KLK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)9.59230572
2multicellular organismal water homeostasis (GO:0050891)9.22566221
3intermediate filament organization (GO:0045109)7.99832591
4skin morphogenesis (GO:0043589)7.70405939
5water homeostasis (GO:0030104)7.64432641
6epidermal cell differentiation (GO:0009913)7.22320549
7epidermis development (GO:0008544)7.20944234
8ectoderm development (GO:0007398)6.88586044
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.42207033
10fatty acid elongation (GO:0030497)5.84134155
11intermediate filament cytoskeleton organization (GO:0045104)5.83087402
12long-chain fatty acid biosynthetic process (GO:0042759)5.77166446
13intermediate filament-based process (GO:0045103)5.66760897
14keratinocyte proliferation (GO:0043616)4.88498774
15keratinocyte development (GO:0003334)4.43714957
16linoleic acid metabolic process (GO:0043651)3.93263815
17fibrinolysis (GO:0042730)3.82050760
18skin development (GO:0043588)3.79158300
19virion attachment to host cell (GO:0019062)3.74815542
20adhesion of symbiont to host cell (GO:0044650)3.74815542
21cell-substrate junction assembly (GO:0007044)3.72171392
22lipoxygenase pathway (GO:0019372)3.43312630
23negative regulation of cell fate specification (GO:0009996)3.39067738
24glucosamine-containing compound catabolic process (GO:1901072)3.37819971
25epithelium development (GO:0060429)3.34188355
26phosphatidylinositol acyl-chain remodeling (GO:0036149)3.30093620
27detection of bacterium (GO:0016045)3.21610748
28regulation of ruffle assembly (GO:1900027)3.21396827
29long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.18427786
30atrioventricular valve morphogenesis (GO:0003181)3.09452428
31adhesion of symbiont to host (GO:0044406)3.08233704
32response to zinc ion (GO:0010043)3.03344827
33long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.02456261
34keratinization (GO:0031424)23.1328753
35phosphatidylserine acyl-chain remodeling (GO:0036150)2.96777208
36positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.96696009
37positive regulation of monocyte chemotaxis (GO:0090026)2.91478339
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90637548
39negative regulation of keratinocyte proliferation (GO:0010839)2.89223703
40regulation of cardioblast differentiation (GO:0051890)2.88597429
41eyelid development in camera-type eye (GO:0061029)2.78054687
42detection of other organism (GO:0098543)2.77112666
43fatty-acyl-CoA biosynthetic process (GO:0046949)2.75905958
44positive regulation of epidermis development (GO:0045684)2.71978420
45positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.71239684
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68611466
47regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68026454
48ventricular cardiac muscle cell action potential (GO:0086005)2.66073734
49fatty-acyl-CoA metabolic process (GO:0035337)2.60727336
50sphingoid metabolic process (GO:0046519)2.59615916
51establishment of planar polarity (GO:0001736)2.57887138
52establishment of tissue polarity (GO:0007164)2.57887138
53wound healing (GO:0042060)2.56898225
54positive regulation of epidermal cell differentiation (GO:0045606)2.55009103
55protein localization to endosome (GO:0036010)2.50694127
56surfactant homeostasis (GO:0043129)2.48530989
57negative regulation of stress fiber assembly (GO:0051497)2.48487778
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.47319346
59sphingosine metabolic process (GO:0006670)2.46709624
60negative regulation of cell fate commitment (GO:0010454)2.44821382
61epithelial cell-cell adhesion (GO:0090136)2.41929965
62very long-chain fatty acid metabolic process (GO:0000038)2.40357476
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.37694777
64regulation of keratinocyte differentiation (GO:0045616)2.35901956
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.33782016
66regulation of monocyte chemotaxis (GO:0090025)2.31678119
67regulation of epidermis development (GO:0045682)2.31509466
68gap junction assembly (GO:0016264)2.29774028
