KLKB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.61437257
2epoxygenase P450 pathway (GO:0019373)8.76994731
3ethanol oxidation (GO:0006069)7.07280946
4drug metabolic process (GO:0017144)6.37889567
5oxidative demethylation (GO:0070989)6.28778578
6glycine metabolic process (GO:0006544)6.03899402
7ethanol metabolic process (GO:0006067)5.78065243
8phenylpropanoid metabolic process (GO:0009698)5.53148748
9L-phenylalanine catabolic process (GO:0006559)5.52904723
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.52904723
11S-adenosylmethionine metabolic process (GO:0046500)5.16122053
12L-phenylalanine metabolic process (GO:0006558)5.03223415
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.03223415
14aromatic amino acid family catabolic process (GO:0009074)4.92972952
15serine family amino acid metabolic process (GO:0009069)4.87217901
16regulation of plasminogen activation (GO:0010755)4.78035424
17serine family amino acid biosynthetic process (GO:0009070)4.45471538
18alkaloid metabolic process (GO:0009820)4.38294490
19complement activation (GO:0006956)4.35960810
20tryptophan catabolic process (GO:0006569)4.32655641
21indole-containing compound catabolic process (GO:0042436)4.32655641
22indolalkylamine catabolic process (GO:0046218)4.32655641
23complement activation, classical pathway (GO:0006958)4.24510114
24presynaptic membrane assembly (GO:0097105)4.11738085
25bile acid biosynthetic process (GO:0006699)4.11139567
26regulation of humoral immune response (GO:0002920)4.08470891
27* negative regulation of coagulation (GO:0050819)4.06093087
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.06076445
29acute-phase response (GO:0006953)4.04824333
30tryptophan metabolic process (GO:0006568)4.04391154
31L-serine metabolic process (GO:0006563)4.03676752
32fat-soluble vitamin biosynthetic process (GO:0042362)3.99348825
33kynurenine metabolic process (GO:0070189)3.88528077
34hormone catabolic process (GO:0042447)3.85578167
35positive regulation of blood coagulation (GO:0030194)3.80059156
36positive regulation of hemostasis (GO:1900048)3.80059156
37cytolysis (GO:0019835)3.77649330
38xenobiotic metabolic process (GO:0006805)3.76946856
39positive regulation of lipoprotein lipase activity (GO:0051006)3.70057438
40positive regulation of triglyceride lipase activity (GO:0061365)3.70057438
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68941035
42flavonoid metabolic process (GO:0009812)3.68751680
43high-density lipoprotein particle remodeling (GO:0034375)3.68636065
44disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.67744816
45killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.67744816
46steroid catabolic process (GO:0006706)3.65068608
47postsynaptic membrane organization (GO:0001941)3.64455572
48peptidyl-glutamic acid carboxylation (GO:0017187)3.64081155
49protein carboxylation (GO:0018214)3.64081155
50primary alcohol catabolic process (GO:0034310)3.63195224
51response to mercury ion (GO:0046689)3.61848550
52intestinal cholesterol absorption (GO:0030299)3.56020854
53aromatic amino acid family metabolic process (GO:0009072)3.53807858
54* regulation of fibrinolysis (GO:0051917)3.53083964
55positive regulation of coagulation (GO:0050820)3.48956330
56L-methionine biosynthetic process (GO:0071265)3.47882713
57amino acid salvage (GO:0043102)3.47882713
58glyoxylate metabolic process (GO:0046487)3.47288208
59presynaptic membrane organization (GO:0097090)3.46513309
60bile acid metabolic process (GO:0008206)3.45084611
61negative regulation of lipase activity (GO:0060192)3.45077206
62negative regulation of fibrinolysis (GO:0051918)3.44418658
63cellular biogenic amine catabolic process (GO:0042402)3.44081792
64amine catabolic process (GO:0009310)3.44081792
65tyrosine metabolic process (GO:0006570)3.42051912
66regulation of protein activation cascade (GO:2000257)3.41962893
67complement activation, alternative pathway (GO:0006957)3.35397021
68cellular ketone body metabolic process (GO:0046950)3.34173002
69regulation of cholesterol esterification (GO:0010872)3.30957128
70positive regulation of cellular amine metabolic process (GO:0033240)3.27750914
71* blood coagulation, intrinsic pathway (GO:0007597)3.25887755
72protein-lipid complex remodeling (GO:0034368)3.23110482
73macromolecular complex remodeling (GO:0034367)3.23110482
74plasma lipoprotein particle remodeling (GO:0034369)3.23110482
75neuronal action potential propagation (GO:0019227)3.23105493
76reverse cholesterol transport (GO:0043691)3.20268738
77indolalkylamine metabolic process (GO:0006586)3.19626740
78serine family amino acid catabolic process (GO:0009071)3.16291785
79regulation of complement activation (GO:0030449)3.15549564
80acylglycerol homeostasis (GO:0055090)3.14818894
81triglyceride homeostasis (GO:0070328)3.14818894
82opsonization (GO:0008228)3.08475170
83positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.08402507
84urea metabolic process (GO:0019627)3.02518704
85urea cycle (GO:0000050)3.02518704
86heme transport (GO:0015886)3.02515856
87low-density lipoprotein particle remodeling (GO:0034374)3.01952610
88* fibrinolysis (GO:0042730)3.00914379
89glutamate metabolic process (GO:0006536)2.99832245
90imidazole-containing compound metabolic process (GO:0052803)2.98955890
91alpha-amino acid catabolic process (GO:1901606)2.98803678
92phospholipid efflux (GO:0033700)2.97473259
93keratinocyte development (GO:0003334)2.96117378
94bile acid and bile salt transport (GO:0015721)2.95843939
