KLK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)8.74425947
2ribosomal small subunit assembly (GO:0000028)8.35492097
3bundle of His cell to Purkinje myocyte communication (GO:0086069)8.05918041
4hemidesmosome assembly (GO:0031581)7.62029096
5viral transcription (GO:0019083)7.49952604
6peptide cross-linking (GO:0018149)7.34606263
7multicellular organismal water homeostasis (GO:0050891)7.29685174
8translational termination (GO:0006415)7.18150617
9* keratinocyte proliferation (GO:0043616)7.01971697
10epidermal cell differentiation (GO:0009913)6.95306891
11ribosomal small subunit biogenesis (GO:0042274)6.87943497
12epidermis development (GO:0008544)6.45851852
13keratinocyte development (GO:0003334)6.35607915
14maturation of SSU-rRNA (GO:0030490)6.26587987
15translational elongation (GO:0006414)6.13595521
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.07683770
17water homeostasis (GO:0030104)6.04171512
18cotranslational protein targeting to membrane (GO:0006613)5.95285871
19protein targeting to ER (GO:0045047)5.93487300
20establishment of protein localization to endoplasmic reticulum (GO:0072599)5.66536254
21protein localization to endoplasmic reticulum (GO:0070972)5.61448639
22viral life cycle (GO:0019058)5.60171731
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.50075695
24cellular protein complex disassembly (GO:0043624)5.43728544
25keratinization (GO:0031424)5.31662496
26negative regulation of keratinocyte proliferation (GO:0010839)5.19291065
27gap junction assembly (GO:0016264)5.18125050
28translational initiation (GO:0006413)5.15681406
29intermediate filament organization (GO:0045109)4.93072634
30DNA deamination (GO:0045006)4.90190961
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76814282
32protein complex disassembly (GO:0043241)4.72319936
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60131006
34establishment of skin barrier (GO:0061436)4.53827031
35ribosomal large subunit biogenesis (GO:0042273)4.43538817
36macromolecular complex disassembly (GO:0032984)4.43258558
37intermediate filament cytoskeleton organization (GO:0045104)4.32095746
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31532227
39positive regulation of epidermis development (GO:0045684)4.25788533
40long-chain fatty acid biosynthetic process (GO:0042759)4.21261250
41positive regulation of epidermal cell differentiation (GO:0045606)4.19164958
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18859470
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18859470
44intermediate filament-based process (GO:0045103)4.14565424
45nuclear-transcribed mRNA catabolic process (GO:0000956)4.04739355
46skin morphogenesis (GO:0043589)4.01994941
47protein targeting to membrane (GO:0006612)3.99536325
48desmosome organization (GO:0002934)3.97161178
49lipoxygenase pathway (GO:0019372)3.92558723
50negative regulation of cell fate specification (GO:0009996)3.88441714
51regulation of water loss via skin (GO:0033561)3.85895882
52mRNA catabolic process (GO:0006402)3.85461508
53regulation of keratinocyte proliferation (GO:0010837)3.76331552
54positive regulation of gamma-delta T cell activation (GO:0046645)3.71334271
55ribonucleoprotein complex biogenesis (GO:0022613)3.71163659
56regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.70606219
57phosphatidylserine acyl-chain remodeling (GO:0036150)3.65550351
58regulation of B cell receptor signaling pathway (GO:0050855)3.62626268
59RNA catabolic process (GO:0006401)3.59111065
60translation (GO:0006412)3.54950378
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53317068
62ATP synthesis coupled proton transport (GO:0015986)3.53317068
63platelet dense granule organization (GO:0060155)3.52479862
64ectoderm development (GO:0007398)3.50061567
65polarized epithelial cell differentiation (GO:0030859)3.47107098
66establishment of tissue polarity (GO:0007164)3.39871685
67establishment of planar polarity (GO:0001736)3.39871685
68antigen processing and presentation of endogenous antigen (GO:0019883)3.36310443
69negative T cell selection (GO:0043383)3.30918520
70response to interferon-beta (GO:0035456)3.30591534
71negative thymic T cell selection (GO:0045060)3.28965008
72formation of translation preinitiation complex (GO:0001731)3.28472698
73antigen processing and presentation via MHC class Ib (GO:0002475)3.28326804
74regulation of epidermis development (GO:0045682)3.26695755
75Arp2/3 complex-mediated actin nucleation (GO:0034314)3.22865778
76phosphatidylinositol acyl-chain remodeling (GO:0036149)3.19956322
77negative regulation of cell fate commitment (GO:0010454)3.19287828
78thymic T cell selection (GO:0045061)3.16714196
79epithelium development (GO:0060429)3.14606965
80intestinal epithelial cell development (GO:0060576)3.13655834
81fatty acid elongation (GO:0030497)3.12036392
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.11772368
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10324342
84mast cell activation (GO:0045576)3.09574104
85regulation of transforming growth factor beta1 production (GO:0032908)3.03126267
86regulation of isotype switching to IgG isotypes (GO:0048302)3.03045139
87regulation of gamma-delta T cell differentiation (GO:0045586)3.02292894
88chaperone-mediated protein transport (GO:0072321)3.02287691
89regulation of T cell receptor signaling pathway (GO:0050856)3.01659257
90positive thymic T cell selection (GO:0045059)3.01588735
91regulation of epidermal cell differentiation (GO:0045604)3.01492345
92positive regulation of interleukin-8 secretion (GO:2000484)2.97280675
93definitive hemopoiesis (GO:0060216)2.96676416
94telomere maintenance via semi-conservative replication (GO:0032201)2.95997613
95eyelid development in camera-type eye (GO:0061029)2.95874948
96leukocyte aggregation (GO:0070486)2.95858174
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94391776
98mature B cell differentiation involved in immune response (GO:0002313)2.93586749
99cellular response to interleukin-15 (GO:0071350)2.92438640
100respiratory electron transport chain (GO:0022904)2.91302338
101phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.91042700
102response to interleukin-15 (GO:0070672)2.90730783
103morphogenesis of embryonic epithelium (GO:0016331)2.90476339
