KLRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)8.35118363
2negative T cell selection (GO:0043383)7.76935432
3negative thymic T cell selection (GO:0045060)7.46388899
4positive thymic T cell selection (GO:0045059)7.21133719
5T cell migration (GO:0072678)7.15790083
6positive regulation of gamma-delta T cell activation (GO:0046645)6.76811691
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.72654010
8negative regulation of cell killing (GO:0031342)6.72654010
9regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.52402782
10regulation of natural killer cell mediated immunity (GO:0002715)6.52402782
11positive T cell selection (GO:0043368)6.42373828
12thymic T cell selection (GO:0045061)6.31900426
13regulation of isotype switching to IgG isotypes (GO:0048302)6.28517198
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.27858117
15cellular response to interleukin-15 (GO:0071350)6.13494553
16positive regulation of natural killer cell mediated immunity (GO:0002717)6.01595607
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.01595607
18leukocyte aggregation (GO:0070486)5.79339001
19response to interleukin-15 (GO:0070672)5.71912939
20regulation of B cell receptor signaling pathway (GO:0050855)5.63055369
21activated T cell proliferation (GO:0050798)5.58036004
22T cell selection (GO:0045058)5.32582336
23regulation of gamma-delta T cell differentiation (GO:0045586)5.32379858
24positive regulation of alpha-beta T cell proliferation (GO:0046641)5.26661066
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.22129591
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.22129591
27DNA deamination (GO:0045006)5.15198086
28regulation of T cell tolerance induction (GO:0002664)5.03536382
29T cell receptor signaling pathway (GO:0050852)5.01939911
30regulation of alpha-beta T cell proliferation (GO:0046640)4.94688714
31regulation of leukocyte mediated cytotoxicity (GO:0001910)4.93590764
32cellular defense response (GO:0006968)4.91810700
33sequestering of actin monomers (GO:0042989)4.89664838
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.85914429
35T cell costimulation (GO:0031295)4.85118216
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83473108
37regulation of gamma-delta T cell activation (GO:0046643)4.81313556
38lymphocyte costimulation (GO:0031294)4.75767941
39cytidine metabolic process (GO:0046087)4.75416544
40cytidine catabolic process (GO:0006216)4.75416544
41cytidine deamination (GO:0009972)4.75416544
42antigen processing and presentation of endogenous antigen (GO:0019883)4.75059752
43lymphocyte migration (GO:0072676)4.68038729
44positive regulation of B cell mediated immunity (GO:0002714)4.56586448
45positive regulation of immunoglobulin mediated immune response (GO:0002891)4.56586448
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.53074182
47negative regulation of T cell mediated immunity (GO:0002710)4.52827371
48regulation of response to tumor cell (GO:0002834)4.50185491
49positive regulation of response to tumor cell (GO:0002836)4.50185491
50positive regulation of immune response to tumor cell (GO:0002839)4.50185491
51regulation of immune response to tumor cell (GO:0002837)4.50185491
52positive regulation of cell killing (GO:0031343)4.50021105
53regulation of cell killing (GO:0031341)4.49818610
54antigen receptor-mediated signaling pathway (GO:0050851)4.45784271
55positive regulation of isotype switching (GO:0045830)4.43066528
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.35352859
57pyrimidine ribonucleoside catabolic process (GO:0046133)4.28845211
58natural killer cell activation (GO:0030101)4.20283925
59positive regulation of T cell chemotaxis (GO:0010820)4.19910881
60regulation of T cell chemotaxis (GO:0010819)4.19910881
61regulation of T cell receptor signaling pathway (GO:0050856)4.19070340
62regulation of immunoglobulin mediated immune response (GO:0002889)4.07419185
63regulation of B cell mediated immunity (GO:0002712)4.02784909
64mast cell activation (GO:0045576)4.00362634
65positive regulation of DNA recombination (GO:0045911)3.95060794
66positive regulation of tolerance induction (GO:0002645)3.91860931
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.90212733
68leukocyte cell-cell adhesion (GO:0007159)3.89734464
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72030648
70regulation of isotype switching (GO:0045191)3.71735869
71heterotypic cell-cell adhesion (GO:0034113)3.70844923
72regulation of B cell differentiation (GO:0045577)3.70384658
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64259599
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57987306
75regulation of regulatory T cell differentiation (GO:0045589)3.56474957
76regulation of lymphocyte mediated immunity (GO:0002706)3.54886929
77positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.53388222
78regulation of response to interferon-gamma (GO:0060330)3.52799983
79regulation of tolerance induction (GO:0002643)3.52550575
80negative regulation of type 2 immune response (GO:0002829)3.48119203
81regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.47940483
82positive regulation of lymphocyte mediated immunity (GO:0002708)3.46696016
83positive regulation of lamellipodium assembly (GO:0010592)3.46415445
84B cell receptor signaling pathway (GO:0050853)3.46058596
85positive regulation of defense response to virus by host (GO:0002230)3.45269076
86tryptophan catabolic process (GO:0006569)3.43985952
87indole-containing compound catabolic process (GO:0042436)3.43985952
88indolalkylamine catabolic process (GO:0046218)3.43985952
89negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.43985328
