KLRF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.80458813
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.80458813
3cellular response to interleukin-15 (GO:0071350)6.30368011
4sleep (GO:0030431)6.05625959
5adenosine metabolic process (GO:0046085)5.58016428
6regulation of memory T cell differentiation (GO:0043380)5.32563143
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.24840838
8response to interleukin-15 (GO:0070672)4.94122281
9mast cell activation (GO:0045576)4.57927441
10regulation of T cell mediated cytotoxicity (GO:0001914)4.42696118
11cellular response to prostaglandin stimulus (GO:0071379)4.33591543
12mast cell activation involved in immune response (GO:0002279)4.22726601
13mast cell degranulation (GO:0043303)4.22726601
14chaperone mediated protein folding requiring cofactor (GO:0051085)4.15564281
15regulation of leukocyte mediated cytotoxicity (GO:0001910)4.10038244
16positive regulation of T cell mediated cytotoxicity (GO:0001916)3.91404575
17phosphate ion homeostasis (GO:0055062)3.85577553
18trivalent inorganic anion homeostasis (GO:0072506)3.85577553
19positive regulation of T cell cytokine production (GO:0002726)3.78898546
20regulation of germinal center formation (GO:0002634)3.78713590
21negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.73515759
22regulation of cell killing (GO:0031341)3.72643331
23negative regulation of T cell mediated immunity (GO:0002710)3.68633919
24tolerance induction (GO:0002507)3.68106650
25positive regulation of defense response to virus by host (GO:0002230)3.67833030
26positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.67265054
27response to pheromone (GO:0019236)3.63342311
28negative regulation of T-helper cell differentiation (GO:0045623)3.53269749
29negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.53269749
30growth hormone receptor signaling pathway (GO:0060396)3.51845827
31histone H2A monoubiquitination (GO:0035518)3.51289189
32negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.50978975
33preassembly of GPI anchor in ER membrane (GO:0016254)3.49564051
34regulation of T-helper 1 type immune response (GO:0002825)3.49096278
35positive regulation of interleukin-8 secretion (GO:2000484)3.47232125
36lymph node development (GO:0048535)3.46221665
37regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43738679
38regulation of mitotic spindle checkpoint (GO:1903504)3.43738679
39male sex determination (GO:0030238)3.43188723
40multicellular organism reproduction (GO:0032504)3.40674777
41regulation of monocyte differentiation (GO:0045655)3.37225717
42negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.34804887
43regulation of natural killer cell mediated immunity (GO:0002715)3.34798216
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.34798216
45positive regulation of T-helper 1 type immune response (GO:0002827)3.34284755
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33917893
47production of molecular mediator of immune response (GO:0002440)3.31454157
48positive regulation of osteoclast differentiation (GO:0045672)3.29685521
49positive regulation of alpha-beta T cell proliferation (GO:0046641)3.29490041
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.27868550
51positive regulation of cell killing (GO:0031343)3.26582247
52positive regulation of T cell differentiation in thymus (GO:0033089)3.26418548
53tumor necrosis factor-mediated signaling pathway (GO:0033209)3.24290156
54histone H2A ubiquitination (GO:0033522)3.23994018
55positive thymic T cell selection (GO:0045059)3.23008819
56cellular response to growth hormone stimulus (GO:0071378)3.17867729
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.16591801
58regulation of immunoglobulin secretion (GO:0051023)3.15203534
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.14073290
60regulation of B cell receptor signaling pathway (GO:0050855)3.12212256
61maturation of 5.8S rRNA (GO:0000460)3.07983332
62negative regulation of telomere maintenance (GO:0032205)3.07068982
63regulation of alpha-beta T cell proliferation (GO:0046640)3.05429354
64positive regulation of T cell mediated immunity (GO:0002711)3.03731992
65cellular defense response (GO:0006968)3.03214842