95cysteine metabolic process (GO:0006534)2.94658925
96coenzyme catabolic process (GO:0009109)2.94494368
97fatty acid elongation (GO:0030497)2.90726998
98ketone body metabolic process (GO:1902224)2.90163339
99aldehyde catabolic process (GO:0046185)2.87471586
100glucuronate metabolic process (GO:0019585)2.84629567
101uronic acid metabolic process (GO:0006063)2.84629567
102nitrogen cycle metabolic process (GO:0071941)2.83896392
103sulfur amino acid catabolic process (GO:0000098)2.79798143
104cholesterol efflux (GO:0033344)2.77582662
105arginine metabolic process (GO:0006525)2.76773452
106regulation of triglyceride catabolic process (GO:0010896)2.76046598
107cellular glucuronidation (GO:0052695)2.74595510
108neuron remodeling (GO:0016322)2.74235141
109very long-chain fatty acid metabolic process (GO:0000038)2.69214932
110cellular amino acid catabolic process (GO:0009063)2.68589560
111* protein activation cascade (GO:0072376)2.68173116
112limb bud formation (GO:0060174)2.67589544
113indole-containing compound metabolic process (GO:0042430)2.66620326
114benzene-containing compound metabolic process (GO:0042537)2.63022941
115* negative regulation of blood coagulation (GO:0030195)2.62985603
116* negative regulation of hemostasis (GO:1900047)2.62985603
117alpha-linolenic acid metabolic process (GO:0036109)2.60716989
118amino-acid betaine metabolic process (GO:0006577)2.60596880
119pyrimidine nucleobase catabolic process (GO:0006208)2.60364103
120omega-hydroxylase P450 pathway (GO:0097267)2.59955758
121cofactor catabolic process (GO:0051187)2.59167963
122short-chain fatty acid metabolic process (GO:0046459)2.58513419
123neuron cell-cell adhesion (GO:0007158)2.57873796
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57639335
125central nervous system myelination (GO:0022010)2.57216365
126axon ensheathment in central nervous system (GO:0032291)2.57216365
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.57028839
128drug catabolic process (GO:0042737)2.54922345
129regulation of bile acid biosynthetic process (GO:0070857)2.54309912
130short-term memory (GO:0007614)2.52615123
131cellular modified amino acid catabolic process (GO:0042219)2.52444319
132* negative regulation of wound healing (GO:0061045)2.51670405
133glutamate receptor signaling pathway (GO:0007215)2.51272929
134endothelium development (GO:0003158)2.50723483
135homocysteine metabolic process (GO:0050667)2.50579887
136negative regulation of protein activation cascade (GO:2000258)2.50122409
137negative regulation of sterol transport (GO:0032372)2.49346233
138negative regulation of cholesterol transport (GO:0032375)2.49346233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.73438489
2EZH2_22144423_ChIP-Seq_EOC_Human4.20164012
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.56307225
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45750040
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00250130
6GBX2_23144817_ChIP-Seq_PC3_Human2.87390339
7* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74440159
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59609106
9TAF15_26573619_Chip-Seq_HEK293_Human2.58511218
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.53992824
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47389176
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.34433616
13VDR_22108803_ChIP-Seq_LS180_Human2.33429084
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32573437
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32468163
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.26003339
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20214748
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15537000
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13030157
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10848003
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08607952
22HNF4A_19822575_ChIP-Seq_HepG2_Human2.07541939
23* LXR_22158963_ChIP-Seq_LIVER_Mouse2.04552193
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02551514
25CBX2_27304074_Chip-Seq_ESCs_Mouse2.00022628
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99141708
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99141708
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92657155
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89454662
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88303280
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87500157
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.85466884
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85350538
34AR_21572438_ChIP-Seq_LNCaP_Human1.79642920
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77689914
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76787573
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76778373
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75286471
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75153059
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.74332030
41P300_19829295_ChIP-Seq_ESCs_Human1.69408000
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66993899
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66246430
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.62918533
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62540906
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59546825
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57800101