69actin-myosin filament sliding (GO:0033275)2.28359188
70muscle filament sliding (GO:0030049)2.28359188
71chemical homeostasis within a tissue (GO:0048875)2.21117963
72diol metabolic process (GO:0034311)2.20874623
73cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.20448501
74phospholipid efflux (GO:0033700)2.19949160
75gland morphogenesis (GO:0022612)2.19683173
76regulation of heart rate by cardiac conduction (GO:0086091)2.13240191
77regulation of hair cycle (GO:0042634)2.12584772
78hair follicle morphogenesis (GO:0031069)2.11665734
79hormone catabolic process (GO:0042447)2.11375361
80acyl-CoA biosynthetic process (GO:0071616)2.10423265
81thioester biosynthetic process (GO:0035384)2.10423265
82negative regulation of heart growth (GO:0061117)2.08303890
83negative regulation of cardiac muscle tissue growth (GO:0055022)2.08303890
84epithelial cell differentiation (GO:0030855)2.07898508
85positive regulation of hair follicle development (GO:0051798)2.06238430
86positive regulation of hair cycle (GO:0042635)2.06238430
87regulation of neuron projection regeneration (GO:0070570)2.04747634
88regulation of axon regeneration (GO:0048679)2.04747634
89regulation of chemokine secretion (GO:0090196)2.04705360
90amyloid precursor protein metabolic process (GO:0042982)2.04110650
91phosphatidylserine metabolic process (GO:0006658)2.03123824
92regulation of natural killer cell differentiation (GO:0032823)2.02100475
93regulation of epidermal cell differentiation (GO:0045604)2.01234080
94establishment of skin barrier (GO:0061436)16.2656582
95hair cycle (GO:0042633)14.6829887
96molting cycle (GO:0042303)14.6829887
97regulation of water loss via skin (GO:0033561)14.2130902
98desmosome organization (GO:0002934)13.2720157
99hemidesmosome assembly (GO:0031581)10.6337474
100peptide cross-linking (GO:0018149)10.2417424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.98654162
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.31297550
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88566675
4ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.56449597
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49685256
6ZNF263_19887448_ChIP-Seq_K562_Human2.17202076
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.16170990
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.11330343
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.11330343
10SOX9_24532713_ChIP-Seq_HFSC_Mouse2.01614635
11TP63_17297297_ChIP-ChIP_HaCaT_Human15.5836246
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78089953
13EGR1_19032775_ChIP-ChIP_M12_Human1.77084540
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.72393430
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.67650786
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.55196181
17GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.53960085
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49243226
19AR_21572438_ChIP-Seq_LNCaP_Human1.45852549
20ATF3_27146783_Chip-Seq_COLON_Human1.44759954
21TP63_23658742_ChIP-Seq_EP156T_Human1.37595376
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35864669
23RACK7_27058665_Chip-Seq_MCF-7_Human1.35621728
24GATA6_21074721_ChIP-Seq_CACO-2_Human1.33739266
25SOX2_20726797_ChIP-Seq_SW620_Human1.32044936
26TP63_22573176_ChIP-Seq_HFKS_Human1.31976502
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31785586
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30987455
29RXR_22108803_ChIP-Seq_LS180_Human1.26318667
30GATA3_24758297_ChIP-Seq_MCF-7_Human1.24333947
31CTCF_27219007_Chip-Seq_Bcells_Human1.22887783
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20655698
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20623929
34CJUN_26792858_Chip-Seq_BT549_Human1.20427319
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18352889
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18234625
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17090446
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15989717
39CTCF_20526341_ChIP-Seq_ESCs_Human1.15821356
40P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13690129
