KLK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.12173942
2regulation of water loss via skin (GO:0033561)8.54686447
3establishment of skin barrier (GO:0061436)8.53351215
4response to methylmercury (GO:0051597)8.20494403
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.94487486
6long-chain fatty acid biosynthetic process (GO:0042759)6.82653022
7regulation of lipoprotein metabolic process (GO:0050746)6.43414605
8cholesterol biosynthetic process (GO:0006695)6.39501155
9long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.17725012
10myelin maintenance (GO:0043217)6.10922465
11skin morphogenesis (GO:0043589)6.05576499
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.96421422
13multicellular organismal water homeostasis (GO:0050891)5.85828063
14sterol biosynthetic process (GO:0016126)5.82123576
15hemidesmosome assembly (GO:0031581)5.74105780
16fatty-acyl-CoA biosynthetic process (GO:0046949)5.48098621
17negative regulation of protein localization to cell surface (GO:2000009)5.26977892
18fatty-acyl-CoA metabolic process (GO:0035337)5.23897838
19* ensheathment of neurons (GO:0007272)5.22226334
20* axon ensheathment (GO:0008366)5.22226334
21* myelination (GO:0042552)5.21205506
22astrocyte differentiation (GO:0048708)5.05424724
23establishment of mitochondrion localization (GO:0051654)4.99253384
24water homeostasis (GO:0030104)4.92342714
25negative regulation of neurotransmitter transport (GO:0051589)4.90664617
26very long-chain fatty acid metabolic process (GO:0000038)4.86928807
27keratinocyte proliferation (GO:0043616)4.79348162
28keratinocyte differentiation (GO:0030216)4.72211711
29isoprenoid biosynthetic process (GO:0008299)4.70165909
30regulation of collateral sprouting (GO:0048670)4.67126286
31protein retention in ER lumen (GO:0006621)4.62066437
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.60247686
33activation of Rac GTPase activity (GO:0032863)4.50056281
34amyloid precursor protein catabolic process (GO:0042987)4.47070628
35L-amino acid import (GO:0043092)4.45709658
36proteasome assembly (GO:0043248)4.45252261
37negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.39967308
38thioester biosynthetic process (GO:0035384)4.39468426
39acyl-CoA biosynthetic process (GO:0071616)4.39468426
40* amyloid precursor protein metabolic process (GO:0042982)4.33472604
41positive regulation of oligodendrocyte differentiation (GO:0048714)4.30023757
42gap junction assembly (GO:0016264)4.25602743
43regulation of transforming growth factor beta2 production (GO:0032909)4.15100482
44epidermis development (GO:0008544)4.07545562
45epidermal cell differentiation (GO:0009913)4.00482342
46negative regulation of keratinocyte proliferation (GO:0010839)3.94259485
47extracellular matrix assembly (GO:0085029)3.92673395
48negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.91462957
49creatine metabolic process (GO:0006600)3.90865564
50regulation of phospholipase A2 activity (GO:0032429)3.90687728
51response to lipoprotein particle (GO:0055094)3.87161913
52membrane tubulation (GO:0097320)3.86002979
53peptide cross-linking (GO:0018149)3.82254008
54hepatocyte apoptotic process (GO:0097284)3.78753414
55L-serine transport (GO:0015825)3.76974105
56negative regulation of neurotransmitter secretion (GO:0046929)3.75356381
57positive regulation of Cdc42 GTPase activity (GO:0043089)3.65297338
58import into cell (GO:0098657)3.63124111
59positive regulation of epidermal cell differentiation (GO:0045606)3.60101551
60membrane budding (GO:0006900)3.59471030
61neurotransmitter uptake (GO:0001504)3.56451636
62negative regulation of skeletal muscle tissue development (GO:0048642)3.53788056
63protein neddylation (GO:0045116)3.52487479
64magnesium ion transport (GO:0015693)3.51259530
65regulation of mitotic spindle organization (GO:0060236)3.49985373
66regulation of cytokine production involved in inflammatory response (GO:1900015)3.47768675
67regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.47443385
68prostaglandin biosynthetic process (GO:0001516)3.43199720
69prostanoid biosynthetic process (GO:0046457)3.43199720
70positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.40927718
71axon development (GO:0061564)3.40195749
72regulation of cellular amino acid metabolic process (GO:0006521)3.39527004
73heme transport (GO:0015886)3.38295760
74molting cycle (GO:0042303)3.37428830
75hair cycle (GO:0042633)3.37428830
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.36884827
77branching involved in salivary gland morphogenesis (GO:0060445)3.33295154
78regulation of skeletal muscle cell differentiation (GO:2001014)3.33160086
79peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.33056645
80establishment of protein localization to plasma membrane (GO:0090002)3.31069202
81positive regulation of epidermis development (GO:0045684)3.30771277
82membrane raft organization (GO:0031579)3.30433228
83glycerophospholipid catabolic process (GO:0046475)3.29488486
84ether lipid metabolic process (GO:0046485)3.23629742
85coenzyme catabolic process (GO:0009109)3.22708713
86protein prenylation (GO:0018342)3.22225140
87prenylation (GO:0097354)3.22225140
88substantia nigra development (GO:0021762)3.19796191
89negative regulation of chemokine production (GO:0032682)3.19234352
90amino acid import (GO:0043090)3.18867133
91peptidyl-tyrosine autophosphorylation (GO:0038083)3.18761743
92iron coordination entity transport (GO:1901678)3.16817466
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16288315
94glycosylceramide metabolic process (GO:0006677)3.15140373
95negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.14516563
96phosphatidylserine acyl-chain remodeling (GO:0036150)3.13245521
97serine transport (GO:0032329)3.12621422
98deoxyribose phosphate biosynthetic process (GO:0046385)3.12413881
992-deoxyribonucleotide biosynthetic process (GO:0009265)3.12413881
100eye photoreceptor cell differentiation (GO:0001754)3.07468493
101photoreceptor cell differentiation (GO:0046530)3.07468493
102positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.04735575
103cell-substrate junction assembly (GO:0007044)3.04565643
104alcohol biosynthetic process (GO:0046165)3.03149474
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02335878
106detection of temperature stimulus involved in sensory perception (GO:0050961)3.02043933
107detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.02043933
