KLRC4-KLRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.80205216
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.80205216
3positive regulation of gamma-delta T cell activation (GO:0046645)6.51917253
4interferon-gamma production (GO:0032609)6.51854245
5cellular response to interleukin-15 (GO:0071350)6.27077495
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.07566169
7regulation of gamma-delta T cell differentiation (GO:0045586)6.04113591
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.02373822
9negative T cell selection (GO:0043383)6.01315584
10positive regulation of natural killer cell mediated immunity (GO:0002717)5.94047671
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.74201605
12regulation of natural killer cell mediated immunity (GO:0002715)5.74201605
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.73598151
14response to interleukin-15 (GO:0070672)5.67250681
15positive regulation of leukocyte mediated cytotoxicity (GO:0001912)5.56972297
16regulation of B cell receptor signaling pathway (GO:0050855)5.52386278
17negative regulation of T cell mediated immunity (GO:0002710)5.44882199
18regulation of leukocyte mediated cytotoxicity (GO:0001910)5.38338307
19positive regulation of alpha-beta T cell proliferation (GO:0046641)5.38276273
20negative thymic T cell selection (GO:0045060)5.38109097
21regulation of gamma-delta T cell activation (GO:0046643)5.36471310
22positive T cell selection (GO:0043368)5.22588852
23positive thymic T cell selection (GO:0045059)5.15577814
24positive regulation of T cell mediated cytotoxicity (GO:0001916)5.10620033
25regulation of alpha-beta T cell proliferation (GO:0046640)5.04267864
26positive regulation of T cell cytokine production (GO:0002726)5.03819999
27regulation of T cell mediated cytotoxicity (GO:0001914)5.00159102
28negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.99560428
29positive regulation of cell killing (GO:0031343)4.95992244
30cytidine deamination (GO:0009972)4.95159846
31cytidine metabolic process (GO:0046087)4.95159846
32cytidine catabolic process (GO:0006216)4.95159846
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92263613
34regulation of T cell chemotaxis (GO:0010819)4.87962846
35positive regulation of T cell chemotaxis (GO:0010820)4.87962846
36T cell migration (GO:0072678)4.85512478
37regulation of cell killing (GO:0031341)4.82590211
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.66036457
39lymphocyte chemotaxis (GO:0048247)4.59766637
40negative regulation of lymphocyte mediated immunity (GO:0002707)4.55027700
41pyrimidine ribonucleoside catabolic process (GO:0046133)4.51375842
42thymic T cell selection (GO:0045061)4.47505901
43antigen processing and presentation of endogenous antigen (GO:0019883)4.46129951
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42327403
45activated T cell proliferation (GO:0050798)4.37039289
46DNA deamination (GO:0045006)4.19811913
47T cell selection (GO:0045058)4.18240007
48regulation of regulatory T cell differentiation (GO:0045589)4.04295405
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.02770296
50negative regulation of T cell apoptotic process (GO:0070233)3.99968451
51negative regulation of leukocyte mediated immunity (GO:0002704)3.99894924
52lymphocyte migration (GO:0072676)3.99575695
53leukocyte aggregation (GO:0070486)3.99033231
54Arp2/3 complex-mediated actin nucleation (GO:0034314)3.94870044
55regulation of lymphocyte chemotaxis (GO:1901623)3.93488035
56T cell receptor signaling pathway (GO:0050852)3.92865967
57mast cell activation (GO:0045576)3.91050222
58regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.89693312
59regulation of B cell differentiation (GO:0045577)3.82437258
60positive regulation of B cell differentiation (GO:0045579)3.81885834
61cellular defense response (GO:0006968)3.78050472
62positive regulation of T cell mediated immunity (GO:0002711)3.77867963
63antigen processing and presentation via MHC class Ib (GO:0002475)3.77718585
64positive regulation of lymphocyte mediated immunity (GO:0002708)3.72259431
65regulation of T cell tolerance induction (GO:0002664)3.71424885
66positive regulation of granulocyte differentiation (GO:0030854)3.70331235
