KLRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)9.34029119
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)9.34029119
3negative T cell selection (GO:0043383)8.31920245
4positive regulation of gamma-delta T cell activation (GO:0046645)8.10572794
5regulation of isotype switching to IgG isotypes (GO:0048302)8.00667080
6T cell migration (GO:0072678)7.93112027
7negative thymic T cell selection (GO:0045060)7.85443009
8positive thymic T cell selection (GO:0045059)7.00168360
9interferon-gamma production (GO:0032609)6.90327471
10positive T cell selection (GO:0043368)6.80835195
11cellular response to interleukin-15 (GO:0071350)6.40029799
12thymic T cell selection (GO:0045061)6.39040725
13regulation of gamma-delta T cell differentiation (GO:0045586)6.27377266
14regulation of natural killer cell mediated immunity (GO:0002715)6.18906001
15regulation of natural killer cell mediated cytotoxicity (GO:0042269)6.18906001
16response to interleukin-15 (GO:0070672)6.10475992
17activated T cell proliferation (GO:0050798)5.93015888
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.81430718
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.81430718
20T cell selection (GO:0045058)5.76381060
21positive regulation of natural killer cell mediated immunity (GO:0002717)5.73411953
22positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.73411953
23regulation of gamma-delta T cell activation (GO:0046643)5.64184545
24heterotypic cell-cell adhesion (GO:0034113)5.59515889
25positive regulation of immunoglobulin production (GO:0002639)5.51657198
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.37897649
27DNA deamination (GO:0045006)5.22413764
28leukocyte aggregation (GO:0070486)5.16813831
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.03283279
30positive regulation of T cell mediated cytotoxicity (GO:0001916)5.02767087
31negative regulation of T cell mediated immunity (GO:0002710)5.01089258
32positive regulation of isotype switching (GO:0045830)4.99063677
33cytidine metabolic process (GO:0046087)4.89531773
34cytidine catabolic process (GO:0006216)4.89531773
35cytidine deamination (GO:0009972)4.89531773
36antigen processing and presentation of endogenous antigen (GO:0019883)4.84567603
37regulation of B cell receptor signaling pathway (GO:0050855)4.82146949
38regulation of chronic inflammatory response (GO:0002676)4.81584700
39lymphocyte migration (GO:0072676)4.79864693
40regulation of regulatory T cell differentiation (GO:0045589)4.77096141
41lymphocyte costimulation (GO:0031294)4.73438702
42T cell costimulation (GO:0031295)4.73392362
43T cell receptor signaling pathway (GO:0050852)4.69575836
44regulation of T cell tolerance induction (GO:0002664)4.69544965
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.69054083
46regulation of immunoglobulin production (GO:0002637)4.67752527
47regulation of leukocyte mediated cytotoxicity (GO:0001910)4.62936159
48regulation of T cell mediated cytotoxicity (GO:0001914)4.62836934
49cytolysis (GO:0019835)4.61345581
50leukocyte cell-cell adhesion (GO:0007159)4.60181421
51regulation of isotype switching (GO:0045191)4.55102560
52tolerance induction (GO:0002507)4.54951466
53positive regulation of DNA recombination (GO:0045911)4.44554074
54sequestering of actin monomers (GO:0042989)4.41173398
55positive regulation of T cell cytokine production (GO:0002726)4.37202099
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.32718364
57pyrimidine ribonucleoside catabolic process (GO:0046133)4.31774073
58positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.31737965
59positive regulation of B cell mediated immunity (GO:0002714)4.29787487
60positive regulation of immunoglobulin mediated immune response (GO:0002891)4.29787487
61regulation of cell killing (GO:0031341)4.25531838
62positive regulation of granulocyte differentiation (GO:0030854)4.14606652
63positive regulation of alpha-beta T cell proliferation (GO:0046641)4.11823430
64positive regulation of tolerance induction (GO:0002645)4.10142560
65regulation of alpha-beta T cell proliferation (GO:0046640)4.09798057
66mast cell activation (GO:0045576)4.02934173
67regulation of immunoglobulin mediated immune response (GO:0002889)3.98612429
68positive regulation of cell killing (GO:0031343)3.95903440
69antigen receptor-mediated signaling pathway (GO:0050851)3.94754198
70natural killer cell activation (GO:0030101)3.92514749
71positive regulation of immune response to tumor cell (GO:0002839)3.89474839
72regulation of immune response to tumor cell (GO:0002837)3.89474839
73regulation of response to tumor cell (GO:0002834)3.89474839
74positive regulation of response to tumor cell (GO:0002836)3.89474839
75* cellular defense response (GO:0006968)3.88594219
76leukocyte tethering or rolling (GO:0050901)3.87905768
77T-helper cell differentiation (GO:0042093)3.86646664
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.86646664
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85668623
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.84641361
81regulation of B cell mediated immunity (GO:0002712)3.83588624
82negative regulation of lymphocyte mediated immunity (GO:0002707)3.77932965
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.74151255
84alpha-beta T cell differentiation involved in immune response (GO:0002293)3.72053355
85alpha-beta T cell activation involved in immune response (GO:0002287)3.72053355
