KLRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)8.59912607
2negative T cell selection (GO:0043383)8.41243934
3regulation of isotype switching to IgG isotypes (GO:0048302)8.38409175
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.26915869
5negative regulation of cell killing (GO:0031342)8.26915869
6negative thymic T cell selection (GO:0045060)7.81539256
7T cell migration (GO:0072678)7.73706505
8regulation of natural killer cell mediated cytotoxicity (GO:0042269)7.69733889
9regulation of natural killer cell mediated immunity (GO:0002715)7.69733889
10positive regulation of gamma-delta T cell activation (GO:0046645)7.64526989
11positive regulation of natural killer cell mediated immunity (GO:0002717)7.40664041
12positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)7.40664041
13cytidine metabolic process (GO:0046087)7.34980336
14cytidine catabolic process (GO:0006216)7.34980336
15cytidine deamination (GO:0009972)7.34980336
16cellular response to interleukin-15 (GO:0071350)6.93403050
17activated T cell proliferation (GO:0050798)6.84031037
18regulation of memory T cell differentiation (GO:0043380)6.81345303
19pyrimidine ribonucleoside catabolic process (GO:0046133)6.77314790
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.76181885
21positive thymic T cell selection (GO:0045059)6.71578005
22DNA deamination (GO:0045006)6.55140359
23positive T cell selection (GO:0043368)6.47620790
24thymic T cell selection (GO:0045061)6.24186690
25response to interleukin-15 (GO:0070672)6.21514033
26regulation of gamma-delta T cell differentiation (GO:0045586)6.02921671
27positive regulation of isotype switching (GO:0045830)5.94165277
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.64256151
29regulation of leukocyte mediated cytotoxicity (GO:0001910)5.56181865
30positive regulation of defense response to virus by host (GO:0002230)5.53021553
31positive regulation of cell killing (GO:0031343)5.52087790
32positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.47450122
33regulation of B cell receptor signaling pathway (GO:0050855)5.45493587
34regulation of cell killing (GO:0031341)5.43586760
35T cell selection (GO:0045058)5.42605032
36regulation of gamma-delta T cell activation (GO:0046643)5.37696895
37cytolysis (GO:0019835)5.35429972
38positive regulation of immunoglobulin mediated immune response (GO:0002891)5.29942066
39positive regulation of B cell mediated immunity (GO:0002714)5.29942066
40positive regulation of DNA recombination (GO:0045911)5.25723394
41leukocyte aggregation (GO:0070486)5.21897577
42positive regulation of immune response to tumor cell (GO:0002839)5.16257218
43regulation of immune response to tumor cell (GO:0002837)5.16257218
44regulation of response to tumor cell (GO:0002834)5.16257218
45positive regulation of response to tumor cell (GO:0002836)5.16257218
46cellular defense response (GO:0006968)5.07396704
47regulation of T cell tolerance induction (GO:0002664)5.02792975
48positive regulation of T cell mediated cytotoxicity (GO:0001916)5.02747052
49T cell costimulation (GO:0031295)5.02362574
50T cell receptor signaling pathway (GO:0050852)4.99968897
51positive regulation of alpha-beta T cell proliferation (GO:0046641)4.95097252
52positive regulation of T cell cytokine production (GO:0002726)4.93869933
53lymphocyte costimulation (GO:0031294)4.91813924
54lymphocyte migration (GO:0072676)4.85260001
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.81636265
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.78312068
57regulation of alpha-beta T cell proliferation (GO:0046640)4.66331379
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61775001
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61775001
60sequestering of actin monomers (GO:0042989)4.58078434
61negative regulation of T cell mediated immunity (GO:0002710)4.47705021
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.46737917
63regulation of isotype switching (GO:0045191)4.38284634
64positive regulation of T cell chemotaxis (GO:0010820)4.37906594
65regulation of T cell chemotaxis (GO:0010819)4.37906594
66regulation of immunoglobulin mediated immune response (GO:0002889)4.34894091
67heterotypic cell-cell adhesion (GO:0034113)4.33228541
68antigen receptor-mediated signaling pathway (GO:0050851)4.21635841
69regulation of B cell mediated immunity (GO:0002712)4.18904629
70regulation of T-helper 1 type immune response (GO:0002825)4.17041064
71positive regulation of T-helper 1 type immune response (GO:0002827)4.16742951
72leukocyte cell-cell adhesion (GO:0007159)4.14681641
73natural killer cell activation (GO:0030101)4.14651707
74negative regulation of T-helper cell differentiation (GO:0045623)4.13704015
75negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.13704015
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.08326112
77positive regulation of lymphocyte mediated immunity (GO:0002708)4.06031040
78regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.05542803
79regulation of T cell receptor signaling pathway (GO:0050856)4.04696035
80positive regulation of tolerance induction (GO:0002645)4.03890864
81positive regulation of T cell mediated immunity (GO:0002711)4.03027861
82regulation of response to interferon-gamma (GO:0060330)4.00697652
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.98668688