104interferon-gamma production (GO:0032609)2.89176616
105interferon-gamma secretion (GO:0072643)2.88678093
106rRNA processing (GO:0006364)2.88531838
107DNA strand elongation involved in DNA replication (GO:0006271)2.87664949
108T cell receptor signaling pathway (GO:0050852)2.86275907
109megakaryocyte development (GO:0035855)2.86000226
110electron transport chain (GO:0022900)2.83852079
111DNA strand elongation (GO:0022616)2.83409752
112surfactant homeostasis (GO:0043129)2.81758146
113T cell selection (GO:0045058)2.81547117
114regulation of cardioblast differentiation (GO:0051890)2.80389145
115cellular response to interleukin-4 (GO:0071353)2.79961542
116regulation of T cell mediated cytotoxicity (GO:0001914)2.79572496
117negative regulation of erythrocyte differentiation (GO:0045647)2.79489293
118hair cycle (GO:0042633)2.78745195
119molting cycle (GO:0042303)2.78745195
120rRNA metabolic process (GO:0016072)2.78023667
121cellular component biogenesis (GO:0044085)2.77760759
122notochord development (GO:0030903)2.76326590
123regulation of mitochondrial translation (GO:0070129)2.73568283
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72269278
125negative regulation of cell killing (GO:0031342)2.72269278
126sequestering of actin monomers (GO:0042989)2.72007713
127phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71748656
128cell-substrate junction assembly (GO:0007044)2.71153952
129negative regulation of transcription by competitive promoter binding (GO:0010944)2.71034627
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70177417
131T cell homeostasis (GO:0043029)2.69661591
132negative regulation of T cell receptor signaling pathway (GO:0050860)2.69525215
133establishment of protein localization to membrane (GO:0090150)2.68869249
134antigen receptor-mediated signaling pathway (GO:0050851)2.68385825
135regulation of cellular amino acid metabolic process (GO:0006521)2.67471499
136pseudouridine synthesis (GO:0001522)2.67455224
137regulation of keratinocyte differentiation (GO:0045616)2.66714315
138negative regulation of epidermis development (GO:0045683)2.66534399
139positive T cell selection (GO:0043368)2.66176577
140regulation of gamma-delta T cell activation (GO:0046643)2.64968408
141linoleic acid metabolic process (GO:0043651)2.64697511
142chemical homeostasis within a tissue (GO:0048875)2.64284642
143regulation of cell proliferation involved in kidney development (GO:1901722)2.63101360
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.62246043
145mast cell activation involved in immune response (GO:0002279)2.61480317
146mast cell degranulation (GO:0043303)2.61480317
147regulation of hair follicle development (GO:0051797)2.61374935
148negative regulation of T cell mediated immunity (GO:0002710)2.60805417
149negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60187167
150positive regulation of lamellipodium assembly (GO:0010592)2.60101130
151positive regulation of hair follicle development (GO:0051798)2.55715079
152positive regulation of hair cycle (GO:0042635)2.55715079
153skin development (GO:0043588)2.55706735
154cellular response to type I interferon (GO:0071357)2.54491108
155type I interferon signaling pathway (GO:0060337)2.54491108
156positive regulation of monocyte chemotaxis (GO:0090026)2.52849477
157positive regulation of keratinocyte differentiation (GO:0045618)2.52757323
158positive regulation of granulocyte differentiation (GO:0030854)2.52534681
159response to type I interferon (GO:0034340)2.52354468
160DNA replication initiation (GO:0006270)2.51781870
161positive regulation of T cell mediated cytotoxicity (GO:0001916)2.50445545
162lymphoid progenitor cell differentiation (GO:0002320)2.49964612
163positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.49409923
164DNA unwinding involved in DNA replication (GO:0006268)2.48877819
165ventricular cardiac muscle cell action potential (GO:0086005)2.48849444
166T cell differentiation (GO:0030217)2.48151193
167regulation of regulatory T cell differentiation (GO:0045589)2.48129424
168proteasome assembly (GO:0043248)2.47783835
169regulation of T cell tolerance induction (GO:0002664)2.47531829
170lateral sprouting from an epithelium (GO:0060601)2.47315021
171T cell migration (GO:0072678)2.46913039
172hair follicle morphogenesis (GO:0031069)2.46590769
173regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45178264
174branching involved in labyrinthine layer morphogenesis (GO:0060670)2.44554694
175negative regulation of interferon-gamma production (GO:0032689)2.44281919
176rRNA modification (GO:0000154)2.43639162
177phosphatidylcholine acyl-chain remodeling (GO:0036151)2.43112037
178phosphatidylserine metabolic process (GO:0006658)2.42985472
179apical protein localization (GO:0045176)2.40771529
180response to phenylpropanoid (GO:0080184)2.40227831
181negative regulation of ligase activity (GO:0051352)2.39790138
182negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.39790138
183regulation of cell fate specification (GO:0042659)2.37791726
184cell-cell junction assembly (GO:0007043)2.37660987
185primary alcohol catabolic process (GO:0034310)2.37627731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.95833974
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.24902843
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.14833732
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.00171661
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63885895
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.55588936
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23435822
8ZNF263_19887448_ChIP-Seq_K562_Human3.00508601
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91629940
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.88960025
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.82454027
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.78824212
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.75098863
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69593633
15SCL_19346495_ChIP-Seq_HPC-7_Human2.67140370
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64579199
17TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.55185955
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.52296684
