ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axon ensheathment in central nervous system (GO:0032291)	5.63973685
2	central nervous system myelination (GO:0022010)	5.63973685
3	DNA double-strand break processing (GO:0000729)	5.14278207
4	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.94700531
5	chromatin remodeling at centromere (GO:0031055)	4.68276241
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.37012229
7	CENP-A containing nucleosome assembly (GO:0034080)	4.34477799
8	neural tube formation (GO:0001841)	4.27279517
9	negative regulation of astrocyte differentiation (GO:0048712)	4.24756438
10	negative regulation of DNA recombination (GO:0045910)	4.13459220
11	regulation of cilium movement (GO:0003352)	4.13047763
12	replication fork processing (GO:0031297)	4.09001174
13	response to pheromone (GO:0019236)	4.08040124
14	protein neddylation (GO:0045116)	4.07627854
15	histone exchange (GO:0043486)	3.98456916
16	forebrain neuron differentiation (GO:0021879)	3.95188305
17	intraciliary transport (GO:0042073)	3.81951162
18	centriole replication (GO:0007099)	3.76422317
19	neuronal action potential propagation (GO:0019227)	3.68253941
20	histone H2B ubiquitination (GO:0033523)	3.66773236
21	epithelial cilium movement (GO:0003351)	3.46720819
22	DNA replication-independent nucleosome organization (GO:0034724)	3.43414482
23	DNA replication-independent nucleosome assembly (GO:0006336)	3.43414482
24	translesion synthesis (GO:0019985)	3.41870720
25	intra-S DNA damage checkpoint (GO:0031573)	3.41697608
26	microtubule depolymerization (GO:0007019)	3.39834186
27	tongue development (GO:0043586)	3.38624350
28	lateral sprouting from an epithelium (GO:0060601)	3.31781366
29	acrosome assembly (GO:0001675)	3.25332002
30	regulation of centriole replication (GO:0046599)	3.23102002
31	kinetochore organization (GO:0051383)	3.16927834
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.13281132
33	mitotic G2/M transition checkpoint (GO:0044818)	3.08934308
34	axonemal dynein complex assembly (GO:0070286)	3.07333288
35	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.06520161
36	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	3.06055294
37	kinetochore assembly (GO:0051382)	3.03409688
38	postreplication repair (GO:0006301)	2.96051713
39	non-recombinational repair (GO:0000726)	2.92380535
40	double-strand break repair via nonhomologous end joining (GO:0006303)	2.92380535
41	DNA ligation (GO:0006266)	2.91586574
42	myelin assembly (GO:0032288)	2.90881680
43	regulation of oligodendrocyte differentiation (GO:0048713)	2.90101114
44	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.85800215
45	negative regulation of glial cell differentiation (GO:0045686)	2.85272635
46	adaptation of signaling pathway (GO:0023058)	2.84212455
47	DNA damage response, detection of DNA damage (GO:0042769)	2.83089160
48	DNA-dependent DNA replication (GO:0006261)	2.81867624
49	neuron fate determination (GO:0048664)	2.79897634
50	DNA replication checkpoint (GO:0000076)	2.78242519
51	somite development (GO:0061053)	2.78140540
52	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.77213159
53	urinary tract smooth muscle contraction (GO:0014848)	2.76800623
54	DNA strand renaturation (GO:0000733)	2.75226950
55	protein prenylation (GO:0018342)	2.74434975
56	prenylation (GO:0097354)	2.74434975
57	resolution of meiotic recombination intermediates (GO:0000712)	2.73287878
58	double-strand break repair via homologous recombination (GO:0000724)	2.71159640
59	negative regulation of thymocyte apoptotic process (GO:0070244)	2.70080987
60	recombinational repair (GO:0000725)	2.69079009
61	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.67993251
62	vascular smooth muscle contraction (GO:0014829)	2.67087731
63	synapsis (GO:0007129)	2.66700890
64	cilium morphogenesis (GO:0060271)	2.66536019
65	sister chromatid segregation (GO:0000819)	2.66458044
66	protein K11-linked deubiquitination (GO:0035871)	2.65753505
67	regulation of DNA-templated transcription, initiation (GO:2000142)	2.65228128
68	centriole assembly (GO:0098534)	2.64829398
69	olfactory bulb development (GO:0021772)	2.63808937
70	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.63606571
71	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.62397574
72	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.62397574
