KMO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61777089
2L-phenylalanine catabolic process (GO:0006559)7.61777089
3L-phenylalanine metabolic process (GO:0006558)7.24473485
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24473485
5* aromatic amino acid family catabolic process (GO:0009074)7.11367166
6* indole-containing compound catabolic process (GO:0042436)6.59279843
7* indolalkylamine catabolic process (GO:0046218)6.59279843
8* tryptophan catabolic process (GO:0006569)6.59279843
9* kynurenine metabolic process (GO:0070189)6.31675687
10* tryptophan metabolic process (GO:0006568)6.13690034
11bile acid biosynthetic process (GO:0006699)6.11963541
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.10021578
13glyoxylate metabolic process (GO:0046487)5.93515457
14urea cycle (GO:0000050)5.70359394
15urea metabolic process (GO:0019627)5.70359394
16alpha-linolenic acid metabolic process (GO:0036109)5.62811430
17regulation of vitamin D biosynthetic process (GO:0060556)5.53162603
18complement activation, alternative pathway (GO:0006957)5.48160426
19negative regulation of fibrinolysis (GO:0051918)5.45560560
20cysteine metabolic process (GO:0006534)5.39801418
21regulation of protein activation cascade (GO:2000257)5.39325844
22high-density lipoprotein particle remodeling (GO:0034375)5.36120163
23regulation of fibrinolysis (GO:0051917)5.28663953
24protein carboxylation (GO:0018214)5.28071591
25peptidyl-glutamic acid carboxylation (GO:0017187)5.28071591
26sulfur amino acid catabolic process (GO:0000098)5.27908633
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.25279827
28nitrogen cycle metabolic process (GO:0071941)5.24365708
29serine family amino acid catabolic process (GO:0009071)5.15469049
30bile acid metabolic process (GO:0008206)5.14884413
31positive regulation of heat generation (GO:0031652)5.11490454
32* aromatic amino acid family metabolic process (GO:0009072)5.05914621
33regulation of complement activation (GO:0030449)5.04778606
34negative regulation of interleukin-12 production (GO:0032695)4.96656506
35homocysteine metabolic process (GO:0050667)4.92937851
36regulation of fever generation (GO:0031620)4.82537830
37tyrosine metabolic process (GO:0006570)4.80411097
38lysine metabolic process (GO:0006553)4.79590231
39lysine catabolic process (GO:0006554)4.79590231
40regulation of triglyceride catabolic process (GO:0010896)4.75347275
41* alpha-amino acid catabolic process (GO:1901606)4.70671933
42amino-acid betaine metabolic process (GO:0006577)4.68007989
43reverse cholesterol transport (GO:0043691)4.66657566
44regulation of cholesterol esterification (GO:0010872)4.65414101
45response to peptidoglycan (GO:0032494)4.64127004
46regulation of cytokine secretion involved in immune response (GO:0002739)4.61519242
47plasma lipoprotein particle remodeling (GO:0034369)4.61373328
48protein-lipid complex remodeling (GO:0034368)4.61373328
49macromolecular complex remodeling (GO:0034367)4.61373328
50triglyceride homeostasis (GO:0070328)4.53428255
51acylglycerol homeostasis (GO:0055090)4.53428255
52* indolalkylamine metabolic process (GO:0006586)4.52287057
53negative regulation of sterol transport (GO:0032372)4.51378680
54negative regulation of cholesterol transport (GO:0032375)4.51378680
55coenzyme catabolic process (GO:0009109)4.47416302
56cellular ketone body metabolic process (GO:0046950)4.46313989
57* amine catabolic process (GO:0009310)4.46204815
58* cellular biogenic amine catabolic process (GO:0042402)4.46204815
59phospholipid efflux (GO:0033700)4.43677098
60bile acid and bile salt transport (GO:0015721)4.42469165
61glycine metabolic process (GO:0006544)4.40256941
62lipopolysaccharide-mediated signaling pathway (GO:0031663)4.35965032
63regulation of chronic inflammatory response (GO:0002676)4.34782837
64positive regulation of chemokine biosynthetic process (GO:0045080)4.34689353
65regulation of vitamin metabolic process (GO:0030656)4.33519000
66cellular glucuronidation (GO:0052695)4.32205090
67* cellular amino acid catabolic process (GO:0009063)4.32045135
68imidazole-containing compound metabolic process (GO:0052803)4.29903161
69glutamate metabolic process (GO:0006536)4.24949125
70serine family amino acid metabolic process (GO:0009069)4.24839467
71ethanol oxidation (GO:0006069)4.21024196
72plasma lipoprotein particle clearance (GO:0034381)4.19943308
73* benzene-containing compound metabolic process (GO:0042537)4.18485685
74regulation of T-helper 1 cell differentiation (GO:0045625)4.15985770
75regulation of chemokine biosynthetic process (GO:0045073)4.14695827
76cellular modified amino acid catabolic process (GO:0042219)4.13769317
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.12875300
78regulation of mononuclear cell migration (GO:0071675)4.10820992
79cholesterol efflux (GO:0033344)4.07946650
80regulation of interferon-alpha production (GO:0032647)4.04670340
81serine family amino acid biosynthetic process (GO:0009070)4.03773981
82aldehyde catabolic process (GO:0046185)4.00790467
83drug catabolic process (GO:0042737)3.96682319
84arginine metabolic process (GO:0006525)3.96438797
85regulation of heat generation (GO:0031650)3.95615630
86complement activation, classical pathway (GO:0006958)3.94862606
87fibrinolysis (GO:0042730)3.93088164
88regulation of podosome assembly (GO:0071801)3.92174930
89low-density lipoprotein particle remodeling (GO:0034374)3.90872691
90macrophage activation involved in immune response (GO:0002281)3.89308232
91complement activation (GO:0006956)3.87142639
92* dicarboxylic acid biosynthetic process (GO:0043650)3.86586016
93uronic acid metabolic process (GO:0006063)3.85807967
94glucuronate metabolic process (GO:0019585)3.85807967
95ketone body metabolic process (GO:1902224)3.85456170
96plasma lipoprotein particle assembly (GO:0034377)3.84291959
97acetyl-CoA metabolic process (GO:0006084)3.82005175
98cofactor catabolic process (GO:0051187)3.80050696
99protein activation cascade (GO:0072376)3.79734648
100blood coagulation, intrinsic pathway (GO:0007597)3.79359098
101cytolysis (GO:0019835)3.78717228
102phospholipid homeostasis (GO:0055091)3.78594272
103* organic acid catabolic process (GO:0016054)3.78483036
104* carboxylic acid catabolic process (GO:0046395)3.78483036
105short-chain fatty acid metabolic process (GO:0046459)3.78249464
106neutrophil activation involved in immune response (GO:0002283)3.74384012
