KLRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)9.63419522
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.63419522
3interferon-gamma production (GO:0032609)7.76267728
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.98050338
5cellular response to interleukin-15 (GO:0071350)6.67375531
6response to interleukin-15 (GO:0070672)6.26278444
7positive regulation of gamma-delta T cell activation (GO:0046645)5.68570739
8negative thymic T cell selection (GO:0045060)5.66157040
9regulation of B cell receptor signaling pathway (GO:0050855)5.60434579
10regulation of natural killer cell mediated immunity (GO:0002715)5.51157494
11regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.51157494
12negative T cell selection (GO:0043383)5.45473221
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.36759198
14antigen processing and presentation of endogenous antigen (GO:0019883)5.08466189
15negative regulation of lymphocyte mediated immunity (GO:0002707)5.08027823
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.71372295
17regulation of gamma-delta T cell differentiation (GO:0045586)4.62316889
18negative regulation of leukocyte mediated immunity (GO:0002704)4.53606719
19leukocyte aggregation (GO:0070486)4.50514882
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49385075
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45113950
22regulation of gamma-delta T cell activation (GO:0046643)4.44674696
23regulation of leukocyte mediated cytotoxicity (GO:0001910)4.39492073
24neutrophil activation involved in immune response (GO:0002283)4.21933636
25positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.19007934
26cellular defense response (GO:0006968)4.15821872
27positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.11657204
28cellular extravasation (GO:0045123)4.07516913
29negative regulation of type 2 immune response (GO:0002829)4.05743935
30regulation of cell killing (GO:0031341)3.93537417
31T cell selection (GO:0045058)3.90633668
32regulation of T cell mediated cytotoxicity (GO:0001914)3.86674531
33regulation of isotype switching to IgG isotypes (GO:0048302)3.86201130
34positive thymic T cell selection (GO:0045059)3.85020500
35positive regulation of T cell mediated cytotoxicity (GO:0001916)3.80428541
36positive regulation of mast cell activation (GO:0033005)3.79316007
37antigen processing and presentation via MHC class Ib (GO:0002475)3.75349305
38T cell migration (GO:0072678)3.74798288
39thymic T cell selection (GO:0045061)3.74259181
40regulation of B cell differentiation (GO:0045577)3.73188778
41activated T cell proliferation (GO:0050798)3.72134509
42macrophage activation involved in immune response (GO:0002281)3.70603831
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68433217
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.68433217
45modulation by symbiont of host immune response (GO:0052553)3.68433217
46positive regulation by symbiont of host defense response (GO:0052509)3.68433217
47modulation by symbiont of host defense response (GO:0052031)3.68433217
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68433217
49B cell receptor signaling pathway (GO:0050853)3.66104753
50positive regulation of cell killing (GO:0031343)3.65648062
51negative regulation of innate immune response (GO:0045824)3.64583298
52negative regulation of T cell mediated immunity (GO:0002710)3.64299620
53regulation of mast cell degranulation (GO:0043304)3.58107712
54regulation of alpha-beta T cell proliferation (GO:0046640)3.53343640
55response to muramyl dipeptide (GO:0032495)3.50105583
56cellular response to type I interferon (GO:0071357)3.48315651
57type I interferon signaling pathway (GO:0060337)3.48315651
58neutrophil activation (GO:0042119)3.45617637
59mast cell activation (GO:0045576)3.45056361
60regulation of mast cell activation (GO:0033003)3.44510551
61response to type I interferon (GO:0034340)3.44264507
62positive T cell selection (GO:0043368)3.38709166
63rRNA catabolic process (GO:0016075)3.37264482
64B cell mediated immunity (GO:0019724)3.36735901
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34494519
66positive regulation of mast cell degranulation (GO:0043306)3.33056465
