KLRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.39349059
2cell wall macromolecule metabolic process (GO:0044036)8.64188185
3cell wall macromolecule catabolic process (GO:0016998)8.64188185
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.19083872
5negative regulation of cell killing (GO:0031342)8.19083872
6multicellular organism reproduction (GO:0032504)7.86487026
7cellular response to interleukin-15 (GO:0071350)7.36657610
8protein-chromophore linkage (GO:0018298)6.99652332
9plasma membrane fusion (GO:0045026)6.79008113
10sperm motility (GO:0030317)6.66034532
11reproduction (GO:0000003)6.47709074
12response to interleukin-15 (GO:0070672)6.47436563
13male meiosis (GO:0007140)6.28244466
14tolerance induction (GO:0002507)6.09142327
15acrosome reaction (GO:0007340)6.00663865
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78119724
17regulation of memory T cell differentiation (GO:0043380)5.67373906
18acrosome assembly (GO:0001675)5.51516903
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.51051804
20single fertilization (GO:0007338)5.48959063
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.48346968
22DNA methylation involved in gamete generation (GO:0043046)5.38239562
23negative T cell selection (GO:0043383)5.34440115
24regulation of T cell mediated cytotoxicity (GO:0001914)5.30284942
25regulation of B cell receptor signaling pathway (GO:0050855)5.29316962
26sperm-egg recognition (GO:0035036)5.24659341
27protein K6-linked ubiquitination (GO:0085020)5.22015518
28sleep (GO:0030431)5.04829690
29positive regulation of T cell mediated cytotoxicity (GO:0001916)4.93531318
30negative thymic T cell selection (GO:0045060)4.91226233
31fertilization (GO:0009566)4.89501766
32antigen processing and presentation of endogenous antigen (GO:0019883)4.85055054
33synaptonemal complex organization (GO:0070193)4.83965066
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81869341
35epithelial cilium movement (GO:0003351)4.80722098
36binding of sperm to zona pellucida (GO:0007339)4.69699786
37motile cilium assembly (GO:0044458)4.68406682
38synaptonemal complex assembly (GO:0007130)4.68148477
39citrulline biosynthetic process (GO:0019240)4.65897992
40cell-cell recognition (GO:0009988)4.65341848
41regulation of leukocyte mediated cytotoxicity (GO:0001910)4.63197874
42regulation of activation of Janus kinase activity (GO:0010533)4.60269496
43spermatid development (GO:0007286)4.59991774
44positive regulation of defense response to virus by host (GO:0002230)4.51178634
45regulation of gamma-delta T cell differentiation (GO:0045586)4.50902903
46GTP biosynthetic process (GO:0006183)4.48451437
47regulation of regulatory T cell differentiation (GO:0045589)4.42654793
48regulation of female gonad development (GO:2000194)4.38473289
49negative regulation of T cell mediated immunity (GO:0002710)4.37134835
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.34359549
51negative regulation of inclusion body assembly (GO:0090084)4.32839962
52positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.27822670
53microtubule severing (GO:0051013)4.25497048
54oocyte maturation (GO:0001556)4.24736371
55positive regulation of gamma-delta T cell activation (GO:0046645)4.24549992
56regulation of cell killing (GO:0031341)4.23156811
57T-helper cell differentiation (GO:0042093)4.18919320
58CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.18919320
59cilium movement (GO:0003341)4.17224301
60cilium or flagellum-dependent cell motility (GO:0001539)4.14405636
61microtubule depolymerization (GO:0007019)4.13859664
62histone H2A monoubiquitination (GO:0035518)4.13184886
63mast cell activation (GO:0045576)4.13112626
64mast cell degranulation (GO:0043303)4.09767396
65mast cell activation involved in immune response (GO:0002279)4.09767396
66negative regulation of lymphocyte mediated immunity (GO:0002707)4.08736346
67regulation of natural killer cell mediated immunity (GO:0002715)4.07417798
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.07417798
69diol metabolic process (GO:0034311)4.07243396
70female gamete generation (GO:0007292)4.05081158
71positive regulation of T cell differentiation in thymus (GO:0033089)4.04685527
72positive regulation of T cell mediated immunity (GO:0002711)4.03668613
73positive thymic T cell selection (GO:0045059)3.98193712
74positive T cell selection (GO:0043368)3.97855746
75regulation of gamma-delta T cell activation (GO:0046643)3.96517304
76negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.94138549
77ovulation cycle (GO:0042698)3.93723358
78antigen processing and presentation via MHC class Ib (GO:0002475)3.92362836
79lymph node development (GO:0048535)3.91858257
80regulation of T cell mediated immunity (GO:0002709)3.89862281
81response to muramyl dipeptide (GO:0032495)3.86362353
82positive regulation of cell killing (GO:0031343)3.86205617
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.86106336
84positive regulation of alpha-beta T cell proliferation (GO:0046641)3.83585364
85UTP biosynthetic process (GO:0006228)3.83452291
86histone H2A ubiquitination (GO:0033522)3.80856887
87thymic T cell selection (GO:0045061)3.80301044
88T cell differentiation involved in immune response (GO:0002292)3.78079902
89alpha-beta T cell differentiation involved in immune response (GO:0002293)3.78079902
90alpha-beta T cell activation involved in immune response (GO:0002287)3.78079902
91negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77848022
92cytidine metabolic process (GO:0046087)3.77526176
93cytidine catabolic process (GO:0006216)3.77526176
94cytidine deamination (GO:0009972)3.77526176
95regulation of alpha-beta T cell proliferation (GO:0046640)3.75115318
96interferon-gamma secretion (GO:0072643)3.73275774
97axonemal dynein complex assembly (GO:0070286)3.71499022
98regulation of germinal center formation (GO:0002634)3.67009556
99negative regulation of smooth muscle cell differentiation (GO:0051151)3.66698511
100positive regulation of natural killer cell mediated immunity (GO:0002717)3.66601589
101regulation of cilium movement (GO:0003352)3.65939145
102negative regulation of leukocyte mediated immunity (GO:0002704)3.63385274
103pyrimidine ribonucleoside catabolic process (GO:0046133)3.58932630
104regulation of T cell receptor signaling pathway (GO:0050856)3.58923106
105sperm capacitation (GO:0048240)3.58873497
106gamete generation (GO:0007276)3.57724755
107regulation of defense response to virus by host (GO:0050691)3.57621702
108regulation of T-helper 1 type immune response (GO:0002825)3.57497090
109spermatogenesis (GO:0007283)3.56291092
110sphingosine metabolic process (GO:0006670)3.55697311