107urate metabolic process (GO:0046415)3.72588552
108positive regulation of lipoprotein lipase activity (GO:0051006)3.72564525
109positive regulation of triglyceride lipase activity (GO:0061365)3.72564525
110cellular response to type I interferon (GO:0071357)3.71942427
111type I interferon signaling pathway (GO:0060337)3.71942427
112immunoglobulin mediated immune response (GO:0016064)3.71108337
113positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.70570654
114response to type I interferon (GO:0034340)3.67354195
115very-low-density lipoprotein particle assembly (GO:0034379)3.66660357
116negative regulation of lipase activity (GO:0060192)3.66582006
117regulation of bile acid biosynthetic process (GO:0070857)3.66577101
118cholesterol homeostasis (GO:0042632)3.66537631
119drug transmembrane transport (GO:0006855)3.64748063
120positive regulation of lipid catabolic process (GO:0050996)3.62983552
121negative regulation of cytokine production involved in immune response (GO:0002719)3.62827557
122sterol homeostasis (GO:0055092)3.60534245
123T-helper 1 type immune response (GO:0042088)3.55140588
124regulation of cholesterol homeostasis (GO:2000188)3.54954667
125exogenous drug catabolic process (GO:0042738)3.54411828
126* NAD biosynthetic process (GO:0009435)3.54127971
127response to protozoan (GO:0001562)3.48984592
128negative regulation of nitric oxide biosynthetic process (GO:0045019)3.47896454
129glycosphingolipid catabolic process (GO:0046479)3.47778622
130branching involved in labyrinthine layer morphogenesis (GO:0060670)3.46312195
131interferon-gamma-mediated signaling pathway (GO:0060333)3.43186589
132defense response to protozoan (GO:0042832)3.40415189
133positive regulation of NF-kappaB import into nucleus (GO:0042346)3.39648227
134monocyte chemotaxis (GO:0002548)3.38301677
135positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37968811
136positive regulation of gamma-delta T cell activation (GO:0046645)3.36022450
137oligosaccharide catabolic process (GO:0009313)3.32986350
138positive regulation of interferon-alpha production (GO:0032727)3.31408426
139regulation of membrane protein ectodomain proteolysis (GO:0051043)3.30132269
140positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.29082244
141regulation of immunoglobulin secretion (GO:0051023)3.28622179
142positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.28081658
143regulation of nitric oxide biosynthetic process (GO:0045428)3.26166085
144myeloid dendritic cell differentiation (GO:0043011)3.24340321
145positive regulation of nitric oxide biosynthetic process (GO:0045429)3.24309022
146regulation of interleukin-8 biosynthetic process (GO:0045414)3.21617932
147positive regulation of acute inflammatory response (GO:0002675)3.21284828
148germinal center formation (GO:0002467)3.13711050
149negative regulation of myeloid cell apoptotic process (GO:0033033)3.13116267
150cellular response to lipopolysaccharide (GO:0071222)3.11278967
151negative regulation of growth of symbiont in host (GO:0044130)3.10770523
152negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.10770523
153modulation of growth of symbiont involved in interaction with host (GO:0044144)3.10770523
154regulation of growth of symbiont in host (GO:0044126)3.10770523
155positive regulation of type 2 immune response (GO:0002830)3.10470674
156glycolipid catabolic process (GO:0019377)3.09002421
157granulocyte activation (GO:0036230)3.08460350
158regulation of interferon-beta biosynthetic process (GO:0045357)3.08248027
159NIK/NF-kappaB signaling (GO:0038061)3.06049601
160ceramide catabolic process (GO:0046514)3.05723564
161cellular response to molecule of bacterial origin (GO:0071219)3.03076944
162negative regulation of lipid storage (GO:0010888)3.02175011
163detection of molecule of bacterial origin (GO:0032490)3.02072630
164regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.01153176
165positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.00495044
166positive regulation of interleukin-6 production (GO:0032755)3.00332310
167regulation of interleukin-12 production (GO:0032655)3.00234971
168hydrogen peroxide biosynthetic process (GO:0050665)2.98322638
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.96040663
170regulation of inflammatory response to antigenic stimulus (GO:0002861)2.94554622
171negative regulation of production of molecular mediator of immune response (GO:0002701)2.91996686
172regulation of heterotypic cell-cell adhesion (GO:0034114)2.91703189
173regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.90412177
174negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.89154239
175regulation of NF-kappaB import into nucleus (GO:0042345)2.87061434
176positive regulation of interferon-beta production (GO:0032728)2.87052883
177positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85865070
178positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85139689
179positive regulation by symbiont of host defense response (GO:0052509)2.82441263
180modulation by symbiont of host defense response (GO:0052031)2.82441263
181modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82441263
182modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82441263
183positive regulation by organism of defense response of other organism involved in symbiotic interact2.82441263
184modulation by symbiont of host immune response (GO:0052553)2.82441263
185myeloid dendritic cell activation (GO:0001773)2.81870875
186regulation of T-helper 2 cell differentiation (GO:0045628)2.80660963
187cellular response to nicotine (GO:0071316)2.80539841
188cellular response to interferon-gamma (GO:0071346)2.79940415
189regulation of T-helper cell differentiation (GO:0045622)2.79905194
190positive regulation of T-helper cell differentiation (GO:0045624)2.76493477
191negative regulation of amino acid transport (GO:0051956)2.74986983
192cellular response to thyroid hormone stimulus (GO:0097067)2.74781316
193positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.74355858
194regulation of antigen processing and presentation (GO:0002577)2.73492945
195response to interferon-gamma (GO:0034341)2.68075998
196eosinophil chemotaxis (GO:0048245)2.67719949
197response to muramyl dipeptide (GO:0032495)2.66536151
198B cell mediated immunity (GO:0019724)2.66292414
199cellular response to ethanol (GO:0071361)2.66114352