90regulation of lymphocyte chemotaxis (GO:1901623)3.43692101
91negative regulation of leukocyte mediated immunity (GO:0002704)3.41872142
92T cell differentiation (GO:0030217)3.39968399
93positive regulation of immunoglobulin production (GO:0002639)3.36427885
94T cell activation (GO:0042110)3.36275984
95indolalkylamine metabolic process (GO:0006586)3.36086782
96positive regulation of humoral immune response (GO:0002922)3.33465391
97positive regulation of T-helper 1 type immune response (GO:0002827)3.33006004
98regulation of interleukin-12 biosynthetic process (GO:0045075)3.32305473
99negative regulation of T cell receptor signaling pathway (GO:0050860)3.32122085
100cellular extravasation (GO:0045123)3.27697147
101regulation of hypersensitivity (GO:0002883)3.24133876
102adaptation of signaling pathway (GO:0023058)3.21048947
103regulation of T cell mediated cytotoxicity (GO:0001914)3.19974036
104immune response-activating cell surface receptor signaling pathway (GO:0002429)3.19074451
105positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18330015
106lymphocyte chemotaxis (GO:0048247)3.17687598
107regulation of type I interferon-mediated signaling pathway (GO:0060338)3.14876878
108cytolysis (GO:0019835)3.12775570
109positive regulation of interferon-gamma production (GO:0032729)3.11873839
110positive regulation of interleukin-2 production (GO:0032743)3.10248012
111T cell homeostasis (GO:0043029)3.09363443
112kynurenine metabolic process (GO:0070189)3.08170248
113sulfation (GO:0051923)3.07658626
114regulation of immunoglobulin production (GO:0002637)3.06306182
115response to type I interferon (GO:0034340)3.05330045
116tryptophan metabolic process (GO:0006568)3.00787582
117positive regulation of calcium-mediated signaling (GO:0050850)2.97919826
118neural tube formation (GO:0001841)2.96371833
119negative regulation of mast cell activation (GO:0033004)2.94673532
120signal peptide processing (GO:0006465)2.91118924
121behavioral response to nicotine (GO:0035095)2.83874642
122regulation of activation of Janus kinase activity (GO:0010533)2.83378430
123fucose catabolic process (GO:0019317)2.82978874
124L-fucose metabolic process (GO:0042354)2.82978874
125L-fucose catabolic process (GO:0042355)2.82978874
126negative regulation of B cell proliferation (GO:0030889)2.82396153
127regulation of memory T cell differentiation (GO:0043380)2.79400970
128establishment of protein localization to Golgi (GO:0072600)2.78603809
129positive regulation of granulocyte differentiation (GO:0030854)2.77712335
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77003028
131microglial cell activation (GO:0001774)2.63386651
132negative regulation by host of viral transcription (GO:0043922)2.63289242
133cilium or flagellum-dependent cell motility (GO:0001539)2.63024605
134negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.59989024
135negative regulation of calcium ion transport into cytosol (GO:0010523)2.59311720
136protein K48-linked deubiquitination (GO:0071108)2.58769015
137cellular response to ethanol (GO:0071361)2.56611602
138detection of light stimulus involved in sensory perception (GO:0050962)2.56158202
139detection of light stimulus involved in visual perception (GO:0050908)2.56158202
140regulation of posttranscriptional gene silencing (GO:0060147)2.53070220
141regulation of gene silencing by miRNA (GO:0060964)2.53070220
142regulation of gene silencing by RNA (GO:0060966)2.53070220
143positive regulation of B cell differentiation (GO:0045579)2.50743186

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.23317569
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.44602507
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.92400519
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.30035358
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.15343548
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.95957923
7RUNX_20019798_ChIP-Seq_JUKART_Human3.92192517
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.72208445
9MYB_26560356_Chip-Seq_TH2_Human3.35756528
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.31906191
11MAF_26560356_Chip-Seq_TH1_Human3.10399793
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.09883765
13* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05907568
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00800538
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.92930268
16MYB_26560356_Chip-Seq_TH1_Human2.89910132
17MYC_22102868_ChIP-Seq_BL_Human2.81171029
18UTX_26944678_Chip-Seq_JUKART_Human2.73503230
19GBX2_23144817_ChIP-Seq_PC3_Human2.51038156
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48384853
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43390310
22VDR_22108803_ChIP-Seq_LS180_Human2.38691367
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.33832676
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29427908
25ZNF274_21170338_ChIP-Seq_K562_Hela2.24876572
26SPI1_23547873_ChIP-Seq_NB4_Human2.21668464
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18715936
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.18025521
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.13564854
30* GATA3_27048872_Chip-Seq_THYMUS_Human2.12210352
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12063848
32SCL_19346495_ChIP-Seq_HPC-7_Human2.10331594
33VDR_21846776_ChIP-Seq_THP-1_Human2.06549700
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01999125
35E2F7_22180533_ChIP-Seq_HELA_Human1.98793581
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97804271
37MAF_26560356_Chip-Seq_TH2_Human1.92859322
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.91848726
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.87151955
