homo sapiens_hsa006500.35143337
147Malaria_Homo sapiens_hsa051440.35041082
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34587028
149Serotonergic synapse_Homo sapiens_hsa047260.34556984
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33658454
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32829795
152VEGF signaling pathway_Homo sapiens_hsa043700.32616051
153Calcium signaling pathway_Homo sapiens_hsa040200.32369909

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