73	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.61002613
74	regulation of mitotic spindle checkpoint (GO:1903504)	2.61002613
75	centrosome organization (GO:0051297)	2.59807793
76	cilium movement (GO:0003341)	2.58374302
77	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.57182333
78	negative regulation of sister chromatid segregation (GO:0033046)	2.57182333
79	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.57182333
80	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.57182333
81	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.57182333
82	positive regulation of mRNA processing (GO:0050685)	2.56399533
83	seminiferous tubule development (GO:0072520)	2.55388416
84	pituitary gland development (GO:0021983)	2.54802212
85	sequestering of actin monomers (GO:0042989)	2.54505158
86	microtubule polymerization or depolymerization (GO:0031109)	2.53280565
87	microtubule nucleation (GO:0007020)	2.53260678
88	DNA catabolic process, exonucleolytic (GO:0000738)	2.52784032
89	spindle checkpoint (GO:0031577)	2.52689065
90	artery development (GO:0060840)	2.52544674
91	SMAD protein complex assembly (GO:0007183)	2.50132883
92	cell wall macromolecule catabolic process (GO:0016998)	2.49635544
93	regulation of centrosome duplication (GO:0010824)	2.49397732
94	microtubule organizing center organization (GO:0031023)	2.48520800
95	regulation of memory T cell differentiation (GO:0043380)	2.48378656
96	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.48363906
97	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.48363906
98	regulation of centrosome cycle (GO:0046605)	2.48257519
99	presynaptic membrane assembly (GO:0097105)	2.47855346
100	negative regulation of chromosome segregation (GO:0051985)	2.47765195

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.27920467
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.07882431
3	FUS_26573619_Chip-Seq_HEK293_Human	3.18889652
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16700196
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.02122945
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.00914550
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.83932707
8	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.79470076
9	EWS_26573619_Chip-Seq_HEK293_Human	2.70532273
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48258385
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.45713095
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.39051541
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.30422073
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.30330472
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.17064224
16	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.04452261
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97903246
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.95381946
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.93557100
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92981190
21	P300_19829295_ChIP-Seq_ESCs_Human	1.89749140
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.89661006
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.81013964
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.76349546
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73185028
26	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.59258384
27	EZH2_22144423_ChIP-Seq_EOC_Human	1.59057801
28	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.58125034
29	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.57187865
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56439084
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.55490622
32	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.52293272
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49850346
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47822155
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.47688615
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45933480
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.44794409
38	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.43638312
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.42140652
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40156849
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39865288
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38088832
