KLK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.97116921
2hair cycle (GO:0042633)9.13537183
3molting cycle (GO:0042303)9.13537183
4keratinocyte differentiation (GO:0030216)8.85970482
5water homeostasis (GO:0030104)8.33718001
6long-chain fatty acid biosynthetic process (GO:0042759)7.78390681
7peptide cross-linking (GO:0018149)7.57809436
8epidermal cell differentiation (GO:0009913)6.97399745
9keratinocyte proliferation (GO:0043616)6.87518808
10hemidesmosome assembly (GO:0031581)6.78930657
11cell-substrate junction assembly (GO:0007044)6.75914129
12intermediate filament organization (GO:0045109)6.61739692
13bundle of His cell to Purkinje myocyte communication (GO:0086069)6.44926997
14sphingoid metabolic process (GO:0046519)6.19168552
15skin morphogenesis (GO:0043589)5.77040960
16* epidermis development (GO:0008544)5.73663667
17regulation of ruffle assembly (GO:1900027)5.72436284
18linoleic acid metabolic process (GO:0043651)5.65275421
19detection of bacterium (GO:0016045)5.50939954
20fatty acid elongation (GO:0030497)5.48967274
21regulation of keratinocyte proliferation (GO:0010837)5.44681844
22sphingosine metabolic process (GO:0006670)5.38752718
23glucosamine-containing compound catabolic process (GO:1901072)5.36983554
24positive regulation of epidermal cell differentiation (GO:0045606)5.16042815
25regulation of transforming growth factor beta1 production (GO:0032908)5.08537332
26diol metabolic process (GO:0034311)4.87364870
27lipoxygenase pathway (GO:0019372)4.84763938
28regulation of cell proliferation involved in kidney development (GO:1901722)4.78895324
29gap junction assembly (GO:0016264)4.73526537
30detection of other organism (GO:0098543)4.65720186
31positive regulation of glomerulus development (GO:0090193)4.59929273
32ectoderm development (GO:0007398)4.57650030
33regulation of phospholipase A2 activity (GO:0032429)4.43860046
34polarized epithelial cell differentiation (GO:0030859)4.39368506
35intermediate filament cytoskeleton organization (GO:0045104)4.32768992
36intermediate filament-based process (GO:0045103)4.22120215
37positive regulation of interleukin-8 secretion (GO:2000484)4.15103578
38regulation of transforming growth factor beta2 production (GO:0032909)4.13303231
39keratinocyte development (GO:0003334)4.00535646
40positive regulation of keratinocyte differentiation (GO:0045618)3.94571198
41regulation of epidermis development (GO:0045682)3.89719970
42phospholipid scrambling (GO:0017121)3.87849012
43chemical homeostasis within a tissue (GO:0048875)3.87685564
44cell adhesion mediated by integrin (GO:0033627)3.84631329
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.82268222
46epithelial cell differentiation involved in prostate gland development (GO:0060742)3.79880217
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.69599293
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.66145508
49negative regulation of stress fiber assembly (GO:0051497)3.64034653
50amyloid precursor protein metabolic process (GO:0042982)3.59945157
51cyclooxygenase pathway (GO:0019371)3.55468635
52regulation of hypersensitivity (GO:0002883)3.55243987
53surfactant homeostasis (GO:0043129)3.54741806
54positive regulation of hair cycle (GO:0042635)3.35889554
55positive regulation of hair follicle development (GO:0051798)3.35889554
56regulation of natural killer cell differentiation (GO:0032823)3.34702326
57protein autoprocessing (GO:0016540)3.32630338
58regulation of keratinocyte differentiation (GO:0045616)3.31879955
59phosphatidylserine acyl-chain remodeling (GO:0036150)3.28190748
60lateral sprouting from an epithelium (GO:0060601)3.26027939
61negative regulation of keratinocyte proliferation (GO:0010839)3.20919955
62establishment of planar polarity (GO:0001736)3.20679700
63establishment of tissue polarity (GO:0007164)3.20679700
64negative regulation of epidermis development (GO:0045683)3.18966259
65ventricular cardiac muscle cell action potential (GO:0086005)3.18824396
66mesodermal cell differentiation (GO:0048333)3.18095658
67positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.15905745
68negative regulation of chondrocyte differentiation (GO:0032331)3.14549927
69regulation of epidermal cell differentiation (GO:0045604)3.13828489
70adhesion of symbiont to host cell (GO:0044650)3.13520726
71virion attachment to host cell (GO:0019062)3.13520726
72phospholipid efflux (GO:0033700)3.13301391
73negative regulation of interferon-gamma production (GO:0032689)3.11763311
74phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.11243232
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.09857424
76regulation of glomerulus development (GO:0090192)3.06430332
77cell junction assembly (GO:0034329)3.05333559
78eyelid development in camera-type eye (GO:0061029)3.03992410
79gland morphogenesis (GO:0022612)3.02231716
80fatty-acyl-CoA metabolic process (GO:0035337)3.01606938
81regulation of interleukin-8 secretion (GO:2000482)3.00848275
82G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98480209
83skin development (GO:0043588)2.97574685
84L-serine transport (GO:0015825)2.97191613
