KLRC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)9.56236485
2interferon-gamma production (GO:0032609)8.87499249
3cytidine metabolic process (GO:0046087)8.71551214
4cytidine catabolic process (GO:0006216)8.71551214
5cytidine deamination (GO:0009972)8.71551214
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.09183911
7positive thymic T cell selection (GO:0045059)7.96994002
8negative T cell selection (GO:0043383)7.85273270
9cellular response to interleukin-15 (GO:0071350)7.81862621
10negative thymic T cell selection (GO:0045060)7.78581899
11positive regulation of gamma-delta T cell activation (GO:0046645)7.63200318
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.61592592
13T cell migration (GO:0072678)7.28741476
14regulation of natural killer cell mediated immunity (GO:0002715)7.28394223
15regulation of natural killer cell mediated cytotoxicity (GO:0042269)7.28394223
16DNA deamination (GO:0045006)6.87249016
17response to interleukin-15 (GO:0070672)6.76628102
18positive regulation of isotype switching (GO:0045830)6.70541921
19positive T cell selection (GO:0043368)6.69189851
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.45057250
21positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.39953696
22positive regulation of natural killer cell mediated immunity (GO:0002717)6.39953696
23regulation of gamma-delta T cell differentiation (GO:0045586)6.38896533
24thymic T cell selection (GO:0045061)6.22333131
25positive regulation of DNA recombination (GO:0045911)6.12545558
26regulation of leukocyte mediated cytotoxicity (GO:0001910)5.99057141
27negative regulation of T cell mediated immunity (GO:0002710)5.87748918
28regulation of B cell receptor signaling pathway (GO:0050855)5.85547210
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.74016700
30positive regulation of T cell cytokine production (GO:0002726)5.68835461
31regulation of cell killing (GO:0031341)5.64821042
32regulation of gamma-delta T cell activation (GO:0046643)5.64552393
33positive regulation of B cell mediated immunity (GO:0002714)5.61837185
34positive regulation of immunoglobulin mediated immune response (GO:0002891)5.61837185
35positive regulation of cell killing (GO:0031343)5.58523188
36leukocyte aggregation (GO:0070486)5.44735650
37positive regulation of alpha-beta T cell proliferation (GO:0046641)5.22807945
38negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)5.13537345
39T cell selection (GO:0045058)5.07722259
40regulation of isotype switching (GO:0045191)5.06778167
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.02682239
42positive regulation of defense response to virus by host (GO:0002230)4.99556258
43cytolysis (GO:0019835)4.97098476
44regulation of alpha-beta T cell proliferation (GO:0046640)4.84508339
45lymphocyte migration (GO:0072676)4.77649779
46activated T cell proliferation (GO:0050798)4.67044447
47regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.65843880
48regulation of T cell mediated cytotoxicity (GO:0001914)4.65682522
49positive regulation of T cell mediated cytotoxicity (GO:0001916)4.61407346
50sequestering of actin monomers (GO:0042989)4.55248548
51regulation of immunoglobulin mediated immune response (GO:0002889)4.54319754
52T cell receptor signaling pathway (GO:0050852)4.53108972
53natural killer cell activation (GO:0030101)4.46108492
54positive regulation of immunoglobulin production (GO:0002639)4.40926094
55regulation of B cell mediated immunity (GO:0002712)4.38688989
56regulation of T cell receptor signaling pathway (GO:0050856)4.34309487
57T cell costimulation (GO:0031295)4.27588754
58positive regulation of lymphocyte mediated immunity (GO:0002708)4.27209825
59positive regulation of lymphocyte migration (GO:2000403)4.22598508
60negative regulation of lymphocyte mediated immunity (GO:0002707)4.22429995
61positive regulation of humoral immune response (GO:0002922)4.20824649
62heterotypic cell-cell adhesion (GO:0034113)4.20810252
63lymphocyte costimulation (GO:0031294)4.17515973
64regulation of lymphocyte mediated immunity (GO:0002706)4.16438200
65pyrimidine nucleoside catabolic process (GO:0046135)4.07253442
66positive regulation of calcium-mediated signaling (GO:0050850)4.03765368
67response to interferon-beta (GO:0035456)4.02419721
68regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.99472533
69cellular response to interferon-beta (GO:0035458)3.97954935
70* cellular defense response (GO:0006968)3.96450251
71negative regulation by host of viral transcription (GO:0043922)3.95821665
72positive regulation of T cell mediated immunity (GO:0002711)3.95764441
73regulation of T cell cytokine production (GO:0002724)3.82849747
74antigen receptor-mediated signaling pathway (GO:0050851)3.82024867
75negative regulation of alpha-beta T cell activation (GO:0046636)3.80998332
76leukocyte cell-cell adhesion (GO:0007159)3.78461757
77alpha-beta T cell differentiation involved in immune response (GO:0002293)3.77881078
78alpha-beta T cell activation involved in immune response (GO:0002287)3.77881078
