ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.62559437
2	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	5.37254258
3	primary amino compound metabolic process (GO:1901160)	5.26194897
4	serotonin metabolic process (GO:0042428)	4.90871234
5	detection of light stimulus involved in visual perception (GO:0050908)	4.73501076
6	detection of light stimulus involved in sensory perception (GO:0050962)	4.73501076
7	positive regulation of prostaglandin secretion (GO:0032308)	4.66486761
8	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.16740541
9	indolalkylamine metabolic process (GO:0006586)	4.09607834
10	neuronal action potential propagation (GO:0019227)	4.06164491
11	tryptophan catabolic process (GO:0006569)	3.96332890
12	indole-containing compound catabolic process (GO:0042436)	3.96332890
13	indolalkylamine catabolic process (GO:0046218)	3.96332890
14	indole-containing compound metabolic process (GO:0042430)	3.95703572
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.92288527
16	kynurenine metabolic process (GO:0070189)	3.88412436
17	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.83080521
18	retinal cone cell development (GO:0046549)	3.66500488
19	positive regulation of fatty acid transport (GO:2000193)	3.64881292
20	regulation of prostaglandin secretion (GO:0032306)	3.61739803
21	platelet dense granule organization (GO:0060155)	3.53857180
22	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.51671304
23	positive regulation of icosanoid secretion (GO:0032305)	3.50746119
24	nonmotile primary cilium assembly (GO:0035058)	3.48981600
25	reflex (GO:0060004)	3.47876868
26	photoreceptor cell maintenance (GO:0045494)	3.42067619
27	epithelial cilium movement (GO:0003351)	3.40012709
28	regulation of glucocorticoid secretion (GO:2000849)	3.37206209
29	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.32300243
30	negative regulation of telomere maintenance (GO:0032205)	3.26189705
31	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.26114784
32	gamma-aminobutyric acid transport (GO:0015812)	3.18040226
33	somite development (GO:0061053)	3.18035989
34	tryptophan metabolic process (GO:0006568)	3.10596613
35	protein K11-linked deubiquitination (GO:0035871)	3.09460114
36	neuronal action potential (GO:0019228)	3.05900831
37	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.01050035
38	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.01050035
39	regulation of translation, ncRNA-mediated (GO:0045974)	3.01050035
40	photoreceptor cell development (GO:0042461)	3.00068444
41	cytokine biosynthetic process (GO:0042089)	2.99488006
42	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.95190658
43	cellular ketone body metabolic process (GO:0046950)	2.94966400
44	regulation of telomere maintenance (GO:0032204)	2.93650499
45	cilium movement (GO:0003341)	2.93645908
46	cilium or flagellum-dependent cell motility (GO:0001539)	2.88074543
47	ubiquinone biosynthetic process (GO:0006744)	2.86984239
48	metallo-sulfur cluster assembly (GO:0031163)	2.80734253
49	iron-sulfur cluster assembly (GO:0016226)	2.80734253
50	eye photoreceptor cell development (GO:0042462)	2.79582882
51	behavioral response to ethanol (GO:0048149)	2.78945849
52	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.78564104
53	multicellular organism reproduction (GO:0032504)	2.76816997
54	ketone body metabolic process (GO:1902224)	2.76355837
55	intestinal epithelial cell development (GO:0060576)	2.74676685
56	cellular biogenic amine catabolic process (GO:0042402)	2.74073940
57	amine catabolic process (GO:0009310)	2.74073940
58	inner ear receptor stereocilium organization (GO:0060122)	2.73933186
59	synaptic transmission, cholinergic (GO:0007271)	2.72330980
60	sulfation (GO:0051923)	2.72047910
61	anterograde synaptic vesicle transport (GO:0048490)	2.71395810
62	regulation of hippo signaling (GO:0035330)	2.71245768
63	thyroid hormone metabolic process (GO:0042403)	2.71079098
64	DNA deamination (GO:0045006)	2.70473715
65	benzene-containing compound metabolic process (GO:0042537)	2.67516932
66	L-fucose catabolic process (GO:0042355)	2.65991409
67	fucose catabolic process (GO:0019317)	2.65991409
68	L-fucose metabolic process (GO:0042354)	2.65991409
69	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.62030437
70	organic cation transport (GO:0015695)	2.61289108
71	inositol phosphate catabolic process (GO:0071545)	2.59061843
