KLK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water homeostasis (GO:0030104)8.58653514
2keratinocyte differentiation (GO:0030216)7.91350864
3peptide cross-linking (GO:0018149)7.84826582
4detection of bacterium (GO:0016045)7.69515117
5regulation of transforming growth factor beta1 production (GO:0032908)6.83914011
6intermediate filament organization (GO:0045109)6.64336183
7detection of other organism (GO:0098543)6.61559733
8sphingoid metabolic process (GO:0046519)6.58380769
9positive regulation of glomerulus development (GO:0090193)6.56304765
10epidermal cell differentiation (GO:0009913)6.55066737
11skin morphogenesis (GO:0043589)6.33368092
12regulation of cell proliferation involved in kidney development (GO:1901722)5.86636966
13fatty acid elongation (GO:0030497)5.78703402
14hemidesmosome assembly (GO:0031581)5.76974178
15long-chain fatty acid biosynthetic process (GO:0042759)5.63487993
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.54420775
17* epidermis development (GO:0008544)5.49709803
18gap junction assembly (GO:0016264)5.48649324
19regulation of ruffle assembly (GO:1900027)5.38375632
20keratinocyte proliferation (GO:0043616)5.13300885
21sphingosine metabolic process (GO:0006670)5.08697190
22chemical homeostasis within a tissue (GO:0048875)4.98565826
23diol metabolic process (GO:0034311)4.91180407
24surfactant homeostasis (GO:0043129)4.82645235
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.82338622
26regulation of glomerulus development (GO:0090192)4.58896433
27regulation of natural killer cell differentiation (GO:0032823)4.57972742
28ectoderm development (GO:0007398)4.47508991
29intermediate filament cytoskeleton organization (GO:0045104)4.37549515
30regulation of keratinocyte proliferation (GO:0010837)4.33027061
31intermediate filament-based process (GO:0045103)4.30029768
32phospholipid efflux (GO:0033700)4.28525034
33positive regulation of epidermal cell differentiation (GO:0045606)4.21370914
34positive regulation of interleukin-8 secretion (GO:2000484)4.17890594
35polarized epithelial cell differentiation (GO:0030859)4.10610064
36linoleic acid metabolic process (GO:0043651)4.09956562
37positive regulation of transforming growth factor beta production (GO:0071636)4.08408358
38positive regulation of cholesterol efflux (GO:0010875)3.95084976
39phospholipid scrambling (GO:0017121)3.92764148
40regulation of keratinocyte differentiation (GO:0045616)3.79650128
41hormone catabolic process (GO:0042447)3.72681151
42intestinal epithelial cell development (GO:0060576)3.69309256
43lipoxygenase pathway (GO:0019372)3.65619271
44phosphatidylserine metabolic process (GO:0006658)3.64007370
45lateral sprouting from an epithelium (GO:0060601)3.54870167
46positive regulation of cholesterol transport (GO:0032376)3.53308524
47positive regulation of sterol transport (GO:0032373)3.53308524
48positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.51867892
49detection of external biotic stimulus (GO:0098581)3.48323730
50hair follicle morphogenesis (GO:0031069)3.47649245
51ventricular cardiac muscle cell action potential (GO:0086005)3.47555704
52regulation of epidermis development (GO:0045682)3.45161318
53positive regulation of monocyte chemotaxis (GO:0090026)3.44118025
54phosphatidylinositol acyl-chain remodeling (GO:0036149)3.38384650
55positive regulation of hair cycle (GO:0042635)3.34819495
56positive regulation of hair follicle development (GO:0051798)3.34819495
57ceramide biosynthetic process (GO:0046513)3.30586353
58keratinocyte development (GO:0003334)3.29381014
59long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26226005
60regulation of heart rate by cardiac conduction (GO:0086091)3.21765087
61positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.20154231
62negative regulation of interferon-gamma production (GO:0032689)3.17064993
63negative regulation of stress fiber assembly (GO:0051497)3.16706352
64regulation of epidermal cell differentiation (GO:0045604)3.15778701
65cell-substrate junction assembly (GO:0007044)3.15079887
66sphingolipid biosynthetic process (GO:0030148)3.14643364
67adhesion of symbiont to host cell (GO:0044650)3.07912123
68virion attachment to host cell (GO:0019062)3.07912123
69regulation of transforming growth factor beta production (GO:0071634)3.07353659
70regulation of phospholipase A2 activity (GO:0032429)3.00559430
71negative regulation of epidermis development (GO:0045683)2.99457690
72positive regulation of keratinocyte differentiation (GO:0045618)2.99355759
73glucosamine-containing compound catabolic process (GO:1901072)2.99132614
74negative regulation of keratinocyte proliferation (GO:0010839)2.98138736
75response to phenylpropanoid (GO:0080184)2.97610535
76phosphatidylserine acyl-chain remodeling (GO:0036150)2.97239812