200myeloid cell activation involved in immune response (GO:0002275)2.65766798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.32759401
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.21386463
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14371226
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.44715327
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21315254
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09816313
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40188149
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.18102408
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.09351628
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04701768
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00614700
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.56871626
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56440476
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.55742330
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51889502
16VDR_24787735_ChIP-Seq_THP-1_Human2.37772569
17* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22406738
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.08278023
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05408457
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03637581
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.01734265
22* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8159699
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.92216727
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.87681530
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87222564
26* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86801017
27SPI1_23127762_ChIP-Seq_K562_Human1.82311601
28* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70422735
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68549750
30SCL_19346495_ChIP-Seq_HPC-7_Human1.67891640
31SPI1_23547873_ChIP-Seq_NB4_Human1.67373933
32HTT_18923047_ChIP-ChIP_STHdh_Human1.64831786
33GATA1_22025678_ChIP-Seq_K562_Human1.64599750
34RUNX_20019798_ChIP-Seq_JUKART_Human1.63521971
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.58211541
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48179346
37VDR_24763502_ChIP-Seq_THP-1_Human1.47661526
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44121985
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.42367485
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40847681
41CLOCK_20551151_ChIP-Seq_293T_Human1.37831911
42* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37503933
43GATA3_26560356_Chip-Seq_TH2_Human1.35712188
44* PU_27001747_Chip-Seq_BMDM_Mouse1.32803982
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32449123
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32366156
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30405434
48* MYB_26560356_Chip-Seq_TH2_Human1.29503260
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28604360
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.28508031
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27819960
52STAT1_20625510_ChIP-Seq_HELA_Human1.22842281
53CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21469909
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18638044
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17564293
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14510788
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12920515
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12739366
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12252486
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06141490
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05797740
62GATA3_27048872_Chip-Seq_THYMUS_Human1.04105146
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.02330771
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95831627
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93965892
66SMRT_27268052_Chip-Seq_Bcells_Human0.92635672
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91682132
68MYB_26560356_Chip-Seq_TH1_Human0.91668238
69GATA1_19941826_ChIP-Seq_K562_Human0.91082515
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90517771
71STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90443173
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90102641
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89461804
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88750088
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88581575
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88425218
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87998617
78MAF_26560356_Chip-Seq_TH1_Human0.87366269
79VDR_21846776_ChIP-Seq_THP-1_Human0.86277846
80KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86002469
81SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85065835
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82036075
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82003466
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80792968
85GATA4_25053715_ChIP-Seq_YYC3_Human0.80549241
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.79495443
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78486963
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76687184
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76185858
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.75254661
91TFEB_21752829_ChIP-Seq_HELA_Human0.74929605
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73934563
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72532987
94* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72074919
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71466620
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.71062158
97* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70896614
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70353193
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69176313
100SOX2_20726797_ChIP-Seq_SW620_Human0.68344711
101CEBPB_22108803_ChIP-Seq_LS180_Human0.67361637
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67266334
103IRF8_27001747_Chip-Seq_BMDM_Mouse0.65485917
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64670089
105GATA1_19941827_ChIP-Seq_MEL86_Mouse0.64200270
106TAF15_26573619_Chip-Seq_HEK293_Human0.63967866
107* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.63571588