72	ubiquinone metabolic process (GO:0006743)	2.58854106
73	cAMP catabolic process (GO:0006198)	2.57785395
74	regulation of corticosteroid hormone secretion (GO:2000846)	2.57018133
75	axoneme assembly (GO:0035082)	2.55994544
76	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.55191739
77	auditory receptor cell stereocilium organization (GO:0060088)	2.54283893
78	response to misfolded protein (GO:0051788)	2.54185139
79	positive regulation of organic acid transport (GO:0032892)	2.50235928
80	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.49569732
81	regulation of appetite (GO:0032098)	2.49082407
82	piRNA metabolic process (GO:0034587)	2.48626541
83	S-adenosylmethionine metabolic process (GO:0046500)	2.47885417
84	cytokine metabolic process (GO:0042107)	2.46862093
85	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.45953414
86	detection of chemical stimulus involved in sensory perception (GO:0050907)	2.45806613
87	C4-dicarboxylate transport (GO:0015740)	2.45738483
88	response to pheromone (GO:0019236)	2.45531169
89	regulation of cardioblast proliferation (GO:0003264)	2.44801093
90	regulation of secondary heart field cardioblast proliferation (GO:0003266)	2.44801093
91	thyroid hormone generation (GO:0006590)	2.44119159
92	regulation of cilium movement (GO:0003352)	2.44104055
93	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42765012
94	inositol phosphate dephosphorylation (GO:0046855)	2.42765012
95	cilium organization (GO:0044782)	2.42176511
96	positive regulation of defense response to virus by host (GO:0002230)	2.41152964
97	regulation of MHC class I biosynthetic process (GO:0045343)	2.40922541
98	cyclic nucleotide catabolic process (GO:0009214)	2.40548108
99	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.40489691
100	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.38596457

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.26693684
2	VDR_22108803_ChIP-Seq_LS180_Human	3.15043862
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.93886453
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.83701410
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.80725711
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.75471715
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37125146
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32090543
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.29583080
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.23395237
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19272492
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.12247298
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.10150475
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.05398187
15	P300_19829295_ChIP-Seq_ESCs_Human	2.03127941
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.01105819
17	FUS_26573619_Chip-Seq_HEK293_Human	1.95615010
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94837884
19	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87461085
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.86019089
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83988695
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.83789454
23	EWS_26573619_Chip-Seq_HEK293_Human	1.81972004
24	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81782816
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.79953608
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.77028262
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74633211
28	AR_25329375_ChIP-Seq_VCAP_Human	1.67807284
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66259470
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66047574
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65945973
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.65945973
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64418579
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64288596
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.62550398
36	STAT3_23295773_ChIP-Seq_U87_Human	1.60375625
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59366475
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59366475
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56063600
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.55566402
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53887007
