KLRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.99251732
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.99251732
3regulation of isotype switching to IgG isotypes (GO:0048302)8.91724541
4negative T cell selection (GO:0043383)8.39154043
5negative thymic T cell selection (GO:0045060)8.19353288
6regulation of natural killer cell mediated immunity (GO:0002715)8.03042104
7regulation of natural killer cell mediated cytotoxicity (GO:0042269)8.03042104
8cellular response to interleukin-15 (GO:0071350)7.80759333
9positive regulation of gamma-delta T cell activation (GO:0046645)7.01837779
10positive thymic T cell selection (GO:0045059)6.95082232
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.90885676
12positive regulation of natural killer cell mediated immunity (GO:0002717)6.90885676
13response to interleukin-15 (GO:0070672)6.81687429
14thymic T cell selection (GO:0045061)6.58235696
15activated T cell proliferation (GO:0050798)6.37747694
16positive T cell selection (GO:0043368)6.23789373
17T cell migration (GO:0072678)6.23610747
18regulation of B cell receptor signaling pathway (GO:0050855)5.97070080
19negative regulation by host of viral transcription (GO:0043922)5.86569517
20regulation of leukocyte mediated cytotoxicity (GO:0001910)5.84917739
21regulation of lymphocyte chemotaxis (GO:1901623)5.84336923
22positive regulation of isotype switching (GO:0045830)5.79696962
23positive regulation of defense response to virus by host (GO:0002230)5.76013039
24pyrimidine nucleoside catabolic process (GO:0046135)5.67785428
25leukocyte aggregation (GO:0070486)5.59537220
26regulation of gamma-delta T cell differentiation (GO:0045586)5.55968007
27T cell selection (GO:0045058)5.50908232
28regulation of cell killing (GO:0031341)5.36714409
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.29776114
30positive regulation of DNA recombination (GO:0045911)5.24515030
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.18547150
32positive regulation of immunoglobulin mediated immune response (GO:0002891)5.10561519
33positive regulation of B cell mediated immunity (GO:0002714)5.10561519
34natural killer cell activation (GO:0030101)5.03755485
35regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.03232938
36T cell costimulation (GO:0031295)4.98997947
37regulation of response to tumor cell (GO:0002834)4.97951842
38positive regulation of response to tumor cell (GO:0002836)4.97951842
39positive regulation of immune response to tumor cell (GO:0002839)4.97951842
40regulation of immune response to tumor cell (GO:0002837)4.97951842
41positive regulation of cell killing (GO:0031343)4.97270137
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.96826844
43cytolysis (GO:0019835)4.95404850
44regulation of gamma-delta T cell activation (GO:0046643)4.95009907
45lymphocyte costimulation (GO:0031294)4.93285558
46positive regulation of calcium-mediated signaling (GO:0050850)4.92818703
47eosinophil chemotaxis (GO:0048245)4.90617236
48positive regulation of T cell mediated cytotoxicity (GO:0001916)4.86175828
49T cell receptor signaling pathway (GO:0050852)4.85836228
50positive regulation of alpha-beta T cell proliferation (GO:0046641)4.74444459
51regulation of interleukin-12 biosynthetic process (GO:0045075)4.71157153
52regulation of isotype switching (GO:0045191)4.67556753
53negative regulation of viral genome replication (GO:0045071)4.55860321
54lymphocyte chemotaxis (GO:0048247)4.54045680
55regulation of immunoglobulin mediated immune response (GO:0002889)4.51066901
56* cellular defense response (GO:0006968)4.45664507
57regulation of regulatory T cell differentiation (GO:0045589)4.44061363
58positive regulation of lymphocyte migration (GO:2000403)4.43741942
59negative regulation of T cell mediated immunity (GO:0002710)4.41617244
60eosinophil migration (GO:0072677)4.40133941
61regulation of alpha-beta T cell proliferation (GO:0046640)4.39042319
62regulation of B cell mediated immunity (GO:0002712)4.34634341
63negative regulation of T cell apoptotic process (GO:0070233)4.24344676
64antigen receptor-mediated signaling pathway (GO:0050851)4.19907425
65sequestering of actin monomers (GO:0042989)4.13685339
66T cell differentiation involved in immune response (GO:0002292)4.13214564
67alpha-beta T cell differentiation involved in immune response (GO:0002293)4.13214564
68alpha-beta T cell activation involved in immune response (GO:0002287)4.13214564
69regulation of T cell tolerance induction (GO:0002664)4.11966436
70regulation of memory T cell differentiation (GO:0043380)4.09421761
71regulation of lymphocyte mediated immunity (GO:0002706)4.08510262
72negative regulation of viral transcription (GO:0032897)4.08473971
73cellular response to interferon-beta (GO:0035458)4.03996992
74response to interferon-beta (GO:0035456)4.01694975
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.01484054
76lymphocyte migration (GO:0072676)3.99368997
77macrophage chemotaxis (GO:0048246)3.97569206
78regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.95179694
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.95164578
80positive regulation of lymphocyte mediated immunity (GO:0002708)3.94469336