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63445946
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.62641530
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61739998
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61739998
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61413802
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60690992
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.60428102
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.58842480
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.58828450
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.57448754
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56858391
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.54405389
120AR_20517297_ChIP-Seq_VCAP_Human0.54307847
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54003301
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.53484264
123EGR1_19032775_ChIP-ChIP_M12_Human0.53351401
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.52464332
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.52342703
126* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51953170
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.51782903
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51612891
129* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.51474377
130STAT1_17558387_ChIP-Seq_HELA_Human0.51062672
131MYC_19915707_ChIP-ChIP_AK7_Human0.50647961
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.50629267
133* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49937820
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49413713
135* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.49381057
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.48597956
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.47628830
138LXR_22292898_ChIP-Seq_THP-1_Human0.47067865
139* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46929013
140* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.46306005
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.46244417
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.46155058
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46063235
144CBP_21632823_ChIP-Seq_H3396_Human0.45322219
145P53_21459846_ChIP-Seq_SAOS-2_Human0.45121730
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.44493941
147IRF8_21731497_ChIP-ChIP_J774_Mouse0.44275302
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43897867
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.42972230
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.42804380
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.42667859
152TAF2_19829295_ChIP-Seq_ESCs_Human0.42514800
153* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42199452
154GATA2_19941826_ChIP-Seq_K562_Human0.42023253
155* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.41610351
156* CRX_20693478_ChIP-Seq_RETINA_Mouse0.41245324
157ZNF263_19887448_ChIP-Seq_K562_Human0.41117482
158CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.39454537
159IRF1_19129219_ChIP-ChIP_H3396_Human0.39402576
160CDX2_22108803_ChIP-Seq_LS180_Human0.39048448
161ESR1_20079471_ChIP-ChIP_T-47D_Human0.38494766
162NFE2_27457419_Chip-Seq_LIVER_Mouse0.37764894
163CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37033203
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36506300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21229131
2MP0005360_urolithiasis7.57490649
3MP0005085_abnormal_gallbladder_physiolo6.33844174
4MP0005365_abnormal_bile_salt6.09901175
5MP0003303_peritoneal_inflammation5.41687680
6MP0008875_abnormal_xenobiotic_pharmacok5.01236207
7MP0003806_abnormal_nucleotide_metabolis4.16193872
8MP0003252_abnormal_bile_duct3.95489402
9MP0010329_abnormal_lipoprotein_level3.46110875
10MP0002148_abnormal_hypersensitivity_rea3.42104278
11MP0009840_abnormal_foam_cell2.99414806
12MP0005083_abnormal_biliary_tract2.84514215
13MP0005332_abnormal_amino_acid2.82605666
14MP0003195_calcinosis2.80136392
15MP0004510_myositis2.74838576
16MP0005000_abnormal_immune_tolerance2.59123649
17MP0005671_abnormal_response_to2.58119708
18MP0001666_abnormal_nutrient_absorption2.57281556
19MP0004019_abnormal_vitamin_homeostasis2.33326670
20MP0002138_abnormal_hepatobiliary_system2.24504404
21MP0003191_abnormal_cellular_cholesterol2.19513611
22MP0000609_abnormal_liver_physiology2.13853391
23MP0005167_abnormal_blood-brain_barrier2.11463106
24MP0002452_abnormal_antigen_presenting2.07957392
25MP0003300_gastrointestinal_ulcer2.03943002
26MP0002723_abnormal_immune_serum2.03890088
27MP0002118_abnormal_lipid_homeostasis2.03784269
28MP0001533_abnormal_skeleton_physiology1.94684183
29MP0003868_abnormal_feces_composition1.89950972
30MP0000343_altered_response_to1.89863443
31MP0003172_abnormal_lysosome_physiology1.89739967
32MP0006054_spinal_hemorrhage1.85481903
33MP0008004_abnormal_stomach_pH1.83981565
34MP0005319_abnormal_enzyme/_coenzyme1.80882171
35MP0009278_abnormal_bone_marrow1.76445352
36MP0001764_abnormal_homeostasis1.69385847
37MP0010155_abnormal_intestine_physiology1.68558372
38MP0009697_abnormal_copulation1.68417175
39MP0002332_abnormal_exercise_endurance1.67307927
40MP0001545_abnormal_hematopoietic_system1.66068543
41MP0005397_hematopoietic_system_phenotyp1.66068543
42MP0003011_delayed_dark_adaptation1.66043819
43MP0004947_skin_inflammation1.65213966
44MP0005584_abnormal_enzyme/coenzyme_acti1.60517265
45MP0001819_abnormal_immune_cell1.59981773
46MP0002420_abnormal_adaptive_immunity1.59398123
47MP0000685_abnormal_immune_system1.57339139
48MP0005451_abnormal_body_composition1.56578517
49MP0005310_abnormal_salivary_gland1.55211688
50MP0002405_respiratory_system_inflammati1.40562884
51MP0009643_abnormal_urine_homeostasis1.35879406
52MP0003448_altered_tumor_morphology1.33200044
53MP0002998_abnormal_bone_remodeling1.31730421
54MP0003453_abnormal_keratinocyte_physiol1.30856251
55MP0003186_abnormal_redox_activity1.28444961
56MP0009764_decreased_sensitivity_to1.18995856
57MP0009333_abnormal_splenocyte_physiolog1.17926325
58MP0000598_abnormal_liver_morphology1.17798705
59MP0001501_abnormal_sleep_pattern1.13628001
60MP0000716_abnormal_immune_system1.12769007
61MP0003656_abnormal_erythrocyte_physiolo1.11469950
62MP0005647_abnormal_sex_gland1.10833802
63MP0000858_altered_metastatic_potential1.08509475
64MP0008469_abnormal_protein_level1.03631110