86T cell differentiation involved in immune response (GO:0002292)3.72053355
87actin nucleation (GO:0045010)3.68296990
88positive regulation of T cell chemotaxis (GO:0010820)3.66175400
89regulation of T cell chemotaxis (GO:0010819)3.66175400
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.63844575
91positive regulation of T cell mediated immunity (GO:0002711)3.63807586
92regulation of tolerance induction (GO:0002643)3.57807963
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53489629
94positive regulation of humoral immune response (GO:0002922)3.51666041
95positive regulation of B cell proliferation (GO:0030890)3.51254525
96regulation of lymphocyte mediated immunity (GO:0002706)3.51235067
97negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.50769972
98T cell differentiation (GO:0030217)3.45595533
99regulation of B cell differentiation (GO:0045577)3.44471539
100regulation of B cell proliferation (GO:0030888)3.43033558
101T cell proliferation (GO:0042098)3.41311952
102regulation of chemokine-mediated signaling pathway (GO:0070099)3.40325423
103alpha-beta T cell activation (GO:0046631)3.39626770
104T cell activation involved in immune response (GO:0002286)3.39419078
105positive regulation of B cell differentiation (GO:0045579)3.33561549
106positive regulation of lymphocyte mediated immunity (GO:0002708)3.32508156
107regulation of T cell receptor signaling pathway (GO:0050856)3.30217879
108negative regulation of interleukin-12 production (GO:0032695)3.30018914
109alpha-beta T cell differentiation (GO:0046632)3.27664185
110regulation of T cell cytokine production (GO:0002724)3.25182918
111B cell receptor signaling pathway (GO:0050853)3.24770854
112positive regulation of calcium-mediated signaling (GO:0050850)3.24770628
113positive regulation of T-helper 1 type immune response (GO:0002827)3.24723118
114Peyers patch development (GO:0048541)3.24088188
115mucosal-associated lymphoid tissue development (GO:0048537)3.24088188
116Arp2/3 complex-mediated actin nucleation (GO:0034314)3.23068903
117regulation of defense response to virus by virus (GO:0050690)3.22088259
118regulation of activation of Janus kinase activity (GO:0010533)3.21843206
119regulation of T cell mediated immunity (GO:0002709)3.21352573
120negative regulation of T cell apoptotic process (GO:0070233)3.21127492
121lymphocyte chemotaxis (GO:0048247)3.18535335
122mast cell degranulation (GO:0043303)3.15131757
123mast cell activation involved in immune response (GO:0002279)3.15131757
124regulation of lymphocyte chemotaxis (GO:1901623)3.00953103
125positive regulation of defense response to virus by host (GO:0002230)2.96454509
126positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.89571610
127negative regulation of leukocyte mediated immunity (GO:0002704)2.88243791
128T cell mediated immunity (GO:0002456)2.85977887
129positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.82464924
130regulation of interleukin-2 biosynthetic process (GO:0045076)2.81482930
131positive regulation of natural killer cell differentiation (GO:0032825)2.77872609
132regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.77574231
133positive regulation of alpha-beta T cell activation (GO:0046635)2.75176761
134regulation of T-helper 1 type immune response (GO:0002825)2.74930604
135negative regulation of alpha-beta T cell activation (GO:0046636)2.73845141
136NIK/NF-kappaB signaling (GO:0038061)2.73479749
137positive regulation of leukocyte mediated immunity (GO:0002705)2.72530073
138positive regulation of interleukin-4 production (GO:0032753)2.72340599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.93731411
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.48352486
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.89325761
4RUNX_20019798_ChIP-Seq_JUKART_Human4.71646774
5STAT4_19710469_ChIP-ChIP_TH1__Mouse4.38000095
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.86015031
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.82087145
8MYB_26560356_Chip-Seq_TH2_Human3.72015745
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.53141426
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.40149072
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38126593
12MAF_26560356_Chip-Seq_TH1_Human3.25114214
13MYB_26560356_Chip-Seq_TH1_Human2.94823778
14VDR_22108803_ChIP-Seq_LS180_Human2.76947099
15UTX_26944678_Chip-Seq_JUKART_Human2.66806062
16MYC_22102868_ChIP-Seq_BL_Human2.64300975
17ZNF274_21170338_ChIP-Seq_K562_Hela2.60602115
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54896776
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52945270
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.50053919
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.39411361
22GATA3_27048872_Chip-Seq_THYMUS_Human2.29389731
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26176558
24IGF1R_20145208_ChIP-Seq_DFB_Human2.18474416
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17749972
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.15297111
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.11338708
28IRF8_27001747_Chip-Seq_BMDM_Mouse2.07207203
29MAF_26560356_Chip-Seq_TH2_Human2.07001573
30E2F7_22180533_ChIP-Seq_HELA_Human2.04657490
31SPI1_23547873_ChIP-Seq_NB4_Human1.98311490
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.97516869
