KLRC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)7.21147652
2cytidine deamination (GO:0009972)6.87389989
3cytidine metabolic process (GO:0046087)6.87389989
4cytidine catabolic process (GO:0006216)6.87389989
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.86473263
6negative regulation of cell killing (GO:0031342)6.86473263
7positive regulation of gamma-delta T cell activation (GO:0046645)6.55498448
8response to interleukin-15 (GO:0070672)6.52219459
9pyrimidine ribonucleoside catabolic process (GO:0046133)6.27512194
10regulation of gamma-delta T cell differentiation (GO:0045586)6.17310626
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.79754663
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.72597912
13negative T cell selection (GO:0043383)5.71300816
14interferon-gamma production (GO:0032609)5.63721481
15regulation of gamma-delta T cell activation (GO:0046643)5.59107144
16positive T cell selection (GO:0043368)5.50388711
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.41465198
18DNA deamination (GO:0045006)5.39536712
19positive regulation of natural killer cell mediated immunity (GO:0002717)5.35773425
20activated T cell proliferation (GO:0050798)5.31048090
21negative regulation of T cell mediated immunity (GO:0002710)5.29880016
22T cell migration (GO:0072678)5.28665543
23regulation of T cell chemotaxis (GO:0010819)5.22802792
24positive regulation of T cell chemotaxis (GO:0010820)5.22802792
25positive thymic T cell selection (GO:0045059)5.17095423
26regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.10161634
27regulation of natural killer cell mediated immunity (GO:0002715)5.10161634
28positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.09360863
29positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.07907114
30negative thymic T cell selection (GO:0045060)5.07619052
31regulation of B cell receptor signaling pathway (GO:0050855)4.92652501
32positive regulation of T cell mediated cytotoxicity (GO:0001916)4.89500280
33regulation of leukocyte mediated cytotoxicity (GO:0001910)4.78684235
34regulation of T cell mediated cytotoxicity (GO:0001914)4.71931716
35regulation of lymphocyte chemotaxis (GO:1901623)4.62685998
36positive regulation of cell killing (GO:0031343)4.62375175
37regulation of alpha-beta T cell proliferation (GO:0046640)4.57233725
38positive regulation of alpha-beta T cell proliferation (GO:0046641)4.50817705
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.50725629
40regulation of cell killing (GO:0031341)4.40366930
41thymic T cell selection (GO:0045061)4.31581137
42negative regulation of lymphocyte mediated immunity (GO:0002707)4.27287060
43T cell selection (GO:0045058)4.23261926
44regulation of activation of Janus kinase activity (GO:0010533)4.14857444
45antigen processing and presentation of endogenous antigen (GO:0019883)4.08377278
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.04551042
47regulation of regulatory T cell differentiation (GO:0045589)4.03117647
48regulation of B cell differentiation (GO:0045577)4.00783456
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91385479
50lymphocyte migration (GO:0072676)3.91275783
51positive regulation of defense response to virus by host (GO:0002230)3.89019070
52T cell mediated immunity (GO:0002456)3.87880300
53* cellular defense response (GO:0006968)3.86227007
54regulation of T cell tolerance induction (GO:0002664)3.83617853
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.77385073
56negative regulation of leukocyte mediated immunity (GO:0002704)3.76979359
57T cell receptor signaling pathway (GO:0050852)3.76175589
58lymphocyte chemotaxis (GO:0048247)3.74325501
59negative regulation of T cell apoptotic process (GO:0070233)3.74301519
60positive regulation of calcium-mediated signaling (GO:0050850)3.70307720
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.67412994
62positive regulation of tolerance induction (GO:0002645)3.62555062
63negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.59742077
64negative regulation of adaptive immune response (GO:0002820)3.58323902
65antigen processing and presentation via MHC class Ib (GO:0002475)3.56066981