81positive regulation of T cell cytokine production (GO:0002726)3.93281957
82regulation of response to interferon-gamma (GO:0060330)3.91124726
83leukocyte cell-cell adhesion (GO:0007159)3.89750421
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.83429800
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81842919
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81842919
87negative regulation of lymphocyte mediated immunity (GO:0002707)3.79025270
88T cell differentiation (GO:0030217)3.71723819
89positive regulation of immunoglobulin production (GO:0002639)3.70640811
90regulation of T cell receptor signaling pathway (GO:0050856)3.67361650
91DNA demethylation (GO:0080111)3.65205440
92regulation of activation of Janus kinase activity (GO:0010533)3.63841350
93positive regulation of B cell differentiation (GO:0045579)3.60862862
94regulation of B cell differentiation (GO:0045577)3.58884005
95regulation of calcium-mediated signaling (GO:0050848)3.57916149
96alpha-beta T cell differentiation (GO:0046632)3.54229457
97cellular extravasation (GO:0045123)3.53626814
98negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.53529223
99alpha-beta T cell activation (GO:0046631)3.52395762
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.52299429
101modulation by host of symbiont transcription (GO:0052472)3.52008625
102modulation by host of viral transcription (GO:0043921)3.52008625
103T-helper cell differentiation (GO:0042093)3.51007385
104CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.51007385
105positive regulation of interleukin-8 secretion (GO:2000484)3.49016460
106regulation of histone H3-K27 methylation (GO:0061085)3.48802161
107positive regulation of T cell mediated immunity (GO:0002711)3.48373532
108negative regulation of viral process (GO:0048525)3.46855923
109positive regulation of humoral immune response (GO:0002922)3.45306106
110regulation of T cell mediated cytotoxicity (GO:0001914)3.44763531
111negative regulation of T cell receptor signaling pathway (GO:0050860)3.43724737
112heterotypic cell-cell adhesion (GO:0034113)3.39980430
113pyrimidine ribonucleoside metabolic process (GO:0046131)3.38960205
114positive regulation of leukocyte mediated immunity (GO:0002705)3.37208820
115T cell activation (GO:0042110)3.36911737
116regulation of lymphocyte migration (GO:2000401)3.35997100
117T cell activation involved in immune response (GO:0002286)3.35971163
118regulation of defense response to virus by host (GO:0050691)3.35032812
119T cell proliferation (GO:0042098)3.34716431
120regulation of viral genome replication (GO:0045069)3.31594059
121regulation of immunoglobulin production (GO:0002637)3.31333741
122modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)3.31169848
123positive regulation of T cell chemotaxis (GO:0010820)3.30352079
124regulation of T cell chemotaxis (GO:0010819)3.30352079
125negative regulation of type 2 immune response (GO:0002829)3.26039197
126regulation of leukocyte mediated immunity (GO:0002703)3.21663469
127positive regulation of tolerance induction (GO:0002645)3.20268026
128pyrimidine-containing compound catabolic process (GO:0072529)3.19098692
129positive regulation of macrophage differentiation (GO:0045651)3.16479734
130antigen processing and presentation of endogenous antigen (GO:0019883)3.16197586
131regulation of type I interferon-mediated signaling pathway (GO:0060338)3.15973535
132negative regulation of adaptive immune response (GO:0002820)3.15332597
133Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14290115
134positive regulation of lamellipodium assembly (GO:0010592)3.12353583
135positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.11093719
136mast cell activation (GO:0045576)3.09015633
137granulocyte activation (GO:0036230)3.06266103
138positive regulation of T-helper 1 type immune response (GO:0002827)2.96906407
139positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.95783686
140regulation of T cell mediated immunity (GO:0002709)2.94822173
141regulation of T-helper 1 type immune response (GO:0002825)2.94405733
142DNA dealkylation (GO:0035510)2.91139899
143negative regulation of lymphocyte apoptotic process (GO:0070229)2.91010340
144negative regulation of alpha-beta T cell activation (GO:0046636)2.90756742
145positive regulation of activated T cell proliferation (GO:0042104)2.90552170
146leukocyte degranulation (GO:0043299)2.88384518
147negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88316541
148negative regulation of leukocyte mediated immunity (GO:0002704)2.88261510
149cytidine metabolic process (GO:0046087)13.1493662
150cytidine catabolic process (GO:0006216)13.1493662
151cytidine deamination (GO:0009972)13.1493662
152pyrimidine ribonucleoside catabolic process (GO:0046133)11.8946169
153interferon-gamma production (GO:0032609)10.6222677
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:004509110.2636847
155DNA deamination (GO:0045006)10.0256958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.02315924
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.24339980
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.86107638
4RUNX_20019798_ChIP-Seq_JUKART_Human4.32551035
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.25122278