84T cell differentiation involved in immune response (GO:0002292)3.98030356
85alpha-beta T cell differentiation involved in immune response (GO:0002293)3.98030356
86alpha-beta T cell activation involved in immune response (GO:0002287)3.98030356
87negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.95758853
88mast cell activation (GO:0045576)3.90262079
89positive regulation of immunoglobulin production (GO:0002639)3.88565126
90regulation of lymphocyte mediated immunity (GO:0002706)3.85785542
91regulation of interleukin-12 biosynthetic process (GO:0045075)3.85410360
92negative regulation of alpha-beta T cell activation (GO:0046636)3.79593805
93antigen processing and presentation of endogenous antigen (GO:0019883)3.75136485
94regulation of defense response to virus by host (GO:0050691)3.67538447
95regulation of T cell mediated immunity (GO:0002709)3.66624633
96T cell differentiation (GO:0030217)3.65076073
97negative regulation of lymphocyte mediated immunity (GO:0002707)3.62853703
98regulation of lymphocyte chemotaxis (GO:1901623)3.61453856
99negative regulation of leukocyte mediated immunity (GO:0002704)3.57194069
100regulation of tolerance induction (GO:0002643)3.52801904
101negative regulation of DNA-templated transcription, elongation (GO:0032785)3.48139936
102alpha-beta T cell differentiation (GO:0046632)3.46984621
103alpha-beta T cell activation (GO:0046631)3.46170763
104positive regulation of leukocyte mediated immunity (GO:0002705)3.45844772
105T cell activation (GO:0042110)3.44561253
106positive regulation of humoral immune response (GO:0002922)3.43467737
107protein polyglutamylation (GO:0018095)3.41484826
108negative regulation of T cell receptor signaling pathway (GO:0050860)3.38856770
109negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.38161196
110pyrimidine nucleoside catabolic process (GO:0046135)3.37456345
111adaptation of signaling pathway (GO:0023058)3.35415974
112negative regulation by host of viral transcription (GO:0043922)3.34848265
113mast cell activation involved in immune response (GO:0002279)3.32693128
114mast cell degranulation (GO:0043303)3.32693128
115regulation of B cell differentiation (GO:0045577)3.32614456
116negative regulation of alpha-beta T cell differentiation (GO:0046639)3.32591269
117positive regulation of interleukin-17 production (GO:0032740)3.29187629
118T cell activation involved in immune response (GO:0002286)3.28621539
119lymphocyte chemotaxis (GO:0048247)3.28290090
120negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.27564923
121regulation of T cell cytokine production (GO:0002724)3.27387339
122positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.20935006
123leukocyte degranulation (GO:0043299)3.19300763
124positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.17868642
125T cell proliferation (GO:0042098)3.16682316
126sleep (GO:0030431)3.14620789
127negative regulation of adaptive immune response (GO:0002820)3.14312123
128regulation of chemokine-mediated signaling pathway (GO:0070099)3.13905875
129regulation of immunoglobulin production (GO:0002637)3.12987026
130regulation of T cell mediated cytotoxicity (GO:0001914)3.11711277
131signal complex assembly (GO:0007172)3.10838220
132positive regulation of T cell activation (GO:0050870)3.10394037
133regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.09695763
134regulation of activation of Janus kinase activity (GO:0010533)3.09045853
135positive regulation of interferon-gamma production (GO:0032729)3.09032298
136B cell receptor signaling pathway (GO:0050853)3.08614247
137positive regulation of T cell differentiation in thymus (GO:0033089)3.08372430
138positive regulation of lamellipodium assembly (GO:0010592)3.07164145
139regulation of regulatory T cell differentiation (GO:0045589)3.06745325
140antigen processing and presentation via MHC class Ib (GO:0002475)3.06693866
141negative regulation of viral genome replication (GO:0045071)3.01486529
142positive regulation of calcium-mediated signaling (GO:0050850)3.00861720
143positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.00708992
144negative regulation of T cell apoptotic process (GO:0070233)3.00649650
145regulation of natural killer cell activation (GO:0032814)2.99605819
146negative regulation of mast cell activation (GO:0033004)2.96132377
147regulation of T-helper cell differentiation (GO:0045622)2.92924900
148regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.90880621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.18770922
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.55385885
3* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.60856396
4* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.44899944
5RUNX_20019798_ChIP-Seq_JUKART_Human4.26614680
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.15561743
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.09323612
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.88189142
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76659728
10MYB_26560356_Chip-Seq_TH2_Human3.45175139
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24650225
12MAF_26560356_Chip-Seq_TH1_Human3.00311538
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.84570958
14E2F7_22180533_ChIP-Seq_HELA_Human2.83724829