85hypotonic response (GO:0006971)2.96076926
86regulation of chemokine secretion (GO:0090196)2.94941524
87cell junction organization (GO:0034330)2.94062287
88positive regulation of epidermis development (GO:0045684)2.92882861
89positive regulation of cholesterol efflux (GO:0010875)2.91131239
90interferon-gamma secretion (GO:0072643)2.90671158
91negative regulation of cell fate specification (GO:0009996)2.89019355
92atrioventricular valve morphogenesis (GO:0003181)2.86646986
93protein localization to endosome (GO:0036010)2.86556548
94intestinal epithelial cell development (GO:0060576)2.82874579
95phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.81485754
96regulation of hair follicle development (GO:0051797)2.80088257
97sphingolipid biosynthetic process (GO:0030148)2.79593377
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79502500
99regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.78330455
100endodermal cell differentiation (GO:0035987)2.78114562
101positive regulation of monocyte chemotaxis (GO:0090026)2.75165296
102regulation of transforming growth factor beta production (GO:0071634)2.73643330
103regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.73622614
104phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72645636
105regulation of axon regeneration (GO:0048679)2.70884178
106regulation of neuron projection regeneration (GO:0070570)2.70884178
107primary alcohol catabolic process (GO:0034310)2.70048836
108long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.69873643
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.69724997
110cell communication involved in cardiac conduction (GO:0086065)2.69651875
111hair follicle morphogenesis (GO:0031069)2.69387713
112* epithelium development (GO:0060429)2.68524420
113hair cycle process (GO:0022405)2.62833241
114molting cycle process (GO:0022404)2.62833241
115amino sugar catabolic process (GO:0046348)2.61987563
116morphogenesis of embryonic epithelium (GO:0016331)2.61690339
117focal adhesion assembly (GO:0048041)2.60529223
118cell-substrate adherens junction assembly (GO:0007045)2.60529223
119negative regulation of acute inflammatory response (GO:0002674)2.60301926
120regulation of cardioblast differentiation (GO:0051890)2.59909961
121regulation of heart rate by cardiac conduction (GO:0086091)2.59800804
122negative regulation of kidney development (GO:0090185)2.59334399
123unsaturated fatty acid biosynthetic process (GO:0006636)2.58598080
124positive regulation of cholesterol transport (GO:0032376)2.58467604
125positive regulation of sterol transport (GO:0032373)2.58467604
126regulation of hair cycle (GO:0042634)2.57406838
127regulation of protein localization to cell surface (GO:2000008)2.55987623
128cellular copper ion homeostasis (GO:0006878)2.54787332
129very long-chain fatty acid metabolic process (GO:0000038)2.54588274
130negative regulation of actin filament bundle assembly (GO:0032232)2.54574158
131prostanoid biosynthetic process (GO:0046457)2.54487835
132prostaglandin biosynthetic process (GO:0001516)2.54487835
133viral transcription (GO:0019083)2.54287188
134cardiac right ventricle morphogenesis (GO:0003215)2.53843379
135epithelial cell-cell adhesion (GO:0090136)2.53514753
136serine transport (GO:0032329)2.53467195
137fibrinolysis (GO:0042730)2.52307524
138positive regulation of chemokine secretion (GO:0090197)2.51721116
139positive regulation of transforming growth factor beta production (GO:0071636)2.51509783
140membrane tubulation (GO:0097320)2.43430473
141mammary gland epithelial cell proliferation (GO:0033598)2.41385325
142membrane budding (GO:0006900)2.40979958
143epithelial cell proliferation (GO:0050673)2.39449587
144wound healing (GO:0042060)2.38075834
145cell-cell junction assembly (GO:0007043)2.34866759
146establishment of skin barrier (GO:0061436)17.2925483
147keratinization (GO:0031424)16.1741990
148regulation of water loss via skin (GO:0033561)15.1571249
149desmosome organization (GO:0002934)14.7925230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.87442127
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.33276813
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.77417928
4ZNF263_19887448_ChIP-Seq_K562_Human2.63040085
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46946680
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.42839612
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31085012
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17937048
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.16836414
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07094314
11TP63_17297297_ChIP-ChIP_HaCaT_Human14.6705696
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.98937714
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98921445
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98921445
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.86127377
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.77080632
17TCF4_18268006_ChIP-ChIP_LS174T_Human1.65965622
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65879381
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54397927