66negative regulation of interleukin-12 production (GO:0032695)3.47916986
67positive regulation of granulocyte differentiation (GO:0030854)3.47511189
68positive regulation of lymphocyte migration (GO:2000403)3.46389430
69negative regulation of alpha-beta T cell activation (GO:0046636)3.44512581
70regulation of histone H3-K27 methylation (GO:0061085)3.44337508
71positive regulation of B cell differentiation (GO:0045579)3.44222825
72regulation of isotype switching to IgG isotypes (GO:0048302)3.44020254
73antigen receptor-mediated signaling pathway (GO:0050851)3.40432174
74positive regulation of T cell mediated immunity (GO:0002711)3.37494349
75mast cell activation (GO:0045576)3.34165862
76negative regulation by host of viral transcription (GO:0043922)3.30705236
77regulation of tolerance induction (GO:0002643)3.30103510
78natural killer cell activation (GO:0030101)3.26338237
79regulation of interleukin-12 biosynthetic process (GO:0045075)3.26113466
80negative regulation of viral genome replication (GO:0045071)3.25093500
81regulation of T cell receptor signaling pathway (GO:0050856)3.24826019
82positive regulation of lymphocyte mediated immunity (GO:0002708)3.23350256
83regulation of T cell mediated immunity (GO:0002709)3.12402496
84pyrimidine nucleoside catabolic process (GO:0046135)3.11918200
85leukocyte aggregation (GO:0070486)3.10405217
86positive regulation of T cell cytokine production (GO:0002726)3.05126623
87positive regulation of T cell migration (GO:2000406)3.04571680
88dendritic cell chemotaxis (GO:0002407)3.02434142
89Peyers patch development (GO:0048541)3.00513241
90mucosal-associated lymphoid tissue development (GO:0048537)3.00513241
91T cell costimulation (GO:0031295)3.00206566
92T cell differentiation (GO:0030217)2.98891324
93T-helper cell differentiation (GO:0042093)2.97707687
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.97707687
95regulation of alpha-beta T cell activation (GO:0046634)2.97249799
96alpha-beta T cell differentiation (GO:0046632)2.97247849
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.97055842
98positive regulation of humoral immune response (GO:0002922)2.96870968
99lymphocyte costimulation (GO:0031294)2.96130278
100regulation of lymphocyte mediated immunity (GO:0002706)2.96061017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.42029745
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.14150345
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.81903840
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.98617616
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.79370973
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.84719156
7RUNX_20019798_ChIP-Seq_JUKART_Human3.78030433
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.75599778
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.46751592
10MYB_26560356_Chip-Seq_TH2_Human3.35342584
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.05411164
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.80561017
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78222044
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71529178
15GATA3_27048872_Chip-Seq_THYMUS_Human2.44016830
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37733624
17MYB_26560356_Chip-Seq_TH1_Human2.37379281
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.28212720
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22162603
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.18153230
21GATA3_26560356_Chip-Seq_TH2_Human2.17989689
22MAF_26560356_Chip-Seq_TH1_Human2.16539805
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96320568
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.94259078
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84574246
26UTX_26944678_Chip-Seq_JUKART_Human1.82747771
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82373305
28SPI1_23547873_ChIP-Seq_NB4_Human1.81332939
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75974047
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74494518
31RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.65749577
32MAF_26560356_Chip-Seq_TH2_Human1.63785964
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58227684