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86374789
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85906422
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85133576
43EZH2_22144423_ChIP-Seq_EOC_Human1.81445665
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79818618
45ER_23166858_ChIP-Seq_MCF-7_Human1.78341078
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77283825
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74848345
48IGF1R_20145208_ChIP-Seq_DFB_Human1.70284772
49TCF7_22412390_ChIP-Seq_EML_Mouse1.67564900
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66734738
51VDR_24763502_ChIP-Seq_THP-1_Human1.66212005
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65942933
53TAF15_26573619_Chip-Seq_HEK293_Human1.64148975
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62783503
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62665694
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60402791
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52880785
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52293232
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48884422
60STAT3_23295773_ChIP-Seq_U87_Human1.47615125
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46968474
62SPI1_23127762_ChIP-Seq_K562_Human1.45126401
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45056291
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44959146
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44613270
66BCAT_22108803_ChIP-Seq_LS180_Human1.44464844
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44243766
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43257257
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43129722
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42265519
71P300_19829295_ChIP-Seq_ESCs_Human1.41962919
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41136868
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40311439
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.39732466
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38225076
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37848057
77KDM2B_26808549_Chip-Seq_DND41_Human1.37372702
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.37032704
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35271104
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.34407193
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33349168
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32454335
83PU_27001747_Chip-Seq_BMDM_Mouse1.32452861
84TCF4_23295773_ChIP-Seq_U87_Human1.31733735
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31005735
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.30683553
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30519295
88* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30000294
89DROSHA_22980978_ChIP-Seq_HELA_Human1.29287804
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28834204
91AR_21572438_ChIP-Seq_LNCaP_Human1.26325199
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26264027
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25061691
94CBP_20019798_ChIP-Seq_JUKART_Human1.24175774
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24175774
96* GATA3_26560356_Chip-Seq_TH2_Human1.23836653
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23733086
98GATA1_22025678_ChIP-Seq_K562_Human1.23655663
99SMAD4_21799915_ChIP-Seq_A2780_Human1.21846310
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19626147
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19626147
102TP53_16413492_ChIP-PET_HCT116_Human1.19011143
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17532879
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16855098
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.15279850
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14850069
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13450889
108IRF1_19129219_ChIP-ChIP_H3396_Human1.13399033
109EWS_26573619_Chip-Seq_HEK293_Human1.13193698
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12877328
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10490242
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09874826
113SOX2_19829295_ChIP-Seq_ESCs_Human1.09403200
114NANOG_19829295_ChIP-Seq_ESCs_Human1.09403200
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.08457334
116VDR_23849224_ChIP-Seq_CD4+_Human1.07904331
117TP53_22573176_ChIP-Seq_HFKS_Human1.07718534
118* SMRT_27268052_Chip-Seq_Bcells_Human1.07260979
119* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07214926
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06919869
121* FOXA1_25329375_ChIP-Seq_VCAP_Human1.06349799
122* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06349799
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06168143
124* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06033367
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06003685
126FUS_26573619_Chip-Seq_HEK293_Human1.05985696
127EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05628189
128AR_25329375_ChIP-Seq_VCAP_Human1.05538859
129GATA3_21878914_ChIP-Seq_MCF-7_Human1.04805464
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04110791
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04045218
132ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04021431
133KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03942151
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.03354513
135VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02705694
136TCF4_22108803_ChIP-Seq_LS180_Human1.02675052
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01563513