77negative regulation of interleukin-17 production (GO:0032700)2.94690078
78regulation of T cell chemotaxis (GO:0010819)2.94235138
79positive regulation of T cell chemotaxis (GO:0010820)2.94235138
80phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.93383065
81regulation of interleukin-8 secretion (GO:2000482)2.92771995
82sequestering of metal ion (GO:0051238)2.91391259
83eyelid development in camera-type eye (GO:0061029)2.90899985
84phospholipid catabolic process (GO:0009395)2.90835576
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.90623302
86alditol phosphate metabolic process (GO:0052646)2.90028344
87detection of biotic stimulus (GO:0009595)2.89669268
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81879306
89G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.81707224
90regulation of protein localization to cell surface (GO:2000008)2.81601712
91negative regulation of cell fate specification (GO:0009996)2.80513808
92regulation of cholesterol efflux (GO:0010874)2.78850388
93molting cycle process (GO:0022404)2.78599834
94hair cycle process (GO:0022405)2.78599834
95epithelial cell differentiation involved in prostate gland development (GO:0060742)2.78122390
96phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.76917038
97cell communication involved in cardiac conduction (GO:0086065)2.75965620
98peptide catabolic process (GO:0043171)2.75361218
99regulation of hair follicle development (GO:0051797)2.70871536
100cyclooxygenase pathway (GO:0019371)2.70240881
101phosphatidylcholine acyl-chain remodeling (GO:0036151)2.69980787
102skin development (GO:0043588)2.69350319
103regulation of hair cycle (GO:0042634)2.66598953
104epithelial cell proliferation (GO:0050673)2.65939241
105fatty-acyl-CoA metabolic process (GO:0035337)2.65158766
106regulation of neuron projection regeneration (GO:0070570)2.64020025
107regulation of axon regeneration (GO:0048679)2.64020025
108establishment of planar polarity (GO:0001736)2.63973222
109establishment of tissue polarity (GO:0007164)2.63973222
110positive regulation of epidermis development (GO:0045684)2.63608448
111very long-chain fatty acid metabolic process (GO:0000038)2.62456940
112fatty-acyl-CoA biosynthetic process (GO:0046949)2.60248953
113positive regulation of Cdc42 GTPase activity (GO:0043089)2.55931488
114cardiac conduction (GO:0061337)2.55909208
115* epithelium development (GO:0060429)2.55116589
116cell-cell junction assembly (GO:0007043)2.54060375
117epithelial cell differentiation (GO:0030855)2.54054447
118positive regulation of collagen biosynthetic process (GO:0032967)2.51584234
119beta-amyloid metabolic process (GO:0050435)2.49218602
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49116059
121defense response to fungus (GO:0050832)2.48550279
122negative regulation of epidermal cell differentiation (GO:0045605)2.47395996
123purinergic nucleotide receptor signaling pathway (GO:0035590)2.44566470
124cardiac muscle cell action potential involved in contraction (GO:0086002)2.43449177
125antimicrobial humoral response (GO:0019730)2.41589530
126positive regulation of cellular amide metabolic process (GO:0034250)2.40819613
127positive regulation of collagen metabolic process (GO:0010714)2.40721128
128magnesium ion transport (GO:0015693)2.40475927
129retinol metabolic process (GO:0042572)2.39094528
130adhesion of symbiont to host (GO:0044406)2.37225581
131morphogenesis of embryonic epithelium (GO:0016331)2.36347457
132cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.35922947
133transepithelial transport (GO:0070633)2.33231254
134regulation of transforming growth factor beta2 production (GO:0032909)2.33093501
135copper ion transport (GO:0006825)2.32702673
136establishment of skin barrier (GO:0061436)18.0970412
137regulation of water loss via skin (GO:0033561)15.8756143
138keratinization (GO:0031424)15.4784617
139desmosome organization (GO:0002934)12.6467366
140molting cycle (GO:0042303)11.1449054
141hair cycle (GO:0042633)11.1449054
142multicellular organismal water homeostasis (GO:0050891)10.3539014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.93787555
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.36730104
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.95125031
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.73413873
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.66783020
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.60456023
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.13298256
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.13217116
9FOXO3_23340844_ChIP-Seq_DLD1_Human2.12903708
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08865364
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08865364