15MYB_26560356_Chip-Seq_TH1_Human2.81881106
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.66689267
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65622820
18UTX_26944678_Chip-Seq_JUKART_Human2.65462608
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.57431350
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41613948
21MYC_22102868_ChIP-Seq_BL_Human2.27771708
22GATA3_27048872_Chip-Seq_THYMUS_Human2.23518296
23SPI1_23547873_ChIP-Seq_NB4_Human2.07236779
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.05742136
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.04786163
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02604359
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.98884548
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97044250
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95686787
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93500209
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89468171
32MAF_26560356_Chip-Seq_TH2_Human1.86551379
33VDR_22108803_ChIP-Seq_LS180_Human1.83380083
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81069457
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.81052645
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80072756
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.75987031
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70451846
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64739021
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61890062
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.61274033
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59984136
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58538826
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55667193
45VDR_21846776_ChIP-Seq_THP-1_Human1.55604696
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53332383
47ZNF274_21170338_ChIP-Seq_K562_Hela1.50786842
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50722944
49GATA3_26560356_Chip-Seq_TH2_Human1.45638477
50SCL_19346495_ChIP-Seq_HPC-7_Human1.44310251
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44039161
52TCF7_22412390_ChIP-Seq_EML_Mouse1.42473954
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38564205
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.37957846
55GATA1_22025678_ChIP-Seq_K562_Human1.36223505
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36108315
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32404039
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.29823178
59VDR_24763502_ChIP-Seq_THP-1_Human1.29033241
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28591178
61* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27433165
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27281319
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27275749
64TP53_22573176_ChIP-Seq_HFKS_Human1.26376785
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26148523
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26005216
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24383859
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22413346
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20534674
70SPI1_23127762_ChIP-Seq_K562_Human1.19217545
71* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18160150
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.17297412
73VDR_23849224_ChIP-Seq_CD4+_Human1.15457344
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14961884
75* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14383983
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12918932
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10736376
78ER_23166858_ChIP-Seq_MCF-7_Human1.10118751
79PU_27001747_Chip-Seq_BMDM_Mouse1.07065498
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07034594
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.07034594
82* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06390945
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06364851
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05883870
85GATA3_26560356_Chip-Seq_TH1_Human1.05344199
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05343133
87MYC_18940864_ChIP-ChIP_HL60_Human1.04787922
88KDM2B_26808549_Chip-Seq_DND41_Human1.04711230
89CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03643326
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02327081
91* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00887325
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00529665
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00495469
94AR_20517297_ChIP-Seq_VCAP_Human0.98997727
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97836360
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97326347
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.96784968
98FLI1_21867929_ChIP-Seq_CD8_Mouse0.96381397
99SMRT_27268052_Chip-Seq_Bcells_Human0.96139197
100HOXB7_26014856_ChIP-Seq_BT474_Human0.95868762
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95493947
102PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95212491
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95067921
104HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94503008
105CRX_20693478_ChIP-Seq_RETINA_Mouse0.94100173