138RXR_22108803_ChIP-Seq_LS180_Human1.01430499
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01177898
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.00990757
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00171154
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00058670
143AR_20517297_ChIP-Seq_VCAP_Human0.98760268
144* RUNX2_22187159_ChIP-Seq_PCA_Human0.98142278
145PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97484146
146PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97456964
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97419218
148EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97248370
149GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96994160
150CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93743855
151ELK3_25401928_ChIP-Seq_HUVEC_Human0.93250242
152BP1_19119308_ChIP-ChIP_Hs578T_Human0.90883078
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88853277
154GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87975841
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.87910319
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85539623
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82802453
158FOXP3_21729870_ChIP-Seq_TREG_Human0.82628627
159FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80840551
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.80394738
161CIITA_25753668_ChIP-Seq_RAJI_Human0.80083365
162FOXM1_23109430_ChIP-Seq_U2OS_Human0.78833373
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78502769
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77838730
165PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76722769
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.74857235
167* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73498741
168SPI1_20517297_ChIP-Seq_HL60_Human0.71613641
169RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70178471
170GABP_17652178_ChIP-ChIP_JURKAT_Human0.67899391
171VDR_24787735_ChIP-Seq_THP-1_Human0.67709005
172ELK1_19687146_ChIP-ChIP_HELA_Human0.63396854
173PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.63100088
174BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63029392
175GATA2_19941826_ChIP-Seq_K562_Human0.62879770
176LXR_22292898_ChIP-Seq_THP-1_Human0.62393122
177ETS1_22383799_ChIP-Seq_G1ME_Mouse0.61729467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.75768553
2MP0003763_abnormal_thymus_physiology4.54669835
3MP0001835_abnormal_antigen_presentation3.99138023
4MP0009785_altered_susceptibility_to3.71899417
5MP0006082_CNS_inflammation3.49875604
6MP0000569_abnormal_digit_pigmentation3.47743310
7MP0000685_abnormal_immune_system3.38203306
8MP0001800_abnormal_humoral_immune3.28812619
9MP0002420_abnormal_adaptive_immunity3.14915088
10MP0001819_abnormal_immune_cell3.13521492
11MP0005025_abnormal_response_to3.06771546
12MP0002723_abnormal_immune_serum2.99147200
13MP0005000_abnormal_immune_tolerance2.98006303
14MP0005387_immune_system_phenotype2.97866705
15MP0001790_abnormal_immune_system2.97866705
16MP0002166_altered_tumor_susceptibility2.84030456
17MP0002398_abnormal_bone_marrow2.82932111
18MP0002452_abnormal_antigen_presenting2.72798724
19MP0002006_tumorigenesis2.62744751
20MP0000716_abnormal_immune_system2.52092955
21MP0009333_abnormal_splenocyte_physiolog2.50604556
22MP0000703_abnormal_thymus_morphology2.40871568
23MP0002722_abnormal_immune_system2.34198924
24MP0002405_respiratory_system_inflammati2.32098312
25MP0003195_calcinosis2.28440506
26MP0000858_altered_metastatic_potential2.27206685
27MP0003448_altered_tumor_morphology2.26711475
28MP0003436_decreased_susceptibility_to2.24860365
29MP0002148_abnormal_hypersensitivity_rea2.20743933
30MP0003646_muscle_fatigue2.20306123
31MP0003724_increased_susceptibility_to2.15283508
32MP0000689_abnormal_spleen_morphology2.14757811
33MP0001873_stomach_inflammation2.13965781
34MP0002419_abnormal_innate_immunity2.10414931
35MP0004947_skin_inflammation2.10039939
36MP0002429_abnormal_blood_cell2.01088296
37MP0002009_preneoplasia1.94960161
38MP0010155_abnormal_intestine_physiology1.93821875
39MP0003866_abnormal_defecation1.89452286
40MP0001986_abnormal_taste_sensitivity1.88996348
41MP0005464_abnormal_platelet_physiology1.85462424
42MP0002933_joint_inflammation1.79477528
43MP0001501_abnormal_sleep_pattern1.78340932
44MP0001845_abnormal_inflammatory_respons1.72736539
45MP0004381_abnormal_hair_follicle1.65228233
46MP0010234_abnormal_vibrissa_follicle1.63602334
47MP0002396_abnormal_hematopoietic_system1.58577751
48MP0002876_abnormal_thyroid_physiology1.56186450
49MP0002132_abnormal_respiratory_system1.54918653
50MP0005551_abnormal_eye_electrophysiolog1.52773438
51MP0003045_fibrosis1.48224397
52MP0004510_myositis1.45117133
53MP0004130_abnormal_muscle_cell1.43437978
54MP0008877_abnormal_DNA_methylation1.41880442
55MP0006054_spinal_hemorrhage1.36936973
56MP0004043_abnormal_pH_regulation1.36649638
57MP0004142_abnormal_muscle_tone1.34898859
58MP0008469_abnormal_protein_level1.33989424
59MP0001968_abnormal_touch/_nociception1.33651028
60MP0001853_heart_inflammation1.33067249
61MP0003787_abnormal_imprinting1.32601439
62MP0003300_gastrointestinal_ulcer1.31140763
63MP0008872_abnormal_physiological_respon1.29614013
64MP0002163_abnormal_gland_morphology1.28814322
65MP0000427_abnormal_hair_cycle1.24522946
66MP0005075_abnormal_melanosome_morpholog1.17948142
67MP0002019_abnormal_tumor_incidence1.14550614
68MP0002837_dystrophic_cardiac_calcinosis1.14389930
69MP0002998_abnormal_bone_remodeling1.13063306
70MP0005645_abnormal_hypothalamus_physiol1.12450034
71MP0001851_eye_inflammation1.11682658
72MP0000490_abnormal_crypts_of1.10701970