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.37632131
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.35896646
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.35896646
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.33598723
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33598723
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.32107597
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32037462
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.29085419
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28433571
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27169001
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27096800
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25942332
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.25692151
56	MYC_18940864_ChIP-ChIP_HL60_Human	1.25225759
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24515359
58	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.23593304
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23127693
60	VDR_23849224_ChIP-Seq_CD4+_Human	1.22907894
61	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22264918
62	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22057444
63	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21468765
64	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.21249546
65	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20255100
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.19250930
67	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.18436855
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17933994
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.16289230
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.16029607
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15021143
72	P53_22387025_ChIP-Seq_ESCs_Mouse	1.14717183
73	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.13966268
74	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.13765931
75	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13270541
76	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.11730385
77	STAT3_23295773_ChIP-Seq_U87_Human	1.10529157
78	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.10053708
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09348055
80	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08684907
81	AR_25329375_ChIP-Seq_VCAP_Human	1.08279631
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06952739
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06064851
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06016871
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.05652878
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01676790
87	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01541258
88	CDX2_22108803_ChIP-Seq_LS180_Human	1.00513562
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00150825
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98945720
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97916366
92	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.96900140
93	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.96900140
94	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.96900140
95	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96882007
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96472167
97	TCF4_23295773_ChIP-Seq_U87_Human	0.95715898
98	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94788439
99	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.94520302
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.94259547

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.72424392
2	MP0008057_abnormal_DNA_replication	3.13022351
3	MP0008058_abnormal_DNA_repair	2.96795176
4	MP0010094_abnormal_chromosome_stability	2.94348565
5	MP0001984_abnormal_olfaction	2.45918769
6	MP0000049_abnormal_middle_ear	2.34029568
7	MP0008789_abnormal_olfactory_epithelium	2.17234672
8	MP0009697_abnormal_copulation	2.14858443
9	MP0001529_abnormal_vocalization	2.13229994
10	MP0003880_abnormal_central_pattern	2.08423212
11	MP0003787_abnormal_imprinting	2.00719136
12	MP0008877_abnormal_DNA_methylation	1.99522127
13	MP0001293_anophthalmia	1.98994144
14	MP0001485_abnormal_pinna_reflex	1.97207721
15	MP0005394_taste/olfaction_phenotype	1.88843184
16	MP0005499_abnormal_olfactory_system	1.88843184
