KLRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.41875303
2interferon-gamma production (GO:0032609)7.39258470
3negative thymic T cell selection (GO:0045060)7.27670356
4positive regulation of gamma-delta T cell activation (GO:0046645)7.24109453
5cellular response to interleukin-15 (GO:0071350)7.21981968
6regulation of isotype switching to IgG isotypes (GO:0048302)7.19914838
7positive thymic T cell selection (GO:0045059)6.63634074
8T cell migration (GO:0072678)6.23883323
9response to interleukin-15 (GO:0070672)6.16877300
10cytidine deamination (GO:0009972)6.04898931
11cytidine metabolic process (GO:0046087)6.04898931
12cytidine catabolic process (GO:0006216)6.04898931
13positive T cell selection (GO:0043368)5.71358713
14thymic T cell selection (GO:0045061)5.60393502
15regulation of gamma-delta T cell differentiation (GO:0045586)5.54508574
16positive regulation of isotype switching (GO:0045830)5.52809769
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.52583445
18pyrimidine ribonucleoside catabolic process (GO:0046133)5.46488471
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.45144391
20DNA deamination (GO:0045006)5.36143233
21regulation of B cell receptor signaling pathway (GO:0050855)5.26384761
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21691637
23negative regulation of T cell mediated immunity (GO:0002710)5.20975563
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.18124886
25regulation of gamma-delta T cell activation (GO:0046643)5.14851786
26positive regulation of DNA recombination (GO:0045911)5.14459792
27positive regulation of alpha-beta T cell proliferation (GO:0046641)4.98737008
28T cell selection (GO:0045058)4.85555204
29positive regulation of B cell mediated immunity (GO:0002714)4.81750799
30positive regulation of immunoglobulin mediated immune response (GO:0002891)4.81750799
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.80277336
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80277336
33* regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.76132005
34* regulation of natural killer cell mediated immunity (GO:0002715)4.76132005
35positive regulation of humoral immune response (GO:0002922)4.72867515
36leukocyte aggregation (GO:0070486)4.66303530
37cellular defense response (GO:0006968)4.65891422
38regulation of alpha-beta T cell proliferation (GO:0046640)4.62964878
39* regulation of leukocyte mediated cytotoxicity (GO:0001910)4.62161725
40regulation of activation of Janus kinase activity (GO:0010533)4.51643878
41activated T cell proliferation (GO:0050798)4.50287663
42lymphocyte migration (GO:0072676)4.49362427
43antigen processing and presentation of endogenous antigen (GO:0019883)4.45331253
44regulation of T cell mediated cytotoxicity (GO:0001914)4.45320739
45Arp2/3 complex-mediated actin nucleation (GO:0034314)4.42047599
46sequestering of actin monomers (GO:0042989)4.35255981
47* regulation of cell killing (GO:0031341)4.16689647
48regulation of isotype switching (GO:0045191)4.15954354
49positive regulation of B cell differentiation (GO:0045579)4.14557411
50positive regulation of T cell mediated cytotoxicity (GO:0001916)4.13648801
51regulation of regulatory T cell differentiation (GO:0045589)4.12586594
52negative regulation of lymphocyte mediated immunity (GO:0002707)4.09800979
53regulation of immunoglobulin mediated immune response (GO:0002889)3.99403609
54mast cell activation (GO:0045576)3.97700067
55positive regulation of tolerance induction (GO:0002645)3.95756506
56* natural killer cell activation (GO:0030101)3.92369257
57* positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89479004
58regulation of B cell mediated immunity (GO:0002712)3.88991411
59neutrophil activation (GO:0042119)3.87993388
60actin nucleation (GO:0045010)3.87654182
61regulation of T cell tolerance induction (GO:0002664)3.87320074
62cytolysis (GO:0019835)3.87000300
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.80993764
64T cell receptor signaling pathway (GO:0050852)3.80693525
65regulation of B cell differentiation (GO:0045577)3.78142975
66negative regulation of T cell apoptotic process (GO:0070233)3.78032575
67neutrophil activation involved in immune response (GO:0002283)3.77224291
68regulation of hypersensitivity (GO:0002883)3.74390716
69positive regulation of calcium-mediated signaling (GO:0050850)3.73757794
70antigen processing and presentation via MHC class Ib (GO:0002475)3.72441454
71T cell differentiation involved in immune response (GO:0002292)3.67337966
72alpha-beta T cell differentiation involved in immune response (GO:0002293)3.67337966
73alpha-beta T cell activation involved in immune response (GO:0002287)3.67337966
74regulation of tolerance induction (GO:0002643)3.64961412
75negative regulation of viral genome replication (GO:0045071)3.63686058
76leukocyte cell-cell adhesion (GO:0007159)3.61008663
77T-helper cell differentiation (GO:0042093)3.58338729
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.58338729