67positive regulation of tolerance induction (GO:0002645)3.69062291
68negative regulation of alpha-beta T cell activation (GO:0046636)3.68730322
69natural killer cell activation (GO:0030101)3.58896639
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.54517650
71negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.53351758
72regulation of T cell receptor signaling pathway (GO:0050856)3.51112135
73antigen receptor-mediated signaling pathway (GO:0050851)3.49708568
74regulation of T cell cytokine production (GO:0002724)3.47786894
75actin nucleation (GO:0045010)3.47075231
76regulation of isotype switching to IgG isotypes (GO:0048302)3.44594276
77T cell costimulation (GO:0031295)3.43647884
78regulation of T cell mediated immunity (GO:0002709)3.42224848
79positive regulation of T-helper 1 type immune response (GO:0002827)3.41298918
80lymphocyte costimulation (GO:0031294)3.39673762
81positive regulation of immunoglobulin mediated immune response (GO:0002891)3.35281770
82positive regulation of B cell mediated immunity (GO:0002714)3.35281770
83negative regulation of adaptive immune response (GO:0002820)3.34898932
84positive regulation of calcium-mediated signaling (GO:0050850)3.33204321
85regulation of lymphocyte mediated immunity (GO:0002706)3.30830860
86positive regulation of leukocyte mediated immunity (GO:0002705)3.30715536
87regulation of activation of Janus kinase activity (GO:0010533)3.28667577
88regulation of tolerance induction (GO:0002643)3.26859404
89mast cell activation involved in immune response (GO:0002279)3.26074325
90mast cell degranulation (GO:0043303)3.26074325
91regulation of T-helper 1 type immune response (GO:0002825)3.21659144
92positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.21156061
93regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.09778817
94mucosal-associated lymphoid tissue development (GO:0048537)3.08916337
95Peyers patch development (GO:0048541)3.08916337
96regulation of alpha-beta T cell activation (GO:0046634)3.08906880
97positive regulation of interleukin-4 production (GO:0032753)3.06502902
98regulation of interleukin-2 biosynthetic process (GO:0045076)3.05811911
99positive regulation of alpha-beta T cell activation (GO:0046635)3.03002871
100positive regulation of lymphocyte migration (GO:2000403)3.02737363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.59567108
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.58096374
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.35653375
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.82523026
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.37280103
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.02577648
7RUNX_20019798_ChIP-Seq_JUKART_Human3.73428409
8MYB_26560356_Chip-Seq_TH2_Human3.51933734
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50638627
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.32211486
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87354312
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.62213429
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61907369
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49267420
15GATA3_27048872_Chip-Seq_THYMUS_Human2.46168995
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45718288
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43371710
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38945445
19MYB_26560356_Chip-Seq_TH1_Human2.38001407
20UTX_26944678_Chip-Seq_JUKART_Human2.17972150
21GATA3_26560356_Chip-Seq_TH2_Human2.17219541
22MAF_26560356_Chip-Seq_TH1_Human2.11647224
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07103773
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.05148114
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93374489
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.92932306
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.85989941
28SPI1_23547873_ChIP-Seq_NB4_Human1.81687698
29MAF_26560356_Chip-Seq_TH2_Human1.79366373
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69632470
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68169068
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.67220424