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.96814954
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88957949
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88538383
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86083138
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82761254
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.82383488
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80941096
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79543718
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79228347
42GATA3_26560356_Chip-Seq_TH2_Human1.73201446
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72136639
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71234318
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68727910
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.66840933
47TCF7_22412390_ChIP-Seq_EML_Mouse1.65244082
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64921742
49VDR_21846776_ChIP-Seq_THP-1_Human1.64825568
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.62796664
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62694598
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60732857
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57423324
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55857157
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54351954
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53105283
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52891535
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51139043
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50549855
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.50152882
61FOXP3_21729870_ChIP-Seq_TREG_Human1.45817690
62KDM2B_26808549_Chip-Seq_DND41_Human1.44770927
63ER_23166858_ChIP-Seq_MCF-7_Human1.38889787
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38522677
65SPI1_23127762_ChIP-Seq_K562_Human1.38321717
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36247769
67VDR_24763502_ChIP-Seq_THP-1_Human1.35201640
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32085625
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30743076
70PU_27001747_Chip-Seq_BMDM_Mouse1.29761499
71TP53_22573176_ChIP-Seq_HFKS_Human1.29491125
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28631882
73* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26005468
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.25605407
75SCL_19346495_ChIP-Seq_HPC-7_Human1.21669672
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21429557
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17227460
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17141985
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16565656
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16339179
81MYC_18940864_ChIP-ChIP_HL60_Human1.14794672
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14604329
83FUS_26573619_Chip-Seq_HEK293_Human1.14195183
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14115842
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.14073735
86IRF1_19129219_ChIP-ChIP_H3396_Human1.13831439
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.12527824
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08483762
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.07673284
90TAF15_26573619_Chip-Seq_HEK293_Human1.07639832
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07117578
92ELK1_19687146_ChIP-ChIP_HELA_Human1.06542892
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05437084
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04843212
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04510279
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03613728
97EWS_26573619_Chip-Seq_HEK293_Human1.02704411
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02505256
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02375693
100AR_20517297_ChIP-Seq_VCAP_Human1.01524168
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00941796
102TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00631519
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99501627
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98603636
105EGR1_19032775_ChIP-ChIP_M12_Human0.98231531
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98152568
107GATA3_21878914_ChIP-Seq_MCF-7_Human0.96541955
108FOXA1_25329375_ChIP-Seq_VCAP_Human0.96529584
109FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96529584
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.96391797
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95697584
112GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95070679
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94931711
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92943522
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.92584543
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.92547461
117NCOR_22424771_ChIP-Seq_293T_Human0.92209806
118VDR_24787735_ChIP-Seq_THP-1_Human0.92053032
119HOXB7_26014856_ChIP-Seq_BT474_Human0.91822787
120P53_22387025_ChIP-Seq_ESCs_Mouse0.91348658
121STAT3_18555785_Chip-Seq_ESCs_Mouse0.89266797
122GATA1_19941826_ChIP-Seq_K562_Human0.88934923
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88887429
124P300_19829295_ChIP-Seq_ESCs_Human0.88657700
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88431991