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48681999
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.48318465
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47027591
22MYC_22102868_ChIP-Seq_BL_Human2.46034649
23* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.41539750
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.38699193
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37772587
26STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28923501
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26939348
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.21071435
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.14481831
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.14481831
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.14481831
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12502453
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.12402071
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.12402071
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12322069
36ETS1_20019798_ChIP-Seq_JURKAT_Human2.12062238
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08032170
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03932355
39VDR_23849224_ChIP-Seq_CD4+_Human1.99536608
40SPI1_23547873_ChIP-Seq_NB4_Human1.97949412
41XRN2_22483619_ChIP-Seq_HELA_Human1.96674647
42MYB_26560356_Chip-Seq_TH2_Human1.95581159
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93937301
44ATF3_27146783_Chip-Seq_COLON_Human1.87777656
45MAF_26560356_Chip-Seq_TH1_Human1.87504074
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85627534
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83827139
48VDR_21846776_ChIP-Seq_THP-1_Human1.83382060
49STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83204933
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78630085
51AR_21909140_ChIP-Seq_LNCAP_Human1.77112592
52FOXP3_21729870_ChIP-Seq_TREG_Human1.76911597
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.76781046
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74832437
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72851546
56UTX_26944678_Chip-Seq_JUKART_Human1.71758171
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70867921
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70510687
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68853177
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68336800
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67963241
62MYB_26560356_Chip-Seq_TH1_Human1.67275514
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65820896
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65063672
65TTF2_22483619_ChIP-Seq_HELA_Human1.63540850
66FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63355733
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57882447
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.57166225
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.56578887
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53939453
71RACK7_27058665_Chip-Seq_MCF-7_Human1.50653134
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.50195336
73RUNX_20019798_ChIP-Seq_JUKART_Human1.49864404
74DCP1A_22483619_ChIP-Seq_HELA_Human1.48418717
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47210029
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46321565
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45210708
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44541251
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43766464
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42222821
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42096214
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41865300
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41188410
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39125587
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37548768
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37362718
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36083524
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35730664
89BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33105838
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32449726
91ELK1_19687146_ChIP-ChIP_HELA_Human1.31662629
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.29850377
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29631313
94CIITA_25753668_ChIP-Seq_RAJI_Human1.29426821
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.28543146
96MAF_26560356_Chip-Seq_TH2_Human1.27952062
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27429214
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27307484
99SOX2_20726797_ChIP-Seq_SW620_Human1.27193141
100TP63_22573176_ChIP-Seq_HFKS_Human1.24957821
101TCF7_22412390_ChIP-Seq_EML_Mouse1.22511845
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22378927
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22263933
104GABP_19822575_ChIP-Seq_HepG2_Human1.22010833
105VDR_24763502_ChIP-Seq_THP-1_Human1.21806815
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20477476
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.20070026
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19699317
109GATA6_25053715_ChIP-Seq_YYC3_Human1.18673073
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16415518
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15374863
112EGR1_19032775_ChIP-ChIP_M12_Human1.14764714
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.13382215
114GATA6_21074721_ChIP-Seq_CACO-2_Human1.12144972
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11265588
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.11004937
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10643257
118ELF5_23300383_ChIP-Seq_T47D_Human1.10641250
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10507728
120KLF5_25053715_ChIP-Seq_YYC3_Human1.08519703
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08464316
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.06127322
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05530563
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04146139
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03605595