20* TP63_23658742_ChIP-Seq_EP156T_Human1.52626131
21SOX2_20726797_ChIP-Seq_SW620_Human1.47690292
22GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.46843769
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41623021
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41293166
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37968471
26RXR_22108803_ChIP-Seq_LS180_Human1.36200634
27* TP63_22573176_ChIP-Seq_HFKS_Human1.33467543
28TP53_18474530_ChIP-ChIP_U2OS_Human1.29600061
29KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26406694
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.26210064
31CJUN_26792858_Chip-Seq_BT549_Human1.25541512
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.25340450
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23498904
34GATA3_24758297_ChIP-Seq_MCF-7_Human1.22836064
35KLF5_25053715_ChIP-Seq_YYC3_Human1.21751539
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21427770
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.21373748
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19567666
39ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18904612
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18773952
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.17793218
42CEBPB_22108803_ChIP-Seq_LS180_Human1.16823771
43ATF3_27146783_Chip-Seq_COLON_Human1.15966289
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15299313
45CLOCK_20551151_ChIP-Seq_293T_Human1.15033753
46P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11837460
47AR_21572438_ChIP-Seq_LNCaP_Human1.11507009
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09494270
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08875570
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.07171527
51GATA4_25053715_ChIP-Seq_YYC3_Human1.06850016
52RACK7_27058665_Chip-Seq_MCF-7_Human1.06303272
53CTCF_27219007_Chip-Seq_Bcells_Human1.05378532
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04495463
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04326372
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03489670
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02291925
58TP53_20018659_ChIP-ChIP_R1E_Mouse0.98665148
59AR_21909140_ChIP-Seq_LNCAP_Human0.96981297
60SMC4_20622854_ChIP-Seq_HELA_Human0.96886583
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96585447
62UBF1/2_26484160_Chip-Seq_HMECs_Human0.95080619
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95001893
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93930725
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93594865
66EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93017167
67AHR_22903824_ChIP-Seq_MCF-7_Human0.92147479
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92141240
69BCAT_22108803_ChIP-Seq_LS180_Human0.91996661
70DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90748975
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90338074
72SA1_27219007_Chip-Seq_ERYTHROID_Human0.90310300
73EZH2_27304074_Chip-Seq_ESCs_Mouse0.89911341
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89320700
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88044359
76ESR1_20079471_ChIP-ChIP_T-47D_Human0.88021245
77NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87131318
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86461995
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86248843
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85684474
81YY1_22570637_ChIP-Seq_MALME-3M_Human0.85584791
82VDR_22108803_ChIP-Seq_LS180_Human0.85159573
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84968536
84EGR1_19032775_ChIP-ChIP_M12_Human0.84694764
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.83495769
86GATA6_25053715_ChIP-Seq_YYC3_Human0.83285964
87TCF4_22108803_ChIP-Seq_LS180_Human0.83011851
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82973773
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81850197
90RBPJ_21746931_ChIP-Seq_IB4_Human0.81401465
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81125968
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.80867556
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80701842
94LXR_22292898_ChIP-Seq_THP-1_Human0.79372573
95TP53_16413492_ChIP-PET_HCT116_Human0.79065944
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.79056501
97CTCF_20526341_ChIP-Seq_ESCs_Human0.77434316
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77202797
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.76541063
100SA1_27219007_Chip-Seq_Bcells_Human0.76287885
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75231277
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74819440
103GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74396852
104BCOR_27268052_Chip-Seq_Bcells_Human0.73578643
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.72908357
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72458708
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72364368
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.72195809
109E2F1_20622854_ChIP-Seq_HELA_Human0.72060346