67positive regulation of mast cell activation involved in immune response (GO:0033008)3.33056465
68dendritic cell chemotaxis (GO:0002407)3.32662905
69negative regulation of phagocytosis (GO:0050765)3.31889661
70negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.31741589
71regulation of mast cell activation involved in immune response (GO:0033006)3.31138853
72natural killer cell activation (GO:0030101)3.30956880
73natural killer cell differentiation (GO:0001779)3.28596296
74regulation of lymphocyte mediated immunity (GO:0002706)3.25728743
75positive regulation of B cell differentiation (GO:0045579)3.25561006
76regulation of leukocyte mediated immunity (GO:0002703)3.20394279
77detection of other organism (GO:0098543)3.18954926
78myeloid cell activation involved in immune response (GO:0002275)3.17974604
79antigen receptor-mediated signaling pathway (GO:0050851)3.14520908
80positive regulation of T cell cytokine production (GO:0002726)3.13354168
81positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11829327
82detection of bacterium (GO:0016045)3.11685124
83leukocyte migration involved in inflammatory response (GO:0002523)3.11413345
84positive regulation of lymphocyte mediated immunity (GO:0002708)3.11411441
85interferon-gamma-mediated signaling pathway (GO:0060333)3.08700430
86negative regulation of bone resorption (GO:0045779)3.06762590
87granulocyte activation (GO:0036230)3.05332843
88positive regulation of cellular amide metabolic process (GO:0034250)3.03407241
89microglial cell activation (GO:0001774)3.03332421
90dendritic cell migration (GO:0036336)3.01672259
91negative regulation of alpha-beta T cell activation (GO:0046636)3.00319169
92regulation of T cell mediated immunity (GO:0002709)3.00228539
93positive regulation of leukocyte mediated immunity (GO:0002705)3.00220898
94positive regulation of T cell mediated immunity (GO:0002711)2.99469200
95regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98573368
96negative regulation of DNA-templated transcription, elongation (GO:0032785)2.92958444
97regulation of regulatory T cell differentiation (GO:0045589)2.92896248
98regulation of interferon-beta biosynthetic process (GO:0045357)2.92462688
99negative regulation of T-helper cell differentiation (GO:0045623)2.91406615
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91406615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.59155998
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.34004771
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.84904266
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.94645075
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.87240438
6RUNX_20019798_ChIP-Seq_JUKART_Human3.84099339
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60990810
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.58082822
9MYB_26560356_Chip-Seq_TH2_Human3.17228618
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13184204
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.12097631
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87353312
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.82574769
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.67205817
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67203922
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57068527
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46516275
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.43102781
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40392457
20MYB_26560356_Chip-Seq_TH1_Human2.36091239
21SPI1_23547873_ChIP-Seq_NB4_Human2.31349331
22RUNX1_22412390_ChIP-Seq_EML_Mouse2.29100498
23LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25813127
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25319630
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24140696
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21609541
27UTX_26944678_Chip-Seq_JUKART_Human2.19438331
28MAF_26560356_Chip-Seq_TH1_Human2.19164278
29SPI1_23127762_ChIP-Seq_K562_Human2.18228862
30SCL_19346495_ChIP-Seq_HPC-7_Human2.16967437
31GATA3_27048872_Chip-Seq_THYMUS_Human2.15597589
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15294028