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03373738
127MYC_18940864_ChIP-ChIP_HL60_Human1.02614811
128ELK1_22589737_ChIP-Seq_MCF10A_Human1.02399173
129KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01936943
130ELK3_25401928_ChIP-Seq_HUVEC_Human1.01427954
131P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00870441
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97899448
133GATA4_25053715_ChIP-Seq_YYC3_Human0.97751776
134TP63_23658742_ChIP-Seq_EP156T_Human0.97435447
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97150193
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96976132
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96349157
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95981500
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95143150
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.94888836
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.94761400
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.94415890
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94141911
144GATA3_27048872_Chip-Seq_THYMUS_Human0.94065202
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93992911
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93692216
147NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93274551
148RBPJ_21746931_ChIP-Seq_IB4_Human0.92041892
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91858623
150SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91838021
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90986573
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90579555
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89876871
154CLOCK_20551151_ChIP-Seq_293T_Human0.89614754
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89568426
156CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89538521
157CTCF_20526341_ChIP-Seq_ESCs_Human0.89397596
158ERG_20517297_ChIP-Seq_VCAP_Human0.88394554
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87801537
160CTCF_27219007_Chip-Seq_Bcells_Human0.87585497
161BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87032710
162OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86006513
163P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.85703524
164HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84200122
165PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83783415
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83537110
167SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82083935
168* SMC4_20622854_ChIP-Seq_HELA_Human0.82046118
169ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81689038
170POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81478979
171TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79518044
172P53_21459846_ChIP-Seq_SAOS-2_Human0.79261840
173CHD1_26751641_Chip-Seq_LNCaP_Human0.79013137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.08213631
2MP0002796_impaired_skin_barrier3.86274927
3MP0005671_abnormal_response_to3.38323321
4MP0009379_abnormal_foot_pigmentation3.35737876
5MP0002396_abnormal_hematopoietic_system3.08208345
6MP0005501_abnormal_skin_physiology2.82286021
7MP0001835_abnormal_antigen_presentation2.77423629
8MP0000566_synostosis2.56628271
9MP0004381_abnormal_hair_follicle2.55269389
10MP0000685_abnormal_immune_system2.50836472
11MP0010234_abnormal_vibrissa_follicle2.48013051
12MP0000762_abnormal_tongue_morphology2.43153763
13MP0009785_altered_susceptibility_to2.40638706
14MP0009333_abnormal_splenocyte_physiolog2.39985721
15MP0004264_abnormal_extraembryonic_tissu2.37952408
16MP0002166_altered_tumor_susceptibility2.37482894
17MP0004947_skin_inflammation2.36288055
18MP0002398_abnormal_bone_marrow2.26638299
19MP0001800_abnormal_humoral_immune2.24202271
20MP0000465_gastrointestinal_hemorrhage2.22305610
21MP0002420_abnormal_adaptive_immunity2.18383534
22MP0005377_hearing/vestibular/ear_phenot2.17863877
23MP0003878_abnormal_ear_physiology2.17863877
24MP0001819_abnormal_immune_cell2.15842020
25MP0003941_abnormal_skin_development2.13843162
26MP0005025_abnormal_response_to2.10131118
27MP0002723_abnormal_immune_serum2.05224224
28MP0004808_abnormal_hematopoietic_stem2.02184254
29MP0005275_abnormal_skin_tensile2.00775923
30MP0005464_abnormal_platelet_physiology1.96266132
31MP0005000_abnormal_immune_tolerance1.95421883
32MP0002722_abnormal_immune_system1.93718007
33MP0000703_abnormal_thymus_morphology1.93617911
34MP0003436_decreased_susceptibility_to1.90650739
35MP0002452_abnormal_antigen_presenting1.89929150
36MP0002006_tumorigenesis1.89433856
37MP0005075_abnormal_melanosome_morpholog1.88160595
38MP0002148_abnormal_hypersensitivity_rea1.87074355
39MP0001216_abnormal_epidermal_layer1.86572729
40MP0000716_abnormal_immune_system1.85905214
41MP0000689_abnormal_spleen_morphology1.82824108
42MP0003724_increased_susceptibility_to1.81788782
43MP0004957_abnormal_blastocyst_morpholog1.66452967
44MP0002429_abnormal_blood_cell1.65352394
45MP0000490_abnormal_crypts_of1.63483048
46MP0000647_abnormal_sebaceous_gland1.62172092
47MP0002405_respiratory_system_inflammati1.61819746
48MP0001790_abnormal_immune_system1.60952085
49MP0005387_immune_system_phenotype1.60952085
50MP0010155_abnormal_intestine_physiology1.59265986
51MP0003011_delayed_dark_adaptation1.58935990
52MP0001545_abnormal_hematopoietic_system1.57704983
53MP0005397_hematopoietic_system_phenotyp1.57704983
54MP0002095_abnormal_skin_pigmentation1.57548541
55MP0001853_heart_inflammation1.51368991
56MP0001873_stomach_inflammation1.50970693
57MP0010771_integument_phenotype1.49891523
58MP0003866_abnormal_defecation1.43828852
59MP0005174_abnormal_tail_pigmentation1.41960450
60MP0010386_abnormal_urinary_bladder1.40675843
61MP0008007_abnormal_cellular_replicative1.38828497
62MP0002060_abnormal_skin_morphology1.35698123
63MP0010094_abnormal_chromosome_stability1.35059984
64MP0000427_abnormal_hair_cycle1.33319451
65MP0005409_darkened_coat_color1.32963619
66MP0004272_abnormal_basement_membrane1.30513688
67MP0001188_hyperpigmentation1.29876135
68MP0003453_abnormal_keratinocyte_physiol1.29665157
69MP0000858_altered_metastatic_potential1.25429895
70MP0003705_abnormal_hypodermis_morpholog1.25062509
71MP0004885_abnormal_endolymph1.23624124
72MP0002419_abnormal_innate_immunity1.22026456