79* positive regulation of cell killing (GO:0031343)3.56761731
80granulocyte activation (GO:0036230)3.56635446
81* positive regulation of natural killer cell mediated immunity (GO:0002717)3.56412492
82* positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.56412492
83* T cell costimulation (GO:0031295)3.55981306
84positive regulation of immunoglobulin production (GO:0002639)3.55807882
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.54338618
86T cell proliferation (GO:0042098)3.52356412
87regulation of response to tumor cell (GO:0002834)3.50424410
88positive regulation of response to tumor cell (GO:0002836)3.50424410
89positive regulation of immune response to tumor cell (GO:0002839)3.50424410
90regulation of immune response to tumor cell (GO:0002837)3.50424410
91* lymphocyte costimulation (GO:0031294)3.49851305
92heterotypic cell-cell adhesion (GO:0034113)3.48663680
93regulation of T cell receptor signaling pathway (GO:0050856)3.46052274
94regulation of T cell chemotaxis (GO:0010819)3.44850237
95positive regulation of T cell chemotaxis (GO:0010820)3.44850237
96negative regulation of leukocyte mediated immunity (GO:0002704)3.41807738
97negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.41778404
98positive regulation of granulocyte differentiation (GO:0030854)3.40427481
99* regulation of lymphocyte mediated immunity (GO:0002706)3.39186440
100positive regulation of T-helper 1 type immune response (GO:0002827)3.37280253
101antigen receptor-mediated signaling pathway (GO:0050851)3.36892583
102cellular response to zinc ion (GO:0071294)3.36537148
103type I interferon signaling pathway (GO:0060337)3.33733482
104cellular response to type I interferon (GO:0071357)3.33733482
105interferon-gamma-mediated signaling pathway (GO:0060333)3.33213759
106response to type I interferon (GO:0034340)3.33025192
107lymphocyte chemotaxis (GO:0048247)3.32579153
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.31046736
109T cell activation involved in immune response (GO:0002286)3.27305685
110* positive regulation of lymphocyte mediated immunity (GO:0002708)3.24994110
111positive regulation of defense response to virus by host (GO:0002230)3.24260825
112cellular extravasation (GO:0045123)3.23074169
113alpha-beta T cell activation (GO:0046631)3.22864138
114regulation of response to interferon-gamma (GO:0060330)3.21603309
115regulation of memory T cell differentiation (GO:0043380)3.19602892
116positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.19236608
117dendritic cell chemotaxis (GO:0002407)3.19143246
118positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17079708
119positive regulation of T cell mediated immunity (GO:0002711)3.17002228
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.16344886
121T cell differentiation (GO:0030217)3.10615648
122respiratory burst (GO:0045730)3.06589344
123B cell receptor signaling pathway (GO:0050853)3.06264819
124regulation of interleukin-2 biosynthetic process (GO:0045076)3.05813567
125regulation of T cell mediated immunity (GO:0002709)3.02176615
126mast cell activation involved in immune response (GO:0002279)3.01929855
127mast cell degranulation (GO:0043303)3.01929855
128immunoglobulin mediated immune response (GO:0016064)3.01279366
129T cell activation (GO:0042110)2.96528235
130chemokine-mediated signaling pathway (GO:0070098)2.96464474
131regulation of lymphocyte chemotaxis (GO:1901623)2.92851583
132response to interferon-beta (GO:0035456)2.91934599
133negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89724048
134natural killer cell differentiation (GO:0001779)2.85536095
135positive regulation of interleukin-8 secretion (GO:2000484)2.85447902
136regulation of calcium-mediated signaling (GO:0050848)2.83837875
137negative regulation of leukocyte mediated cytotoxicity (GO:0001911)10.5268435
138negative regulation of cell killing (GO:0031342)10.5268435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.66801272
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.32803013
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.25297933
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.95929033
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.68987650
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.65640471
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.51143715
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.28732139
9RUNX_20019798_ChIP-Seq_JUKART_Human3.70216791
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.40190667
11MYB_26560356_Chip-Seq_TH2_Human3.29513279
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26781252
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.08944004
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99115874
15MAF_26560356_Chip-Seq_TH1_Human2.86961177
16MYB_26560356_Chip-Seq_TH1_Human2.75646917
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.68110030
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.50509549