65MP0005164_abnormal_response_to1.03454859
66MP0009763_increased_sensitivity_to1.02474934
67MP0002876_abnormal_thyroid_physiology1.01641088
68MP0005636_abnormal_mineral_homeostasis0.98916937
69MP0005408_hypopigmentation0.97935994
70MP0000604_amyloidosis0.97075187
71MP0005084_abnormal_gallbladder_morpholo0.96959378
72MP0002254_reproductive_system_inflammat0.93208516
73MP0003646_muscle_fatigue0.91352390
74MP0009642_abnormal_blood_homeostasis0.90531959
75MP0002398_abnormal_bone_marrow0.86699462
76MP0005670_abnormal_white_adipose0.86309557
77MP0003705_abnormal_hypodermis_morpholog0.85449671
78MP0000689_abnormal_spleen_morphology0.84649122
79MP0001663_abnormal_digestive_system0.84416209
80MP0000920_abnormal_myelination0.82843396
81MP0003183_abnormal_peptide_metabolism0.81591049
82MP0006036_abnormal_mitochondrial_physio0.80932441
83MP0005376_homeostasis/metabolism_phenot0.80149224
84MP0002429_abnormal_blood_cell0.79756945
85MP0009765_abnormal_xenobiotic_induced0.79609995
86MP0010368_abnormal_lymphatic_system0.76431861
87MP0005220_abnormal_exocrine_pancreas0.74378940
88MP0005165_increased_susceptibility_to0.74251010
89MP0002078_abnormal_glucose_homeostasis0.74245740
90MP0005390_skeleton_phenotype0.74113895
91MP0005535_abnormal_body_temperature0.69476058
92MP0002277_abnormal_respiratory_mucosa0.69415028
93MP0001542_abnormal_bone_strength0.68434216
94MP0005464_abnormal_platelet_physiology0.68132133
95MP0003436_decreased_susceptibility_to0.67563212
96MP0002722_abnormal_immune_system0.67201972
97MP0005334_abnormal_fat_pad0.66428004
98MP0002837_dystrophic_cardiac_calcinosis0.66319156
99MP0001756_abnormal_urination0.65240601
100MP0001661_extended_life_span0.64589000
101MP0003690_abnormal_glial_cell0.63692101
102MP0001835_abnormal_antigen_presentation0.63572192
103MP0002928_abnormal_bile_duct0.63322080
104MP0002971_abnormal_brown_adipose0.63036809
105MP0005266_abnormal_metabolism0.62692362
106MP0000371_diluted_coat_color0.62113771
107MP0002136_abnormal_kidney_physiology0.60903391
108MP0004381_abnormal_hair_follicle0.59014305
109MP0003763_abnormal_thymus_physiology0.58085822
110MP0004130_abnormal_muscle_cell0.57749523
111MP0003724_increased_susceptibility_to0.55113015
112MP0001853_heart_inflammation0.54959949
113MP0010307_abnormal_tumor_latency0.54629902
114MP0003633_abnormal_nervous_system0.53913406
115MP0004808_abnormal_hematopoietic_stem0.52656815
116MP0002693_abnormal_pancreas_physiology0.51509729
117MP0000639_abnormal_adrenal_gland0.50648030
118MP0006035_abnormal_mitochondrial_morpho0.50305302
119MP0003795_abnormal_bone_structure0.50275793
120MP0009053_abnormal_anal_canal0.49232023
121MP0001845_abnormal_inflammatory_respons0.48834182
122MP0003638_abnormal_response/metabolism_0.48545105
123MP0005448_abnormal_energy_balance0.46696299
124MP0005395_other_phenotype0.46492098
125MP0003329_amyloid_beta_deposits0.46347527
126MP0004782_abnormal_surfactant_physiolog0.45700200
127MP0008873_increased_physiological_sensi0.43390376
128MP0005166_decreased_susceptibility_to0.42854029
129MP0008874_decreased_physiological_sensi0.42675724
130MP0006082_CNS_inflammation0.41051488
131MP0005075_abnormal_melanosome_morpholog0.40670175
132MP0003953_abnormal_hormone_level0.36949719
133MP0009785_altered_susceptibility_to0.36885012
134MP0002419_abnormal_innate_immunity0.36593752
135MP0003718_maternal_effect0.36186815
136MP0001790_abnormal_immune_system0.36169177
137MP0005387_immune_system_phenotype0.36169177
138MP0005025_abnormal_response_to0.35516801
139MP0005058_abnormal_lysosome_morphology0.35281301
140MP0002168_other_aberrant_phenotype0.34851677
141MP0000249_abnormal_blood_vessel0.34410657
142MP0003075_altered_response_to0.34306483
143MP0009672_abnormal_birth_weight0.34095009
144MP0004883_abnormal_blood_vessel0.33303119
145MP0000230_abnormal_systemic_arterial0.32593604
146MP0002822_catalepsy0.32589657
147MP0000427_abnormal_hair_cycle0.32052576
148MP0005666_abnormal_adipose_tissue0.31712316
149MP0000579_abnormal_nail_morphology0.31589600
150MP0001881_abnormal_mammary_gland0.30743307
151MP0002132_abnormal_respiratory_system0.30716647
152MP0001800_abnormal_humoral_immune0.30546647
153MP0009115_abnormal_fat_cell0.29927613

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.18325473
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.16354869
3Deep venous thrombosis (HP:0002625)7.11122930
4Abnormality of glycolipid metabolism (HP:0010969)6.92407129
5Abnormality of liposaccharide metabolism (HP:0010968)6.92407129
6Abnormality of glycosphingolipid metabolism (HP:0004343)6.92407129
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51424093
8Prolonged partial thromboplastin time (HP:0003645)6.45174321
9Hypobetalipoproteinemia (HP:0003563)6.23560106
10Xanthomatosis (HP:0000991)6.06181575
11Complement deficiency (HP:0004431)5.40272625
12Hyperlipoproteinemia (HP:0010980)5.25860164
13Vacuolated lymphocytes (HP:0001922)5.06592900
14Joint hemorrhage (HP:0005261)4.85538158
15Optic neuritis (HP:0100653)4.76331444
16Retrobulbar optic neuritis (HP:0100654)4.76331444
17Increased cerebral lipofuscin (HP:0011813)4.66625118
18Abnormality of macrophages (HP:0004311)4.59661906
19Hypolipoproteinemia (HP:0010981)4.56206031
20Orchitis (HP:0100796)4.56187652
21Hyperammonemia (HP:0001987)4.54568762
22Epidermoid cyst (HP:0200040)4.52348943
23Disinhibition (HP:0000734)4.51242075
24Stomatitis (HP:0010280)4.46731786
25Hyperglycinemia (HP:0002154)4.39401272
26Recurrent bacterial skin infections (HP:0005406)4.37621373
27Abnormality of the common coagulation pathway (HP:0010990)4.35064511
28Abnormality of glutamine family amino acid metabolism (HP:0010902)4.29207691
29Ketosis (HP:0001946)4.28305316
30Dysostosis multiplex (HP:0000943)4.27089743
31Abnormality of sulfur amino acid metabolism (HP:0004339)4.24060613
32Abnormality of methionine metabolism (HP:0010901)4.24040950
33Abnormality of aspartate family amino acid metabolism (HP:0010899)4.21917300
34Loss of speech (HP:0002371)4.17588658
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17391435
36Fat malabsorption (HP:0002630)4.13494164
37Hyperglycinuria (HP:0003108)4.06557570
38Recurrent abscess formation (HP:0002722)4.01562074
39Abnormality of pyrimidine metabolism (HP:0004353)3.99897224
40Abnormality of glycine metabolism (HP:0010895)3.99772583
41Abnormality of serine family amino acid metabolism (HP:0010894)3.99772583
42Abnormality of complement system (HP:0005339)3.98148614