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46357914
43	TCF4_23295773_ChIP-Seq_U87_Human	1.46312967
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45094411
45	TCF4_22108803_ChIP-Seq_LS180_Human	1.44867737
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42695691
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41368245
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41046273
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.40471419
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40143825
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40000080
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39285291
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36717885
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34103433
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31056459
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30980221
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30980221
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30278970
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30247791
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27283146
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26602729
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24340269
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22838845
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22838845
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.21780793
66	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21466569
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21346127
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21112358
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20329128
70	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.19845366
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19217308
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19121226
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18568234
74	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.18556189
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17429561
76	RXR_22108803_ChIP-Seq_LS180_Human	1.17058609
77	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.16928705
78	NCOR_22424771_ChIP-Seq_293T_Human	1.16873693
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.16807334
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16312939
81	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15827787
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.14490372
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13845671
84	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13750994
85	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.13388373
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.09830116
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09641887
88	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09575536
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08428171
90	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06030378
91	ETV1_20927104_ChIP-Seq_GIST48_Human	1.04461583
92	DROSHA_22980978_ChIP-Seq_HELA_Human	1.04244239
93	* AR_20517297_ChIP-Seq_VCAP_Human	1.02181708
94	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.01574419
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.00647717
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00537361
97	MYC_18940864_ChIP-ChIP_HL60_Human	0.99662654
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99243194
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99029398
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.98823387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.21430005
2	MP0000569_abnormal_digit_pigmentation	3.99432454
3	MP0001968_abnormal_touch/_nociception	3.79588681
4	MP0003283_abnormal_digestive_organ	3.49175116
5	MP0005503_abnormal_tendon_morphology	2.73242028
6	MP0002736_abnormal_nociception_after	2.62996321
7	MP0005551_abnormal_eye_electrophysiolog	2.52301368
8	MP0008877_abnormal_DNA_methylation	2.48532565
9	MP0002254_reproductive_system_inflammat	2.47769162
10	MP0001501_abnormal_sleep_pattern	2.39522943
11	MP0003880_abnormal_central_pattern	2.29034931
12	MP0003646_muscle_fatigue	2.16975882
13	MP0006276_abnormal_autonomic_nervous	2.06702121
14	MP0003195_calcinosis	1.99021275
15	MP0009745_abnormal_behavioral_response	1.97946187
16	MP0005253_abnormal_eye_physiology	1.92846013