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.04561111
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.96094141
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.76917458
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.65800680
10MYB_26560356_Chip-Seq_TH2_Human3.59722295
11MAF_26560356_Chip-Seq_TH1_Human3.20614765
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17338578
13MYB_26560356_Chip-Seq_TH1_Human3.10275744
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.09928016
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83119649
16UTX_26944678_Chip-Seq_JUKART_Human2.79768179
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.76693321
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73215305
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60288936
20MYC_22102868_ChIP-Seq_BL_Human2.52371900
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.47444921
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.30122106
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.16759242
24GATA3_27048872_Chip-Seq_THYMUS_Human2.15303545
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.11113314
26E2F7_22180533_ChIP-Seq_HELA_Human2.10362171
27SPI1_23547873_ChIP-Seq_NB4_Human2.03061387
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98469222
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98062491
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96706535
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94042962
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92434217
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92126214
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91504628
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89635424
36VDR_22108803_ChIP-Seq_LS180_Human1.88045387
37MAF_26560356_Chip-Seq_TH2_Human1.85112671
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79890256
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76823177
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74484704
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70332085
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68294087
43SCL_19346495_ChIP-Seq_HPC-7_Human1.58959387
44TCF7_22412390_ChIP-Seq_EML_Mouse1.56454638
45VDR_21846776_ChIP-Seq_THP-1_Human1.51791641
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46609001
47VDR_24763502_ChIP-Seq_THP-1_Human1.43722838
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43521796
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.43421800
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38240784
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38090844
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.37018024
53SPI1_23127762_ChIP-Seq_K562_Human1.34693541
54GATA3_26560356_Chip-Seq_TH2_Human1.34245645
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.32366679
56PU_27001747_Chip-Seq_BMDM_Mouse1.29623669
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27345836
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25596909
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25525021
60IRF1_19129219_ChIP-ChIP_H3396_Human1.25154845
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21075670
62KDM2B_26808549_Chip-Seq_DND41_Human1.18770667
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17744581
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13681588
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13619443
66* HTT_18923047_ChIP-ChIP_STHdh_Human1.13149305
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11612143
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09941933
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08386512
70* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08230444
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06248510
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05163340
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04645834
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04029792
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03839015
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03058751
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01009521
78GATA3_26560356_Chip-Seq_TH1_Human1.00218506
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98981958
80VDR_24787735_ChIP-Seq_THP-1_Human0.98782202
81KDM2B_26808549_Chip-Seq_JURKAT_Human0.98133441
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97503102
83ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96513576
84KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96311083
85VDR_23849224_ChIP-Seq_CD4+_Human0.95201417
86* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93863384
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92652735
88EGR1_19032775_ChIP-ChIP_M12_Human0.92580425
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91950472
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90309488
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.89458286
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85776458
93BP1_19119308_ChIP-ChIP_Hs578T_Human0.84422170
94BCL6_27268052_Chip-Seq_Bcells_Human0.84124943
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.83728605
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83284122