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71329636
111EED_16625203_ChIP-ChIP_MESCs_Mouse0.70244167
112OCT1_27270436_Chip-Seq_PROSTATE_Human0.70043766
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.69743328
114RNF2_27304074_Chip-Seq_ESCs_Mouse0.68911310
115CSB_26484114_Chip-Seq_FIBROBLAST_Human0.68525356
116KDM2B_26808549_Chip-Seq_K562_Human0.68272419
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68195418
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68152131
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67966007
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.67961255
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.66586134
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.66549237
123JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.66357076
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.65895048
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.65895048
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.65633090
127PHF8_20622853_ChIP-Seq_HELA_Human0.65096188
128CBX2_22325352_ChIP-Seq_293T-Rex_Human0.64543470
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63261738
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62940782
131P68_20966046_ChIP-Seq_HELA_Human0.62704308
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62408381
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61979578
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.61797009
135FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.59434503
136ELF5_23300383_ChIP-Seq_T47D_Human0.55950542
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.55302408
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.54976953
139TP53_22127205_ChIP-Seq_IMR90_Human0.54962699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.07744267
2MP0005275_abnormal_skin_tensile6.71295480
3MP0005501_abnormal_skin_physiology5.59526036
4MP0010234_abnormal_vibrissa_follicle5.45231942
5MP0003941_abnormal_skin_development4.91998141
6MP0005451_abnormal_body_composition4.29203620
7MP0000579_abnormal_nail_morphology3.99880776
8MP0004381_abnormal_hair_follicle3.81896882
9MP0002060_abnormal_skin_morphology3.55248854
10MP0001216_abnormal_epidermal_layer3.53550252
11MP0010771_integument_phenotype3.36747799
12MP0004947_skin_inflammation3.04375017
13MP0002098_abnormal_vibrissa_morphology2.82600023
14MP0010678_abnormal_skin_adnexa2.75394417
15MP0000647_abnormal_sebaceous_gland2.70441510
16MP0003453_abnormal_keratinocyte_physiol2.63136217
17MP0000383_abnormal_hair_follicle2.51792449
18MP0002254_reproductive_system_inflammat2.49775602
19MP0003705_abnormal_hypodermis_morpholog2.42288026
20MP0000377_abnormal_hair_follicle2.41289295
21MP0000427_abnormal_hair_cycle2.33964567
22MP0000467_abnormal_esophagus_morphology2.03307171
23MP0009931_abnormal_skin_appearance1.83286918
24MP0003191_abnormal_cellular_cholesterol1.69734361
25MP0001191_abnormal_skin_condition1.67608689
26MP0000762_abnormal_tongue_morphology1.62598994
27MP0004185_abnormal_adipocyte_glucose1.56977757
28MP0001243_abnormal_dermal_layer1.53162919
29MP0003566_abnormal_cell_adhesion1.48779351
30MP0000367_abnormal_coat/_hair1.39970541
31MP0000566_synostosis1.36287407
32MP0004885_abnormal_endolymph1.31024446
33MP0003878_abnormal_ear_physiology1.24067591
34MP0005377_hearing/vestibular/ear_phenot1.24067591
35MP0001346_abnormal_lacrimal_gland1.22475117
36MP0000678_abnormal_parathyroid_gland1.18934227
37MP0008260_abnormal_autophagy1.18200999
38MP0002009_preneoplasia1.15463424
39MP0004782_abnormal_surfactant_physiolog1.05898852
40MP0009379_abnormal_foot_pigmentation0.97564071
41MP0000465_gastrointestinal_hemorrhage0.95322044
42MP0001340_abnormal_eyelid_morphology0.89186186
43MP0001188_hyperpigmentation0.87333446
44MP0001851_eye_inflammation0.85498852
45MP0003806_abnormal_nucleotide_metabolis0.83709876
46MP0010352_gastrointestinal_tract_polyps0.81129724
47MP0005257_abnormal_intraocular_pressure0.80726253
48MP0002234_abnormal_pharynx_morphology0.80184806
49MP0005075_abnormal_melanosome_morpholog0.72645860
50MP0001784_abnormal_fluid_regulation0.69678032
51MP0000858_altered_metastatic_potential0.67449962
52MP0009053_abnormal_anal_canal0.65751926
53MP0002095_abnormal_skin_pigmentation0.62404245
54MP0003950_abnormal_plasma_membrane0.57488686
55MP0002177_abnormal_outer_ear0.56826902
56MP0005367_renal/urinary_system_phenotyp0.56538402
57MP0000516_abnormal_urinary_system0.56538402
58MP0009780_abnormal_chondrocyte_physiolo0.53940406
59MP0008004_abnormal_stomach_pH0.53761441
60MP0005023_abnormal_wound_healing0.51376008
61MP0000462_abnormal_digestive_system0.50665081
62MP0003315_abnormal_perineum_morphology0.49978742
63MP0005409_darkened_coat_color0.49271827
64MP0002877_abnormal_melanocyte_morpholog0.49189773
65MP0005666_abnormal_adipose_tissue0.47139533
66MP0010030_abnormal_orbit_morphology0.46532432
67MP0001984_abnormal_olfaction0.46362172
68MP0003011_delayed_dark_adaptation0.44731519
69MP0003763_abnormal_thymus_physiology0.43144578
70MP0005076_abnormal_cell_differentiation0.41471701
71MP0000627_abnormal_mammary_gland0.39735376
72MP0005197_abnormal_uvea_morphology0.39712190