17	MP0009046_muscle_twitch	1.89564490
18	MP0010386_abnormal_urinary_bladder	1.89329828
19	MP0002638_abnormal_pupillary_reflex	1.84692044
20	MP0002909_abnormal_adrenal_gland	1.78823811
21	MP0005174_abnormal_tail_pigmentation	1.76846963
22	MP0006054_spinal_hemorrhage	1.73620951
23	MP0003950_abnormal_plasma_membrane	1.67601104
24	MP0002938_white_spotting	1.61966887
25	MP0005645_abnormal_hypothalamus_physiol	1.61194315
26	MP0003787_abnormal_imprinting	1.59883440
27	MP0000372_irregular_coat_pigmentation	1.59005176
28	MP0000427_abnormal_hair_cycle	1.58337977
29	MP0002272_abnormal_nervous_system	1.54472016
30	MP0002138_abnormal_hepatobiliary_system	1.46066884
31	MP0004142_abnormal_muscle_tone	1.45078721
32	MP0001486_abnormal_startle_reflex	1.42520347
33	MP0001905_abnormal_dopamine_level	1.41340715
34	MP0005083_abnormal_biliary_tract	1.37280508
35	MP0004924_abnormal_behavior	1.36629183
36	MP0005386_behavior/neurological_phenoty	1.36629183
37	MP0006072_abnormal_retinal_apoptosis	1.34341286
38	MP0005647_abnormal_sex_gland	1.33729461
39	MP0002876_abnormal_thyroid_physiology	1.32827901
40	MP0005646_abnormal_pituitary_gland	1.32395727
41	MP0002067_abnormal_sensory_capabilities	1.29468049
42	MP0000613_abnormal_salivary_gland	1.27291497
43	MP0004147_increased_porphyrin_level	1.25218250
44	MP0000538_abnormal_urinary_bladder	1.24913594
45	MP0002837_dystrophic_cardiac_calcinosis	1.23640563
46	MP0002557_abnormal_social/conspecific_i	1.22634392
47	MP0004134_abnormal_chest_morphology	1.22108442
48	MP0002282_abnormal_trachea_morphology	1.18981485
49	MP0005671_abnormal_response_to	1.17659514
50	MP0008875_abnormal_xenobiotic_pharmacok	1.17253408
51	MP0004742_abnormal_vestibular_system	1.15918945
52	MP0000631_abnormal_neuroendocrine_gland	1.13788037
53	MP0002064_seizures	1.10597111
54	MP0002572_abnormal_emotion/affect_behav	1.08230543
55	MP0005171_absent_coat_pigmentation	1.07403961
56	MP0008872_abnormal_physiological_respon	1.07307610
57	MP0001970_abnormal_pain_threshold	1.05295508
58	MP0000015_abnormal_ear_pigmentation	1.03384284
59	MP0000371_diluted_coat_color	1.03226010
60	MP0002735_abnormal_chemical_nociception	1.00564163
61	MP0002733_abnormal_thermal_nociception	0.99637527
62	MP0002108_abnormal_muscle_morphology	0.98593887
63	MP0002095_abnormal_skin_pigmentation	0.96419305
64	MP0001963_abnormal_hearing_physiology	0.95671586
65	MP0003698_abnormal_male_reproductive	0.94416541
66	MP0000639_abnormal_adrenal_gland	0.93959045
67	MP0005410_abnormal_fertilization	0.92807823
68	MP0008995_early_reproductive_senescence	0.91104605
69	MP0000516_abnormal_urinary_system	0.90085688
70	MP0005367_renal/urinary_system_phenotyp	0.90085688
71	MP0001986_abnormal_taste_sensitivity	0.89645917
72	MP0000026_abnormal_inner_ear	0.88180859
73	MP0004885_abnormal_endolymph	0.87726992
74	MP0003937_abnormal_limbs/digits/tail_de	0.87126966
75	MP0005389_reproductive_system_phenotype	0.85793840
76	MP0001984_abnormal_olfaction	0.85112265
77	MP0004043_abnormal_pH_regulation	0.84441211
78	MP0005508_abnormal_skeleton_morphology	0.84374395
79	MP0000383_abnormal_hair_follicle	0.83629009
80	MP0010329_abnormal_lipoprotein_level	0.82619627
81	MP0003252_abnormal_bile_duct	0.82408408
82	MP0002160_abnormal_reproductive_system	0.82140500
83	MP0002751_abnormal_autonomic_nervous	0.81527573
84	MP0002734_abnormal_mechanical_nocicepti	0.80053664
85	MP0000230_abnormal_systemic_arterial	0.78302635
86	MP0005075_abnormal_melanosome_morpholog	0.77910754
87	MP0003635_abnormal_synaptic_transmissio	0.77729387
88	MP0003718_maternal_effect	0.77246828
89	MP0002234_abnormal_pharynx_morphology	0.76300362
90	MP0002752_abnormal_somatic_nervous	0.75823613
91	MP0002229_neurodegeneration	0.74778366
92	MP0004883_abnormal_blood_vessel	0.74769312
93	MP0003137_abnormal_impulse_conducting	0.72862208
94	MP0005195_abnormal_posterior_eye	0.72835894
95	MP0009250_abnormal_appendicular_skeleto	0.71859832
96	MP0002063_abnormal_learning/memory/cond	0.71607409
97	MP0003136_yellow_coat_color	0.70215400
98	MP0001324_abnormal_eye_pigmentation	0.69002585
99	MP0005167_abnormal_blood-brain_barrier	0.68708224
100	MP0004133_heterotaxia	0.67818818

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.55363298
2	Abnormality of midbrain morphology (HP:0002418)	4.25694761
3	Molar tooth sign on MRI (HP:0002419)	4.25694761
4	Pancreatic fibrosis (HP:0100732)	4.03932276
5	Congenital stationary night blindness (HP:0007642)	3.93511032