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56780980
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51074188
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.48918652
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47000776
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.35954699
53TP53_18474530_ChIP-ChIP_U2OS_Human1.32138625
54BCAT_22108803_ChIP-Seq_LS180_Human1.31164480
55FUS_26573619_Chip-Seq_HEK293_Human1.31004695
56IRF1_19129219_ChIP-ChIP_H3396_Human1.30346476
57REST_21632747_ChIP-Seq_MESCs_Mouse1.29105397
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28457312
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.27439345
60IGF1R_20145208_ChIP-Seq_DFB_Human1.27306829
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.27195480
62SMAD4_21799915_ChIP-Seq_A2780_Human1.27066974
63RNF2_27304074_Chip-Seq_NSC_Mouse1.27066900
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26198515
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24668779
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24655441
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21447912
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19731893
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18680528
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17651497
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17362734
72PHF8_20622853_ChIP-Seq_HELA_Human1.15777270
73AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15291939
74* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15148007
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14769475
76CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14744408
77ER_23166858_ChIP-Seq_MCF-7_Human1.14323595
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.13571958
79P53_22387025_ChIP-Seq_ESCs_Mouse1.13494433
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13466809
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12600335
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12178797
83KDM2B_26808549_Chip-Seq_REH_Human1.11366938
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11035950
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.10839730
86HNFA_21074721_ChIP-Seq_CACO-2_Human1.10733699
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.09174299
88RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09119413
89HTT_18923047_ChIP-ChIP_STHdh_Human1.08844175
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06162158
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06085913
92P300_18555785_Chip-Seq_ESCs_Mouse1.04910405
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04382321
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04277300
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03967410
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.03657506
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03646721
98AR_25329375_ChIP-Seq_VCAP_Human1.03179425
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01501756
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99802970
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99344844
102RUNX2_22187159_ChIP-Seq_PCA_Human0.99161578
103STAT3_18555785_Chip-Seq_ESCs_Mouse0.98829026
104SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98553078
105WT1_19549856_ChIP-ChIP_CCG9911_Human0.98414041
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97002083
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97002083
108CRX_20693478_ChIP-Seq_RETINA_Mouse0.96324724
109NMYC_18555785_Chip-Seq_ESCs_Mouse0.96138115
110SOX2_18555785_Chip-Seq_ESCs_Mouse0.95519838
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95493907
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95371068
113CBP_21632823_ChIP-Seq_H3396_Human0.94661023
114TP53_16413492_ChIP-PET_HCT116_Human0.94430594
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94156562
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94050239
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93604255
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.93410296
119NFYA_21822215_ChIP-Seq_K562_Human0.93065126
120OCT4_18555785_Chip-Seq_ESCs_Mouse0.92104670
121PU1_27457419_Chip-Seq_LIVER_Mouse0.91515519
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90991400
123ETV1_20927104_ChIP-Seq_GIST48_Human0.89932949
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89844764
125GATA6_21074721_ChIP-Seq_CACO-2_Human0.89328048
126CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89276467
127* AR_20517297_ChIP-Seq_VCAP_Human0.88399701
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87472723
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86947739
130* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86618617
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86604583
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85448834
133RBPJ_21746931_ChIP-Seq_IB4_Human0.84315860
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.84007032
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83045908
136GATA4_25053715_ChIP-Seq_YYC3_Human0.81591236
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79102857
138SALL1_21062744_ChIP-ChIP_HESCs_Human0.78875834
139OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78769049
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78457241
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77949100
142CDX2_22108803_ChIP-Seq_LS180_Human0.77875727
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74661279