17	MP0002653_abnormal_ependyma_morphology	1.83821165
18	MP0000372_irregular_coat_pigmentation	1.83817015
19	MP0002102_abnormal_ear_morphology	1.76284455
20	MP0003890_abnormal_embryonic-extraembry	1.73332915
21	MP0002938_white_spotting	1.71530895
22	MP0010030_abnormal_orbit_morphology	1.71013698
23	MP0008004_abnormal_stomach_pH	1.68807221
24	MP0001286_abnormal_eye_development	1.66850991
25	MP0003077_abnormal_cell_cycle	1.65784833
26	MP0002277_abnormal_respiratory_mucosa	1.60328325
27	MP0003937_abnormal_limbs/digits/tail_de	1.60244542
28	MP0008932_abnormal_embryonic_tissue	1.55667752
29	MP0003806_abnormal_nucleotide_metabolis	1.55094876
30	MP0003111_abnormal_nucleus_morphology	1.53531234
31	MP0006292_abnormal_olfactory_placode	1.51158594
32	MP0003693_abnormal_embryo_hatching	1.50816602
33	MP0000631_abnormal_neuroendocrine_gland	1.50627274
34	MP0002736_abnormal_nociception_after	1.50612430
35	MP0002751_abnormal_autonomic_nervous	1.43035900
36	MP0002233_abnormal_nose_morphology	1.42939337
37	MP0003122_maternal_imprinting	1.42938799
38	MP0003121_genomic_imprinting	1.40653266
39	MP0005410_abnormal_fertilization	1.40631211
40	MP0005464_abnormal_platelet_physiology	1.40052249
41	MP0004215_abnormal_myocardial_fiber	1.38688744
42	MP0001929_abnormal_gametogenesis	1.36749938
43	MP0004742_abnormal_vestibular_system	1.34478452
44	MP0005645_abnormal_hypothalamus_physiol	1.34182464
45	MP0005174_abnormal_tail_pigmentation	1.32423969
46	MP0004957_abnormal_blastocyst_morpholog	1.31331945
47	MP0005248_abnormal_Harderian_gland	1.28739633
48	MP0002697_abnormal_eye_size	1.22440240
49	MP0004142_abnormal_muscle_tone	1.20627247
50	MP0002210_abnormal_sex_determination	1.20379231
51	MP0003698_abnormal_male_reproductive	1.19698244
52	MP0001188_hyperpigmentation	1.19390900
53	MP0000778_abnormal_nervous_system	1.15564636
54	MP0004133_heterotaxia	1.14639989
55	MP0005084_abnormal_gallbladder_morpholo	1.13386510
56	MP0004885_abnormal_endolymph	1.12474162
57	MP0002638_abnormal_pupillary_reflex	1.09655034
58	MP0001145_abnormal_male_reproductive	1.09216503
59	MP0003724_increased_susceptibility_to	1.07997782
60	MP0000653_abnormal_sex_gland	1.04438718
61	MP0002095_abnormal_skin_pigmentation	1.03858893
62	MP0006276_abnormal_autonomic_nervous	1.02689167
63	MP0000428_abnormal_craniofacial_morphol	1.01167696
64	MP0005253_abnormal_eye_physiology	0.99124038
65	MP0003861_abnormal_nervous_system	0.98809004
66	MP0003763_abnormal_thymus_physiology	0.97683811
67	MP0000490_abnormal_crypts_of	0.97547010
68	MP0005187_abnormal_penis_morphology	0.96525664
69	MP0003755_abnormal_palate_morphology	0.96232854
70	MP0001968_abnormal_touch/_nociception	0.95631421
71	MP0001119_abnormal_female_reproductive	0.95383763
72	MP0001177_atelectasis	0.94211015
73	MP0003011_delayed_dark_adaptation	0.91958825
74	MP0002111_abnormal_tail_morphology	0.91874468
75	MP0002928_abnormal_bile_duct	0.90079475
76	MP0005391_vision/eye_phenotype	0.88359451
77	MP0003718_maternal_effect	0.87773265
78	MP0002084_abnormal_developmental_patter	0.86545694
79	MP0001849_ear_inflammation	0.86175458
80	MP0003315_abnormal_perineum_morphology	0.85999249
81	MP0001346_abnormal_lacrimal_gland	0.84077385
82	MP0000383_abnormal_hair_follicle	0.82564202
83	MP0000427_abnormal_hair_cycle	0.80521498
84	MP0003252_abnormal_bile_duct	0.79397309
85	MP0000703_abnormal_thymus_morphology	0.77248752
86	MP0002085_abnormal_embryonic_tissue	0.75625017
87	MP0001697_abnormal_embryo_size	0.74580707
88	MP0002735_abnormal_chemical_nociception	0.74495681
89	MP0002160_abnormal_reproductive_system	0.74021494
90	MP0010678_abnormal_skin_adnexa	0.73545441
91	MP0006072_abnormal_retinal_apoptosis	0.73449322
92	MP0005389_reproductive_system_phenotype	0.73362544
93	MP0000230_abnormal_systemic_arterial	0.73066026
94	MP0005075_abnormal_melanosome_morpholog	0.73055650
95	MP0008007_abnormal_cellular_replicative	0.72671779
96	MP0005171_absent_coat_pigmentation	0.71497092
97	MP0009703_decreased_birth_body	0.70740921
98	MP0002752_abnormal_somatic_nervous	0.69607557
99	MP0008775_abnormal_heart_ventricle	0.69100166
100	MP0004084_abnormal_cardiac_muscle	0.68747188

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	4.22306037
2	Dyschromatopsia (HP:0007641)	3.71676210
3	True hermaphroditism (HP:0010459)	3.14657361
4	Pancreatic fibrosis (HP:0100732)	3.12115441