6	True hermaphroditism (HP:0010459)	3.54368560
7	Abnormal drinking behavior (HP:0030082)	3.48248341
8	Polydipsia (HP:0001959)	3.48248341
9	Abnormality of the renal cortex (HP:0011035)	3.48183904
10	Tubular atrophy (HP:0000092)	3.44440308
11	Hyperventilation (HP:0002883)	3.41801871
12	Nephronophthisis (HP:0000090)	3.36230988
13	Fair hair (HP:0002286)	3.18206190
14	Abnormality of the renal medulla (HP:0100957)	3.08445299
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.07132630
16	Gaze-evoked nystagmus (HP:0000640)	3.00189770
17	Attenuation of retinal blood vessels (HP:0007843)	2.99423538
18	Polyuria (HP:0000103)	2.87031033
19	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.84050448
20	Decreased central vision (HP:0007663)	2.78595229
21	Medial flaring of the eyebrow (HP:0010747)	2.75972001
22	Congenital, generalized hypertrichosis (HP:0004540)	2.73301687
23	Abnormality of secondary sexual hair (HP:0009888)	2.73024509
24	Abnormality of the axillary hair (HP:0100134)	2.73024509
25	Keratoconus (HP:0000563)	2.70852217
26	Increased corneal curvature (HP:0100692)	2.70852217
27	Generalized hypopigmentation of hair (HP:0011358)	2.69004003
28	Abnormal biliary tract physiology (HP:0012439)	2.65858419
29	Bile duct proliferation (HP:0001408)	2.65858419
30	Febrile seizures (HP:0002373)	2.63826986
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.62685074
32	Hypoglycemic seizures (HP:0002173)	2.57780423
33	Stomach cancer (HP:0012126)	2.47787091
34	Cystic liver disease (HP:0006706)	2.47387823
35	Renal cortical cysts (HP:0000803)	2.45699218
36	Focal motor seizures (HP:0011153)	2.44834754
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.43677505
38	Small hand (HP:0200055)	2.43653766
39	Focal seizures (HP:0007359)	2.43309103
40	Inability to walk (HP:0002540)	2.39986237
41	Absent frontal sinuses (HP:0002688)	2.33210242
42	Type II lissencephaly (HP:0007260)	2.32476576
43	Hemiparesis (HP:0001269)	2.30772063
44	Progressive inability to walk (HP:0002505)	2.30431346
45	Abnormal urine output (HP:0012590)	2.27393594
46	Protruding tongue (HP:0010808)	2.26702733
47	Tubulointerstitial fibrosis (HP:0005576)	2.26238881
48	Aplasia of the musculature (HP:0100854)	2.24727346
49	Bifid tongue (HP:0010297)	2.24357155
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20002091
51	Intestinal atresia (HP:0011100)	2.17290648
52	Congenital hepatic fibrosis (HP:0002612)	2.15671571
53	Decreased circulating renin level (HP:0003351)	2.14674060
54	Bony spicule pigmentary retinopathy (HP:0007737)	2.12493217
55	Gait imbalance (HP:0002141)	2.09359576
56	Tubulointerstitial abnormality (HP:0001969)	2.06426733
57	Asplenia (HP:0001746)	2.06109221
58	Short tibia (HP:0005736)	2.05074212
59	Ulnar claw (HP:0001178)	2.03699720
60	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03564768
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03381468
62	Congenital primary aphakia (HP:0007707)	1.99776704
63	Dialeptic seizures (HP:0011146)	1.97909199
64	Atonic seizures (HP:0010819)	1.96312548
65	Hypoplastic ischia (HP:0003175)	1.95522911
66	Abnormality of renal excretion (HP:0011036)	1.94153866
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.92956230
68	Abnormal protein glycosylation (HP:0012346)	1.92956230
69	Abnormal glycosylation (HP:0012345)	1.92956230
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92956230
71	Hypothermia (HP:0002045)	1.92687918
72	Absent speech (HP:0001344)	1.92002141
73	Metaphyseal dysplasia (HP:0100255)	1.89731677
74	Dry hair (HP:0011359)	1.89153150
75	Sclerocornea (HP:0000647)	1.88672614
76	Anencephaly (HP:0002323)	1.87835040
77	Disproportionate short-trunk short stature (HP:0003521)	1.85775930
78	Oculomotor apraxia (HP:0000657)	1.84146187
79	Male pseudohermaphroditism (HP:0000037)	1.83087893
80	Pendular nystagmus (HP:0012043)	1.82667302
81	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.81387865
82	Postaxial foot polydactyly (HP:0001830)	1.81257449
83	Absent thumb (HP:0009777)	1.80602745
84	Elevated erythrocyte sedimentation rate (HP:0003565)	1.78232730
85	Abolished electroretinogram (ERG) (HP:0000550)	1.77724457
86	Chronic hepatic failure (HP:0100626)	1.73079689
87	Type I transferrin isoform profile (HP:0003642)	1.72521803
88	Enlarged kidneys (HP:0000105)	1.71749265
89	Genital tract atresia (HP:0001827)	1.71562678
90	Progressive cerebellar ataxia (HP:0002073)	1.71213162