144SOX2_19829295_ChIP-Seq_ESCs_Human0.73531273
145NANOG_19829295_ChIP-Seq_ESCs_Human0.73531273
146* FOXA1_25552417_ChIP-Seq_VCAP_Human0.71428569
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.70939800
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70751124
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.70436191
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69436831
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.69324171
152GATA6_25053715_ChIP-Seq_YYC3_Human0.69179135
153CEBPB_22108803_ChIP-Seq_LS180_Human0.68295743
154NFYB_21822215_ChIP-Seq_K562_Human0.67910596
155KLF4_18555785_Chip-Seq_ESCs_Mouse0.67860066
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66266175
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66266175
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66266175
159* FOXA1_25329375_ChIP-Seq_VCAP_Human0.66263716
160* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66263716
161ESRRB_18555785_Chip-Seq_ESCs_Mouse0.65815768
162ZFX_18555785_Chip-Seq_ESCs_Mouse0.64285234
163TCF4_22108803_ChIP-Seq_LS180_Human0.64026536
164AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63662021
165* SOX2_21211035_ChIP-Seq_LN229_Human0.63533970
166ERG_20517297_ChIP-Seq_VCAP_Human0.62654707
167ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61859710
168P53_21459846_ChIP-Seq_SAOS-2_Human0.61554837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.91128681
2MP0005360_urolithiasis4.39799026
3MP0005085_abnormal_gallbladder_physiolo4.21291252
4MP0009379_abnormal_foot_pigmentation3.70688068
5MP0003136_yellow_coat_color3.59222984
6MP0008875_abnormal_xenobiotic_pharmacok3.53135794
7MP0005365_abnormal_bile_salt3.46624623
8MP0004381_abnormal_hair_follicle3.01138907
9MP0005409_darkened_coat_color2.81179639
10MP0003880_abnormal_central_pattern2.73259006
11MP0001188_hyperpigmentation2.49573259
12MP0003195_calcinosis2.14603000
13MP0002102_abnormal_ear_morphology2.09239561
14MP0003252_abnormal_bile_duct1.96641604
15MP0010329_abnormal_lipoprotein_level1.93798101
16MP0002876_abnormal_thyroid_physiology1.74425550
17MP0003868_abnormal_feces_composition1.67206132
18MP0003191_abnormal_cellular_cholesterol1.66489339
19MP0005332_abnormal_amino_acid1.62691848
20MP0006292_abnormal_olfactory_placode1.62592957
21MP0004019_abnormal_vitamin_homeostasis1.60733980
22MP0003011_delayed_dark_adaptation1.52710841
23MP0002837_dystrophic_cardiac_calcinosis1.48224047
24MP0001666_abnormal_nutrient_absorption1.47424256
25MP0005083_abnormal_biliary_tract1.44575230
26MP0009745_abnormal_behavioral_response1.44163953
27MP0006276_abnormal_autonomic_nervous1.42645722
28MP0000566_synostosis1.38451337
29MP0003635_abnormal_synaptic_transmissio1.37946638
30MP0001486_abnormal_startle_reflex1.37242307
31MP0001968_abnormal_touch/_nociception1.36030268
32MP0003186_abnormal_redox_activity1.32742587
33MP0002254_reproductive_system_inflammat1.27685645
34MP0000579_abnormal_nail_morphology1.26971565
35MP0002272_abnormal_nervous_system1.26943110
36MP0001501_abnormal_sleep_pattern1.26663207
37MP0005319_abnormal_enzyme/_coenzyme1.24090783
38MP0003806_abnormal_nucleotide_metabolis1.22307348
39MP0002118_abnormal_lipid_homeostasis1.20712273
40MP0002572_abnormal_emotion/affect_behav1.19561985
41MP0002249_abnormal_larynx_morphology1.18148844
42MP0002138_abnormal_hepatobiliary_system1.16469505
43MP0005646_abnormal_pituitary_gland1.16322035
44MP0005551_abnormal_eye_electrophysiolog1.15003382
45MP0005379_endocrine/exocrine_gland_phen1.14306784
46MP0002064_seizures1.12737659
47MP0001661_extended_life_span1.12143188
48MP0009780_abnormal_chondrocyte_physiolo1.11639911
49MP0004270_analgesia1.10011586
50MP0005451_abnormal_body_composition1.07911180
51MP0000598_abnormal_liver_morphology1.07321157
52MP0004859_abnormal_synaptic_plasticity1.06262430
53MP0003941_abnormal_skin_development1.03944898
54MP0004142_abnormal_muscle_tone1.02942554
55MP0001915_intracranial_hemorrhage1.02683261
56MP0003724_increased_susceptibility_to1.02424322
57MP0002063_abnormal_learning/memory/cond1.02301039
58MP0005595_abnormal_vascular_smooth1.01730509
59MP0002796_impaired_skin_barrier1.01003750
60MP0005584_abnormal_enzyme/coenzyme_acti1.00718090
61MP0003879_abnormal_hair_cell1.00354501
62MP0000026_abnormal_inner_ear0.98157839
63MP0005084_abnormal_gallbladder_morpholo0.97788975
64MP0003938_abnormal_ear_development0.97089733
65MP0001440_abnormal_grooming_behavior0.96805238
66MP0009046_muscle_twitch0.94310608
67MP0005535_abnormal_body_temperature0.93282287
68MP0005408_hypopigmentation0.93218684
69MP0009643_abnormal_urine_homeostasis0.92046200
70MP0000609_abnormal_liver_physiology0.91546569
71MP0002736_abnormal_nociception_after0.90618497
72MP0002132_abnormal_respiratory_system0.90459465
73MP0004043_abnormal_pH_regulation0.90042619
74MP0005395_other_phenotype0.89145563
75MP0004742_abnormal_vestibular_system0.87451567
76MP0002067_abnormal_sensory_capabilities0.84409051
77MP0009053_abnormal_anal_canal0.84043832
78MP0010386_abnormal_urinary_bladder0.83955082
79MP0002295_abnormal_pulmonary_circulatio0.83689491
80MP0001764_abnormal_homeostasis0.83561507
81MP0008872_abnormal_physiological_respon0.82374554
82MP0005636_abnormal_mineral_homeostasis0.82366111
83MP0009697_abnormal_copulation0.81471899
84MP0006036_abnormal_mitochondrial_physio0.81123795
85MP0009384_cardiac_valve_regurgitation0.80950099
86MP0009642_abnormal_blood_homeostasis0.80537603
87MP0005423_abnormal_somatic_nervous0.79420689