33GATA3_26560356_Chip-Seq_TH2_Human2.09838706
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88301232
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84794248
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.80855021
37VDR_24763502_ChIP-Seq_THP-1_Human1.79735859
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.77271161
39MAF_26560356_Chip-Seq_TH2_Human1.72935955
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67001483
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63756934
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.58452686
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.52110182
44VDR_24787735_ChIP-Seq_THP-1_Human1.46171212
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.46156972
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44649221
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43945419
48VDR_21846776_ChIP-Seq_THP-1_Human1.42250475
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41602424
50MYC_22102868_ChIP-Seq_BL_Human1.41468999
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38161780
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.36234351
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26575839
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26300796
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26171762
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25300908
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24652148
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24052936
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22802503
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.22660136
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19943472
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19430004
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18217642
64PU_27001747_Chip-Seq_BMDM_Mouse1.17296702
65TCF7_22412390_ChIP-Seq_EML_Mouse1.16287945
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15759713
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14918571
68BCL6_27268052_Chip-Seq_Bcells_Human1.12673562
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11855707
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10125498
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07238080
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06311047
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06129013
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05759244
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01442480
76KDM2B_26808549_Chip-Seq_DND41_Human0.96855606
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96612402
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95430402
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95328521
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93608312
81CIITA_25753668_ChIP-Seq_RAJI_Human0.91974028
82GATA1_19941826_ChIP-Seq_K562_Human0.91702647
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89524377
84PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88214474
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88032739
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87794783
87GATA3_26560356_Chip-Seq_TH1_Human0.87736041
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87011827
89SPI1_20517297_ChIP-Seq_HL60_Human0.85686597
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82759366
91BCOR_27268052_Chip-Seq_Bcells_Human0.81152628
92GATA2_19941826_ChIP-Seq_K562_Human0.80946844
93STAT1_20625510_ChIP-Seq_HELA_Human0.80929222
94SMRT_27268052_Chip-Seq_Bcells_Human0.79298275
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77310273
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75369093
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74743701
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74690408
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73804531
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.73641954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.82919415
2MP0003724_increased_susceptibility_to4.46079015
3MP0003436_decreased_susceptibility_to4.10430534
4MP0001835_abnormal_antigen_presentation4.04844079
5MP0006082_CNS_inflammation4.01522571