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.07119454
13TP63_17297297_ChIP-ChIP_HaCaT_Human12.4139437
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84152522
15TP53_18474530_ChIP-ChIP_U2OS_Human1.79470323
16TP63_23658742_ChIP-Seq_EP156T_Human1.70520691
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67277565
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.66433626
19SOX2_20726797_ChIP-Seq_SW620_Human1.65467797
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58830764
21ZNF263_19887448_ChIP-Seq_K562_Human1.57461545
22GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.55949913
23GATA1_22025678_ChIP-Seq_K562_Human1.54250052
24GATA3_24758297_ChIP-Seq_MCF-7_Human1.50346104
25BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.47128994
26GATA6_21074721_ChIP-Seq_CACO-2_Human1.36849439
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36262835
28CJUN_26792858_Chip-Seq_BT549_Human1.34973479
29RXR_22108803_ChIP-Seq_LS180_Human1.32410485
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30727914
31ATF3_27146783_Chip-Seq_COLON_Human1.30612864
32TP63_22573176_ChIP-Seq_HFKS_Human1.30380461
33KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30203697
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29814300
35GATA4_25053715_ChIP-Seq_YYC3_Human1.28850823
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.26690977
37AR_21572438_ChIP-Seq_LNCaP_Human1.23962370
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18909115
39KLF5_25053715_ChIP-Seq_YYC3_Human1.16855199
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15479532
41CEBPB_22108803_ChIP-Seq_LS180_Human1.15004159
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12814636
43RACK7_27058665_Chip-Seq_MCF-7_Human1.10240308
44BCAT_22108803_ChIP-Seq_LS180_Human1.08758085
45UBF1/2_26484160_Chip-Seq_HMECs_Human1.07452281
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05544311
47CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04361762
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04258669
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02042010
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.01765839
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01652334
52RBPJ_21746931_ChIP-Seq_IB4_Human1.01251471
53CDX2_20551321_ChIP-Seq_CACO-2_Human0.99120888
54SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98824142
55VDR_22108803_ChIP-Seq_LS180_Human0.98675352
56TP53_20018659_ChIP-ChIP_R1E_Mouse0.98448790
57TCF4_22108803_ChIP-Seq_LS180_Human0.97659905
58CTCF_27219007_Chip-Seq_Bcells_Human0.97494794
59DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97115404
60LXR_22292898_ChIP-Seq_THP-1_Human0.94848840
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94686470
62P53_21459846_ChIP-Seq_SAOS-2_Human0.93207276
63EGR1_19032775_ChIP-ChIP_M12_Human0.92875398
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92695886
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92601901
66STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91457301
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91248259
68HNFA_21074721_ChIP-Seq_CACO-2_Human0.90944273
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90939230
70ARNT_22903824_ChIP-Seq_MCF-7_Human0.90814834
71AHR_22903824_ChIP-Seq_MCF-7_Human0.90450757
72PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90287922
73EED_16625203_ChIP-ChIP_MESCs_Mouse0.89191921
74EZH2_27304074_Chip-Seq_ESCs_Mouse0.89101964
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88723421
76SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88466481
77CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87810266
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87173636
79CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86768822
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86070651
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85843026
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85351790
83HTT_18923047_ChIP-ChIP_STHdh_Human0.84559401
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83492012
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82653044
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82550083
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.82164116
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81399050
89* ERG_20517297_ChIP-Seq_VCAP_Human0.80871607
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80810458
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80797397
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80650810
93SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80442807
94CTCF_20526341_ChIP-Seq_ESCs_Human0.80313501
95TAF2_19829295_ChIP-Seq_ESCs_Human0.80194218
96GATA6_25053715_ChIP-Seq_YYC3_Human0.79880625
97NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79610294
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79610294
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79408850
100TP53_16413492_ChIP-PET_HCT116_Human0.78750680
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.78471165
102EZH2_27294783_Chip-Seq_ESCs_Mouse0.77414983
103BCOR_27268052_Chip-Seq_Bcells_Human0.74913213
104E2F1_20622854_ChIP-Seq_HELA_Human0.74715615
105RNF2_27304074_Chip-Seq_ESCs_Mouse0.74435567
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74068662
107CDX2_22108803_ChIP-Seq_LS180_Human0.73527683
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72982317
109CLOCK_20551151_ChIP-Seq_293T_Human0.72598500
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.72566946
111OCT1_27270436_Chip-Seq_PROSTATE_Human0.72228212
112NANOG_20526341_ChIP-Seq_ESCs_Human0.71813042
113SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.71162160
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70755203
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.70686481
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.70686481
117BMI1_23680149_ChIP-Seq_NPCS_Mouse0.70576577
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69141936
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.69095702
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68977520
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.67146061
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.66402687
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.65770628
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62934501
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.61318250
126GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.60863543
127NCOR_22424771_ChIP-Seq_293T_Human0.59204135
128PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.56477886
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56408306
130ETV1_20927104_ChIP-Seq_GIST48_Human0.54779348
131PIAS1_25552417_ChIP-Seq_VCAP_Human0.54143179
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.53722418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.69532343
2MP0010234_abnormal_vibrissa_follicle6.07928501
3MP0005275_abnormal_skin_tensile5.82586258
4MP0003941_abnormal_skin_development5.51402275
5MP0005501_abnormal_skin_physiology5.31138568
6MP0005451_abnormal_body_composition5.30968875
7MP0000579_abnormal_nail_morphology4.32002485
8MP0004381_abnormal_hair_follicle3.94702238
9MP0002060_abnormal_skin_morphology3.35276645
10MP0001216_abnormal_epidermal_layer3.25739309
11MP0004947_skin_inflammation3.18240583
12MP0010771_integument_phenotype3.11421221
13MP0010678_abnormal_skin_adnexa2.80455840
14MP0000647_abnormal_sebaceous_gland2.79800628
15MP0002098_abnormal_vibrissa_morphology2.78674166
16MP0003191_abnormal_cellular_cholesterol2.56001489
17MP0000377_abnormal_hair_follicle2.44223659
18MP0003453_abnormal_keratinocyte_physiol2.43505155
19MP0004885_abnormal_endolymph2.26178017
20MP0000383_abnormal_hair_follicle2.25180099
21MP0000427_abnormal_hair_cycle2.20411346
22MP0003705_abnormal_hypodermis_morpholog2.13436354
23MP0002254_reproductive_system_inflammat2.05763345
24MP0000467_abnormal_esophagus_morphology2.05650276
25MP0000762_abnormal_tongue_morphology1.74876171
26MP0002009_preneoplasia1.71041580
27MP0009931_abnormal_skin_appearance1.70735212
28MP0005377_hearing/vestibular/ear_phenot1.68631782
29MP0003878_abnormal_ear_physiology1.68631782
30MP0004185_abnormal_adipocyte_glucose1.60705457
31MP0001191_abnormal_skin_condition1.59394402
32MP0004782_abnormal_surfactant_physiolog1.48760352
33MP0001243_abnormal_dermal_layer1.36347836
34MP0000367_abnormal_coat/_hair1.34246710
35MP0003566_abnormal_cell_adhesion1.29079263
36MP0003950_abnormal_plasma_membrane1.00850089
37MP0000465_gastrointestinal_hemorrhage0.96072621
38MP0003011_delayed_dark_adaptation0.94150488
39MP0001851_eye_inflammation0.87420487
40MP0002234_abnormal_pharynx_morphology0.86722421
41MP0001346_abnormal_lacrimal_gland0.86669975
42MP0010386_abnormal_urinary_bladder0.77148478
43MP0001340_abnormal_eyelid_morphology0.72780555
44MP0009780_abnormal_chondrocyte_physiolo0.71058416
45MP0001986_abnormal_taste_sensitivity0.70665403
46MP0003315_abnormal_perineum_morphology0.69706226
47MP0006054_spinal_hemorrhage0.69675782
48MP0009053_abnormal_anal_canal0.67997668
49MP0000537_abnormal_urethra_morphology0.67665306
50MP0003329_amyloid_beta_deposits0.63619141
51MP0001784_abnormal_fluid_regulation0.63424981
52MP0002282_abnormal_trachea_morphology0.62353899
53MP0004264_abnormal_extraembryonic_tissu0.57382115
54MP0005409_darkened_coat_color0.57186360
55MP0000566_synostosis0.56722402
56MP0009379_abnormal_foot_pigmentation0.53916337
57MP0003195_calcinosis0.50922972