88MP0006072_abnormal_retinal_apoptosis0.79381276
89MP0002557_abnormal_social/conspecific_i0.79349681
90MP0002638_abnormal_pupillary_reflex0.78560839
91MP0005376_homeostasis/metabolism_phenot0.78547229
92MP0005670_abnormal_white_adipose0.78408069
93MP0009763_increased_sensitivity_to0.78193703
94MP0005647_abnormal_sex_gland0.77162867
95MP0003656_abnormal_erythrocyte_physiolo0.75866844
96MP0009840_abnormal_foam_cell0.75595022
97MP0009672_abnormal_birth_weight0.74953254
98MP0005248_abnormal_Harderian_gland0.74658542
99MP0002184_abnormal_innervation0.74647391
100MP0001963_abnormal_hearing_physiology0.74430969
101MP0002735_abnormal_chemical_nociception0.73377439
102MP0002098_abnormal_vibrissa_morphology0.73089654
103MP0002277_abnormal_respiratory_mucosa0.72408697
104MP0001664_abnormal_digestion0.72081177
105MP0005187_abnormal_penis_morphology0.72051841
106MP0001984_abnormal_olfaction0.71521431
107MP0001905_abnormal_dopamine_level0.71027043
108MP0000631_abnormal_neuroendocrine_gland0.70569918
109MP0003890_abnormal_embryonic-extraembry0.69956442
110MP0005645_abnormal_hypothalamus_physiol0.69241345
111MP0003718_maternal_effect0.69093582
112MP0001502_abnormal_circadian_rhythm0.68639517
113MP0008469_abnormal_protein_level0.67678832
114MP0003329_amyloid_beta_deposits0.67643256
115MP0010368_abnormal_lymphatic_system0.67604756
116MP0005174_abnormal_tail_pigmentation0.67138408
117MP0003690_abnormal_glial_cell0.66515051
118MP0000467_abnormal_esophagus_morphology0.66021790
119MP0002693_abnormal_pancreas_physiology0.65791046
120MP0000015_abnormal_ear_pigmentation0.65630231
121MP0000778_abnormal_nervous_system0.65270830
122MP0001944_abnormal_pancreas_morphology0.64811364
123MP0009764_decreased_sensitivity_to0.64492499
124MP0005266_abnormal_metabolism0.63594209
125MP0002078_abnormal_glucose_homeostasis0.63355398
126MP0002734_abnormal_mechanical_nocicepti0.60199315
127MP0002282_abnormal_trachea_morphology0.55084629
128MP0003638_abnormal_response/metabolism_0.54021061
129MP0006035_abnormal_mitochondrial_morpho0.52620548
130MP0002090_abnormal_vision0.52575018
131MP0002971_abnormal_brown_adipose0.51354579
132MP0002168_other_aberrant_phenotype0.51287098
133MP0000604_amyloidosis0.48937364
134MP0008874_decreased_physiological_sensi0.42550659
135MP0005334_abnormal_fat_pad0.40368106
136MP0004133_heterotaxia0.39512585
137MP0009765_abnormal_xenobiotic_induced0.38081075
138MP0005464_abnormal_platelet_physiology0.37967015
139MP0005220_abnormal_exocrine_pancreas0.37709557
140MP0002697_abnormal_eye_size0.31233497
141MP0003953_abnormal_hormone_level0.29690008
142MP0008873_increased_physiological_sensi0.29519127
143MP0005448_abnormal_energy_balance0.29044791
144MP0008877_abnormal_DNA_methylation0.28793405
145MP0003567_abnormal_fetal_cardiomyocyte0.28613573
146MP0001756_abnormal_urination0.27442990
147MP0001293_anophthalmia0.24423229
148MP0005023_abnormal_wound_healing0.23489361
149MP0001986_abnormal_taste_sensitivity0.23024824
150MP0002136_abnormal_kidney_physiology0.21182122
151MP0004782_abnormal_surfactant_physiolog0.20879912
152MP0009785_altered_susceptibility_to0.20111429
153MP0003699_abnormal_female_reproductive0.19018044
154MP0003878_abnormal_ear_physiology0.18670341
155MP0005377_hearing/vestibular/ear_phenot0.18670341
156MP0005166_decreased_susceptibility_to0.18543088
157MP0001730_embryonic_growth_arrest0.17028771
158MP0002332_abnormal_exercise_endurance0.16624611
159MP0009703_decreased_birth_body0.14429909
160MP0000249_abnormal_blood_vessel0.14318849
161MP0003119_abnormal_digestive_system0.12276482

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.75987959
2* Prolonged partial thromboplastin time (HP:0003645)5.44115556
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.23424567
4Intrahepatic cholestasis (HP:0001406)4.65466389
5Deep venous thrombosis (HP:0002625)4.43978498
6Joint hemorrhage (HP:0005261)4.39079558
7Recurrent gram-negative bacterial infections (HP:0005420)3.87049576
8Xanthomatosis (HP:0000991)3.85624984
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.84302287
10Conjugated hyperbilirubinemia (HP:0002908)3.77181824
11Hyperlipoproteinemia (HP:0010980)3.71583895
12Generalized aminoaciduria (HP:0002909)3.59912079
13Hypochromic microcytic anemia (HP:0004840)3.56963043
14Hypobetalipoproteinemia (HP:0003563)3.48662557
15Nephritis (HP:0000123)3.37838636
16Abnormality of the axillary hair (HP:0100134)3.35882587
17Abnormality of secondary sexual hair (HP:0009888)3.35882587
18Complement deficiency (HP:0004431)3.35704767
19Focal motor seizures (HP:0011153)3.35338423
20Hyperventilation (HP:0002883)3.24132205
21Hyperglycinemia (HP:0002154)3.20489828
22Osteomalacia (HP:0002749)3.07399423
23Abnormality of the common coagulation pathway (HP:0010990)3.03515029
24Abnormality of nucleobase metabolism (HP:0010932)2.86345165
25Hypophosphatemic rickets (HP:0004912)2.85102116
26Abnormality of methionine metabolism (HP:0010901)2.85033301
27Reduced antithrombin III activity (HP:0001976)2.81460692
28Neonatal hypoglycemia (HP:0001998)2.72235037
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71827137
30Epidermoid cyst (HP:0200040)2.68871446
31Cerebral edema (HP:0002181)2.68750346
32Vascular calcification (HP:0004934)2.68707784
33Parakeratosis (HP:0001036)2.66714194
34Abnormality of vitamin metabolism (HP:0100508)2.63328169
35Split foot (HP:0001839)2.62446180
36Hyperinsulinemic hypoglycemia (HP:0000825)2.62051259
37Ketosis (HP:0001946)2.60128080