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82930261
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82528011
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79728560
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79068763
101NFE2_27457419_Chip-Seq_LIVER_Mouse0.78850180
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78517372
103* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78106373
104* FOXA1_25329375_ChIP-Seq_VCAP_Human0.78106373
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.78076537
106TAF2_19829295_ChIP-Seq_ESCs_Human0.77696279
107FOXP3_21729870_ChIP-Seq_TREG_Human0.77001008
108NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.76897278
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76768624
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.76100273
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.75944456
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.75330593
113NCOR1_26117541_ChIP-Seq_K562_Human0.74472213
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.74470365
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72990109
116NANOG_20526341_ChIP-Seq_ESCs_Human0.72785891
117P300_27268052_Chip-Seq_Bcells_Human0.72022042
118TP53_22573176_ChIP-Seq_HFKS_Human0.71446203
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.71387172
120E2F4_17652178_ChIP-ChIP_JURKAT_Human0.70532231
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.69834969
122FLI1_21867929_ChIP-Seq_CD8_Mouse0.69831274
123RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69215690
124EST1_17652178_ChIP-ChIP_JURKAT_Human0.69113995
125MYC_19829295_ChIP-Seq_ESCs_Human0.69078239
126GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.68002809
127SPI1_20517297_ChIP-Seq_HL60_Human0.67878167
128VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.67380565
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67363357
130GBX2_23144817_ChIP-Seq_PC3_Human0.66247262
131GATA2_19941826_ChIP-Seq_K562_Human0.65535336
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64256286
133GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63812030
134GATA6_21074721_ChIP-Seq_CACO-2_Human0.63407869
135* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.62982457
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62845577
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.62637602
138AR_20517297_ChIP-Seq_VCAP_Human0.62292369
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.61923364
140TDRD3_21172665_ChIP-Seq_MCF-7_Human0.61488433
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61407735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.65911773
2MP0003763_abnormal_thymus_physiology5.18058081
3MP0006082_CNS_inflammation4.89639160
4MP0009785_altered_susceptibility_to4.00463647
5MP0001800_abnormal_humoral_immune3.29621228
6MP0000569_abnormal_digit_pigmentation3.09668779
7MP0002420_abnormal_adaptive_immunity3.09278277
8MP0001819_abnormal_immune_cell3.04928037
9MP0001835_abnormal_antigen_presentation3.02426978
10MP0005025_abnormal_response_to3.00762767
11MP0005000_abnormal_immune_tolerance2.97433708
12MP0002723_abnormal_immune_serum2.93486810
13MP0009333_abnormal_splenocyte_physiolog2.89625221
14MP0001790_abnormal_immune_system2.79767162
15MP0005387_immune_system_phenotype2.79767162
16MP0000685_abnormal_immune_system2.79548558
17MP0000858_altered_metastatic_potential2.74845516
18MP0002398_abnormal_bone_marrow2.72183702
19MP0002166_altered_tumor_susceptibility2.66932525
20MP0003448_altered_tumor_morphology2.63330894
21MP0002006_tumorigenesis2.60525352
22MP0002452_abnormal_antigen_presenting2.59927699
23MP0000716_abnormal_immune_system2.41219988
24MP0002405_respiratory_system_inflammati2.39879007
25MP0000703_abnormal_thymus_morphology2.33359867
26MP0001873_stomach_inflammation2.30304327
27MP0003724_increased_susceptibility_to2.27547105
28MP0002722_abnormal_immune_system2.17040029
29MP0002009_preneoplasia2.16123010
30MP0003436_decreased_susceptibility_to2.12701623
31MP0002148_abnormal_hypersensitivity_rea2.05028298
32MP0000689_abnormal_spleen_morphology2.04962328
33MP0003866_abnormal_defecation1.96540330
34MP0003183_abnormal_peptide_metabolism1.94790972
35MP0002429_abnormal_blood_cell1.91540640
36MP0010155_abnormal_intestine_physiology1.86910909
37MP0002419_abnormal_innate_immunity1.84980743
38MP0004947_skin_inflammation1.84803373
39MP0004381_abnormal_hair_follicle1.77872832
40MP0003786_premature_aging1.70163081
41MP0001845_abnormal_inflammatory_respons1.68376443
42MP0002163_abnormal_gland_morphology1.65694530
43MP0002132_abnormal_respiratory_system1.64334733
44MP0002933_joint_inflammation1.56989309
45MP0005464_abnormal_platelet_physiology1.48916342
46MP0002837_dystrophic_cardiac_calcinosis1.42022097
47MP0008469_abnormal_protein_level1.35713522
48MP0002396_abnormal_hematopoietic_system1.34177852
49MP0003045_fibrosis1.32396516
50MP0004510_myositis1.32025648
51MP0002877_abnormal_melanocyte_morpholog1.30175647
52MP0001851_eye_inflammation1.29730276
53MP0002277_abnormal_respiratory_mucosa1.25327791
54MP0002019_abnormal_tumor_incidence1.25185421
55MP0000490_abnormal_crypts_of1.17711878
56MP0005310_abnormal_salivary_gland1.16291109