6MP0000685_abnormal_immune_system3.57395936
7MP0005000_abnormal_immune_tolerance3.35395394
8MP0003763_abnormal_thymus_physiology3.29432457
9MP0001800_abnormal_humoral_immune3.26742833
10MP0005025_abnormal_response_to3.04603014
11MP0009785_altered_susceptibility_to2.96689130
12MP0001790_abnormal_immune_system2.87217506
13MP0005387_immune_system_phenotype2.87217506
14MP0002419_abnormal_innate_immunity2.85751251
15MP0002723_abnormal_immune_serum2.83708010
16MP0002420_abnormal_adaptive_immunity2.75576334
17MP0001819_abnormal_immune_cell2.73277219
18MP0002452_abnormal_antigen_presenting2.60475830
19MP0005464_abnormal_platelet_physiology2.30874009
20MP0002405_respiratory_system_inflammati2.26019531
21MP0002398_abnormal_bone_marrow2.19300653
22MP0004947_skin_inflammation2.17398417
23MP0002148_abnormal_hypersensitivity_rea2.13457173
24MP0000716_abnormal_immune_system2.05799576
25MP0001533_abnormal_skeleton_physiology2.05022349
26MP0000703_abnormal_thymus_morphology2.02288067
27MP0001986_abnormal_taste_sensitivity2.01004850
28MP0000465_gastrointestinal_hemorrhage2.00044774
29MP0002722_abnormal_immune_system1.88369923
30MP0000689_abnormal_spleen_morphology1.85351680
31MP0001845_abnormal_inflammatory_respons1.82945702
32MP0010155_abnormal_intestine_physiology1.80829124
33MP0002132_abnormal_respiratory_system1.73377069
34MP0009333_abnormal_splenocyte_physiolog1.63319340
35MP0005310_abnormal_salivary_gland1.62270042
36MP0002429_abnormal_blood_cell1.59770802
37MP0003303_peritoneal_inflammation1.58699443
38MP0003172_abnormal_lysosome_physiology1.58501674
39MP0000858_altered_metastatic_potential1.45323209
40MP0009764_decreased_sensitivity_to1.42990841
41MP0004381_abnormal_hair_follicle1.41392280
42MP0001851_eye_inflammation1.40075894
43MP0003866_abnormal_defecation1.38936809
44MP0008469_abnormal_protein_level1.38852255
45MP0001348_abnormal_lacrimal_gland1.37618699
46MP0004130_abnormal_muscle_cell1.31458277
47MP0002396_abnormal_hematopoietic_system1.31178749
48MP0002166_altered_tumor_susceptibility1.28086910
49MP0005075_abnormal_melanosome_morpholog1.28060765
50MP0003191_abnormal_cellular_cholesterol1.25677282
51MP0003448_altered_tumor_morphology1.20468047
52MP0001873_stomach_inflammation1.18913505
53MP0003300_gastrointestinal_ulcer1.18414963
54MP0004043_abnormal_pH_regulation1.18249112
55MP0003828_pulmonary_edema1.10960909
56MP0003690_abnormal_glial_cell1.07836768
57MP0006054_spinal_hemorrhage1.07346743
58MP0004883_abnormal_blood_vessel1.06817476
59MP0002006_tumorigenesis1.05100746
60MP0002163_abnormal_gland_morphology1.02314531
61MP0002009_preneoplasia1.01480018
62MP0002933_joint_inflammation1.00589663
63MP0009763_increased_sensitivity_to0.95492499
64MP0010307_abnormal_tumor_latency0.93100681
65MP0002998_abnormal_bone_remodeling0.89761469
66MP0009278_abnormal_bone_marrow0.84533062
67MP0003656_abnormal_erythrocyte_physiolo0.83618653
68MP0002876_abnormal_thyroid_physiology0.81992561
69MP0002019_abnormal_tumor_incidence0.80733026
70MP0005390_skeleton_phenotype0.79943315
71MP0000490_abnormal_crypts_of0.76518750
72MP0005164_abnormal_response_to0.76271920
73MP0004510_myositis0.75096139
74MP0008873_increased_physiological_sensi0.73140210
75MP0002693_abnormal_pancreas_physiology0.73017737
76MP0005166_decreased_susceptibility_to0.71351653
77MP0000015_abnormal_ear_pigmentation0.70848066
78MP0001853_heart_inflammation0.70287881
79MP0003183_abnormal_peptide_metabolism0.69132265
80MP0000249_abnormal_blood_vessel0.68495414
81MP0003045_fibrosis0.64998625
82MP0003252_abnormal_bile_duct0.61677336
83MP0009765_abnormal_xenobiotic_induced0.60293333
84MP0008260_abnormal_autophagy0.56515945
85MP0000569_abnormal_digit_pigmentation0.54932029
86MP0003638_abnormal_response/metabolism_0.54281557
87MP0002332_abnormal_exercise_endurance0.53730394
88MP0000920_abnormal_myelination0.53219855
89MP0003075_altered_response_to0.51645196
90MP0004142_abnormal_muscle_tone0.51512457
91MP0005319_abnormal_enzyme/_coenzyme0.51410934
92MP0001545_abnormal_hematopoietic_system0.51222736
93MP0005397_hematopoietic_system_phenotyp0.51222736
94MP0004484_altered_response_of0.50502082
95MP0000343_altered_response_to0.49394314
96MP0001663_abnormal_digestive_system0.48796708