108keratinocyte development (GO:0003334)3.00437969
109response to redox state (GO:0051775)2.99576020
110protein palmitoylation (GO:0018345)2.99542650
111regulation of spindle organization (GO:0090224)2.99061559
112negative regulation of adherens junction organization (GO:1903392)2.97617655
113negative regulation of focal adhesion assembly (GO:0051895)2.97617655
114negative regulation of cell junction assembly (GO:1901889)2.97617655
115thioester metabolic process (GO:0035383)2.97458750
116acyl-CoA metabolic process (GO:0006637)2.97458750
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96673523
118ectoderm development (GO:0007398)2.96313719
119triglyceride biosynthetic process (GO:0019432)2.95918482
120cofactor catabolic process (GO:0051187)2.95523632
121negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93597655
122sodium ion export (GO:0071436)2.92251260
123positive regulation of cellular amine metabolic process (GO:0033240)2.92109954
124keratinization (GO:0031424)2.90427218
125neuron remodeling (GO:0016322)2.89579846
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88328574
127nucleoside salvage (GO:0043174)2.88097859
128* positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.87376456
129negative regulation of ligase activity (GO:0051352)2.87152428
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87152428
131cell communication involved in cardiac conduction (GO:0086065)2.84705670
132cholesterol metabolic process (GO:0008203)2.83245329
133lipopolysaccharide biosynthetic process (GO:0009103)2.82107345
134glycine transport (GO:0015816)2.81418489
135regulation of G0 to G1 transition (GO:0070316)2.81072844
136cell-cell junction assembly (GO:0007043)2.80142822
137regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.80096033
138regulation of cardioblast differentiation (GO:0051890)2.80047467
139Golgi transport vesicle coating (GO:0048200)2.79187445
140COPI coating of Golgi vesicle (GO:0048205)2.79187445
141astrocyte development (GO:0014002)2.79048837
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.78728439
143regulation of hair cycle (GO:0042634)2.78416668
144neutral lipid biosynthetic process (GO:0046460)2.78382508
145acylglycerol biosynthetic process (GO:0046463)2.78382508
146negative regulation of response to reactive oxygen species (GO:1901032)2.77977076
147GPI anchor biosynthetic process (GO:0006506)2.77849911
148negative regulation of protein tyrosine kinase activity (GO:0061099)2.76172282
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.75896665
150signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.75896665
151regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73227181
152regulation of keratinocyte proliferation (GO:0010837)2.72499497
153regulation of cellular amine metabolic process (GO:0033238)2.71850838
154positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.70655721
155glutamate secretion (GO:0014047)2.70379397
156focal adhesion assembly (GO:0048041)2.70311989
157cell-substrate adherens junction assembly (GO:0007045)2.70311989
158signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67596343
159signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67596343
160signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67596343
161intermediate filament cytoskeleton organization (GO:0045104)2.66686996
162estrogen biosynthetic process (GO:0006703)2.66040246
163negative regulation of axonogenesis (GO:0050771)2.65971011
164GPI anchor metabolic process (GO:0006505)2.65597367
165phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64832167
166signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63427998
167signal transduction involved in DNA damage checkpoint (GO:0072422)2.63427998
168fatty acid biosynthetic process (GO:0006633)2.62985403
169sterol metabolic process (GO:0016125)2.62485524
170regulation of hydrogen peroxide-induced cell death (GO:1903205)2.62254545
171nerve growth factor signaling pathway (GO:0038180)2.61986349
172citrulline biosynthetic process (GO:0019240)2.60915846
173regulation of cholesterol biosynthetic process (GO:0045540)2.60765668
174cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.60588201
175positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59999425
176apical protein localization (GO:0045176)2.59985034
177regulation of exit from mitosis (GO:0007096)2.59906586
178negative regulation of cell fate specification (GO:0009996)2.59239989
179regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.59097775
180pyrimidine nucleoside salvage (GO:0043097)2.58496164
181protein localization to endosome (GO:0036010)2.57281957
182cellular response to cholesterol (GO:0071397)2.56849587
183response to dietary excess (GO:0002021)2.56447098
184mitochondrial calcium ion homeostasis (GO:0051560)2.55170319
185asymmetric protein localization (GO:0008105)2.53710508
186phosphatidylserine metabolic process (GO:0006658)2.53189115
187organ growth (GO:0035265)2.52786157
188phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.52731437
189central nervous system myelination (GO:0022010)12.0330727
190axon ensheathment in central nervous system (GO:0032291)12.0330727
191fatty acid elongation (GO:0030497)11.0318536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.95942174
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.17091480
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04312371
4ZNF263_19887448_ChIP-Seq_K562_Human2.70515892
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.68286932
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.54103128
7TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.46296989
8RACK7_27058665_Chip-Seq_MCF-7_Human2.45847241
9EZH2_22144423_ChIP-Seq_EOC_Human2.45006549
10KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.34849296
11* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.32874871
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.32874871
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31182810
14AR_21572438_ChIP-Seq_LNCaP_Human2.31020033
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28015769
16OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.21309967
17KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.19291044
18ATF3_27146783_Chip-Seq_COLON_Human2.16501398
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03594465