41ERG_20517297_ChIP-Seq_VCAP_Human1.10871930
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10281426
43E2F1_20622854_ChIP-Seq_HELA_Human1.09482991
44LXR_22292898_ChIP-Seq_THP-1_Human1.06993025
45BCOR_27268052_Chip-Seq_Bcells_Human1.06681789
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06226077
47KLF5_25053715_ChIP-Seq_YYC3_Human1.06111001
48TP53_18474530_ChIP-ChIP_U2OS_Human1.04753530
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.04712204
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03234357
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.03215784
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03183150
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02634518
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02539752
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.01792886
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.00850087
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98546742
58NANOG_20526341_ChIP-Seq_ESCs_Human0.98177942
59SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96733084
60CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93874033
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92652410
62CEBPB_22108803_ChIP-Seq_LS180_Human0.89354728
63ELK3_25401928_ChIP-Seq_HUVEC_Human0.89097511
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87775874
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86140849
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83638901
67YY1_22570637_ChIP-Seq_MALME-3M_Human0.83503226
68TP53_20018659_ChIP-ChIP_R1E_Mouse0.83181293
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.82732341
70CLOCK_20551151_ChIP-Seq_293T_Human0.82710071
71CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81610055
72P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81298994
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79874985
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79520319
75* BCL6_27268052_Chip-Seq_Bcells_Human0.78409291
76P68_20966046_ChIP-Seq_HELA_Human0.77627355
77TAF2_19829295_ChIP-Seq_ESCs_Human0.76883886
78KDM2B_26808549_Chip-Seq_DND41_Human0.76064100
79GATA4_25053715_ChIP-Seq_YYC3_Human0.75959763
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.75794944
81SMC4_20622854_ChIP-Seq_HELA_Human0.73740294
82GATA6_25053715_ChIP-Seq_YYC3_Human0.72241433
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.72171476
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72033754
85SPI1_20517297_ChIP-Seq_HL60_Human0.71574410
86RBPJ_21746931_ChIP-Seq_IB4_Human0.71335625
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.70890318
88JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70599667
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.69728980
90ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68379074
91RAC3_21632823_ChIP-Seq_H3396_Human0.68105935
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67224831
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66832894
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.66646949
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64646445
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.64065898
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.63953271
98KDM2B_26808549_Chip-Seq_K562_Human0.63760699
99AHR_22903824_ChIP-Seq_MCF-7_Human0.63625018
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.63612992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.55959131
2MP0000579_abnormal_nail_morphology6.87291122
3MP0005275_abnormal_skin_tensile6.58994423
4MP0005501_abnormal_skin_physiology5.31880692
5MP0000467_abnormal_esophagus_morphology3.66648283
6MP0010234_abnormal_vibrissa_follicle3.60697591
7MP0001216_abnormal_epidermal_layer3.49298162
8MP0000383_abnormal_hair_follicle3.28421139
9MP0003941_abnormal_skin_development3.26474530
10MP0003705_abnormal_hypodermis_morpholog3.22017268
11MP0004381_abnormal_hair_follicle3.15524888
12MP0002060_abnormal_skin_morphology3.13805109
13MP0010771_integument_phenotype3.11825366