73MP0009745_abnormal_behavioral_response1.09056830
74MP0005310_abnormal_salivary_gland1.06688674
75MP0003252_abnormal_bile_duct1.04723920
76MP0003303_peritoneal_inflammation1.00720656
77MP0002277_abnormal_respiratory_mucosa1.00376589
78MP0002102_abnormal_ear_morphology0.99828072
79MP0000015_abnormal_ear_pigmentation0.95212858
80MP0001485_abnormal_pinna_reflex0.94374693
81MP0001533_abnormal_skeleton_physiology0.93617382
82MP0005174_abnormal_tail_pigmentation0.92145351
83MP0009046_muscle_twitch0.91308959
84MP0005253_abnormal_eye_physiology0.88750710
85MP0001919_abnormal_reproductive_system0.88538779
86MP0009763_increased_sensitivity_to0.88240674
87MP0000465_gastrointestinal_hemorrhage0.87251578
88MP0000372_irregular_coat_pigmentation0.86706670
89MP0004145_abnormal_muscle_electrophysio0.86156376
90MP0003690_abnormal_glial_cell0.84843809
91MP0002138_abnormal_hepatobiliary_system0.84187732
92MP0005646_abnormal_pituitary_gland0.83171354
93MP0005377_hearing/vestibular/ear_phenot0.81004324
94MP0003878_abnormal_ear_physiology0.81004324
95MP0002736_abnormal_nociception_after0.80056581
96MP0005379_endocrine/exocrine_gland_phen0.79682947
97MP0003453_abnormal_keratinocyte_physiol0.79525933
98MP0004808_abnormal_hematopoietic_stem0.78671668
99MP0005389_reproductive_system_phenotype0.78671079
100MP0004742_abnormal_vestibular_system0.76992487
101MP0000604_amyloidosis0.76742801
102MP0005085_abnormal_gallbladder_physiolo0.76191770
103MP0002638_abnormal_pupillary_reflex0.75442408
104MP0000230_abnormal_systemic_arterial0.74534491
105MP0005167_abnormal_blood-brain_barrier0.74465761
106MP0002168_other_aberrant_phenotype0.73832681
107MP0000371_diluted_coat_color0.72608415
108MP0010307_abnormal_tumor_latency0.71875449
109MP0004883_abnormal_blood_vessel0.71458690
110MP0000470_abnormal_stomach_morphology0.71091977
111MP0009764_decreased_sensitivity_to0.70438048
112MP0000343_altered_response_to0.70090456
113MP0001243_abnormal_dermal_layer0.69737334
114MP0003329_amyloid_beta_deposits0.68193484
115MP0003136_yellow_coat_color0.68031793
116MP0005410_abnormal_fertilization0.67915245
117MP0002136_abnormal_kidney_physiology0.65535785
118MP0002272_abnormal_nervous_system0.65431438
119MP0008873_increased_physiological_sensi0.64100558
120MP0005166_decreased_susceptibility_to0.64063894
121MP0005023_abnormal_wound_healing0.61740843
122MP0008057_abnormal_DNA_replication0.60226684
123MP0010352_gastrointestinal_tract_polyps0.58160728
124MP0009765_abnormal_xenobiotic_induced0.58156866
125MP0001216_abnormal_epidermal_layer0.53211844
126MP0002095_abnormal_skin_pigmentation0.52957616
127MP0003795_abnormal_bone_structure0.51072720
128MP0000249_abnormal_blood_vessel0.49585179
129MP0000609_abnormal_liver_physiology0.48836134
130MP0000377_abnormal_hair_follicle0.48343230
131MP0004957_abnormal_blastocyst_morpholog0.47318026
132MP0001191_abnormal_skin_condition0.46746467
133MP0000477_abnormal_intestine_morphology0.45799366
134MP0000367_abnormal_coat/_hair0.45555454
135MP0003172_abnormal_lysosome_physiology0.42781381
136MP0003183_abnormal_peptide_metabolism0.42668121
137MP0009643_abnormal_urine_homeostasis0.42351528
138MP0000920_abnormal_myelination0.41365453
139MP0001881_abnormal_mammary_gland0.41361774
140MP0003950_abnormal_plasma_membrane0.40453543
141MP0008961_abnormal_basal_metabolism0.39925459
142MP0005408_hypopigmentation0.39441452
143MP0003077_abnormal_cell_cycle0.38726398
144MP0005451_abnormal_body_composition0.37364723
145MP0002083_premature_death0.35959316
146MP0002928_abnormal_bile_duct0.34395021
147MP0000627_abnormal_mammary_gland0.34174843
148MP0002693_abnormal_pancreas_physiology0.33914912

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.73718293
2Abnormality of T cell number (HP:0011839)6.42812867
3Elevated erythrocyte sedimentation rate (HP:0003565)6.30946382
4Myositis (HP:0100614)5.85332406
5Optic neuritis (HP:0100653)5.51762903
6Retrobulbar optic neuritis (HP:0100654)5.51762903
7Orchitis (HP:0100796)4.93349870
8Nasal polyposis (HP:0100582)4.86709805
9Eczematoid dermatitis (HP:0000976)4.85150253
10Abnormality of T cells (HP:0002843)4.79317172
11Encephalitis (HP:0002383)4.67406430
12Severe combined immunodeficiency (HP:0004430)4.64123575
13Panhypogammaglobulinemia (HP:0003139)4.64097690
14Combined immunodeficiency (HP:0005387)4.55542617
15Recurrent abscess formation (HP:0002722)4.38177349
16Recurrent fungal infections (HP:0002841)4.33128157
17Recurrent viral infections (HP:0004429)4.17896403
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.14470119
19Meningitis (HP:0001287)4.10957577
20Stomatitis (HP:0010280)4.07016503
21Recurrent cutaneous fungal infections (HP:0011370)4.04923652
22Chronic mucocutaneous candidiasis (HP:0002728)4.04923652
23Keratoconjunctivitis sicca (HP:0001097)4.03661660
24Abnormality of the nasal mucosa (HP:0000433)3.97174008
25Autoimmune hemolytic anemia (HP:0001890)3.95584755
26Pancreatic cysts (HP:0001737)3.74323921
27Chronic otitis media (HP:0000389)3.74083156
28IgM deficiency (HP:0002850)3.68346082
29Gastrointestinal infarctions (HP:0005244)3.66194164
30IgG deficiency (HP:0004315)3.65768000
31Keratoconjunctivitis (HP:0001096)3.64918705
32Recurrent bacterial skin infections (HP:0005406)3.64296040
33Recurrent bronchitis (HP:0002837)3.58026181
34Genetic anticipation (HP:0003743)3.45235761
35Joint swelling (HP:0001386)3.45055933
36Increased IgM level (HP:0003496)3.39936268
37Gaze-evoked nystagmus (HP:0000640)3.34087698
38Recurrent skin infections (HP:0001581)3.29168842
39Congenital stationary night blindness (HP:0007642)3.24032491
40Abnormality of T cell physiology (HP:0011840)3.20108547
41Hemoptysis (HP:0002105)3.13387182