79T cell differentiation involved in immune response (GO:0002292)3.77881078
80regulation of immunoglobulin production (GO:0002637)3.76886156
81regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.75395302
82regulation of T-helper 1 type immune response (GO:0002825)3.73926689
83regulation of regulatory T cell differentiation (GO:0045589)3.70873578
84positive regulation of leukocyte mediated immunity (GO:0002705)3.70267481
85cellular extravasation (GO:0045123)3.68024302
86negative regulation of viral genome replication (GO:0045071)3.59485783
87negative regulation of execution phase of apoptosis (GO:1900118)3.56728646
88regulation of response to interferon-gamma (GO:0060330)3.56646338
89regulation of hypersensitivity (GO:0002883)3.54013275
90regulation of memory T cell differentiation (GO:0043380)3.52980151
91regulation of T cell chemotaxis (GO:0010819)3.50200730
92positive regulation of T cell chemotaxis (GO:0010820)3.50200730
93regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.49540095
94regulation of T cell mediated immunity (GO:0002709)3.48806078
95positive regulation of T-helper 1 type immune response (GO:0002827)3.47774751
96negative regulation of adaptive immune response (GO:0002820)3.47754937
97regulation of lymphocyte chemotaxis (GO:1901623)3.44688495
98positive regulation of type 2 immune response (GO:0002830)3.44056968
99negative regulation of metanephros development (GO:0072217)3.43812411
100cell wall macromolecule catabolic process (GO:0016998)3.42440524
101regulation of lymphocyte migration (GO:2000401)3.42192301
102T cell differentiation (GO:0030217)3.40063390
103antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39892437
104regulation of B cell differentiation (GO:0045577)3.36712874
105lymphocyte chemotaxis (GO:0048247)3.34232146
106positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.33262189
107positive regulation of lamellipodium assembly (GO:0010592)3.33020851
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32700563
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32700563
110antigen processing and presentation of endogenous antigen (GO:0019883)3.30614765
111regulation of leukocyte mediated immunity (GO:0002703)3.30603886
112negative regulation of interleukin-2 production (GO:0032703)3.30345894
113mast cell activation (GO:0045576)3.26825063
114positive regulation of interleukin-10 production (GO:0032733)3.25175749
115positive regulation of T cell migration (GO:2000406)3.24230164
116B cell receptor signaling pathway (GO:0050853)3.23167483
117positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.21999116
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21103187
119positive regulation of adaptive immune response (GO:0002821)3.19662736
120regulation of interleukin-12 biosynthetic process (GO:0045075)3.19219245
121negative regulation of leukocyte mediated immunity (GO:0002704)3.18702668
122regulation of activation of Janus kinase activity (GO:0010533)3.17372370
123alpha-beta T cell differentiation (GO:0046632)3.16216006
124negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.16018988
125regulation of RIG-I signaling pathway (GO:0039535)3.14869145
126negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.12763851
127antigen processing and presentation via MHC class Ib (GO:0002475)3.12536469
128alpha-beta T cell activation (GO:0046631)3.11981332
129positive regulation of interferon-gamma production (GO:0032729)3.09571015
130eosinophil chemotaxis (GO:0048245)3.09380320
131leukocyte degranulation (GO:0043299)3.09257066
132T cell activation (GO:0042110)3.09217022
133regulation of defense response to virus by host (GO:0050691)3.08333480
134T cell proliferation (GO:0042098)3.07409435
135negative regulation of T cell apoptotic process (GO:0070233)3.07018628
136regulation of T cell tolerance induction (GO:0002664)3.06583727
137negative regulation of T cell receptor signaling pathway (GO:0050860)3.00683107
138regulation of T cell migration (GO:2000404)3.00295824
139regulation of calcium-mediated signaling (GO:0050848)2.95317447
140regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92240036
141negative regulation of cell killing (GO:0031342)10.7090830
142negative regulation of leukocyte mediated cytotoxicity (GO:0001911)10.7090830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.51605329
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.84803879
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.26033862
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse5.09700923
5* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.46979765
6RUNX_20019798_ChIP-Seq_JUKART_Human4.43198794
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.05280047
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97937089
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.56894004
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.55902454
11MYB_26560356_Chip-Seq_TH2_Human3.24427525