14MP0003453_abnormal_keratinocyte_physiol2.96794525
15MP0004947_skin_inflammation2.89827624
16MP0010678_abnormal_skin_adnexa2.88683923
17MP0000647_abnormal_sebaceous_gland2.65910670
18MP0000762_abnormal_tongue_morphology2.47178407
19MP0000377_abnormal_hair_follicle2.36860999
20MP0002254_reproductive_system_inflammat2.22405341
21MP0002098_abnormal_vibrissa_morphology2.15438311
22MP0005451_abnormal_body_composition2.03144352
23MP0000427_abnormal_hair_cycle2.01694048
24MP0003566_abnormal_cell_adhesion1.90424154
25MP0005409_darkened_coat_color1.82199646
26MP0009931_abnormal_skin_appearance1.79718879
27MP0003191_abnormal_cellular_cholesterol1.68647205
28MP0004185_abnormal_adipocyte_glucose1.59878346
29MP0001191_abnormal_skin_condition1.58670615
30MP0002234_abnormal_pharynx_morphology1.57698995
31MP0001243_abnormal_dermal_layer1.50198836
32MP0001188_hyperpigmentation1.45997228
33MP0000367_abnormal_coat/_hair1.40359181
34MP0008438_abnormal_cutaneous_collagen1.25042611
35MP0000465_gastrointestinal_hemorrhage1.21699510
36MP0005023_abnormal_wound_healing1.15162688
37MP0001851_eye_inflammation1.14600327
38MP0000566_synostosis1.11760884
39MP0002282_abnormal_trachea_morphology1.03237075
40MP0009053_abnormal_anal_canal0.98826164
41MP0001849_ear_inflammation0.88617619
42MP0003950_abnormal_plasma_membrane0.87411952
43MP0003755_abnormal_palate_morphology0.73022258
44MP0001784_abnormal_fluid_regulation0.72059836
45MP0001340_abnormal_eyelid_morphology0.70169028
46MP0004782_abnormal_surfactant_physiolog0.66089698
47MP0010352_gastrointestinal_tract_polyps0.64213212
48MP0001346_abnormal_lacrimal_gland0.61871848
49MP0003436_decreased_susceptibility_to0.54151514
50MP0002095_abnormal_skin_pigmentation0.53664642
51MP0002933_joint_inflammation0.52519315
52MP0002177_abnormal_outer_ear0.52403786
53MP0005666_abnormal_adipose_tissue0.48960723
54MP0000749_muscle_degeneration0.46815465
55MP0001533_abnormal_skeleton_physiology0.41936141
56MP0000751_myopathy0.39435257
57MP0004272_abnormal_basement_membrane0.39395930
58MP0003011_delayed_dark_adaptation0.38816782
59MP0005076_abnormal_cell_differentiation0.37238455
60MP0002111_abnormal_tail_morphology0.36644269
61MP0005375_adipose_tissue_phenotype0.36243581
62MP0003329_amyloid_beta_deposits0.34726305
63MP0001299_abnormal_eye_distance/0.34630055
64MP0004858_abnormal_nervous_system0.32977046
65MP0002877_abnormal_melanocyte_morpholog0.32903636
66MP0000750_abnormal_muscle_regeneration0.32524303
67MP0010030_abnormal_orbit_morphology0.32206488
68MP0004885_abnormal_endolymph0.30943057
69MP0004264_abnormal_extraembryonic_tissu0.30733492
70MP0003315_abnormal_perineum_morphology0.29963896
71MP0000627_abnormal_mammary_gland0.29820537
72MP0001958_emphysema0.29038083
73MP0002896_abnormal_bone_mineralization0.27577232
74MP0003303_peritoneal_inflammation0.25984465
75MP0000733_abnormal_muscle_development0.25866344
76MP0000747_muscle_weakness0.25357431
77MP0005390_skeleton_phenotype0.25275632
78MP0001542_abnormal_bone_strength0.24984545
79MP0000538_abnormal_urinary_bladder0.24198376
80MP0003300_gastrointestinal_ulcer0.24144499
81MP0003448_altered_tumor_morphology0.24003335
82MP0003075_altered_response_to0.23108506
83MP0004197_abnormal_fetal_growth/weight/0.22922618
84MP0002133_abnormal_respiratory_system0.22752370
85MP0005388_respiratory_system_phenotype0.22752370
86MP0003763_abnormal_thymus_physiology0.22556816
87MP0000432_abnormal_head_morphology0.22554379
88MP0005508_abnormal_skeleton_morphology0.22401962
89MP0005193_abnormal_anterior_eye0.22381812
90MP0004087_abnormal_muscle_fiber0.21203087
91MP0000343_altered_response_to0.21039138
92MP0008004_abnormal_stomach_pH0.20289262
93MP0002166_altered_tumor_susceptibility0.20234564
94MP0000759_abnormal_skeletal_muscle0.20016092
95MP0006054_spinal_hemorrhage0.19780939
96MP0008789_abnormal_olfactory_epithelium0.18030734
97MP0002089_abnormal_postnatal_growth/wei0.17521855
98MP0003385_abnormal_body_wall0.16591243
99MP0000604_amyloidosis0.16310858
100MP0001177_atelectasis0.15412934

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)8.82966958