97MP0001346_abnormal_lacrimal_gland0.47682559
98MP0001919_abnormal_reproductive_system0.45546633
99MP0008874_decreased_physiological_sensi0.44281909
100MP0002653_abnormal_ependyma_morphology0.43710270

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)6.29268911
2Retrobulbar optic neuritis (HP:0100654)6.09590270
3Optic neuritis (HP:0100653)6.09590270
4Orchitis (HP:0100796)5.88304159
5Encephalitis (HP:0002383)5.72438772
6Abnormal delayed hypersensitivity skin test (HP:0002963)5.49227202
7Eczematoid dermatitis (HP:0000976)5.03389048
8Abnormality of T cell number (HP:0011839)4.90427993
9Increased IgM level (HP:0003496)4.82889552
10Recurrent bacterial skin infections (HP:0005406)4.73202123
11Recurrent abscess formation (HP:0002722)4.64597395
12T lymphocytopenia (HP:0005403)4.50851247
13Abnormality of macrophages (HP:0004311)4.45117735
14Stomatitis (HP:0010280)4.42584589
15Recurrent fungal infections (HP:0002841)4.34521987
16Meningitis (HP:0001287)4.26261579
17Elevated erythrocyte sedimentation rate (HP:0003565)4.23880383
18IgG deficiency (HP:0004315)4.21134332
19Keratoconjunctivitis sicca (HP:0001097)4.20630172
20Keratoconjunctivitis (HP:0001096)4.16116278
21Abnormality of T cells (HP:0002843)4.07683564
22Eosinophilia (HP:0001880)3.97089752
23Pustule (HP:0200039)3.80191991
24Granulocytopenia (HP:0001913)3.75050708
25Hypoproteinemia (HP:0003075)3.74578154
26Abnormality of T cell physiology (HP:0011840)3.71184916
27Joint swelling (HP:0001386)3.69756745
28Hemoptysis (HP:0002105)3.64844560
29Panhypogammaglobulinemia (HP:0003139)3.61071969
30Hemiplegia (HP:0002301)3.58610019
31Abnormality of eosinophils (HP:0001879)3.49365064
32Recurrent cutaneous fungal infections (HP:0011370)3.48555044
33Chronic mucocutaneous candidiasis (HP:0002728)3.48555044
34Prolonged bleeding time (HP:0003010)3.38557029
35Leukocytosis (HP:0001974)3.38469403
36Vasculitis (HP:0002633)3.37035004
37Gastrointestinal infarctions (HP:0005244)3.35375615
38Recurrent skin infections (HP:0001581)3.34650046
39Pulmonary infiltrates (HP:0002113)3.25786345
40Arterial thrombosis (HP:0004420)3.24408651
41Anorexia (HP:0002039)3.11321134
42Recurrent gram-negative bacterial infections (HP:0005420)3.00958179
43Autoimmune thrombocytopenia (HP:0001973)2.98098397
44Mediastinal lymphadenopathy (HP:0100721)2.93030068
45Spontaneous hematomas (HP:0007420)2.91602788
46Chronic obstructive pulmonary disease (HP:0006510)2.89080510
47Obstructive lung disease (HP:0006536)2.89080510
48Chest pain (HP:0100749)2.85725792
49Inflammation of the large intestine (HP:0002037)2.82650673
50Increased serum ferritin (HP:0003281)2.78556283
51Severe combined immunodeficiency (HP:0004430)2.77073021
52Autoimmune hemolytic anemia (HP:0001890)2.76897568
53Gingival bleeding (HP:0000225)2.69467637
54Pulmonary embolism (HP:0002204)2.69460729
55Gastrointestinal inflammation (HP:0004386)2.64598573
56Gangrene (HP:0100758)2.62102879
57Hypochromic anemia (HP:0001931)2.61412968
58Epistaxis (HP:0000421)2.60227051
59Keratitis (HP:0000491)2.56496662
60Cheilitis (HP:0100825)2.50132675
61Abnormality of iron homeostasis (HP:0011031)2.45461235
62Abnormality of the endocardium (HP:0004306)2.45223718
63Glomerulopathy (HP:0100820)2.44346352
64Subacute progressive viral hepatitis (HP:0006572)2.37988159
65Urticaria (HP:0001025)2.36407266
66Recurrent viral infections (HP:0004429)2.34888199
67Hypergammaglobulinemia (HP:0010702)2.32816055
68Abnormality of the pleura (HP:0002103)2.31339338
69Colitis (HP:0002583)2.27672151
70Stomach cancer (HP:0012126)2.27409403
71Agammaglobulinemia (HP:0004432)2.25454636
72Viral hepatitis (HP:0006562)2.23715343
73Vertigo (HP:0002321)2.21924189
74Recurrent bronchitis (HP:0002837)2.21034251
75Increased CSF protein (HP:0002922)2.20346380
76Increased IgE level (HP:0003212)2.18587474
77Verrucae (HP:0200043)2.18333915
78Papilloma (HP:0012740)2.18333915
79Spondylolisthesis (HP:0003302)2.17454117
80Abnormality of the common coagulation pathway (HP:0010990)2.14009060
81Gingivitis (HP:0000230)2.12335303
82Abnormality of transition element cation homeostasis (HP:0011030)2.12079958
83Combined immunodeficiency (HP:0005387)2.10944631
84Chronic diarrhea (HP:0002028)2.09794825