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05141846
13MAF_26560356_Chip-Seq_TH1_Human2.98651139
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.92149770
15MYB_26560356_Chip-Seq_TH1_Human2.62794508
16UTX_26944678_Chip-Seq_JUKART_Human2.55879986
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.43384557
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17835041
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14884865
20GATA3_27048872_Chip-Seq_THYMUS_Human2.06701471
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04275657
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.98725501
23RUNX1_22412390_ChIP-Seq_EML_Mouse1.97788502
24MYC_22102868_ChIP-Seq_BL_Human1.91771784
25VDR_22108803_ChIP-Seq_LS180_Human1.85883805
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84933770
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78233000
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76599477
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.71294539
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70349272
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68019004
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66653491
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66368320
34SCL_19346495_ChIP-Seq_HPC-7_Human1.65664092
35GATA3_26560356_Chip-Seq_TH2_Human1.59239274
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58943661
37MAF_26560356_Chip-Seq_TH2_Human1.57276042
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56602083
39SPI1_23547873_ChIP-Seq_NB4_Human1.55902856
40VDR_23849224_ChIP-Seq_CD4+_Human1.49492105
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49116798
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45477525
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.44361066
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41560449
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41555176
46VDR_21846776_ChIP-Seq_THP-1_Human1.39204438
47VDR_24763502_ChIP-Seq_THP-1_Human1.38017980
48FOXP3_21729870_ChIP-Seq_TREG_Human1.36156253
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.27842196
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27656810
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26701230
52EGR1_19032775_ChIP-ChIP_M12_Human1.25840712
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25805144
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24578596
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23695973
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23386400
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23122231
58TCF7_22412390_ChIP-Seq_EML_Mouse1.23102282
59E2F7_22180533_ChIP-Seq_HELA_Human1.23093075
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.20605994
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.20590280
62PU_27001747_Chip-Seq_BMDM_Mouse1.16725266
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16547208
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16101792
65CIITA_25753668_ChIP-Seq_RAJI_Human1.15285022
66SPI1_23127762_ChIP-Seq_K562_Human1.14778591
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12476987
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.11547693
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10450176
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09976016
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09819142
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08459558
73* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02522963
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02019749
75GATA3_26560356_Chip-Seq_TH1_Human1.01398134
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00455774
77SRF_21415370_ChIP-Seq_HL-1_Mouse0.99551646
78KDM2B_26808549_Chip-Seq_DND41_Human0.99115301
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97715650
80KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95604341
81PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94765065
82VDR_24787735_ChIP-Seq_THP-1_Human0.93292224
83* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92190646
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92042498
85* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91606594
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89819158
87* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89369002
88CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88943654
89* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88589558
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88571371
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86733172
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86510115
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.85069818
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84555711
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84344372
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83579471
97IRF1_19129219_ChIP-ChIP_H3396_Human0.81846296
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.81390900