2Increased IgE level (HP:0003212)8.03162257
3Palmoplantar hyperkeratosis (HP:0000972)7.98411761
4Plantar hyperkeratosis (HP:0007556)7.57846790
5Palmar hyperkeratosis (HP:0010765)7.55317552
6Oral leukoplakia (HP:0002745)6.54509056
7Hypotrichosis (HP:0001006)6.46451558
8Onycholysis (HP:0001806)6.08516321
9Alopecia of scalp (HP:0002293)5.87103773
10Follicular hyperkeratosis (HP:0007502)5.82952953
11Conjunctival hamartoma (HP:0100780)5.61568462
12Fragile nails (HP:0001808)5.37188776
13Erythroderma (HP:0001019)5.36608930
14Woolly hair (HP:0002224)5.25893360
15Erythema (HP:0010783)5.19275238
16Milia (HP:0001056)5.02573353
17Congenital ichthyosiform erythroderma (HP:0007431)4.96478176
18Abnormal blistering of the skin (HP:0008066)4.83314766
19Right ventricular cardiomyopathy (HP:0011663)4.52741310
20Pili torti (HP:0003777)4.40046021
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.99838062
22Gangrene (HP:0100758)3.98956763
23Nail dystrophy (HP:0008404)3.95043589
24Palmoplantar keratoderma (HP:0000982)3.65130615
25Hamartoma of the eye (HP:0010568)3.57088815
26Ectropion (HP:0000656)3.56012306
27Laryngomalacia (HP:0001601)3.43057795
28Corneal erosion (HP:0200020)3.33449921
29Ridged nail (HP:0001807)3.23958755
30Hypohidrosis (HP:0000966)3.18040837
31Lip pit (HP:0100267)3.13932649
32Corneal dystrophy (HP:0001131)3.01965888
33Anonychia (HP:0001798)2.86496246
34Parakeratosis (HP:0001036)2.76248279
35Abnormality of the neuromuscular junction (HP:0003398)2.73937897
36Fatigable weakness (HP:0003473)2.73937897
37Atrophic scars (HP:0001075)2.71387616
38Abnormal hair laboratory examination (HP:0003328)2.66509570
39Hyperhidrosis (HP:0000975)2.58807725
40Type 1 muscle fiber predominance (HP:0003803)2.54165714
41Sparse eyelashes (HP:0000653)2.51343483
42Pruritus (HP:0000989)2.50466788
43Advanced eruption of teeth (HP:0006288)2.50360829
44Natal tooth (HP:0000695)2.48691585
45Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47321469
46Hypergammaglobulinemia (HP:0010702)2.41457159
47Verrucae (HP:0200043)2.39085819
48Papilloma (HP:0012740)2.39085819
49Muscle fiber inclusion bodies (HP:0100299)2.37843901
50Eczematoid dermatitis (HP:0000976)2.35837885
51Hyporeflexia of lower limbs (HP:0002600)2.35139067
52Ventricular tachycardia (HP:0004756)2.34199229
53Nemaline bodies (HP:0003798)2.33033121
54Increased connective tissue (HP:0009025)2.30473218
55Lack of skin elasticity (HP:0100679)2.17748652
56Curly hair (HP:0002212)2.16831272
57Muscle fiber splitting (HP:0003555)2.06717639
58Round ear (HP:0100830)2.01500585
59Distal arthrogryposis (HP:0005684)2.01416789
60Abnormality of nail color (HP:0100643)13.0610926
61Carious teeth (HP:0000670)1.94998356
62Myopathic facies (HP:0002058)1.88453388
63Abnormality of the fingernails (HP:0001231)1.86291995
64Distal lower limb muscle weakness (HP:0009053)1.82196243
65Skin ulcer (HP:0200042)1.80420786
66Blepharitis (HP:0000498)1.74352713
67Ulnar deviation of the wrist (HP:0003049)1.72511835
68Abnormality of the salivary glands (HP:0010286)1.70767037
69Acanthosis nigricans (HP:0000956)1.65852412
70Premature rupture of membranes (HP:0001788)1.63186340
71Achilles tendon contracture (HP:0001771)1.62254443
72Calcaneovalgus deformity (HP:0001848)1.60784295
73Hypoplastic ischia (HP:0003175)1.59752792
74Severe Myopia (HP:0011003)1.58445855
75Aplasia cutis congenita (HP:0001057)1.56790402
76Fragile skin (HP:0001030)1.53229724
77Neck muscle weakness (HP:0000467)1.52569152
78Neonatal onset (HP:0003623)1.51484565
79Sudden death (HP:0001699)1.49768874
80Autoamputation (HP:0001218)1.49715061
81Difficulty running (HP:0009046)1.49058538
82Hamartoma (HP:0010566)1.47044072
83Abnormality of the Achilles tendon (HP:0005109)1.47005362
84Vitreoretinal degeneration (HP:0000655)1.46854818
85Distal lower limb amyotrophy (HP:0008944)1.46284396
86Epiphyseal dysplasia (HP:0002656)1.45502828
87Melanocytic nevus (HP:0000995)1.41975702
88Dehydration (HP:0001944)1.39004506
89Deformed tarsal bones (HP:0008119)1.37761447
90Exercise-induced myalgia (HP:0003738)1.37628403