73MP0001851_eye_inflammation1.21757063
74MP0004782_abnormal_surfactant_physiolog1.21738174
75MP0003693_abnormal_embryo_hatching1.21398267
76MP0002019_abnormal_tumor_incidence1.19403078
77MP0002933_joint_inflammation1.19338341
78MP0003806_abnormal_nucleotide_metabolis1.17135943
79MP0004019_abnormal_vitamin_homeostasis1.15949671
80MP0000383_abnormal_hair_follicle1.15923509
81MP0009931_abnormal_skin_appearance1.13439722
82MP0008057_abnormal_DNA_replication1.11978836
83MP0002009_preneoplasia1.11259690
84MP0003077_abnormal_cell_cycle1.11079605
85MP0001191_abnormal_skin_condition1.10930652
86MP0010030_abnormal_orbit_morphology1.10577583
87MP0010352_gastrointestinal_tract_polyps1.10245850
88MP0009053_abnormal_anal_canal1.07011914
89MP0005451_abnormal_body_composition1.06710161
90MP0000377_abnormal_hair_follicle1.06135913
91MP0006054_spinal_hemorrhage1.05801725
92MP0001845_abnormal_inflammatory_respons1.05474797
93MP0006082_CNS_inflammation0.99546169
94MP0008058_abnormal_DNA_repair0.98614798
95MP0002132_abnormal_respiratory_system0.97202983
96MP0004133_heterotaxia0.97099792
97MP0005023_abnormal_wound_healing0.96630856
98MP0010368_abnormal_lymphatic_system0.95778413
99MP0003566_abnormal_cell_adhesion0.95333789
100MP0000579_abnormal_nail_morphology0.92945168
101MP0002098_abnormal_vibrissa_morphology0.91850109
102MP0000537_abnormal_urethra_morphology0.89679090
103MP0001879_abnormal_lymphatic_vessel0.89299629
104MP0000367_abnormal_coat/_hair0.88614890
105MP0000678_abnormal_parathyroid_gland0.86736677
106MP0010678_abnormal_skin_adnexa0.85496277
107MP0003786_premature_aging0.83177314
108MP0002234_abnormal_pharynx_morphology0.81806159
109MP0004510_myositis0.81786477
110MP0001243_abnormal_dermal_layer0.80240975
111MP0003191_abnormal_cellular_cholesterol0.79215421
112MP0003950_abnormal_plasma_membrane0.78243835
113MP0000627_abnormal_mammary_gland0.78236889
114MP0003315_abnormal_perineum_morphology0.78181406
115MP0003111_abnormal_nucleus_morphology0.76436488
116MP0002111_abnormal_tail_morphology0.73568762
117MP0003448_altered_tumor_morphology0.72392453
118MP0008469_abnormal_protein_level0.72207955
119MP0000467_abnormal_esophagus_morphology0.71070606
120MP0004185_abnormal_adipocyte_glucose0.70085138
121MP0003186_abnormal_redox_activity0.69318851
122MP0006035_abnormal_mitochondrial_morpho0.68592332
123MP0002254_reproductive_system_inflammat0.68359011
124MP0001340_abnormal_eyelid_morphology0.67195780
125MP0001533_abnormal_skeleton_physiology0.67130823
126MP0008932_abnormal_embryonic_tissue0.66919681
127MP0003136_yellow_coat_color0.65079835
128MP0006292_abnormal_olfactory_placode0.64662728
129MP0002177_abnormal_outer_ear0.64656230
130MP0003718_maternal_effect0.62775209
131MP0009780_abnormal_chondrocyte_physiolo0.57482701
132MP0003755_abnormal_palate_morphology0.55191734
133MP0002697_abnormal_eye_size0.54585333
134MP0001849_ear_inflammation0.53149154
135MP0003638_abnormal_response/metabolism_0.52193359
136MP0004043_abnormal_pH_regulation0.51818051
137MP0002282_abnormal_trachea_morphology0.50992344
138MP0005257_abnormal_intraocular_pressure0.46398157
139MP0005076_abnormal_cell_differentiation0.45776995
140MP0001784_abnormal_fluid_regulation0.45027740
141MP0008260_abnormal_autophagy0.44477042
142MP0000350_abnormal_cell_proliferation0.42069018
143MP0009672_abnormal_birth_weight0.39200608
144MP0008875_abnormal_xenobiotic_pharmacok0.38963054
145MP0001730_embryonic_growth_arrest0.37010132
146MP0005193_abnormal_anterior_eye0.36479702
147MP0001881_abnormal_mammary_gland0.34976036
148MP0001485_abnormal_pinna_reflex0.34176440
149MP0008789_abnormal_olfactory_epithelium0.33719638
150MP0004197_abnormal_fetal_growth/weight/0.33360384
151MP0003937_abnormal_limbs/digits/tail_de0.31658841
152MP0002233_abnormal_nose_morphology0.30831806
153MP0004742_abnormal_vestibular_system0.29084747
154MP0001286_abnormal_eye_development0.27876450
155MP0005410_abnormal_fertilization0.27776152
156MP0000358_abnormal_cell_content/0.26422330
157MP0002080_prenatal_lethality0.26005391
158MP0000049_abnormal_middle_ear0.25991410
159MP0002089_abnormal_postnatal_growth/wei0.25195894

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)6.06325995
2Abnormality of cells of the erythroid lineage (HP:0012130)5.53489087
3Elevated erythrocyte sedimentation rate (HP:0003565)5.52895466
4Reticulocytopenia (HP:0001896)5.38550781
5Thick nail (HP:0001805)5.26648484
6Increased IgE level (HP:0003212)5.10940410
7Abnormal number of erythroid precursors (HP:0012131)5.08497986
8Right ventricular cardiomyopathy (HP:0011663)5.05814810
9Thrombocytosis (HP:0001894)4.58715354
10Corneal erosion (HP:0200020)4.44237309
11Parakeratosis (HP:0001036)4.41144171
12Erythema (HP:0010783)4.39341979
13IgM deficiency (HP:0002850)4.13788779
14Lip pit (HP:0100267)3.81996150
15Myositis (HP:0100614)3.80493276
16Macrocytic anemia (HP:0001972)3.80252243
17Pallor (HP:0000980)3.64100051
18Palmoplantar keratoderma (HP:0000982)3.63725585
19Absent eyelashes (HP:0000561)3.56725336
20Hypotrichosis (HP:0001006)3.45337729
21Hypohidrosis (HP:0000966)3.40914765
22Abnormal hair laboratory examination (HP:0003328)3.37704539
23Oral leukoplakia (HP:0002745)3.34599262
24Woolly hair (HP:0002224)3.33669840
25Gangrene (HP:0100758)3.32845763
26Aplastic anemia (HP:0001915)3.31473686
27Abnormality of the salivary glands (HP:0010286)3.26950879
28Abnormality of placental membranes (HP:0011409)3.25586456
29Amniotic constriction ring (HP:0009775)3.25586456
30T lymphocytopenia (HP:0005403)3.25509130
31Chronic otitis media (HP:0000389)3.23443283
32Severe combined immunodeficiency (HP:0004430)3.09649561
33Panhypogammaglobulinemia (HP:0003139)3.07771708
34Abnormality of T cells (HP:0002843)3.07062710
35Abnormality of T cell number (HP:0011839)3.06092707
36Absent hair (HP:0002298)3.04208730
37Onycholysis (HP:0001806)3.02350166
38Abnormality of nail color (HP:0100643)3.01084460
3911 pairs of ribs (HP:0000878)3.01017328
40Recurrent bronchitis (HP:0002837)3.00446591
41Abnormality of the nasal mucosa (HP:0000433)2.96096222
42Hypergammaglobulinemia (HP:0010702)2.95842198
43Petechiae (HP:0000967)2.95566749
44Selective tooth agenesis (HP:0001592)2.91969659
45Colon cancer (HP:0003003)2.89947197
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86610939