126CBP_20019798_ChIP-Seq_JUKART_Human0.88424165
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88424165
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87711449
129NMYC_18555785_Chip-Seq_ESCs_Mouse0.87664616
130NANOG_19829295_ChIP-Seq_ESCs_Human0.87635190
131GATA2_19941826_ChIP-Seq_K562_Human0.84314839
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84259437
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81928089
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81063536
135NCOR1_26117541_ChIP-Seq_K562_Human0.79626124
136GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77186858
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77079707
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.76619801
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75654527
140RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75637882
141ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75141012
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75125798
143VDR_23849224_ChIP-Seq_CD4+_Human0.74041028
144PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73048589
145GATA3_26560356_Chip-Seq_TH1_Human0.71228221
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71187912
147FLI1_21867929_ChIP-Seq_CD8_Mouse0.69023382
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.68658780
149HOXB4_20404135_ChIP-ChIP_EML_Mouse0.67101564
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63344898
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62256647
152LXR_22292898_ChIP-Seq_THP-1_Human0.61897580
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.60609232
154FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59871317
155P300_27268052_Chip-Seq_Bcells_Human0.59646364
156SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.59607662
157CIITA_25753668_ChIP-Seq_RAJI_Human0.58310729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.04491973
2MP0003763_abnormal_thymus_physiology4.80564379
3MP0006082_CNS_inflammation4.33762971
4MP0001800_abnormal_humoral_immune3.31186478
5MP0000685_abnormal_immune_system3.30591240
6MP0001835_abnormal_antigen_presentation3.26361558
7MP0005387_immune_system_phenotype3.20938439
8MP0001790_abnormal_immune_system3.20938439
9MP0002420_abnormal_adaptive_immunity3.11107415
10MP0001819_abnormal_immune_cell3.07474011
11MP0009785_altered_susceptibility_to3.01027870
12MP0005000_abnormal_immune_tolerance2.99812087
13MP0002723_abnormal_immune_serum2.92629699
14MP0005025_abnormal_response_to2.88399150
15MP0002398_abnormal_bone_marrow2.79487457
16MP0001873_stomach_inflammation2.77637589
17MP0009333_abnormal_splenocyte_physiolog2.73593917
18MP0002166_altered_tumor_susceptibility2.69309414
19MP0003045_fibrosis2.61998965
20MP0000858_altered_metastatic_potential2.61182368
21MP0002452_abnormal_antigen_presenting2.57055257
22MP0002006_tumorigenesis2.50920893
23MP0003448_altered_tumor_morphology2.48694605
24MP0000716_abnormal_immune_system2.48362128
25MP0000703_abnormal_thymus_morphology2.42065534
26MP0003724_increased_susceptibility_to2.23395746
27MP0002722_abnormal_immune_system2.20099877
28MP0003300_gastrointestinal_ulcer2.18351383
29MP0002405_respiratory_system_inflammati2.14366200
30MP0002148_abnormal_hypersensitivity_rea2.05710021
31MP0002009_preneoplasia2.04744377
32MP0010155_abnormal_intestine_physiology2.00631892
33MP0004947_skin_inflammation2.00605011
34MP0002163_abnormal_gland_morphology1.99612019
35MP0002429_abnormal_blood_cell1.98733516
36MP0003436_decreased_susceptibility_to1.98392640
37MP0002933_joint_inflammation1.92645434
38MP0000689_abnormal_spleen_morphology1.90924377
39MP0005464_abnormal_platelet_physiology1.90064716
40MP0003866_abnormal_defecation1.89626363
41MP0000569_abnormal_digit_pigmentation1.84174245
42MP0002419_abnormal_innate_immunity1.83274245
43MP0001845_abnormal_inflammatory_respons1.78742232
44MP0002132_abnormal_respiratory_system1.62721318
45MP0008877_abnormal_DNA_methylation1.62520556
46MP0001986_abnormal_taste_sensitivity1.59028129
47MP0006072_abnormal_retinal_apoptosis1.56279330
48MP0003646_muscle_fatigue1.55297562
49MP0003303_peritoneal_inflammation1.49368524
50MP0003183_abnormal_peptide_metabolism1.47900360
51MP0005174_abnormal_tail_pigmentation1.47859773
52MP0000372_irregular_coat_pigmentation1.36407427
53MP0005310_abnormal_salivary_gland1.34400877
54MP0002102_abnormal_ear_morphology1.34398841
55MP0002822_catalepsy1.31137597
56MP0002396_abnormal_hematopoietic_system1.30531900
57MP0005645_abnormal_hypothalamus_physiol1.30134613
58MP0005551_abnormal_eye_electrophysiolog1.27692754
59MP0005166_decreased_susceptibility_to1.27260925
60MP0002998_abnormal_bone_remodeling1.24862365
61MP0005379_endocrine/exocrine_gland_phen1.24292706
62MP0008961_abnormal_basal_metabolism1.24149849
63MP0001851_eye_inflammation1.21041821
64MP0008469_abnormal_protein_level1.20197538
65MP0004510_myositis1.15260525
66MP0005253_abnormal_eye_physiology1.13458529
67MP0000465_gastrointestinal_hemorrhage1.10521164
68MP0001533_abnormal_skeleton_physiology1.10501955
69MP0000490_abnormal_crypts_of1.09738399
70MP0005670_abnormal_white_adipose1.09170423
71MP0005083_abnormal_biliary_tract1.08551815
72MP0001853_heart_inflammation1.08434472
73MP0002876_abnormal_thyroid_physiology1.08273065
74MP0000015_abnormal_ear_pigmentation1.05210704
75MP0002019_abnormal_tumor_incidence1.04401787
76MP0009763_increased_sensitivity_to0.96356718