38Hypolipoproteinemia (HP:0010981)2.59441422
39Renal Fanconi syndrome (HP:0001994)2.58523290
40Fat malabsorption (HP:0002630)2.57898606
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.48013599
42Gingival bleeding (HP:0000225)2.47834160
43Fair hair (HP:0002286)2.46830792
44Acute encephalopathy (HP:0006846)2.42547367
45Abnormality of glycine metabolism (HP:0010895)2.42242674
46Abnormality of serine family amino acid metabolism (HP:0010894)2.42242674
47Abnormal ciliary motility (HP:0012262)2.41112744
48Amyloidosis (HP:0011034)2.39833697
49Neurofibrillary tangles (HP:0002185)2.38338034
50Hypoalphalipoproteinemia (HP:0003233)2.35781430
51Acute necrotizing encephalopathy (HP:0006965)2.35256302
52Tubulointerstitial nephritis (HP:0001970)2.33715699
53Irritability (HP:0000737)2.33517440
54Spontaneous abortion (HP:0005268)2.31973278
55Cardiovascular calcification (HP:0011915)2.31101746
56Hypoglycemic coma (HP:0001325)2.30287320
57Abnormality of complement system (HP:0005339)2.29290717
58Thrombophlebitis (HP:0004418)2.27378347
59Hyperglycinuria (HP:0003108)2.26142232
60Increased hepatocellular lipid droplets (HP:0006565)2.25385632
61Menorrhagia (HP:0000132)2.25131563
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20835928
63Hepatocellular carcinoma (HP:0001402)2.19980972
64Lipid accumulation in hepatocytes (HP:0006561)2.19623721
65Confusion (HP:0001289)2.18215163
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.17713914
67Absent/shortened dynein arms (HP:0200106)2.17713914
68Enlarged kidneys (HP:0000105)2.16082030
69Status epilepticus (HP:0002133)2.14224177
70Delayed CNS myelination (HP:0002188)2.13299828
71Abnormality of the intrinsic pathway (HP:0010989)2.12926206
72Hypoglycemic seizures (HP:0002173)2.12781343
73Short tibia (HP:0005736)2.10223062
74Optic disc pallor (HP:0000543)2.09608912
75Lethargy (HP:0001254)2.09452169
76Pulmonary embolism (HP:0002204)2.08913902
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.07917658
78Mitral stenosis (HP:0001718)2.06804164
79Bifid scrotum (HP:0000048)2.05522487
80Cerebral inclusion bodies (HP:0100314)2.04464305
81Progressive macrocephaly (HP:0004481)2.04279826
82Hyperammonemia (HP:0001987)2.03546239
83Glomerulonephritis (HP:0000099)2.02441955
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.02035184
85Abnormal gallbladder physiology (HP:0012438)2.01893560
86Cholecystitis (HP:0001082)2.01893560
87Abnormality of serum amino acid levels (HP:0003112)2.01427341
88Abnormal gallbladder morphology (HP:0012437)2.00739884
89Methylmalonic acidemia (HP:0002912)2.00615854
90Abnormality of renal resorption (HP:0011038)1.99077813
91Hemorrhage of the eye (HP:0011885)1.97681180
92Hypercholesterolemia (HP:0003124)1.97488679
93Thyroid-stimulating hormone excess (HP:0002925)1.96693132
94Elevated alkaline phosphatase (HP:0003155)1.96044084
95Abnormal respiratory motile cilium physiology (HP:0012261)1.94681607
96Mitochondrial inheritance (HP:0001427)1.93638615
97Cholelithiasis (HP:0001081)1.92619147
98Glycosuria (HP:0003076)1.92366907
99Abnormality of urine glucose concentration (HP:0011016)1.92366907
100Rickets (HP:0002748)1.91546625
101Hyperbilirubinemia (HP:0002904)1.91433103
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90707732
103Symptomatic seizures (HP:0011145)1.90662871
104Purpura (HP:0000979)1.90278379
105Renal cortical cysts (HP:0000803)1.90105497
106Arthropathy (HP:0003040)1.88805725
107Generalized hypopigmentation of hair (HP:0011358)1.88655222
108Ketoacidosis (HP:0001993)1.87545607
109Bile duct proliferation (HP:0001408)1.86665483
110Abnormal biliary tract physiology (HP:0012439)1.86665483
111Hyperphosphaturia (HP:0003109)1.85840331
112Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85448951
113Humeroradial synostosis (HP:0003041)1.84895256
114Synostosis involving the elbow (HP:0003938)1.84895256
115Abnormal mitochondria in muscle tissue (HP:0008316)1.84056247
116Decreased central vision (HP:0007663)1.83226385
117Abnormality of purine metabolism (HP:0004352)1.83098196
118Aplasia cutis congenita (HP:0001057)1.82805305
119Increased serum pyruvate (HP:0003542)1.82721236
120Abnormal enzyme/coenzyme activity (HP:0012379)1.82177396
121Concave nail (HP:0001598)1.81101622
1223-Methylglutaconic aciduria (HP:0003535)1.80567252
123Sensorimotor neuropathy (HP:0007141)1.80505370
124Atonic seizures (HP:0010819)1.80281069
125Myocardial infarction (HP:0001658)1.80011148
126Abnormality of alkaline phosphatase activity (HP:0004379)1.79803111
127Abnormality of pyrimidine metabolism (HP:0004353)1.79197650
128Metabolic acidosis (HP:0001942)1.79123561
129Steatorrhea (HP:0002570)1.78355465
130Delayed myelination (HP:0012448)1.77494661
131Abnormal urine phosphate concentration (HP:0012599)1.77385651
132Generalized tonic-clonic seizures (HP:0002069)1.77165791
133Abnormal respiratory motile cilium morphology (HP:0005938)1.76930638
134Abnormal respiratory epithelium morphology (HP:0012253)1.76930638
135Poikilocytosis (HP:0004447)1.72913793
136Alkalosis (HP:0001948)1.65640020
137Megaloblastic anemia (HP:0001889)1.63616302
138Gout (HP:0001997)1.60449113
139Cerebral palsy (HP:0100021)1.60222406
140Abnormality of iron homeostasis (HP:0011031)1.59843943
141Abnormality of fatty-acid metabolism (HP:0004359)1.59322731
142Abnormality of the Achilles tendon (HP:0005109)1.57968454
143Increased serum ferritin (HP:0003281)1.57603844
144Increased mean platelet volume (HP:0011877)1.57088324
145Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.56386287