47IgG deficiency (HP:0004315)2.84047972
48Congenital ichthyosiform erythroderma (HP:0007431)2.82900583
49Prolonged bleeding time (HP:0003010)2.82507324
50Autoimmune hemolytic anemia (HP:0001890)2.81784685
51Nasal polyposis (HP:0100582)2.80641047
52Plantar hyperkeratosis (HP:0007556)2.74122051
53Combined immunodeficiency (HP:0005387)2.73207319
54Eczematoid dermatitis (HP:0000976)2.70060286
55Muscle fiber atrophy (HP:0100295)2.67426369
56Sparse eyelashes (HP:0000653)2.65569989
57Palmoplantar hyperkeratosis (HP:0000972)2.65067103
58Erythroderma (HP:0001019)2.62316732
59Follicular hyperkeratosis (HP:0007502)2.61758240
60Abnormality of T cell physiology (HP:0011840)2.60037661
61Autoamputation (HP:0001218)2.59059211
62Atrophic scars (HP:0001075)2.53451250
63Nasolacrimal duct obstruction (HP:0000579)2.53144511
64Type 2 muscle fiber atrophy (HP:0003554)2.52096925
65Palmar hyperkeratosis (HP:0010765)2.48970327
66Asplenia (HP:0001746)2.43778898
67Abnormality of secondary sexual hair (HP:0009888)2.43010061
68Abnormality of the axillary hair (HP:0100134)2.43010061
69Thyroiditis (HP:0100646)2.42088545
70Hypoplastic labia majora (HP:0000059)2.40329384
71Congenital, generalized hypertrichosis (HP:0004540)2.39497045
72Blepharitis (HP:0000498)2.38772208
73Stomatitis (HP:0010280)2.36985694
74Abnormal blistering of the skin (HP:0008066)2.36505973
75Lymphopenia (HP:0001888)2.33928788
76Ectropion (HP:0000656)2.33324044
77Epistaxis (HP:0000421)2.31935783
78Conjunctival hamartoma (HP:0100780)2.31463905
79Brittle hair (HP:0002299)2.29643410
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.28125476
81Recurrent viral infections (HP:0004429)2.26702373
82Fragile nails (HP:0001808)2.26207348
83Keratoconjunctivitis sicca (HP:0001097)2.25242345
84Pili torti (HP:0003777)2.25098711
85Impaired platelet aggregation (HP:0003540)2.25072711
86Abnormal platelet function (HP:0011869)2.25072711
87Basal cell carcinoma (HP:0002671)2.23435572
88Hypoproteinemia (HP:0003075)2.21641192
89Recurrent fungal infections (HP:0002841)2.19339730
90Aplasia cutis congenita (HP:0001057)2.15868915
91Aplasia/Hypoplasia of the spleen (HP:0010451)2.15773322
92Pruritus (HP:0000989)2.15129136
93Abnormality of the labia majora (HP:0012881)2.15009669
94Abnormality of B cell number (HP:0010975)2.14358447
95B lymphocytopenia (HP:0010976)2.14358447
96Abnormality of the lacrimal duct (HP:0011481)2.13545780
97Hyperhidrosis (HP:0000975)2.13055934
98Anonychia (HP:0001798)2.12580703
99Orchitis (HP:0100796)2.11432463
100Granulocytopenia (HP:0001913)2.11050165
101Amaurosis fugax (HP:0100576)2.09594274
102Furrowed tongue (HP:0000221)2.09578994
103Skin ulcer (HP:0200042)2.08344519
104Dry hair (HP:0011359)2.06529594
105Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06471016
106Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06343436
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06343436
108Lymphoma (HP:0002665)2.06271867
109Spontaneous hematomas (HP:0007420)2.05731558
110Trismus (HP:0000211)2.05419029
111Purpura (HP:0000979)2.04145649
112Dehydration (HP:0001944)2.03897111
113Migraine (HP:0002076)2.02654464
114Popliteal pterygium (HP:0009756)2.02249012
115Abnormality of the dental root (HP:0006486)2.01718845
116Taurodontia (HP:0000679)2.01718845
117Abnormality of permanent molar morphology (HP:0011071)2.01718845
118Pterygium (HP:0001059)2.01649629
119Keratoconjunctivitis (HP:0001096)2.01484184
120Nail dystrophy (HP:0008404)2.01424514
121Pustule (HP:0200039)2.00101212
122Abnormality of eosinophils (HP:0001879)1.99788469
123Hypoplasia of the thymus (HP:0000778)1.99263391
124Natal tooth (HP:0000695)1.98440084
125Microcytic anemia (HP:0001935)1.96917754
126Pancytopenia (HP:0001876)1.96008682
127Abnormality of the prostate (HP:0008775)1.95277973
128Carious teeth (HP:0000670)1.93166997
129Leukocytosis (HP:0001974)1.92051016
130Ridged nail (HP:0001807)1.91776323
131Milia (HP:0001056)1.91774218
132Recurrent cutaneous fungal infections (HP:0011370)1.91568773
133Chronic mucocutaneous candidiasis (HP:0002728)1.91568773
134Increased hepatocellular lipid droplets (HP:0006565)1.90600231
135Chronic diarrhea (HP:0002028)1.90003606
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.89900452
137Type I transferrin isoform profile (HP:0003642)1.89639377
138Sparse scalp hair (HP:0002209)1.89608779
139Corneal dystrophy (HP:0001131)1.89228683
140Acanthosis nigricans (HP:0000956)1.87477293
141Abnormality of molar (HP:0011077)1.84426250
142Abnormality of molar morphology (HP:0011070)1.84426250
143Hypoplasia of the uterus (HP:0000013)1.83631181
144Abnormality of the nasolacrimal system (HP:0000614)1.83283904
145Multifactorial inheritance (HP:0001426)1.82898085
146Recurrent corneal erosions (HP:0000495)1.81778293
147Abnormality of the dental pulp (HP:0006479)1.79547660
148Split foot (HP:0001839)1.76274030
149Advanced eruption of teeth (HP:0006288)1.73381622
150Hamartoma of the eye (HP:0010568)1.72506296
151Amelogenesis imperfecta (HP:0000705)1.71197973
152Aplasia/hypoplasia of the uterus (HP:0008684)1.68050069
153Stenosis of the external auditory canal (HP:0000402)1.65733366
154Abnormality of the fingernails (HP:0001231)1.62823673
155Squamous cell carcinoma (HP:0002860)1.62675355
156Ventricular tachycardia (HP:0004756)1.59952350
157Hoarse voice (HP:0001609)1.58624826
158Hypoplastic female external genitalia (HP:0012815)1.58114562
159Lack of skin elasticity (HP:0100679)1.57850209
160Laryngomalacia (HP:0001601)1.56675562
161Labial hypoplasia (HP:0000066)1.55666961
162Abnormality of small intestinal villus morphology (HP:0011472)1.52851472
163Villous atrophy (HP:0011473)1.52851472
164Abnormalities of placenta or umbilical cord (HP:0001194)1.49385271
165Conical tooth (HP:0000698)1.47323467
166Abnormality of the neuromuscular junction (HP:0003398)1.46945445
167Fatigable weakness (HP:0003473)1.46945445
168Hypoplasia of dental enamel (HP:0006297)1.46574800
169Abnormality of the lower motor neuron (HP:0002366)1.45231726
170Ankle contracture (HP:0006466)1.43958818
171Curly hair (HP:0002212)1.43842573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.39656009
2NME24.27115084
3MST1R4.17366118
4MAP4K13.96475217
5TXK3.71093602
6PBK3.44349412
7KDR3.00578806
8ZAP702.50330670