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93626082
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93614591
108ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93191226
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93051604
110CBP_20019798_ChIP-Seq_JUKART_Human0.93051604
111TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92201985
112FOXH1_21741376_ChIP-Seq_EPCs_Human0.91337617
113BCAT_22108803_ChIP-Seq_LS180_Human0.91236363
114BCL6_27268052_Chip-Seq_Bcells_Human0.91028140
115ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90632804
116* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90556834
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90233966
118* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89553688
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.88921531
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88560818
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88187850
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86774686
123TAF15_26573619_Chip-Seq_HEK293_Human0.85649141
124FOXP3_21729870_ChIP-Seq_TREG_Human0.84385135
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84107678
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83445203
127NANOG_20526341_ChIP-Seq_ESCs_Human0.83416390
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83004346
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79768118
130VDR_24787735_ChIP-Seq_THP-1_Human0.79409750
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78032793
132EGR1_19032775_ChIP-ChIP_M12_Human0.77766136
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77349941
134KDM2B_26808549_Chip-Seq_JURKAT_Human0.75822192
135RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75449576
136ELK3_25401928_ChIP-Seq_HUVEC_Human0.75112044
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.75075441
138SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.72786907
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71155977
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69806975
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69514862
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65824336
143EGR1_19374776_ChIP-ChIP_THP-1_Human0.64333190
144GATA1_19941827_ChIP-Seq_MEL_Mouse0.63829464
145SPI1_20517297_ChIP-Seq_HL60_Human0.63591615
146GATA2_19941826_ChIP-Seq_K562_Human0.63290592
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61839539
148ELK1_19687146_ChIP-ChIP_HELA_Human0.60773225
149IRF1_19129219_ChIP-ChIP_H3396_Human0.60554756
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60552514
151E2F4_17652178_ChIP-ChIP_JURKAT_Human0.58916158
152CIITA_25753668_ChIP-Seq_RAJI_Human0.58627940
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.58359712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.99422603
2MP0003763_abnormal_thymus_physiology5.23194546
3MP0006082_CNS_inflammation4.80571682
4MP0009785_altered_susceptibility_to4.00052267
5MP0001986_abnormal_taste_sensitivity3.36858725
6MP0001800_abnormal_humoral_immune3.19897110
7MP0002420_abnormal_adaptive_immunity3.10270884
8MP0009333_abnormal_splenocyte_physiolog3.07341903
9MP0001819_abnormal_immune_cell3.04642386
10MP0001873_stomach_inflammation2.98820573
11MP0005000_abnormal_immune_tolerance2.95313186
12MP0005025_abnormal_response_to2.94270035
13MP0003448_altered_tumor_morphology2.93182143
14MP0001835_abnormal_antigen_presentation2.90593111
15MP0002723_abnormal_immune_serum2.88625858
16MP0000685_abnormal_immune_system2.79056279
17MP0002398_abnormal_bone_marrow2.76910343
18MP0000858_altered_metastatic_potential2.70428626
19MP0005387_immune_system_phenotype2.59272499
20MP0001790_abnormal_immune_system2.59272499
21MP0002405_respiratory_system_inflammati2.56071403
22MP0002452_abnormal_antigen_presenting2.54339543
23MP0000703_abnormal_thymus_morphology2.50005093
24MP0002166_altered_tumor_susceptibility2.46828573
25MP0002006_tumorigenesis2.44786904
26MP0000716_abnormal_immune_system2.43292665
27MP0002722_abnormal_immune_system2.26904534
28MP0003724_increased_susceptibility_to2.24984923
29MP0000689_abnormal_spleen_morphology2.13047577
30MP0002148_abnormal_hypersensitivity_rea2.11019503
31MP0002933_joint_inflammation2.10068240
32MP0000569_abnormal_digit_pigmentation2.07904361
33MP0003045_fibrosis2.02394739
34MP0002132_abnormal_respiratory_system1.98200085
35MP0003195_calcinosis1.96806995
36MP0004947_skin_inflammation1.96576377
37MP0002429_abnormal_blood_cell1.94131960
38MP0010155_abnormal_intestine_physiology1.90002977
39MP0002419_abnormal_innate_immunity1.86889627
40MP0004147_increased_porphyrin_level1.85749066
41MP0003436_decreased_susceptibility_to1.85727817
42MP0002009_preneoplasia1.77689538
43MP0001845_abnormal_inflammatory_respons1.73087651
44MP0005464_abnormal_platelet_physiology1.72651757
45MP0003866_abnormal_defecation1.49823407
46MP0002876_abnormal_thyroid_physiology1.44067575
47MP0005174_abnormal_tail_pigmentation1.41880415
48MP0002019_abnormal_tumor_incidence1.36742550
49MP0005423_abnormal_somatic_nervous1.32895058
50MP0008469_abnormal_protein_level1.28277219
51MP0005166_decreased_susceptibility_to1.28235244
52MP0001851_eye_inflammation1.24326654
53MP0008877_abnormal_DNA_methylation1.23175049
54MP0004381_abnormal_hair_follicle1.21931716
55MP0003011_delayed_dark_adaptation1.20867521