58MP0005023_abnormal_wound_healing0.50736906
59MP0002177_abnormal_outer_ear0.50252626
60MP0000015_abnormal_ear_pigmentation0.49371852
61MP0005174_abnormal_tail_pigmentation0.48986531
62MP0001177_atelectasis0.47604685
63MP0005075_abnormal_melanosome_morpholog0.47299774
64MP0001188_hyperpigmentation0.47277945
65MP0008961_abnormal_basal_metabolism0.47231972
66MP0002249_abnormal_larynx_morphology0.47072495
67MP0005666_abnormal_adipose_tissue0.46861946
68MP0005367_renal/urinary_system_phenotyp0.46568856
69MP0000516_abnormal_urinary_system0.46568856
70MP0005257_abnormal_intraocular_pressure0.45112813
71MP0002166_altered_tumor_susceptibility0.44365502
72MP0003755_abnormal_palate_morphology0.40349494
73MP0005375_adipose_tissue_phenotype0.37507646
74MP0002877_abnormal_melanocyte_morpholog0.36862493
75MP0003638_abnormal_response/metabolism_0.36493235
76MP0000627_abnormal_mammary_gland0.34303230
77MP0002006_tumorigenesis0.33859959
78MP0009384_cardiac_valve_regurgitation0.33601362
79MP0000538_abnormal_urinary_bladder0.33309290
80MP0002090_abnormal_vision0.30932002
81MP0008438_abnormal_cutaneous_collagen0.28296865
82MP0002896_abnormal_bone_mineralization0.28002931
83MP0002277_abnormal_respiratory_mucosa0.27448071
84MP0002095_abnormal_skin_pigmentation0.27212718
85MP0008789_abnormal_olfactory_epithelium0.26036369
86MP0002111_abnormal_tail_morphology0.25979550
87MP0005508_abnormal_skeleton_morphology0.25330952
88MP0005076_abnormal_cell_differentiation0.24485344
89MP0001984_abnormal_olfaction0.23985952
90MP0000432_abnormal_head_morphology0.23782701
91MP0000013_abnormal_adipose_tissue0.23358933
92MP0001542_abnormal_bone_strength0.22176474
93MP0000604_amyloidosis0.22026671
94MP0002697_abnormal_eye_size0.21586141
95MP0004019_abnormal_vitamin_homeostasis0.21289184
96MP0005193_abnormal_anterior_eye0.21158410
97MP0009672_abnormal_birth_weight0.21064738
98MP0004272_abnormal_basement_membrane0.20572557
99MP0001502_abnormal_circadian_rhythm0.20288741
100MP0010030_abnormal_orbit_morphology0.19770079
101MP0001849_ear_inflammation0.19625335
102MP0002233_abnormal_nose_morphology0.17973646
103MP0004043_abnormal_pH_regulation0.17193395
104MP0005499_abnormal_olfactory_system0.16520545
105MP0005394_taste/olfaction_phenotype0.16520545
106MP0010352_gastrointestinal_tract_polyps0.16330178
107MP0000462_abnormal_digestive_system0.15628140
108MP0002133_abnormal_respiratory_system0.15565800
109MP0005388_respiratory_system_phenotype0.15565800
110MP0001881_abnormal_mammary_gland0.15356700
111MP0004197_abnormal_fetal_growth/weight/0.14713082
112MP0003763_abnormal_thymus_physiology0.14654573
113MP0005248_abnormal_Harderian_gland0.14446987
114MP0005623_abnormal_meninges_morphology0.13575812
115MP0008004_abnormal_stomach_pH0.13316064
116MP0001299_abnormal_eye_distance/0.12346421
117MP0000428_abnormal_craniofacial_morphol0.12272542
118MP0005197_abnormal_uvea_morphology0.12035909
119MP0000470_abnormal_stomach_morphology0.11718358
120MP0005187_abnormal_penis_morphology0.11623468
121MP0001485_abnormal_pinna_reflex0.11480334
122MP0001186_pigmentation_phenotype0.09242547
123MP0002136_abnormal_kidney_physiology0.09188769
124MP0000569_abnormal_digit_pigmentation0.07922331
125MP0008569_lethality_at_weaning0.07080555
126MP0001756_abnormal_urination0.06548755

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.95040028
2Congenital ichthyosiform erythroderma (HP:0007431)8.61809335
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.60574198
4Hypotrichosis (HP:0001006)7.32888334
5Palmoplantar hyperkeratosis (HP:0000972)6.46168754
6Woolly hair (HP:0002224)6.18275667
7Plantar hyperkeratosis (HP:0007556)6.10206134
8Palmar hyperkeratosis (HP:0010765)6.08618328
9Erythroderma (HP:0001019)5.72764631
10Erythema (HP:0010783)5.59168037
11Right ventricular cardiomyopathy (HP:0011663)5.45338372
12Onycholysis (HP:0001806)5.34967071
13Gangrene (HP:0100758)5.25458886
14Parakeratosis (HP:0001036)5.23556736
15Thick nail (HP:0001805)4.91749147
16Fragile nails (HP:0001808)4.74489153
17Ectropion (HP:0000656)4.69722093
18Lip pit (HP:0100267)4.43231205
19Corneal erosion (HP:0200020)4.23482639
20Natal tooth (HP:0000695)4.15599199
21Abnormal blistering of the skin (HP:0008066)3.93660289
22Hypohidrosis (HP:0000966)3.92500839
23Pili torti (HP:0003777)3.91874664
24Nail dystrophy (HP:0008404)3.90226829
25Palmoplantar keratoderma (HP:0000982)3.78309773
26Pruritus (HP:0000989)3.67301858
27Eczematoid dermatitis (HP:0000976)3.66638714
28Hyporeflexia of lower limbs (HP:0002600)3.65584959
29Absent eyelashes (HP:0000561)3.63152810
30Curly hair (HP:0002212)3.61364895
31Alopecia of scalp (HP:0002293)3.48605233
32Advanced eruption of teeth (HP:0006288)3.36918087
33Milia (HP:0001056)3.34629996
34Lack of skin elasticity (HP:0100679)3.21926884