5	Abnormality of chromosome stability (HP:0003220)	3.05296930
6	Tubulointerstitial nephritis (HP:0001970)	2.94218801
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.92924767
8	Bile duct proliferation (HP:0001408)	2.88133994
9	Abnormal biliary tract physiology (HP:0012439)	2.88133994
10	Anophthalmia (HP:0000528)	2.84184233
11	Pancreatic cysts (HP:0001737)	2.66886372
12	Atonic seizures (HP:0010819)	2.66588904
13	Optic nerve hypoplasia (HP:0000609)	2.64542507
14	Intestinal atresia (HP:0011100)	2.62513815
15	Colon cancer (HP:0003003)	2.61960304
16	Hypoplastic pelvis (HP:0008839)	2.60484194
17	Hip dysplasia (HP:0001385)	2.55699355
18	Meckel diverticulum (HP:0002245)	2.55653134
19	Postaxial foot polydactyly (HP:0001830)	2.52240601
20	Abnormality of the labia minora (HP:0012880)	2.50914114
21	Growth hormone deficiency (HP:0000824)	2.48310565
22	Genital tract atresia (HP:0001827)	2.45897767
23	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.45787336
24	Chromsome breakage (HP:0040012)	2.43428290
25	Abnormality of the ileum (HP:0001549)	2.40357206
26	Medial flaring of the eyebrow (HP:0010747)	2.40303867
27	Anencephaly (HP:0002323)	2.40270016
28	Nephronophthisis (HP:0000090)	2.39891709
29	Abnormal auditory evoked potentials (HP:0006958)	2.38720443
30	Aqueductal stenosis (HP:0002410)	2.38631716
31	Bifid tongue (HP:0010297)	2.38132185
32	Rib fusion (HP:0000902)	2.37286652
33	Abnormality of lateral ventricle (HP:0030047)	2.37198039
34	Abnormal lung lobation (HP:0002101)	2.33418487
35	Vaginal atresia (HP:0000148)	2.32383393
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31254825
37	Thyroiditis (HP:0100646)	2.29458339
38	Gonadotropin excess (HP:0000837)	2.27409553
39	Abnormality of midbrain morphology (HP:0002418)	2.26140168
40	Molar tooth sign on MRI (HP:0002419)	2.26140168
41	Maternal diabetes (HP:0009800)	2.24907397
42	Chronic hepatic failure (HP:0100626)	2.24132431
43	Congenital primary aphakia (HP:0007707)	2.20831253
44	Sloping forehead (HP:0000340)	2.20082780
45	Increased mean platelet volume (HP:0011877)	2.19840740
46	Renal hypoplasia (HP:0000089)	2.19184784
47	Gait imbalance (HP:0002141)	2.18216363
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.16792769
49	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16792769
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.14488694
51	Severe combined immunodeficiency (HP:0004430)	2.10261041
52	Postaxial hand polydactyly (HP:0001162)	2.09205158
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07810327
54	Abnormality of the duodenum (HP:0002246)	2.07691679
55	Triphalangeal thumb (HP:0001199)	2.07203133
56	Gastrointestinal atresia (HP:0002589)	2.06971639
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06282953
58	Renal cortical cysts (HP:0000803)	2.05231461
59	Sclerocornea (HP:0000647)	2.04847283
60	Short middle phalanx of the 5th finger (HP:0004220)	2.04283762
61	Morphological abnormality of the inner ear (HP:0011390)	2.03247766
62	Absent septum pellucidum (HP:0001331)	2.00369430
63	Abnormal platelet volume (HP:0011876)	2.00259816
64	Nephrogenic diabetes insipidus (HP:0009806)	1.99560623
65	Volvulus (HP:0002580)	1.98946910
66	Narrow forehead (HP:0000341)	1.98519469
67	Prolonged bleeding time (HP:0003010)	1.97662112
68	Poikilocytosis (HP:0004447)	1.96475519
69	Abnormality of the septum pellucidum (HP:0007375)	1.92891749
70	Poor coordination (HP:0002370)	1.91664204
71	Esophageal atresia (HP:0002032)	1.89636092
72	Abnormality of the preputium (HP:0100587)	1.88154263
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.88092048
74	Absent/shortened dynein arms (HP:0200106)	1.88092048
75	Abnormality of the renal medulla (HP:0100957)	1.88088562
76	Abolished electroretinogram (ERG) (HP:0000550)	1.88011888
77	Panhypogammaglobulinemia (HP:0003139)	1.86449494
78	Male pseudohermaphroditism (HP:0000037)	1.85082560
79	Clubbing of toes (HP:0100760)	1.83541167
80	Thyroid-stimulating hormone excess (HP:0002925)	1.82631463
81	Abnormal number of erythroid precursors (HP:0012131)	1.82171355
82	Congenital stationary night blindness (HP:0007642)	1.81091749
83	Cortical dysplasia (HP:0002539)	1.80842386
84	Ectopic kidney (HP:0000086)	1.80236124
85	Absent thumb (HP:0009777)	1.78712820
86	Small intestinal stenosis (HP:0012848)	1.78686032
87	Duodenal stenosis (HP:0100867)	1.78686032
88	Combined immunodeficiency (HP:0005387)	1.78052366