91Keratoconjunctivitis sicca (HP:0001097)1.36906952
92Absent phalangeal crease (HP:0006109)1.36314761
93Abnormality of the ischium (HP:0003174)1.35550516
94Neonatal short-limb short stature (HP:0008921)1.33494264
95Spinal rigidity (HP:0003306)1.33211126
96Paralysis (HP:0003470)1.32399549
97Ventricular fibrillation (HP:0001663)1.32347628
98Brittle hair (HP:0002299)1.31698369
99Abnormality of the calcaneus (HP:0008364)1.28226817
100Mildly elevated creatine phosphokinase (HP:0008180)1.27771599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.55429550
2FER4.12523952
3ERN13.60835146
4MAPKAPK33.50186051
5MST1R3.01971054
6TAOK12.93563686
7PIK3CG2.67141075
8EPHB12.64254895
9TTN2.52128235
10TRIB32.48643401
11NME12.29611367
12MAP3K112.24042582
13BLK2.17366476
14FGFR12.16082518
15EPHA32.10305027
16EPHA22.05963258
17MAP2K31.99951405
18MAP3K61.83942648
19MAP3K21.62721669
20DDR21.62659411
21MAP2K61.60265834
22FGFR41.59912502
23RPS6KA41.48159388
24TGFBR21.46583476
25EPHB21.43307563
26RPS6KB21.43066047
27MST41.42364125
28TRPM71.39677693
29MET1.35543310
30OBSCN1.28040425
31MAP3K11.23599332
32LATS11.21792336
33TESK11.18455117
34PIM21.18139179
35LIMK11.12362900
36FGFR31.09293297
37RIPK11.07332848
38STK241.07330282
39EEF2K1.05144712
40MAPKAPK51.05050170
41BCR1.01679594
42TYK21.00299733
43LRRK21.00010278
44MAP3K90.98043030
45MAPKAPK20.95509467
46MAP3K70.93138227
47STK100.84711207
48PTK20.83264672
49FGR0.80306630
50FGFR20.80195427
51MAP2K40.79591227
52NTRK20.77568342
53LATS20.75890753
54ERBB30.70667423
55DMPK0.68962165
56PKN20.67110077
57MAP3K50.65626511
58MAPK120.63596304
59PTK60.61107468
60CDK60.60766744
61PRKD10.58800909
62PDK30.56391341
63PDK40.56391341
64ILK0.56290412
65TIE10.56208128
66BMX0.55692450
67JAK10.55625904
68MAP2K10.54231628
69JAK30.54127281
70PDGFRA0.52932458
71PDK20.51762376
72PHKG10.51659287
73PHKG20.51659287
74ALK0.50134564
75TYRO30.49732160
76HCK0.49372827
77ROCK20.44611350
78GSK3A0.43405204
79MAPK40.41811901
80TAOK20.38466238
81PAK20.38199979
82RET0.38081344
83SIK10.36775853
84ITK0.33526088
85PKN10.32953048
86TBK10.32940759
87FYN0.32213466
88CSK0.30685752
89PRKCI0.29710618
90PAK30.29131383
91JAK20.28414004
92MAP4K10.27717153
93SRC0.27645292
94PDGFRB0.22537247
95RPS6KA10.21743545
96MAP3K80.21265053
97PIK3CA0.21242053
98MAP3K140.21196075
99ERBB40.20107888
100IKBKE0.19304512

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.27553495
2Linoleic acid metabolism_Homo sapiens_hsa005913.14107746
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.09100472
4Sphingolipid metabolism_Homo sapiens_hsa006002.46258135
5Arachidonic acid metabolism_Homo sapiens_hsa005902.46248360
6ECM-receptor interaction_Homo sapiens_hsa045122.44843145
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24816421
8Ether lipid metabolism_Homo sapiens_hsa005652.03522949
9Staphylococcus aureus infection_Homo sapiens_hsa051502.02885004
10VEGF signaling pathway_Homo sapiens_hsa043701.95989207
11Steroid biosynthesis_Homo sapiens_hsa001001.85707558
12GnRH signaling pathway_Homo sapiens_hsa049121.54151981
13Proteoglycans in cancer_Homo sapiens_hsa052051.53700112
14Phenylalanine metabolism_Homo sapiens_hsa003601.41774574
15Amoebiasis_Homo sapiens_hsa051461.39746121
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39148127
17Caffeine metabolism_Homo sapiens_hsa002321.39012494
18Histidine metabolism_Homo sapiens_hsa003401.35308754
19Pertussis_Homo sapiens_hsa051331.30650605
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29308685
21Fat digestion and absorption_Homo sapiens_hsa049751.27882065
22Sphingolipid signaling pathway_Homo sapiens_hsa040711.27297238
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27234095
24Adherens junction_Homo sapiens_hsa045201.24443208
25Toxoplasmosis_Homo sapiens_hsa051451.20850394
26Focal adhesion_Homo sapiens_hsa045101.20815294
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.19965918
28Tight junction_Homo sapiens_hsa045301.18788454
29Acute myeloid leukemia_Homo sapiens_hsa052211.18758305
30Platelet activation_Homo sapiens_hsa046111.16771837