77MP0005646_abnormal_pituitary_gland0.93408175
78MP0002277_abnormal_respiratory_mucosa0.93308965
79MP0006292_abnormal_olfactory_placode0.91619385
80MP0002095_abnormal_skin_pigmentation0.90808662
81MP0004142_abnormal_muscle_tone0.89754722
82MP0005084_abnormal_gallbladder_morpholo0.89722563
83MP0001968_abnormal_touch/_nociception0.89066818
84MP0008057_abnormal_DNA_replication0.86955144
85MP0006054_spinal_hemorrhage0.83530981
86MP0002638_abnormal_pupillary_reflex0.81266411
87MP0002693_abnormal_pancreas_physiology0.80342486
88MP0004808_abnormal_hematopoietic_stem0.79839435
89MP0001501_abnormal_sleep_pattern0.79734911
90MP0004130_abnormal_muscle_cell0.76971291
91MP0008058_abnormal_DNA_repair0.76652571
92MP0004883_abnormal_blood_vessel0.76077936
93MP0002168_other_aberrant_phenotype0.75965093
94MP0002138_abnormal_hepatobiliary_system0.73395651
95MP0001764_abnormal_homeostasis0.72950238
96MP0002736_abnormal_nociception_after0.72392796
97MP0000477_abnormal_intestine_morphology0.69854976
98MP0003252_abnormal_bile_duct0.69478050
99MP0000920_abnormal_myelination0.69320275
100MP0005410_abnormal_fertilization0.68522976
101MP0005085_abnormal_gallbladder_physiolo0.67776090
102MP0008875_abnormal_xenobiotic_pharmacok0.66120284
103MP0003195_calcinosis0.65913757
104MP0005389_reproductive_system_phenotype0.65010209
105MP0009745_abnormal_behavioral_response0.64592643
106MP0003806_abnormal_nucleotide_metabolis0.64378908
107MP0003787_abnormal_imprinting0.64319199
108MP0003795_abnormal_bone_structure0.63983760
109MP0005023_abnormal_wound_healing0.61595165
110MP0006036_abnormal_mitochondrial_physio0.61247057
111MP0003880_abnormal_central_pattern0.61215308
112MP0008873_increased_physiological_sensi0.61006439
113MP0010234_abnormal_vibrissa_follicle0.60470094
114MP0005623_abnormal_meninges_morphology0.60109303
115MP0003172_abnormal_lysosome_physiology0.59606652
116MP0002837_dystrophic_cardiac_calcinosis0.59567594
117MP0004381_abnormal_hair_follicle0.58777454
118MP0003566_abnormal_cell_adhesion0.58007410
119MP0004885_abnormal_endolymph0.57208968
120MP0000249_abnormal_blood_vessel0.54783991
121MP0002136_abnormal_kidney_physiology0.53491478
122MP0005075_abnormal_melanosome_morpholog0.48650009
123MP0010352_gastrointestinal_tract_polyps0.48600430
124MP0003091_abnormal_cell_migration0.48577928
125MP0000609_abnormal_liver_physiology0.48139506
126MP0005584_abnormal_enzyme/coenzyme_acti0.46656258
127MP0005451_abnormal_body_composition0.46346847
128MP0001663_abnormal_digestive_system0.45967762
129MP0000343_altered_response_to0.44304714
130MP0008872_abnormal_physiological_respon0.42027999
131MP0001919_abnormal_reproductive_system0.41838929
132MP0009765_abnormal_xenobiotic_induced0.40447531
133MP0000604_amyloidosis0.39722593
134MP0001243_abnormal_dermal_layer0.38268049
135MP0003453_abnormal_keratinocyte_physiol0.35259629
136MP0005076_abnormal_cell_differentiation0.34552536
137MP0003279_aneurysm0.34521963
138MP0009643_abnormal_urine_homeostasis0.33365894
139MP0001661_extended_life_span0.33094469
140MP0002083_premature_death0.31824147
141MP0010307_abnormal_tumor_latency0.31383883
142MP0005397_hematopoietic_system_phenotyp0.30456278
143MP0001545_abnormal_hematopoietic_system0.30456278
144MP0001191_abnormal_skin_condition0.29845986
145MP0008569_lethality_at_weaning0.29682207
146MP0003329_amyloid_beta_deposits0.29500966
147MP0009764_decreased_sensitivity_to0.29492392
148MP0001765_abnormal_ion_homeostasis0.29439552
149MP0005390_skeleton_phenotype0.28938741

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.57970896
2Abnormality of T cell number (HP:0011839)7.22903967
3Nasal polyposis (HP:0100582)6.01966410
4Optic neuritis (HP:0100653)5.92001654
5Retrobulbar optic neuritis (HP:0100654)5.92001654
6Myositis (HP:0100614)5.88131533
7Abnormality of T cells (HP:0002843)5.24079573
8Orchitis (HP:0100796)5.10750301
9Encephalitis (HP:0002383)4.88699393
10Abnormality of the nasal mucosa (HP:0000433)4.88431316
11Recurrent bronchitis (HP:0002837)4.67676455
12IgM deficiency (HP:0002850)4.51779495
13Keratoconjunctivitis sicca (HP:0001097)4.49196506
14Combined immunodeficiency (HP:0005387)4.42039342
15Elevated erythrocyte sedimentation rate (HP:0003565)4.14125894
16Severe combined immunodeficiency (HP:0004430)4.10522898
17Keratoconjunctivitis (HP:0001096)4.07506623
18Pulmonary infiltrates (HP:0002113)3.88700555
19Chronic otitis media (HP:0000389)3.87536773
20Meningitis (HP:0001287)3.81631774
21Pulmonary embolism (HP:0002204)3.65036065
22Congenital stationary night blindness (HP:0007642)3.61944947
23Joint swelling (HP:0001386)3.61132144
24Hemoptysis (HP:0002105)3.58985973
25Pustule (HP:0200039)3.51577524
26Vasculitis (HP:0002633)3.49872965
27IgG deficiency (HP:0004315)3.41076802
28Chronic obstructive pulmonary disease (HP:0006510)3.39569255
29Obstructive lung disease (HP:0006536)3.39569255
30Eczematoid dermatitis (HP:0000976)3.35030566
31Gangrene (HP:0100758)3.32010547
32Arterial thrombosis (HP:0004420)3.28096039
33Recurrent fungal infections (HP:0002841)3.25206343
34Recurrent viral infections (HP:0004429)3.24947507
35Autoimmune hemolytic anemia (HP:0001890)3.24618456
36Abnormality of T cell physiology (HP:0011840)3.23895000
37Abnormal delayed hypersensitivity skin test (HP:0002963)3.21093131
38Recurrent abscess formation (HP:0002722)3.14426384
39Increased IgM level (HP:0003496)3.13629319
40Ureteral stenosis (HP:0000071)2.99340898