66negative T cell selection (GO:0043383)3.01552757
67negative thymic T cell selection (GO:0045060)3.01483560
68lysosome localization (GO:0032418)3.00173428
69positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.98846898
70regulation of T cell mediated immunity (GO:0002709)2.97994488
71negative regulation of JAK-STAT cascade (GO:0046426)2.97506091
72positive regulation of prostaglandin secretion (GO:0032308)2.96342374
73interleukin-6-mediated signaling pathway (GO:0070102)2.94792046
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.90509770
75negative regulation of B cell apoptotic process (GO:0002903)2.90494029
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.85437784
77negative regulation of alpha-beta T cell differentiation (GO:0046639)2.84601266
78positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.83864745
79regulation of T-helper 1 cell differentiation (GO:0045625)2.81332508
80antigen processing and presentation of endogenous antigen (GO:0019883)2.79846667
81regulation of interleukin-8 secretion (GO:2000482)2.79242956
82ubiquinone biosynthetic process (GO:0006744)2.77681138
83regulation of regulatory T cell differentiation (GO:0045589)2.76757734
84regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.75046089
85negative regulation of innate immune response (GO:0045824)2.72771180
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.69329713
87positive regulation of T-helper cell differentiation (GO:0045624)2.66548098
88regulation of vacuole organization (GO:0044088)2.65042279
89regulation of antigen processing and presentation (GO:0002577)2.63474623
90cellular response to exogenous dsRNA (GO:0071360)2.61944980
91response to interferon-beta (GO:0035456)2.61864472
92negative regulation of protein autophosphorylation (GO:0031953)2.61519090
93immunoglobulin mediated immune response (GO:0016064)2.61165193
94response to muramyl dipeptide (GO:0032495)2.60766783
95positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.57436620
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57244967
97phosphatidylserine acyl-chain remodeling (GO:0036150)2.55651789
98regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55223113
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.53896611
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53799226

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.76274303
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.34768772
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.32061622
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30417785
5RUNX_20019798_ChIP-Seq_JUKART_Human3.62478622
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67989235
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.47063861
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.37214901
9MYB_26560356_Chip-Seq_TH2_Human2.34956033
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30525909
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.24040425
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16216556
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12859915
14IRF1_19129219_ChIP-ChIP_H3396_Human2.10766239
15GATA3_26560356_Chip-Seq_TH2_Human2.06856811
16CIITA_25753668_ChIP-Seq_RAJI_Human1.95718063
17GATA3_27048872_Chip-Seq_THYMUS_Human1.93454559
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93116923
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87048527
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.81050999
21VDR_23849224_ChIP-Seq_CD4+_Human1.75634046
22STAT1_20625510_ChIP-Seq_HELA_Human1.72953843
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69420557
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68340791
25MYB_26560356_Chip-Seq_TH1_Human1.59785682
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58488379
27ZNF274_21170338_ChIP-Seq_K562_Hela1.57629615
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55812790
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.51811978
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46563304
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.45948042
32GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44625289