56MP0002102_abnormal_ear_morphology1.19882501
57MP0002163_abnormal_gland_morphology1.17101208
58MP0000015_abnormal_ear_pigmentation1.13310491
59MP0004043_abnormal_pH_regulation1.12054464
60MP0001501_abnormal_sleep_pattern1.11158484
61MP0010307_abnormal_tumor_latency1.10565736
62MP0006054_spinal_hemorrhage1.10001483
63MP0002396_abnormal_hematopoietic_system1.09775832
64MP0002998_abnormal_bone_remodeling1.08120013
65MP0003950_abnormal_plasma_membrane1.05813764
66MP0002138_abnormal_hepatobiliary_system1.05255412
67MP0001533_abnormal_skeleton_physiology1.02970361
68MP0009763_increased_sensitivity_to1.01303371
69MP0000490_abnormal_crypts_of0.97898240
70MP0003252_abnormal_bile_duct0.94215548
71MP0006072_abnormal_retinal_apoptosis0.93503174
72MP0008872_abnormal_physiological_respon0.90439463
73MP0000372_irregular_coat_pigmentation0.90159315
74MP0003300_gastrointestinal_ulcer0.87948743
75MP0001765_abnormal_ion_homeostasis0.85308545
76MP0000920_abnormal_myelination0.82978827
77MP0001243_abnormal_dermal_layer0.81820470
78MP0001984_abnormal_olfaction0.79087381
79MP0003878_abnormal_ear_physiology0.78895516
80MP0005377_hearing/vestibular/ear_phenot0.78895516
81MP0002136_abnormal_kidney_physiology0.77183860
82MP0001968_abnormal_touch/_nociception0.74972312
83MP0001188_hyperpigmentation0.74437077
84MP0002736_abnormal_nociception_after0.73698574
85MP0005310_abnormal_salivary_gland0.73076874
86MP0003693_abnormal_embryo_hatching0.72721320
87MP0003183_abnormal_peptide_metabolism0.72276430
88MP0010352_gastrointestinal_tract_polyps0.71751560
89MP0005551_abnormal_eye_electrophysiolog0.69362735
90MP0005075_abnormal_melanosome_morpholog0.69301212
91MP0000371_diluted_coat_color0.68477096
92MP0005253_abnormal_eye_physiology0.68392094
93MP0005390_skeleton_phenotype0.67816477
94MP0005645_abnormal_hypothalamus_physiol0.67288136
95MP0002095_abnormal_skin_pigmentation0.66954529
96MP0004957_abnormal_blastocyst_morpholog0.66783539
97MP0008875_abnormal_xenobiotic_pharmacok0.66763358
98MP0000465_gastrointestinal_hemorrhage0.65924437
99MP0002822_catalepsy0.65507974
100MP0003806_abnormal_nucleotide_metabolis0.65467082
101MP0000613_abnormal_salivary_gland0.64656367
102MP0002653_abnormal_ependyma_morphology0.62859273
103MP0004142_abnormal_muscle_tone0.62717541
104MP0009765_abnormal_xenobiotic_induced0.62232088
105MP0001348_abnormal_lacrimal_gland0.61409644
106MP0010234_abnormal_vibrissa_follicle0.60240971
107MP0009643_abnormal_urine_homeostasis0.60115594
108MP0004808_abnormal_hematopoietic_stem0.60105046
109MP0001919_abnormal_reproductive_system0.59882936
110MP0004885_abnormal_endolymph0.59751757
111MP0004145_abnormal_muscle_electrophysio0.59632773
112MP0000609_abnormal_liver_physiology0.59115357
113MP0005379_endocrine/exocrine_gland_phen0.59021710
114MP0009764_decreased_sensitivity_to0.58042807
115MP0005167_abnormal_blood-brain_barrier0.57248169
116MP0001191_abnormal_skin_condition0.54419103
117MP0003656_abnormal_erythrocyte_physiolo0.54182478
118MP0008873_increased_physiological_sensi0.54012359
119MP0002168_other_aberrant_phenotype0.50668103
120MP0000343_altered_response_to0.48424895
121MP0008057_abnormal_DNA_replication0.47986660
122MP0002693_abnormal_pancreas_physiology0.47870329
123MP0001881_abnormal_mammary_gland0.46445912
124MP0008058_abnormal_DNA_repair0.45499695
125MP0003795_abnormal_bone_structure0.45392773
126MP0005584_abnormal_enzyme/coenzyme_acti0.44415899
127MP0001853_heart_inflammation0.43792419
128MP0003279_aneurysm0.42764748
129MP0005023_abnormal_wound_healing0.42753228
130MP0005451_abnormal_body_composition0.41350765
131MP0000477_abnormal_intestine_morphology0.41274683
132MP0001216_abnormal_epidermal_layer0.40365481
133MP0003566_abnormal_cell_adhesion0.39454276
134MP0000249_abnormal_blood_vessel0.39261746
135MP0002083_premature_death0.38395761
136MP0003172_abnormal_lysosome_physiology0.37206384
137MP0004510_myositis0.36971041
138MP0003453_abnormal_keratinocyte_physiol0.36851269
139MP0008007_abnormal_cellular_replicative0.36626236
140MP0000367_abnormal_coat/_hair0.36220348
141MP0000627_abnormal_mammary_gland0.34705206
142MP0009384_cardiac_valve_regurgitation0.32545645
143MP0003077_abnormal_cell_cycle0.32039691
144MP0001663_abnormal_digestive_system0.31643860

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.49684570
2Abnormality of T cell number (HP:0011839)8.07211094
3Myositis (HP:0100614)6.09089153
4Severe combined immunodeficiency (HP:0004430)5.57432496
5Retrobulbar optic neuritis (HP:0100654)5.53760453
6Optic neuritis (HP:0100653)5.53760453
7Combined immunodeficiency (HP:0005387)5.51307971
8Nasal polyposis (HP:0100582)5.25611873
9Abnormality of T cells (HP:0002843)5.08116100
10Encephalitis (HP:0002383)4.99858435
11Orchitis (HP:0100796)4.88738280
12Keratoconjunctivitis sicca (HP:0001097)4.49629124
13Elevated erythrocyte sedimentation rate (HP:0003565)4.48672133
14Joint swelling (HP:0001386)4.35877372
15Abnormality of the nasal mucosa (HP:0000433)4.22292828
16Autoimmune hemolytic anemia (HP:0001890)4.15762890
17Keratoconjunctivitis (HP:0001096)4.07062836
18Increased IgM level (HP:0003496)3.87431114
19Stomatitis (HP:0010280)3.84035423
20IgG deficiency (HP:0004315)3.81304008
21Meningitis (HP:0001287)3.77677697
22Gastrointestinal infarctions (HP:0005244)3.77378904
23Recurrent bronchitis (HP:0002837)3.77241779