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48146007
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43092723
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42463249
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40590945
37SCL_19346495_ChIP-Seq_HPC-7_Human1.38903665
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38565117
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36180374
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36079966
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34791169
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.33915933
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28022855
44GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27571590
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22784752
46VDR_23849224_ChIP-Seq_CD4+_Human1.20822705
47TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18837366
48VDR_22108803_ChIP-Seq_LS180_Human1.18751818
49SPI1_23127762_ChIP-Seq_K562_Human1.18448701
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17754181
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06524718
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05492862
53VDR_24787735_ChIP-Seq_THP-1_Human1.05013852
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03839429
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.03359328
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01900138
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00903537
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00609285
59GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96959983
60EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95458547
61GATA3_26560356_Chip-Seq_TH1_Human0.94464671
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92590745
63BCL6_27268052_Chip-Seq_Bcells_Human0.92025132
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90086704
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89706908
66FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88028789
67EZH2_27294783_Chip-Seq_NPCs_Mouse0.86636199
68GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86602742
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86238409
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85780841
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85519377
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.84958705
73SMRT_27268052_Chip-Seq_Bcells_Human0.84595693
74P300_27268052_Chip-Seq_Bcells_Human0.84232414
75FOXP3_21729870_ChIP-Seq_TREG_Human0.84230345
76SPI1_20517297_ChIP-Seq_HL60_Human0.83807583
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83024877
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82816724
79HTT_18923047_ChIP-ChIP_STHdh_Human0.82752671
80TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81673944
81PU_27001747_Chip-Seq_BMDM_Mouse0.81619963
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81377963
83VDR_24763502_ChIP-Seq_THP-1_Human0.80274425
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80004152
85NANOG_20526341_ChIP-Seq_ESCs_Human0.79907635
86BCOR_27268052_Chip-Seq_Bcells_Human0.79813744
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77638190
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.77528274
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75977290
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75837752
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75779079
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75562139
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.72687924
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71364708
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.71056699
96CIITA_25753668_ChIP-Seq_RAJI_Human0.70534100
97AR_20517297_ChIP-Seq_VCAP_Human0.70389075
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70346765
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70058943
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69308463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.00693447
2MP0003763_abnormal_thymus_physiology4.40066983
3MP0001835_abnormal_antigen_presentation3.84446811
4MP0009785_altered_susceptibility_to3.65683901