42Pulmonary infiltrates (HP:0002113)3.13198059
43Leukocytosis (HP:0001974)3.07558256
44Arterial thrombosis (HP:0004420)3.06582686
45Agammaglobulinemia (HP:0004432)3.04830316
46Attenuation of retinal blood vessels (HP:0007843)3.04102206
47Lymphopenia (HP:0001888)3.03013210
48Mediastinal lymphadenopathy (HP:0100721)3.01059453
49Inflammation of the large intestine (HP:0002037)2.97750739
50Vasculitis (HP:0002633)2.96537826
51Stomach cancer (HP:0012126)2.88718696
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.88165579
53Abnormality of eosinophils (HP:0001879)2.87393085
54Obstructive lung disease (HP:0006536)2.86084072
55Chronic obstructive pulmonary disease (HP:0006510)2.86084072
56Pancreatic fibrosis (HP:0100732)2.83551501
57Hypoproteinemia (HP:0003075)2.83139041
58Progressive cerebellar ataxia (HP:0002073)2.82622035
59Abnormality of the renal cortex (HP:0011035)2.80128641
60Pustule (HP:0200039)2.80000410
61Gastrointestinal inflammation (HP:0004386)2.78338302
62Abnormality of macrophages (HP:0004311)2.78119430
63Clumsiness (HP:0002312)2.76694839
64True hermaphroditism (HP:0010459)2.76624101
65Abolished electroretinogram (ERG) (HP:0000550)2.67050291
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66843022
67Hypergammaglobulinemia (HP:0010702)2.66611825
68Thyroiditis (HP:0100646)2.65899085
69Increased IgE level (HP:0003212)2.64805169
70Abnormality of midbrain morphology (HP:0002418)2.61820723
71Molar tooth sign on MRI (HP:0002419)2.61820723
72Pulmonary embolism (HP:0002204)2.61556412
73Eosinophilia (HP:0001880)2.57578867
74Hyperventilation (HP:0002883)2.56039718
75Spontaneous hematomas (HP:0007420)2.55449665
76Spondylolisthesis (HP:0003302)2.52987190
77Thrombocytosis (HP:0001894)2.52941730
78Decreased electroretinogram (ERG) amplitude (HP:0000654)2.51010416
79Syringomyelia (HP:0003396)2.46003407
80Spinal cord lesions (HP:0100561)2.46003407
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.45748858
82Gangrene (HP:0100758)2.43814186
83Abnormality of the prostate (HP:0008775)2.43178966
84Metaphyseal dysplasia (HP:0100255)2.42878406
85Chronic diarrhea (HP:0002028)2.41228434
86Chest pain (HP:0100749)2.39219332
87Absent frontal sinuses (HP:0002688)2.39056455
88Abnormality of the fingertips (HP:0001211)2.31795273
89Type II lissencephaly (HP:0007260)2.29125677
90Diplopia (HP:0000651)2.27778742
91Abnormality of binocular vision (HP:0011514)2.27778742
92Colitis (HP:0002583)2.26270414
93Lymphoma (HP:0002665)2.26257118
94Granulocytopenia (HP:0001913)2.24994083
95Recurrent gram-negative bacterial infections (HP:0005420)2.24766663
96Hemiplegia (HP:0002301)2.21241951
97Progressive inability to walk (HP:0002505)2.18173453
98Chronic hepatic failure (HP:0100626)2.15807410
99Recurrent sinusitis (HP:0011108)2.15070066
100Cystic liver disease (HP:0006706)2.14579578
101Nephronophthisis (HP:0000090)2.14404363
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14191222
103Anorexia (HP:0002039)2.14180706
104Cerebellar dysplasia (HP:0007033)2.12837959
105Hypochromic anemia (HP:0001931)2.10955067
106Gingivitis (HP:0000230)2.10506242
107Keratitis (HP:0000491)2.09726546
108Febrile seizures (HP:0002373)2.09588492
109Abnormality of the renal medulla (HP:0100957)2.08846709
110Epistaxis (HP:0000421)2.06771808
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06630731
112Autoimmune thrombocytopenia (HP:0001973)2.04282878
113Abnormal rod and cone electroretinograms (HP:0008323)2.03703437
114Abnormality of the pleura (HP:0002103)2.03242906
115Increased corneal curvature (HP:0100692)2.02911231
116Keratoconus (HP:0000563)2.02911231
117Renal cortical cysts (HP:0000803)2.02590551
118Abnormality of B cell number (HP:0010975)2.01559935
119Congenital sensorineural hearing impairment (HP:0008527)1.99076718
120Abnormality of oral frenula (HP:0000190)1.96379051
121Frequent falls (HP:0002359)1.94606620
122Hypoalbuminemia (HP:0003073)1.93805921
123Abnormal albumin level (HP:0012116)1.93805921
124Glomerulopathy (HP:0100820)1.93715307
125Abnormal drinking behavior (HP:0030082)1.93381765
126Polydipsia (HP:0001959)1.93381765
127Recurrent otitis media (HP:0000403)1.93228041
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.92759988
129Absent/shortened dynein arms (HP:0200106)1.92759988
130Inability to walk (HP:0002540)1.91987990
131Protruding tongue (HP:0010808)1.91502084
132Constricted visual fields (HP:0001133)1.91319935
133Decreased circulating renin level (HP:0003351)1.91162716
134Polyneuropathy (HP:0001271)1.90433266
135Abnormality of the endocardium (HP:0004306)1.90231950
136Generalized hypopigmentation of hair (HP:0011358)1.89760464
137Bronchitis (HP:0012387)1.88071334
138Hypoplasia of the pons (HP:0012110)1.87907650
139Fair hair (HP:0002286)1.87896121
140Increased cerebral lipofuscin (HP:0011813)1.86491101
141Hematochezia (HP:0002573)1.85769002
142Decreased central vision (HP:0007663)1.85240625
143Facial diplegia (HP:0001349)1.85122651
144Bony spicule pigmentary retinopathy (HP:0007737)1.83843493
145Abnormality of the pons (HP:0007361)1.82797757
146Prolonged bleeding time (HP:0003010)1.81543058
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80816479
148Amyotrophic lateral sclerosis (HP:0007354)1.78905365
149Hypoplasia of the thymus (HP:0000778)1.78341175
150Verrucae (HP:0200043)1.78254270
151Papilloma (HP:0012740)1.78254270
152Hepatitis (HP:0012115)1.76852905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.10127116
2TXK6.30067390
3MAP4K14.92963336
4ITK3.50210119
5ZAP703.33029077
6JAK33.27177387
7ACVR1B3.15701374
8TYK22.57489652
9IRAK42.45253296
10STK102.37642212
11IKBKE2.29695880
12MAP3K142.29180202
13JAK12.28750570
14GRK62.12750150
15BMPR1B2.11029407
16FGFR42.08578552