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81025418
100LXR_22292898_ChIP-Seq_THP-1_Human0.79371556
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79137168
102FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78091604
103FLI1_21867929_ChIP-Seq_CD8_Mouse0.77770970
104BCL6_27268052_Chip-Seq_Bcells_Human0.77676316
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76051313
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75475556
107FOXA1_25329375_ChIP-Seq_VCAP_Human0.74699114
108FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74699114
109* HTT_18923047_ChIP-ChIP_STHdh_Human0.74396667
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72664281
111NANOG_20526341_ChIP-Seq_ESCs_Human0.71978646
112HOXB4_20404135_ChIP-ChIP_EML_Mouse0.71521473
113AR_20517297_ChIP-Seq_VCAP_Human0.71347739
114P300_27268052_Chip-Seq_Bcells_Human0.71344827
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.71126755
116TP53_22573176_ChIP-Seq_HFKS_Human0.71059890
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70276897
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69923066
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.69781007
120NMYC_18555785_Chip-Seq_ESCs_Mouse0.68593957
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67051191
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67006816
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.66635440
124CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64705186
125IKZF1_21737484_ChIP-ChIP_HCT116_Human0.64468433
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.61573064
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61568653
128SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61468610
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.60527390
130GATA2_19941826_ChIP-Seq_K562_Human0.60435859
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59679759
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58569405
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.55600772
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.55190605
135ESRRB_18555785_Chip-Seq_ESCs_Mouse0.55149224
136PU1_27457419_Chip-Seq_LIVER_Mouse0.54445894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.61180621
2MP0006082_CNS_inflammation5.10799401
3MP0003763_abnormal_thymus_physiology4.80501927
4MP0009785_altered_susceptibility_to4.24976889
5MP0001800_abnormal_humoral_immune3.19005020
6MP0001835_abnormal_antigen_presentation3.10053712
7MP0005025_abnormal_response_to3.08530316
8MP0001873_stomach_inflammation2.97779004
9MP0005000_abnormal_immune_tolerance2.90109902
10MP0002420_abnormal_adaptive_immunity2.83900272
11MP0001819_abnormal_immune_cell2.83099171
12MP0002723_abnormal_immune_serum2.78839468
13MP0002405_respiratory_system_inflammati2.71899725
14MP0003448_altered_tumor_morphology2.62552338
15MP0000685_abnormal_immune_system2.58983028
16MP0001790_abnormal_immune_system2.57706634
17MP0005387_immune_system_phenotype2.57706634
18MP0009333_abnormal_splenocyte_physiolog2.52541378
19MP0002006_tumorigenesis2.50511198
20MP0004947_skin_inflammation2.49129751
21MP0002452_abnormal_antigen_presenting2.47263676
22MP0000858_altered_metastatic_potential2.46882672
23MP0002166_altered_tumor_susceptibility2.43659864
24MP0002398_abnormal_bone_marrow2.38920826
25MP0002132_abnormal_respiratory_system2.36253981
26MP0003950_abnormal_plasma_membrane2.23650304
27MP0000716_abnormal_immune_system2.19137380
28MP0000569_abnormal_digit_pigmentation2.17103646
29MP0010234_abnormal_vibrissa_follicle2.07712228
30MP0002722_abnormal_immune_system2.05812855
31MP0000703_abnormal_thymus_morphology2.05310883
32MP0001986_abnormal_taste_sensitivity2.03138744
33MP0002419_abnormal_innate_immunity2.01661099
34MP0000689_abnormal_spleen_morphology1.98772150
35MP0003045_fibrosis1.94757344
36MP0003724_increased_susceptibility_to1.94539927
37MP0004381_abnormal_hair_follicle1.90047910
38MP0010155_abnormal_intestine_physiology1.87002309
39MP0002148_abnormal_hypersensitivity_rea1.84873042
40MP0002998_abnormal_bone_remodeling1.76546297
41MP0002429_abnormal_blood_cell1.68333397
42MP0001845_abnormal_inflammatory_respons1.63117362
43MP0002933_joint_inflammation1.51596214
44MP0003436_decreased_susceptibility_to1.51069408
45MP0003786_premature_aging1.49419525
46MP0008469_abnormal_protein_level1.40537554
47MP0002163_abnormal_gland_morphology1.40234273
48MP0003866_abnormal_defecation1.35912231
49MP0000372_irregular_coat_pigmentation1.35620167
50MP0002009_preneoplasia1.34336837
51MP0001851_eye_inflammation1.30956496
52MP0000613_abnormal_salivary_gland1.28827875
53MP0005464_abnormal_platelet_physiology1.26090010
54MP0010307_abnormal_tumor_latency1.25080948
55MP0000920_abnormal_myelination1.19856893
56MP0005166_decreased_susceptibility_to1.17879844
57MP0002019_abnormal_tumor_incidence1.16056257
58MP0003453_abnormal_keratinocyte_physiol1.06698267
59MP0002396_abnormal_hematopoietic_system1.05682855
60MP0003300_gastrointestinal_ulcer1.05370492