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49082995
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47821455
36SCL_19346495_ChIP-Seq_HPC-7_Human1.46829420
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44394150
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38341989
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.36815037
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36305188
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30320944
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26812398
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25706146
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24266480
45TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21403210
46GATA3_26560356_Chip-Seq_TH1_Human1.20104622
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19882058
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18779641
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.15294828
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14299247
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12677511
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11510528
53VDR_24787735_ChIP-Seq_THP-1_Human1.10060041
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08576067
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08328516
56SPI1_23127762_ChIP-Seq_K562_Human1.08325729
57SMRT_27268052_Chip-Seq_Bcells_Human1.05934067
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04391915
59VDR_23849224_ChIP-Seq_CD4+_Human1.03260223
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00548989
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99384536
62GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98096697
63VDR_22108803_ChIP-Seq_LS180_Human0.97514438
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96393882
65NFE2_27457419_Chip-Seq_LIVER_Mouse0.95780432
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95555394
67PU_27001747_Chip-Seq_BMDM_Mouse0.95414026
68GATA1_22025678_ChIP-Seq_K562_Human0.94003779
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91510294
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90887784
71SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90866853
72* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90172580
73GATA1_19941827_ChIP-Seq_MEL_Mouse0.86918635
74HTT_18923047_ChIP-ChIP_STHdh_Human0.86896857
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84500907
76PRDM14_20953172_ChIP-Seq_ESCs_Human0.83572925
77RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82956809
78TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82941409
79GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82867833
80MYC_22102868_ChIP-Seq_BL_Human0.82139224
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.81736397
82CIITA_25753668_ChIP-Seq_RAJI_Human0.81378990
83FOXP3_21729870_ChIP-Seq_TREG_Human0.80108553
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79809263
85STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79588282
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.79472558
87HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78258635
88VDR_24763502_ChIP-Seq_THP-1_Human0.77839763
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76647317
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76350485
91P300_27268052_Chip-Seq_Bcells_Human0.76240586
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75263017
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75159845
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74376488
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.74182903
96BCL6_27268052_Chip-Seq_Bcells_Human0.73583245
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.71420902
98OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70079741
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.68983246
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66199784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.09996696
2MP0003763_abnormal_thymus_physiology4.65976193
3MP0001835_abnormal_antigen_presentation3.91143639
4MP0006082_CNS_inflammation3.38634810
5MP0001800_abnormal_humoral_immune3.22972351
6MP0005000_abnormal_immune_tolerance3.09041526