111T cell selection (GO:0045058)3.54832303
112male gamete generation (GO:0048232)3.54669738
113dendritic cell chemotaxis (GO:0002407)3.53533800
114meiotic cell cycle (GO:0051321)3.53393566
115gene silencing by RNA (GO:0031047)3.53047312
116regulation of meiosis (GO:0040020)3.52645764
117CTP metabolic process (GO:0046036)3.50386764
118CTP biosynthetic process (GO:0006241)3.50386764
119regulation of meiotic cell cycle (GO:0051445)3.49945756
120positive regulation of interleukin-17 production (GO:0032740)3.47174651
121negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.46345402
122chromosome organization involved in meiosis (GO:0070192)3.45144503
123left/right axis specification (GO:0070986)3.41812224
124T cell migration (GO:0072678)3.40854832
125positive regulation of T-helper 1 type immune response (GO:0002827)3.40466543
126positive regulation of T cell cytokine production (GO:0002726)3.40360585
127negative regulation of T cell apoptotic process (GO:0070233)3.39950694
128negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.39210175
129UTP metabolic process (GO:0046051)3.36961314
130leukocyte aggregation (GO:0070486)3.36874076
131regulation of corticosteroid hormone secretion (GO:2000846)3.36327725
132regulation of glycogen (starch) synthase activity (GO:2000465)3.36033102
133DNA deamination (GO:0045006)3.34435065
134interferon-gamma production (GO:0032609)3.32996672
135regulation of sister chromatid cohesion (GO:0007063)3.32955744
136leukocyte degranulation (GO:0043299)3.32762186
137negative regulation of innate immune response (GO:0045824)3.32180376
138alpha-beta T cell differentiation (GO:0046632)3.31742161
139RNA destabilization (GO:0050779)3.31116321
140sphingoid metabolic process (GO:0046519)3.29258197
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.28489786
142negative regulation of T-helper cell differentiation (GO:0045623)3.28489786
143meiotic chromosome segregation (GO:0045132)3.28111866
144positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.27760467
145negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.27079889
146pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.26666908
147regulation of chronic inflammatory response (GO:0002676)3.26487631
148cellular defense response (GO:0006968)3.24068307
149regulation of inclusion body assembly (GO:0090083)3.22495313
150positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.21825743
151male meiosis I (GO:0007141)3.21784740
152cellular process involved in reproduction in multicellular organism (GO:0022412)3.21780459
153alpha-beta T cell activation (GO:0046631)3.21753472
154positive regulation of osteoclast differentiation (GO:0045672)3.19847950
155positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.19125567
156mitotic chromosome condensation (GO:0007076)3.17053893
157neutrophil activation (GO:0042119)3.15378008
158natural killer cell activation (GO:0030101)3.13784948
159DNA damage induced protein phosphorylation (GO:0006975)3.13493379
160regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.13330601
161mitotic sister chromatid cohesion (GO:0007064)3.12946525
162regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.10639586
163CD4-positive, alpha-beta T cell activation (GO:0035710)3.10540004
164regulation of isotype switching to IgG isotypes (GO:0048302)3.09945569
165glycerophospholipid catabolic process (GO:0046475)3.09303347
166pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.09258369
167dendritic cell migration (GO:0036336)3.08572140
168positive regulation of lymphocyte mediated immunity (GO:0002708)3.06449517
169negative regulation of circadian rhythm (GO:0042754)3.06194321
170positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.05723164
171positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.05723164
172positive regulation of mitotic sister chromatid separation (GO:1901970)3.05723164
173regulation of histone H3-K27 methylation (GO:0061085)3.05668591
174nucleoside diphosphate phosphorylation (GO:0006165)3.05626581
175T cell receptor signaling pathway (GO:0050852)3.04532948
176tumor necrosis factor-mediated signaling pathway (GO:0033209)3.04529396
177protein localization to chromosome, centromeric region (GO:0071459)3.03967043
178negative regulation of interleukin-10 production (GO:0032693)3.03146287
179phosphatidylglycerol biosynthetic process (GO:0006655)3.02624968
180pyrimidine nucleotide catabolic process (GO:0006244)3.02486600
181cellular response to pH (GO:0071467)3.00810615
182meiotic nuclear division (GO:0007126)2.96104200
183oocyte development (GO:0048599)2.96095473
184polyamine biosynthetic process (GO:0006596)2.96029041
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93752829
186negative regulation of organelle assembly (GO:1902116)2.92794334
187multicellular organismal reproductive process (GO:0048609)2.92652787
188regulation of steroid hormone secretion (GO:2000831)2.91271304
189female gonad development (GO:0008585)2.89760691
190negative regulation of meiotic cell cycle (GO:0051447)2.89645784
191glycerol ether metabolic process (GO:0006662)2.85554201
192resolution of meiotic recombination intermediates (GO:0000712)2.85375428
193regulation of DNA damage checkpoint (GO:2000001)2.84312755
194citrulline metabolic process (GO:0000052)2.83905077
195cGMP-mediated signaling (GO:0019934)2.83794908
196calcium ion-dependent exocytosis (GO:0017156)2.83731539
197proline transport (GO:0015824)2.83672876
198regulation of glucocorticoid secretion (GO:2000849)2.82120358
199germ cell development (GO:0007281)2.80695896
200piRNA metabolic process (GO:0034587)10.3260111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.77397351
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.62972995
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.83992069
4RUNX_20019798_ChIP-Seq_JUKART_Human4.63132973
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.73988458
6MYB_26560356_Chip-Seq_TH2_Human3.45229676
7FLI1_27457419_Chip-Seq_LIVER_Mouse3.38688831
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.22788541
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.15148279
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.90556022
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.89360868
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88675232
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.86034983
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83086660
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.82385741
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67686356
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.66893429