57MP0002736_abnormal_nociception_after1.15015998
58MP0003300_gastrointestinal_ulcer1.14719826
59MP0002876_abnormal_thyroid_physiology1.11123634
60MP0008877_abnormal_DNA_methylation1.10449568
61MP0009763_increased_sensitivity_to1.01579211
62MP0002998_abnormal_bone_remodeling1.01457386
63MP0010307_abnormal_tumor_latency0.97871482
64MP0008007_abnormal_cellular_replicative0.94647211
65MP0001533_abnormal_skeleton_physiology0.94144703
66MP0005167_abnormal_blood-brain_barrier0.91944553
67MP0003950_abnormal_plasma_membrane0.91747015
68MP0001968_abnormal_touch/_nociception0.88263677
69MP0005075_abnormal_melanosome_morpholog0.87409614
70MP0004742_abnormal_vestibular_system0.87026612
71MP0005165_increased_susceptibility_to0.86825121
72MP0005166_decreased_susceptibility_to0.83971163
73MP0005377_hearing/vestibular/ear_phenot0.79972628
74MP0003878_abnormal_ear_physiology0.79972628
75MP0005408_hypopigmentation0.78074067
76MP0005451_abnormal_body_composition0.76442147
77MP0001853_heart_inflammation0.76373361
78MP0001502_abnormal_circadian_rhythm0.75991812
79MP0001986_abnormal_taste_sensitivity0.75221146
80MP0000465_gastrointestinal_hemorrhage0.74929880
81MP0000920_abnormal_myelination0.74884311
82MP0000015_abnormal_ear_pigmentation0.73339328
83MP0003959_abnormal_lean_body0.72717501
84MP0005379_endocrine/exocrine_gland_phen0.72449875
85MP0005253_abnormal_eye_physiology0.72374179
86MP0009764_decreased_sensitivity_to0.72308114
87MP0001919_abnormal_reproductive_system0.71480296
88MP0003453_abnormal_keratinocyte_physiol0.71470236
89MP0003075_altered_response_to0.71055625
90MP0005174_abnormal_tail_pigmentation0.69751597
91MP0000613_abnormal_salivary_gland0.68900728
92MP0006072_abnormal_retinal_apoptosis0.68196344
93MP0000343_altered_response_to0.66589266
94MP0002095_abnormal_skin_pigmentation0.66276932
95MP0004142_abnormal_muscle_tone0.66092890
96MP0005410_abnormal_fertilization0.64338633
97MP0003880_abnormal_central_pattern0.63412496
98MP0001765_abnormal_ion_homeostasis0.62850719
99MP0002138_abnormal_hepatobiliary_system0.62761574
100MP0009765_abnormal_xenobiotic_induced0.61163203
101MP0004808_abnormal_hematopoietic_stem0.59242009
102MP0002653_abnormal_ependyma_morphology0.58966039
103MP0005636_abnormal_mineral_homeostasis0.58955665
104MP0002136_abnormal_kidney_physiology0.58751837
105MP0000372_irregular_coat_pigmentation0.57127279
106MP0005023_abnormal_wound_healing0.55280128
107MP0002693_abnormal_pancreas_physiology0.55050754
108MP0003303_peritoneal_inflammation0.54102356
109MP0001243_abnormal_dermal_layer0.53786026
110MP0000427_abnormal_hair_cycle0.52489969
111MP0008873_increased_physiological_sensi0.51421948
112MP0001188_hyperpigmentation0.50410716
113MP0008058_abnormal_DNA_repair0.49738403
114MP0001501_abnormal_sleep_pattern0.49247516
115MP0005076_abnormal_cell_differentiation0.47798660
116MP0002168_other_aberrant_phenotype0.47123413
117MP0003943_abnormal_hepatobiliary_system0.46243558
118MP0001905_abnormal_dopamine_level0.45564938
119MP0000609_abnormal_liver_physiology0.44732084
120MP0009379_abnormal_foot_pigmentation0.42961536
121MP0001663_abnormal_digestive_system0.42489973
122MP0000477_abnormal_intestine_morphology0.42292199
123MP0003172_abnormal_lysosome_physiology0.42195483
124MP0008569_lethality_at_weaning0.39302419
125MP0002083_premature_death0.39167220
126MP0001191_abnormal_skin_condition0.39117152
127MP0009643_abnormal_urine_homeostasis0.38541514
128MP0004957_abnormal_blastocyst_morpholog0.37758004
129MP0006054_spinal_hemorrhage0.34546949
130MP0006292_abnormal_olfactory_placode0.34248707
131MP0005584_abnormal_enzyme/coenzyme_acti0.33736074
132MP0003795_abnormal_bone_structure0.33516862
133MP0000249_abnormal_blood_vessel0.31796712
134MP0000367_abnormal_coat/_hair0.31486463
135MP0000371_diluted_coat_color0.31112066

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.87540074
2Abnormality of T cell number (HP:0011839)7.53858653
3Severe combined immunodeficiency (HP:0004430)5.80624413
4Aplastic anemia (HP:0001915)5.44436023
5Combined immunodeficiency (HP:0005387)5.34350988
6Retrobulbar optic neuritis (HP:0100654)5.29872743
7Optic neuritis (HP:0100653)5.29872743
8Myositis (HP:0100614)5.23375286
9Abnormality of T cells (HP:0002843)5.07903906
10Encephalitis (HP:0002383)4.95604468
11Orchitis (HP:0100796)4.56841610
12Nasal polyposis (HP:0100582)4.39307599
13Meningitis (HP:0001287)4.23120126
14Elevated erythrocyte sedimentation rate (HP:0003565)4.20823945
15Gastrointestinal infarctions (HP:0005244)4.17157590
16Joint swelling (HP:0001386)4.13467910
17IgG deficiency (HP:0004315)4.05474519
18Increased IgM level (HP:0003496)4.00890444
19Thyroiditis (HP:0100646)3.96252064
20Stomatitis (HP:0010280)3.93651936
21Hypoproteinemia (HP:0003075)3.91964856
22Keratoconjunctivitis sicca (HP:0001097)3.75119673
23Recurrent fungal infections (HP:0002841)3.75058566
24Eczematoid dermatitis (HP:0000976)3.72608475
25Abnormality of eosinophils (HP:0001879)3.68685158
26Hemoptysis (HP:0002105)3.65783453
27Recurrent bronchitis (HP:0002837)3.58195579
28Abnormality of the nasal mucosa (HP:0000433)3.50206937
29IgM deficiency (HP:0002850)3.49513690
30Recurrent cutaneous fungal infections (HP:0011370)3.45291936
31Chronic mucocutaneous candidiasis (HP:0002728)3.45291936