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.02385528
21* SOX2_20726797_ChIP-Seq_SW620_Human1.96575311
22GBX2_23144817_ChIP-Seq_PC3_Human1.92768231
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.90710589
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86650326
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86573055
26LXR_22292898_ChIP-Seq_THP-1_Human1.84365641
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80520062
28AR_21909140_ChIP-Seq_LNCAP_Human1.77820922
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77271198
30SMC4_20622854_ChIP-Seq_HELA_Human1.74835699
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.74346335
32TAF15_26573619_Chip-Seq_HEK293_Human1.72500722
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71086465
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70928153
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70920444
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69543116
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.69416415
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61605306
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60790867
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60690280
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.60514571
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.60479322
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60300857
44KLF5_25053715_ChIP-Seq_YYC3_Human1.60262984
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.59573671
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55211661
47ER_23166858_ChIP-Seq_MCF-7_Human1.53691613
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53466001
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53466001
50E2F7_22180533_ChIP-Seq_HELA_Human1.53381217
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52745884
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.52454914
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52427449
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51961547
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50140267
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48449836
57GATA6_25053715_ChIP-Seq_YYC3_Human1.47581377
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.47156295
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.45201194
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44866981
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.44273780
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43098235
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.42473866
64VDR_22108803_ChIP-Seq_LS180_Human1.41679030
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39997918
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39997918
67KDM2B_26808549_Chip-Seq_K562_Human1.39331591
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37527449
69* TP63_22573176_ChIP-Seq_HFKS_Human1.36968514
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34651939
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34521600
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33942969
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32979060
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32268919
75IGF1R_20145208_ChIP-Seq_DFB_Human1.30978980
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30268287
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.30213223
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30208744
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30080223
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.27564383
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26927971
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26286987
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25034077
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24796813
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.24321188
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.23648956
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23583570
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23459076
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23421256
90HTT_18923047_ChIP-ChIP_STHdh_Human1.22591161
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.21582902
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.21092235
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19468302
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.18998237
95P68_20966046_ChIP-Seq_HELA_Human1.18337573
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.17460240
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.17077443
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16220136
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16185838
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16089401
101* CTCF_27219007_Chip-Seq_Bcells_Human1.16041296
102EOMES_21245162_ChIP-Seq_HESCs_Human1.15843543
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.14374509
104* GATA4_25053715_ChIP-Seq_YYC3_Human1.14021532
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13397312
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13207013
107TP53_16413492_ChIP-PET_HCT116_Human1.11179001
108UBF1/2_26484160_Chip-Seq_HMECs_Human1.10702692
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09096010
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09096010
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09096010
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.08412224
113DROSHA_22980978_ChIP-Seq_HELA_Human1.08354824
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08008250
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07709627
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.07285420
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06223446
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05359180
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04740466
120* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04644966
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04624147
122SA1_27219007_Chip-Seq_ERYTHROID_Human1.02890411
123* NANOG_19829295_ChIP-Seq_ESCs_Human1.02701863
124* SOX2_19829295_ChIP-Seq_ESCs_Human1.02701863
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02642948
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02546079
127TP63_23658742_ChIP-Seq_EP156T_Human1.01139816
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00718896