91	Narrow forehead (HP:0000341)	1.70699849
92	Postaxial hand polydactyly (HP:0001162)	1.70485331
93	Severe muscular hypotonia (HP:0006829)	1.68975373
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.68520883
95	Absent/shortened dynein arms (HP:0200106)	1.68520883
96	Generalized myoclonic seizures (HP:0002123)	1.68007971
97	Nephrogenic diabetes insipidus (HP:0009806)	1.67169463
98	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.66602618
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.65938222
100	Vaginal atresia (HP:0000148)	1.65885510

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.33695304
2	ADRBK2	3.52470129
3	TLK1	2.87081514
4	GRK1	2.66817166
5	CASK	2.64465518
6	BMPR1B	2.55029513
7	WNK3	2.41206378
8	MAPK13	2.40473429
9	NUAK1	2.13966353
10	MAP3K4	2.08797225
11	TNIK	1.95729862
12	PINK1	1.87072562
13	PDK2	1.84744953
14	MST4	1.83943758
15	FGFR2	1.75355388
16	NTRK3	1.63809182
17	ACVR1B	1.61735849
18	MAP4K2	1.46808452
19	MKNK2	1.42587338
20	PAK3	1.40993252
21	AKT3	1.40081005
22	ZAK	1.39656057
23	TAOK3	1.39626799
24	TEC	1.28694718
25	STK39	1.27675332
26	PTK2B	1.27078175
27	TXK	1.25355464
28	PLK2	1.23437806
29	ADRBK1	1.23192243
30	CLK1	1.21333732
31	TNK2	1.14866260
32	MAP2K7	1.14312898
33	WNK4	1.12159036
34	OXSR1	1.11176645
35	ERBB2	1.07768889
36	IRAK1	1.05576101
37	INSRR	1.01148303
38	DYRK1A	1.00441727
39	EPHA4	0.98612488
40	MARK3	0.96876777
41	PRKCE	0.94922390
42	VRK1	0.90642707
43	PRKCG	0.87080299
44	MARK1	0.81123319
45	STK38L	0.79971452
46	MAPKAPK3	0.75316623
47	PKN1	0.71418925
48	CAMKK2	0.68378975
49	PRKD2	0.67393503
50	CSNK1G1	0.67082813
51	PHKG2	0.66932081
52	PHKG1	0.66932081
53	TRIM28	0.65823795
54	CAMK2A	0.63897795
55	DAPK2	0.62823066
56	PNCK	0.62369227
57	JAK1	0.60893085
58	FGFR3	0.60870308
59	NTRK2	0.60781188
60	PRKCI	0.59544320
61	ERBB3	0.59170785
62	NLK	0.57376574
63	FER	0.55631943
64	ITK	0.53299440
65	NME1	0.51435765
66	PIK3CA	0.50510101
67	PRKACA	0.49625454
68	TYK2	0.49302199
69	PAK6	0.48207476
70	CAMK1D	0.47787082
71	CAMK1G	0.47176997
72	CSNK1G2	0.45841296
73	CSNK1A1	0.45596854
74	IKBKB	0.44722247
75	RPS6KA5	0.43863669
76	STK3	0.43063325
77	BRSK2	0.42895978
78	CSNK1D	0.42496202
79	ABL2	0.42348755
80	PRKCQ	0.42324708
81	BMPR2	0.41503143
82	BCR	0.41235032
83	SGK2	0.39767178
84	CSNK1A1L	0.39018327
85	ABL1	0.35898431
86	OBSCN	0.35228009
87	PRKCH	0.33904781
88	PRKCA	0.33659483
89	PRKAA1	0.33219253
90	SRPK1	0.33086353
91	CAMK1	0.32261413
92	PRKAA2	0.32206903
93	IKBKE	0.30528591
94	KIT	0.30512769
95	MAP2K6	0.30466109
96	EGFR	0.30044952
97	STK11	0.29243362
98	CSNK1G3	0.29098156
99	TGFBR1	0.28744439
100	PRKG1	0.27351309

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.75803891
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.67166085
3	Phototransduction_Homo sapiens_hsa04744	3.15458196
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.04547060
5	Butanoate metabolism_Homo sapiens_hsa00650	2.81268898
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.57561536
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52066680
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.28565941
9	Olfactory transduction_Homo sapiens_hsa04740	2.09406286
10	Nicotine addiction_Homo sapiens_hsa05033	2.02871444
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93682846
12	Taste transduction_Homo sapiens_hsa04742	1.89882683
13	Propanoate metabolism_Homo sapiens_hsa00640	1.88200880
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.80778152
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.66385506
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56334313
17	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.49585317
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48495789
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48487210
20	Homologous recombination_Homo sapiens_hsa03440	1.42565162
21	Caffeine metabolism_Homo sapiens_hsa00232	1.42515237
22	Protein export_Homo sapiens_hsa03060	1.40552621
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39136467
24	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36019584
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34469505
26	Asthma_Homo sapiens_hsa05310	1.25851313
27	Basal transcription factors_Homo sapiens_hsa03022	1.25280143
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23868124
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.22884775