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60996646
19EZH2_22144423_ChIP-Seq_EOC_Human2.59796995
20GATA3_27048872_Chip-Seq_THYMUS_Human2.56146494
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54098872
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.45452091
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41395270
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40580324
25SUZ12_27294783_Chip-Seq_NPCs_Mouse2.38680660
26MYB_26560356_Chip-Seq_TH1_Human2.37985286
27GATA3_26560356_Chip-Seq_TH2_Human2.37304163
28KAP1_22055183_ChIP-Seq_ESCs_Mouse2.37039435
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31714125
30NFE2_27457419_Chip-Seq_LIVER_Mouse2.29928715
31UTX_26944678_Chip-Seq_JUKART_Human2.23826220
32SCL_19346495_ChIP-Seq_HPC-7_Human2.19656144
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18364996
34MAF_26560356_Chip-Seq_TH1_Human2.17161489
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15204388
36GATA1_22025678_ChIP-Seq_K562_Human2.12409743
37STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10626826
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.05779436
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03482077
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02216723
41RNF2_27304074_Chip-Seq_NSC_Mouse2.02162848
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.98189640
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97183569
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.95380204
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.94741678
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91942228
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88331072
48SUZ12_18555785_Chip-Seq_ESCs_Mouse1.87681748
49STAT1_17558387_ChIP-Seq_HELA_Human1.87105368
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.86616718
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.80510103
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.80175498
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.79709409
54MAF_26560356_Chip-Seq_TH2_Human1.78181013
55P53_22387025_ChIP-Seq_ESCs_Mouse1.76757319
56SPI1_23547873_ChIP-Seq_NB4_Human1.74957297
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72019549
58KDM2B_26808549_Chip-Seq_REH_Human1.71219577
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.71158619
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.68290541
61P300_18555785_Chip-Seq_ESCs_Mouse1.67344425
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.66943008
63NMYC_18555785_Chip-Seq_ESCs_Mouse1.65065538
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64858202
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.63388407
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.61675919
67OCT4_18555785_Chip-Seq_ESCs_Mouse1.59510982
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.58600998
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.54079596
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52081396
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51981758
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.51164227
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.51133407
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.50197684
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49620282
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.49607986
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48866219
78ESRRB_18555785_Chip-Seq_ESCs_Mouse1.48837528
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.48269855
80IRF1_19129219_ChIP-ChIP_H3396_Human1.47849173
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45328864
82CTCF_18555785_Chip-Seq_ESCs_Mouse1.42597534
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35388757
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34558534
85ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33559417
86SMAD1_18555785_Chip-Seq_ESCs_Mouse1.32091206
87IGF1R_20145208_ChIP-Seq_DFB_Human1.31624846
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.31450608
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30484823
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30452673
91NFYA_21822215_ChIP-Seq_K562_Human1.29207639
92PU1_27457419_Chip-Seq_LIVER_Mouse1.29016521
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.28937273
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28433647
95WDR5_24793694_ChIP-Seq_LNCAP_Human1.27783484
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27503950
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25938301
98TBL1_22424771_ChIP-Seq_293T_Human1.23382807
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22607010
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22291846
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22062301
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21212865
103BP1_19119308_ChIP-ChIP_Hs578T_Human1.20699107
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19904834
105NFYB_21822215_ChIP-Seq_K562_Human1.17849998
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17499959
107ETV1_20927104_ChIP-Seq_GIST48_Human1.17137965
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17025547
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17025547
110TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16127091
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14771832
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13475501
113HNFA_21074721_ChIP-Seq_CACO-2_Human1.12309834
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12053863
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11957972
116GATA3_26560356_Chip-Seq_TH1_Human1.11798400
117CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11782113
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11294475
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11221873
120VDR_22108803_ChIP-Seq_LS180_Human1.11129115
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09978190
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09918460
123CDX2_22108803_ChIP-Seq_LS180_Human1.09871582
124TCF4_18268006_ChIP-ChIP_LS174T_Human1.09062110
125SPI1_23127762_ChIP-Seq_K562_Human1.08289929
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07107798
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05665415
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04953333
129CJUN_26792858_Chip-Seq_BT549_Human1.03318214
130VDR_24787735_ChIP-Seq_THP-1_Human1.02833634
131CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02454954
132* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02317688
133GF1B_26923725_Chip-Seq_HPCs_Mouse1.02133728