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99769491
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.99038696
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.98954685
132CLOCK_20551151_ChIP-Seq_293T_Human0.98879559
133SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98873931
134STAT3_23295773_ChIP-Seq_U87_Human0.98146189
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97839634
136SMAD4_21741376_ChIP-Seq_EPCs_Human0.97779699
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.97605188
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97515873
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96980289
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96852645
141CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96223712
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96211516
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96167702
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95563146
145WT1_19549856_ChIP-ChIP_CCG9911_Human0.95521861
146BCOR_27268052_Chip-Seq_Bcells_Human0.94495509
147SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94252856
148* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94151237
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93722633
150CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93395896
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93211388
152GATA1_19941826_ChIP-Seq_K562_Human0.92649776
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92137129
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92087375
155* P300_19829295_ChIP-Seq_ESCs_Human0.91990324
156CTCF_20526341_ChIP-Seq_ESCs_Human0.91803725
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.90776979
158RARB_27405468_Chip-Seq_BRAIN_Mouse0.90117834
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90049314
160NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89902683
161TRIM28_21343339_ChIP-Seq_HEK293_Human0.89633085
162NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89452205
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89291633
164FOXH1_21741376_ChIP-Seq_ESCs_Human0.88673911
165ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88077964
166ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87893289
167JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87793631
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87774765
169GATA6_21074721_ChIP-Seq_CACO-2_Human0.87692170
170CREB1_26743006_Chip-Seq_LNCaP_Human0.87590143
171SA1_27219007_Chip-Seq_Bcells_Human0.87503837
172NANOG_18555785_Chip-Seq_ESCs_Mouse0.86453528
173AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86279656
174CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86096367
175BP1_19119308_ChIP-ChIP_Hs578T_Human0.85806340
176WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85765485
177RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85112380
178SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84502709
179GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84247386
180MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84184070
181PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84177584
182KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83641669
183OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83225756
184CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82933590
185NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82577248
186PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81786576
187FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81500771
188LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81317962

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.68909020
2MP0000920_abnormal_myelination5.32575980
3MP0003950_abnormal_plasma_membrane3.55316466
4MP0003329_amyloid_beta_deposits3.32767573
5MP0005377_hearing/vestibular/ear_phenot3.31385001
6MP0003878_abnormal_ear_physiology3.31385001
7MP0000579_abnormal_nail_morphology3.25227923
8MP0003690_abnormal_glial_cell3.17166318
9MP0010678_abnormal_skin_adnexa3.02825188
10MP0004264_abnormal_extraembryonic_tissu3.02703099
11MP0000383_abnormal_hair_follicle2.85384603
12MP0003880_abnormal_central_pattern2.83971398
13MP0001529_abnormal_vocalization2.53600734
14MP0002060_abnormal_skin_morphology2.48069187
15MP0005409_darkened_coat_color2.46160645
16MP0003941_abnormal_skin_development2.44908855
17MP0004885_abnormal_endolymph2.44417799
18MP0001905_abnormal_dopamine_level2.43625011
19MP0004270_analgesia2.37900779
20MP0010352_gastrointestinal_tract_polyps2.32756204
21MP0008260_abnormal_autophagy2.30193555
22MP0004742_abnormal_vestibular_system2.24586448
23MP0003566_abnormal_cell_adhesion2.23280763
24MP0002796_impaired_skin_barrier2.20278180
25MP0003634_abnormal_glial_cell2.13635263
26MP0003806_abnormal_nucleotide_metabolis2.11702409
27MP0003633_abnormal_nervous_system2.08806204
28MP0002272_abnormal_nervous_system2.07148364
29MP0005171_absent_coat_pigmentation2.05621557
30MP0000604_amyloidosis2.05398557
31MP0003656_abnormal_erythrocyte_physiolo2.00041828
32MP0003631_nervous_system_phenotype1.97919894
33MP0003632_abnormal_nervous_system1.94425237
34MP0000537_abnormal_urethra_morphology1.92988837
35MP0004142_abnormal_muscle_tone1.92256361
36MP0005423_abnormal_somatic_nervous1.88773103
37MP0000647_abnormal_sebaceous_gland1.84886279
38MP0005410_abnormal_fertilization1.82699748
39MP0001486_abnormal_startle_reflex1.81392902
40MP0005023_abnormal_wound_healing1.80473450
41MP0002064_seizures1.75309280
42MP0004043_abnormal_pH_regulation1.67774576
43MP0000467_abnormal_esophagus_morphology1.66983841
44MP0004381_abnormal_hair_follicle1.64434277
45MP0005501_abnormal_skin_physiology1.63236486
46MP0004134_abnormal_chest_morphology1.57430521
47MP0000778_abnormal_nervous_system1.57150375
48MP0003195_calcinosis1.54481301
49MP0005058_abnormal_lysosome_morphology1.53425253
50MP0000462_abnormal_digestive_system1.52190220
51MP0001485_abnormal_pinna_reflex1.50687914
52MP0002229_neurodegeneration1.50186244
53MP0009780_abnormal_chondrocyte_physiolo1.49016537
54MP0000762_abnormal_tongue_morphology1.45976144
55MP0005275_abnormal_skin_tensile1.42465686
56MP0008438_abnormal_cutaneous_collagen1.41874204
57MP0003705_abnormal_hypodermis_morpholog1.40096770
58MP0002877_abnormal_melanocyte_morpholog1.37737790
59MP0008875_abnormal_xenobiotic_pharmacok1.37662287