7MP0002723_abnormal_immune_serum2.92454253
8MP0005387_immune_system_phenotype2.91106446
9MP0001790_abnormal_immune_system2.91106446
10MP0009785_altered_susceptibility_to2.90142249
11MP0002420_abnormal_adaptive_immunity2.85770308
12MP0001819_abnormal_immune_cell2.79932303
13MP0009333_abnormal_splenocyte_physiolog2.76269650
14MP0004381_abnormal_hair_follicle2.69702140
15MP0005025_abnormal_response_to2.62603243
16MP0000685_abnormal_immune_system2.62298509
17MP0003436_decreased_susceptibility_to2.51877883
18MP0002452_abnormal_antigen_presenting2.50995324
19MP0003866_abnormal_defecation2.48370424
20MP0003724_increased_susceptibility_to2.48100687
21MP0002166_altered_tumor_susceptibility2.43070755
22MP0002148_abnormal_hypersensitivity_rea2.37664105
23MP0002398_abnormal_bone_marrow2.35705943
24MP0002419_abnormal_innate_immunity2.26550600
25MP0000716_abnormal_immune_system2.22878615
26MP0000703_abnormal_thymus_morphology2.18094777
27MP0002006_tumorigenesis2.11533727
28MP0002405_respiratory_system_inflammati2.05409734
29MP0010155_abnormal_intestine_physiology2.01414141
30MP0000689_abnormal_spleen_morphology1.99376023
31MP0002722_abnormal_immune_system1.95104082
32MP0003045_fibrosis1.87914888
33MP0005075_abnormal_melanosome_morpholog1.77205593
34MP0001853_heart_inflammation1.75114718
35MP0004947_skin_inflammation1.72409798
36MP0002429_abnormal_blood_cell1.70612985
37MP0001845_abnormal_inflammatory_respons1.64211378
38MP0000569_abnormal_digit_pigmentation1.59018152
39MP0005310_abnormal_salivary_gland1.49160520
40MP0002163_abnormal_gland_morphology1.44833635
41MP0003448_altered_tumor_morphology1.41217747
42MP0005464_abnormal_platelet_physiology1.37087275
43MP0008469_abnormal_protein_level1.34747319
44MP0005377_hearing/vestibular/ear_phenot1.34574087
45MP0003878_abnormal_ear_physiology1.34574087
46MP0003300_gastrointestinal_ulcer1.30823378
47MP0003786_premature_aging1.25933467
48MP0001873_stomach_inflammation1.16998949
49MP0009764_decreased_sensitivity_to1.13072658
50MP0000858_altered_metastatic_potential1.07840619
51MP0003183_abnormal_peptide_metabolism1.02166696
52MP0003646_muscle_fatigue1.01253095
53MP0001533_abnormal_skeleton_physiology0.97351770
54MP0009763_increased_sensitivity_to0.94878154
55MP0002998_abnormal_bone_remodeling0.94607597
56MP0008877_abnormal_DNA_methylation0.89133137
57MP0008873_increased_physiological_sensi0.88950427
58MP0002019_abnormal_tumor_incidence0.88299432
59MP0002933_joint_inflammation0.86746229
60MP0000920_abnormal_myelination0.84460724
61MP0002132_abnormal_respiratory_system0.80716482
62MP0005379_endocrine/exocrine_gland_phen0.79425829
63MP0008057_abnormal_DNA_replication0.78369853
64MP0002009_preneoplasia0.78243368
65MP0002277_abnormal_respiratory_mucosa0.78070566
66MP0002396_abnormal_hematopoietic_system0.76172492
67MP0004142_abnormal_muscle_tone0.74898245
68MP0005167_abnormal_blood-brain_barrier0.74772476
69MP0005174_abnormal_tail_pigmentation0.69946912
70MP0002693_abnormal_pancreas_physiology0.68228834
71MP0002837_dystrophic_cardiac_calcinosis0.65710292
72MP0004145_abnormal_muscle_electrophysio0.65207866
73MP0009765_abnormal_xenobiotic_induced0.64929975
74MP0000013_abnormal_adipose_tissue0.63554583
75MP0001986_abnormal_taste_sensitivity0.63199850
76MP0003787_abnormal_imprinting0.61388841
77MP0003303_peritoneal_inflammation0.61263791
78MP0001919_abnormal_reproductive_system0.61072805
79MP0004130_abnormal_muscle_cell0.60558415
80MP0000015_abnormal_ear_pigmentation0.60355159
81MP0004883_abnormal_blood_vessel0.60149004
82MP0001502_abnormal_circadian_rhythm0.59516228
83MP0005360_urolithiasis0.58590796
84MP0003172_abnormal_lysosome_physiology0.58301921
85MP0003690_abnormal_glial_cell0.58092420
86MP0005645_abnormal_hypothalamus_physiol0.55399199
87MP0002138_abnormal_hepatobiliary_system0.54537385
88MP0004036_abnormal_muscle_relaxation0.53806944
89MP0001765_abnormal_ion_homeostasis0.52748670
90MP0005164_abnormal_response_to0.52227260
91MP0004742_abnormal_vestibular_system0.51051006
92MP0005166_decreased_susceptibility_to0.50835025
93MP0002136_abnormal_kidney_physiology0.50267662
94MP0000427_abnormal_hair_cycle0.49148997
95MP0003075_altered_response_to0.48858446
96MP0000609_abnormal_liver_physiology0.48141300