32Hemiplegia (HP:0002301)3.44156200
33Pulmonary infiltrates (HP:0002113)3.41393698
34Obstructive lung disease (HP:0006536)3.41187137
35Chronic obstructive pulmonary disease (HP:0006510)3.41187137
36Keratoconjunctivitis (HP:0001096)3.38593388
37Carpal bone hypoplasia (HP:0001498)3.38455370
38Vasculitis (HP:0002633)3.31913400
39Autoimmune hemolytic anemia (HP:0001890)3.27079566
40Leukocytosis (HP:0001974)3.25988613
41Chronic diarrhea (HP:0002028)3.20358006
42Arterial thrombosis (HP:0004420)3.16952253
43Recurrent abscess formation (HP:0002722)3.10454436
44Panhypogammaglobulinemia (HP:0003139)3.10103000
45Gangrene (HP:0100758)3.09533523
46Pulmonary embolism (HP:0002204)3.09144465
47Recurrent viral infections (HP:0004429)2.99350045
48Hyponatremia (HP:0002902)2.98497509
49Cutaneous melanoma (HP:0012056)2.95546681
50Mediastinal lymphadenopathy (HP:0100721)2.91060426
51Abnormality of binocular vision (HP:0011514)2.80291134
52Diplopia (HP:0000651)2.80291134
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.78492925
54Pustule (HP:0200039)2.78370855
55Eosinophilia (HP:0001880)2.78243800
56Abnormality of the prostate (HP:0008775)2.76274357
57Abnormality of T cell physiology (HP:0011840)2.76092058
58Menstrual irregularities (HP:0000858)2.75072113
59Anorexia (HP:0002039)2.71006445
60Abnormality of macrophages (HP:0004311)2.70455719
61Ureteral stenosis (HP:0000071)2.68527800
62Lymphopenia (HP:0001888)2.66728825
63Spontaneous hematomas (HP:0007420)2.66563099
64Lymphoma (HP:0002665)2.59395706
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.54623469
66IgA deficiency (HP:0002720)2.54066581
67Inflammation of the large intestine (HP:0002037)2.51658115
68Hypergammaglobulinemia (HP:0010702)2.50374664
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.47216327
70Abnormality of the fingertips (HP:0001211)2.46781881
71Hypoplasia of the thymus (HP:0000778)2.45861081
72Gastrointestinal inflammation (HP:0004386)2.45207388
73Increased IgE level (HP:0003212)2.41799837
74Ureteral obstruction (HP:0006000)2.38712471
75Recurrent sinusitis (HP:0011108)2.35920568
76Chest pain (HP:0100749)2.33863966
77Epistaxis (HP:0000421)2.32417051
78Glomerulopathy (HP:0100820)2.30927640
79Agammaglobulinemia (HP:0004432)2.30881797
80Abnormality of sodium homeostasis (HP:0010931)2.30665200
81Purpura (HP:0000979)2.25636597
82Hypoalbuminemia (HP:0003073)2.22952604
83Abnormal albumin level (HP:0012116)2.22952604
84Recurrent skin infections (HP:0001581)2.22612636
85Granulocytopenia (HP:0001913)2.21533862
86Abnormality of oral frenula (HP:0000190)2.19913989
87Keratitis (HP:0000491)2.16660503
88Increased serum ferritin (HP:0003281)2.16521056
89Aortic dissection (HP:0002647)2.15758856
90Gingivitis (HP:0000230)2.13787959
91Amaurosis fugax (HP:0100576)2.12698246
92Abnormality of liposaccharide metabolism (HP:0010968)2.12270770
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.12270770
94Abnormality of glycolipid metabolism (HP:0010969)2.12270770
95Abnormality of the pleura (HP:0002103)2.12172142
96Hepatosplenomegaly (HP:0001433)2.11354796
97Polyneuropathy (HP:0001271)2.09288346
98Abnormality of the common coagulation pathway (HP:0010990)2.06126784
99Pigmentary retinal degeneration (HP:0001146)2.03846119
100Chronic otitis media (HP:0000389)2.01068741
101Acrocyanosis (HP:0001063)2.00371993
102Autoimmune thrombocytopenia (HP:0001973)1.99789145
103Frequent falls (HP:0002359)1.98933957
104Prolonged neonatal jaundice (HP:0006579)1.98442722
105J-shaped sella turcica (HP:0002680)1.94727877
106Tetraplegia (HP:0002445)1.92556970
107Cheilitis (HP:0100825)1.90430602
108Microcytic anemia (HP:0001935)1.90424532
109Bronchitis (HP:0012387)1.89330904
110Decreased circulating renin level (HP:0003351)1.88511910
111Abnormality of the pericardium (HP:0001697)1.88346574
112Petechiae (HP:0000967)1.86624476
113Renal cortical cysts (HP:0000803)1.86367365
114Periodontitis (HP:0000704)1.85239892
115Increased CSF protein (HP:0002922)1.83087102
116Acute hepatic failure (HP:0006554)1.82210655
117Pancytopenia (HP:0001876)1.81490994
118Alveolar cell carcinoma (HP:0006519)1.79844882
119Abnormality of the endocardium (HP:0004306)1.79048044
120Basal ganglia calcification (HP:0002135)1.78046940
121Porencephaly (HP:0002132)1.76992698
1223-Methylglutaconic aciduria (HP:0003535)1.75009565
123Congenital stationary night blindness (HP:0007642)1.74725954
124Recurrent bacterial skin infections (HP:0005406)1.73632684
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71210823
126Pulmonary fibrosis (HP:0002206)1.71109926
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.70728268
128Arthralgia (HP:0002829)1.69249552
129Acne (HP:0001061)1.67768043
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66575857
131Skin rash (HP:0000988)1.65010976
132Neuroendocrine neoplasm (HP:0100634)1.64853799
133Glucose intolerance (HP:0000833)1.64853677
134Retinopathy (HP:0000488)1.63819791
135Squamous cell carcinoma (HP:0002860)1.61649663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.45315443
2ITK4.03900047
3MAP4K13.91237721
4JAK12.88109889
5JAK32.77853731
6TSSK62.53348720
7TESK22.45235648
8ZAP702.44880088
9PIK3CA2.35126606
10MST42.32801958
11STK382.26994887
12STK102.24328902