73MP0005360_urolithiasis0.39354147
74MP0005330_cardiomyopathy0.38293684
75MP0000015_abnormal_ear_pigmentation0.38088788
76MP0005193_abnormal_anterior_eye0.37905964
77MP0005394_taste/olfaction_phenotype0.37030662
78MP0005499_abnormal_olfactory_system0.37030662
79MP0001661_extended_life_span0.35455995
80MP0002282_abnormal_trachea_morphology0.34983904
81MP0004019_abnormal_vitamin_homeostasis0.34593454
82MP0003755_abnormal_palate_morphology0.34547379
83MP0008961_abnormal_basal_metabolism0.33898346
84MP0006138_congestive_heart_failure0.33365819
85MP0001177_atelectasis0.33021282
86MP0003091_abnormal_cell_migration0.32678638
87MP0003329_amyloid_beta_deposits0.31971064
88MP0003045_fibrosis0.31915230
89MP0002006_tumorigenesis0.31533705
90MP0003786_premature_aging0.31406676
91MP0002111_abnormal_tail_morphology0.30762402
92MP0002166_altered_tumor_susceptibility0.30679464
93MP0005248_abnormal_Harderian_gland0.30209661
94MP0005375_adipose_tissue_phenotype0.30204693
95MP0004858_abnormal_nervous_system0.29830558
96MP0001881_abnormal_mammary_gland0.29580369
97MP0005621_abnormal_cell_physiology0.28490139
98MP0002295_abnormal_pulmonary_circulatio0.28032338
99MP0008932_abnormal_embryonic_tissue0.27999066
100MP0000537_abnormal_urethra_morphology0.27382728
101MP0000003_abnormal_adipose_tissue0.27277202
102MP0006054_spinal_hemorrhage0.26698966
103MP0000470_abnormal_stomach_morphology0.26443404
104MP0001849_ear_inflammation0.25970144
105MP0004264_abnormal_extraembryonic_tissu0.25352553
106MP0000750_abnormal_muscle_regeneration0.23496262
107MP0003448_altered_tumor_morphology0.22456075
108MP0004272_abnormal_basement_membrane0.20708895
109MP0000538_abnormal_urinary_bladder0.19929407
110MP0003638_abnormal_response/metabolism_0.19302829
111MP0002233_abnormal_nose_morphology0.18844551
112MP0002090_abnormal_vision0.18266564
113MP0003385_abnormal_body_wall0.18245194
114MP0001542_abnormal_bone_strength0.18217389
115MP0000432_abnormal_head_morphology0.18184049
116MP0002249_abnormal_larynx_morphology0.17441308
117MP0002896_abnormal_bone_mineralization0.15186743
118MP0008789_abnormal_olfactory_epithelium0.15045164
119MP0002697_abnormal_eye_size0.14715043
120MP0003436_decreased_susceptibility_to0.14599715
121MP0009672_abnormal_birth_weight0.14332240
122MP0005388_respiratory_system_phenotype0.13665034
123MP0002133_abnormal_respiratory_system0.13665034
124MP0008438_abnormal_cutaneous_collagen0.13398392
125MP0005508_abnormal_skeleton_morphology0.13262794
126MP0002277_abnormal_respiratory_mucosa0.13259695
127MP0001299_abnormal_eye_distance/0.12595504
128MP0004197_abnormal_fetal_growth/weight/0.12274139
129MP0005623_abnormal_meninges_morphology0.11397120
130MP0009250_abnormal_appendicular_skeleto0.11223437
131MP0002148_abnormal_hypersensitivity_rea0.11199831

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.31414093
2Congenital ichthyosiform erythroderma (HP:0007431)8.23685309
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.12772070
4Hypotrichosis (HP:0001006)7.83008597
5Abnormality of nail color (HP:0100643)7.68915999
6Palmoplantar hyperkeratosis (HP:0000972)7.17522040
7Plantar hyperkeratosis (HP:0007556)6.96402965
8Palmar hyperkeratosis (HP:0010765)6.78491758
9Woolly hair (HP:0002224)6.57211324
10Erythroderma (HP:0001019)6.56079391
11Erythema (HP:0010783)6.33847316
12Conjunctival hamartoma (HP:0100780)6.21957061
13Right ventricular cardiomyopathy (HP:0011663)6.13379550
14Onycholysis (HP:0001806)5.91617216
15Parakeratosis (HP:0001036)5.37893161
16Lip pit (HP:0100267)4.96212309
17Fragile nails (HP:0001808)4.87294433
18Gangrene (HP:0100758)4.84852387
19Pili torti (HP:0003777)4.45352429
20Ectropion (HP:0000656)4.42444707
21Corneal erosion (HP:0200020)4.35901504
22Thick nail (HP:0001805)4.12299589
23Abnormal blistering of the skin (HP:0008066)4.11908992
24Hypohidrosis (HP:0000966)3.96034139
25Milia (HP:0001056)3.87044348
26Nail dystrophy (HP:0008404)3.84514526
27Natal tooth (HP:0000695)3.84107911
28Hyporeflexia of lower limbs (HP:0002600)3.81321162
29Palmoplantar keratoderma (HP:0000982)3.77597467
30Hamartoma of the eye (HP:0010568)3.77129591
31Selective tooth agenesis (HP:0001592)3.73141645
32Pruritus (HP:0000989)3.70941476
33Curly hair (HP:0002212)3.69749850
34Advanced eruption of teeth (HP:0006288)3.37812618
35Ventricular tachycardia (HP:0004756)3.28618909
36Distal lower limb muscle weakness (HP:0009053)3.22013161
37Sparse eyelashes (HP:0000653)3.20974297
38Sparse scalp hair (HP:0002209)3.16794732
39Absent eyelashes (HP:0000561)3.15352761
40Hypoplasia of dental enamel (HP:0006297)3.09095139
41Pterygium (HP:0001059)3.03443447
42Acanthosis nigricans (HP:0000956)2.93049237
43Hypergammaglobulinemia (HP:0010702)2.81787153
44Lack of skin elasticity (HP:0100679)2.78250516
45Alopecia of scalp (HP:0002293)2.76012991
46Abnormal hair laboratory examination (HP:0003328)2.74282239
47Amniotic constriction ring (HP:0009775)2.71231639
48Abnormality of placental membranes (HP:0011409)2.71231639
49Areflexia of lower limbs (HP:0002522)2.66022825
50Eczematoid dermatitis (HP:0000976)2.60448151
51Aplasia cutis congenita (HP:0001057)2.60327116