41Abnormality of the prostate (HP:0008775)2.98625043
42Autoimmune thrombocytopenia (HP:0001973)2.98370837
43Gastrointestinal infarctions (HP:0005244)2.97919978
44Lymphopenia (HP:0001888)2.95298091
45Abnormality of oral frenula (HP:0000190)2.86918080
46Hemiplegia (HP:0002301)2.83600183
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.82956633
48Panhypogammaglobulinemia (HP:0003139)2.80854371
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.79383079
50Abnormality of eosinophils (HP:0001879)2.72061724
51Spontaneous hematomas (HP:0007420)2.69555722
52Ureteral obstruction (HP:0006000)2.68671219
53Leukocytosis (HP:0001974)2.68324421
54Chest pain (HP:0100749)2.64043314
55Bronchitis (HP:0012387)2.63298731
56Recurrent sinusitis (HP:0011108)2.62600860
57Abnormality of B cell number (HP:0010975)2.62319072
58B lymphocytopenia (HP:0010976)2.62319072
59Purpura (HP:0000979)2.62117295
60Stomatitis (HP:0010280)2.61342227
61Stomach cancer (HP:0012126)2.58201109
62Epistaxis (HP:0000421)2.55015245
63Increased IgE level (HP:0003212)2.53958581
64Anorexia (HP:0002039)2.53773619
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51977893
66Abnormal rod and cone electroretinograms (HP:0008323)2.50633694
67Abnormality of macrophages (HP:0004311)2.49379413
68Inflammation of the large intestine (HP:0002037)2.47715711
69Attenuation of retinal blood vessels (HP:0007843)2.47469851
70Glomerulopathy (HP:0100820)2.47440532
71Polyneuropathy (HP:0001271)2.42856567
72Petechiae (HP:0000967)2.42652266
73Hypoplasia of the thymus (HP:0000778)2.41619813
74Hypergammaglobulinemia (HP:0010702)2.39990900
75Acute hepatic failure (HP:0006554)2.37630971
76Gastrointestinal inflammation (HP:0004386)2.37392708
77IgA deficiency (HP:0002720)2.36696338
78Abnormality of the fingertips (HP:0001211)2.35968241
79Recurrent cutaneous fungal infections (HP:0011370)2.34276683
80Chronic mucocutaneous candidiasis (HP:0002728)2.34276683
81Agammaglobulinemia (HP:0004432)2.33053095
82Eosinophilia (HP:0001880)2.30888073
83Fatigue (HP:0012378)2.29283198
84Abnormal platelet volume (HP:0011876)2.28725248
853-Methylglutaconic aciduria (HP:0003535)2.28020567
86Abnormality of the pericardium (HP:0001697)2.27053686
87Prolonged bleeding time (HP:0003010)2.26053682
88Exertional dyspnea (HP:0002875)2.24288980
89Keratitis (HP:0000491)2.23809608
90Aortic dissection (HP:0002647)2.20083465
91Abnormality of binocular vision (HP:0011514)2.16899350
92Diplopia (HP:0000651)2.16899350
93Abnormality of the pleura (HP:0002103)2.16217596
94Gingival bleeding (HP:0000225)2.14971776
95Thyroiditis (HP:0100646)2.12942854
96Pancreatic cysts (HP:0001737)2.11392206
97Lymphoma (HP:0002665)2.09071612
98Recurrent bacterial skin infections (HP:0005406)2.06863360
99Mediastinal lymphadenopathy (HP:0100721)2.05511907
100Basal cell carcinoma (HP:0002671)2.04905087
101Abnormality of the renal cortex (HP:0011035)2.04506988
102Chronic diarrhea (HP:0002028)2.03550177
103Abnormality of midbrain morphology (HP:0002418)2.03010656
104Molar tooth sign on MRI (HP:0002419)2.03010656
105Papilledema (HP:0001085)2.02729360
106Thrombophlebitis (HP:0004418)2.02168912
107Chronic sinusitis (HP:0011109)2.01335149
108Hypoproteinemia (HP:0003075)2.00962831
109Recurrent otitis media (HP:0000403)2.00788113
110Mitochondrial inheritance (HP:0001427)2.00312251
111Oligodactyly (hands) (HP:0001180)1.99127581
112Aortic aneurysm (HP:0004942)1.98738877
113Hepatocellular necrosis (HP:0001404)1.95147809
114Severe visual impairment (HP:0001141)1.94069547
115Granulocytopenia (HP:0001913)1.92256308
116Abolished electroretinogram (ERG) (HP:0000550)1.91114074
117Dilatation of the ascending aorta (HP:0005111)1.90974474
118Recurrent skin infections (HP:0001581)1.90828278
119Papilloma (HP:0012740)1.90471996
120Verrucae (HP:0200043)1.90471996
121Arthralgia (HP:0002829)1.89139584
122Constricted visual fields (HP:0001133)1.89057227
123Volvulus (HP:0002580)1.85679851
124Neutropenia (HP:0001875)1.84162700
125Pancreatic fibrosis (HP:0100732)1.76212398
126Decreased central vision (HP:0007663)1.74098346
127True hermaphroditism (HP:0010459)1.72184556
128Pancytopenia (HP:0001876)1.71981166
129Increased CSF lactate (HP:0002490)1.70366553
130Prostate neoplasm (HP:0100787)1.70170118
131Hepatic necrosis (HP:0002605)1.70008765
132Aplastic anemia (HP:0001915)1.68863887
133Progressive microcephaly (HP:0000253)1.66126837
134Abnormal albumin level (HP:0012116)1.64661577
135Hypoalbuminemia (HP:0003073)1.64661577
136Pendular nystagmus (HP:0012043)1.62235163
137Amyotrophic lateral sclerosis (HP:0007354)1.60105369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.44603034
2MAP4K14.48342092
3ITK4.03382449
4JAK33.35511966
5MAP4K23.00683653
6JAK12.90488800
7ZAP702.84326298
8STK102.71378687
9FRK2.58108850
10CSK2.25460489
11TYK22.19145360
12ZAK2.17243806
13GRK62.10822591
14MST42.02942628
15FGFR41.95977683
16LCK1.91448003
17CAMKK21.84965167
18IKBKE1.82798380
19FES1.76268649
20MAP3K141.56550105
21WNK41.54618807
22BCKDK1.43931973
23SYK1.43260403
24TLK11.41053790
25TGFBR21.39874040
26PRKCQ1.38545552
27CLK11.38376193
28FGFR31.38228502
29BLK1.37973684
30PRKCH1.33355663
31TBK11.31123562
32MAP3K111.30018520
33NUAK11.29792033
34RIPK41.28156137
35LRRK21.25630554
36PINK11.24405069
37TEC1.20820985
38DMPK1.17917186
39GRK71.12839365
40MAP3K121.12631964
41HCK1.11395096
42BMPR21.10634923
43BMPR1B1.10583381