60MP0002234_abnormal_pharynx_morphology1.35949798
61MP0003453_abnormal_keratinocyte_physiol1.34746278
62MP0004782_abnormal_surfactant_physiolog1.33054568
63MP0004947_skin_inflammation1.30869396
64MP0002295_abnormal_pulmonary_circulatio1.30531698
65MP0009697_abnormal_copulation1.30176306
66MP0010030_abnormal_orbit_morphology1.27498363
67MP0001970_abnormal_pain_threshold1.24948482
68MP0000678_abnormal_parathyroid_gland1.22931042
69MP0000747_muscle_weakness1.20413812
70MP0009931_abnormal_skin_appearance1.19043140
71MP0000627_abnormal_mammary_gland1.18558909
72MP0010771_integument_phenotype1.18445747
73MP0008569_lethality_at_weaning1.16262306
74MP0001851_eye_inflammation1.14728329
75MP0001849_ear_inflammation1.14603493
76MP0009053_abnormal_anal_canal1.13587841
77MP0005623_abnormal_meninges_morphology1.09287582
78MP0003635_abnormal_synaptic_transmissio1.07714047
79MP0001177_atelectasis1.05816916
80MP0001191_abnormal_skin_condition1.05567611
81MP0002063_abnormal_learning/memory/cond1.03704529
82MP0004859_abnormal_synaptic_plasticity1.03422539
83MP0009745_abnormal_behavioral_response1.03338488
84MP0005551_abnormal_eye_electrophysiolog1.03236414
85MP0005451_abnormal_body_composition1.02243377
86MP0004036_abnormal_muscle_relaxation1.00798350
87MP0002734_abnormal_mechanical_nocicepti1.00425952
88MP0002572_abnormal_emotion/affect_behav1.00052908
89MP0003315_abnormal_perineum_morphology0.99050126
90MP0000367_abnormal_coat/_hair0.98607634
91MP0002066_abnormal_motor_capabilities/c0.96875899
92MP0004185_abnormal_adipocyte_glucose0.96627695
93MP0000955_abnormal_spinal_cord0.95325003
94MP0003075_altered_response_to0.94468213
95MP0003136_yellow_coat_color0.94098649
96MP0000749_muscle_degeneration0.92375351
97MP0002882_abnormal_neuron_morphology0.92190933
98MP0000377_abnormal_hair_follicle0.92152726
99MP0005076_abnormal_cell_differentiation0.91762876
100MP0002098_abnormal_vibrissa_morphology0.91627237
101MP0009840_abnormal_foam_cell0.91242752
102MP0000858_altered_metastatic_potential0.89295435
103MP0005388_respiratory_system_phenotype0.85576727
104MP0002133_abnormal_respiratory_system0.85576727
105MP0000427_abnormal_hair_cycle0.85389862
106MP0000003_abnormal_adipose_tissue0.83081291
107MP0001340_abnormal_eyelid_morphology0.82785881
108MP0001440_abnormal_grooming_behavior0.81077220
109MP0005195_abnormal_posterior_eye0.79925119
110MP0006054_spinal_hemorrhage0.78499737
111MP0009046_muscle_twitch0.78161322
112MP0003638_abnormal_response/metabolism_0.77897715
113MP0004858_abnormal_nervous_system0.77249151
114MP0001346_abnormal_lacrimal_gland0.76781338
115MP0004019_abnormal_vitamin_homeostasis0.76617531
116MP0003693_abnormal_embryo_hatching0.76059257
117MP0002733_abnormal_thermal_nociception0.73718203
118MP0000566_synostosis0.73545915
119MP0004233_abnormal_muscle_weight0.72094853
120MP0002067_abnormal_sensory_capabilities0.71238349
121MP0002118_abnormal_lipid_homeostasis0.71175289
122MP0001216_abnormal_epidermal_layer0.71155796
123MP0003011_delayed_dark_adaptation0.70919651
124MP0003186_abnormal_redox_activity0.68994158
125MP0006082_CNS_inflammation0.68838869
126MP0001243_abnormal_dermal_layer0.68755296
127MP0001299_abnormal_eye_distance/0.68751430
128MP0004272_abnormal_basement_membrane0.67294192
129MP0009250_abnormal_appendicular_skeleto0.67197667
130MP0004957_abnormal_blastocyst_morpholog0.66920703
131MP0004145_abnormal_muscle_electrophysio0.65711249
132MP0000465_gastrointestinal_hemorrhage0.65636449
133MP0001963_abnormal_hearing_physiology0.65536699
134MP0002752_abnormal_somatic_nervous0.65328495
135MP0003938_abnormal_ear_development0.60834840
136MP0002933_joint_inflammation0.60021248
137MP0002249_abnormal_larynx_morphology0.58821753
138MP0003191_abnormal_cellular_cholesterol0.58430590
139MP0002736_abnormal_nociception_after0.58198175
140MP0008932_abnormal_embryonic_tissue0.58149795
141MP0002090_abnormal_vision0.57687970
142MP0002111_abnormal_tail_morphology0.50466970
143MP0003786_premature_aging0.50442309
144MP0000516_abnormal_urinary_system0.50156337
145MP0005367_renal/urinary_system_phenotyp0.50156337
146MP0009672_abnormal_birth_weight0.49045680
147MP0005621_abnormal_cell_physiology0.48023889
148MP0005257_abnormal_intraocular_pressure0.47913894
149MP0001348_abnormal_lacrimal_gland0.47756261
150MP0001502_abnormal_circadian_rhythm0.47449107
151MP0003879_abnormal_hair_cell0.46070164
152MP0000358_abnormal_cell_content/0.45937489
153MP0001881_abnormal_mammary_gland0.45820349
154MP0001853_heart_inflammation0.43776344
155MP0000613_abnormal_salivary_gland0.43058892

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.65336919
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.65336919
3Neurofibrillary tangles (HP:0002185)6.46566106
4Onycholysis (HP:0001806)6.26916623
5Right ventricular cardiomyopathy (HP:0011663)5.57089164
6Termporal pattern (HP:0011008)5.29432345
7Insidious onset (HP:0003587)5.29432345
8Abnormality of the corticospinal tract (HP:0002492)5.08777048
9Alopecia of scalp (HP:0002293)4.97942543
10Cerebral inclusion bodies (HP:0100314)4.91835157
11Parakeratosis (HP:0001036)4.83953384
12Hypotrichosis (HP:0001006)4.82481607
13Plantar hyperkeratosis (HP:0007556)4.57432014
14Pili torti (HP:0003777)4.50860861
15Onion bulb formation (HP:0003383)4.25161893
16Palmoplantar hyperkeratosis (HP:0000972)4.15407791
17Segmental peripheral demyelination/remyelination (HP:0003481)4.12111470
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.92854303
19Peripheral hypomyelination (HP:0007182)3.90800416
20Palmar hyperkeratosis (HP:0010765)3.83997246
21Nail dystrophy (HP:0008404)3.77635773
22Supranuclear gaze palsy (HP:0000605)3.75202947
23Ankle clonus (HP:0011448)3.74660865
24Abnormality of glycolysis (HP:0004366)3.72567612
25Increased serum pyruvate (HP:0003542)3.72567612
26Hypokinesia (HP:0002375)3.55671012
27Selective tooth agenesis (HP:0001592)3.51923975
28Axonal loss (HP:0003447)3.51337687
29Sparse eyelashes (HP:0000653)3.47998161
30Cerebral hypomyelination (HP:0006808)3.47153215
31Congenital ichthyosiform erythroderma (HP:0007431)3.45723570
32Retinal dysplasia (HP:0007973)3.45274599
33Abnormal hair laboratory examination (HP:0003328)3.43124771
34Corneal erosion (HP:0200020)3.41612943
35Distal lower limb amyotrophy (HP:0008944)3.32353511
36Leukodystrophy (HP:0002415)3.24490922
37Trismus (HP:0000211)3.21514348
38Erythema (HP:0010783)3.20322328
39Truncus arteriosus (HP:0001660)3.12211018