97MP0002095_abnormal_skin_pigmentation0.48003738
98MP0005319_abnormal_enzyme/_coenzyme0.46698483
99MP0003795_abnormal_bone_structure0.45344750
100MP0005584_abnormal_enzyme/coenzyme_acti0.42878686

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.60353272
2Abnormality of T cell number (HP:0011839)8.03296058
3Abnormality of T cells (HP:0002843)5.72885856
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.65422386
5Elevated erythrocyte sedimentation rate (HP:0003565)5.10782454
6Optic neuritis (HP:0100653)4.90437069
7Retrobulbar optic neuritis (HP:0100654)4.90437069
8IgG deficiency (HP:0004315)4.88681201
9Encephalitis (HP:0002383)4.79736310
10Severe combined immunodeficiency (HP:0004430)4.78400072
11Myositis (HP:0100614)4.68309636
12Chronic mucocutaneous candidiasis (HP:0002728)4.68093254
13Recurrent cutaneous fungal infections (HP:0011370)4.68093254
14Orchitis (HP:0100796)4.57147131
15Abnormality of eosinophils (HP:0001879)4.46581494
16Panhypogammaglobulinemia (HP:0003139)4.28682519
17Eczematoid dermatitis (HP:0000976)4.25037025
18Recurrent fungal infections (HP:0002841)4.22805514
19Hypoproteinemia (HP:0003075)4.03355774
20Recurrent viral infections (HP:0004429)3.97571047
21Eosinophilia (HP:0001880)3.92001196
22Increased IgM level (HP:0003496)3.83606430
23Combined immunodeficiency (HP:0005387)3.83362561
24Stomatitis (HP:0010280)3.82865619
25Chronic diarrhea (HP:0002028)3.82520011
26Meningitis (HP:0001287)3.81915724
27Leukocytosis (HP:0001974)3.79916264
28Gastrointestinal infarctions (HP:0005244)3.76201943
29Pustule (HP:0200039)3.68390677
30Autoimmune hemolytic anemia (HP:0001890)3.64746421
31Agammaglobulinemia (HP:0004432)3.62256599
32Granulocytopenia (HP:0001913)3.52117263
33Keratoconjunctivitis sicca (HP:0001097)3.50045624
34Thyroiditis (HP:0100646)3.49874241
35Recurrent bronchitis (HP:0002837)3.46962697
36Abnormality of T cell physiology (HP:0011840)3.45234087
37Vasculitis (HP:0002633)3.38959088
38Pulmonary infiltrates (HP:0002113)3.35737108
39Recurrent skin infections (HP:0001581)3.32218910
40Keratoconjunctivitis (HP:0001096)3.17862243
41Recurrent bacterial skin infections (HP:0005406)3.16691327
42Recurrent abscess formation (HP:0002722)3.13856193
43Hemoptysis (HP:0002105)3.01647909
44Abnormality of macrophages (HP:0004311)3.00760972
45Gangrene (HP:0100758)2.78024616
46Autoimmune thrombocytopenia (HP:0001973)2.74827013
47Hemiplegia (HP:0002301)2.71195739
48Inflammation of the large intestine (HP:0002037)2.63931495
49Hypoplasia of the thymus (HP:0000778)2.63834043
50Colitis (HP:0002583)2.63401106
51Mediastinal lymphadenopathy (HP:0100721)2.57700224
52Anorexia (HP:0002039)2.55919880
53Joint swelling (HP:0001386)2.54801650
54Abnormality of the pleura (HP:0002103)2.48063190
55Pulmonary embolism (HP:0002204)2.46608015
56Chest pain (HP:0100749)2.44346319
57Gastrointestinal inflammation (HP:0004386)2.41656843
58Abnormality of cells of the lymphoid lineage (HP:0012140)2.41100573
59Lymphopenia (HP:0001888)2.40672338
60Arterial thrombosis (HP:0004420)2.40052598
61Bronchitis (HP:0012387)2.32589451
62Congenital stationary night blindness (HP:0007642)2.32400348
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.31787632
64Obstructive lung disease (HP:0006536)2.29392805
65Chronic obstructive pulmonary disease (HP:0006510)2.29392805
66Abnormality of the prostate (HP:0008775)2.28083748
67Keratitis (HP:0000491)2.27288411
68Hypergammaglobulinemia (HP:0010702)2.22232004
69Lymphoma (HP:0002665)2.20651240
70Increased IgE level (HP:0003212)2.14907323
71Abnormality of the pericardium (HP:0001697)2.02794612
72Cutaneous melanoma (HP:0012056)2.01763163
73Glomerulopathy (HP:0100820)2.00205883
74Increased neuronal autofluorescent lipopigment (HP:0002074)1.98656706
75Spontaneous hematomas (HP:0007420)1.91407448
76Aplastic anemia (HP:0001915)1.90968307
77Abnormality of the endocardium (HP:0004306)1.90470884
78Increased CSF protein (HP:0002922)1.88077233
79Abnormality of the renal cortex (HP:0011035)1.86261694
80Metabolic alkalosis (HP:0200114)1.85366853
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84632603
82Acute hepatic failure (HP:0006554)1.82932880
83Skin rash (HP:0000988)1.81893523