146Abnormality of glycolysis (HP:0004366)1.54994815
147Proximal tubulopathy (HP:0000114)1.54546537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59844871
2STK243.92621114
3BLK3.45792962
4INSRR3.44514981
5MKNK23.30644820
6WNK33.21514849
7TNIK3.13298999
8EPHA43.07073759
9TSSK63.01419340
10TTK2.92625674
11FGFR42.65590084
12FRK2.48970513
13NTRK32.32782532
14MUSK2.21155706
15RIPK42.13089354
16PLK32.05944221
17FES1.95508356
18MAPK151.94894584
19PRKD31.93892386
20ACVR1B1.89397141
21ZAK1.88826755
22CDC71.87769314
23BUB11.80667621
24TAF11.77919172
25STK161.77493514
26TAOK31.71986809
27GRK71.68768509
28EIF2AK11.68501513
29BMPR21.67137364
30SRPK11.59159998
31MAP2K71.59026505
32BRSK21.56336216
33EIF2AK31.55612499
34MST1R1.50574265
35RIPK11.50502874
36MAP2K41.47203448
37BCKDK1.41862289
38MKNK11.37319967
39TRIM281.34510686
40GRK11.34043722
41STK38L1.32032325
42NEK11.31721374
43FGR1.28774860
44GRK51.28272497
45SIK21.26876265
46NTRK21.24995978
47ALK1.21454657
48CAMK2B1.18937609
49TYK21.17893805
50NUAK11.17819574
51PKN11.16719794
52IGF1R1.15024672
53FER1.14713431
54DYRK1A1.14282237
55ERBB41.13882099
56CAMK2A1.12724844
57PLK41.08797033
58MAP3K41.07626585
59PLK11.05396488
60PNCK1.03790543
61CSNK1E1.02976637
62VRK21.02611859
63STK391.01465246
64ERN10.99103293
65FGFR30.99047765
66PRKCE0.98463132
67IRAK20.98442154
68MAP3K90.95710257
69MAP3K120.95442883
70PIK3CG0.94531826
71WNK40.93890594
72CDK30.93220034
73NME10.92244212
74PRKAA20.91725382
75MAPK130.90434840
76FGFR10.90064890
77PDK20.87979607
78OXSR10.87946664
79DAPK20.87398135
80PRKCQ0.86556290
81IRAK10.85907475
82CSNK1G10.84369869
83VRK10.83221677
84PRKCG0.83217436
85MAP3K130.81581648
86MAPK120.80232946
87ADRBK20.78507154
88NLK0.78056653
89PTK2B0.75602920
90CAMK2G0.74848922
91CAMK2D0.74316560
92CSNK2A10.73867800
93NTRK10.73804667
94BMPR1B0.73336115
95TLK10.72753187
96MST40.70601125
97CSNK2A20.67452032
98ERBB20.66283397
99MAP4K20.66250453
100PRKACA0.66032692
101FGFR20.65481548
102CSNK1D0.65172255
103EPHB20.64867228
104YES10.64784239
105EIF2AK20.62922435
106PRKACB0.61507624
107PRKG10.61396906
108CSNK1A10.61066308
109TIE10.60773722
110PLK20.59426621
111MAPK40.59300624
112GRK60.58666663
113PRKCB0.57953359
114ATM0.57681588
115IRAK30.57648241
116ADRBK10.57448400
117CDK50.57229717
118PINK10.56920719
119ABL20.56252354
120PRKDC0.56034727
121SIK10.55732480
122CDK60.54361168
123MYLK0.53924928
124STK110.51736608
125PBK0.50248447
126CSNK1G20.50200634
127PAK30.49772740
128ILK0.49209808
129PIK3CA0.48990612
130CAMK1D0.48837272
131MARK10.48424805
132CAMK10.48354695
133MAP3K140.47885268
134HIPK20.47371771
135BCR0.46672924
136PRKD20.46226527
137PRKCA0.45361152
138TNK20.44720652
139ARAF0.44355592
140DAPK10.43197123
141PRKCZ0.42986014
142PRKACG0.41577567
143RPS6KA30.40214292
144CAMK1G0.39789671
145MAP2K20.39567933
146KDR0.39361143
147NEK60.39289205
148GSK3A0.39000407
149DYRK20.38738064
150FYN0.37643972
151PRKAA10.37286044
152RAF10.36684020
153OBSCN0.36654656
154CSK0.36502779
155MARK20.35814537
156LYN0.35796120
157PAK40.35220809
158BRAF0.31342906
159SGK10.31075256

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.93338584
2* Complement and coagulation cascades_Homo sapiens_hsa046102.49290426
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41473452
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.35366292
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34587192
6Nitrogen metabolism_Homo sapiens_hsa009102.29104823
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28357959
8Tryptophan metabolism_Homo sapiens_hsa003802.19677232
9Arginine biosynthesis_Homo sapiens_hsa002202.16589011
10Histidine metabolism_Homo sapiens_hsa003402.15877841
11Butanoate metabolism_Homo sapiens_hsa006502.11243360
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02077159
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01204019
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.99708238
15Nicotine addiction_Homo sapiens_hsa050331.98190183
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96795192
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93154883
18Fatty acid elongation_Homo sapiens_hsa000621.90185493
19Chemical carcinogenesis_Homo sapiens_hsa052041.89645716
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88789950
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85011198
22Retinol metabolism_Homo sapiens_hsa008301.71971260
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71192672
24Sulfur metabolism_Homo sapiens_hsa009201.67759407
25Staphylococcus aureus infection_Homo sapiens_hsa051501.65314962
26Peroxisome_Homo sapiens_hsa041461.64917378
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61262867
28Vitamin B6 metabolism_Homo sapiens_hsa007501.57899586
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56324177
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.55327805
31beta-Alanine metabolism_Homo sapiens_hsa004101.49961351
32Fatty acid degradation_Homo sapiens_hsa000711.49774645
33Oxidative phosphorylation_Homo sapiens_hsa001901.48568878
34Protein export_Homo sapiens_hsa030601.40447624
35ABC transporters_Homo sapiens_hsa020101.38089235
36Bile secretion_Homo sapiens_hsa049761.37888552
37Tyrosine metabolism_Homo sapiens_hsa003501.37638215
38PPAR signaling pathway_Homo sapiens_hsa033201.32655683
39Taste transduction_Homo sapiens_hsa047421.28633943
40Phenylalanine metabolism_Homo sapiens_hsa003601.28525964
41Propanoate metabolism_Homo sapiens_hsa006401.24934533