17LCK2.05445858
18TESK22.00741195
19CSK1.98998135
20MST41.93814817
21TBK11.92882548
22BLK1.88411440
23TEC1.79992631
24BTK1.69500799
25MAP3K121.68747240
26CLK11.60294651
27MAP3K131.57090614
28PIK3CG1.51813483
29GRK11.45309793
30SYK1.41645657
31RIPK41.39485196
32NUAK11.39418914
33KDR1.38224816
34ZAK1.37336558
35FGFR31.36249430
36INSRR1.34525446
37CAMKK21.31232287
38KIT1.30448338
39NLK1.27429604
40PTK2B1.22599671
41MAP2K61.18920893
42MAPK131.18567878
43SRPK11.18395250
44ADRBK11.17664738
45HCK1.14723473
46LRRK21.13951091
47PRKD21.13672761
48IKBKB1.12972289
49TLK11.12388543
50PRKCQ1.10871682
51RPS6KA41.09868783
52AKT31.07493962
53TNK21.05587751
54IRAK31.04179121
55PIM11.00232473
56FES1.00162890
57LYN0.97967474
58GRK70.97182788
59MAP4K20.95564604
60NEK90.94870781
61WNK30.90940560
62OXSR10.90794722
63FLT30.89165283
64PRKCH0.88685033
65MAP3K100.84701167
66CSF1R0.82644173
67PINK10.82036513
68WNK40.81085308
69PIK3CA0.77235453
70TAOK30.77002386
71MARK30.73069425
72JAK20.71878333
73CDK30.71374667
74ADRBK20.71054224
75NME20.69288566
76MUSK0.68232533
77SIK20.67210252
78SGK20.66338251
79TGFBR20.63078763
80STK380.61801576
81HIPK20.60960089
82GRK50.60137308
83NTRK30.59688943
84CHUK0.59593523
85STK390.59112586
86PAK30.57737762
87STK110.57178509
88EEF2K0.56360783
89CAMKK10.54416654
90TRPM70.54281795
91MAP3K40.53350977
92BMPR20.52798369
93SIK30.51832891
94MAP3K80.50747410
95IRAK10.49494860
96TGFBR10.49105701
97RPS6KA60.48740702
98FYN0.47419320
99CDK40.46178096
100DAPK20.46089136
101MYLK0.45894487
102EPHB10.45608773
103TAOK10.43647951
104PDK10.42498161
105RPS6KC10.41817647
106RPS6KL10.41817647
107PRKCE0.41788108
108IGF1R0.40913316
109TYRO30.40451261
110MAP3K70.39866272
111INSR0.38700019
112STK240.37048770
113IRAK20.37040278
114TTN0.36947914
115ERBB20.34203259
116PRKAA20.34154659
117CAMK10.33503008
118NEK20.32113721
119MAPKAPK30.31977789
120OBSCN0.31006129
121ABL10.30371201
122SGK2230.29089318
123SGK4940.29089318
124MAP2K30.28844827
125MAPK110.28746208
126CSNK1D0.28707045
127MAPKAPK20.27965060
128PKN10.27902119
129TESK10.27610715
130BUB10.26343209
131MAPK40.26232298
132MELK0.26065573
133EPHA30.25935087
134PDGFRB0.25240715
135FGFR10.25194199
136STK40.25058061
137MARK20.25030382
138PRKCD0.24070238
139TSSK60.24025218
140CDK90.21960314
141DMPK0.21589511
142RAF10.21274432
143FGR0.19989452

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053326.29305876
2Primary immunodeficiency_Homo sapiens_hsa053405.07090121
3* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.79278884
4* Antigen processing and presentation_Homo sapiens_hsa046124.13779322
5T cell receptor signaling pathway_Homo sapiens_hsa046603.29515866
6Allograft rejection_Homo sapiens_hsa053303.03583102
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.92185645
8Measles_Homo sapiens_hsa051622.62294088
9Viral myocarditis_Homo sapiens_hsa054162.22830842
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.15101063
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.04095630
12Autoimmune thyroid disease_Homo sapiens_hsa053202.01858964
13Hematopoietic cell lineage_Homo sapiens_hsa046402.01160721
14Leishmaniasis_Homo sapiens_hsa051401.96169881
15Phototransduction_Homo sapiens_hsa047441.82775214
16Linoleic acid metabolism_Homo sapiens_hsa005911.80139134
17Nitrogen metabolism_Homo sapiens_hsa009101.79990986
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73911540
19Osteoclast differentiation_Homo sapiens_hsa043801.62433250
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61665625
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61471918
22Type I diabetes mellitus_Homo sapiens_hsa049401.59028172
23B cell receptor signaling pathway_Homo sapiens_hsa046621.58855750
24Ribosome_Homo sapiens_hsa030101.51005616
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.49855478
26ABC transporters_Homo sapiens_hsa020101.49422054
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.46172793
28Chemokine signaling pathway_Homo sapiens_hsa040621.46156371
29Herpes simplex infection_Homo sapiens_hsa051681.36128293
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34217423
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32556147
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27175320
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.20545455
34Morphine addiction_Homo sapiens_hsa050321.19812203
35Toxoplasmosis_Homo sapiens_hsa051451.19319706
36Shigellosis_Homo sapiens_hsa051311.17455535
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16910215
38Malaria_Homo sapiens_hsa051441.16530324
39Dorso-ventral axis formation_Homo sapiens_hsa043201.16116870
40Nicotine addiction_Homo sapiens_hsa050331.12101769
41Apoptosis_Homo sapiens_hsa042101.12015710
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11728578
43Ether lipid metabolism_Homo sapiens_hsa005651.10432509
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07630286
45Taste transduction_Homo sapiens_hsa047421.07004923
46Olfactory transduction_Homo sapiens_hsa047401.05893719
47Butanoate metabolism_Homo sapiens_hsa006501.03685313
48Tryptophan metabolism_Homo sapiens_hsa003801.03110702
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00109936
50Staphylococcus aureus infection_Homo sapiens_hsa051500.99827402
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98707364
52Influenza A_Homo sapiens_hsa051640.97795099
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97754315
54Hepatitis B_Homo sapiens_hsa051610.96599842
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96554906
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94749453
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94127003
58Platelet activation_Homo sapiens_hsa046110.93162545