43Myositis (HP:0100614)3.98118687
44Hypoalphalipoproteinemia (HP:0003233)3.88992761
45Increased neuronal autofluorescent lipopigment (HP:0002074)3.86575195
46Autoimmune thrombocytopenia (HP:0001973)3.82568779
47Mutism (HP:0002300)3.75766882
48Conjugated hyperbilirubinemia (HP:0002908)3.69165713
49Hypoglycemic coma (HP:0001325)3.66767697
50Abnormality of the intrinsic pathway (HP:0010989)3.60815172
51Mediastinal lymphadenopathy (HP:0100721)3.45517931
52Abnormality of nucleobase metabolism (HP:0010932)3.44164607
53Eczematoid dermatitis (HP:0000976)3.43536427
54Hypercholesterolemia (HP:0003124)3.43010923
55Abnormality of mucopolysaccharide metabolism (HP:0011020)3.38257173
56Abnormality of polysaccharide metabolism (HP:0011012)3.38257173
57Abnormality of glycosaminoglycan metabolism (HP:0004371)3.38257173
58Abnormality of fatty-acid metabolism (HP:0004359)3.35089308
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25948525
60Hyperbilirubinemia (HP:0002904)3.25303613
61Keratoconjunctivitis sicca (HP:0001097)3.23856265
62Urinary glycosaminoglycan excretion (HP:0003541)3.18656366
63Mucopolysacchariduria (HP:0008155)3.18656366
64Steatorrhea (HP:0002570)3.17471193
65Abnormality of purine metabolism (HP:0004352)3.16298299
66Delayed CNS myelination (HP:0002188)3.15830702
67Ketoacidosis (HP:0001993)3.07505536
68Keratoconjunctivitis (HP:0001096)3.05450768
69Abnormality of serum amino acid levels (HP:0003112)3.03913224
70Myocardial infarction (HP:0001658)3.03260117
71Nuclear cataract (HP:0100018)3.00881948
72Increased serum ferritin (HP:0003281)2.95820176
73Hypochromic microcytic anemia (HP:0004840)2.95532586
74Hepatocellular carcinoma (HP:0001402)2.91902810
75Systemic lupus erythematosus (HP:0002725)2.89497664
76Spontaneous abortion (HP:0005268)2.89116129
77Gangrene (HP:0100758)2.87286494
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.86401844
79Neurofibrillary tangles (HP:0002185)2.84248991
80Hematochezia (HP:0002573)2.78775215
81Pulmonary infiltrates (HP:0002113)2.74432894
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.72186293
83Metabolic acidosis (HP:0001942)2.72133048
84Recurrent gram-negative bacterial infections (HP:0005420)2.71630750
85Elevated erythrocyte sedimentation rate (HP:0003565)2.69995963
86Vasculitis (HP:0002633)2.69956528
87Apathy (HP:0000741)2.69615921
88Inappropriate behavior (HP:0000719)2.68382767
89Gout (HP:0001997)2.64970648
90Nausea (HP:0002018)2.64304623
91Skin nodule (HP:0200036)2.62831671
92Vascular calcification (HP:0004934)2.61184875
93Diminished motivation (HP:0000745)2.59704802
94Lethargy (HP:0001254)2.59406118
95Mitral stenosis (HP:0001718)2.57983852
96Purpura (HP:0000979)2.57747507
97Axonal loss (HP:0003447)2.56745668
98Spastic diplegia (HP:0001264)2.55993629
99Parakeratosis (HP:0001036)2.55640937
100Dicarboxylic aciduria (HP:0003215)2.54726656
101Abnormality of dicarboxylic acid metabolism (HP:0010995)2.54726656
102Alkalosis (HP:0001948)2.50686358
103Hemoptysis (HP:0002105)2.48428143
104Acanthocytosis (HP:0001927)2.48399893
105Hypoglycemic seizures (HP:0002173)2.43333013
106Obstructive lung disease (HP:0006536)2.43076536
107Chronic obstructive pulmonary disease (HP:0006510)2.43076536
108Polyneuropathy (HP:0001271)2.42262728
109Agnosia (HP:0010524)2.42168767
110Hyperuricemia (HP:0002149)2.41523099
111Increased purine levels (HP:0004368)2.41523099
112Upper motor neuron abnormality (HP:0002127)2.41211257
113Glomerulonephritis (HP:0000099)2.40672767
114Cerebral edema (HP:0002181)2.38705048
115Progressive neurologic deterioration (HP:0002344)2.37915397
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37856591
117Gingival bleeding (HP:0000225)2.33107616
118Recurrent skin infections (HP:0001581)2.32905390
119Neonatal onset (HP:0003623)2.32772329
120Irritability (HP:0000737)2.30956531
121Metaphyseal irregularity (HP:0003025)2.30649259
122Cardiovascular calcification (HP:0011915)2.28999759
123Amyloidosis (HP:0011034)2.27219836
124Abnormal gallbladder morphology (HP:0012437)2.26633964
125Basal ganglia calcification (HP:0002135)2.26583761
126Petechiae (HP:0000967)2.25066123
127Increased IgM level (HP:0003496)2.24950454
128Pulmonary embolism (HP:0002204)2.19990187
129Cholelithiasis (HP:0001081)2.19326419
130Pancreatitis (HP:0001733)2.18958210
131Arterial thrombosis (HP:0004420)2.18610895
132Meningitis (HP:0001287)2.17632004
133Anorexia (HP:0002039)2.16777459
134Malnutrition (HP:0004395)2.16701625
135Sensorimotor neuropathy (HP:0007141)2.15261692
136Thrombophlebitis (HP:0004418)2.14452931
137Generalized aminoaciduria (HP:0002909)2.13481275
138Enlarged kidneys (HP:0000105)2.12638131
139Vertigo (HP:0002321)2.09017751
140Recurrent fungal infections (HP:0002841)2.08592349
141Recurrent viral infections (HP:0004429)2.08432285
142Hepatosplenomegaly (HP:0001433)2.07939470
143Vomiting (HP:0002013)2.07004558
144Abnormal gallbladder physiology (HP:0012438)2.06446208
145Cholecystitis (HP:0001082)2.06446208
146T lymphocytopenia (HP:0005403)2.05874251
147Menorrhagia (HP:0000132)2.04369718
148Encephalitis (HP:0002383)2.03756618
149Esophageal varix (HP:0002040)2.02564098
150Joint swelling (HP:0001386)2.01803286
151Prolonged neonatal jaundice (HP:0006579)2.01280483
152Abnormality of the pleura (HP:0002103)2.00140252
153Late onset (HP:0003584)1.99834924
154Renal cortical cysts (HP:0000803)1.99068068
155Neuronal loss in central nervous system (HP:0002529)1.98756162
156Rickets (HP:0002748)1.98470766
157Hemorrhage of the eye (HP:0011885)1.98460691
158Memory impairment (HP:0002354)1.97794489
159Opisthotonus (HP:0002179)1.97000851
160Abnormality of T cell number (HP:0011839)1.96142313
161Brushfield spots (HP:0001088)1.95415531
162Autoimmune hemolytic anemia (HP:0001890)1.92880395
163Abnormal enzyme/coenzyme activity (HP:0012379)1.91278774
164Elevated hepatic transaminases (HP:0002910)1.90911264
165Abnormality of proline metabolism (HP:0010907)1.90842018
166Hydroxyprolinuria (HP:0003080)1.90842018
167Poikilocytosis (HP:0004447)1.90523136
168Abnormality of iron homeostasis (HP:0011031)1.89244948
169Cerebral inclusion bodies (HP:0100314)1.89167608
170Proximal tubulopathy (HP:0000114)1.89134978
171Dementia (HP:0000726)1.86941758
172Abnormality of transition element cation homeostasis (HP:0011030)1.86394845
173Hypophosphatemic rickets (HP:0004912)1.86281760
174Abnormality of the gallbladder (HP:0005264)1.86075159