52Carious teeth (HP:0000670)2.46636682
53Abnormality of the salivary glands (HP:0010286)2.44601920
54Abnormality of secondary sexual hair (HP:0009888)2.42478180
55Abnormality of the axillary hair (HP:0100134)2.42478180
56Brittle hair (HP:0002299)2.38258164
57Ridged nail (HP:0001807)2.32969005
58Dry skin (HP:0000958)2.25542507
59Dehydration (HP:0001944)2.24122249
60Ankyloglossia (HP:0010296)2.21179120
61Dry hair (HP:0011359)2.18661247
62Absent hair (HP:0002298)2.17402812
63Popliteal pterygium (HP:0009756)2.05628844
64Malignant hyperthermia (HP:0002047)2.04970445
65Pustule (HP:0200039)2.04680425
66Abnormality of the fingernails (HP:0001231)2.04547203
67Ventricular fibrillation (HP:0001663)2.04329310
68Congenital, generalized hypertrichosis (HP:0004540)2.02801181
69Atrophic scars (HP:0001075)2.02303354
70Corneal dystrophy (HP:0001131)2.01031033
71Paralysis (HP:0003470)1.99850601
72Hyperhidrosis (HP:0000975)1.96482679
73Oligodontia (HP:0000677)1.90260070
74Trismus (HP:0000211)1.88522275
75Blepharitis (HP:0000498)1.87414702
76Hypodontia (HP:0000668)1.87160841
77Abnormality of the gastric mucosa (HP:0004295)1.85256233
78Skin ulcer (HP:0200042)1.84609461
79Follicular hyperkeratosis (HP:0007502)1.82755367
80Amelogenesis imperfecta (HP:0000705)1.79836734
81Epidermoid cyst (HP:0200040)1.78526541
82Premature ovarian failure (HP:0008209)1.77908949
83Abnormality of permanent molar morphology (HP:0011071)1.77093573
84Abnormality of the dental root (HP:0006486)1.77093573
85Taurodontia (HP:0000679)1.77093573
86Hamartoma (HP:0010566)1.76705485
87Achilles tendon contracture (HP:0001771)1.76301733
88Sudden death (HP:0001699)1.75226617
89Autoamputation (HP:0001218)1.74897464
90Severe Myopia (HP:0011003)1.72971412
91Increased connective tissue (HP:0009025)1.71689100
92Abnormality of oral frenula (HP:0000190)1.71193087
93Ulnar claw (HP:0001178)1.70784995
94Multifactorial inheritance (HP:0001426)1.70503396
95Sepsis (HP:0100806)1.68849091
96Anonychia (HP:0001798)1.68770242
97Breast hypoplasia (HP:0003187)1.67917202
98Melanocytic nevus (HP:0000995)1.66772361
99Round ear (HP:0100830)1.66316377
100Slow-growing hair (HP:0002217)1.65973546
101Abnormality of hair growth rate (HP:0011363)1.65973546
102Distal arthrogryposis (HP:0005684)1.64383396
103Septate vagina (HP:0001153)1.63133224
104Abnormality of the neuromuscular junction (HP:0003398)1.62545574
105Fatigable weakness (HP:0003473)1.62545574
106Abnormality of the Achilles tendon (HP:0005109)1.62095731
107Abnormality of molar morphology (HP:0011070)1.62034836
108Abnormality of molar (HP:0011077)1.62034836
109Short nail (HP:0001799)1.61337587
110Concave nail (HP:0001598)1.61205500
111Hypoplastic labia majora (HP:0000059)1.59370625
112Laryngomalacia (HP:0001601)1.56596495
113Labial hypoplasia (HP:0000066)1.54652682
114Cheilitis (HP:0100825)1.53741338
115Asthma (HP:0002099)1.53150880
116Urticaria (HP:0001025)1.52284166
117Abnormality of the dental pulp (HP:0006479)1.51871867
118Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.51208238
119Split foot (HP:0001839)1.50841261
120Skin pits (HP:0100276)1.49168523
121Type 1 muscle fiber predominance (HP:0003803)1.49130195
122Hypoplastic female external genitalia (HP:0012815)1.48494801
123Myopathic facies (HP:0002058)1.47637938
124Sensory axonal neuropathy (HP:0003390)1.45958677
125Esophageal atresia (HP:0002032)1.45504101
126Vascular calcification (HP:0004934)1.43955489
127Fasciculations (HP:0002380)1.42815404
128Abnormality of the labia majora (HP:0012881)1.42512026
129Hydroureter (HP:0000072)1.42238215
130Fine hair (HP:0002213)1.41944753
131Abnormality of the distal phalanges of the toes (HP:0010182)1.41110711
132Oral leukoplakia (HP:0002745)1.39112867
133Neonatal death (HP:0003811)1.39075111
134Nemaline bodies (HP:0003798)1.37455732
135Villous atrophy (HP:0011473)1.36858057
136Abnormality of small intestinal villus morphology (HP:0011472)1.36858057
137Neck muscle weakness (HP:0000467)1.36730664
138Fragile skin (HP:0001030)1.36011358
139Muscle fiber inclusion bodies (HP:0100299)1.35743862
140Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.35314799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK36.67005712
2MST45.92366216
3FER3.61026108
4ARAF3.55160968
5MST1R3.47833047
6MAP3K33.45295063
7LATS12.95775642
8RPS6KB22.74728908
9EPHB22.57679867
10NTRK12.53495182
11SIK12.44527425
12MAP3K22.36688737
13PAK42.12624062
14MAP3K91.90431736
15PIK3CG1.81655325
16PIM21.78711519
17FLT31.77653159
18PBK1.71567920
19ERN11.67879246
20TRPM71.59859075
21FGFR11.58694796
22MAP3K111.52328125
23BLK1.48267855
24TAOK11.46708336
25SMG11.46274848
26EPHA21.44854798
27BCR1.40075317
28LRRK21.39703164
29MAP2K61.39175082
30TESK11.38289863
31EPHA31.38186603
32MAPKAPK51.34541995
33MAP3K71.26583877
34STK101.24327747
35MAP3K11.22539143
36TTN1.20819241
37LATS21.19959364
38STK241.19340592
39PDGFRA1.18517353
40STK381.16505116
41LIMK11.15990348
42ERBB31.14932471
43MET1.13811506
44MYLK1.11511315
45BMPR1B1.11125784
46EEF2K1.09572969
47PTK61.06610986
48BRAF1.03633712
49ABL20.99828047
50RAF10.99029940
51MAPKAPK20.96331922
52OBSCN0.92018711
53RIPK40.91062587
54GRK10.90150838