13PRKD22.23832354
14CSK2.17757875
15GRK62.12739787
16NLK2.07496168
17CLK11.98154451
18LCK1.93630780
19IKBKE1.93500155
20GRK71.91742721
21IRAK41.84027994
22FGFR41.79703644
23EIF2AK31.62169886
24KDR1.59847406
25MAP3K141.53609116
26TEC1.52403954
27TBK11.50921750
28TYK21.48451114
29MAP3K121.43996917
30BTK1.43676808
31FGFR31.35690839
32MAPKAPK31.33098851
33TLK11.22929463
34WNK41.22803978
35PRKCQ1.22085665
36TNK21.21866946
37ACVR1B1.19773663
38NUAK11.18041755
39BLK1.15404285
40HCK1.12303173
41FES1.07036228
42MAP2K71.05522243
43PIM11.05425009
44TGFBR21.04759363
45MAP3K111.00503233
46EPHB10.99628126
47MAP2K60.98700071
48SYK0.96894577
49DMPK0.96808237
50SRPK10.94410070
51IRAK10.94109281
52IRAK30.93367834
53NEK90.92033865
54STK110.91467447
55MAP3K30.87809763
56HIPK20.86165830
57SIK30.84653364
58LYN0.84286226
59TAOK30.83816381
60MAPK110.82986849
61ADRBK20.79541086
62EPHA30.77253624
63PRKCH0.75425281
64BCR0.73092745
65IRAK20.71959499
66RET0.71943047
67MAPKAPK20.71046370
68CAMKK20.69867751
69MAP3K10.66756730
70RAF10.64572645
71SIK20.62388311
72CSF1R0.62169959
73FRK0.59431238
74TESK10.56182316
75RPS6KA40.55568392
76RPS6KA50.54349902
77JAK20.54041616
78IGF1R0.52621022
79CDK90.51838378
80MAP3K100.51538066
81IKBKB0.48121721
82FYN0.47520222
83MAP2K30.47330332
84CDK40.47287592
85PTK2B0.46630502
86MARK30.46630131
87INSR0.45421701
88LRRK20.42213300
89STK240.42055311
90FER0.41955583
91DAPK20.40990784
92TYRO30.40961665
93MELK0.40758165
94LIMK10.39344638
95NEK60.39222728
96BCKDK0.38669403
97FGR0.37741878
98NME20.37600352
99TTN0.35812341
100FGFR10.35212702
101EIF2AK10.35121235
102CSNK1G10.35058437
103VRK20.34331644
104DAPK10.33637004
105SGK30.33463862
106GRK50.31801330
107MAP3K130.30938655
108ALK0.29250471
109ATR0.29052827
110STK390.28296235
111KIT0.27676679
112YES10.27284541
113ABL10.24926038
114PRKCD0.24250264
115CSNK1G30.23150905
116MAPK150.22938745
117PDK10.22782171
118BUB10.22118363
119ERN10.22052315
120CAMK2A0.22051636
121CAMK2D0.21277918
122CSNK1A1L0.20387957
123PRKG20.19933481
124PRKD10.19846370
125SGK20.19582203
126PIK3CG0.19517443
127MYLK0.19320266
128PRKCE0.18453603
129MAP3K70.18124797
130BMPR20.17713466
131OXSR10.17409565
132MAPK120.16332055
133CDK60.16185370
134PDGFRB0.15276320
135EIF2AK20.14078631
136CHUK0.12732914
137CSNK1A10.12438393
138CSNK1G20.12210537

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053328.17318799
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.68289349
3Allograft rejection_Homo sapiens_hsa053304.38973240
4Primary immunodeficiency_Homo sapiens_hsa053404.07766038
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.23315165
6* Antigen processing and presentation_Homo sapiens_hsa046123.21796665
7Autoimmune thyroid disease_Homo sapiens_hsa053203.10095764
8T cell receptor signaling pathway_Homo sapiens_hsa046602.85478720
9Viral myocarditis_Homo sapiens_hsa054162.72377676
10Type I diabetes mellitus_Homo sapiens_hsa049402.62119471
11Proteasome_Homo sapiens_hsa030502.56828109
12Measles_Homo sapiens_hsa051622.40374809
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.28311186
14Leishmaniasis_Homo sapiens_hsa051401.56677506
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.54081712
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.44938162
17Hematopoietic cell lineage_Homo sapiens_hsa046401.44866387
18Malaria_Homo sapiens_hsa051441.38157041
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.36108407
20B cell receptor signaling pathway_Homo sapiens_hsa046621.29637011
21Osteoclast differentiation_Homo sapiens_hsa043801.29045254
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20397786
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20151484
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19247754
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18822715
26Chemokine signaling pathway_Homo sapiens_hsa040621.12315895
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02952813
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01925081
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01882659
30Toxoplasmosis_Homo sapiens_hsa051451.00481738
31Staphylococcus aureus infection_Homo sapiens_hsa051500.97431468
32Protein export_Homo sapiens_hsa030600.95864660
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95511315
34Herpes simplex infection_Homo sapiens_hsa051680.93645673
35Nitrogen metabolism_Homo sapiens_hsa009100.92251872
36Apoptosis_Homo sapiens_hsa042100.92179344
37Colorectal cancer_Homo sapiens_hsa052100.86144731
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85218775
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83600151
40Acute myeloid leukemia_Homo sapiens_hsa052210.82938445
41NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78037455
42Hepatitis B_Homo sapiens_hsa051610.77305170
43Shigellosis_Homo sapiens_hsa051310.75636182
44Ribosome_Homo sapiens_hsa030100.75543211
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74391321
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72916217
47Pancreatic cancer_Homo sapiens_hsa052120.71464786
48Influenza A_Homo sapiens_hsa051640.71236654
49VEGF signaling pathway_Homo sapiens_hsa043700.71083715
50HTLV-I infection_Homo sapiens_hsa051660.70039141