9TEC2.43083474
10MAP3K122.42919045
11VRK22.36571765
12MET2.29786465
13LATS12.26606044
14STK162.17215487
15BTK2.09731827
16KIT2.07101671
17RPS6KB22.06562464
18MAP3K21.96575855
19TGFBR21.96156905
20TGFBR11.92996388
21ITK1.92009070
22MAPKAPK31.87431052
23EEF2K1.83859648
24LATS21.82164749
25BLK1.81920500
26JAK31.79353849
27FER1.76053114
28TIE11.74793005
29FLT31.74713503
30SYK1.63644835
31CDK191.57788816
32GRK61.57228580
33TTK1.54961637
34WEE11.49197661
35MST41.48207139
36IKBKE1.46362384
37MAP2K31.45994217
38LRRK21.45186057
39LCK1.43745875
40TBK11.39873849
41ABL21.39153578
42PIM21.38877406
43PTK21.37570539
44TYK21.33199859
45STK101.30490758
46NLK1.30233864
47MAP3K91.28958065
48RPS6KA41.28142684
49MAP2K61.27884717
50FGFR11.23194482
51STK38L1.22935320
52EPHB21.19770238
53RIPK41.17219288
54BUB11.16588804
55MAP3K61.15016543
56MUSK1.14803870
57VRK11.14679955
58MAP3K111.13599764
59FES1.11628555
60CDC71.09322907
61TNK21.05341584
62LYN1.05239144
63MAP3K31.02750534
64PDK21.00270534
65CLK10.99720183
66NEK10.99451338
67MAPK150.98686088
68NTRK10.97021295
69SRPK10.96610920
70ARAF0.94765803
71IKBKB0.93727626
72ADRBK20.92631354
73CSF1R0.91655044
74BMX0.90838035
75MAP3K130.90460861
76ACVR1B0.86856442
77HCK0.86292954
78TSSK60.85642223
79ILK0.85411121
80PRKCI0.84697391
81PASK0.81296865
82DYRK30.80351741
83RAF10.77151889
84FGFR40.75632707
85DAPK10.72395237
86MYLK0.72285553
87TAF10.71148442
88NME10.70300119
89ERN10.69718976
90CDK70.68103411
91TLK10.67236850
92SIK10.66139842
93PRKG20.64603311
94TNIK0.64497113
95PIM10.64394641
96EIF2AK30.64188240
97CDK80.63908451
98PLK10.63589088
99PAK40.61756291
100GRK70.61059830
101AURKB0.58131195
102EPHB10.57888116
103MAP3K100.57130881
104NEK60.56397469
105STK30.55167086
106CDK40.55032866
107MKNK10.53521190
108SMG10.53516176
109PKN20.52460758
110SCYL20.51128927
111IRAK40.50991053
112MAP3K140.50158463
113GRK10.49212544
114PLK30.49054723
115STK380.46516167
116MATK0.46395284
117BCKDK0.46189411
118EIF2AK10.44154816
119GRK50.44153707
120ATR0.43175622
121PLK40.42426822
122PIK3CG0.42310992
123IRAK10.41036778
124DDR20.38717325
125PRKD20.38597333
126CHEK20.38319991
127MAP3K80.38013961
128ADRBK10.38011983
129PTK60.37481966
130LMTK20.37218357
131CDK90.37091627
132NUAK10.36496230
133MAPKAPK20.36096976
134CSNK2A20.35628277
135MAP3K70.35363824
136SIK30.35280782
137CAMK2G0.34984940
138MAPK120.34784666
139TAOK20.34214936
140EIF2AK20.33943235
141STK240.33909715
142PRKCQ0.33785955
143CSNK2A10.33675908
144CSK0.33372782
145CSNK1E0.32545634
146TESK10.31924587
147IRAK20.31307616
148MAPKAPK50.29519619
149RPS6KA60.29330231
150NEK20.29055951
151MTOR0.28848923
152CHEK10.28132716
153AURKA0.27528074
154PRKCD0.27403848
155TAOK10.26310384
156DMPK0.25316408
157ROCK20.24968237
158MAP3K10.23494356
159ALK0.21106190
160EPHA30.20336646
161AKT20.20124876

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.17425724
2DNA replication_Homo sapiens_hsa030303.51376381
3Primary immunodeficiency_Homo sapiens_hsa053403.42121250
4Proteasome_Homo sapiens_hsa030502.80448840
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.65521451
6Mismatch repair_Homo sapiens_hsa034302.58299702
7Fatty acid elongation_Homo sapiens_hsa000622.55220231
8RNA polymerase_Homo sapiens_hsa030202.36060251
9Sphingolipid metabolism_Homo sapiens_hsa006002.31340219
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24352335
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15127310
12Spliceosome_Homo sapiens_hsa030402.12264888
13Linoleic acid metabolism_Homo sapiens_hsa005912.11244253
14Base excision repair_Homo sapiens_hsa034102.08656985
15Antigen processing and presentation_Homo sapiens_hsa046122.06952809
16Ether lipid metabolism_Homo sapiens_hsa005651.84358188
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83899658
18Graft-versus-host disease_Homo sapiens_hsa053321.81674580
19T cell receptor signaling pathway_Homo sapiens_hsa046601.81003872
20Nucleotide excision repair_Homo sapiens_hsa034201.80281492
21Pyrimidine metabolism_Homo sapiens_hsa002401.78421835
22Allograft rejection_Homo sapiens_hsa053301.75419767
23Hematopoietic cell lineage_Homo sapiens_hsa046401.75210082
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74579813
25Measles_Homo sapiens_hsa051621.66431023
26Homologous recombination_Homo sapiens_hsa034401.62875452
27Pyruvate metabolism_Homo sapiens_hsa006201.42680757
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38890477
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.37857073
30RNA degradation_Homo sapiens_hsa030181.33011119
31Phenylalanine metabolism_Homo sapiens_hsa003601.32450938
32Herpes simplex infection_Homo sapiens_hsa051681.32221439
33Glutathione metabolism_Homo sapiens_hsa004801.31909255
34Non-homologous end-joining_Homo sapiens_hsa034501.28825791
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28297029
36B cell receptor signaling pathway_Homo sapiens_hsa046621.27487477
37Histidine metabolism_Homo sapiens_hsa003401.27291987
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.24483414
39Leishmaniasis_Homo sapiens_hsa051401.22419615
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22145516
41RNA transport_Homo sapiens_hsa030131.20371748
42Galactose metabolism_Homo sapiens_hsa000521.20033307
43Shigellosis_Homo sapiens_hsa051311.19322088
44Vitamin B6 metabolism_Homo sapiens_hsa007501.17988376
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17350900
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.14891739
47Tight junction_Homo sapiens_hsa045301.14686269
48Retinol metabolism_Homo sapiens_hsa008301.12380435
49p53 signaling pathway_Homo sapiens_hsa041151.12175416
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06614633
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06090105
52Platelet activation_Homo sapiens_hsa046111.04091316
53Protein export_Homo sapiens_hsa030601.03585709
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01600262
55ECM-receptor interaction_Homo sapiens_hsa045120.98217871
56Long-term depression_Homo sapiens_hsa047300.97948097
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96106025
58Cardiac muscle contraction_Homo sapiens_hsa042600.95924477
59Autoimmune thyroid disease_Homo sapiens_hsa053200.91733733
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91593831