40Slow saccadic eye movements (HP:0000514)3.09084171
41Hypophosphatemic rickets (HP:0004912)3.08613895
42Oral leukoplakia (HP:0002745)3.07808395
43Woolly hair (HP:0002224)3.03643570
44Increased IgE level (HP:0003212)3.02479241
45Milia (HP:0001056)3.02248791
46Spastic gait (HP:0002064)2.99352454
47Intention tremor (HP:0002080)2.98763659
48Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97921929
49Dysmetria (HP:0001310)2.93816329
50Abnormal large intestine physiology (HP:0012700)2.92993020
51Lower limb amyotrophy (HP:0007210)2.83572314
52Hyperthyroidism (HP:0000836)2.81811566
53Abnormal blistering of the skin (HP:0008066)2.70126011
54Ridged nail (HP:0001807)2.69998760
55Scanning speech (HP:0002168)2.68849455
56Distal upper limb amyotrophy (HP:0007149)2.67169609
57Upper limb amyotrophy (HP:0009129)2.67169609
58Micronodular cirrhosis (HP:0001413)2.66570433
59Action tremor (HP:0002345)2.62429478
60Abnormality of nail color (HP:0100643)2.59945604
61Spastic tetraparesis (HP:0001285)2.59537628
62Abnormal auditory evoked potentials (HP:0006958)2.58354200
63Abnormality of the salivary glands (HP:0010286)2.56535184
64Cerebral hemorrhage (HP:0001342)2.55670710
65Absent eyelashes (HP:0000561)2.53713227
66Sensory axonal neuropathy (HP:0003390)2.52799211
67Abnormality of placental membranes (HP:0011409)2.52014966
68Amniotic constriction ring (HP:0009775)2.52014966
69Pustule (HP:0200039)2.51482363
70Ankyloglossia (HP:0010296)2.48713139
71Palmoplantar keratoderma (HP:0000982)2.48421979
72Stridor (HP:0010307)2.48343245
73Erythroderma (HP:0001019)2.47371375
74Anteriorly placed anus (HP:0001545)2.42428343
75CNS hypomyelination (HP:0003429)2.40740242
76Urinary urgency (HP:0000012)2.39037573
77Ectropion (HP:0000656)2.37822119
78Pheochromocytoma (HP:0002666)2.34441066
79Increased circulating renin level (HP:0000848)2.32250797
80Hammertoe (HP:0001765)2.31920286
81Enlarged epiphyses (HP:0010580)2.30170188
82Clonus (HP:0002169)2.29677647
83Pterygium (HP:0001059)2.27104780
84Morphological abnormality of the inner ear (HP:0011390)2.26293229
85Hypoplasia of the iris (HP:0007676)2.25962564
86Hypohidrosis (HP:0000966)2.25046902
87Difficulty walking (HP:0002355)2.24776496
88Hyporeflexia of lower limbs (HP:0002600)2.21380874
89Foot dorsiflexor weakness (HP:0009027)2.20701720
90Thick nail (HP:0001805)2.20647913
91Acute encephalopathy (HP:0006846)2.19286664
92Hypoplastic labia majora (HP:0000059)2.18388037
93Amelogenesis imperfecta (HP:0000705)2.17971907
94Acanthosis nigricans (HP:0000956)2.17917993
95Atrophic scars (HP:0001075)2.17619049
96Coronal craniosynostosis (HP:0004440)2.17570185
97Abnormality of the distal phalanges of the toes (HP:0010182)2.17525527
98Lower limb muscle weakness (HP:0007340)2.16221015
99Loss of speech (HP:0002371)2.15675027
100Distal lower limb muscle weakness (HP:0009053)2.15456083
101Seborrheic dermatitis (HP:0001051)2.14638177
102Metabolic alkalosis (HP:0200114)2.11865542
103Decreased motor nerve conduction velocity (HP:0003431)2.11294780
104Popliteal pterygium (HP:0009756)2.10797938
105Hypoplastic pelvis (HP:0008839)2.10683179
106Acute necrotizing encephalopathy (HP:0006965)2.09645620
107Short nail (HP:0001799)2.07728349
108Ulnar claw (HP:0001178)2.06844260
109Autoamputation (HP:0001218)2.06220740
110Broad face (HP:0000283)2.03978569
111Hepatosplenomegaly (HP:0001433)2.03798573
112Abnormality of the foot musculature (HP:0001436)2.03422641
113Neuroendocrine neoplasm (HP:0100634)2.02993506
114Absent septum pellucidum (HP:0001331)2.01550753
115Diminished movement (HP:0002374)2.00701053
116Diaphragmatic weakness (HP:0009113)2.00340533
117Peripheral demyelination (HP:0011096)1.99495080
118Aplasia involving bones of the extremities (HP:0009825)1.99492706
119Aplasia involving bones of the upper limbs (HP:0009823)1.99492706
120Aplasia of the phalanges of the hand (HP:0009802)1.99492706
121Clumsiness (HP:0002312)1.98383579
122Ventricular tachycardia (HP:0004756)1.98219842
123Esophageal atresia (HP:0002032)1.97346964
124Hypokalemic alkalosis (HP:0001949)1.96920216
125Methylmalonic acidemia (HP:0002912)1.96076625
126Hypoplasia of dental enamel (HP:0006297)1.95920184
127Type II lissencephaly (HP:0007260)1.95793508
128Abnormality of permanent molar morphology (HP:0011071)1.95777080
129Abnormality of the dental root (HP:0006486)1.95777080
130Taurodontia (HP:0000679)1.95777080
131Alacrima (HP:0000522)1.95726465
132Apathy (HP:0000741)1.95446384
133Neuronal loss in central nervous system (HP:0002529)1.94017960
134Lip pit (HP:0100267)1.93993554
135Akinesia (HP:0002304)1.93906111
136Morphological abnormality of the pyramidal tract (HP:0002062)1.92847575
137Reduced subcutaneous adipose tissue (HP:0003758)1.92383989
138Steppage gait (HP:0003376)1.92133284
139Abnormality of the labia majora (HP:0012881)1.91236522
140Achilles tendon contracture (HP:0001771)1.90837893
141Spastic paraparesis (HP:0002313)1.90760093
142Buphthalmos (HP:0000557)1.90644932
143Vascular calcification (HP:0004934)1.89898534
144Muscle fiber splitting (HP:0003555)1.89874273
145Paraparesis (HP:0002385)1.86110335
146Postnatal microcephaly (HP:0005484)1.85769935
147Urinary incontinence (HP:0000020)1.85727078
148Brittle hair (HP:0002299)1.84594784
149Difficulty running (HP:0009046)1.83379380
150Distal sensory impairment (HP:0002936)1.80096472
151Hyperacusis (HP:0010780)1.79626983
152Anomalous pulmonary venous return (HP:0010772)1.79188485
153Postural tremor (HP:0002174)1.78628601
154Sparse scalp hair (HP:0002209)1.78444444
155Fragile nails (HP:0001808)1.78145785
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77253631
157Aplasia cutis congenita (HP:0001057)1.75784262
158Abnormality of oral frenula (HP:0000190)1.75363188
159Diminished motivation (HP:0000745)1.75172719
160Advanced eruption of teeth (HP:0006288)1.74888569
161Abnormality of the Achilles tendon (HP:0005109)1.74015770
162Abnormality of molar (HP:0011077)1.74001979
163Abnormality of molar morphology (HP:0011070)1.74001979
164Bowel incontinence (HP:0002607)1.73807756
165Patchy hypopigmentation of hair (HP:0011365)1.73772475
166Hyperlipoproteinemia (HP:0010980)1.72636585
167Fragile skin (HP:0001030)1.72108825
168Abnormality of the axillary hair (HP:0100134)1.72008904
169Abnormality of secondary sexual hair (HP:0009888)1.72008904
170Progressive macrocephaly (HP:0004481)1.71517263
171Megalencephaly (HP:0001355)1.70552997