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66261544
52Linoleic acid metabolism_Homo sapiens_hsa005910.66247989
53TNF signaling pathway_Homo sapiens_hsa046680.65456268
54RNA polymerase_Homo sapiens_hsa030200.65121356
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64016259
56Platelet activation_Homo sapiens_hsa046110.61155037
57Legionellosis_Homo sapiens_hsa051340.60992916
58Rheumatoid arthritis_Homo sapiens_hsa053230.58765701
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57352442
60Epstein-Barr virus infection_Homo sapiens_hsa051690.56625410
61Oxidative phosphorylation_Homo sapiens_hsa001900.56567601
62Adherens junction_Homo sapiens_hsa045200.54630184
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54520844
64Fatty acid elongation_Homo sapiens_hsa000620.54135572
65Endocytosis_Homo sapiens_hsa041440.50118913
66Parkinsons disease_Homo sapiens_hsa050120.49853013
67Galactose metabolism_Homo sapiens_hsa000520.48098866
68Thyroid cancer_Homo sapiens_hsa052160.47659223
69Salmonella infection_Homo sapiens_hsa051320.46642433
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46380608
71Basal transcription factors_Homo sapiens_hsa030220.45910258
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45464287
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45069111
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44337916
75Tuberculosis_Homo sapiens_hsa051520.44138344
76Hepatitis C_Homo sapiens_hsa051600.43287606
77Pertussis_Homo sapiens_hsa051330.42428777
78p53 signaling pathway_Homo sapiens_hsa041150.42125804
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41607714
80Homologous recombination_Homo sapiens_hsa034400.41065867
81Spliceosome_Homo sapiens_hsa030400.39863250
82African trypanosomiasis_Homo sapiens_hsa051430.38813110
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34637160
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.31288988
85Chronic myeloid leukemia_Homo sapiens_hsa052200.30636455
86Small cell lung cancer_Homo sapiens_hsa052220.28994556
87Fatty acid biosynthesis_Homo sapiens_hsa000610.27853477
88Prolactin signaling pathway_Homo sapiens_hsa049170.27620209
89Viral carcinogenesis_Homo sapiens_hsa052030.27218742
90Choline metabolism in cancer_Homo sapiens_hsa052310.27092067
91Other glycan degradation_Homo sapiens_hsa005110.25735533
92Olfactory transduction_Homo sapiens_hsa047400.25640992
93Alzheimers disease_Homo sapiens_hsa050100.25076626
94DNA replication_Homo sapiens_hsa030300.24600351
95Focal adhesion_Homo sapiens_hsa045100.24243283
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22840649
97Circadian rhythm_Homo sapiens_hsa047100.22791375
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22575999
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22439387
100Endometrial cancer_Homo sapiens_hsa052130.22054586
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21627647
102Collecting duct acid secretion_Homo sapiens_hsa049660.21306800
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.21292643
104Rap1 signaling pathway_Homo sapiens_hsa040150.20725752
105Non-small cell lung cancer_Homo sapiens_hsa052230.20101420
106Renal cell carcinoma_Homo sapiens_hsa052110.20094907
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19930847
108Pentose phosphate pathway_Homo sapiens_hsa000300.19895950
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19424878
110Phototransduction_Homo sapiens_hsa047440.19391163
111Asthma_Homo sapiens_hsa053100.19098940
112RNA degradation_Homo sapiens_hsa030180.19069967
113FoxO signaling pathway_Homo sapiens_hsa040680.16437501
114Morphine addiction_Homo sapiens_hsa050320.15749299
115Inositol phosphate metabolism_Homo sapiens_hsa005620.15377487
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.15005102
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15002823
118Fanconi anemia pathway_Homo sapiens_hsa034600.14363579
119Regulation of autophagy_Homo sapiens_hsa041400.12786440
120Prion diseases_Homo sapiens_hsa050200.12649468
121Prostate cancer_Homo sapiens_hsa052150.12329320
122Butanoate metabolism_Homo sapiens_hsa006500.11396983
123Renin-angiotensin system_Homo sapiens_hsa046140.10748628
124MAPK signaling pathway_Homo sapiens_hsa040100.10559451
125Lysosome_Homo sapiens_hsa041420.10295905
126Nucleotide excision repair_Homo sapiens_hsa034200.07812467
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07442584
128N-Glycan biosynthesis_Homo sapiens_hsa005100.07076002
129Pathways in cancer_Homo sapiens_hsa052000.07060191
130HIF-1 signaling pathway_Homo sapiens_hsa040660.06087681
131GABAergic synapse_Homo sapiens_hsa047270.05685042
132Pyrimidine metabolism_Homo sapiens_hsa002400.05094193
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.04701097
134Base excision repair_Homo sapiens_hsa034100.04540366
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.04466010
136Ether lipid metabolism_Homo sapiens_hsa005650.04287702
137Mineral absorption_Homo sapiens_hsa049780.03957057
138Caffeine metabolism_Homo sapiens_hsa002320.03853528
139mRNA surveillance pathway_Homo sapiens_hsa030150.02646731
140Amoebiasis_Homo sapiens_hsa051460.01415249
141Mismatch repair_Homo sapiens_hsa03430-0.0239332

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