35Sparse eyelashes (HP:0000653)3.21329806
36Brittle hair (HP:0002299)3.18188410
37Sparse scalp hair (HP:0002209)3.09544619
38Conjunctival hamartoma (HP:0100780)3.06617162
39Absent hair (HP:0002298)3.06021039
40Amniotic constriction ring (HP:0009775)2.90536179
41Abnormality of placental membranes (HP:0011409)2.90536179
42Acanthosis nigricans (HP:0000956)2.90327240
43Follicular hyperkeratosis (HP:0007502)2.89455552
44Distal lower limb muscle weakness (HP:0009053)2.83085667
45Ventricular tachycardia (HP:0004756)2.81318526
46Oral leukoplakia (HP:0002745)2.81248113
47Hypergammaglobulinemia (HP:0010702)2.71227856
48Selective tooth agenesis (HP:0001592)2.67200219
49Corneal dystrophy (HP:0001131)2.58978786
50Dehydration (HP:0001944)2.58914176
51Furrowed tongue (HP:0000221)2.54841135
52Malignant hyperthermia (HP:0002047)2.47561194
53Dry skin (HP:0000958)2.44724869
54Abnormal hair laboratory examination (HP:0003328)2.42941934
55Dry hair (HP:0011359)2.40459537
56Severe Myopia (HP:0011003)2.34297406
57Laryngomalacia (HP:0001601)2.34167072
58Ridged nail (HP:0001807)2.32962386
59Areflexia of lower limbs (HP:0002522)2.31770376
60Abnormality of secondary sexual hair (HP:0009888)2.27001766
61Abnormality of the axillary hair (HP:0100134)2.27001766
62Concave nail (HP:0001598)2.26767281
63Premature ovarian failure (HP:0008209)2.21869985
64Abnormality of the labia majora (HP:0012881)2.21216287
65Autoamputation (HP:0001218)2.20409903
66Hyperhidrosis (HP:0000975)2.13366809
67Congenital, generalized hypertrichosis (HP:0004540)2.07329065
68Abnormality of nail color (HP:0100643)11.4426606
69Anonychia (HP:0001798)1.98832695
70Septate vagina (HP:0001153)1.96826911
71Sepsis (HP:0100806)1.96480645
72Abnormality of small intestinal villus morphology (HP:0011472)1.92329003
73Villous atrophy (HP:0011473)1.92329003
74Ventricular fibrillation (HP:0001663)1.90181896
75Multifactorial inheritance (HP:0001426)1.87464297
76Epidermoid cyst (HP:0200040)1.87399424
77Hypoplasia of dental enamel (HP:0006297)1.85021705
78Melanocytic nevus (HP:0000995)1.81754841
79Abnormality of the salivary glands (HP:0010286)1.80615615
80Abnormality of the neuromuscular junction (HP:0003398)1.77101592
81Fatigable weakness (HP:0003473)1.77101592
82Sensory axonal neuropathy (HP:0003390)1.76720858
83Split foot (HP:0001839)1.76332988
84Urticaria (HP:0001025)1.74795015
85Achilles tendon contracture (HP:0001771)1.73693043
86Atrophic scars (HP:0001075)1.72115018
87Xerostomia (HP:0000217)1.71156209
88Blepharitis (HP:0000498)1.68726076
89Hamartoma of the eye (HP:0010568)1.68223376
90Abnormality of the gastric mucosa (HP:0004295)1.68175964
91Asthma (HP:0002099)1.65657771
92Skin ulcer (HP:0200042)1.64793480
93Abnormality of permanent molar morphology (HP:0011071)1.64329507
94Abnormality of the dental root (HP:0006486)1.64329507
95Taurodontia (HP:0000679)1.64329507
96Popliteal pterygium (HP:0009756)1.63842046
97Conical tooth (HP:0000698)1.61348811
98Abnormality of the Achilles tendon (HP:0005109)1.60597422
99Duplicated collecting system (HP:0000081)1.59359330
100Recurrent corneal erosions (HP:0000495)1.58984384
101Abnormality of hair growth rate (HP:0011363)1.58942382
102Slow-growing hair (HP:0002217)1.58942382
103Nasolacrimal duct obstruction (HP:0000579)1.57683704
104Paralysis (HP:0003470)1.55730065
105Labial hypoplasia (HP:0000066)1.55246341
106Abnormality of molar morphology (HP:0011070)1.52422310
107Abnormality of molar (HP:0011077)1.52422310
108Pterygium (HP:0001059)1.48922868
109Pustule (HP:0200039)1.47991347
110Aplasia involving bones of the extremities (HP:0009825)1.47461636
111Aplasia of the phalanges of the hand (HP:0009802)1.47461636
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.45946807
113Abnormality of the fingernails (HP:0001231)1.44359906
114Everted lower lip vermilion (HP:0000232)1.43668112
115Skin pits (HP:0100276)1.43654903
116Sudden death (HP:0001699)1.42373447
117Hypoplastic labia majora (HP:0000059)1.42113267
118Oligodontia (HP:0000677)1.40651191
119Carious teeth (HP:0000670)1.39253262
120Fasciculations (HP:0002380)1.35603592
121Ulnar claw (HP:0001178)1.31909826
122Hoarse voice (HP:0001609)1.31131008
123Fine hair (HP:0002213)1.30501932
124Anhidrosis (HP:0000970)1.28756564
125Aplasia cutis congenita (HP:0001057)1.28602106
126Amelogenesis imperfecta (HP:0000705)1.27223330
127Increased connective tissue (HP:0009025)1.26117624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.43913633
2MAPKAPK35.30517329
3TGFBR14.55368799
4FER4.29318735
5LATS13.61517646
6MAP3K33.50471887
7MST1R3.18913499
8MAP3K22.83357060
9EPHB22.67465919
10RPS6KB22.41831733
11FGFR12.37560487
12ERN11.95691102
13TNK21.82224010
14BCR1.70330510
15LATS21.66608306
16TRPM71.65868894
17PBK1.58371144
18PIM21.56410051