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40728878
34UTX_26944678_Chip-Seq_JUKART_Human1.40247057
35IGF1R_20145208_ChIP-Seq_DFB_Human1.38901244
36AR_20517297_ChIP-Seq_VCAP_Human1.38597788
37TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.37923905
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36466455
39FOXP3_21729870_ChIP-Seq_TREG_Human1.35851554
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33417952
41SPI1_23547873_ChIP-Seq_NB4_Human1.31547003
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31403206
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30075740
44EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29628927
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27568417
46GATA1_22025678_ChIP-Seq_K562_Human1.23462255
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23257597
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21487311
49ER_23166858_ChIP-Seq_MCF-7_Human1.20449236
50RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.17582732
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14254190
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.14183055
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.14064699
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13425065
55FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12740356
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11320987
57TP53_22573176_ChIP-Seq_HFKS_Human1.08976532
58FOXH1_21741376_ChIP-Seq_EPCs_Human1.08776695
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08606611
60GATA3_26560356_Chip-Seq_TH1_Human1.08197026
61HOXB7_26014856_ChIP-Seq_BT474_Human1.07839960
62GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07815264
63FOXA1_25329375_ChIP-Seq_VCAP_Human1.07724185
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07724185
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07675663
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06921372
67MYC_18940864_ChIP-ChIP_HL60_Human1.06880487
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.06805468
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06287377
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05962169
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03295458
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03085609
73MAF_26560356_Chip-Seq_TH2_Human1.01135805
74MAF_26560356_Chip-Seq_TH1_Human0.99587156
75GABP_17652178_ChIP-ChIP_JURKAT_Human0.98960570
76BCL6_27268052_Chip-Seq_Bcells_Human0.98848599
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98264045
78NANOG_20526341_ChIP-Seq_ESCs_Human0.97895912
79VDR_24787735_ChIP-Seq_THP-1_Human0.96908519
80EZH2_22144423_ChIP-Seq_EOC_Human0.96741962
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.96697839
82GBX2_23144817_ChIP-Seq_PC3_Human0.96435117
83PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95428047
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94002104
85EST1_17652178_ChIP-ChIP_JURKAT_Human0.93068551
86SCL_19346495_ChIP-Seq_HPC-7_Human0.92958048
87SMRT_27268052_Chip-Seq_Bcells_Human0.92849010
88TAF2_19829295_ChIP-Seq_ESCs_Human0.91881268
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91645485
90CBP_20019798_ChIP-Seq_JUKART_Human0.89373861
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89373861
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89142656
93P300_27268052_Chip-Seq_Bcells_Human0.89080637
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88480102
95TAF15_26573619_Chip-Seq_HEK293_Human0.87911953
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86175674
97EZH2_27294783_Chip-Seq_NPCs_Mouse0.86167814
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.85929903
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84036888
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83368469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.89046255
2MP0005671_abnormal_response_to4.43140808
3MP0001835_abnormal_antigen_presentation3.98947556
4MP0003878_abnormal_ear_physiology3.40844884
5MP0005377_hearing/vestibular/ear_phenot3.40844884
6MP0004147_increased_porphyrin_level2.87591588
7MP0003763_abnormal_thymus_physiology2.69962575
8MP0001968_abnormal_touch/_nociception2.61574901