85Fatigue (HP:0012378)2.08013006
86Facial diplegia (HP:0001349)2.00818560
87Acne (HP:0001061)1.99023203
88Abnormality of intracranial pressure (HP:0012640)1.96370408
89Increased intracranial pressure (HP:0002516)1.96370408
90Alveolar cell carcinoma (HP:0006519)1.94425080
91Conical tooth (HP:0000698)1.88841106
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.88034886
93Abnormal albumin level (HP:0012116)1.82833268
94Hypoalbuminemia (HP:0003073)1.82833268
95Neoplasm of the tracheobronchial system (HP:0100552)1.80823969
96Lymphoma (HP:0002665)1.79754652
97Tetraplegia (HP:0002445)1.77942313
98Hematochezia (HP:0002573)1.74045365
99Arthralgia (HP:0002829)1.73978372
100Thrombophlebitis (HP:0004418)1.73923140

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.34571931
2SIK24.07854497
3GRK63.82408035
4MAP4K13.32635683
5MAP3K142.89706136
6JAK32.64270808
7RIPK42.52314057
8FES2.49338585
9BTK1.99950113
10ZAP701.98387048
11CSK1.90972099
12TBK11.90896471
13BLK1.77133292
14IKBKE1.76323403
15JAK11.74661965
16TYK21.74107816
17ITK1.73077546
18STK101.67025180
19ACVR1B1.60873157
20MAP3K131.57520587
21TNK21.54466250
22IKBKB1.54263165
23TAOK31.50799049
24TEC1.49759062
25SYK1.48140636
26PRPF4B1.48065112
27LCK1.47933024
28IRAK41.39738100
29GRK71.39213032
30MAP2K61.37199574
31HCK1.35501160
32MAP2K31.34513081
33LYN1.31789793
34TGFBR21.29566241
35NEK21.29186677
36CDK31.27438813
37PIK3CG1.26200285
38KIT1.22237060
39MAP2K21.19189090
40CSF1R1.16914447
41SIK31.12994405
42NUAK11.07216832
43CAMKK21.06384591
44EPHB11.02555320
45FGR0.99181533
46BRD40.93970732
47JAK20.86776602
48PIM10.83289619
49MOS0.80790076
50MAP3K30.80311200
51TLK10.77475491
52MARK30.77318536
53ERN10.77018228
54RAF10.74180516
55PRKCQ0.73909142
56BMPR20.71855940
57BCR0.69381431
58KSR20.67809504
59MAPK70.67180404
60MAP3K20.65325025
61PDK10.65284605
62CDK40.60217497
63FYN0.59638996
64GRK50.57318754
65CAMKK10.55975905
66KDR0.53853471
67EIF2AK20.52923821
68PRKCH0.51153433
69CHUK0.49939275
70TESK20.47888637
71MAPK110.46204642
72IGF1R0.41121222
73STK240.40985594
74PTK2B0.40874097
75MAP3K70.39176062
76MAPK120.38816668
77KSR10.37766461
78MATK0.36892961
79MAP3K10.33748702
80ABL10.33741576
81PRKCD0.32545603
82STK380.32417771
83MAP3K110.31547007
84PTK60.31410876
85ADRBK20.30524771
86INSR0.30469101
87YES10.30015137
88MAPKAPK20.27999748
89MAPK130.27781191
90FGFR40.26705188
91RPS6KA60.26422400
92FGFR30.25554073
93SGK30.24621778
94MARK20.24520614
95TAOK10.22407394
96EGFR0.22371733
97STK110.20005635
98RPS6KL10.18561238
99RPS6KC10.18561238
100IRAK10.18267505

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.06210355
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.17607497
3Allograft rejection_Homo sapiens_hsa053303.37565929
4Antigen processing and presentation_Homo sapiens_hsa046123.27445797
5Autoimmune thyroid disease_Homo sapiens_hsa053203.18597419
6Primary immunodeficiency_Homo sapiens_hsa053402.72102255
7Leishmaniasis_Homo sapiens_hsa051402.62875885
8Type I diabetes mellitus_Homo sapiens_hsa049402.61807487
9B cell receptor signaling pathway_Homo sapiens_hsa046622.34164159
10Osteoclast differentiation_Homo sapiens_hsa043802.26032406
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13488275
12Staphylococcus aureus infection_Homo sapiens_hsa051502.06389873
13T cell receptor signaling pathway_Homo sapiens_hsa046602.05814090
14Viral myocarditis_Homo sapiens_hsa054162.00669272
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94168271
16Measles_Homo sapiens_hsa051621.79399402
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.60678964
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.60478199
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58064828
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.57164011
21Hematopoietic cell lineage_Homo sapiens_hsa046401.56980233
22Asthma_Homo sapiens_hsa053101.56908267
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.55692596
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50250921
25Tuberculosis_Homo sapiens_hsa051521.49258975
26Chemokine signaling pathway_Homo sapiens_hsa040621.48139206
27Herpes simplex infection_Homo sapiens_hsa051681.46104407
28TNF signaling pathway_Homo sapiens_hsa046681.41917319