31Protein digestion and absorption_Homo sapiens_hsa049741.13326394
32Long-term depression_Homo sapiens_hsa047301.11505584
33Axon guidance_Homo sapiens_hsa043601.09266089
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06508924
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02300869
36Bladder cancer_Homo sapiens_hsa052191.01764309
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.01544609
38Salmonella infection_Homo sapiens_hsa051320.97597341
39Renin secretion_Homo sapiens_hsa049240.96217405
40Malaria_Homo sapiens_hsa051440.94427281
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91861409
42Renal cell carcinoma_Homo sapiens_hsa052110.91630764
43Ras signaling pathway_Homo sapiens_hsa040140.90448838
44Pancreatic secretion_Homo sapiens_hsa049720.86527520
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86159165
46Dilated cardiomyopathy_Homo sapiens_hsa054140.83550171
47Dorso-ventral axis formation_Homo sapiens_hsa043200.83328361
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81010997
49Glioma_Homo sapiens_hsa052140.80700696
50Gastric acid secretion_Homo sapiens_hsa049710.80529120
51Melanogenesis_Homo sapiens_hsa049160.79911209
52Hippo signaling pathway_Homo sapiens_hsa043900.79401217
53Basal cell carcinoma_Homo sapiens_hsa052170.78524948
54MicroRNAs in cancer_Homo sapiens_hsa052060.77249865
55Rap1 signaling pathway_Homo sapiens_hsa040150.75803883
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74577521
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.72160500
58Oxytocin signaling pathway_Homo sapiens_hsa049210.70921937
59Endocytosis_Homo sapiens_hsa041440.69478322
60Osteoclast differentiation_Homo sapiens_hsa043800.68182582
61Hepatitis C_Homo sapiens_hsa051600.68121197
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67977359
63Insulin resistance_Homo sapiens_hsa049310.67799269
64PPAR signaling pathway_Homo sapiens_hsa033200.67434702
65Tuberculosis_Homo sapiens_hsa051520.67360720
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66901064
67Serotonergic synapse_Homo sapiens_hsa047260.66805506
68TNF signaling pathway_Homo sapiens_hsa046680.66128653
69Shigellosis_Homo sapiens_hsa051310.64104544
70ABC transporters_Homo sapiens_hsa020100.62984571
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.62873704
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62755268
73MAPK signaling pathway_Homo sapiens_hsa040100.62437731
74Leishmaniasis_Homo sapiens_hsa051400.61943917
75Salivary secretion_Homo sapiens_hsa049700.61730863
76Ovarian steroidogenesis_Homo sapiens_hsa049130.61510820
77Estrogen signaling pathway_Homo sapiens_hsa049150.60717429
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.58989171
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58487279
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56618848
81ErbB signaling pathway_Homo sapiens_hsa040120.55307753
82Tyrosine metabolism_Homo sapiens_hsa003500.54993594
83Long-term potentiation_Homo sapiens_hsa047200.54757222
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52872405
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52444446
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50836335
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47254655
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46818112
89Thyroid cancer_Homo sapiens_hsa052160.46471715
90Notch signaling pathway_Homo sapiens_hsa043300.45599353
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45244659
92Gap junction_Homo sapiens_hsa045400.45111364
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45060278
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44656823
95Retinol metabolism_Homo sapiens_hsa008300.43008983
96Pancreatic cancer_Homo sapiens_hsa052120.42533724
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.41997851
98Complement and coagulation cascades_Homo sapiens_hsa046100.40497776
99Choline metabolism in cancer_Homo sapiens_hsa052310.40476720
100Chemical carcinogenesis_Homo sapiens_hsa052040.39491108

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