84Abnormal rod and cone electroretinograms (HP:0008323)1.81252986
85Gingivitis (HP:0000230)1.81127224
86Dyschromatopsia (HP:0007641)1.79202059
873-Methylglutaconic aciduria (HP:0003535)1.77892101
88Hypoalbuminemia (HP:0003073)1.76707413
89Abnormal albumin level (HP:0012116)1.76707413
90Tetraplegia (HP:0002445)1.76564529
91Alveolar cell carcinoma (HP:0006519)1.74329614
92Hypokalemic alkalosis (HP:0001949)1.73687123
93Increased cerebral lipofuscin (HP:0011813)1.72927310
94Polyneuropathy (HP:0001271)1.71293993
95Renal cortical cysts (HP:0000803)1.68697287
96IgA deficiency (HP:0002720)1.67565664
97Petechiae (HP:0000967)1.67011491
98Acne (HP:0001061)1.66908742
99Abnormal spermatogenesis (HP:0008669)1.65361486
100Neoplasm of the tracheobronchial system (HP:0100552)1.64491101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.76100838
2MAP4K14.30306972
3EPHA33.01942513
4ITK2.77513658
5TAOK32.50998066
6FES2.34806359
7EPHB12.27817709
8CSK2.26077225
9JAK12.06350932
10IRAK42.00926622
11NLK1.90971883
12TNK21.89839234
13TESK21.89284856
14ZAP701.84418575
15FGFR41.77157983
16KDR1.76622776
17JAK31.72383866
18TGFBR21.70706027
19SYK1.70088034
20GRK71.66773630
21TYK21.66076133
22IRAK11.60569960
23BTK1.52223403
24IKBKB1.47096144
25RIPK41.40493689
26PRKCQ1.39865475
27BLK1.39080410
28LCK1.36435232
29MST41.31707815
30TEC1.30258573
31GRK61.26557373
32CSF1R1.25617469
33IKBKE1.21014485
34HCK1.14574722
35MAP3K141.12938252
36LYN1.12606850
37MAP2K31.11971137
38ZAK1.11439133
39PIK3CG1.06174911
40FGFR31.03739170
41CLK11.03228157
42STK101.03194839
43ADRBK20.97532046
44NEK90.91944549
45JAK20.90098326
46MAP3K30.85066542
47PDK10.77416821
48CAMKK20.77295359
49MAP3K100.74748997
50PIK3CA0.74460780
51MARK30.70905911
52NUAK10.68507860
53FYN0.65019024
54MAP3K120.64747763
55TLK10.63584017
56KIT0.61244288
57GRK50.59422476
58MAP3K110.58539218
59FRK0.58402008
60MAP3K130.58293602
61BMPR20.57795142
62TBK10.57608184
63RPS6KA50.56611815
64FER0.54876189
65DAPK20.54479326
66RET0.52336049
67CHUK0.51698797
68HIPK20.51645141
69PIM10.51403249
70MAPK120.50455607
71MAPKAPK20.50120334
72IGF1R0.46492991
73MAP2K60.45618134
74TYRO30.45433352
75DYRK1B0.44067039
76MAP3K10.41299122
77NEK60.40661369
78PTK60.39741053
79MOS0.39037021
80SGK20.37333513
81SGK30.35981327
82CAMKK10.35551428
83MAPK110.34315189
84INSR0.31496724
85PTK2B0.31184162
86TRPM70.30115082
87WNK40.29742042
88PASK0.28751228
89ADRBK10.28567759
90PRKCD0.26820300
91PDGFRB0.25668787
92AKT30.23973008
93FGR0.21881758
94MATK0.20963215
95EIF2AK20.20901630
96DAPK10.20276884
97FGFR10.18267388
98MAP4K20.17998153
99PRKCH0.17025083
100ERN10.16925709

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.09383220
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.34285492
3* Antigen processing and presentation_Homo sapiens_hsa046124.09872184
4Graft-versus-host disease_Homo sapiens_hsa053323.75113550
5T cell receptor signaling pathway_Homo sapiens_hsa046603.24596319
6Allograft rejection_Homo sapiens_hsa053303.18261094
7Autoimmune thyroid disease_Homo sapiens_hsa053203.07107046
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63301003
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50765701
10Type I diabetes mellitus_Homo sapiens_hsa049402.47711285
11Hematopoietic cell lineage_Homo sapiens_hsa046402.47295349
12Measles_Homo sapiens_hsa051622.36921917
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.27055541
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78700831
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77640380
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76255940
17Osteoclast differentiation_Homo sapiens_hsa043801.67802517
18Malaria_Homo sapiens_hsa051441.66879172
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66665943
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.62458925
21Leishmaniasis_Homo sapiens_hsa051401.55112709
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54472102
23Chemokine signaling pathway_Homo sapiens_hsa040621.53642048
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.42143165
25Rheumatoid arthritis_Homo sapiens_hsa053231.35020270
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30919042