175Abnormality of the pericardium (HP:0001697)1.86030299
176Abnormality of B cell number (HP:0010975)1.85584202
177Tetraparesis (HP:0002273)1.85182522
178Recurrent pneumonia (HP:0006532)1.82196427
179Gingivitis (HP:0000230)1.81666927
180Hyperinsulinemic hypoglycemia (HP:0000825)1.80618276
181Urticaria (HP:0001025)1.80134339
182Interstitial pulmonary disease (HP:0006530)1.78055749
183Abnormality of the periventricular white matter (HP:0002518)1.77456866
184Nephritis (HP:0000123)1.73456505
185Glycosuria (HP:0003076)1.72531266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.89125598
2TAOK34.77361633
3FGFR44.24562134
4ERN14.10721695
5SIK13.83205264
6GRK73.58514410
7NME23.26635652
8MATK2.83793131
9DDR22.64991090
10INSRR2.60238405
11RIPK42.59845716
12ERBB42.53864437
13BMPR22.30241927
14TYK22.25603782
15ADRBK22.17069683
16MAP3K142.11208839
17ACVR1B2.06057259
18MAPK112.04784893
19FGR2.02277415
20PIM22.00983745
21TAOK12.00766965
22TXK1.95719063
23MAP2K41.92994347
24TAOK21.78468831
25NEK91.78356679
26PIK3CG1.75824190
27MST1R1.75350104
28FLT31.72576931
29RIPK11.64013251
30IRAK31.60598170
31JAK31.45862545
32MOS1.45666823
33PKN21.42499137
34GRK61.42401530
35TBK11.41088424
36ABL21.31700969
37LATS11.30518347
38MAP4K11.28697345
39MAP2K61.27481808
40JAK11.26433837
41FRK1.17285362
42JAK21.16257657
43MAP2K31.12353766
44CSF1R1.08287407
45PRKAA21.07981356
46PTK61.04076731
47MAP3K71.03874329
48KDR1.02484889
49MAPK41.02281122
50CSK1.02037517
51DAPK21.01384110
52ERBB21.00757620
53PRPF4B0.98240437
54MAP3K100.96289224
55MAP3K130.95482359
56FGFR20.93768490
57EPHA30.93708379
58PINK10.93649015
59STK240.92973073
60CAMKK20.91320608
61TRIB30.91246645
62IKBKE0.90869798
63DYRK30.87402259
64MARK30.86930256
65EPHB10.86702703
66KIT0.82914909
67PRKCZ0.81142425
68STK38L0.80477970
69BLK0.80268716
70MAP3K10.79846190
71LCK0.78210988
72MAP3K50.76284022
73CDC42BPA0.75737411
74CDK60.74548282
75PRKACG0.72130732
76IRAK40.71682515
77PRKCQ0.71596337
78SGK30.70736516
79PDPK10.69965402
80STK100.69075760
81MAPK150.67591092
82HCK0.65463539
83GRK10.64430007
84IRAK10.63093487
85DYRK1B0.62937054
86SGK20.62932804
87TIE10.62559597
88TYRO30.61810380
89PIM10.61670204
90FGFR30.60932914
91MAPK120.60682049
92SIK30.58988229
93PDK10.58431369
94TNK20.57484562
95MAPK70.57129207
96MAP3K30.56448211
97IRAK20.56336032
98PRKAA10.56261103
99CAMK2G0.53492361
100PKN10.53157333
101GSK3A0.52060517
102TEC0.51765536
103PDK20.49580297
104CHUK0.48930543
105BTK0.48786604
106CAMK1D0.48683327
107IKBKB0.48069992
108TGFBR20.46280513
109FES0.45904979
110MST40.43461035
111MAP3K110.42263435
112SYK0.42193044
113ZAP700.41618217
114SGK2230.41368677
115SGK4940.41368677
116MAP3K60.41056545
117ITK0.40044280
118LYN0.39564105
119IGF1R0.36656253
120HIPK20.34021516
121CSNK1G10.33401076
122CDK40.33026097
123EGFR0.32944883
124MET0.32803459
125RPS6KA60.31770389
126ABL10.31120963
127CLK10.30353429
128NUAK10.29851108
129RPS6KC10.29124554
130RPS6KL10.29124554
131INSR0.27911176
132MAPK30.27760890
133CAMK40.25790114
134WNK30.25521856
135PTK20.22550623
136PRKCA0.22081638
137PRKCG0.21893190
138PRKACB0.20976920
139SIK20.19155265
140DAPK30.18343840
141BMX0.18120918
142FYN0.16888401
143TGFBR10.16132967
144PRKCD0.15520873
145EIF2AK20.14522147
146PDGFRB0.12899717
147MAPKAPK20.10976220
148EIF2AK30.10846974

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.64763767
2Nitrogen metabolism_Homo sapiens_hsa009103.46276758
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45675090
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40588973
5Arginine biosynthesis_Homo sapiens_hsa002203.01282246
6Asthma_Homo sapiens_hsa053102.95700439
7Rheumatoid arthritis_Homo sapiens_hsa053232.88628474
8Allograft rejection_Homo sapiens_hsa053302.78857680
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.77717174
10Complement and coagulation cascades_Homo sapiens_hsa046102.76998658
11* Tryptophan metabolism_Homo sapiens_hsa003802.72679293
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64487248
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62083229
14Other glycan degradation_Homo sapiens_hsa005112.56707072
15Graft-versus-host disease_Homo sapiens_hsa053322.56321013
16Leishmaniasis_Homo sapiens_hsa051402.54981052
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53382104
18NF-kappa B signaling pathway_Homo sapiens_hsa040642.52996527
19Fatty acid degradation_Homo sapiens_hsa000712.49278962
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45597744
21Osteoclast differentiation_Homo sapiens_hsa043802.45044935
22NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42763339
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35300879
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29706000
25Malaria_Homo sapiens_hsa051442.20726122
26Peroxisome_Homo sapiens_hsa041462.18564012
27Butanoate metabolism_Homo sapiens_hsa006502.17467745
28Legionellosis_Homo sapiens_hsa051342.15911352
29TNF signaling pathway_Homo sapiens_hsa046682.12449821
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11992346
31Autoimmune thyroid disease_Homo sapiens_hsa053202.09686280
32Type I diabetes mellitus_Homo sapiens_hsa049401.98763504
33Tuberculosis_Homo sapiens_hsa051521.98218792
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.97000192
35Propanoate metabolism_Homo sapiens_hsa006401.96718736
36Histidine metabolism_Homo sapiens_hsa003401.91705767
37Chemical carcinogenesis_Homo sapiens_hsa052041.91597426
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89006513
39PPAR signaling pathway_Homo sapiens_hsa033201.84348502
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.79883982
41Caffeine metabolism_Homo sapiens_hsa002321.79605395
42Fatty acid metabolism_Homo sapiens_hsa012121.77900446
43Staphylococcus aureus infection_Homo sapiens_hsa051501.76903538
44beta-Alanine metabolism_Homo sapiens_hsa004101.76561140
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74975031
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72599352
47Retinol metabolism_Homo sapiens_hsa008301.72507982
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71168611
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70190198
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62649190
51Influenza A_Homo sapiens_hsa051641.58636875
52Phenylalanine metabolism_Homo sapiens_hsa003601.56790205
53Salmonella infection_Homo sapiens_hsa051321.55359019
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54577140