42Biosynthesis of amino acids_Homo sapiens_hsa012301.20406846
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16855357
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10754089
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10208361
46Glutamatergic synapse_Homo sapiens_hsa047241.10138880
47Phototransduction_Homo sapiens_hsa047441.09391640
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07889652
49Steroid biosynthesis_Homo sapiens_hsa001001.06806833
50Alzheimers disease_Homo sapiens_hsa050101.06440483
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06324395
52GABAergic synapse_Homo sapiens_hsa047271.05657964
53One carbon pool by folate_Homo sapiens_hsa006701.04209614
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99544242
55Fatty acid metabolism_Homo sapiens_hsa012120.99477119
56Carbon metabolism_Homo sapiens_hsa012000.99370244
57Caffeine metabolism_Homo sapiens_hsa002320.97923393
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94401332
59Arginine and proline metabolism_Homo sapiens_hsa003300.91971705
60Serotonergic synapse_Homo sapiens_hsa047260.89812890
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.89443564
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86906550
63Starch and sucrose metabolism_Homo sapiens_hsa005000.85637730
64Vitamin digestion and absorption_Homo sapiens_hsa049770.84009145
65Folate biosynthesis_Homo sapiens_hsa007900.83872113
66Morphine addiction_Homo sapiens_hsa050320.74921767
67Fat digestion and absorption_Homo sapiens_hsa049750.73836192
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73463875
69Salivary secretion_Homo sapiens_hsa049700.72775659
70Linoleic acid metabolism_Homo sapiens_hsa005910.69787511
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.69407602
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69117629
73Parkinsons disease_Homo sapiens_hsa050120.68947879
74Amphetamine addiction_Homo sapiens_hsa050310.64721898
75Insulin secretion_Homo sapiens_hsa049110.64377160
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63146094
77Circadian entrainment_Homo sapiens_hsa047130.61675140
78Calcium signaling pathway_Homo sapiens_hsa040200.61198644
79Pyruvate metabolism_Homo sapiens_hsa006200.57893644
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57739030
81Renin secretion_Homo sapiens_hsa049240.56832067
82Long-term depression_Homo sapiens_hsa047300.56115847
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55572542
84Lysine degradation_Homo sapiens_hsa003100.55363910
85Metabolic pathways_Homo sapiens_hsa011000.53744892
86Selenocompound metabolism_Homo sapiens_hsa004500.52479127
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52028654
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51888548
89Ether lipid metabolism_Homo sapiens_hsa005650.51122833
90Arachidonic acid metabolism_Homo sapiens_hsa005900.46686659
91African trypanosomiasis_Homo sapiens_hsa051430.46008257
92Cardiac muscle contraction_Homo sapiens_hsa042600.45512722
93Cocaine addiction_Homo sapiens_hsa050300.44023393
94Sphingolipid metabolism_Homo sapiens_hsa006000.43388713
95Axon guidance_Homo sapiens_hsa043600.42507138
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41391654
97Ribosome_Homo sapiens_hsa030100.40488181
98Sulfur relay system_Homo sapiens_hsa041220.38758852
99Huntingtons disease_Homo sapiens_hsa050160.38360056
100Glutathione metabolism_Homo sapiens_hsa004800.38077575
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36799989
102Long-term potentiation_Homo sapiens_hsa047200.36793064
103Glycerolipid metabolism_Homo sapiens_hsa005610.34632249
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33644463
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32689773
106Dopaminergic synapse_Homo sapiens_hsa047280.32433552
107Ovarian steroidogenesis_Homo sapiens_hsa049130.31638703
108Prion diseases_Homo sapiens_hsa050200.31254813
109Fatty acid biosynthesis_Homo sapiens_hsa000610.29161024
110cAMP signaling pathway_Homo sapiens_hsa040240.27609963
111Fructose and mannose metabolism_Homo sapiens_hsa000510.23770206
112Pentose phosphate pathway_Homo sapiens_hsa000300.20822633
113Glucagon signaling pathway_Homo sapiens_hsa049220.16161285
114Pertussis_Homo sapiens_hsa051330.11244348
115Insulin resistance_Homo sapiens_hsa049310.10178330
116Galactose metabolism_Homo sapiens_hsa000520.02607415
117Proteasome_Homo sapiens_hsa030500.01849685
118Systemic lupus erythematosus_Homo sapiens_hsa053220.00735280
119N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2319945
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2291756
121Amoebiasis_Homo sapiens_hsa05146-0.2039120
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1756090
123Non-homologous end-joining_Homo sapiens_hsa03450-0.1676916
124Circadian rhythm_Homo sapiens_hsa04710-0.1675426
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.1664085
126Pyrimidine metabolism_Homo sapiens_hsa00240-0.1639960
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1538891
128Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.1274931
129Mismatch repair_Homo sapiens_hsa03430-0.1208261
130Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0995395
131AMPK signaling pathway_Homo sapiens_hsa04152-0.0985213
132Mineral absorption_Homo sapiens_hsa04978-0.0675830
133Renin-angiotensin system_Homo sapiens_hsa04614-0.0290796
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0179093

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