19LMTK21.50507430
20EPHA21.43520447
21PIK3CG1.40950284
22ERBB31.23526891
23GRK11.21732420
24DYRK1B1.21366737
25STK38L1.21230841
26SRPK11.20670559
27ITK1.15794481
28MAPKAPK51.14519309
29LRRK21.14024598
30MAP3K71.11355074
31PAK31.11302171
32TAOK11.10998481
33MAP3K111.09208637
34FRK1.07034898
35RIPK11.02222618
36PTK61.00833695
37EPHA30.98622125
38ABL20.96903464
39MAP3K90.95492257
40CASK0.95237489
41STK240.95012003
42MAP3K10.93615053
43STK100.92864087
44AURKA0.91176677
45SGK4940.90334792
46SGK2230.90334792
47MAP2K60.89356903
48IKBKB0.88187810
49EPHB10.84528142
50CSNK1D0.82755127
51MAPKAPK20.82679522
52RIPK40.81750270
53IRAK10.79844329
54TESK10.78934088
55MAPK70.76340716
56SIK10.75978930
57NEK60.75935057
58FGFR40.73529211
59TTN0.73240736
60MAP3K60.72498504
61PRKD10.72230035
62PRKCE0.72224749
63DDR20.71354808
64EPHA40.71306117
65NTRK10.70170868
66CDK60.70089898
67MET0.70043605
68MAP2K30.70019066
69BLK0.69108013
70DYRK30.68879931
71ERBB40.68642029
72STK390.66369907
73RPS6KB10.66180118
74FGFR20.63415724
75BMPR20.61725828
76FGR0.59979464
77TEC0.59805992
78MAP2K40.59077441
79PKN10.57818763
80ROCK10.56694546
81MAP3K140.56145720
82RPS6KA10.55857666
83MAP3K120.55844443
84GRK50.55653901
85WNK10.55345183
86TRIB30.55031468
87PHKG20.54052558
88PHKG10.54052558
89PDGFRB0.53066599
90BMX0.52070786
91EEF2K0.50390446
92MAP2K10.50039254
93CDK30.49838060
94TBK10.49276376
95STK30.48411995
96CDK120.47809492
97OBSCN0.46961289
98BMPR1B0.45616222
99ADRBK10.45122938
100PRKCI0.45117327
101STK380.43621669
102LIMK10.42032971
103FGFR30.41617922
104EIF2AK20.38860332
105STK110.38557608
106IRAK20.38412975
107NTRK20.38398587
108MAPK40.38041726
109MAP3K50.38007656
110ERBB20.36739752
111EIF2AK30.36720181
112DYRK1A0.36294008
113MARK20.34536417
114TYRO30.33426427
115PDGFRA0.33188185
116MUSK0.32808843
117HIPK20.32526173
118BRD40.31903700
119DMPK0.31125278
120GSK3A0.30114051
121SYK0.30048192
122PTK20.29160138
123TYK20.29126743
124PRKCA0.27411803
125NLK0.27395188
126ABL10.27197811
127SGK30.26003297
128FLT30.25981422
129ILK0.25526153
130TGFBR20.25391793
131IGF1R0.24884044
132ARAF0.24636682
133RPS6KA40.24576731
134MAPK120.24335162
135TLK10.19259093
136CSNK1E0.19037201
137PINK10.18796347
138SGK20.18422394
139OXSR10.16864835
140GRK60.16454713
141SGK10.16109938
142PRKCD0.15825757
143KSR20.15051871
144TAF10.14918876
145CHUK0.13492020
146MYLK0.13351577
147RET0.12713204
148PDK20.10113842

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.66995756
2Linoleic acid metabolism_Homo sapiens_hsa005913.81940629
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.70152253
4Fatty acid elongation_Homo sapiens_hsa000623.46206839
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.04083002
6Arachidonic acid metabolism_Homo sapiens_hsa005902.82583737
7Ether lipid metabolism_Homo sapiens_hsa005652.45734603
8ABC transporters_Homo sapiens_hsa020102.26306896
9Histidine metabolism_Homo sapiens_hsa003402.13152445
10Tight junction_Homo sapiens_hsa045301.91958849
11Ovarian steroidogenesis_Homo sapiens_hsa049131.85439828
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70258412
13Fat digestion and absorption_Homo sapiens_hsa049751.67369364
14Phenylalanine metabolism_Homo sapiens_hsa003601.52241869
15Collecting duct acid secretion_Homo sapiens_hsa049661.48919938
16Sphingolipid signaling pathway_Homo sapiens_hsa040711.47860926
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40966972
18Ribosome_Homo sapiens_hsa030101.40400261
19Adherens junction_Homo sapiens_hsa045201.33041368
20Axon guidance_Homo sapiens_hsa043601.29342453
21Phototransduction_Homo sapiens_hsa047441.28574648
22VEGF signaling pathway_Homo sapiens_hsa043701.21497417
23Retinol metabolism_Homo sapiens_hsa008301.17534042
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.15062425
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12163344
26GnRH signaling pathway_Homo sapiens_hsa049121.11174138
27ECM-receptor interaction_Homo sapiens_hsa045121.11101030
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08118402
29Graft-versus-host disease_Homo sapiens_hsa053321.07718399
30Melanogenesis_Homo sapiens_hsa049161.05098743
31ErbB signaling pathway_Homo sapiens_hsa040121.03330398
32Hippo signaling pathway_Homo sapiens_hsa043901.01851343
33Long-term potentiation_Homo sapiens_hsa047201.00631081
34Basal cell carcinoma_Homo sapiens_hsa052170.98037446
35Pertussis_Homo sapiens_hsa051330.96223593
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95089156
37Mineral absorption_Homo sapiens_hsa049780.94503769
38Steroid biosynthesis_Homo sapiens_hsa001000.91979386
39Staphylococcus aureus infection_Homo sapiens_hsa051500.91737347
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91689533
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.90747550