29Toxoplasmosis_Homo sapiens_hsa051451.37060470
30Malaria_Homo sapiens_hsa051441.36854921
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36033890
32Platelet activation_Homo sapiens_hsa046111.26287430
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24003966
34Apoptosis_Homo sapiens_hsa042101.23076669
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19368332
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.17921975
37Hepatitis B_Homo sapiens_hsa051611.10497630
38Influenza A_Homo sapiens_hsa051641.06906221
39Legionellosis_Homo sapiens_hsa051341.04079121
40Acute myeloid leukemia_Homo sapiens_hsa052211.02020128
41Shigellosis_Homo sapiens_hsa051311.00201072
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96209228
43African trypanosomiasis_Homo sapiens_hsa051430.90757624
44Rheumatoid arthritis_Homo sapiens_hsa053230.86471769
45Hepatitis C_Homo sapiens_hsa051600.84433522
46Epstein-Barr virus infection_Homo sapiens_hsa051690.83032975
47Phagosome_Homo sapiens_hsa041450.79456628
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79237634
49Pancreatic cancer_Homo sapiens_hsa052120.78014684
50Pertussis_Homo sapiens_hsa051330.77318884
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75733285
52Non-small cell lung cancer_Homo sapiens_hsa052230.66105826
53Inositol phosphate metabolism_Homo sapiens_hsa005620.65982137
54VEGF signaling pathway_Homo sapiens_hsa043700.65835765
55Viral carcinogenesis_Homo sapiens_hsa052030.65399524
56HTLV-I infection_Homo sapiens_hsa051660.63669206
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58819830
58Endocytosis_Homo sapiens_hsa041440.55342905
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54924243
60Chronic myeloid leukemia_Homo sapiens_hsa052200.54310657
61Regulation of autophagy_Homo sapiens_hsa041400.53803788
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52181708
63Dorso-ventral axis formation_Homo sapiens_hsa043200.50823916
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.49817641
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.47926561
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.47868531
67Prolactin signaling pathway_Homo sapiens_hsa049170.47412945
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45494824
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44655064
70Ether lipid metabolism_Homo sapiens_hsa005650.44337994
71mTOR signaling pathway_Homo sapiens_hsa041500.44082184
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43807058
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43689637
74Choline metabolism in cancer_Homo sapiens_hsa052310.43199508
75Salmonella infection_Homo sapiens_hsa051320.42955206
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.42546175
77Insulin resistance_Homo sapiens_hsa049310.38685945
78Linoleic acid metabolism_Homo sapiens_hsa005910.37904078
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34780230
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.34504417
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.34370543
82MAPK signaling pathway_Homo sapiens_hsa040100.34162801
83Nitrogen metabolism_Homo sapiens_hsa009100.33454647
84Lysosome_Homo sapiens_hsa041420.32162329
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31475516
86Oxytocin signaling pathway_Homo sapiens_hsa049210.28768642
87FoxO signaling pathway_Homo sapiens_hsa040680.26486970
88Colorectal cancer_Homo sapiens_hsa052100.23354255
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23101127
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22264261
91Glycerolipid metabolism_Homo sapiens_hsa005610.22086285
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.21517933
93Prostate cancer_Homo sapiens_hsa052150.20931393
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20783517
95Renal cell carcinoma_Homo sapiens_hsa052110.20410584
96Ras signaling pathway_Homo sapiens_hsa040140.20289175
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19373357
98GnRH signaling pathway_Homo sapiens_hsa049120.18493768
99Type II diabetes mellitus_Homo sapiens_hsa049300.18321146
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17749433

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