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02094417
135GATA6_21074721_ChIP-Seq_CACO-2_Human1.02055659
136NANOG_19829295_ChIP-Seq_ESCs_Human1.02008854
137SOX2_19829295_ChIP-Seq_ESCs_Human1.02008854
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01870639
139VDR_23849224_ChIP-Seq_CD4+_Human1.01757718
140PHF8_20622853_ChIP-Seq_HELA_Human1.01337383
141BCL6_27268052_Chip-Seq_Bcells_Human1.00713255
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99956223
143STAT1_20625510_ChIP-Seq_HELA_Human0.99219340
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98834210
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98507860
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.97996884
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96489002
148PU_27001747_Chip-Seq_BMDM_Mouse0.96132081
149SMAD4_21799915_ChIP-Seq_A2780_Human0.96090914
150MYC_22102868_ChIP-Seq_BL_Human0.96039039
151FOXM1_23109430_ChIP-Seq_U2OS_Human0.95983262
152GF1_26923725_Chip-Seq_HPCs_Mouse0.95696028
153PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95133114
154EZH2_27304074_Chip-Seq_ESCs_Mouse0.95090334
155P300_19829295_ChIP-Seq_ESCs_Human0.94835909
156STAT3_23295773_ChIP-Seq_U87_Human0.94527630
157SOX2_22085726_ChIP-Seq_NPCs_Mouse0.94156206
158GATA2_21666600_ChIP-Seq_HMVEC_Human0.93748023
159RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93741558
160SMAD_19615063_ChIP-ChIP_OVARY_Human0.93530574
161TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90233716
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88983572
163EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87946318
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87247958
165FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87237546
166VDR_24763502_ChIP-Seq_THP-1_Human0.86441830
167PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86201157
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85691752
169CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85621838
170GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84069601
171P300_27268052_Chip-Seq_Bcells_Human0.83942600
172EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83102716
173PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83048487
174RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81705918
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81393410
176ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81238329
177Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79844818
178GATA1_19941827_ChIP-Seq_MEL_Mouse0.79783359
179* SMRT_27268052_Chip-Seq_Bcells_Human0.78238413
180SPI1_20517297_ChIP-Seq_HL60_Human0.77887441
181SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77568498
182BCOR_27268052_Chip-Seq_Bcells_Human0.75613280
183* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75609147
184NANOG_20526341_ChIP-Seq_ESCs_Human0.75166910
185BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73914967
186* PRDM14_20953172_ChIP-Seq_ESCs_Human0.72814057
187FOXP3_21729870_ChIP-Seq_TREG_Human0.70971369
188CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69855313
189ETS1_21867929_ChIP-Seq_TH2_Mouse0.68488785
190TP53_22573176_ChIP-Seq_HFKS_Human0.67626997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.73979133
2MP0003724_increased_susceptibility_to4.71518858
3MP0005451_abnormal_body_composition4.37253609
4MP0003646_muscle_fatigue4.36662260
5MP0008877_abnormal_DNA_methylation4.28611864
6MP0003718_maternal_effect3.74614697
7MP0003436_decreased_susceptibility_to3.68417083
8MP0000569_abnormal_digit_pigmentation3.60247069
9MP0002009_preneoplasia3.57209776
10MP0001835_abnormal_antigen_presentation3.38902810
11MP0001929_abnormal_gametogenesis3.36487975
12MP0000579_abnormal_nail_morphology3.35282501
13MP0003315_abnormal_perineum_morphology2.89956288
14MP0000685_abnormal_immune_system2.82057312
15MP0009785_altered_susceptibility_to2.80302289
16MP0002877_abnormal_melanocyte_morpholog2.76921310
17MP0005646_abnormal_pituitary_gland2.71126908
18MP0003698_abnormal_male_reproductive2.57954472
19MP0002210_abnormal_sex_determination2.44104617
20MP0005025_abnormal_response_to2.38707465
21MP0002148_abnormal_hypersensitivity_rea2.34762669
22MP0009384_cardiac_valve_regurgitation2.27318466
23MP0002419_abnormal_innate_immunity2.24217525
24MP0009379_abnormal_foot_pigmentation2.23398801
25MP0002933_joint_inflammation2.22043875
26MP0005360_urolithiasis2.19138909
27MP0002405_respiratory_system_inflammati2.16552077
28MP0003866_abnormal_defecation2.16078554
29MP0003941_abnormal_skin_development2.15806836
30MP0001533_abnormal_skeleton_physiology2.13816983
31MP0003950_abnormal_plasma_membrane2.12657906
32MP0004947_skin_inflammation2.11544937
33MP0002398_abnormal_bone_marrow2.11234044
34MP0005075_abnormal_melanosome_morpholog2.09920240
35MP0004185_abnormal_adipocyte_glucose2.06306909
36MP0009333_abnormal_splenocyte_physiolog2.02161615
37MP0000716_abnormal_immune_system2.01400053
38MP0001119_abnormal_female_reproductive2.00750956
39MP0000703_abnormal_thymus_morphology1.99788228
40MP0010155_abnormal_intestine_physiology1.98191946
41MP0000653_abnormal_sex_gland1.97476273
42MP0002295_abnormal_pulmonary_circulatio1.95676754
43MP0002161_abnormal_fertility/fecundity1.94305931
44MP0003300_gastrointestinal_ulcer1.92404112
45MP0000689_abnormal_spleen_morphology1.86435652
46MP0002722_abnormal_immune_system1.85647147
47MP0003699_abnormal_female_reproductive1.78009578
48MP0001845_abnormal_inflammatory_respons1.67471892
49MP0001145_abnormal_male_reproductive1.62694861
50MP0005647_abnormal_sex_gland1.59992952
51MP0002429_abnormal_blood_cell1.56641476
52MP0001853_heart_inflammation1.56600418
53MP0003787_abnormal_imprinting1.54993390
54MP0005257_abnormal_intraocular_pressure1.54330170
55MP0000015_abnormal_ear_pigmentation1.52814230
56MP0002876_abnormal_thyroid_physiology1.50941210
57MP0005395_other_phenotype1.48219986
58MP0005379_endocrine/exocrine_gland_phen1.46814474
59MP0005377_hearing/vestibular/ear_phenot1.45654699
60MP0003878_abnormal_ear_physiology1.45654699
61MP0002254_reproductive_system_inflammat1.45193506
62MP0006082_CNS_inflammation1.42969686
63MP0002638_abnormal_pupillary_reflex1.42218249
64MP0009697_abnormal_copulation1.39653343
65MP0004381_abnormal_hair_follicle1.39198792
66MP0010094_abnormal_chromosome_stability1.34565719
67MP0003828_pulmonary_edema1.32430433
68MP0005464_abnormal_platelet_physiology1.31811018
69MP0001501_abnormal_sleep_pattern1.30101826
70MP0005174_abnormal_tail_pigmentation1.29904219
71MP0001346_abnormal_lacrimal_gland1.28477030
72MP0005409_darkened_coat_color1.28190953
73MP0000462_abnormal_digestive_system1.25893295