42Hepatitis C_Homo sapiens_hsa051600.90240801
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88544470
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87076521
45Renin secretion_Homo sapiens_hsa049240.83765677
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83477705
47Ras signaling pathway_Homo sapiens_hsa040140.83354708
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.83204400
49Choline metabolism in cancer_Homo sapiens_hsa052310.81987236
50Proteoglycans in cancer_Homo sapiens_hsa052050.80813644
51Caffeine metabolism_Homo sapiens_hsa002320.79470848
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79094025
53Fatty acid biosynthesis_Homo sapiens_hsa000610.79010124
54Chemical carcinogenesis_Homo sapiens_hsa052040.78764749
55Olfactory transduction_Homo sapiens_hsa047400.78629039
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77869436
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75871475
58Bladder cancer_Homo sapiens_hsa052190.74387055
59Pancreatic secretion_Homo sapiens_hsa049720.73020636
60Tyrosine metabolism_Homo sapiens_hsa003500.72594493
61Small cell lung cancer_Homo sapiens_hsa052220.70974891
62Gastric acid secretion_Homo sapiens_hsa049710.70633460
63Arginine biosynthesis_Homo sapiens_hsa002200.68139213
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66541774
65Serotonergic synapse_Homo sapiens_hsa047260.65780928
66Glutathione metabolism_Homo sapiens_hsa004800.65734801
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64687166
68Protein digestion and absorption_Homo sapiens_hsa049740.63632888
69Rap1 signaling pathway_Homo sapiens_hsa040150.61918717
70Lysosome_Homo sapiens_hsa041420.60817630
71Oxytocin signaling pathway_Homo sapiens_hsa049210.60762728
72Glutamatergic synapse_Homo sapiens_hsa047240.59850522
73Salivary secretion_Homo sapiens_hsa049700.58220520
74Long-term depression_Homo sapiens_hsa047300.57097141
75Circadian rhythm_Homo sapiens_hsa047100.56973388
76Thyroid cancer_Homo sapiens_hsa052160.56923984
77Amoebiasis_Homo sapiens_hsa051460.56624143
78Glioma_Homo sapiens_hsa052140.55615326
79Rheumatoid arthritis_Homo sapiens_hsa053230.54782952
80Wnt signaling pathway_Homo sapiens_hsa043100.52624295
81Hedgehog signaling pathway_Homo sapiens_hsa043400.51336948
82Malaria_Homo sapiens_hsa051440.51071762
83MicroRNAs in cancer_Homo sapiens_hsa052060.50972042
84Platelet activation_Homo sapiens_hsa046110.49612285
85Vibrio cholerae infection_Homo sapiens_hsa051100.49282295
86TGF-beta signaling pathway_Homo sapiens_hsa043500.48745957
87Inositol phosphate metabolism_Homo sapiens_hsa005620.48073577
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47935541
89Tuberculosis_Homo sapiens_hsa051520.47083998
90Endocytosis_Homo sapiens_hsa041440.47001756
91Estrogen signaling pathway_Homo sapiens_hsa049150.46920423
92Dorso-ventral axis formation_Homo sapiens_hsa043200.46771950
93PPAR signaling pathway_Homo sapiens_hsa033200.45947713
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44690890
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44405197
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43356205
97Amphetamine addiction_Homo sapiens_hsa050310.41998116
98p53 signaling pathway_Homo sapiens_hsa041150.41977192
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41747120
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.41381534
101T cell receptor signaling pathway_Homo sapiens_hsa046600.40234119
102Glycerolipid metabolism_Homo sapiens_hsa005610.39314101
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39139451
104beta-Alanine metabolism_Homo sapiens_hsa004100.38448653
105Toxoplasmosis_Homo sapiens_hsa051450.38411560
106Insulin resistance_Homo sapiens_hsa049310.38320258
107Notch signaling pathway_Homo sapiens_hsa043300.37967187
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37122592
109Pathways in cancer_Homo sapiens_hsa052000.36895045
110Nitrogen metabolism_Homo sapiens_hsa009100.36771578
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33607498
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33078548
113Vitamin digestion and absorption_Homo sapiens_hsa049770.32483541
114Phagosome_Homo sapiens_hsa041450.31460499
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.30965015
116Arginine and proline metabolism_Homo sapiens_hsa003300.30222377
117Gap junction_Homo sapiens_hsa045400.29880531
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.28094733
119Focal adhesion_Homo sapiens_hsa045100.26875642
120Insulin signaling pathway_Homo sapiens_hsa049100.25707042
121Taste transduction_Homo sapiens_hsa047420.25598575
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25387268
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23969712

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