89	Myelomeningocele (HP:0002475)	1.78024478
90	Micropenis (HP:0000054)	1.77749257
91	Cutaneous finger syndactyly (HP:0010554)	1.76487727
92	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.75148865
93	Abnormal hair whorl (HP:0010721)	1.74237604
94	Midline defect of the nose (HP:0004122)	1.72767648
95	Preaxial hand polydactyly (HP:0001177)	1.71899933
96	Missing ribs (HP:0000921)	1.71835627
97	Abnormality of the renal cortex (HP:0011035)	1.71695431
98	Chorioretinal coloboma (HP:0000567)	1.71558270
99	Abnormality of cells of the erythroid lineage (HP:0012130)	1.71425634
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.68855653

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.68289649
2	CDC7	3.30299824
3	FRK	3.25677118
4	MKNK2	3.03946010
5	WNK3	2.89350424
6	BRSK2	2.75074917
7	MKNK1	2.69466211
8	PNCK	2.67752371
9	PINK1	2.58300085
10	WEE1	2.54841794
11	MAP3K4	2.44958122
12	PLK4	2.33760585
13	NUAK1	2.27359083
14	PLK3	1.98701779
15	MAP2K7	1.74267293
16	STK39	1.65367162
17	WNK4	1.62072391
18	MST4	1.55191792
19	LATS1	1.53412348
20	ZAK	1.51610956
21	EIF2AK3	1.51002823
22	FGFR2	1.48401406
23	MARK3	1.45641001
24	NLK	1.39942989
25	TRIM28	1.37283335
26	DYRK3	1.36351128
27	BRD4	1.32817291
28	MAPK13	1.32636335
29	STK3	1.30852243
30	CDK3	1.27801487
31	EIF2AK1	1.25915277
32	TTK	1.24176332
33	BMPR1B	1.20990749
34	PASK	1.19971738
35	VRK1	1.19508462
36	ERBB3	1.16771459
37	TGFBR1	1.15789331
38	PRKCQ	1.06064334
39	DYRK2	1.05922658
40	NEK2	0.99157282
41	AKT3	0.98928031
42	TAOK3	0.98069293
43	FGFR1	0.96232531
44	BUB1	0.94868393
45	BRSK1	0.93950743
46	PLK1	0.92109737
47	SRPK1	0.91257998
48	PRKCG	0.90354834
49	TEC	0.87917014
50	CHEK2	0.85679119
51	ATR	0.83875660
52	TAF1	0.82339901
53	PIK3CG	0.81226447
54	CLK1	0.73869375
55	ATM	0.73267267
56	STK38L	0.71681943
57	PIK3CA	0.70954080
58	BCR	0.70932841
59	BTK	0.67509226
60	CSNK1G1	0.64711975
61	ACVR1B	0.64565593
62	OBSCN	0.64049572
63	MAP2K4	0.62573344
64	MAP3K10	0.59251946
65	TXK	0.58793515
66	SGK2	0.58108347
67	MAPK15	0.58091916
68	PLK2	0.56472704
69	MAP3K5	0.53143837
70	CASK	0.51769242
71	BRAF	0.51158052
72	WNK1	0.51027335
73	DYRK1A	0.50012444
74	PRKCE	0.49582052
75	PTK2B	0.49349706
76	PKN1	0.49299271
77	SYK	0.49237226
78	YES1	0.48612275
79	TRPM7	0.45102870
80	MAP3K6	0.44856420
81	GRK1	0.42695797
82	TLK1	0.42157645
83	CSNK1G2	0.41784972
84	AURKB	0.40749561
85	RPS6KA4	0.36912447
86	GRK6	0.35960175
87	CHEK1	0.34589153
88	ADRBK2	0.34266356
89	SGK3	0.33581482
90	RPS6KB1	0.32139727
91	STK24	0.31746776
92	CSF1R	0.31736734
93	DYRK1B	0.30542436
94	FGR	0.29376020
95	CSNK1G3	0.28746674
96	PRKCB	0.28622383
97	TSSK6	0.27368218
98	STK11	0.26813253
99	SGK494	0.25200428
100	SGK223	0.25200428

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.80453268
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.79452416
3	Non-homologous end-joining_Homo sapiens_hsa03450	3.76711632
4	Mismatch repair_Homo sapiens_hsa03430	3.30565590
5	Homologous recombination_Homo sapiens_hsa03440	2.87528855
6	Basal transcription factors_Homo sapiens_hsa03022	2.61883128
7	Butanoate metabolism_Homo sapiens_hsa00650	2.36274212
8	DNA replication_Homo sapiens_hsa03030	2.34720123
9	Steroid biosynthesis_Homo sapiens_hsa00100	2.03423561
10	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.98919768
11	Nucleotide excision repair_Homo sapiens_hsa03420	1.88019669
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.87031712
13	RNA degradation_Homo sapiens_hsa03018	1.83642201
14	Spliceosome_Homo sapiens_hsa03040	1.79610000
15	RNA transport_Homo sapiens_hsa03013	1.79533485
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.78188651
17	Cell cycle_Homo sapiens_hsa04110	1.74305865
18	Protein export_Homo sapiens_hsa03060	1.68193171
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60755851
20	One carbon pool by folate_Homo sapiens_hsa00670	1.49466966
21	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.44334110
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.39499090
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37971497
24	Basal cell carcinoma_Homo sapiens_hsa05217	1.36772295
25	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.35096164
26	Phototransduction_Homo sapiens_hsa04744	1.33469757
27	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.28964472
28	Platelet activation_Homo sapiens_hsa04611	1.25196028