74MP0002006_tumorigenesis1.22349275
75MP0009764_decreased_sensitivity_to1.20551145
76MP0000465_gastrointestinal_hemorrhage1.19509684
77MP0004147_increased_porphyrin_level1.18061146
78MP0002102_abnormal_ear_morphology1.16860876
79MP0002163_abnormal_gland_morphology1.13656451
80MP0002998_abnormal_bone_remodeling1.13114640
81MP0008469_abnormal_protein_level1.11260773
82MP0002166_altered_tumor_susceptibility1.09301122
83MP0002653_abnormal_ependyma_morphology1.09186659
84MP0001986_abnormal_taste_sensitivity1.06288359
85MP0004510_myositis1.03855519
86MP0001851_eye_inflammation1.03154221
87MP0001765_abnormal_ion_homeostasis1.02345332
88MP0000566_synostosis1.02228852
89MP0005390_skeleton_phenotype1.00871324
90MP0003656_abnormal_erythrocyte_physiolo1.00236993
91MP0001502_abnormal_circadian_rhythm0.98042252
92MP0005408_hypopigmentation0.96483412
93MP0001727_abnormal_embryo_implantation0.95921252
94MP0005670_abnormal_white_adipose0.95801412
95MP0001873_stomach_inflammation0.94984161
96MP0003329_amyloid_beta_deposits0.94948282
97MP0000427_abnormal_hair_cycle0.93907649
98MP0003448_altered_tumor_morphology0.93637450
99MP0003937_abnormal_limbs/digits/tail_de0.92841969
100MP0002127_abnormal_cardiovascular_syste0.91942486
101MP0003091_abnormal_cell_migration0.91819666
102MP0000858_altered_metastatic_potential0.91335373
103MP0001881_abnormal_mammary_gland0.90854056
104MP0003252_abnormal_bile_duct0.90721855
105MP0005187_abnormal_penis_morphology0.90021404
106MP0003638_abnormal_response/metabolism_0.88917047
107MP0004130_abnormal_muscle_cell0.88721771
108MP0005381_digestive/alimentary_phenotyp0.87471607
109MP0003191_abnormal_cellular_cholesterol0.87409193
110MP0009763_increased_sensitivity_to0.84596912
111MP0005671_abnormal_response_to0.83657979
112MP0000613_abnormal_salivary_gland0.81002320
113MP0003011_delayed_dark_adaptation0.80252693
114MP0004264_abnormal_extraembryonic_tissu0.80190577
115MP0003566_abnormal_cell_adhesion0.80019895
116MP0001663_abnormal_digestive_system0.79079504
117MP0005310_abnormal_salivary_gland0.78871635
118MP0003195_calcinosis0.78383503
119MP0000249_abnormal_blood_vessel0.78084454
120MP0003183_abnormal_peptide_metabolism0.77928736
121MP0001486_abnormal_startle_reflex0.77124501
122MP0008007_abnormal_cellular_replicative0.75798135
123MP0004885_abnormal_endolymph0.75560136
124MP0001919_abnormal_reproductive_system0.74644948
125MP0002277_abnormal_respiratory_mucosa0.73653061
126MP0001188_hyperpigmentation0.72249569
127MP0002138_abnormal_hepatobiliary_system0.72146774
128MP0000733_abnormal_muscle_development0.72015501
129MP0000639_abnormal_adrenal_gland0.70912163
130MP0002139_abnormal_hepatobiliary_system0.70582609
131MP0005623_abnormal_meninges_morphology0.70213135
132MP0001529_abnormal_vocalization0.67922065
133MP0003795_abnormal_bone_structure0.66145391
134MP0003763_abnormal_thymus_physiology0.65874518
135MP0005083_abnormal_biliary_tract0.65467618
136MP0005000_abnormal_immune_tolerance0.64818792
137MP0003111_abnormal_nucleus_morphology0.64236653
138MP0009765_abnormal_xenobiotic_induced0.64085899
139MP0001800_abnormal_humoral_immune0.63544452
140MP0009278_abnormal_bone_marrow0.63169882
141MP0004742_abnormal_vestibular_system0.61947121
142MP0009840_abnormal_foam_cell0.60039672
143MP0010329_abnormal_lipoprotein_level0.59200551
144MP0000604_amyloidosis0.58076833
145MP0003045_fibrosis0.56970934
146MP0003303_peritoneal_inflammation0.56906542
147MP0008057_abnormal_DNA_replication0.56611107
148MP0005167_abnormal_blood-brain_barrier0.55946608
149MP0002019_abnormal_tumor_incidence0.54596877
150MP0005365_abnormal_bile_salt0.54518434
151MP0001243_abnormal_dermal_layer0.53584895
152MP0004019_abnormal_vitamin_homeostasis0.53578295
153MP0003879_abnormal_hair_cell0.53325615
154MP0005253_abnormal_eye_physiology0.52658207
155MP0000372_irregular_coat_pigmentation0.52344493
156MP0000490_abnormal_crypts_of0.51311111
157MP0005666_abnormal_adipose_tissue0.49830377
158MP0006072_abnormal_retinal_apoptosis0.49580601
159MP0005085_abnormal_gallbladder_physiolo0.49558747
160MP0000609_abnormal_liver_physiology0.46895166
161MP0002136_abnormal_kidney_physiology0.46894012
162MP0002420_abnormal_adaptive_immunity0.46196985
163MP0001819_abnormal_immune_cell0.46092545
164MP0004036_abnormal_muscle_relaxation0.45641290
165MP0002452_abnormal_antigen_presenting0.45552886
166MP0005387_immune_system_phenotype0.45050873
167MP0001790_abnormal_immune_system0.45050873
168MP0002972_abnormal_cardiac_muscle0.44966077
169MP0002723_abnormal_immune_serum0.44056901
170MP0001542_abnormal_bone_strength0.41465235

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.96419409
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.96419409
3T lymphocytopenia (HP:0005403)6.77484145
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.59732605
5Male infertility (HP:0003251)6.58068493
6Abnormality of T cell number (HP:0011839)6.33139845
7IgG deficiency (HP:0004315)6.12675201
8Severe combined immunodeficiency (HP:0004430)5.54581007
9Nasal polyposis (HP:0100582)5.41176289
10Myositis (HP:0100614)5.35460305
11Orchitis (HP:0100796)5.26726375
12Infertility (HP:0000789)5.24790670
13Abnormal respiratory motile cilium physiology (HP:0012261)5.01668326
14Abnormality of eosinophils (HP:0001879)4.93074292
15Abnormal respiratory motile cilium morphology (HP:0005938)4.75803139
16Abnormal respiratory epithelium morphology (HP:0012253)4.75803139
17Abnormality of T cells (HP:0002843)4.74381731
18Rhinitis (HP:0012384)4.64039425
19Abnormal ciliary motility (HP:0012262)4.57773112
20Combined immunodeficiency (HP:0005387)4.37963411
21Elevated erythrocyte sedimentation rate (HP:0003565)4.24213347
22Abnormality of the nasal mucosa (HP:0000433)4.21843426
23Keratoconjunctivitis (HP:0001096)3.85731121
24Keratoconjunctivitis sicca (HP:0001097)3.83618814
25Thyroiditis (HP:0100646)3.80117170
26Stomatitis (HP:0010280)3.79013140
27Cortical dysplasia (HP:0002539)3.69230293
28Stomach cancer (HP:0012126)3.66290196
29Eosinophilia (HP:0001880)3.62340426
30Leukocytosis (HP:0001974)3.62226751
31Pulmonary infiltrates (HP:0002113)3.61859946
32Granulocytopenia (HP:0001913)3.43402246
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.40466318
34Vasculitis (HP:0002633)3.39805347
35Pustule (HP:0200039)3.32844671
36Abnormality of T cell physiology (HP:0011840)3.32725076
37Encephalitis (HP:0002383)3.32066545
38Recurrent fungal infections (HP:0002841)3.31008873
39Hemoptysis (HP:0002105)3.20858056
40Joint swelling (HP:0001386)3.20849551
41Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14815300
42Prostate neoplasm (HP:0100787)3.11790142