55Selenocompound metabolism_Homo sapiens_hsa004501.53605782
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48865919
57Bile secretion_Homo sapiens_hsa049761.45272468
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44597040
59Toxoplasmosis_Homo sapiens_hsa051451.44484621
60Tyrosine metabolism_Homo sapiens_hsa003501.42994122
61Hematopoietic cell lineage_Homo sapiens_hsa046401.41138433
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41077657
63Sulfur metabolism_Homo sapiens_hsa009201.34185278
64Pyruvate metabolism_Homo sapiens_hsa006201.33331043
65Fatty acid elongation_Homo sapiens_hsa000621.32317665
66Antigen processing and presentation_Homo sapiens_hsa046121.29698649
67Starch and sucrose metabolism_Homo sapiens_hsa005001.29113604
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.28101249
69ABC transporters_Homo sapiens_hsa020101.20597651
70Herpes simplex infection_Homo sapiens_hsa051681.19773587
71Steroid biosynthesis_Homo sapiens_hsa001001.17204576
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.15827438
73Folate biosynthesis_Homo sapiens_hsa007901.15681523
74Biosynthesis of amino acids_Homo sapiens_hsa012301.13699163
75Phagosome_Homo sapiens_hsa041451.12985773
76Measles_Homo sapiens_hsa051621.12350552
77B cell receptor signaling pathway_Homo sapiens_hsa046621.09657958
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08796156
79Carbon metabolism_Homo sapiens_hsa012001.08137322
80Fat digestion and absorption_Homo sapiens_hsa049751.05810162
81Cyanoamino acid metabolism_Homo sapiens_hsa004601.03472137
82Maturity onset diabetes of the young_Homo sapiens_hsa049501.00840369
83Sphingolipid metabolism_Homo sapiens_hsa006000.98557181
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97051706
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96964383
86Arginine and proline metabolism_Homo sapiens_hsa003300.95737959
87Vitamin B6 metabolism_Homo sapiens_hsa007500.94478949
88Chemokine signaling pathway_Homo sapiens_hsa040620.94404246
89Viral myocarditis_Homo sapiens_hsa054160.94217775
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92859701
91Vitamin digestion and absorption_Homo sapiens_hsa049770.91873078
92Lysine degradation_Homo sapiens_hsa003100.85329050
93Sulfur relay system_Homo sapiens_hsa041220.84516356
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83882296
95Collecting duct acid secretion_Homo sapiens_hsa049660.83088216
96One carbon pool by folate_Homo sapiens_hsa006700.76227360
97Hepatitis B_Homo sapiens_hsa051610.73583802
98Amoebiasis_Homo sapiens_hsa051460.71353801
99Shigellosis_Homo sapiens_hsa051310.71326252
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69819414
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67461597
102Glutathione metabolism_Homo sapiens_hsa004800.65899258
103Glycerolipid metabolism_Homo sapiens_hsa005610.63688241
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63298965
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63192552
106T cell receptor signaling pathway_Homo sapiens_hsa046600.57521326
107Apoptosis_Homo sapiens_hsa042100.56892075
108Prolactin signaling pathway_Homo sapiens_hsa049170.56271516
109Bladder cancer_Homo sapiens_hsa052190.55516376
110Pentose phosphate pathway_Homo sapiens_hsa000300.55128242
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55061101
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52913051
113Type II diabetes mellitus_Homo sapiens_hsa049300.51824029
114Mineral absorption_Homo sapiens_hsa049780.48198921
115Epstein-Barr virus infection_Homo sapiens_hsa051690.47892159
116* Metabolic pathways_Homo sapiens_hsa011000.45128262
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43795397
118Fatty acid biosynthesis_Homo sapiens_hsa000610.42231573
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40787943
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.38022818
121Acute myeloid leukemia_Homo sapiens_hsa052210.36506273
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36085204
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34079144
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33114059
125Prion diseases_Homo sapiens_hsa050200.31873123
126VEGF signaling pathway_Homo sapiens_hsa043700.29359285
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21744041
128Galactose metabolism_Homo sapiens_hsa000520.20581777
129Insulin resistance_Homo sapiens_hsa049310.20492387
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.19315483
131Fructose and mannose metabolism_Homo sapiens_hsa000510.18354130
132Linoleic acid metabolism_Homo sapiens_hsa005910.15050878
133Ether lipid metabolism_Homo sapiens_hsa005650.14534332
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09922103
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.09257467
136FoxO signaling pathway_Homo sapiens_hsa040680.08298363
137HTLV-I infection_Homo sapiens_hsa051660.07926482
138Dorso-ventral axis formation_Homo sapiens_hsa043200.07283524
139Glucagon signaling pathway_Homo sapiens_hsa049220.05494769
140Lysosome_Homo sapiens_hsa04142-0.2358861
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2348265
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2171862
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2164206
144Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2069128
145Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.2001154
146Renin-angiotensin system_Homo sapiens_hsa04614-0.1865370
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1686639
148Pertussis_Homo sapiens_hsa05133-0.1627568
149Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1594509
150Insulin signaling pathway_Homo sapiens_hsa04910-0.1545963
151Primary immunodeficiency_Homo sapiens_hsa05340-0.1513096
152Regulation of autophagy_Homo sapiens_hsa04140-0.1282458
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1282329
154Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1223985
155African trypanosomiasis_Homo sapiens_hsa05143-0.1216183
156Hepatitis C_Homo sapiens_hsa05160-0.1209082
157Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1118849
158Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1108483
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0716310
160AMPK signaling pathway_Homo sapiens_hsa04152-0.0568149
161Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0501739

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