5MP0005000_abnormal_immune_tolerance3.34027971
6MP0001800_abnormal_humoral_immune3.20741908
7MP0003436_decreased_susceptibility_to3.02258715
8MP0005025_abnormal_response_to2.92524474
9MP0002723_abnormal_immune_serum2.92072275
10MP0000685_abnormal_immune_system2.91321582
11MP0009333_abnormal_splenocyte_physiolog2.91181858
12MP0003724_increased_susceptibility_to2.89734589
13MP0002420_abnormal_adaptive_immunity2.89622280
14MP0001819_abnormal_immune_cell2.84189341
15MP0005387_immune_system_phenotype2.79026631
16MP0001790_abnormal_immune_system2.79026631
17MP0002452_abnormal_antigen_presenting2.55836688
18MP0002006_tumorigenesis2.50601151
19MP0002166_altered_tumor_susceptibility2.43267344
20MP0002419_abnormal_innate_immunity2.35785941
21MP0006082_CNS_inflammation2.32821141
22MP0002398_abnormal_bone_marrow2.28411276
23MP0000716_abnormal_immune_system2.22777482
24MP0002148_abnormal_hypersensitivity_rea2.21353878
25MP0000703_abnormal_thymus_morphology2.19372645
26MP0004381_abnormal_hair_follicle2.17987990
27MP0003866_abnormal_defecation2.15375697
28MP0002405_respiratory_system_inflammati2.04707209
29MP0002722_abnormal_immune_system1.94679438
30MP0000689_abnormal_spleen_morphology1.94147485
31MP0010155_abnormal_intestine_physiology1.88042255
32MP0004947_skin_inflammation1.86424200
33MP0005075_abnormal_melanosome_morpholog1.82681273
34MP0001845_abnormal_inflammatory_respons1.78318375
35MP0003646_muscle_fatigue1.75793829
36MP0002429_abnormal_blood_cell1.70701531
37MP0003448_altered_tumor_morphology1.67194250
38MP0005310_abnormal_salivary_gland1.63725474
39MP0001533_abnormal_skeleton_physiology1.48050686
40MP0001986_abnormal_taste_sensitivity1.48011245
41MP0003878_abnormal_ear_physiology1.47276366
42MP0005377_hearing/vestibular/ear_phenot1.47276366
43MP0005464_abnormal_platelet_physiology1.45100857
44MP0003045_fibrosis1.41208946
45MP0008469_abnormal_protein_level1.38143629
46MP0001873_stomach_inflammation1.33295192
47MP0001853_heart_inflammation1.32278079
48MP0002933_joint_inflammation1.31685415
49MP0000858_altered_metastatic_potential1.17893441
50MP0005645_abnormal_hypothalamus_physiol1.13034358
51MP0009764_decreased_sensitivity_to1.08770415
52MP0000569_abnormal_digit_pigmentation1.06171231
53MP0009763_increased_sensitivity_to1.03380971
54MP0005166_decreased_susceptibility_to0.87784028
55MP0002019_abnormal_tumor_incidence0.86823823
56MP0003300_gastrointestinal_ulcer0.85907302
57MP0000015_abnormal_ear_pigmentation0.82389838
58MP0004130_abnormal_muscle_cell0.81753780
59MP0000465_gastrointestinal_hemorrhage0.81739771
60MP0002998_abnormal_bone_remodeling0.80315973
61MP0002693_abnormal_pancreas_physiology0.77129978
62MP0002009_preneoplasia0.75642845
63MP0003303_peritoneal_inflammation0.73020774
64MP0001501_abnormal_sleep_pattern0.71803179
65MP0002138_abnormal_hepatobiliary_system0.71231910
66MP0002277_abnormal_respiratory_mucosa0.70870037
67MP0008872_abnormal_physiological_respon0.67812850
68MP0001765_abnormal_ion_homeostasis0.64185510
69MP0003786_premature_aging0.63332034
70MP0002136_abnormal_kidney_physiology0.62920102
71MP0004142_abnormal_muscle_tone0.60838344
72MP0002396_abnormal_hematopoietic_system0.59660263
73MP0001919_abnormal_reproductive_system0.59651009
74MP0003075_altered_response_to0.58190927
75MP0005174_abnormal_tail_pigmentation0.56497710
76MP0003183_abnormal_peptide_metabolism0.56240571
77MP0008877_abnormal_DNA_methylation0.55752602
78MP0003690_abnormal_glial_cell0.54642270
79MP0005451_abnormal_body_composition0.54291538
80MP0005410_abnormal_fertilization0.52642957
81MP0003252_abnormal_bile_duct0.51961640
82MP0005085_abnormal_gallbladder_physiolo0.51368774
83MP0005390_skeleton_phenotype0.51367008
84MP0008873_increased_physiological_sensi0.51150032
85MP0002132_abnormal_respiratory_system0.50577444
86MP0004883_abnormal_blood_vessel0.50400214
87MP0003195_calcinosis0.49760820
88MP0009765_abnormal_xenobiotic_induced0.49708242
89MP0002095_abnormal_skin_pigmentation0.48296697
90MP0009643_abnormal_urine_homeostasis0.46175577
91MP0003795_abnormal_bone_structure0.45854225
92MP0000604_amyloidosis0.45835838
93MP0002102_abnormal_ear_morphology0.45357461
94MP0001851_eye_inflammation0.45275006