61MP0002877_abnormal_melanocyte_morpholog1.04172909
62MP0005451_abnormal_body_composition1.01654355
63MP0002876_abnormal_thyroid_physiology0.92575652
64MP0003183_abnormal_peptide_metabolism0.90447255
65MP0009763_increased_sensitivity_to0.89797204
66MP0001533_abnormal_skeleton_physiology0.87199728
67MP0003172_abnormal_lysosome_physiology0.86990729
68MP0004510_myositis0.85395130
69MP0008057_abnormal_DNA_replication0.84888076
70MP0008877_abnormal_DNA_methylation0.79102902
71MP0005174_abnormal_tail_pigmentation0.76533824
72MP0002136_abnormal_kidney_physiology0.76311974
73MP0005023_abnormal_wound_healing0.75586088
74MP0000490_abnormal_crypts_of0.75218797
75MP0005310_abnormal_salivary_gland0.73204667
76MP0001853_heart_inflammation0.72683620
77MP0003878_abnormal_ear_physiology0.71652616
78MP0005377_hearing/vestibular/ear_phenot0.71652616
79MP0005167_abnormal_blood-brain_barrier0.71617701
80MP0002736_abnormal_nociception_after0.70996747
81MP0000343_altered_response_to0.70995952
82MP0001191_abnormal_skin_condition0.70982488
83MP0009764_decreased_sensitivity_to0.70380472
84MP0008569_lethality_at_weaning0.69467701
85MP0001881_abnormal_mammary_gland0.69419454
86MP0005408_hypopigmentation0.67214927
87MP0002837_dystrophic_cardiac_calcinosis0.64553974
88MP0002277_abnormal_respiratory_mucosa0.64110555
89MP0000609_abnormal_liver_physiology0.63925825
90MP0001348_abnormal_lacrimal_gland0.62512816
91MP0005075_abnormal_melanosome_morpholog0.62252204
92MP0005165_increased_susceptibility_to0.61965413
93MP0001661_extended_life_span0.61343090
94MP0005501_abnormal_skin_physiology0.60941308
95MP0005423_abnormal_somatic_nervous0.60730868
96MP0004742_abnormal_vestibular_system0.60723887
97MP0005360_urolithiasis0.60021527
98MP0001216_abnormal_epidermal_layer0.59953817
99MP0006035_abnormal_mitochondrial_morpho0.59081490
100MP0009643_abnormal_urine_homeostasis0.58706635
101MP0002693_abnormal_pancreas_physiology0.56339176
102MP0009765_abnormal_xenobiotic_induced0.55795908
103MP0001968_abnormal_touch/_nociception0.53470266
104MP0003795_abnormal_bone_structure0.53216780
105MP0004147_increased_porphyrin_level0.52730950
106MP0008872_abnormal_physiological_respon0.52064369
107MP0005409_darkened_coat_color0.52042047
108MP0003566_abnormal_cell_adhesion0.50253978
109MP0006072_abnormal_retinal_apoptosis0.48496778
110MP0001765_abnormal_ion_homeostasis0.47799840
111MP0003959_abnormal_lean_body0.46689434
112MP0000465_gastrointestinal_hemorrhage0.45762785
113MP0003646_muscle_fatigue0.45583324
114MP0001501_abnormal_sleep_pattern0.45456632
115MP0000427_abnormal_hair_cycle0.44557459
116MP0002138_abnormal_hepatobiliary_system0.44044855
117MP0005636_abnormal_mineral_homeostasis0.43838214
118MP0002060_abnormal_skin_morphology0.43274474
119MP0003303_peritoneal_inflammation0.43195077
120MP0001919_abnormal_reproductive_system0.43173572
121MP0008007_abnormal_cellular_replicative0.42938868
122MP0002168_other_aberrant_phenotype0.42392234
123MP0000477_abnormal_intestine_morphology0.42321898
124MP0002089_abnormal_postnatal_growth/wei0.41600154
125MP0001542_abnormal_bone_strength0.40592838
126MP0000627_abnormal_mammary_gland0.39754792
127MP0000015_abnormal_ear_pigmentation0.39649472
128MP0009379_abnormal_foot_pigmentation0.39607814
129MP0000367_abnormal_coat/_hair0.39320709
130MP0001243_abnormal_dermal_layer0.39135194
131MP0003136_yellow_coat_color0.35084102
132MP0005584_abnormal_enzyme/coenzyme_acti0.34304298
133MP0008873_increased_physiological_sensi0.33862193
134MP0005319_abnormal_enzyme/_coenzyme0.33715094

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.97062318
2Abnormality of T cell number (HP:0011839)7.65592155
3Optic neuritis (HP:0100653)7.31429650
4Retrobulbar optic neuritis (HP:0100654)7.31429650
5Severe combined immunodeficiency (HP:0004430)6.70374501
6Myositis (HP:0100614)6.51596053
7Orchitis (HP:0100796)6.32413805
8Combined immunodeficiency (HP:0005387)5.91975228
9Keratoconjunctivitis sicca (HP:0001097)5.27311511
10Keratoconjunctivitis (HP:0001096)4.77082697
11Thyroiditis (HP:0100646)4.77055561
12Encephalitis (HP:0002383)4.65700336
13Abnormality of T cells (HP:0002843)4.43478067
14Chronic mucocutaneous candidiasis (HP:0002728)4.41627462
15Recurrent cutaneous fungal infections (HP:0011370)4.41627462
16Autoimmune hemolytic anemia (HP:0001890)4.25257895
17Hypoplasia of the thymus (HP:0000778)4.15805865
18Nasal polyposis (HP:0100582)4.03268125
19Joint swelling (HP:0001386)4.02578988
20Recurrent bronchitis (HP:0002837)3.95215771
21Meningitis (HP:0001287)3.93310790
22Abnormality of T cell physiology (HP:0011840)3.87281712
23Granulocytopenia (HP:0001913)3.83431802
24Stomatitis (HP:0010280)3.82337645
25Chronic diarrhea (HP:0002028)3.74489588
26Hypoproteinemia (HP:0003075)3.71430774
27Increased IgM level (HP:0003496)3.70446330
28IgG deficiency (HP:0004315)3.69571387
29Eczematoid dermatitis (HP:0000976)3.63229849
30Abnormality of eosinophils (HP:0001879)3.63005542
31Recurrent fungal infections (HP:0002841)3.58297742