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.47602447
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45048607
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40945743
22UTX_26944678_Chip-Seq_JUKART_Human2.24979396
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17638688
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14983030
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.08872220
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05990431
27SPI1_23547873_ChIP-Seq_NB4_Human2.03740799
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.02144902
29GATA3_27048872_Chip-Seq_THYMUS_Human1.99000173
30VDR_22108803_ChIP-Seq_LS180_Human1.91322764
31MYC_22102868_ChIP-Seq_BL_Human1.84372109
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75289338
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74986017
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74223770
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72079790
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70857764
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67304263
38MAF_26560356_Chip-Seq_TH2_Human1.67289146
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63097513
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.60560910
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56803491
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55966708
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51613918
44VDR_24763502_ChIP-Seq_THP-1_Human1.50760107
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49749549
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49228258
47GATA3_26560356_Chip-Seq_TH2_Human1.48675541
48TCF7_22412390_ChIP-Seq_EML_Mouse1.47067870
49SCL_19346495_ChIP-Seq_HPC-7_Human1.41015126
50PU_27001747_Chip-Seq_BMDM_Mouse1.39265512
51VDR_21846776_ChIP-Seq_THP-1_Human1.38560358
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36380564
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.35424319
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34932160
55SPI1_23127762_ChIP-Seq_K562_Human1.34462227
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30618957
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30288883
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29442618
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29233299
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26115655
61VDR_23849224_ChIP-Seq_CD4+_Human1.25456005
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24622967
63* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23111988
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20281027
65TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16696495
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16442951
67VDR_24787735_ChIP-Seq_THP-1_Human1.15131531
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12766892
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12700189
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11225044
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11018976
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10698684
73IGF1R_20145208_ChIP-Seq_DFB_Human1.10498519
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10398630
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07101687
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05899265
77GATA3_26560356_Chip-Seq_TH1_Human1.05225145
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01878339
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00834345
80EGR1_19032775_ChIP-ChIP_M12_Human1.00581777
81GATA1_22025678_ChIP-Seq_K562_Human0.99045320
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97264446
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95705983
84KDM2B_26808549_Chip-Seq_DND41_Human0.95257934
85NANOG_20526341_ChIP-Seq_ESCs_Human0.92776673
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90903082
87TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.90768164
88ER_23166858_ChIP-Seq_MCF-7_Human0.90200828
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89168494
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88722712
91AR_20517297_ChIP-Seq_VCAP_Human0.88375352
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.88260902
93BCL6_27268052_Chip-Seq_Bcells_Human0.87391975
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87004661
95* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86607030
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86224098
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.85948340
98BCAT_22108803_ChIP-Seq_LS180_Human0.85484087
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85195595
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84924839
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84466980
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84459012
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83633187
104CRX_20693478_ChIP-Seq_RETINA_Mouse0.82927452