95MP0000609_abnormal_liver_physiology0.42841018
96MP0000920_abnormal_myelination0.42620101
97MP0009642_abnormal_blood_homeostasis0.41550605
98MP0001905_abnormal_dopamine_level0.40648463
99MP0005584_abnormal_enzyme/coenzyme_acti0.39868447
100MP0003638_abnormal_response/metabolism_0.39523986

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.47349207
2Abnormality of T cell number (HP:0011839)6.88030674
3Optic neuritis (HP:0100653)5.85222683
4Retrobulbar optic neuritis (HP:0100654)5.85222683
5Myositis (HP:0100614)5.46172852
6Orchitis (HP:0100796)5.25769120
7IgG deficiency (HP:0004315)5.10461369
8Abnormality of T cells (HP:0002843)5.05351903
9Severe combined immunodeficiency (HP:0004430)4.97886646
10Encephalitis (HP:0002383)4.96079810
11Elevated erythrocyte sedimentation rate (HP:0003565)4.85542434
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.37782680
13Keratoconjunctivitis sicca (HP:0001097)4.36620147
14Hypoproteinemia (HP:0003075)4.17143044
15Keratoconjunctivitis (HP:0001096)4.14622211
16Recurrent cutaneous fungal infections (HP:0011370)4.14437756
17Chronic mucocutaneous candidiasis (HP:0002728)4.14437756
18Combined immunodeficiency (HP:0005387)3.91773110
19Autoimmune hemolytic anemia (HP:0001890)3.89771623
20Recurrent fungal infections (HP:0002841)3.83616493
21Abnormality of eosinophils (HP:0001879)3.81342591
22Panhypogammaglobulinemia (HP:0003139)3.80793854
23Meningitis (HP:0001287)3.75294945
24Stomatitis (HP:0010280)3.70177597
25Aplastic anemia (HP:0001915)3.65810268
26Thyroiditis (HP:0100646)3.61353808
27Increased IgM level (HP:0003496)3.57310850
28Eczematoid dermatitis (HP:0000976)3.55210879
29Recurrent bronchitis (HP:0002837)3.55062260
30Chronic diarrhea (HP:0002028)3.42014886
31Abnormality of macrophages (HP:0004311)3.40705548
32Vasculitis (HP:0002633)3.36029558
33Pulmonary infiltrates (HP:0002113)3.33526276
34Gastrointestinal infarctions (HP:0005244)3.28009932
35Recurrent bacterial skin infections (HP:0005406)3.24364175
36Hemoptysis (HP:0002105)3.22054829
37Leukocytosis (HP:0001974)3.20518928
38Recurrent viral infections (HP:0004429)3.18891039
39Abnormality of T cell physiology (HP:0011840)3.13045997
40Recurrent abscess formation (HP:0002722)3.05575877
41Eosinophilia (HP:0001880)3.05358901
42Recurrent skin infections (HP:0001581)3.02777766
43Gangrene (HP:0100758)3.02126734
44Pustule (HP:0200039)2.90887041
45Lymphopenia (HP:0001888)2.86710370
46Agammaglobulinemia (HP:0004432)2.85164920
47Arterial thrombosis (HP:0004420)2.83649027
48Pulmonary embolism (HP:0002204)2.82532224
49Inflammation of the large intestine (HP:0002037)2.80248391
50Anorexia (HP:0002039)2.80164187
51Joint swelling (HP:0001386)2.75103656
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.69950188
53Granulocytopenia (HP:0001913)2.67304819
54Keratitis (HP:0000491)2.65283515
55Autoimmune thrombocytopenia (HP:0001973)2.59594793
56Mediastinal lymphadenopathy (HP:0100721)2.59232182
57Hypoplasia of the thymus (HP:0000778)2.57514495
58Congenital stationary night blindness (HP:0007642)2.57323954
59Gastrointestinal inflammation (HP:0004386)2.52435979
60Chronic obstructive pulmonary disease (HP:0006510)2.48072405
61Obstructive lung disease (HP:0006536)2.48072405
62Spontaneous hematomas (HP:0007420)2.47055243
63IgM deficiency (HP:0002850)2.46384084
64Abnormality of the pleura (HP:0002103)2.42675874
65Hemiplegia (HP:0002301)2.41259345
66Chest pain (HP:0100749)2.35994296
67Bronchitis (HP:0012387)2.33850561
683-Methylglutaconic aciduria (HP:0003535)2.33224455
69Lymphoma (HP:0002665)2.30819627
70Abnormality of B cell number (HP:0010975)2.28011963
71Acute hepatic failure (HP:0006554)2.23598640
72Glomerulopathy (HP:0100820)2.17773794
73Hypergammaglobulinemia (HP:0010702)2.17773310
74Slow saccadic eye movements (HP:0000514)2.16152217
75Abnormality of the prostate (HP:0008775)2.15427525
76Stomach cancer (HP:0012126)2.15287404
77Pigmentary retinal degeneration (HP:0001146)2.10129564
78Polyneuropathy (HP:0001271)2.06521415
79Gingival bleeding (HP:0000225)2.05648829
80Colitis (HP:0002583)2.05533164
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92320463
82Recurrent gram-negative bacterial infections (HP:0005420)1.91333730
83Acne (HP:0001061)1.90410550