32Hemoptysis (HP:0002105)3.56781053
33Arterial thrombosis (HP:0004420)3.48058057
34Elevated erythrocyte sedimentation rate (HP:0003565)3.44312652
35Gangrene (HP:0100758)3.43703882
36Agammaglobulinemia (HP:0004432)3.35794017
37Pulmonary embolism (HP:0002204)3.24498331
38Pulmonary infiltrates (HP:0002113)3.23678004
39Abnormality of the nasal mucosa (HP:0000433)3.23574834
40Autoimmune thrombocytopenia (HP:0001973)3.14315427
41Cutaneous melanoma (HP:0012056)3.03820747
42Leukocytosis (HP:0001974)2.98020152
43Vasculitis (HP:0002633)2.95526804
44Renal cortical cysts (HP:0000803)2.86449228
45Hemiplegia (HP:0002301)2.86313531
46Recurrent abscess formation (HP:0002722)2.85689911
47Panhypogammaglobulinemia (HP:0003139)2.83858661
48IgM deficiency (HP:0002850)2.73697501
49Anorexia (HP:0002039)2.70680660
50Recurrent skin infections (HP:0001581)2.67363919
51Mediastinal lymphadenopathy (HP:0100721)2.59087433
52Keratitis (HP:0000491)2.52618248
53Abnormality of the common coagulation pathway (HP:0010990)2.48417952
54Pustule (HP:0200039)2.47565199
55Recurrent sinusitis (HP:0011108)2.45859530
56Obstructive lung disease (HP:0006536)2.43134329
57Chronic obstructive pulmonary disease (HP:0006510)2.43134329
583-Methylglutaconic aciduria (HP:0003535)2.40340029
59Recurrent viral infections (HP:0004429)2.39865439
60Abnormality of macrophages (HP:0004311)2.37057354
61Abnormality of the prostate (HP:0008775)2.33079196
62Chronic otitis media (HP:0000389)2.31477578
63Lymphopenia (HP:0001888)2.28759668
64Increased IgE level (HP:0003212)2.27675605
65Lymphoma (HP:0002665)2.27492028
66Aplastic anemia (HP:0001915)2.26941552
67Glomerulopathy (HP:0100820)2.26077812
68Polyneuropathy (HP:0001271)2.24567577
69Gastrointestinal infarctions (HP:0005244)2.24325495
70Abnormality of secondary sexual hair (HP:0009888)2.23612221
71Abnormality of the axillary hair (HP:0100134)2.23612221
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.17861516
73Bronchitis (HP:0012387)2.17277041
74Abnormality of the fingertips (HP:0001211)2.16332592
75Colitis (HP:0002583)2.14736812
76Abnormality of the pleura (HP:0002103)2.13780652
77Carpal bone hypoplasia (HP:0001498)2.13062910
78Tetraplegia (HP:0002445)2.10538503
79Abnormality of the pericardium (HP:0001697)2.07725777
80Inflammation of the large intestine (HP:0002037)2.05714629
81Microcytic anemia (HP:0001935)2.02930979
82Hypoalbuminemia (HP:0003073)2.01530801
83Abnormal albumin level (HP:0012116)2.01530801
84Eosinophilia (HP:0001880)2.00651218
85Hypergammaglobulinemia (HP:0010702)2.00510090
86Increased serum ferritin (HP:0003281)2.00105656
87Thrombophlebitis (HP:0004418)1.96742692
88Ureteral stenosis (HP:0000071)1.93245154
89Alveolar cell carcinoma (HP:0006519)1.93004754
90Abnormality of iron homeostasis (HP:0011031)1.92419474
91Porencephaly (HP:0002132)1.92323448
92Gastrointestinal inflammation (HP:0004386)1.91513379
93Arthropathy (HP:0003040)1.91231037
94Recurrent otitis media (HP:0000403)1.89637166
95Gingivitis (HP:0000230)1.89624751
96Abnormality of the endocardium (HP:0004306)1.88802695
97Arthralgia (HP:0002829)1.88749757
98Squamous cell carcinoma (HP:0002860)1.85543798
99IgA deficiency (HP:0002720)1.84883297
100Sepsis (HP:0100806)1.83270513
101Acne (HP:0001061)1.82670998
102Abnormal platelet volume (HP:0011876)1.79533451
103Abnormal delayed hypersensitivity skin test (HP:0002963)1.78090785
104Fair hair (HP:0002286)1.77913069
105Conical tooth (HP:0000698)1.77526971
106Progressive inability to walk (HP:0002505)1.77134247
107Skin rash (HP:0000988)1.73344915
108Spontaneous hematomas (HP:0007420)1.73316435
109Prolonged neonatal jaundice (HP:0006579)1.71844401
110Recurrent bacterial skin infections (HP:0005406)1.71515802
111Dry hair (HP:0011359)1.71214260
112Anhidrosis (HP:0000970)1.71100185
113Duplicated collecting system (HP:0000081)1.71005521
114Congenital stationary night blindness (HP:0007642)1.70668616
115Diplopia (HP:0000651)1.70529774
116Abnormality of binocular vision (HP:0011514)1.70529774
117Congenital, generalized hypertrichosis (HP:0004540)1.70403105
118Vertigo (HP:0002321)1.70245929
119Abnormality of oral frenula (HP:0000190)1.70165393
120Thrombocytosis (HP:0001894)1.69977414
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.69769786
122Lower limb hyperreflexia (HP:0002395)1.69264113
123Basal ganglia calcification (HP:0002135)1.68877432
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66915818
125Hepatosplenomegaly (HP:0001433)1.66770233
126Pancreatic cysts (HP:0001737)1.66081324
127Neoplasm of the tracheobronchial system (HP:0100552)1.65690748
128Ureteral obstruction (HP:0006000)1.64641438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.54438330
2MAP3K123.87144559
3MAP4K13.78425306
4ITK3.62360594
5FGFR43.17261936
6JAK12.93801488
7CSK2.67491364
8TYK22.63592478
9JAK32.50814310
10ZAP702.42448228
11SRPK12.41038524
12IKBKE2.22927204
13MAP2K62.13423473
14MAP3K142.02735224
15FGFR31.91382905
16BLK1.89841830
17TGFBR21.77596118
18LCK1.72896462
19KIT1.67749397
20MAP3K111.60757905