55MAP2K30.90057092
56IRAK30.88990211
57MAP3K140.88057610
58FGFR40.87839134
59DYRK1B0.87236372
60EPHB10.86740397
61FGFR20.78658084
62NME10.77546507
63CDK60.73612304
64NTRK20.71455961
65GRK50.70249722
66CDK120.70137523
67PAK30.67795738
68ITK0.67589149
69MAP3K120.66866163
70BUB10.65930156
71FGFR30.64287891
72MAP2K40.60876447
73LMTK20.59916078
74MAP2K10.59762904
75MAP3K50.58655898
76MAP3K80.56778600
77IRAK20.55740610
78CAMK2G0.54664078
79TGFBR20.54574732
80PKN10.53585337
81IRAK10.52883105
82ROCK20.52670407
83PRKD10.52629832
84NEK90.51896691
85PRKCI0.50397545
86RPS6KA20.49936481
87FGR0.49779440
88GRK70.46015803
89CASK0.45732448
90CSNK1D0.45284951
91MAP2K20.44464146
92RET0.44286600
93PDGFRB0.43175439
94ADRBK10.42818148
95RPS6KA10.42615330
96PTK20.42377628
97EIF2AK10.41270255
98STK38L0.40314801
99CDK190.39951053
100IKBKB0.39266805
101BMX0.38876662
102MAP3K60.38033126
103RIPK10.37954304
104SIK30.37062557
105MTOR0.36838165
106TRIB30.36620396
107KSR10.36393959
108TGFBR10.35393488
109ILK0.34195962
110ROCK10.32457471
111ERBB40.30657322
112TYRO30.30514821
113JAK30.28889534
114CDK30.28203295
115PRKD20.28032462
116ERBB20.27956099
117TAOK20.26513491
118NME20.25736054
119RPS6KA40.25621990
120ZAP700.25597899
121KSR20.25420217
122PRKCE0.25252211
123NEK60.25233965
124AURKA0.23569754
125CDK90.23554137
126MAPK120.23343677
127MAPK40.23201394
128TYK20.22423568
129JAK20.22333978
130EPHA40.21207137
131CSF1R0.20758133
132HCK0.20154253
133CDC42BPA0.20055601
134TSSK60.19245866
135DDR20.18892816
136DMPK0.18506781
137CSNK1A1L0.18109286
138PRKCA0.18108020
139MAPK90.17372183
140STK30.17280089
141EIF2AK20.16829979
142HIPK20.16347653
143GSK3A0.15574570
144TESK20.15376497
145CAMK2B0.15209250
146NEK10.14118820
147AURKB0.13827753

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.93676107
2Sphingolipid metabolism_Homo sapiens_hsa006003.87063702
3Linoleic acid metabolism_Homo sapiens_hsa005913.49985254
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.46243446
5Fatty acid elongation_Homo sapiens_hsa000623.14312855
6Arachidonic acid metabolism_Homo sapiens_hsa005903.03864559
7Proteasome_Homo sapiens_hsa030502.89761007
8Small cell lung cancer_Homo sapiens_hsa052222.82532114
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31909641
10Histidine metabolism_Homo sapiens_hsa003402.16826789
11Ether lipid metabolism_Homo sapiens_hsa005652.13284822
12Focal adhesion_Homo sapiens_hsa045102.09678828
13Ribosome_Homo sapiens_hsa030101.91561429
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90762725
15Phenylalanine metabolism_Homo sapiens_hsa003601.88659146
16Staphylococcus aureus infection_Homo sapiens_hsa051501.66376024
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66367764
18Galactose metabolism_Homo sapiens_hsa000521.64998062
19VEGF signaling pathway_Homo sapiens_hsa043701.58931761
20Phototransduction_Homo sapiens_hsa047441.57905163
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50481703
22Tight junction_Homo sapiens_hsa045301.49661397
23ABC transporters_Homo sapiens_hsa020101.46297742
24Axon guidance_Homo sapiens_hsa043601.43836072
25GnRH signaling pathway_Homo sapiens_hsa049121.42131231
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37819007
27Sphingolipid signaling pathway_Homo sapiens_hsa040711.34688755
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33859218
29Fat digestion and absorption_Homo sapiens_hsa049751.33673080
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28700087
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21079681
32Adherens junction_Homo sapiens_hsa045201.15975658
33Pancreatic cancer_Homo sapiens_hsa052121.15356630
34Renin secretion_Homo sapiens_hsa049241.15169472
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14646071
36Steroid biosynthesis_Homo sapiens_hsa001001.13502846
37Retinol metabolism_Homo sapiens_hsa008301.12672758
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12489920
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.11862104
40Collecting duct acid secretion_Homo sapiens_hsa049661.11169907
41Chronic myeloid leukemia_Homo sapiens_hsa052201.09045801
42Melanogenesis_Homo sapiens_hsa049161.06832944
43Shigellosis_Homo sapiens_hsa051311.05329200
44Pertussis_Homo sapiens_hsa051331.03553828
45Serotonergic synapse_Homo sapiens_hsa047261.03320999
46Basal cell carcinoma_Homo sapiens_hsa052171.02278547
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99837588
48Notch signaling pathway_Homo sapiens_hsa043300.99523302
49Long-term potentiation_Homo sapiens_hsa047200.97369720
50Pancreatic secretion_Homo sapiens_hsa049720.96656696
51Fructose and mannose metabolism_Homo sapiens_hsa000510.95459197
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94655335
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.93139861
54Tyrosine metabolism_Homo sapiens_hsa003500.92723294
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92126341
56Pathways in cancer_Homo sapiens_hsa052000.90762053
57Olfactory transduction_Homo sapiens_hsa047400.90249160
58ECM-receptor interaction_Homo sapiens_hsa045120.89656953
59p53 signaling pathway_Homo sapiens_hsa041150.89604948