43Gastrointestinal infarctions (HP:0005244)3.06418884
44Panhypogammaglobulinemia (HP:0003139)3.04843131
45Papilledema (HP:0001085)3.04453606
46Abnormality of the prostate (HP:0008775)3.04258025
47Gangrene (HP:0100758)2.98672142
48Recurrent cutaneous fungal infections (HP:0011370)2.96054914
49Chronic mucocutaneous candidiasis (HP:0002728)2.96054914
50Facial hemangioma (HP:0000329)2.95339364
51Increased IgM level (HP:0003496)2.95272740
52Bronchiectasis (HP:0002110)2.94124032
53Abnormality of B cell number (HP:0010975)2.92145761
54Anhidrosis (HP:0000970)2.87144136
55Conical tooth (HP:0000698)2.86964006
56Keratitis (HP:0000491)2.85471546
57Focal motor seizures (HP:0011153)2.83528606
58Meningitis (HP:0001287)2.79868683
59Arterial thrombosis (HP:0004420)2.75782108
60Bilateral sensorineural hearing impairment (HP:0008619)2.72296241
61IgM deficiency (HP:0002850)2.71292349
62Anorexia (HP:0002039)2.66362582
63Pulmonary fibrosis (HP:0002206)2.65721175
64Anosmia (HP:0000458)2.65089131
65Pulmonary embolism (HP:0002204)2.64331288
66Chronic bronchitis (HP:0004469)2.63493805
67Abnormality of the pleura (HP:0002103)2.56039286
68Glomerulopathy (HP:0100820)2.55994695
69Chromsome breakage (HP:0040012)2.55801445
70Mediastinal lymphadenopathy (HP:0100721)2.54534143
71Recurrent sinusitis (HP:0011108)2.53707643
72B lymphocytopenia (HP:0010976)2.53194464
73Facial diplegia (HP:0001349)2.50160115
74Renal cortical cysts (HP:0000803)2.42594427
75Neurofibrillary tangles (HP:0002185)2.40944602
76Alveolar cell carcinoma (HP:0006519)2.40362871
77Hemiplegia (HP:0002301)2.40274893
78Growth hormone excess (HP:0000845)2.39716735
79Polyneuropathy (HP:0001271)2.35786515
80Chronic diarrhea (HP:0002028)2.34017755
81Recurrent viral infections (HP:0004429)2.33370201
82Autoimmune thrombocytopenia (HP:0001973)2.28245254
83Abnormality of the labia minora (HP:0012880)2.23308722
84Recurrent otitis media (HP:0000403)2.23023073
85Abnormality of dental color (HP:0011073)2.22252164
86Abnormality of the dental pulp (HP:0006479)2.22204493
87Pancreatitis (HP:0001733)2.22197794
88Persistence of primary teeth (HP:0006335)2.21701705
89Brittle hair (HP:0002299)2.21348437
90Neoplasm of the tracheobronchial system (HP:0100552)2.21230791
91Atonic seizures (HP:0010819)2.20301703
92Abnormality of the pericardium (HP:0001697)2.19391684
93Autoimmune hemolytic anemia (HP:0001890)2.19258926
94Progressive inability to walk (HP:0002505)2.18404490
95Recurrent abscess formation (HP:0002722)2.16383457
96Vertigo (HP:0002321)2.14010317
97Abnormality of male internal genitalia (HP:0000022)2.13410388
98Recurrent bacterial skin infections (HP:0005406)2.09745527
99Agammaglobulinemia (HP:0004432)2.09157127
100Lymphopenia (HP:0001888)2.08899048
101IgA deficiency (HP:0002720)2.08422251
102Hypophosphatemic rickets (HP:0004912)2.08342646
103Abdominal situs inversus (HP:0003363)2.07666303
104Abnormality of abdominal situs (HP:0011620)2.07666303
105Hypoalphalipoproteinemia (HP:0003233)2.05684882
106Hypergammaglobulinemia (HP:0010702)2.04343637
107Gastrointestinal stroma tumor (HP:0100723)2.03955578
108Abnormality of dentin (HP:0010299)2.03861901
109Abnormality of cells of the lymphoid lineage (HP:0012140)2.03599557
110Capillary hemangiomas (HP:0005306)2.03120936
111Recurrent skin infections (HP:0001581)2.02947160
112Hypergonadotropic hypogonadism (HP:0000815)2.02921669
113Short tibia (HP:0005736)2.01546895
114Hypoplasia of the thymus (HP:0000778)2.01350887
115Axonal loss (HP:0003447)2.00434562
116Aortic dissection (HP:0002647)2.00337687
117Bronchitis (HP:0012387)1.99442113
118Abnormality of the endocardium (HP:0004306)1.99250849
119Abnormality of purine metabolism (HP:0004352)1.98233491
120Chest pain (HP:0100749)1.97883495
121Hypoproteinemia (HP:0003075)1.97196043
122Obstructive lung disease (HP:0006536)1.96905423
123Chronic obstructive pulmonary disease (HP:0006510)1.96905423
124Meckel diverticulum (HP:0002245)1.93903641
125Termporal pattern (HP:0011008)1.93640447
126Insidious onset (HP:0003587)1.93640447
127Delayed puberty (HP:0000823)1.92612477
128Hemorrhage of the eye (HP:0011885)1.92393131
129Arthralgia (HP:0002829)1.92155327
130Nephronophthisis (HP:0000090)1.91776405
131Short palpebral fissure (HP:0012745)1.89136691
132Tetany (HP:0001281)1.89014859
133Febrile seizures (HP:0002373)1.88999600
134Acne (HP:0001061)1.87067921
135Vertebral arch anomaly (HP:0008438)1.86272636
136Aplasia/Hypoplasia of the uvula (HP:0010293)1.85904695
137Hypoplasia of the fovea (HP:0007750)1.82920739
138Aplasia/Hypoplasia of the fovea (HP:0008060)1.82920739
139Atrioventricular block (HP:0001678)1.82328350
140Medial flaring of the eyebrow (HP:0010747)1.81644736
141Premature loss of primary teeth (HP:0006323)1.80467735
142Ventricular fibrillation (HP:0001663)1.80174212
143Inflammation of the large intestine (HP:0002037)1.79073256
144Abnormality of macrophages (HP:0004311)1.78742119
145Retrobulbar optic neuritis (HP:0100654)1.78641950
146Optic neuritis (HP:0100653)1.78641950
147Increased density of long bones (HP:0006392)1.78515775
148Hematochezia (HP:0002573)1.77148672
149Abnormality of calcium-phosphate metabolism (HP:0100530)1.76805012
150Dysostosis multiplex (HP:0000943)1.76126605
151Abnormal spermatogenesis (HP:0008669)1.74587754
152Papilloma (HP:0012740)1.74586085
153Verrucae (HP:0200043)1.74586085
154Increased IgE level (HP:0003212)1.74485006
155Progressive microcephaly (HP:0000253)1.74031467
156Myotonia (HP:0002486)1.73640269
157Neutropenia (HP:0001875)1.73476080
158Abolished electroretinogram (ERG) (HP:0000550)1.72564851
159Long toe (HP:0010511)1.72382754
160Abnormality of the ileum (HP:0001549)1.71922209
161Heart block (HP:0012722)1.69490407
162Disinhibition (HP:0000734)1.68563075
163Petechiae (HP:0000967)1.67960650
164Trigonocephaly (HP:0000243)1.66388472
165Clubbing of toes (HP:0100760)1.66349215
166Azoospermia (HP:0000027)1.64885587
167Eczematoid dermatitis (HP:0000976)1.64691203
168Abnormal atrioventricular conduction (HP:0005150)1.64604803
169Diplopia (HP:0000651)1.64216262
170Abnormality of binocular vision (HP:0011514)1.64216262
171Thickened helices (HP:0000391)1.63413730
172Heterotopia (HP:0002282)1.63232072
173Primary amenorrhea (HP:0000786)1.62801207
174Abnormality of the preputium (HP:0100587)1.62585178
175Cellulitis (HP:0100658)1.61287300
176Insulin-resistant diabetes mellitus (HP:0000831)1.59138433
177Bundle branch block (HP:0011710)1.57684266
178Aplasia/Hypoplasia of the tibia (HP:0005772)1.56885696
179Adrenal hypoplasia (HP:0000835)1.56839276
180Recurrent bronchitis (HP:0002837)1.56740985
181Abnormality of chromosome segregation (HP:0002916)1.56274411
182Clitoromegaly (HP:0000057)1.54975324