24Eczematoid dermatitis (HP:0000976)3.72989232
25Recurrent abscess formation (HP:0002722)3.67628514
26Renal cortical cysts (HP:0000803)3.51803454
27Pustule (HP:0200039)3.50583022
28Abnormality of eosinophils (HP:0001879)3.35538856
29Thyroiditis (HP:0100646)3.30949245
30Pulmonary infiltrates (HP:0002113)3.30711783
31Recurrent fungal infections (HP:0002841)3.27104615
32Abnormality of oral frenula (HP:0000190)3.25742261
33Chronic otitis media (HP:0000389)3.25296733
34Arterial thrombosis (HP:0004420)3.25207924
35Alveolar cell carcinoma (HP:0006519)3.20269213
36Hemoptysis (HP:0002105)3.20128276
37Recurrent viral infections (HP:0004429)3.17845212
38Leukocytosis (HP:0001974)3.16777870
39Pulmonary embolism (HP:0002204)3.12529817
40Chronic diarrhea (HP:0002028)3.09385665
41IgM deficiency (HP:0002850)3.01031879
42Vasculitis (HP:0002633)2.99999940
43Hypoproteinemia (HP:0003075)2.99321233
44Gangrene (HP:0100758)2.98941413
45Lymphopenia (HP:0001888)2.96870446
46Abnormality of the renal cortex (HP:0011035)2.95159096
47Panhypogammaglobulinemia (HP:0003139)2.89588729
48Chronic obstructive pulmonary disease (HP:0006510)2.88665159
49Obstructive lung disease (HP:0006536)2.88665159
50Hemiplegia (HP:0002301)2.88225775
51Mediastinal lymphadenopathy (HP:0100721)2.85896940
52Neoplasm of the tracheobronchial system (HP:0100552)2.82061471
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.78399877
54Anorexia (HP:0002039)2.76430088
55Inflammation of the large intestine (HP:0002037)2.73818177
56Conical tooth (HP:0000698)2.70712396
57Spontaneous hematomas (HP:0007420)2.62321553
58Gastrointestinal inflammation (HP:0004386)2.61092474
59Chronic mucocutaneous candidiasis (HP:0002728)2.51974990
60Recurrent cutaneous fungal infections (HP:0011370)2.51974990
61Anhidrosis (HP:0000970)2.51554869
62Eosinophilia (HP:0001880)2.45061140
63Abnormality of binocular vision (HP:0011514)2.44223931
64Diplopia (HP:0000651)2.44223931
65Abnormality of macrophages (HP:0004311)2.44172967
66Hypergammaglobulinemia (HP:0010702)2.43065489
67Trigonocephaly (HP:0000243)2.38721003
68Lymphoma (HP:0002665)2.37967248
69Aortic dissection (HP:0002647)2.37838063
70Abnormality of the prostate (HP:0008775)2.36630220
71Ureteral stenosis (HP:0000071)2.35624158
72Recurrent bacterial skin infections (HP:0005406)2.34847271
73Hypoalbuminemia (HP:0003073)2.33550207
74Abnormal albumin level (HP:0012116)2.33550207
75Pancreatic cysts (HP:0001737)2.33111797
76Recurrent sinusitis (HP:0011108)2.31611105
77Epistaxis (HP:0000421)2.30511547
78Glomerulopathy (HP:0100820)2.30119109
79Abnormality of T cell physiology (HP:0011840)2.25394672
80Stomach cancer (HP:0012126)2.23195654
81Keratitis (HP:0000491)2.22191043
82Autoimmune thrombocytopenia (HP:0001973)2.21382674
83Hypoplasia of the thymus (HP:0000778)2.20454208
84Abnormality of the pleura (HP:0002103)2.19763267
85Abnormal delayed hypersensitivity skin test (HP:0002963)2.18076741
86Nonimmune hydrops fetalis (HP:0001790)2.16936929
87Abnormality of B cell number (HP:0010975)2.16906847
88Abnormality of the fingertips (HP:0001211)2.15092710
89Polyneuropathy (HP:0001271)2.14964396
90Congenital stationary night blindness (HP:0007642)2.14319530
91Vertigo (HP:0002321)2.14144426
92Progressive inability to walk (HP:0002505)2.11220614
93Increased IgE level (HP:0003212)2.10919499
94Abnormality of the pericardium (HP:0001697)2.10831727
95Chest pain (HP:0100749)2.10365883
96Recurrent otitis media (HP:0000403)2.08652368
97Ureteral obstruction (HP:0006000)2.07734769
98Recurrent skin infections (HP:0001581)2.06564524
99Bronchitis (HP:0012387)2.05587638
100Pulmonary fibrosis (HP:0002206)2.04047740
101Recurrent gram-negative bacterial infections (HP:0005420)1.99917368
102Abnormality of the endocardium (HP:0004306)1.98084602
103Granulocytopenia (HP:0001913)1.96919202
104Bilateral sensorineural hearing impairment (HP:0008619)1.95958632
105Abnormal platelet volume (HP:0011876)1.95769597
106Amaurosis fugax (HP:0100576)1.95760211
107Abnormality of the common coagulation pathway (HP:0010990)1.94625787
108Prolonged bleeding time (HP:0003010)1.90796203
109Premature loss of primary teeth (HP:0006323)1.88360258
110Brittle hair (HP:0002299)1.84347011
111Persistence of primary teeth (HP:0006335)1.82306639
112Agammaglobulinemia (HP:0004432)1.81358300
113Dilatation of the ascending aorta (HP:0005111)1.80791864
114Increased serum ferritin (HP:0003281)1.80212665
115Aplastic anemia (HP:0001915)1.79313050
116Pancreatitis (HP:0001733)1.77135096
117B lymphocytopenia (HP:0010976)1.76296165
118Acrocyanosis (HP:0001063)1.76074444
119Arthralgia (HP:0002829)1.75725931
120Porencephaly (HP:0002132)1.72630612
121Abnormality of transition element cation homeostasis (HP:0011030)1.72514194
122Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69313341
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69313341
124Abolished electroretinogram (ERG) (HP:0000550)1.69066269
125Cutaneous melanoma (HP:0012056)1.64807922
126Acne (HP:0001061)1.62822479
127Progressive microcephaly (HP:0000253)1.62718937
128Adactyly (HP:0009776)1.62095614
129Thrombophlebitis (HP:0004418)1.60499262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.89174644
2ITK4.48492102
3MAP4K14.46360173
4ZAP703.25947575
5TAOK33.08433941
6MUSK3.05661129
7MST42.91763882
8JAK32.90104244