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82831843
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82696982
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82657825
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82270073
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81582162
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.81258239
111ELK3_25401928_ChIP-Seq_HUVEC_Human0.80110719
112FOXP3_21729870_ChIP-Seq_TREG_Human0.77523510
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77231410
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.76478530
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.76478530
116TP53_22573176_ChIP-Seq_HFKS_Human0.76284397
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76245455
118GATA3_21878914_ChIP-Seq_MCF-7_Human0.76223420
119ZNF274_21170338_ChIP-Seq_K562_Hela0.76074513
120GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75791382
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.75535744
122P300_27268052_Chip-Seq_Bcells_Human0.75472660
123GATA2_21666600_ChIP-Seq_HMVEC_Human0.75446484
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75192576
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74841019
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73799823
127CIITA_25753668_ChIP-Seq_RAJI_Human0.73431873
128* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72813591
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72402077
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70265617
131SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.69283667
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66518230
133SPI1_20517297_ChIP-Seq_HL60_Human0.64169192
134RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63312277
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.61812267
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.60131043
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.59306173
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.59067320
139SMRT_27268052_Chip-Seq_Bcells_Human0.58708004
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.57857707
141GATA2_19941826_ChIP-Seq_K562_Human0.57703990
142* FLI1_21867929_ChIP-Seq_CD8_Mouse0.57038268
143NCOR1_26117541_ChIP-Seq_K562_Human0.53825146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.35652652
2MP0006082_CNS_inflammation5.23816513
3MP0001835_abnormal_antigen_presentation4.37659878
4MP0003763_abnormal_thymus_physiology4.09626364
5* MP0009785_altered_susceptibility_to3.61485586
6MP0000685_abnormal_immune_system3.42997701
7MP0001790_abnormal_immune_system3.32679822
8MP0005387_immune_system_phenotype3.32679822
9MP0001800_abnormal_humoral_immune3.22736660
10MP0005000_abnormal_immune_tolerance3.20159110
11* MP0005025_abnormal_response_to3.11179264
12* MP0001819_abnormal_immune_cell2.95635033
13* MP0002420_abnormal_adaptive_immunity2.95513330
14* MP0002723_abnormal_immune_serum2.89976393
15MP0002148_abnormal_hypersensitivity_rea2.79229520
16MP0002452_abnormal_antigen_presenting2.72620141
17MP0002405_respiratory_system_inflammati2.58111234
18MP0002166_altered_tumor_susceptibility2.57311406
19MP0002006_tumorigenesis2.46503076
20MP0003448_altered_tumor_morphology2.45799740
21MP0000858_altered_metastatic_potential2.38994926
22* MP0002398_abnormal_bone_marrow2.38918339
23MP0003436_decreased_susceptibility_to2.36729846
24MP0002419_abnormal_innate_immunity2.34802371
25* MP0000716_abnormal_immune_system2.27586590
26MP0003724_increased_susceptibility_to2.14300716
27MP0009333_abnormal_splenocyte_physiolog2.14136291
28MP0002132_abnormal_respiratory_system2.12203276
29MP0010155_abnormal_intestine_physiology1.96129223
30* MP0002722_abnormal_immune_system1.89549322
31MP0000703_abnormal_thymus_morphology1.88395077
32MP0002138_abnormal_hepatobiliary_system1.86404493
33MP0004947_skin_inflammation1.85149027
34MP0001845_abnormal_inflammatory_respons1.82157994
35MP0004510_myositis1.81726311
36* MP0000689_abnormal_spleen_morphology1.76473070
37* MP0002429_abnormal_blood_cell1.75736528
38MP0001873_stomach_inflammation1.75598754
39MP0005310_abnormal_salivary_gland1.54576204
40MP0003045_fibrosis1.54275121
41MP0003866_abnormal_defecation1.54084917
42MP0005464_abnormal_platelet_physiology1.49764080
43MP0008469_abnormal_protein_level1.45078001
44MP0002009_preneoplasia1.44954827
45MP0002933_joint_inflammation1.38883733
46MP0001853_heart_inflammation1.34067259
47MP0002998_abnormal_bone_remodeling1.30109830
48MP0001851_eye_inflammation1.21872062
49MP0001533_abnormal_skeleton_physiology1.21363899
50MP0002876_abnormal_thyroid_physiology1.11420896
51MP0009764_decreased_sensitivity_to1.11161457
52MP0001348_abnormal_lacrimal_gland1.11135542
53MP0004381_abnormal_hair_follicle1.10414862
54MP0005645_abnormal_hypothalamus_physiol1.08890696
55MP0003300_gastrointestinal_ulcer1.06952586
56MP0009763_increased_sensitivity_to1.06071278
57MP0005166_decreased_susceptibility_to1.03632436
58MP0002163_abnormal_gland_morphology1.02954028