9MP0009785_altered_susceptibility_to2.42804689
10MP0002102_abnormal_ear_morphology2.38058790
11MP0005075_abnormal_melanosome_morpholog2.36911407
12MP0005000_abnormal_immune_tolerance2.31883687
13MP0003724_increased_susceptibility_to2.30940305
14MP0000685_abnormal_immune_system2.26801841
15MP0008875_abnormal_xenobiotic_pharmacok2.12851754
16MP0001800_abnormal_humoral_immune2.01859318
17MP0002148_abnormal_hypersensitivity_rea2.01730932
18MP0002723_abnormal_immune_serum1.99748226
19MP0001819_abnormal_immune_cell1.99658420
20MP0002420_abnormal_adaptive_immunity1.93540392
21MP0002452_abnormal_antigen_presenting1.83536590
22MP0001853_heart_inflammation1.81653750
23MP0004947_skin_inflammation1.78770751
24MP0004043_abnormal_pH_regulation1.76323605
25MP0008877_abnormal_DNA_methylation1.71086860
26MP0002736_abnormal_nociception_after1.71078711
27MP0003436_decreased_susceptibility_to1.69966941
28MP0000716_abnormal_immune_system1.65498524
29MP0004885_abnormal_endolymph1.64158695
30MP0002398_abnormal_bone_marrow1.62848884
31MP0003879_abnormal_hair_cell1.60418608
32MP0000703_abnormal_thymus_morphology1.56022549
33MP0002876_abnormal_thyroid_physiology1.55285328
34MP0008872_abnormal_physiological_respon1.54530346
35MP0002419_abnormal_innate_immunity1.51061932
36MP0002722_abnormal_immune_system1.50791467
37MP0002405_respiratory_system_inflammati1.44640582
38MP0002933_joint_inflammation1.44264938
39MP0009278_abnormal_bone_marrow1.42968368
40MP0005025_abnormal_response_to1.42723255
41MP0005167_abnormal_blood-brain_barrier1.42567346
42MP0000569_abnormal_digit_pigmentation1.42462802
43MP0009764_decreased_sensitivity_to1.42204233
44MP0004084_abnormal_cardiac_muscle1.41989205
45MP0000689_abnormal_spleen_morphology1.40992180
46MP0005174_abnormal_tail_pigmentation1.38693812
47MP0001533_abnormal_skeleton_physiology1.38110680
48MP0002638_abnormal_pupillary_reflex1.35103510
49MP0006072_abnormal_retinal_apoptosis1.32287836
50MP0003786_premature_aging1.31171300
51MP0002429_abnormal_blood_cell1.28903935
52MP0008775_abnormal_heart_ventricle1.27398041
53MP0001986_abnormal_taste_sensitivity1.26146128
54MP0003195_calcinosis1.22165052
55MP0000465_gastrointestinal_hemorrhage1.21729776
56MP0002166_altered_tumor_susceptibility1.18990757
57MP0005387_immune_system_phenotype1.18119946
58MP0001790_abnormal_immune_system1.18119946
59MP0002998_abnormal_bone_remodeling1.17387226
60MP0001501_abnormal_sleep_pattern1.12092852
61MP0009333_abnormal_splenocyte_physiolog1.11065935
62MP0003638_abnormal_response/metabolism_1.09876316
63MP0003252_abnormal_bile_duct1.08556151
64MP0010155_abnormal_intestine_physiology1.07441302
65MP0000427_abnormal_hair_cycle1.05689865
66MP0002837_dystrophic_cardiac_calcinosis1.03741964
67MP0001485_abnormal_pinna_reflex1.01285380
68MP0001765_abnormal_ion_homeostasis1.00134382
69MP0001845_abnormal_inflammatory_respons0.97496856
70MP0003011_delayed_dark_adaptation0.89485112
71MP0003866_abnormal_defecation0.87214433
72MP0001529_abnormal_vocalization0.83917851
73MP0005645_abnormal_hypothalamus_physiol0.83473372
74MP0002006_tumorigenesis0.83175897
75MP0005551_abnormal_eye_electrophysiolog0.82455521
76MP0002653_abnormal_ependyma_morphology0.82340115
77MP0008469_abnormal_protein_level0.80890512
78MP0005083_abnormal_biliary_tract0.78858827
79MP0002095_abnormal_skin_pigmentation0.78355745
80MP0001727_abnormal_embryo_implantation0.78150471
81MP0005253_abnormal_eye_physiology0.77802504
82MP0003183_abnormal_peptide_metabolism0.77405408
83MP0005464_abnormal_platelet_physiology0.69571468
84MP0004145_abnormal_muscle_electrophysio0.67140151
85MP0005390_skeleton_phenotype0.66802423
86MP0001243_abnormal_dermal_layer0.64567741
87MP0010329_abnormal_lipoprotein_level0.63875157
88MP0001984_abnormal_olfaction0.63478195
89MP0001919_abnormal_reproductive_system0.63389542
90MP0000613_abnormal_salivary_gland0.63367564
91MP0004036_abnormal_muscle_relaxation0.63116741
92MP0003795_abnormal_bone_structure0.62989599
93MP0002272_abnormal_nervous_system0.60738049
94MP0002127_abnormal_cardiovascular_syste0.60534002
95MP0008995_early_reproductive_senescence0.59975976
96MP0003656_abnormal_erythrocyte_physiolo0.59121267
97MP0001188_hyperpigmentation0.58406065
98MP0002877_abnormal_melanocyte_morpholog0.58343028