44TYRO31.09641917
45TRIB31.07700460
46GRK11.06338118
47TESK21.05292553
48TTN1.02779447
49BTK1.01399349
50IRAK41.00307385
51TNK21.00049764
52WNK30.97722190
53ACVR1B0.97371429
54TAOK30.94983476
55JAK20.94676425
56MARK30.94094670
57VRK20.93951861
58CDK90.92600943
59MAP2K30.91672269
60MAP3K130.91491153
61RIPK10.91238126
62NLK0.89931087
63STK240.84863135
64KDR0.83283853
65IKBKB0.79573076
66NME10.77701828
67PIM10.76727725
68VRK10.75915054
69ERBB30.74860711
70GRK50.73453831
71INSRR0.72619773
72ALK0.72608018
73MELK0.70435321
74MAPK130.70128438
75ILK0.70103778
76PTK2B0.69976402
77CDK40.69560039
78EPHB10.67729247
79PTK20.62992244
80LYN0.61843155
81CAMKK10.61292325
82RAF10.60746476
83NME20.59694832
84ADRBK10.59022235
85MAP3K30.58599966
86SIK20.58078508
87TAOK20.57951317
88NEK90.57307249
89PDGFRB0.55848161
90FYN0.54889542
91OXSR10.52920442
92PDK10.52727225
93KIT0.50195347
94SRPK10.49855926
95CDK60.49544828
96PIK3CA0.46356651
97STK390.45396341
98MAP3K50.44893949
99INSR0.44501830
100STK380.44055384
101CDK190.43925960
102BRSK20.42814351
103EPHA30.41849494
104ADRBK20.41688462
105MAP2K60.40887488
106CSF1R0.40408302
107MAP3K70.40021481
108STK160.39762904
109BCR0.38323310
110IGF1R0.35860328
111ABL10.35714202
112MAPK110.35416876
113ROCK20.35067751
114STK40.35014231
115PRKD20.34387500
116RPS6KA40.33462423
117MAP3K100.32536084
118HIPK20.31548143
119CSNK1A1L0.31264891
120RPS6KA50.30830926
121MAPK70.30687519
122TAOK10.30455977
123LIMK10.30255451
124PASK0.30044945
125CSNK1G10.29229686
126STK110.29228510
127PIK3CG0.27637267
128MAP2K20.27367016
129CSNK1G30.26923674
130FGR0.26892672
131CSNK1G20.26070639
132CSNK1D0.25950074
133CDK30.25781111
134TNIK0.25405268
135GSK3A0.25385941
136CHUK0.25304704
137PKN20.24153776
138IRAK10.23479235
139MAPK120.23200119
140PRKCD0.22864772
141PAK30.19995825
142MYLK0.19652397
143MAPK30.19622577
144SRC0.19582132
145MAPKAPK20.18695353

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.86064360
2Allograft rejection_Homo sapiens_hsa053304.66460440
3Autoimmune thyroid disease_Homo sapiens_hsa053204.24316579
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.23070260
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.14174424
6Primary immunodeficiency_Homo sapiens_hsa053403.96531864
7Asthma_Homo sapiens_hsa053103.61829163
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.57439885
9T cell receptor signaling pathway_Homo sapiens_hsa046603.27233468
10Antigen processing and presentation_Homo sapiens_hsa046122.94504304
11Proteasome_Homo sapiens_hsa030502.22837848
12Measles_Homo sapiens_hsa051622.14717562
13Viral myocarditis_Homo sapiens_hsa054162.05782835
14Phototransduction_Homo sapiens_hsa047441.96468540
15Hematopoietic cell lineage_Homo sapiens_hsa046401.86031452
16Oxidative phosphorylation_Homo sapiens_hsa001901.74550128
17Leishmaniasis_Homo sapiens_hsa051401.72480941
18RNA polymerase_Homo sapiens_hsa030201.61930220
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58768034
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.56942304
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52047886
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47635773
23Parkinsons disease_Homo sapiens_hsa050121.44993948
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37336874
25Type I diabetes mellitus_Homo sapiens_hsa049401.35659710
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32377887
27Nitrogen metabolism_Homo sapiens_hsa009101.32183741
28Osteoclast differentiation_Homo sapiens_hsa043801.31346880
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28894618
30Staphylococcus aureus infection_Homo sapiens_hsa051501.28421122
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.24820769
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23979016
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.22810881
34Chemokine signaling pathway_Homo sapiens_hsa040621.22519040
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19614968
36Homologous recombination_Homo sapiens_hsa034401.16778318
37B cell receptor signaling pathway_Homo sapiens_hsa046621.16108482
38Shigellosis_Homo sapiens_hsa051311.12234918
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10040403
40Linoleic acid metabolism_Homo sapiens_hsa005911.06841402
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05378454
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05299598
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04403637
44Fanconi anemia pathway_Homo sapiens_hsa034601.03532133
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02789346
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98868331
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97058379
48Malaria_Homo sapiens_hsa051440.96254719
49RNA degradation_Homo sapiens_hsa030180.91924514
50Regulation of autophagy_Homo sapiens_hsa041400.90853227
51Pancreatic cancer_Homo sapiens_hsa052120.90315307
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90073664
53Toxoplasmosis_Homo sapiens_hsa051450.87757715
54Alzheimers disease_Homo sapiens_hsa050100.86804886
55Platelet activation_Homo sapiens_hsa046110.84481767
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80306182
57Apoptosis_Homo sapiens_hsa042100.79326139
58Protein export_Homo sapiens_hsa030600.77498013
59Rheumatoid arthritis_Homo sapiens_hsa053230.76763282
60Huntingtons disease_Homo sapiens_hsa050160.72722472
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72203142