61Asthma_Homo sapiens_hsa053100.91175897
62Acute myeloid leukemia_Homo sapiens_hsa052210.91169697
63Epstein-Barr virus infection_Homo sapiens_hsa051690.89329644
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88300640
65Fructose and mannose metabolism_Homo sapiens_hsa000510.88060782
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.87000277
67Cell cycle_Homo sapiens_hsa041100.86779631
68Purine metabolism_Homo sapiens_hsa002300.86422149
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.86201268
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85858346
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85412615
72Osteoclast differentiation_Homo sapiens_hsa043800.85389154
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.84561909
74VEGF signaling pathway_Homo sapiens_hsa043700.84450152
75Biosynthesis of amino acids_Homo sapiens_hsa012300.83806127
76Vitamin digestion and absorption_Homo sapiens_hsa049770.83799927
77Thyroid cancer_Homo sapiens_hsa052160.80830454
78Basal transcription factors_Homo sapiens_hsa030220.79941268
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.79420766
80HTLV-I infection_Homo sapiens_hsa051660.79163622
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78187101
82Phototransduction_Homo sapiens_hsa047440.77969321
83Pertussis_Homo sapiens_hsa051330.77842850
84Metabolic pathways_Homo sapiens_hsa011000.77642703
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77575388
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76797096
87Arginine and proline metabolism_Homo sapiens_hsa003300.76720452
88Fanconi anemia pathway_Homo sapiens_hsa034600.76372316
89Hepatitis B_Homo sapiens_hsa051610.74682010
90Chemical carcinogenesis_Homo sapiens_hsa052040.74040775
91Viral myocarditis_Homo sapiens_hsa054160.72608373
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71909807
93Adherens junction_Homo sapiens_hsa045200.71089235
94Toxoplasmosis_Homo sapiens_hsa051450.69391397
95Sulfur metabolism_Homo sapiens_hsa009200.67861840
96Glycerolipid metabolism_Homo sapiens_hsa005610.67598710
97Legionellosis_Homo sapiens_hsa051340.67598550
98Mineral absorption_Homo sapiens_hsa049780.67596743
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.67008896
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66138831
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65666755
102Collecting duct acid secretion_Homo sapiens_hsa049660.63740933
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62735013
104Influenza A_Homo sapiens_hsa051640.61717573
105beta-Alanine metabolism_Homo sapiens_hsa004100.61504965
106Apoptosis_Homo sapiens_hsa042100.61485463
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.61384142
108Steroid biosynthesis_Homo sapiens_hsa001000.61258182
109Pentose phosphate pathway_Homo sapiens_hsa000300.59783539
110Tyrosine metabolism_Homo sapiens_hsa003500.59461252
111Nitrogen metabolism_Homo sapiens_hsa009100.59379085
112Parkinsons disease_Homo sapiens_hsa050120.58827972
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57853373
114Arginine biosynthesis_Homo sapiens_hsa002200.57435238
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.57334284
116Malaria_Homo sapiens_hsa051440.56216032
117Hippo signaling pathway_Homo sapiens_hsa043900.55371889
118Other glycan degradation_Homo sapiens_hsa005110.55276743
119Amoebiasis_Homo sapiens_hsa051460.54979385
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54104589
121Ovarian steroidogenesis_Homo sapiens_hsa049130.51607420
122TGF-beta signaling pathway_Homo sapiens_hsa043500.51323182
123Alzheimers disease_Homo sapiens_hsa050100.50355649
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49910110
125Salmonella infection_Homo sapiens_hsa051320.48504405
126Oxidative phosphorylation_Homo sapiens_hsa001900.48061886
127Carbon metabolism_Homo sapiens_hsa012000.47172433
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46676065
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46270910
130Serotonergic synapse_Homo sapiens_hsa047260.45332951
131Vibrio cholerae infection_Homo sapiens_hsa051100.45313267
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45224080
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44606022
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43930395
135Arachidonic acid metabolism_Homo sapiens_hsa005900.43870036
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43069777
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43001284
138Folate biosynthesis_Homo sapiens_hsa007900.42992238
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42865333
140One carbon pool by folate_Homo sapiens_hsa006700.42234735
141Sulfur relay system_Homo sapiens_hsa041220.42131704
142Chemokine signaling pathway_Homo sapiens_hsa040620.41807319
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41708688
144Oocyte meiosis_Homo sapiens_hsa041140.41674174
145Viral carcinogenesis_Homo sapiens_hsa052030.39167827
146Huntingtons disease_Homo sapiens_hsa050160.37950231
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36957925
148Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36817753
149TNF signaling pathway_Homo sapiens_hsa046680.35717820
150Tuberculosis_Homo sapiens_hsa051520.33769955
151Small cell lung cancer_Homo sapiens_hsa052220.33624268
152Colorectal cancer_Homo sapiens_hsa052100.32176146
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30629051
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30223787
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.30151406
156Starch and sucrose metabolism_Homo sapiens_hsa005000.29923032
157Hepatitis C_Homo sapiens_hsa051600.29754543
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29728116
159mRNA surveillance pathway_Homo sapiens_hsa030150.28677353
160Rap1 signaling pathway_Homo sapiens_hsa040150.28591651
161Type I diabetes mellitus_Homo sapiens_hsa049400.28126338
162Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28023563
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27309607
164African trypanosomiasis_Homo sapiens_hsa051430.26849436
165N-Glycan biosynthesis_Homo sapiens_hsa005100.25854877
166Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25590990

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