172Choreoathetosis (HP:0001266)1.70121907
173Myokymia (HP:0002411)1.69851271
174Abnormality of the septum pellucidum (HP:0007375)1.69735441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.98360679
2STK396.33259999
3MST1R6.01420966
4MAPKAPK55.61296734
5EPHB15.13014074
6PBK3.60486083
7MAP3K123.35061307
8OXSR13.13154501
9WNK43.00729272
10LMTK22.60511293
11TESK22.41453524
12PKN12.39301694
13IRAK32.36188548
14SIK12.24636136
15FGFR22.23114527
16UHMK12.14616146
17PAK42.11978524
18MAP3K92.10776026
19MST41.99969546
20NME11.98178833
21PTK21.97542367
22WNK11.88376031
23MKNK11.87199238
24BCR1.86559690
25LATS21.82357279
26SGK2231.81963446
27SGK4941.81963446
28MET1.81663940
29MAP3K31.64952534
30CLK11.53736259
31LIMK11.51019784
32NME21.49380680
33PNCK1.48867935
34TESK11.44275634
35EPHB21.37174707
36ARAF1.34962802
37FGR1.30310051
38CAMK2B1.29819595
39RPS6KA51.26427301
40DYRK21.25614930
41ROCK21.23405573
42NTRK11.21628549
43PRKD11.20800001
44EIF2AK11.19891945
45CSNK1G31.19139644
46CSNK1A1L1.14901302
47GRK71.14298853
48EPHA41.12771744
49LATS11.12178661
50RPS6KB21.11977430
51MARK21.11711099
52SMG11.11637534
53FLT31.10034086
54DAPK11.06798019
55STK381.05659165
56CAMK2D1.05612459
57MYLK1.02106681
58CDK80.99056683
59ABL20.95975712
60PRKD30.95138083
61IRAK20.94855595
62RIPK10.92325001
63CASK0.90253861
64ILK0.87279214
65CSNK1G10.87046720
66SCYL20.87033017
67NTRK30.86866900
68GSK3A0.86027505
69MAP2K20.83723403
70CAMK2G0.80471365
71MARK10.79846479
72EPHA30.79501981
73CAMK2A0.79474851
74PRKCE0.78272931
75CSNK1G20.77308114
76BRSK10.76818446
77TYRO30.73080041
78DDR20.70543641
79PRKCQ0.69979175
80PAK60.68774628
81PDGFRA0.67650319
82PRKCI0.67288366
83MAP3K10.66683221
84ADRBK20.65535501
85MINK10.64978818
86SIK30.64871514
87CDK140.62925137
88MAPK150.61516077
89KSR10.61322748
90MAP3K20.59063392
91NTRK20.57939248
92BLK0.57893982
93CDK190.57716291
94CDK50.57569029
95PINK10.56563087
96MAP2K60.55588931
97CDK150.55238476
98CDK90.54675385
99MAPK40.54063920
100BMPR1B0.52920937
101PRKG20.50628783
102MAPK120.50521177
103PHKG10.50093787
104PHKG20.50093787
105ERN10.50044434
106CDK180.49414297
107PAK30.48173985
108FYN0.48154635
109MAPKAPK20.47787574
110PRKG10.47374140
111BUB10.46765967
112CDK11A0.46622426
113CSNK1D0.45274250
114NEK60.44879655
115PRKACB0.43384540
116FER0.42890491
117PDPK10.41383477
118ICK0.41355864
119STK38L0.41099574
120CSNK1A10.41004839
121MUSK0.40577014
122GRK50.40289185
123CAMK1G0.39737027
124MAP2K10.39425627
125BMX0.39061220
126AURKB0.37193551
127VRK20.36137982
128NEK10.35779277
129OBSCN0.35552842
130MAPK130.34587829
131PTK60.33626974
132PLK20.33095677
133MAP3K80.32955934
134PRKACA0.32613052
135MELK0.32495311
136IRAK10.31870095
137PIK3CA0.31860342
138HIPK20.30555840
139KSR20.29996631
140GRK10.29419927
141ERBB20.29389591
142PRKD20.29260857
143AURKA0.28497097
144CAMK10.26721485
145ERBB40.25415069
146PAK20.25283499
147STK110.25162797
148INSR0.24467971
149SRC0.24116062
150DMPK0.23592937
151PAK10.23405587
152PRKCA0.23142215
153RET0.22434441
154DYRK1A0.22129179
155RAF10.21921286
156BCKDK0.21632797
157RPS6KA40.21551041
158DAPK30.21481307
159TIE10.21387140
160TTK0.19604395
161CDK70.19283124
162EIF2AK20.18651951
163ZAP700.18627613
164CDK120.17673705
165BRAF0.17669393
166STK100.17664948
167LRRK20.16164959

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009006.45325120
2Fatty acid elongation_Homo sapiens_hsa000625.74057631
3Proteasome_Homo sapiens_hsa030505.45198162
4Steroid biosynthesis_Homo sapiens_hsa001005.42285178
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.71565210
6Ether lipid metabolism_Homo sapiens_hsa005653.43559686
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32910810
8Histidine metabolism_Homo sapiens_hsa003402.31092336
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23478858
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17448301
11Nitrogen metabolism_Homo sapiens_hsa009102.14968772
12Phenylalanine metabolism_Homo sapiens_hsa003602.08088724
13Linoleic acid metabolism_Homo sapiens_hsa005912.02431716
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98034219
15Thyroid cancer_Homo sapiens_hsa052161.91746022
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89378174
17Sulfur metabolism_Homo sapiens_hsa009201.88277727
18Vitamin B6 metabolism_Homo sapiens_hsa007501.83548135
19Galactose metabolism_Homo sapiens_hsa000521.83445492
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.82861546
21Mismatch repair_Homo sapiens_hsa034301.80571708
22Synaptic vesicle cycle_Homo sapiens_hsa047211.79499883
23Protein export_Homo sapiens_hsa030601.57896176
24Butanoate metabolism_Homo sapiens_hsa006501.56240406
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50429842
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.47658096
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37252811
28Sulfur relay system_Homo sapiens_hsa041221.36975476
29Oxidative phosphorylation_Homo sapiens_hsa001901.34413514
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32278805
31Adherens junction_Homo sapiens_hsa045201.31390385
32Sphingolipid metabolism_Homo sapiens_hsa006001.28692591
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28017598
34Fatty acid metabolism_Homo sapiens_hsa012121.27464589
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24921112
36Fructose and mannose metabolism_Homo sapiens_hsa000511.20636814
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.19423466
38Pentose phosphate pathway_Homo sapiens_hsa000301.19144259
39Biosynthesis of amino acids_Homo sapiens_hsa012301.16415936
40Long-term potentiation_Homo sapiens_hsa047201.15647909
41DNA replication_Homo sapiens_hsa030301.15414603
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11469906
43Parkinsons disease_Homo sapiens_hsa050121.09061018
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07086509
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05201242
46Arginine and proline metabolism_Homo sapiens_hsa003301.04862970
47Alzheimers disease_Homo sapiens_hsa050101.04637699
48Propanoate metabolism_Homo sapiens_hsa006401.03922688
49N-Glycan biosynthesis_Homo sapiens_hsa005101.01831490
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97855190
51Glioma_Homo sapiens_hsa052140.95686327
52Hippo signaling pathway_Homo sapiens_hsa043900.93068097
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90281240
54Other glycan degradation_Homo sapiens_hsa005110.89941724