62Hepatitis B_Homo sapiens_hsa051610.71047463
63TNF signaling pathway_Homo sapiens_hsa046680.70527345
64Pertussis_Homo sapiens_hsa051330.70258580
65Butanoate metabolism_Homo sapiens_hsa006500.68499799
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67401453
67Herpes simplex infection_Homo sapiens_hsa051680.67294019
68Influenza A_Homo sapiens_hsa051640.63278724
69Basal transcription factors_Homo sapiens_hsa030220.62316513
70Taste transduction_Homo sapiens_hsa047420.61783021
71VEGF signaling pathway_Homo sapiens_hsa043700.61568395
72Colorectal cancer_Homo sapiens_hsa052100.60419248
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59607822
74Olfactory transduction_Homo sapiens_hsa047400.59390967
75HTLV-I infection_Homo sapiens_hsa051660.58808960
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57489100
77Chronic myeloid leukemia_Homo sapiens_hsa052200.57135558
78Tuberculosis_Homo sapiens_hsa051520.56946133
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56823822
80Renal cell carcinoma_Homo sapiens_hsa052110.56066316
81Caffeine metabolism_Homo sapiens_hsa002320.56015163
82Propanoate metabolism_Homo sapiens_hsa006400.54010326
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51512576
84Acute myeloid leukemia_Homo sapiens_hsa052210.49841175
85Morphine addiction_Homo sapiens_hsa050320.49192324
86Ether lipid metabolism_Homo sapiens_hsa005650.48624020
87Purine metabolism_Homo sapiens_hsa002300.48517086
88DNA replication_Homo sapiens_hsa030300.48333901
89Peroxisome_Homo sapiens_hsa041460.47583400
90Legionellosis_Homo sapiens_hsa051340.47517301
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.46237434
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45086956
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.44923465
94Non-small cell lung cancer_Homo sapiens_hsa052230.44437226
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41881046
96Rap1 signaling pathway_Homo sapiens_hsa040150.41867087
97Arachidonic acid metabolism_Homo sapiens_hsa005900.41645981
98Salmonella infection_Homo sapiens_hsa051320.41376225
99Focal adhesion_Homo sapiens_hsa045100.39464575
100Ribosome_Homo sapiens_hsa030100.39338043
101Hepatitis C_Homo sapiens_hsa051600.38574599
102Pyrimidine metabolism_Homo sapiens_hsa002400.38425695
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37399399
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.37138578
105Epstein-Barr virus infection_Homo sapiens_hsa051690.37101884
106Endocytosis_Homo sapiens_hsa041440.36888574
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.36758419
108Prolactin signaling pathway_Homo sapiens_hsa049170.36620142
109Prion diseases_Homo sapiens_hsa050200.36386648
110FoxO signaling pathway_Homo sapiens_hsa040680.36326729
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35997176
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35167944
113Cardiac muscle contraction_Homo sapiens_hsa042600.34471100
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33519698
115ABC transporters_Homo sapiens_hsa020100.33094522
116p53 signaling pathway_Homo sapiens_hsa041150.32535658
117Spliceosome_Homo sapiens_hsa030400.31943661
118Collecting duct acid secretion_Homo sapiens_hsa049660.30405825
119Selenocompound metabolism_Homo sapiens_hsa004500.29795421
120Chemical carcinogenesis_Homo sapiens_hsa052040.28306912
121Tryptophan metabolism_Homo sapiens_hsa003800.26870819
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26625473
123Viral carcinogenesis_Homo sapiens_hsa052030.25542058
124Base excision repair_Homo sapiens_hsa034100.25474220
125One carbon pool by folate_Homo sapiens_hsa006700.23992081
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23809335
127Long-term potentiation_Homo sapiens_hsa047200.21123161
128MAPK signaling pathway_Homo sapiens_hsa040100.20593876
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20312063
130Dilated cardiomyopathy_Homo sapiens_hsa054140.18335270
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.16570779
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15988011
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15551882
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12012498
135Inositol phosphate metabolism_Homo sapiens_hsa005620.11113437
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10793725
137Small cell lung cancer_Homo sapiens_hsa052220.09433374
138Amoebiasis_Homo sapiens_hsa051460.08764505
139mTOR signaling pathway_Homo sapiens_hsa041500.07985154
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.07967575
141Ras signaling pathway_Homo sapiens_hsa040140.07874544
142Choline metabolism in cancer_Homo sapiens_hsa052310.06994281
143Dorso-ventral axis formation_Homo sapiens_hsa043200.05277779
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05172197
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04461632
146Insulin resistance_Homo sapiens_hsa049310.03871998
147Adherens junction_Homo sapiens_hsa045200.02865650
148Non-homologous end-joining_Homo sapiens_hsa034500.02528542
149Other glycan degradation_Homo sapiens_hsa005110.02363563
150African trypanosomiasis_Homo sapiens_hsa051430.02227492
151Endometrial cancer_Homo sapiens_hsa052130.01913876
152Notch signaling pathway_Homo sapiens_hsa04330-0.0009066
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0005353

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