183Abnormality of the fovea (HP:0000493)1.54634034
184Clumsiness (HP:0002312)1.54375641
185Bifid tongue (HP:0010297)1.53939696
186Wide intermamillary distance (HP:0006610)1.53555931
187Skull defect (HP:0001362)1.53380360
188Absence seizures (HP:0002121)1.52795152
189Midline defect of the nose (HP:0004122)1.52622674
190Chronic sinusitis (HP:0011109)1.50647633
191Abnormality of the carotid arteries (HP:0005344)1.50416375
192Secondary amenorrhea (HP:0000869)1.48289666
193Atelectasis (HP:0100750)1.48040882

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L6.93371715
2MAP3K143.62737302
3MAP2K23.57808942
4LATS23.55642676
5MAP4K13.41472903
6PDK43.28743469
7PDK33.28743469
8ERBB43.18914550
9PRKD32.99763656
10SCYL22.92463124
11LATS12.83040453
12KSR22.72130539
13BCR2.61049260
14TESK22.58673872
15FES2.57314703
16STK382.50670088
17IKBKE2.48375610
18CDK92.41163646
19IKBKB2.36821700
20STK32.24982324
21MAP3K62.16175281
22TBK12.13785702
23MATK2.06802254
24STK242.01878710
25TLK11.96988028
26PAK61.87224826
27ZAP701.87100780
28PDK21.85612780
29BMPR21.79863691
30PIK3CG1.64598921
31KIT1.63016817
32TAOK31.59866294
33KDR1.56025490
34SYK1.52177869
35EPHA41.52162729
36JAK31.48473260
37LCK1.47608943
38IRAK41.45001740
39DYRK21.42853812
40CHEK21.41633673
41IRAK31.36143557
42CSK1.34716469
43TRPM71.33941370
44CDK31.33839607
45MAP3K41.30740045
46EPHA31.28797335
47NLK1.28474232
48BTK1.25487347
49PRKCQ1.22623445
50RIPK41.22240043
51ZAK1.18285550
52LYN1.14403313
53HIPK21.14130517
54MARK31.12748794
55STK391.11083041
56HCK1.04250390
57MAPK71.02793952
58NEK21.00110866
59ADRBK21.00024845
60MAP2K70.99729621
61LMTK20.99729270
62MYLK0.98310860
63MAP4K20.95787044
64TESK10.94927974
65CSF1R0.94687160
66BCKDK0.94182630
67EPHB10.92016949
68MST40.90347813
69MAP3K20.89976886
70TEC0.89004009
71PHKG20.88635625
72PHKG10.88635625
73ABL20.87059487
74STK100.86947241
75CDK40.85713163
76JAK10.84917356
77TXK0.84772354
78CHUK0.84496797
79BLK0.84056200
80NEK60.83996967
81EIF2AK20.83430316
82GRK70.81988354
83SIK30.76382999
84MAP2K40.73997856
85CAMKK20.71643135
86CSNK1G10.71456891
87TNK20.70246923
88MAP2K60.70158247
89MAPKAPK30.68470612
90RAF10.68461314
91TAOK10.68324158
92PRKCH0.67549921
93CDK60.64575346
94WNK40.64535125
95PKN10.64115839
96PRKD20.62264591
97CDK80.59985459
98KSR10.58065186
99MAP3K90.57237541
100FGR0.55661757
101RPS6KA20.55045111
102PRKAA10.54646928
103TTK0.54061269
104MST1R0.53473930
105MAPK40.50386844
106IGF1R0.50046789
107DDR20.49674691
108FYN0.49199932
109MAPK150.47982196
110TYRO30.47792518
111MARK10.47289257
112MAP3K100.46348035
113NTRK10.46131413
114NUAK10.45969382
115PAK20.45808824
116CAMK2G0.45405938
117ABL10.45218585
118RPS6KA60.44863136
119MAPKAPK20.44347297
120GRK60.44102203
121EEF2K0.43082058
122DYRK1B0.42968943
123MUSK0.42176062
124RET0.40980882
125ARAF0.40685747
126CSNK1G20.40483518
127MELK0.40298601
128ALK0.40241689
129PAK30.40173527
130IRAK20.40136503
131MAPKAPK50.39957295
132INSR0.39686584
133MAPK30.39560108
134RPS6KL10.39286079
135RPS6KC10.39286079
136DYRK1A0.38986735
137MOS0.37876246
138MAPK110.37726916
139PINK10.36776709
140GRK10.36163154
141FGFR40.36073316
142JAK20.35656806
143MAP3K70.35484553
144MAPK120.34640163
145CAMK2A0.34589097
146CDC70.32807009
147MAPK130.32397111
148TGFBR20.31388148
149NTRK20.30435590
150CDK120.29693835
151ERBB30.29007571
152OXSR10.28936992
153IRAK10.28928332
154PIK3CA0.28769078
155PRKAA20.28279950
156CSNK1G30.27949062
157PRKCD0.27237243
158PIM10.27090028
159ITK0.26784702
160PDK10.26350095
161RPS6KA10.26006917
162GSK3A0.25533416
163MAP2K10.24685517
164MAP3K80.24557623
165GRK50.23221478
166MAP3K130.23156361
167TYK20.23067387
168CSNK1A1L0.21942589
169PRKD10.19979870
170ADRBK10.18977285
171CAMKK10.17514943

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.73146321
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.79483991
3Dorso-ventral axis formation_Homo sapiens_hsa043202.72287709
4Basal transcription factors_Homo sapiens_hsa030222.61492429
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55660143
6Vitamin B6 metabolism_Homo sapiens_hsa007502.47146037
7Non-homologous end-joining_Homo sapiens_hsa034502.39924644
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.33763085
9Allograft rejection_Homo sapiens_hsa053302.31048464
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.30753065
11Autoimmune thyroid disease_Homo sapiens_hsa053202.27367256
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.25383104
13Antigen processing and presentation_Homo sapiens_hsa046122.23919446
14Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.17862133
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.15316431
16Ovarian steroidogenesis_Homo sapiens_hsa049131.97458852
17Leishmaniasis_Homo sapiens_hsa051401.97004707
18Measles_Homo sapiens_hsa051621.96602692
19Osteoclast differentiation_Homo sapiens_hsa043801.94253770
20Sphingolipid metabolism_Homo sapiens_hsa006001.88217209
21Hematopoietic cell lineage_Homo sapiens_hsa046401.85718423
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.85716930
23Mineral absorption_Homo sapiens_hsa049781.76720077
24TNF signaling pathway_Homo sapiens_hsa046681.75610096
25GnRH signaling pathway_Homo sapiens_hsa049121.73826823
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63210421
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60161802
28Pancreatic cancer_Homo sapiens_hsa052121.59053704
29Type I diabetes mellitus_Homo sapiens_hsa049401.56927767
30Fanconi anemia pathway_Homo sapiens_hsa034601.52011000
31beta-Alanine metabolism_Homo sapiens_hsa004101.51778824
32Graft-versus-host disease_Homo sapiens_hsa053321.50911967
33Linoleic acid metabolism_Homo sapiens_hsa005911.49327238
34Arginine and proline metabolism_Homo sapiens_hsa003301.47827877
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46838783
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.45996399
37Herpes simplex infection_Homo sapiens_hsa051681.45854825
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42682746
39Chemokine signaling pathway_Homo sapiens_hsa040621.41829050
40Bladder cancer_Homo sapiens_hsa052191.41050353
41Ether lipid metabolism_Homo sapiens_hsa005651.40717144
42Histidine metabolism_Homo sapiens_hsa003401.39643078
43Sulfur relay system_Homo sapiens_hsa041221.37035550
44Acute myeloid leukemia_Homo sapiens_hsa052211.36182644
45Fatty acid metabolism_Homo sapiens_hsa012121.35570756
46Fatty acid degradation_Homo sapiens_hsa000711.32213587
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31072810
48Rheumatoid arthritis_Homo sapiens_hsa053231.30794165
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.25550766