60Renal cell carcinoma_Homo sapiens_hsa052110.89181454
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87683403
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.87408573
63N-Glycan biosynthesis_Homo sapiens_hsa005100.87122888
64Ras signaling pathway_Homo sapiens_hsa040140.87080473
65Gastric acid secretion_Homo sapiens_hsa049710.86408735
66Bladder cancer_Homo sapiens_hsa052190.85934786
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.85423977
68Hippo signaling pathway_Homo sapiens_hsa043900.82570334
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81776638
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80521101
71Ovarian steroidogenesis_Homo sapiens_hsa049130.80302912
72Proteoglycans in cancer_Homo sapiens_hsa052050.79281865
73Dilated cardiomyopathy_Homo sapiens_hsa054140.76715323
74Insulin signaling pathway_Homo sapiens_hsa049100.75737012
75Fatty acid biosynthesis_Homo sapiens_hsa000610.75661277
76Long-term depression_Homo sapiens_hsa047300.75028906
77Prion diseases_Homo sapiens_hsa050200.74347144
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74076562
79Glioma_Homo sapiens_hsa052140.73003387
80Amoebiasis_Homo sapiens_hsa051460.72770591
81Endometrial cancer_Homo sapiens_hsa052130.72248093
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72242032
83Dorso-ventral axis formation_Homo sapiens_hsa043200.72131410
84Folate biosynthesis_Homo sapiens_hsa007900.71823793
85Chemical carcinogenesis_Homo sapiens_hsa052040.71657539
86Oxytocin signaling pathway_Homo sapiens_hsa049210.70918714
87Hedgehog signaling pathway_Homo sapiens_hsa043400.70493791
88Estrogen signaling pathway_Homo sapiens_hsa049150.70419802
89Other glycan degradation_Homo sapiens_hsa005110.68603475
90ErbB signaling pathway_Homo sapiens_hsa040120.67823971
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67768021
92Lysosome_Homo sapiens_hsa041420.66455851
93Hepatitis C_Homo sapiens_hsa051600.64756224
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63663448
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61912693
96Platelet activation_Homo sapiens_hsa046110.61194777
97beta-Alanine metabolism_Homo sapiens_hsa004100.59689834
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58720634
99MicroRNAs in cancer_Homo sapiens_hsa052060.58039894
100Protein digestion and absorption_Homo sapiens_hsa049740.56092144
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55886460
102Mineral absorption_Homo sapiens_hsa049780.55549176
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.55498719
104Salivary secretion_Homo sapiens_hsa049700.55237947
105Pentose phosphate pathway_Homo sapiens_hsa000300.55167323
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55117267
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54624477
108Non-small cell lung cancer_Homo sapiens_hsa052230.53701945
109Apoptosis_Homo sapiens_hsa042100.52725665
110TGF-beta signaling pathway_Homo sapiens_hsa043500.52585218
111Thyroid cancer_Homo sapiens_hsa052160.51995294
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50852768
113Toxoplasmosis_Homo sapiens_hsa051450.49964847
114Acute myeloid leukemia_Homo sapiens_hsa052210.49433683
115Endocytosis_Homo sapiens_hsa041440.48324958
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47201662
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.45920472
118Inositol phosphate metabolism_Homo sapiens_hsa005620.45153440
119Rap1 signaling pathway_Homo sapiens_hsa040150.44956671
120Melanoma_Homo sapiens_hsa052180.44756201
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44354913
122Tuberculosis_Homo sapiens_hsa051520.43323936
123Wnt signaling pathway_Homo sapiens_hsa043100.42650809
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42292027
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41822301
126Caffeine metabolism_Homo sapiens_hsa002320.41677551
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40146272
128Circadian rhythm_Homo sapiens_hsa047100.39072648
129Choline metabolism in cancer_Homo sapiens_hsa052310.38758188
130Dopaminergic synapse_Homo sapiens_hsa047280.37387987
131Sulfur metabolism_Homo sapiens_hsa009200.37385967
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37014054
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36996396
134Calcium signaling pathway_Homo sapiens_hsa040200.36708010
135Prostate cancer_Homo sapiens_hsa052150.36268918
136Salmonella infection_Homo sapiens_hsa051320.35490054
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35150264
138Phagosome_Homo sapiens_hsa041450.34905124
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.34860999
140PPAR signaling pathway_Homo sapiens_hsa033200.34820596
141Vibrio cholerae infection_Homo sapiens_hsa051100.34236729
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.33590313
143Glycerolipid metabolism_Homo sapiens_hsa005610.31300496
144Gap junction_Homo sapiens_hsa045400.30483412
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30401601
146Circadian entrainment_Homo sapiens_hsa047130.30052539
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28352375

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