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87515238
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86446547
57Carbon metabolism_Homo sapiens_hsa012000.86106088
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85631460
59Glutamatergic synapse_Homo sapiens_hsa047240.85601586
60Serotonergic synapse_Homo sapiens_hsa047260.84403320
61Pancreatic cancer_Homo sapiens_hsa052120.82756341
62GABAergic synapse_Homo sapiens_hsa047270.82596269
63Axon guidance_Homo sapiens_hsa043600.82530688
64GnRH signaling pathway_Homo sapiens_hsa049120.82514885
65Oocyte meiosis_Homo sapiens_hsa041140.82165180
66Glutathione metabolism_Homo sapiens_hsa004800.81537177
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.79649856
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.78774409
69Long-term depression_Homo sapiens_hsa047300.77472774
70ErbB signaling pathway_Homo sapiens_hsa040120.76980157
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76438801
72Shigellosis_Homo sapiens_hsa051310.75308043
73Pyruvate metabolism_Homo sapiens_hsa006200.74423345
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73726374
75Chemical carcinogenesis_Homo sapiens_hsa052040.73670254
76Arachidonic acid metabolism_Homo sapiens_hsa005900.73608193
77Mineral absorption_Homo sapiens_hsa049780.73168860
78Base excision repair_Homo sapiens_hsa034100.71898125
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71669562
80Renal cell carcinoma_Homo sapiens_hsa052110.70002233
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69753856
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.69729089
83Chronic myeloid leukemia_Homo sapiens_hsa052200.69363425
84Bladder cancer_Homo sapiens_hsa052190.65789717
85Small cell lung cancer_Homo sapiens_hsa052220.65674198
86Focal adhesion_Homo sapiens_hsa045100.64542997
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.64417823
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64362353
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.63847246
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62505061
91Peroxisome_Homo sapiens_hsa041460.62210802
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62177368
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61807556
94Salmonella infection_Homo sapiens_hsa051320.60537575
95Bile secretion_Homo sapiens_hsa049760.55341485
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.55332245
97Collecting duct acid secretion_Homo sapiens_hsa049660.55212705
98Proteoglycans in cancer_Homo sapiens_hsa052050.55151828
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54570082
100Tight junction_Homo sapiens_hsa045300.54153136
101Lysosome_Homo sapiens_hsa041420.53624953
102Starch and sucrose metabolism_Homo sapiens_hsa005000.53590728
103Amphetamine addiction_Homo sapiens_hsa050310.52911833
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52350824
105Ovarian steroidogenesis_Homo sapiens_hsa049130.51276666
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50935513
107Melanogenesis_Homo sapiens_hsa049160.50816070
108Gastric acid secretion_Homo sapiens_hsa049710.50678007
109Vitamin digestion and absorption_Homo sapiens_hsa049770.50231348
110Ras signaling pathway_Homo sapiens_hsa040140.49725889
111Cell cycle_Homo sapiens_hsa041100.49532753
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49446245
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49277633
114Cocaine addiction_Homo sapiens_hsa050300.49248006
115beta-Alanine metabolism_Homo sapiens_hsa004100.49224819
116Vibrio cholerae infection_Homo sapiens_hsa051100.49159581
117VEGF signaling pathway_Homo sapiens_hsa043700.49052922
118Estrogen signaling pathway_Homo sapiens_hsa049150.48775245
119Insulin signaling pathway_Homo sapiens_hsa049100.48754429
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47966092
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46963850
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45789787
123Phagosome_Homo sapiens_hsa041450.44483427
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.42236142
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42223813
126Dorso-ventral axis formation_Homo sapiens_hsa043200.41787588
127Morphine addiction_Homo sapiens_hsa050320.41529399
128Circadian entrainment_Homo sapiens_hsa047130.40782569
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40571555
130Endocytosis_Homo sapiens_hsa041440.40350848
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.39815347
132Tyrosine metabolism_Homo sapiens_hsa003500.39359123
133Pyrimidine metabolism_Homo sapiens_hsa002400.38862961
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.38533747
135Folate biosynthesis_Homo sapiens_hsa007900.37948968
136Renin secretion_Homo sapiens_hsa049240.37777699
137Metabolic pathways_Homo sapiens_hsa011000.37667269
138Pancreatic secretion_Homo sapiens_hsa049720.36798911
139Dopaminergic synapse_Homo sapiens_hsa047280.35780428
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35277090
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33383750
142Cardiac muscle contraction_Homo sapiens_hsa042600.33164011
143Arginine biosynthesis_Homo sapiens_hsa002200.32382301
144Salivary secretion_Homo sapiens_hsa049700.31669335
145Fat digestion and absorption_Homo sapiens_hsa049750.31197070
146Rheumatoid arthritis_Homo sapiens_hsa053230.30775172
147Huntingtons disease_Homo sapiens_hsa050160.30183980
148ABC transporters_Homo sapiens_hsa020100.28880269
149Retinol metabolism_Homo sapiens_hsa008300.27513924
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.26979625
151Prion diseases_Homo sapiens_hsa050200.26933425
152Cholinergic synapse_Homo sapiens_hsa047250.26906546
153Fatty acid biosynthesis_Homo sapiens_hsa000610.26378036
154PPAR signaling pathway_Homo sapiens_hsa033200.25801307
155ECM-receptor interaction_Homo sapiens_hsa045120.25354107
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24548055
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23978160
158Gap junction_Homo sapiens_hsa045400.23738099
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22863417
160Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20040468
161Glycerolipid metabolism_Homo sapiens_hsa005610.18447347
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.17789105
163Fatty acid degradation_Homo sapiens_hsa000710.16590380

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