59* MP0002019_abnormal_tumor_incidence1.02658873
60MP0001919_abnormal_reproductive_system1.01417885
61MP0002396_abnormal_hematopoietic_system1.00136013
62MP0010307_abnormal_tumor_latency0.99249704
63MP0001986_abnormal_taste_sensitivity0.92428650
64MP0000613_abnormal_salivary_gland0.91050631
65MP0003646_muscle_fatigue0.89091760
66MP0003878_abnormal_ear_physiology0.88398264
67MP0005377_hearing/vestibular/ear_phenot0.88398264
68MP0000920_abnormal_myelination0.86857936
69MP0003787_abnormal_imprinting0.86524869
70MP0000569_abnormal_digit_pigmentation0.86337647
71MP0003303_peritoneal_inflammation0.84742749
72MP0003195_calcinosis0.84166022
73MP0001765_abnormal_ion_homeostasis0.83725645
74MP0000343_altered_response_to0.80476512
75MP0008872_abnormal_physiological_respon0.80087894
76MP0000490_abnormal_crypts_of0.78046008
77MP0008877_abnormal_DNA_methylation0.75283923
78MP0005451_abnormal_body_composition0.74395049
79MP0003786_premature_aging0.73925872
80MP0002638_abnormal_pupillary_reflex0.73180463
81MP0005075_abnormal_melanosome_morpholog0.73177765
82MP0003950_abnormal_plasma_membrane0.71015257
83MP0004130_abnormal_muscle_cell0.70536824
84MP0008995_early_reproductive_senescence0.69637063
85MP0002102_abnormal_ear_morphology0.66069745
86MP0003252_abnormal_bile_duct0.65736216
87MP0002136_abnormal_kidney_physiology0.63663821
88MP0001501_abnormal_sleep_pattern0.63563707
89MP0000372_irregular_coat_pigmentation0.63151720
90MP0000015_abnormal_ear_pigmentation0.62850984
91MP0001905_abnormal_dopamine_level0.60643853
92MP0003011_delayed_dark_adaptation0.60525751
93MP0005389_reproductive_system_phenotype0.58779172
94MP0003172_abnormal_lysosome_physiology0.58165639
95MP0003690_abnormal_glial_cell0.56535204
96MP0004142_abnormal_muscle_tone0.56367027
97MP0002095_abnormal_skin_pigmentation0.56328652
98MP0001663_abnormal_digestive_system0.55938906
99MP0001881_abnormal_mammary_gland0.54871585
100MP0004808_abnormal_hematopoietic_stem0.54488497
101MP0005397_hematopoietic_system_phenotyp0.53306247
102MP0001545_abnormal_hematopoietic_system0.53306247
103MP0005379_endocrine/exocrine_gland_phen0.53218944
104MP0008875_abnormal_xenobiotic_pharmacok0.53168642
105MP0004883_abnormal_blood_vessel0.53063759
106MP0003453_abnormal_keratinocyte_physiol0.52964236
107MP0002693_abnormal_pancreas_physiology0.52949715
108MP0005551_abnormal_eye_electrophysiolog0.52901748
109MP0009765_abnormal_xenobiotic_induced0.51433036
110MP0005410_abnormal_fertilization0.50995283
111MP0004742_abnormal_vestibular_system0.50154778
112MP0005174_abnormal_tail_pigmentation0.48702778
113MP0000465_gastrointestinal_hemorrhage0.48328014
114MP0000609_abnormal_liver_physiology0.47657226
115MP0008057_abnormal_DNA_replication0.45117727
116MP0000249_abnormal_blood_vessel0.45024416
117MP0002277_abnormal_respiratory_mucosa0.44808482
118MP0003566_abnormal_cell_adhesion0.43719945
119MP0005076_abnormal_cell_differentiation0.42355183
120MP0003091_abnormal_cell_migration0.42232621
121MP0001191_abnormal_skin_condition0.41840953
122MP0002928_abnormal_bile_duct0.41477988
123MP0002168_other_aberrant_phenotype0.40523595
124MP0005390_skeleton_phenotype0.40408367
125MP0001243_abnormal_dermal_layer0.38829173
126MP0002877_abnormal_melanocyte_morpholog0.38745365
127MP0003183_abnormal_peptide_metabolism0.38639481
128MP0003795_abnormal_bone_structure0.38497110
129MP0000371_diluted_coat_color0.37542618
130MP0000627_abnormal_mammary_gland0.36450893
131MP0002254_reproductive_system_inflammat0.35478419
132MP0005584_abnormal_enzyme/coenzyme_acti0.35281643
133MP0009643_abnormal_urine_homeostasis0.34828543
134MP0008873_increased_physiological_sensi0.34450809

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)7.52588287
2T lymphocytopenia (HP:0005403)7.51333565
3Retrobulbar optic neuritis (HP:0100654)6.15984937
4Optic neuritis (HP:0100653)6.15984937
5Severe combined immunodeficiency (HP:0004430)5.81647677
6Orchitis (HP:0100796)5.50466790
7Myositis (HP:0100614)5.50423870
8Nasal polyposis (HP:0100582)5.46315298
9Combined immunodeficiency (HP:0005387)5.31185917
10Abnormality of T cells (HP:0002843)4.89878260
11Encephalitis (HP:0002383)4.79875402
12Thyroiditis (HP:0100646)4.78565784
13Chronic mucocutaneous candidiasis (HP:0002728)4.60539524
14Recurrent cutaneous fungal infections (HP:0011370)4.60539524
15Abnormality of the nasal mucosa (HP:0000433)4.44871353
16Elevated erythrocyte sedimentation rate (HP:0003565)4.33435040
17Recurrent fungal infections (HP:0002841)4.30601071
18Eczematoid dermatitis (HP:0000976)4.27805017
19Keratoconjunctivitis sicca (HP:0001097)4.23024443
20Recurrent bronchitis (HP:0002837)4.22578923
21Aplastic anemia (HP:0001915)4.09579788
22Recurrent abscess formation (HP:0002722)4.08062964
23Meningitis (HP:0001287)4.01314356
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.93005989
25Abnormality of macrophages (HP:0004311)3.89719360
26Keratoconjunctivitis (HP:0001096)3.84951564
27Abnormality of eosinophils (HP:0001879)3.80863341