59HTLV-I infection_Homo sapiens_hsa051660.93124674
60Glycerolipid metabolism_Homo sapiens_hsa005610.93027549
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.90551369
62Tuberculosis_Homo sapiens_hsa051520.90148198
63Pancreatic cancer_Homo sapiens_hsa052120.88054157
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.80691613
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79371615
66Calcium signaling pathway_Homo sapiens_hsa040200.79046849
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78484482
68TNF signaling pathway_Homo sapiens_hsa046680.76316634
69Acute myeloid leukemia_Homo sapiens_hsa052210.75700554
70Epstein-Barr virus infection_Homo sapiens_hsa051690.75433322
71Regulation of autophagy_Homo sapiens_hsa041400.74515028
72VEGF signaling pathway_Homo sapiens_hsa043700.74514614
73Colorectal cancer_Homo sapiens_hsa052100.73303926
74African trypanosomiasis_Homo sapiens_hsa051430.72127561
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72111529
76Pertussis_Homo sapiens_hsa051330.70853260
77Serotonergic synapse_Homo sapiens_hsa047260.70444845
78Salivary secretion_Homo sapiens_hsa049700.69655189
79Ovarian steroidogenesis_Homo sapiens_hsa049130.69627268
80Circadian entrainment_Homo sapiens_hsa047130.69450451
81Arachidonic acid metabolism_Homo sapiens_hsa005900.69408258
82Hepatitis C_Homo sapiens_hsa051600.69053460
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.67541239
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65583882
85Salmonella infection_Homo sapiens_hsa051320.62051848
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61798481
87Chemical carcinogenesis_Homo sapiens_hsa052040.60452110
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.60178354
89Glutamatergic synapse_Homo sapiens_hsa047240.59536632
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58959997
91Homologous recombination_Homo sapiens_hsa034400.58869132
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57722668
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57352195
94Cholinergic synapse_Homo sapiens_hsa047250.56569424
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.56494364
96Retinol metabolism_Homo sapiens_hsa008300.56074763
97Rheumatoid arthritis_Homo sapiens_hsa053230.55196070
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.52520347
99Legionellosis_Homo sapiens_hsa051340.52384033
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.51230340
101GABAergic synapse_Homo sapiens_hsa047270.51198519
102Selenocompound metabolism_Homo sapiens_hsa004500.51002667
103p53 signaling pathway_Homo sapiens_hsa041150.50423188
104Oxytocin signaling pathway_Homo sapiens_hsa049210.50263695
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49871992
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.49757839
107cAMP signaling pathway_Homo sapiens_hsa040240.49486097
108DNA replication_Homo sapiens_hsa030300.48816280
109Endocytosis_Homo sapiens_hsa041440.48476425
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48462020
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47278874
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45093241
113Viral carcinogenesis_Homo sapiens_hsa052030.43237619
114Asthma_Homo sapiens_hsa053100.42309101
115Gastric acid secretion_Homo sapiens_hsa049710.41880530
116Renin secretion_Homo sapiens_hsa049240.41441705
117Type II diabetes mellitus_Homo sapiens_hsa049300.41187224
118Histidine metabolism_Homo sapiens_hsa003400.41035025
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40690999
120Chronic myeloid leukemia_Homo sapiens_hsa052200.40305380
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40156649
122Insulin secretion_Homo sapiens_hsa049110.38709009
123Small cell lung cancer_Homo sapiens_hsa052220.36432809
124Adherens junction_Homo sapiens_hsa045200.34881083
125Spliceosome_Homo sapiens_hsa030400.32000684
126Non-small cell lung cancer_Homo sapiens_hsa052230.29171912
127RNA degradation_Homo sapiens_hsa030180.28274867
128Mismatch repair_Homo sapiens_hsa034300.27271134
129Other glycan degradation_Homo sapiens_hsa005110.25704050
130Prolactin signaling pathway_Homo sapiens_hsa049170.25068896
131Rap1 signaling pathway_Homo sapiens_hsa040150.24724913
132Base excision repair_Homo sapiens_hsa034100.21974878
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21801481
134FoxO signaling pathway_Homo sapiens_hsa040680.20407266
135Notch signaling pathway_Homo sapiens_hsa043300.16616580
136Lysosome_Homo sapiens_hsa041420.15899729
137Caffeine metabolism_Homo sapiens_hsa002320.15674048
138Focal adhesion_Homo sapiens_hsa045100.15198703
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14948993
140MAPK signaling pathway_Homo sapiens_hsa040100.14104383
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13279368
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12863007
143Insulin resistance_Homo sapiens_hsa049310.10358083
144Pathways in cancer_Homo sapiens_hsa052000.09244589
145Pentose phosphate pathway_Homo sapiens_hsa000300.08792213
146Inositol phosphate metabolism_Homo sapiens_hsa005620.08040988
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.05780219
148Choline metabolism in cancer_Homo sapiens_hsa052310.05700389
149Proteasome_Homo sapiens_hsa030500.05420370
150Prostate cancer_Homo sapiens_hsa052150.05275429
151Nucleotide excision repair_Homo sapiens_hsa034200.04478101
152Endometrial cancer_Homo sapiens_hsa052130.01916820
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01727868
154Ras signaling pathway_Homo sapiens_hsa040140.00661106
155mRNA surveillance pathway_Homo sapiens_hsa030150.00432809

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