99MP0001851_eye_inflammation0.57030373
100MP0004924_abnormal_behavior0.56524189

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)5.41031141
2Severe combined immunodeficiency (HP:0004430)5.21755448
3T lymphocytopenia (HP:0005403)4.98439392
4Dry hair (HP:0011359)4.67048729
5Abnormality of eosinophils (HP:0001879)4.65423289
6Thyroiditis (HP:0100646)4.53855000
7Abnormality of T cell number (HP:0011839)4.52882808
8Abnormality of the axillary hair (HP:0100134)4.52681087
9Abnormality of secondary sexual hair (HP:0009888)4.52681087
10Abnormality of B cell number (HP:0010975)4.34745343
11Fair hair (HP:0002286)4.29461258
12IgG deficiency (HP:0004315)4.16913905
13B lymphocytopenia (HP:0010976)4.02456286
14Combined immunodeficiency (HP:0005387)3.99287762
15Elevated erythrocyte sedimentation rate (HP:0003565)3.96811222
16Prostate neoplasm (HP:0100787)3.92940408
17Hypotrichosis (HP:0001006)3.89217094
18Congenital stationary night blindness (HP:0007642)3.84436851
19Renal cortical cysts (HP:0000803)3.83439320
20Eosinophilia (HP:0001880)3.60613014
21Generalized hypopigmentation of hair (HP:0011358)3.49148288
22Abnormality of hair growth rate (HP:0011363)3.45781427
23Slow-growing hair (HP:0002217)3.45781427
24Stomach cancer (HP:0012126)3.22550413
25Type II lissencephaly (HP:0007260)3.22478402
26Abnormality of T cells (HP:0002843)3.21245318
27Brittle hair (HP:0002299)3.16628730
28Abnormality of the prostate (HP:0008775)3.15959361
29Granulocytopenia (HP:0001913)3.04605993
30Ridged nail (HP:0001807)2.95252842
31Potter facies (HP:0002009)2.94220364
32Facial shape deformation (HP:0011334)2.94220364
33Retrobulbar optic neuritis (HP:0100654)2.93809285
34Optic neuritis (HP:0100653)2.93809285
35Leukocytosis (HP:0001974)2.87111210
36Amelogenesis imperfecta (HP:0000705)2.85325582
37Conical tooth (HP:0000698)2.76940899
38Panhypogammaglobulinemia (HP:0003139)2.73880705
39Myositis (HP:0100614)2.72272085
40Progressive microcephaly (HP:0000253)2.63192429
41Abnormality of dental color (HP:0011073)2.60355277
42Delayed CNS myelination (HP:0002188)2.51272162
43Abnormality of the renal cortex (HP:0011035)2.49343057
44Pancreatic cysts (HP:0001737)2.48742943
453-Methylglutaconic aciduria (HP:0003535)2.48307306
46Abnormality of the pons (HP:0007361)2.39180107
47Orchitis (HP:0100796)2.38849423
48Sparse scalp hair (HP:0002209)2.37340377
49Abolished electroretinogram (ERG) (HP:0000550)2.28367951
50Vasculitis (HP:0002633)2.26675942
51Recurrent bronchitis (HP:0002837)2.26069684
52Adactyly (HP:0009776)2.25668994
53Abnormal rod and cone electroretinograms (HP:0008323)2.23426695
54Pustule (HP:0200039)2.22909726
55Woolly hair (HP:0002224)2.19861405
56Hypoplasia of the pons (HP:0012110)2.18797204
57Pulmonary fibrosis (HP:0002206)2.15915780
58Anhidrosis (HP:0000970)2.15245825
59Pruritus (HP:0000989)2.14612909
60Cerebellar dysplasia (HP:0007033)2.13860761
61Hypoplasia of the thymus (HP:0000778)2.12016782
62Pulmonary infiltrates (HP:0002113)2.09765246
63Stomatitis (HP:0010280)2.08359344
64Agammaglobulinemia (HP:0004432)2.06076780
65Keratoconjunctivitis (HP:0001096)2.00182373
66Tongue fasciculations (HP:0001308)1.99733995
67Clumsiness (HP:0002312)1.94320569
68Non-midline cleft lip (HP:0100335)1.93510229
69Recurrent fungal infections (HP:0002841)1.92363960
70Abnormality of T cell physiology (HP:0011840)1.92350418
71IgM deficiency (HP:0002850)1.91950777
72Nephronophthisis (HP:0000090)1.90382383
73Keratoconjunctivitis sicca (HP:0001097)1.88841755
74Ulnar claw (HP:0001178)1.87002320
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86270750
76Abnormal protein N-linked glycosylation (HP:0012347)1.86270750
77Abnormal protein glycosylation (HP:0012346)1.86270750
78Abnormal glycosylation (HP:0012345)1.86270750
79Molar tooth sign on MRI (HP:0002419)1.84531192
80Abnormality of midbrain morphology (HP:0002418)1.84531192
81Abnormality of male internal genitalia (HP:0000022)1.84088654
82Abnormality of the pupil (HP:0000615)1.82361573
83Gastrointestinal stroma tumor (HP:0100723)1.80574764
84Muscle fibrillation (HP:0010546)1.80192861
85Sparse eyelashes (HP:0000653)1.79173556
86Chronic mucocutaneous candidiasis (HP:0002728)1.77661790