28Joint swelling (HP:0001386)3.71798094
29Increased IgM level (HP:0003496)3.68198543
30Gastrointestinal infarctions (HP:0005244)3.67994417
31Vasculitis (HP:0002633)3.57869825
32Agammaglobulinemia (HP:0004432)3.55656173
33Panhypogammaglobulinemia (HP:0003139)3.53839817
34Stomatitis (HP:0010280)3.51248961
35Recurrent viral infections (HP:0004429)3.49928459
36Chronic otitis media (HP:0000389)3.43473034
37Leukocytosis (HP:0001974)3.42873553
38Hypoplasia of the thymus (HP:0000778)3.37418326
39Pulmonary infiltrates (HP:0002113)3.35548718
40Arterial thrombosis (HP:0004420)3.34593039
41Hypoproteinemia (HP:0003075)3.34033672
42IgG deficiency (HP:0004315)3.33077315
43Autoimmune hemolytic anemia (HP:0001890)3.32578225
44Recurrent skin infections (HP:0001581)3.24778476
45Hemoptysis (HP:0002105)3.16949926
46Chronic obstructive pulmonary disease (HP:0006510)3.12396432
47Obstructive lung disease (HP:0006536)3.12396432
48Recurrent bacterial skin infections (HP:0005406)3.08964336
49Mediastinal lymphadenopathy (HP:0100721)3.08433830
50Autoimmune thrombocytopenia (HP:0001973)3.00061151
51Chronic diarrhea (HP:0002028)2.94213157
52Abnormality of B cell number (HP:0010975)2.89799917
53Gangrene (HP:0100758)2.87427907
54Hemiplegia (HP:0002301)2.75404337
55IgM deficiency (HP:0002850)2.71810038
56Anorexia (HP:0002039)2.69891694
57Abnormality of T cell physiology (HP:0011840)2.69629733
58Pulmonary embolism (HP:0002204)2.69451962
59Stomach cancer (HP:0012126)2.60188824
60Inflammation of the large intestine (HP:0002037)2.59399108
61Increased serum ferritin (HP:0003281)2.57482473
62Muscle fiber atrophy (HP:0100295)2.54316927
63Gingivitis (HP:0000230)2.53192772
64Hypoalbuminemia (HP:0003073)2.50858698
65Abnormal albumin level (HP:0012116)2.50858698
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.48086539
67Eosinophilia (HP:0001880)2.46903833
68Lymphopenia (HP:0001888)2.45679214
69Hypergammaglobulinemia (HP:0010702)2.45325276
70Type 2 muscle fiber atrophy (HP:0003554)2.43690248
71Recurrent gram-negative bacterial infections (HP:0005420)2.38855567
72Congenital stationary night blindness (HP:0007642)2.37405594
73Gastrointestinal inflammation (HP:0004386)2.36575880
74Increased IgE level (HP:0003212)2.30637250
75Pustule (HP:0200039)2.27874927
76Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27707891
77Bronchitis (HP:0012387)2.27669717
78Lymphoma (HP:0002665)2.27212853
79Renal cortical cysts (HP:0000803)2.26501536
80Abnormality of the pleura (HP:0002103)2.23353626
81Spontaneous hematomas (HP:0007420)2.21059307
82Abnormality of iron homeostasis (HP:0011031)2.20473326
83Colitis (HP:0002583)2.20435846
84Keratitis (HP:0000491)2.16892463
85Abnormality of the pericardium (HP:0001697)2.15692233
86Abnormality of the prostate (HP:0008775)2.11531386
87Glomerulopathy (HP:0100820)2.10091860
88Acute hepatic failure (HP:0006554)2.08161144
89Pancytopenia (HP:0001876)2.07376914
90Granulocytopenia (HP:0001913)2.02694932
91Chest pain (HP:0100749)2.00801452
92Polyneuropathy (HP:0001271)1.99542652
933-Methylglutaconic aciduria (HP:0003535)1.98420118
94Abnormality of the fingertips (HP:0001211)1.97758345
95Recurrent sinusitis (HP:0011108)1.96304014
96Thrombocytosis (HP:0001894)1.96162052
97Abnormality of the common coagulation pathway (HP:0010990)1.95722720
98B lymphocytopenia (HP:0010976)1.94460124
99Gingival bleeding (HP:0000225)1.92529348
100Attenuation of retinal blood vessels (HP:0007843)1.90849365
101Periodontitis (HP:0000704)1.90844049
102Abnormality of the renal cortex (HP:0011035)1.89808259
103Epistaxis (HP:0000421)1.89500249
104Hyponatremia (HP:0002902)1.87298022
105Arthralgia (HP:0002829)1.87221028
106Abnormal rod and cone electroretinograms (HP:0008323)1.86781274
107Urticaria (HP:0001025)1.85476784
108Bilateral sensorineural hearing impairment (HP:0008619)1.85188202
109Hypochromic anemia (HP:0001931)1.84667449
110Frequent falls (HP:0002359)1.84029092
111Chronic sinusitis (HP:0011109)1.82353414
112Abnormality of transition element cation homeostasis (HP:0011030)1.81432102
113Pulmonary fibrosis (HP:0002206)1.80881793
114Sepsis (HP:0100806)1.79890052
115Microcytic anemia (HP:0001935)1.76350581
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73136685
117Vertigo (HP:0002321)1.69150872
118Pancreatic cysts (HP:0001737)1.66948306
119Alveolar cell carcinoma (HP:0006519)1.66510738
120Recurrent otitis media (HP:0000403)1.65777048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.41932434
2MAP4K13.88349422
3JAK13.73311228
4MAP3K143.44170586
5ITK3.40052778
6CSK2.83617460
7JAK32.78677445
8IKBKE2.67145110
9TYK22.66188362
10TBK12.54856999
11ZAP702.31573664
12IRAK42.27343250
13TAOK32.25101942
14MST42.17080808
15BLK2.11060873
16GRK72.05850179
17NEK91.96925905
18KDR1.85913969
19STK101.84301786
20LCK1.70209618
21IKBKB1.70063896
22NLK1.54707653
23TESK21.51890682
24FGFR41.49594947
25ZAK1.41974589
26SYK1.37803465
27ADRBK21.37793937
28BTK1.34619442
29IRAK31.33535101
30FRK1.32057552
31PRKCQ1.31521824