84Abnormality of the pericardium (HP:0001697)1.88204587
85Increased IgE level (HP:0003212)1.87259767
86B lymphocytopenia (HP:0010976)1.85790085
87Abnormality of the endocardium (HP:0004306)1.85162145
88Vertigo (HP:0002321)1.84922080
89Renal cortical cysts (HP:0000803)1.84194058
90Epistaxis (HP:0000421)1.81911374
91Pancytopenia (HP:0001876)1.75897441
92Urticaria (HP:0001025)1.73177955
93Abnormal rod and cone electroretinograms (HP:0008323)1.70676569
94Chronic otitis media (HP:0000389)1.69571719
95Thrombophlebitis (HP:0004418)1.68830783
96Arthralgia (HP:0002829)1.67277020
97Microcytic anemia (HP:0001935)1.66583775
98Hyperlipoproteinemia (HP:0010980)1.66299839
99Pancreatitis (HP:0001733)1.63217338
100Petechiae (HP:0000967)1.59231660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.39203883
2TESK23.64448843
3MAP4K13.62421021
4TAOK33.14894871
5KDR3.14277900
6FES2.55425901
7MAP4K22.28905793
8CSK2.28337158
9ITK2.27865178
10GRK62.27327701
11IKBKE2.10403994
12JAK31.98481451
13ZAP701.82571744
14SYK1.79520018
15RIPK41.73305655
16JAK11.70695747
17BTK1.70380584
18NEK91.69243038
19MAP3K111.62702889
20LCK1.59934024
21MAP3K141.49615984
22TESK11.48062635
23TYK21.46192758
24MAP3K121.42659823
25PASK1.39635303
26GRK71.37840559
27NLK1.31383938
28CAMKK21.31120739
29TEC1.29844676
30TLK11.29797216
31LYN1.24533451
32MUSK1.24044989
33PRKCQ1.21508856
34IKBKB1.21350302
35BLK1.19523252
36IRAK41.19086149
37TBK11.19051776
38CSF1R1.04385603
39TNK21.02308768
40ADRBK21.00616562
41CAMKK11.00252186
42HCK0.96986630
43ZAK0.96951417
44SCYL20.94344564
45STK100.93647784
46KIT0.84590306
47MAP2K30.80790080
48PIK3CG0.80537762
49CLK10.75169889
50MAP3K30.73357597
51MARK30.72195896
52JAK20.72034657
53BMPR20.70901686
54FYN0.70071685
55MST40.69602501
56PIM10.69152153
57CDK190.65462611
58FGR0.61410215
59TGFBR20.61270061
60MAP2K60.60636794
61MATK0.60064911
62MAPKAPK30.57560214
63IGF1R0.56687179
64MAPK110.56285398
65PDK10.54921040
66NUAK10.54291794
67MAP3K100.51347604
68WNK40.49620981
69FRK0.48056254
70NEK60.43219657
71MAP3K50.42934492
72OXSR10.41683099
73EPHA30.41086330
74GRK10.40607056
75SIK20.40402411
76INSR0.39542453
77MAP2K20.38314104
78MAPKAPK20.37153361
79EPHB10.36525184
80LIMK10.36002075
81FGFR40.34641686
82GRK50.34051870
83TAOK20.33529143
84TAOK10.31602448
85CDK40.30014358
86PRKCH0.27624171
87LRRK20.26756184
88EGFR0.24837566
89DAPK10.24557736
90MAPK70.24208897
91TRPM70.23770989
92ADRBK10.23528624
93PIK3CA0.22735016
94TYRO30.22689792
95FGFR30.22552355
96ERBB20.22441867
97RPS6KA50.20857417
98HIPK20.20688979
99MAP3K10.20159226
100SIK30.20095849

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.29476742
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.11273566
3Antigen processing and presentation_Homo sapiens_hsa046123.99668027
4Graft-versus-host disease_Homo sapiens_hsa053323.95497967
5T cell receptor signaling pathway_Homo sapiens_hsa046603.48096332
6Allograft rejection_Homo sapiens_hsa053302.94941005
7Autoimmune thyroid disease_Homo sapiens_hsa053202.94923108
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61189819
9Hematopoietic cell lineage_Homo sapiens_hsa046402.56515721
10Measles_Homo sapiens_hsa051622.40320377
11Type I diabetes mellitus_Homo sapiens_hsa049402.35552990
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31481386
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.24532761
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.79243990
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.77937843
16Osteoclast differentiation_Homo sapiens_hsa043801.62242901
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.59505315
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57273752
19Proteasome_Homo sapiens_hsa030501.55915348
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.54194114
21Chemokine signaling pathway_Homo sapiens_hsa040621.53923682
22* Malaria_Homo sapiens_hsa051441.48226005
23Leishmaniasis_Homo sapiens_hsa051401.43076784
24B cell receptor signaling pathway_Homo sapiens_hsa046621.40375516
25Viral myocarditis_Homo sapiens_hsa054161.36851685
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36502449
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33213798