9STK102.56710969
10JAK12.55464015
11CSK2.48807241
12MAP4K22.37912567
13MAP3K142.24465149
14LCK2.16670771
15TESK22.03708580
16IRAK41.96374478
17MAP3K121.91603011
18IKBKE1.83818567
19TYK21.83291622
20CLK11.79958192
21GRK61.71489986
22TBK11.64505523
23BTK1.63510350
24ZAK1.59008297
25GRK71.58294371
26NLK1.56631553
27TEC1.54153602
28FRK1.41080273
29SYK1.38232383
30PRKCH1.33917536
31MAP2K61.32599271
32FGFR41.27511164
33BUB11.25126050
34MAP2K21.24571454
35FES1.21608200
36HCK1.20288623
37MATK1.20205059
38BLK1.19341984
39PRKCQ1.18843643
40PIK3CA1.16302154
41KDR1.13440181
42LRRK21.08300039
43TNK21.06110854
44EIF2AK21.03678723
45TGFBR21.03431311
46NUAK11.01405684
47RIPK10.98661643
48LYN0.97165082
49TYRO30.90689381
50PINK10.89088782
51FGFR30.88676818
52MELK0.83337236
53MAPKAPK30.82352031
54GRK10.82108272
55ADRBK20.79361901
56PIM10.78443579
57RPS6KA40.76155944
58MAP3K40.75945725
59TTN0.75260686
60BCKDK0.73139500
61MAPK110.73077164
62IKBKB0.69359719
63WNK40.68375992
64FYN0.67467903
65CDK90.66904001
66NME20.64732073
67DMPK0.64501643
68EPHB10.62466589
69CDK40.61030366
70CDK80.60457147
71IGF1R0.60114414
72CDC70.57906889
73INSR0.57417727
74MAPK130.56790866
75STK390.56418034
76PIK3CG0.55590045
77RAF10.54843892
78PDGFRB0.53920084
79NEK60.53718308
80LIMK10.50554905
81EPHA30.50297153
82ACVR1B0.50007770
83IRAK20.49074011
84STK40.49061310
85MAPKAPK20.48361136
86MYLK0.47968233
87MARK30.47045631
88NEK90.47038285
89CAMKK20.44377865
90JAK20.44097010
91MAP3K130.43920255
92ILK0.43413931
93TLK10.42796365
94RPS6KA50.42587395
95MAP3K70.42534543
96IRAK10.42381161
97BMPR20.36836624
98OXSR10.36603915
99BCR0.35984261
100ADRBK10.35721455
101TRIM280.34519192
102PHKG10.34329084
103PHKG20.34329084
104ABL10.34241742
105PRKCI0.33963619
106SIK20.33899626
107MAP3K100.33824262
108PRKCE0.33640060
109GRK50.33448285
110STK240.32536215
111MAP3K110.32184335
112KIT0.30133630
113DAPK20.29857264
114ERBB20.28408566
115PRKG20.27951435
116CDK30.27214679
117TSSK60.27070735
118FGFR10.26945667
119VRK10.26562679
120PRKCD0.26141941
121WNK30.25904812
122SRPK10.25149347
123CHUK0.24250665
124MOS0.23463422
125TIE10.23272407
126CSF1R0.22956723
127CSNK1A1L0.22679658
128EGFR0.22593029
129GSK3A0.22113388
130CSNK1G30.20848470
131PAK40.20433865
132DAPK10.20046357
133SRC0.19784375
134ALK0.19430164
135DAPK30.19084382
136TESK10.18762731
137SIK30.18572034
138STK380.17614245
139CSNK1A10.17546047
140PTK20.16926396
141PAK30.16609979
142MAPK70.15433518

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053327.73197675
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046505.18076888
3Primary immunodeficiency_Homo sapiens_hsa053404.47307332
4Allograft rejection_Homo sapiens_hsa053304.20165234
5* Antigen processing and presentation_Homo sapiens_hsa046123.98269139
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.42584111
7T cell receptor signaling pathway_Homo sapiens_hsa046603.36071471
8Type I diabetes mellitus_Homo sapiens_hsa049402.76280184
9Autoimmune thyroid disease_Homo sapiens_hsa053202.43323740
10Viral myocarditis_Homo sapiens_hsa054162.41973518
11Measles_Homo sapiens_hsa051622.37936861
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.28595449
13Hematopoietic cell lineage_Homo sapiens_hsa046401.74490910
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.74180367
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73864669
16Leishmaniasis_Homo sapiens_hsa051401.72115515
17Nitrogen metabolism_Homo sapiens_hsa009101.64639899
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.57811566
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54447923
20Malaria_Homo sapiens_hsa051441.48865749
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48658806
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.45159585
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41805522
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36331079
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.34821592
26Osteoclast differentiation_Homo sapiens_hsa043801.29247783
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28753507
28Chemokine signaling pathway_Homo sapiens_hsa040621.16903864
29Linoleic acid metabolism_Homo sapiens_hsa005911.16292188
30B cell receptor signaling pathway_Homo sapiens_hsa046621.11510517
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07298510
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05769668
33Staphylococcus aureus infection_Homo sapiens_hsa051501.02255523
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97339021
35Herpes simplex infection_Homo sapiens_hsa051680.96028155
36Apoptosis_Homo sapiens_hsa042100.92503052
37NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92051262
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91967906
39Phototransduction_Homo sapiens_hsa047440.91788427
40Asthma_Homo sapiens_hsa053100.88570991
41Rheumatoid arthritis_Homo sapiens_hsa053230.87317186
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85606515
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83856273
44Shigellosis_Homo sapiens_hsa051310.83358441
45Toxoplasmosis_Homo sapiens_hsa051450.82018209
46Pancreatic cancer_Homo sapiens_hsa052120.78997682
47HTLV-I infection_Homo sapiens_hsa051660.78563295
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78023497
49Influenza A_Homo sapiens_hsa051640.71685782