32CLK11.31248666
33NUAK11.29829525
34TEC1.29246270
35MAP3K131.26652573
36GRK61.26555716
37MAP2K61.22715076
38VRK11.22554305
39FGFR31.22406843
40PIM11.22373545
41PASK1.21329074
42FES1.17949794
43EPHB11.16705938
44HCK1.12229210
45MAP4K21.10972078
46TYRO31.10645154
47CAMKK21.05536925
48CHUK1.03972251
49MUSK1.03834511
50KIT1.02766739
51MAP3K121.02622399
52BCKDK1.00893390
53SIK20.97656677
54LYN0.96746914
55TRPM70.96476357
56NME20.85921391
57MAP3K110.83503260
58PIK3CG0.81855621
59IRAK10.80657098
60STK240.79833535
61EPHA30.78518108
62SIK30.77380046
63JAK20.74801390
64CAMKK10.72722784
65PIK3CA0.71295349
66RPS6KA40.70165186
67TESK10.67705336
68GRK10.67035559
69TNK20.64836884
70STK40.61094342
71LIMK10.57532059
72MARK30.53057038
73FGR0.51795728
74TSSK60.50686953
75INSR0.50592386
76LRRK20.49989009
77IGF1R0.48085618
78ACVR1B0.46351482
79MAP3K100.46220016
80FYN0.46131788
81PIM20.45020142
82BMPR20.44440663
83MELK0.44408480
84PRKCH0.43791607
85MAPK130.42975812
86CDK40.42493777
87CDK90.40850487
88IRAK20.40619255
89RIPK40.40065668
90MAPKAPK30.39054431
91BMX0.38768267
92OXSR10.38297748
93ABL10.37943579
94PRKCD0.37417041
95HIPK20.37296180
96TGFBR20.35844416
97PRKD20.35641071
98ADRBK10.35214644
99TLK10.33348381
100RIPK10.33151236
101TTN0.32277289
102PTK2B0.31465440
103CSF1R0.31099250
104DMPK0.30002598
105GSK3A0.29281527
106PRPF4B0.28688945
107BRD40.28489840
108MAPKAPK20.28353756
109ERBB30.28034260
110CSNK1A1L0.27405577
111EIF2AK20.26733061
112DAPK30.26423729
113CSNK1A10.26163560
114MAP3K80.25786181
115MAPK110.25162221
116PDK10.24080956
117RPS6KA50.23962392
118STK110.23719106
119WNK40.22345708
120EGFR0.22318525
121PAK30.21894621
122BCR0.21515979
123INSRR0.19729688
124CDK190.19720174
125MATK0.19346061
126NEK60.19227221
127SRC0.18536129
128MAP3K50.17142667
129CDC42BPA0.16574707
130SIK10.16185062
131MAPK30.13525734
132RAF10.13128255
133PDGFRB0.13104156
134PKN10.12789507

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053327.19967415
2Allograft rejection_Homo sapiens_hsa053304.45649177
3Primary immunodeficiency_Homo sapiens_hsa053404.15448999
4* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046504.03241027
5Antigen processing and presentation_Homo sapiens_hsa046123.71740377
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.32143834
7Autoimmune thyroid disease_Homo sapiens_hsa053203.17840012
8Type I diabetes mellitus_Homo sapiens_hsa049402.72744831
9Viral myocarditis_Homo sapiens_hsa054162.44568340
10Measles_Homo sapiens_hsa051622.39835188
11T cell receptor signaling pathway_Homo sapiens_hsa046602.35023421
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.22840430
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.92402512
14Leishmaniasis_Homo sapiens_hsa051401.90309648
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73685198
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.64441178
17Osteoclast differentiation_Homo sapiens_hsa043801.63612630
18Hematopoietic cell lineage_Homo sapiens_hsa046401.50963850
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47487244
20Chemokine signaling pathway_Homo sapiens_hsa040621.46243692
21B cell receptor signaling pathway_Homo sapiens_hsa046621.45043828
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32882132
23Toxoplasmosis_Homo sapiens_hsa051451.32304980
24Apoptosis_Homo sapiens_hsa042101.31637408
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26115727
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23510422
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22365359
28Herpes simplex infection_Homo sapiens_hsa051681.17340143
29TNF signaling pathway_Homo sapiens_hsa046681.16996857
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.16138498
31Influenza A_Homo sapiens_hsa051641.11430630
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09774687
33Staphylococcus aureus infection_Homo sapiens_hsa051501.07453822
34Phototransduction_Homo sapiens_hsa047441.06221101
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05007337
36Nitrogen metabolism_Homo sapiens_hsa009101.04650490
37Shigellosis_Homo sapiens_hsa051311.04217431
38Pertussis_Homo sapiens_hsa051330.96025814
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94928643
40Rheumatoid arthritis_Homo sapiens_hsa053230.89506429
41Hepatitis B_Homo sapiens_hsa051610.87147760
42Legionellosis_Homo sapiens_hsa051340.84708912
43Tuberculosis_Homo sapiens_hsa051520.84174923
44Linoleic acid metabolism_Homo sapiens_hsa005910.84101076
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83777944
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83108507
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81914980
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79473054
49Oxidative phosphorylation_Homo sapiens_hsa001900.77705569
50* Malaria_Homo sapiens_hsa051440.71600069
51Salmonella infection_Homo sapiens_hsa051320.71260678
52HTLV-I infection_Homo sapiens_hsa051660.70317776
53Caffeine metabolism_Homo sapiens_hsa002320.68515218
54Asthma_Homo sapiens_hsa053100.67164733