28Staphylococcus aureus infection_Homo sapiens_hsa051501.21376498
29Herpes simplex infection_Homo sapiens_hsa051681.20714026
30Rheumatoid arthritis_Homo sapiens_hsa053231.13914222
31TNF signaling pathway_Homo sapiens_hsa046681.12959026
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12690550
33Nitrogen metabolism_Homo sapiens_hsa009101.09326075
34Shigellosis_Homo sapiens_hsa051311.09152832
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06873452
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00900276
37Legionellosis_Homo sapiens_hsa051340.95587064
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92505270
39Asthma_Homo sapiens_hsa053100.88395294
40Tuberculosis_Homo sapiens_hsa051520.87388791
41Apoptosis_Homo sapiens_hsa042100.86434077
42Phototransduction_Homo sapiens_hsa047440.84184396
43Platelet activation_Homo sapiens_hsa046110.74020300
44Salmonella infection_Homo sapiens_hsa051320.73456470
45Influenza A_Homo sapiens_hsa051640.72428988
46Epstein-Barr virus infection_Homo sapiens_hsa051690.71731523
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.71611781
48ABC transporters_Homo sapiens_hsa020100.69366594
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65209727
50Toxoplasmosis_Homo sapiens_hsa051450.63537965
51Pertussis_Homo sapiens_hsa051330.63183324
52HTLV-I infection_Homo sapiens_hsa051660.62934312
53RNA polymerase_Homo sapiens_hsa030200.62441165
54Olfactory transduction_Homo sapiens_hsa047400.56639612
55Caffeine metabolism_Homo sapiens_hsa002320.56320187
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56050975
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53505878
58Linoleic acid metabolism_Homo sapiens_hsa005910.53304011
59Viral carcinogenesis_Homo sapiens_hsa052030.52849018
60Acute myeloid leukemia_Homo sapiens_hsa052210.48826173
61Hepatitis B_Homo sapiens_hsa051610.46427972
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44704756
63Endocytosis_Homo sapiens_hsa041440.42272277
64African trypanosomiasis_Homo sapiens_hsa051430.41600347
65Oxidative phosphorylation_Homo sapiens_hsa001900.40943030
66Regulation of autophagy_Homo sapiens_hsa041400.39776147
67MAPK signaling pathway_Homo sapiens_hsa040100.38656063
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38335655
69Morphine addiction_Homo sapiens_hsa050320.35494996
70Phagosome_Homo sapiens_hsa041450.34197773
71One carbon pool by folate_Homo sapiens_hsa006700.31891196
72Ras signaling pathway_Homo sapiens_hsa040140.31608694
73Parkinsons disease_Homo sapiens_hsa050120.30109073
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29706080
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28817529
76Hepatitis C_Homo sapiens_hsa051600.28670935
77Basal transcription factors_Homo sapiens_hsa030220.27079090
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26774997
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25156988
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.23483050
81Prolactin signaling pathway_Homo sapiens_hsa049170.23064881
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20448719
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19874908
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.19739304
85Taste transduction_Homo sapiens_hsa047420.19522588
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19365564
87VEGF signaling pathway_Homo sapiens_hsa043700.17009897
88Systemic lupus erythematosus_Homo sapiens_hsa053220.15700227
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14989983
90Non-small cell lung cancer_Homo sapiens_hsa052230.14319500
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.14162454
92Renin secretion_Homo sapiens_hsa049240.14141388
93Alzheimers disease_Homo sapiens_hsa050100.13851622
94Peroxisome_Homo sapiens_hsa041460.13720576
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13639990
96Glycerolipid metabolism_Homo sapiens_hsa005610.11322315
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10859181
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09453571
99Salivary secretion_Homo sapiens_hsa049700.08557107
100Arachidonic acid metabolism_Homo sapiens_hsa005900.08541028

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