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.20011406
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16336453
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11092757
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.11050884
33	Olfactory transduction_Homo sapiens_hsa04740	1.10946869
34	mRNA surveillance pathway_Homo sapiens_hsa03015	1.10350627
35	Propanoate metabolism_Homo sapiens_hsa00640	1.10089364
36	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.08785069
37	Wnt signaling pathway_Homo sapiens_hsa04310	1.03790070
38	Base excision repair_Homo sapiens_hsa03410	1.03441880
39	Gap junction_Homo sapiens_hsa04540	1.00053466
40	RNA polymerase_Homo sapiens_hsa03020	0.97907943
41	p53 signaling pathway_Homo sapiens_hsa04115	0.96918560
42	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96813950
43	Purine metabolism_Homo sapiens_hsa00230	0.94181117
44	Taste transduction_Homo sapiens_hsa04742	0.90518116
45	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.88111926
46	Hippo signaling pathway_Homo sapiens_hsa04390	0.88005541
47	Circadian rhythm_Homo sapiens_hsa04710	0.83336508
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.81121719
49	Linoleic acid metabolism_Homo sapiens_hsa00591	0.77878063
50	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.76729226
51	Colorectal cancer_Homo sapiens_hsa05210	0.73716726
52	Alcoholism_Homo sapiens_hsa05034	0.71214216
53	Ribosome_Homo sapiens_hsa03010	0.69982417
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.68848962
55	Prostate cancer_Homo sapiens_hsa05215	0.66997444
56	FoxO signaling pathway_Homo sapiens_hsa04068	0.65659694
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.65280840
58	Serotonergic synapse_Homo sapiens_hsa04726	0.64880022
59	Melanoma_Homo sapiens_hsa05218	0.64097972
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62173343
61	Oocyte meiosis_Homo sapiens_hsa04114	0.60440287
62	Fatty acid elongation_Homo sapiens_hsa00062	0.59938071
63	Renin secretion_Homo sapiens_hsa04924	0.56945693
64	Folate biosynthesis_Homo sapiens_hsa00790	0.55157944
65	Proteasome_Homo sapiens_hsa03050	0.52757669
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.52271982
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.52073443
68	Endometrial cancer_Homo sapiens_hsa05213	0.50000410
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48011656
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47154514
71	Peroxisome_Homo sapiens_hsa04146	0.47111543
72	GABAergic synapse_Homo sapiens_hsa04727	0.45978961
73	Axon guidance_Homo sapiens_hsa04360	0.45585027
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45474432
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44086593
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42769436
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42532755
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40879916
79	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.40246686
80	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.39428092
81	Circadian entrainment_Homo sapiens_hsa04713	0.38330118
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.37468066
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37301656
84	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36415512
85	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34795384
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.34105516
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33018137
88	Adherens junction_Homo sapiens_hsa04520	0.32960930
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.31605979
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30634842
91	Retinol metabolism_Homo sapiens_hsa00830	0.30110853
92	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.29871951
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26167013
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25917737
95	Nicotine addiction_Homo sapiens_hsa05033	0.25815705
96	Measles_Homo sapiens_hsa05162	0.25546638
97	Herpes simplex infection_Homo sapiens_hsa05168	0.24930960
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.24016426
99	Pathways in cancer_Homo sapiens_hsa05200	0.23959495
100	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.22634081

KLRA1P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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