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71365860
51Colorectal cancer_Homo sapiens_hsa052100.71227907
52Hepatitis B_Homo sapiens_hsa051610.69446549
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66823729
54VEGF signaling pathway_Homo sapiens_hsa043700.66717375
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64526656
56Platelet activation_Homo sapiens_hsa046110.64176298
57TNF signaling pathway_Homo sapiens_hsa046680.62753797
58Proteasome_Homo sapiens_hsa030500.61587988
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60744059
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58732091
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57667610
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57482461
63Salmonella infection_Homo sapiens_hsa051320.57243946
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57138657
65Pertussis_Homo sapiens_hsa051330.56579961
66Legionellosis_Homo sapiens_hsa051340.55817842
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55369248
68Epstein-Barr virus infection_Homo sapiens_hsa051690.54593333
69Taste transduction_Homo sapiens_hsa047420.53309506
70Tuberculosis_Homo sapiens_hsa051520.52840631
71RNA polymerase_Homo sapiens_hsa030200.52661940
72Morphine addiction_Homo sapiens_hsa050320.50966147
73Regulation of autophagy_Homo sapiens_hsa041400.49287829
74Olfactory transduction_Homo sapiens_hsa047400.49081090
75Ribosome_Homo sapiens_hsa030100.47916861
76Basal transcription factors_Homo sapiens_hsa030220.47639010
77Sulfur metabolism_Homo sapiens_hsa009200.47329312
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47026036
79Hepatitis C_Homo sapiens_hsa051600.45786257
80Peroxisome_Homo sapiens_hsa041460.42921410
81DNA replication_Homo sapiens_hsa030300.41986951
82Arachidonic acid metabolism_Homo sapiens_hsa005900.41087339
83Endocytosis_Homo sapiens_hsa041440.40447212
84Retinol metabolism_Homo sapiens_hsa008300.35802276
85Ether lipid metabolism_Homo sapiens_hsa005650.34986002
86Mismatch repair_Homo sapiens_hsa034300.34020257
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33629174
88Fanconi anemia pathway_Homo sapiens_hsa034600.32283937
89Acute myeloid leukemia_Homo sapiens_hsa052210.32044545
90Chemical carcinogenesis_Homo sapiens_hsa052040.31015677
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30565196
92p53 signaling pathway_Homo sapiens_hsa041150.30457556
93Dorso-ventral axis formation_Homo sapiens_hsa043200.29139215
94Adherens junction_Homo sapiens_hsa045200.28973969
95Chronic myeloid leukemia_Homo sapiens_hsa052200.28203847
96ABC transporters_Homo sapiens_hsa020100.27892673
97Rap1 signaling pathway_Homo sapiens_hsa040150.26927926
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.26778138
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.26680995
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.26472507
101Nucleotide excision repair_Homo sapiens_hsa034200.26069592
102Renal cell carcinoma_Homo sapiens_hsa052110.25143234
103Caffeine metabolism_Homo sapiens_hsa002320.25102162
104Viral carcinogenesis_Homo sapiens_hsa052030.24665147
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24630750
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.24302979
107Focal adhesion_Homo sapiens_hsa045100.23979215
108African trypanosomiasis_Homo sapiens_hsa051430.23495791
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21854109
110Nicotine addiction_Homo sapiens_hsa050330.21568981
111Non-homologous end-joining_Homo sapiens_hsa034500.21438347
112Homologous recombination_Homo sapiens_hsa034400.21117091
113Glycerolipid metabolism_Homo sapiens_hsa005610.20689267
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20516091
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.20040466
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19337337
117N-Glycan biosynthesis_Homo sapiens_hsa005100.18800506
118Salivary secretion_Homo sapiens_hsa049700.18667161
119Non-small cell lung cancer_Homo sapiens_hsa052230.18344446
120Prion diseases_Homo sapiens_hsa050200.17495476
121RNA degradation_Homo sapiens_hsa030180.17481595
122Base excision repair_Homo sapiens_hsa034100.15366793
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12904668
124FoxO signaling pathway_Homo sapiens_hsa040680.12131592
125Pentose phosphate pathway_Homo sapiens_hsa000300.11550880
126Amoebiasis_Homo sapiens_hsa051460.06846971
127Small cell lung cancer_Homo sapiens_hsa052220.05740439
128Spliceosome_Homo sapiens_hsa030400.05306530
129Prolactin signaling pathway_Homo sapiens_hsa049170.04576584
130MAPK signaling pathway_Homo sapiens_hsa040100.03114944
131Lysosome_Homo sapiens_hsa041420.00602908
132mRNA surveillance pathway_Homo sapiens_hsa03015-0.0611509
133Pathways in cancer_Homo sapiens_hsa05200-0.0579998
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0540585
135Ras signaling pathway_Homo sapiens_hsa04014-0.0421809
136Choline metabolism in cancer_Homo sapiens_hsa05231-0.0414194
137Protein export_Homo sapiens_hsa03060-0.0342280
138Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0291918
139Pyrimidine metabolism_Homo sapiens_hsa00240-0.0165991
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0101405
141Notch signaling pathway_Homo sapiens_hsa04330-0.0059896

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