87Recurrent cutaneous fungal infections (HP:0011370)1.77661790
88Persistence of primary teeth (HP:0006335)1.77073786
89Abnormal biliary tract physiology (HP:0012439)1.76870808
90Bile duct proliferation (HP:0001408)1.76870808
91Short tibia (HP:0005736)1.76472498
92True hermaphroditism (HP:0010459)1.75064294
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.74620567
94Abnormality of glycolipid metabolism (HP:0010969)1.72926172
95Abnormality of liposaccharide metabolism (HP:0010968)1.72926172
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.72926172
97Porencephaly (HP:0002132)1.72611506
98Joint swelling (HP:0001386)1.71464078
99Hypoproteinemia (HP:0003075)1.69765741
100Retinal dysplasia (HP:0007973)1.68300457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.34468083
2TAOK35.32298866
3TXK5.05769701
4TLK13.96180743
5MAP3K143.41990787
6STK163.37235865
7GRK63.03993636
8ZAK2.86031533
9BMPR1B2.65770647
10KIT2.47818438
11MAP4K12.23768107
12RIPK41.96003701
13BRD41.80846741
14FRK1.75801818
15JAK11.57379247
16TBK11.46328083
17MET1.45582912
18BMPR21.44744369
19EPHA31.42638739
20OXSR11.39747418
21FES1.39684220
22BCKDK1.33353298
23CLK11.31490288
24NUAK11.30726682
25ADRBK21.29137005
26IKBKB1.25823400
27IKBKE1.25217480
28GRK11.21538633
29SYK1.20859162
30MAPKAPK31.18503580
31STK391.13786247
32WNK41.13004099
33CDK191.07569224
34EIF2AK21.06372855
35EEF2K1.03280057
36MAP2K20.95324336
37EIF2AK10.94977142
38LCK0.92300236
39ITK0.91177560
40CSF1R0.87179767
41HCK0.86510815
42TEC0.81627872
43MATK0.80137342
44PRKCQ0.79811987
45VRK10.78141930
46JAK30.75897616
47LYN0.75168911
48IGF1R0.75133097
49KDR0.74517436
50PRKD20.72938366
51MST40.71804918
52PHKG10.70166484
53PHKG20.70166484
54PLK20.69460754
55TESK20.65784229
56CHUK0.65125201
57TGFBR10.64820294
58MARK30.63770944
59MAPKAPK20.60485312
60IRAK10.58313388
61MAPKAPK50.57569561
62MAP3K130.54151622
63PINK10.52859710
64ZAP700.52227059
65IRAK40.47323277
66TRPM70.45609164
67ERBB30.44926045
68BTK0.44797618
69MAPK110.42801384
70CSNK1G30.41127310
71PRKCI0.40865061
72CDK30.40852183
73CSNK1A1L0.40044400
74CDK80.39506659
75INSR0.39317499
76STK40.38952196
77MAPK130.37164957
78ABL10.36918251
79PKN10.35339493
80RPS6KB20.34631098
81FLT30.34162934
82PIM10.33545377
83CSK0.32492099
84NME10.32388626
85PIK3CA0.31778243
86NEK60.31675441
87CSNK1D0.31048525
88CSNK1G20.29436567
89TYK20.29114864
90FYN0.28550036
91RPS6KA50.25894169
92PRKCE0.25016777
93MAP3K70.24694871
94INSRR0.24074951
95MAPK70.23329593
96STK380.23015547
97EIF2AK30.22460111
98ADRBK10.21569357
99EGFR0.18650065
100CHEK20.17432590

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046723.80711759
2Primary immunodeficiency_Homo sapiens_hsa053403.72745492
3Asthma_Homo sapiens_hsa053103.57133551
4Graft-versus-host disease_Homo sapiens_hsa053323.49927469
5Caffeine metabolism_Homo sapiens_hsa002323.27713577
6Allograft rejection_Homo sapiens_hsa053302.91450226
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78131343
8Autoimmune thyroid disease_Homo sapiens_hsa053202.73431007
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.71963363
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53495519
11Antigen processing and presentation_Homo sapiens_hsa046122.50414718
12Type I diabetes mellitus_Homo sapiens_hsa049402.19760362
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16191694
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.10523442
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09787311
16Linoleic acid metabolism_Homo sapiens_hsa005911.98715142
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91712096
18Phototransduction_Homo sapiens_hsa047441.86182011
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84567909
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78102233
21Nitrogen metabolism_Homo sapiens_hsa009101.77142079
22Rheumatoid arthritis_Homo sapiens_hsa053231.60699730
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.59027155
24Leishmaniasis_Homo sapiens_hsa051401.53699800
25Hematopoietic cell lineage_Homo sapiens_hsa046401.53695155
26Viral myocarditis_Homo sapiens_hsa054161.47947564
27Sulfur metabolism_Homo sapiens_hsa009201.47111780
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35647719