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22101691
31	Peroxisome_Homo sapiens_hsa04146	1.20530614
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.19533694
33	Morphine addiction_Homo sapiens_hsa05032	1.16363860
34	ABC transporters_Homo sapiens_hsa02010	1.14945164
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01125143
36	Circadian rhythm_Homo sapiens_hsa04710	1.00113222
37	Allograft rejection_Homo sapiens_hsa05330	0.99689820
38	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.97799784
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96886416
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96158077
41	African trypanosomiasis_Homo sapiens_hsa05143	0.88983037
42	Regulation of autophagy_Homo sapiens_hsa04140	0.87236330
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.87199900
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.85876776
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.83666001
46	Retinol metabolism_Homo sapiens_hsa00830	0.83511858
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.81042824
48	Mineral absorption_Homo sapiens_hsa04978	0.80010666
49	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79842556
50	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.79385990
51	Serotonergic synapse_Homo sapiens_hsa04726	0.79364541
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.76337791
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.75102957
54	Insulin secretion_Homo sapiens_hsa04911	0.73577009
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73258016
56	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72824869
57	Circadian entrainment_Homo sapiens_hsa04713	0.72065937
58	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71679321
59	Salivary secretion_Homo sapiens_hsa04970	0.71225915
60	Sulfur relay system_Homo sapiens_hsa04122	0.70103789
61	RNA polymerase_Homo sapiens_hsa03020	0.69967681
62	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69355440
63	Parkinsons disease_Homo sapiens_hsa05012	0.68915489
64	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.67849101
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.67759805
66	One carbon pool by folate_Homo sapiens_hsa00670	0.67572851
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67453963
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66986560
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66658974
70	RNA degradation_Homo sapiens_hsa03018	0.64942640
71	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64917697
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63219135
73	Graft-versus-host disease_Homo sapiens_hsa05332	0.63189795
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.62509103
75	Proteasome_Homo sapiens_hsa03050	0.61871465
76	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.61710211
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60425937
78	Cardiac muscle contraction_Homo sapiens_hsa04260	0.58970199
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56947350
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.56083108
81	Dopaminergic synapse_Homo sapiens_hsa04728	0.52425782
82	Glutathione metabolism_Homo sapiens_hsa00480	0.50896992
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48984555
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46628380
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46320184
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.44523880
87	Metabolic pathways_Homo sapiens_hsa01100	0.43033292
88	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.42570155
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40472395
90	Alzheimers disease_Homo sapiens_hsa05010	0.39229671
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39177705
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.39153261
93	GABAergic synapse_Homo sapiens_hsa04727	0.36798535
94	Cocaine addiction_Homo sapiens_hsa05030	0.36617502
95	Pancreatic secretion_Homo sapiens_hsa04972	0.36511514
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36402423
97	Huntingtons disease_Homo sapiens_hsa05016	0.34796516
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34719204
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.34623048
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34570929

KLKP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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