27B cell receptor signaling pathway_Homo sapiens_hsa046621.30594801
28Staphylococcus aureus infection_Homo sapiens_hsa051501.23019877
29TNF signaling pathway_Homo sapiens_hsa046681.21033411
30Viral myocarditis_Homo sapiens_hsa054161.16363771
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02315467
32Apoptosis_Homo sapiens_hsa042101.01918359
33Herpes simplex infection_Homo sapiens_hsa051681.01572345
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99311253
35Tuberculosis_Homo sapiens_hsa051520.97869243
36Toxoplasmosis_Homo sapiens_hsa051450.88601747
37Legionellosis_Homo sapiens_hsa051340.84884993
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.84373551
39Nitrogen metabolism_Homo sapiens_hsa009100.84248397
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84201421
41Acute myeloid leukemia_Homo sapiens_hsa052210.82785715
42Platelet activation_Homo sapiens_hsa046110.76007403
43Influenza A_Homo sapiens_hsa051640.74985231
44Proteasome_Homo sapiens_hsa030500.71997593
45Salmonella infection_Homo sapiens_hsa051320.71951460
46African trypanosomiasis_Homo sapiens_hsa051430.70961810
47Asthma_Homo sapiens_hsa053100.65616083
48Caffeine metabolism_Homo sapiens_hsa002320.62245942
49Epstein-Barr virus infection_Homo sapiens_hsa051690.60729101
50Phototransduction_Homo sapiens_hsa047440.60073045
51HTLV-I infection_Homo sapiens_hsa051660.58727427
52Hepatitis B_Homo sapiens_hsa051610.56380883
53Non-small cell lung cancer_Homo sapiens_hsa052230.56036573
54Regulation of autophagy_Homo sapiens_hsa041400.50100980
55Hepatitis C_Homo sapiens_hsa051600.49668466
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48036235
57Pertussis_Homo sapiens_hsa051330.47469351
58Shigellosis_Homo sapiens_hsa051310.47030250
59Viral carcinogenesis_Homo sapiens_hsa052030.44142167
60VEGF signaling pathway_Homo sapiens_hsa043700.43372497
61Linoleic acid metabolism_Homo sapiens_hsa005910.41083067
62Pancreatic cancer_Homo sapiens_hsa052120.40637751
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40523025
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37776730
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35489096
66Olfactory transduction_Homo sapiens_hsa047400.34843594
67Endocytosis_Homo sapiens_hsa041440.34405972
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.33824907
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33746814
70Dorso-ventral axis formation_Homo sapiens_hsa043200.31358180
71ABC transporters_Homo sapiens_hsa020100.30519686
72MAPK signaling pathway_Homo sapiens_hsa040100.29762031
73FoxO signaling pathway_Homo sapiens_hsa040680.28642474
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27109133
75Ras signaling pathway_Homo sapiens_hsa040140.26483229
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26166255
77Phagosome_Homo sapiens_hsa041450.24024239
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23407401
79Circadian rhythm_Homo sapiens_hsa047100.23277160
80Prolactin signaling pathway_Homo sapiens_hsa049170.22843190
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19757066
82Renin secretion_Homo sapiens_hsa049240.19632487
83Insulin resistance_Homo sapiens_hsa049310.19389936
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18047055
85Chronic myeloid leukemia_Homo sapiens_hsa052200.17993195
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17158370
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.17142284
88Inositol phosphate metabolism_Homo sapiens_hsa005620.16998656
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14506729
90Lysosome_Homo sapiens_hsa041420.13374340
91Morphine addiction_Homo sapiens_hsa050320.11890950
92Prion diseases_Homo sapiens_hsa050200.10806912
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08923309
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08637014
95Ether lipid metabolism_Homo sapiens_hsa005650.08116530
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.07961643
97HIF-1 signaling pathway_Homo sapiens_hsa040660.07465207
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07094589
99RNA degradation_Homo sapiens_hsa030180.06664283
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05652472

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