29Staphylococcus aureus infection_Homo sapiens_hsa051501.27409500
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26573794
31Herpes simplex infection_Homo sapiens_hsa051681.25729190
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24989299
33Tryptophan metabolism_Homo sapiens_hsa003801.24093432
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23339537
35Arachidonic acid metabolism_Homo sapiens_hsa005901.23037683
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.18746373
37Ether lipid metabolism_Homo sapiens_hsa005651.12269605
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11814512
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10800375
40T cell receptor signaling pathway_Homo sapiens_hsa046601.10665537
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00643078
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97740639
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88478060
44Base excision repair_Homo sapiens_hsa034100.87848295
45Proteasome_Homo sapiens_hsa030500.79172658
46ABC transporters_Homo sapiens_hsa020100.77733576
47RNA degradation_Homo sapiens_hsa030180.75336627
48Toxoplasmosis_Homo sapiens_hsa051450.74896738
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73264785
50Peroxisome_Homo sapiens_hsa041460.66335525
51Homologous recombination_Homo sapiens_hsa034400.65236205
52B cell receptor signaling pathway_Homo sapiens_hsa046620.59857945
53Malaria_Homo sapiens_hsa051440.59379499
54Chemical carcinogenesis_Homo sapiens_hsa052040.55243377
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53068293
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.52405373
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50054560
58Measles_Homo sapiens_hsa051620.48766828
59Osteoclast differentiation_Homo sapiens_hsa043800.47678522
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45047092
61RNA polymerase_Homo sapiens_hsa030200.44877349
62Tuberculosis_Homo sapiens_hsa051520.42672007
63Retinol metabolism_Homo sapiens_hsa008300.42113768
64Non-homologous end-joining_Homo sapiens_hsa034500.40668380
65Lysosome_Homo sapiens_hsa041420.40253054
66Legionellosis_Homo sapiens_hsa051340.39788554
67TNF signaling pathway_Homo sapiens_hsa046680.38638771
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.38385322
69Morphine addiction_Homo sapiens_hsa050320.37907140
70Systemic lupus erythematosus_Homo sapiens_hsa053220.34900416
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34500504
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.33945023
73Ovarian steroidogenesis_Homo sapiens_hsa049130.33756846
74Olfactory transduction_Homo sapiens_hsa047400.32645001
75Sulfur relay system_Homo sapiens_hsa041220.32621889
76Fanconi anemia pathway_Homo sapiens_hsa034600.31987396
77Influenza A_Homo sapiens_hsa051640.31469032
78African trypanosomiasis_Homo sapiens_hsa051430.31302014
79Basal transcription factors_Homo sapiens_hsa030220.31254201
80Propanoate metabolism_Homo sapiens_hsa006400.30640984
81Selenocompound metabolism_Homo sapiens_hsa004500.28492706
82Viral carcinogenesis_Homo sapiens_hsa052030.27988996
83Other glycan degradation_Homo sapiens_hsa005110.27164520
84Epstein-Barr virus infection_Homo sapiens_hsa051690.26896202
85Fatty acid elongation_Homo sapiens_hsa000620.26863074
86Salivary secretion_Homo sapiens_hsa049700.26840283
87Phenylalanine metabolism_Homo sapiens_hsa003600.26664310
88Taste transduction_Homo sapiens_hsa047420.24832843
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.23671567
90Purine metabolism_Homo sapiens_hsa002300.23449001
91Sphingolipid metabolism_Homo sapiens_hsa006000.23437372
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.23148018
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22161569
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21084882
95Acute myeloid leukemia_Homo sapiens_hsa052210.20077380
96Serotonergic synapse_Homo sapiens_hsa047260.19986007
97Fat digestion and absorption_Homo sapiens_hsa049750.19701077
98Renin-angiotensin system_Homo sapiens_hsa046140.19195312
99Butanoate metabolism_Homo sapiens_hsa006500.17386861
100One carbon pool by folate_Homo sapiens_hsa006700.15128070

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