21KDR1.59341619
22GRK71.55223370
23TNK21.52958034
24TBK11.52755555
25STK101.51079360
26DAPK21.48465018
27NEK91.46527951
28IRAK41.45929876
29ADRBK21.44433093
30NUAK11.43391691
31CDK31.42141872
32MAP2K31.37657221
33MAP3K31.29387731
34PRKCH1.27271462
35MST41.24485805
36MAPKAPK31.24322962
37IRAK11.12487639
38MATK1.12144818
39SYK1.11695944
40BCR1.06693666
41CLK11.06029215
42MYLK1.04229417
43BTK1.01475987
44PRKCQ1.00459711
45HCK0.96508830
46EPHB10.95952063
47NLK0.94234324
48SIK30.92286984
49GRK50.91654966
50MAP3K70.90582117
51LYN0.89168073
52NTRK10.89146632
53TLK10.89041964
54MAP3K130.88719341
55MOS0.88700987
56WNK40.88457381
57GRK60.86493227
58PIK3CA0.83388478
59FER0.81658672
60TESK20.80917031
61PIK3CG0.80795320
62IRAK30.79763670
63SIK20.79683368
64EIF2AK20.77246678
65STK390.74500598
66MAPKAPK20.73742438
67TEC0.73581021
68NME20.72400398
69TAOK10.72201823
70FYN0.68729526
71TAOK20.68359731
72JAK20.68159003
73FES0.64965733
74MAP3K10.64277188
75NEK20.63329666
76BUB10.62950590
77CAMKK20.61449060
78IGF1R0.60589363
79ALK0.59788521
80CHUK0.59406390
81CASK0.58519332
82CDK40.58314297
83TTN0.58003423
84EPHA30.56947210
85PIM10.56735929
86MAP3K100.53842252
87CSF1R0.52301711
88FGFR10.52108264
89RIPK40.50403914
90RPS6KA50.49416664
91MAPK130.48653175
92MELK0.48562361
93MAPK110.47514814
94SIK10.44066523
95MARK20.42666874
96CDK80.42367439
97INSR0.42221684
98ILK0.41317769
99IKBKB0.41000919
100HIPK20.40507186
101CSNK1A1L0.40323813
102MST1R0.38593991
103CSNK1A10.38484060
104DAPK30.38384142
105EIF2AK30.37064959
106MAP2K70.36775946
107PAK40.35899846
108MARK30.35034173
109INSRR0.33999292
110RET0.32811337
111PRKG20.32322083
112STK240.31259894
113LRRK20.30820478
114OXSR10.29429592
115CDC70.29236129
116CSNK1D0.29021518
117BRD40.28490081
118PRKD20.28217681
119TAOK30.27844927
120PRKCD0.27415482
121GSK3A0.24132008
122CDK90.24033681
123MAP2K20.22631488
124RPS6KA40.22595313
125DAPK10.21924437
126DMPK0.21778201
127ROCK20.21549299
128ACVR1B0.21523672
129CDK120.20733510
130RIPK10.20220226
131BMPR20.19931714
132ADRBK10.19723698
133ZAK0.19223169
134SRC0.18913515
135ATR0.18623406
136ABL10.18055363
137MAPK120.17939913
138CSNK1G10.17906871
139PRKCI0.17210507
140PDK10.16982625

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053329.77605312
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.78910430
3Primary immunodeficiency_Homo sapiens_hsa053404.40267062
4Allograft rejection_Homo sapiens_hsa053304.30300946
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.73462229
6* Antigen processing and presentation_Homo sapiens_hsa046123.48692260
7Autoimmune thyroid disease_Homo sapiens_hsa053202.71339601
8Type I diabetes mellitus_Homo sapiens_hsa049402.63673537
9T cell receptor signaling pathway_Homo sapiens_hsa046602.55030340
10Measles_Homo sapiens_hsa051622.07776983
11Viral myocarditis_Homo sapiens_hsa054161.94818825
12Proteasome_Homo sapiens_hsa030501.88840468
13Malaria_Homo sapiens_hsa051441.69401075
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67355883
15Hematopoietic cell lineage_Homo sapiens_hsa046401.63957185
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.51715670
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.50859260
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.47236326
19Leishmaniasis_Homo sapiens_hsa051401.38114280
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.35841467
21Staphylococcus aureus infection_Homo sapiens_hsa051501.24783421
22Osteoclast differentiation_Homo sapiens_hsa043801.24003500
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16222140
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11580781
25Chemokine signaling pathway_Homo sapiens_hsa040621.07657809
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02724732
27Caffeine metabolism_Homo sapiens_hsa002321.00534049
28B cell receptor signaling pathway_Homo sapiens_hsa046620.99668282
29Linoleic acid metabolism_Homo sapiens_hsa005910.95956010
30RNA polymerase_Homo sapiens_hsa030200.95474101
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93892827
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93049017
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91254016
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84052571
35Herpes simplex infection_Homo sapiens_hsa051680.82765029
36Toxoplasmosis_Homo sapiens_hsa051450.80851742
37Apoptosis_Homo sapiens_hsa042100.80755424
38Nitrogen metabolism_Homo sapiens_hsa009100.80020413
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74971833
40Hepatitis B_Homo sapiens_hsa051610.74518809
41Rheumatoid arthritis_Homo sapiens_hsa053230.65891781
42Pancreatic cancer_Homo sapiens_hsa052120.61898650
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61059405
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59635582
45Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58474897
46HTLV-I infection_Homo sapiens_hsa051660.57262406
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56091390
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52296516