55Acute myeloid leukemia_Homo sapiens_hsa052210.66322521
56Pancreatic cancer_Homo sapiens_hsa052120.65818085
57Other glycan degradation_Homo sapiens_hsa005110.64854008
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63960397
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60867094
60VEGF signaling pathway_Homo sapiens_hsa043700.59814755
61Olfactory transduction_Homo sapiens_hsa047400.59534109
62Hepatitis C_Homo sapiens_hsa051600.58593179
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56778053
64Platelet activation_Homo sapiens_hsa046110.56081482
65Epstein-Barr virus infection_Homo sapiens_hsa051690.55907384
66Colorectal cancer_Homo sapiens_hsa052100.54850519
67Parkinsons disease_Homo sapiens_hsa050120.53081507
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50399444
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48938248
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47632344
71Prolactin signaling pathway_Homo sapiens_hsa049170.46534952
72Regulation of autophagy_Homo sapiens_hsa041400.46076709
73ABC transporters_Homo sapiens_hsa020100.45440666
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45153919
75Lysosome_Homo sapiens_hsa041420.43357357
76Viral carcinogenesis_Homo sapiens_hsa052030.42238547
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42006498
78p53 signaling pathway_Homo sapiens_hsa041150.40153718
79Endocytosis_Homo sapiens_hsa041440.37267732
80Morphine addiction_Homo sapiens_hsa050320.36853004
81Chronic myeloid leukemia_Homo sapiens_hsa052200.35989405
82RNA degradation_Homo sapiens_hsa030180.35814067
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35376059
84African trypanosomiasis_Homo sapiens_hsa051430.35367246
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.31087768
86RNA polymerase_Homo sapiens_hsa030200.30840011
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29980464
88Alzheimers disease_Homo sapiens_hsa050100.29874197
89Adherens junction_Homo sapiens_hsa045200.29010067
90Proteasome_Homo sapiens_hsa030500.27888864
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26234189
92Non-small cell lung cancer_Homo sapiens_hsa052230.25833669
93Ether lipid metabolism_Homo sapiens_hsa005650.24436175
94Small cell lung cancer_Homo sapiens_hsa052220.23808286
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.23772396
96Taste transduction_Homo sapiens_hsa047420.22412255
97FoxO signaling pathway_Homo sapiens_hsa040680.21460832
98Systemic lupus erythematosus_Homo sapiens_hsa053220.20980252
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20452102
100cAMP signaling pathway_Homo sapiens_hsa040240.18734717
101Arachidonic acid metabolism_Homo sapiens_hsa005900.18514167
102Basal transcription factors_Homo sapiens_hsa030220.18400253
103Homologous recombination_Homo sapiens_hsa034400.17906202
104Glycerolipid metabolism_Homo sapiens_hsa005610.16854143
105Dorso-ventral axis formation_Homo sapiens_hsa043200.15756002
106Peroxisome_Homo sapiens_hsa041460.15166368
107Amoebiasis_Homo sapiens_hsa051460.14964700
108Prion diseases_Homo sapiens_hsa050200.14691947
109Focal adhesion_Homo sapiens_hsa045100.13800279
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13731402
111MAPK signaling pathway_Homo sapiens_hsa040100.13070305
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.12332916
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.12262489
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12156284
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11407737
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.10862043
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10728399
118Retinol metabolism_Homo sapiens_hsa008300.10412918
119Salivary secretion_Homo sapiens_hsa049700.10181595
120Rap1 signaling pathway_Homo sapiens_hsa040150.09981024
121Fanconi anemia pathway_Homo sapiens_hsa034600.09110930
122Amphetamine addiction_Homo sapiens_hsa050310.08640490
123Phagosome_Homo sapiens_hsa041450.05554450
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.04308721
125Renal cell carcinoma_Homo sapiens_hsa052110.03279357
126Notch signaling pathway_Homo sapiens_hsa043300.02408155
127Pathways in cancer_Homo sapiens_hsa052000.02353794
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.00794727
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.00675420
130Ras signaling pathway_Homo sapiens_hsa040140.00176569
131Insulin resistance_Homo sapiens_hsa04931-0.0559164
132Type II diabetes mellitus_Homo sapiens_hsa04930-0.0458979
133Ribosome_Homo sapiens_hsa03010-0.0366321
134Choline metabolism in cancer_Homo sapiens_hsa05231-0.0314709
135Prostate cancer_Homo sapiens_hsa05215-0.0284723
136PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0188069
137Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0161905
138Endometrial cancer_Homo sapiens_hsa05213-0.0092252
139Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0059660

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