50Pentose phosphate pathway_Homo sapiens_hsa000301.23432250
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21802704
52Legionellosis_Homo sapiens_hsa051341.19670698
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.17554288
54Apoptosis_Homo sapiens_hsa042101.16805516
55Propanoate metabolism_Homo sapiens_hsa006401.15580784
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15507367
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14465552
58Oocyte meiosis_Homo sapiens_hsa041141.13984355
59Glycerophospholipid metabolism_Homo sapiens_hsa005641.13349681
60VEGF signaling pathway_Homo sapiens_hsa043701.12592001
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10773927
62Choline metabolism in cancer_Homo sapiens_hsa052311.10613425
63Inositol phosphate metabolism_Homo sapiens_hsa005621.08941280
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08692986
65Circadian rhythm_Homo sapiens_hsa047101.05863708
66Glycerolipid metabolism_Homo sapiens_hsa005611.04500392
67Folate biosynthesis_Homo sapiens_hsa007901.03429954
68PPAR signaling pathway_Homo sapiens_hsa033201.01373209
69Asthma_Homo sapiens_hsa053101.00385736
70Shigellosis_Homo sapiens_hsa051310.99819760
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96598965
72Estrogen signaling pathway_Homo sapiens_hsa049150.94907138
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.94032895
74B cell receptor signaling pathway_Homo sapiens_hsa046620.91880865
75Renal cell carcinoma_Homo sapiens_hsa052110.91771032
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89689815
77Regulation of autophagy_Homo sapiens_hsa041400.88777504
78Phototransduction_Homo sapiens_hsa047440.87834554
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86606263
80Toxoplasmosis_Homo sapiens_hsa051450.86311710
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85439995
82Purine metabolism_Homo sapiens_hsa002300.85111674
83Glioma_Homo sapiens_hsa052140.83296207
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83036538
85Arachidonic acid metabolism_Homo sapiens_hsa005900.82188489
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81151849
87Tuberculosis_Homo sapiens_hsa051520.79434498
88Staphylococcus aureus infection_Homo sapiens_hsa051500.79303713
89Pertussis_Homo sapiens_hsa051330.78721661
90ErbB signaling pathway_Homo sapiens_hsa040120.78388051
91Morphine addiction_Homo sapiens_hsa050320.78274731
92Primary immunodeficiency_Homo sapiens_hsa053400.77140173
93Non-small cell lung cancer_Homo sapiens_hsa052230.77084224
94Nitrogen metabolism_Homo sapiens_hsa009100.76575741
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73803639
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73321857
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.73005487
98Hepatitis B_Homo sapiens_hsa051610.72044723
99Pyruvate metabolism_Homo sapiens_hsa006200.71674811
100Hepatitis C_Homo sapiens_hsa051600.69263256
101Gastric acid secretion_Homo sapiens_hsa049710.68744805
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68310223
103Tight junction_Homo sapiens_hsa045300.67969238
104Long-term potentiation_Homo sapiens_hsa047200.66887970
105cAMP signaling pathway_Homo sapiens_hsa040240.66093248
106Influenza A_Homo sapiens_hsa051640.65766496
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65199308
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.63060987
109Starch and sucrose metabolism_Homo sapiens_hsa005000.62500467
110* Malaria_Homo sapiens_hsa051440.61997981
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60322432
112Prolactin signaling pathway_Homo sapiens_hsa049170.60315597
113Chronic myeloid leukemia_Homo sapiens_hsa052200.59129677
114Melanoma_Homo sapiens_hsa052180.58677028
115RNA degradation_Homo sapiens_hsa030180.58066209
116African trypanosomiasis_Homo sapiens_hsa051430.57194559
117Renin secretion_Homo sapiens_hsa049240.56911102
118Endocytosis_Homo sapiens_hsa041440.56002036
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55814251
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54824057
121Glucagon signaling pathway_Homo sapiens_hsa049220.54138354
122Bile secretion_Homo sapiens_hsa049760.53426297
123Epstein-Barr virus infection_Homo sapiens_hsa051690.53133768
124Viral carcinogenesis_Homo sapiens_hsa052030.52940399
125Salivary secretion_Homo sapiens_hsa049700.51944878
126Platelet activation_Homo sapiens_hsa046110.50264700
127Long-term depression_Homo sapiens_hsa047300.49645906
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48534177
129T cell receptor signaling pathway_Homo sapiens_hsa046600.47977698
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47699868
131Ras signaling pathway_Homo sapiens_hsa040140.47068650
132Rap1 signaling pathway_Homo sapiens_hsa040150.46895326
133mTOR signaling pathway_Homo sapiens_hsa041500.44395048
134Colorectal cancer_Homo sapiens_hsa052100.43914003
135HTLV-I infection_Homo sapiens_hsa051660.43833656
136Glutamatergic synapse_Homo sapiens_hsa047240.43549255
137Prostate cancer_Homo sapiens_hsa052150.42846909
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.42103954
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41782141
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40899300
141Viral myocarditis_Homo sapiens_hsa054160.39930661
142Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39856085
143MicroRNAs in cancer_Homo sapiens_hsa052060.39475190
144Other glycan degradation_Homo sapiens_hsa005110.39167417
145Cell cycle_Homo sapiens_hsa041100.38897437
146MAPK signaling pathway_Homo sapiens_hsa040100.38013810
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37861597
148Lysosome_Homo sapiens_hsa041420.36492712
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36221478
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34922400
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33637024
152Salmonella infection_Homo sapiens_hsa051320.33421578
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29253903
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.28322092
155Insulin resistance_Homo sapiens_hsa049310.28228266
156Caffeine metabolism_Homo sapiens_hsa002320.26912145
157Fat digestion and absorption_Homo sapiens_hsa049750.21807012
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.21411985
159Olfactory transduction_Homo sapiens_hsa047400.16790369
160ABC transporters_Homo sapiens_hsa020100.16685245
161FoxO signaling pathway_Homo sapiens_hsa040680.16093134
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.15766194
163Retinol metabolism_Homo sapiens_hsa008300.14528703
164Taste transduction_Homo sapiens_hsa047420.14055735

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