49Platelet activation_Homo sapiens_hsa046110.52128367
50Asthma_Homo sapiens_hsa053100.50053197
51Protein export_Homo sapiens_hsa030600.49251992
52Ribosome_Homo sapiens_hsa030100.49132972
53Hepatitis C_Homo sapiens_hsa051600.46589945
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46284215
55TNF signaling pathway_Homo sapiens_hsa046680.45588527
56Legionellosis_Homo sapiens_hsa051340.45378459
57Other glycan degradation_Homo sapiens_hsa005110.45276551
58VEGF signaling pathway_Homo sapiens_hsa043700.43925804
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43036357
60Influenza A_Homo sapiens_hsa051640.42757874
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41170965
62Tuberculosis_Homo sapiens_hsa051520.40028223
63Colorectal cancer_Homo sapiens_hsa052100.37699051
64African trypanosomiasis_Homo sapiens_hsa051430.37407268
65Ether lipid metabolism_Homo sapiens_hsa005650.36178977
66Salmonella infection_Homo sapiens_hsa051320.31951970
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31738371
68Pertussis_Homo sapiens_hsa051330.31129002
69Phototransduction_Homo sapiens_hsa047440.31108529
70RNA degradation_Homo sapiens_hsa030180.30439425
71Epstein-Barr virus infection_Homo sapiens_hsa051690.29727116
72Shigellosis_Homo sapiens_hsa051310.29096800
73Chemical carcinogenesis_Homo sapiens_hsa052040.28870224
74Pyrimidine metabolism_Homo sapiens_hsa002400.25920991
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25516401
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23248173
77Rap1 signaling pathway_Homo sapiens_hsa040150.23087931
78Endocytosis_Homo sapiens_hsa041440.22937362
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21668556
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20182244
81Basal transcription factors_Homo sapiens_hsa030220.19957080
82Prolactin signaling pathway_Homo sapiens_hsa049170.18541819
83Spliceosome_Homo sapiens_hsa030400.18383776
84Lysosome_Homo sapiens_hsa041420.17994534
85Oxidative phosphorylation_Homo sapiens_hsa001900.17107101
86Viral carcinogenesis_Homo sapiens_hsa052030.16978590
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.16922099
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16080891
89Amoebiasis_Homo sapiens_hsa051460.15394311
90Acute myeloid leukemia_Homo sapiens_hsa052210.15067135
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14705456
92Homologous recombination_Homo sapiens_hsa034400.14293356
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.14017369
94Parkinsons disease_Homo sapiens_hsa050120.13480848
95HIF-1 signaling pathway_Homo sapiens_hsa040660.13173911
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.13128098
97Focal adhesion_Homo sapiens_hsa045100.13031786
98Olfactory transduction_Homo sapiens_hsa047400.12393823
99Small cell lung cancer_Homo sapiens_hsa052220.10391032
100One carbon pool by folate_Homo sapiens_hsa006700.10150006
101Purine metabolism_Homo sapiens_hsa002300.08941146
102Dorso-ventral axis formation_Homo sapiens_hsa043200.08768723
103Complement and coagulation cascades_Homo sapiens_hsa046100.08707799
104Renin secretion_Homo sapiens_hsa049240.08205094
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.07330692
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07219807
107Fanconi anemia pathway_Homo sapiens_hsa034600.07191868
108p53 signaling pathway_Homo sapiens_hsa041150.07120088
109Ras signaling pathway_Homo sapiens_hsa040140.07119272
110Chronic myeloid leukemia_Homo sapiens_hsa052200.05385681
111Collecting duct acid secretion_Homo sapiens_hsa049660.04898813
112Adherens junction_Homo sapiens_hsa045200.03275299
113ABC transporters_Homo sapiens_hsa020100.02770729
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.01626072
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01461482
116Regulation of autophagy_Homo sapiens_hsa041400.01274939
117Non-small cell lung cancer_Homo sapiens_hsa052230.00426775
118MAPK signaling pathway_Homo sapiens_hsa04010-0.0571407
119Dilated cardiomyopathy_Homo sapiens_hsa05414-0.0540590
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770-0.0495096
121cAMP signaling pathway_Homo sapiens_hsa04024-0.0429967
122Oxytocin signaling pathway_Homo sapiens_hsa04921-0.0422649
123Pathways in cancer_Homo sapiens_hsa05200-0.0389494
124Mismatch repair_Homo sapiens_hsa03430-0.0331915
125PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0306867
126Neurotrophin signaling pathway_Homo sapiens_hsa04722-0.0280786
127Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0236177
128FoxO signaling pathway_Homo sapiens_hsa04068-0.0221129
129cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0181333
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0157937
131Morphine addiction_Homo sapiens_hsa05032-0.0139317
132Sphingolipid metabolism_Homo sapiens_hsa00600-0.0133113
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0129724
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0007516

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