KMT2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30144715
2negative regulation of cell killing (GO:0031342)4.30144715
3monoubiquitinated protein deubiquitination (GO:0035520)4.29400357
4interkinetic nuclear migration (GO:0022027)3.87172004
5* histone H3-K4 trimethylation (GO:0080182)3.85876043
6* histone H3-K4 methylation (GO:0051568)3.73762314
7cerebellar Purkinje cell differentiation (GO:0021702)3.70685240
8histone H3-K9 modification (GO:0061647)3.69593622
9positive regulation of gamma-delta T cell activation (GO:0046645)3.64602222
10cytoplasmic mRNA processing body assembly (GO:0033962)3.55685674
11locomotory exploration behavior (GO:0035641)3.50446464
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.46636488
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43659601
14negative regulation of translation, ncRNA-mediated (GO:0040033)3.43659601
15regulation of translation, ncRNA-mediated (GO:0045974)3.43659601
16nuclear pore complex assembly (GO:0051292)3.30811645
17negative T cell selection (GO:0043383)3.25977381
18regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24946650
19positive T cell selection (GO:0043368)3.23296708
20regulation of ARF protein signal transduction (GO:0032012)3.20876839
21negative thymic T cell selection (GO:0045060)3.18865043
22mitotic sister chromatid cohesion (GO:0007064)3.18294096
23positive regulation by host of viral transcription (GO:0043923)3.17641339
24embryonic retina morphogenesis in camera-type eye (GO:0060059)3.16812911
25histone deubiquitination (GO:0016578)3.12467538
26positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.11179739
27pre-miRNA processing (GO:0031054)3.09865995
28positive thymic T cell selection (GO:0045059)3.08976506
29* histone lysine methylation (GO:0034968)3.06652832
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05929201
31nuclear pore organization (GO:0006999)3.05446346
32synaptic vesicle maturation (GO:0016188)3.05181681
33positive regulation of histone deacetylation (GO:0031065)3.05118997
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03367222
35regulation of histone H3-K27 methylation (GO:0061085)2.97298642
36T cell selection (GO:0045058)2.97011857
37regulation of gamma-delta T cell differentiation (GO:0045586)2.94860371
38protein K48-linked deubiquitination (GO:0071108)2.90504659
39positive regulation of gene expression, epigenetic (GO:0045815)2.89067238
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.88834257
41regulation of nucleobase-containing compound transport (GO:0032239)2.87970858
42thymic T cell selection (GO:0045061)2.87948849
43sodium ion export (GO:0071436)2.84915206
44stress granule assembly (GO:0034063)2.84546102
45central nervous system projection neuron axonogenesis (GO:0021952)2.78112140
46regulation of gamma-delta T cell activation (GO:0046643)2.77992116
47* peptidyl-lysine trimethylation (GO:0018023)2.77837910
48positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.76789428
49regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.76789428
50establishment of protein localization to Golgi (GO:0072600)2.73677315
51protein targeting to Golgi (GO:0000042)2.72893181
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70748692
53ionotropic glutamate receptor signaling pathway (GO:0035235)2.70299287
54regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.69546027
55positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.69546027
56histone lysine demethylation (GO:0070076)2.68271536
57positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68153530
58microtubule anchoring (GO:0034453)2.67936427
59glucocorticoid receptor signaling pathway (GO:0042921)2.67915633
60cellular potassium ion homeostasis (GO:0030007)2.67532220
61positive regulation of developmental pigmentation (GO:0048087)2.64847016
62positive regulation of Rap GTPase activity (GO:0032854)2.62821577
63regulation of pigment cell differentiation (GO:0050932)2.61076739
64embryonic camera-type eye morphogenesis (GO:0048596)2.57699419
65negative regulation of histone methylation (GO:0031061)2.57457342
66regulation of Rap GTPase activity (GO:0032317)2.56236857
67histone demethylation (GO:0016577)2.55416909
68protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.53596987
69establishment of nucleus localization (GO:0040023)2.53444862
70axonal fasciculation (GO:0007413)2.52492138
71coronary vasculature morphogenesis (GO:0060977)2.52052447
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51563926
73histone H3-K36 demethylation (GO:0070544)2.50682846
74mRNA splice site selection (GO:0006376)2.50089796
75negative regulation of neurotransmitter secretion (GO:0046929)2.48766849
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48426149
77histone H3-K9 demethylation (GO:0033169)2.47884592
78regulation of glutamate receptor signaling pathway (GO:1900449)2.47266764
79protein K11-linked deubiquitination (GO:0035871)2.46867373
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.46502857
81regulation of NFAT protein import into nucleus (GO:0051532)2.46221599
82forebrain neuron differentiation (GO:0021879)2.45728688
83regulation of DNA endoreduplication (GO:0032875)2.43916262
84* regulation of histone methylation (GO:0031060)2.43747504
85nerve growth factor signaling pathway (GO:0038180)2.43527114
86positive regulation of mRNA catabolic process (GO:0061014)2.43108321
87snRNA transcription (GO:0009301)2.42723062
88peptidyl-threonine phosphorylation (GO:0018107)2.42487274
89B cell receptor signaling pathway (GO:0050853)2.42425431
90spinal cord development (GO:0021510)2.42073615
91regulation of mRNA catabolic process (GO:0061013)2.41768924
92hindbrain development (GO:0030902)2.41692805
93* histone methylation (GO:0016571)2.41472300
94potassium ion import (GO:0010107)2.38494855
95central nervous system neuron axonogenesis (GO:0021955)2.35570395
96negative regulation of DNA repair (GO:0045738)2.34566033
97* regulation of histone H3-K4 methylation (GO:0051569)2.34254250
98lipid translocation (GO:0034204)2.34070760
99phospholipid translocation (GO:0045332)2.34070760
100long-term memory (GO:0007616)2.33872525
101establishment of spindle localization (GO:0051293)2.32660687
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.32340597
103sister chromatid cohesion (GO:0007062)2.32165980
104pericardium development (GO:0060039)2.31257193
105positive regulation of mRNA 3-end processing (GO:0031442)2.31095341
106chromatin silencing (GO:0006342)2.30205707
107positive regulation of RNA splicing (GO:0033120)2.29382881
108regulation of clathrin-mediated endocytosis (GO:2000369)2.29245951
109negative regulation of gene expression, epigenetic (GO:0045814)2.29038818
110* histone acetylation (GO:0016573)2.28819659
111pore complex assembly (GO:0046931)2.28384518
112vocalization behavior (GO:0071625)2.27757177
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.27497638
114regulation of ARF GTPase activity (GO:0032312)2.27085937
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.26383964
116rRNA catabolic process (GO:0016075)2.26363453
117Golgi to endosome transport (GO:0006895)2.26122903
118postsynaptic membrane organization (GO:0001941)2.25406582
119peptidyl-threonine modification (GO:0018210)2.24957928
120neuron recognition (GO:0008038)2.24879213
121positive regulation of granulocyte differentiation (GO:0030854)2.24524559
122neural tube development (GO:0021915)2.24420849
123corticosteroid receptor signaling pathway (GO:0031958)2.24417366
124response to interleukin-15 (GO:0070672)2.24213412
125insulin-like growth factor receptor signaling pathway (GO:0048009)2.24151933
126* histone H4-K16 acetylation (GO:0043984)2.24062682
127presynaptic membrane assembly (GO:0097105)2.23577912
128* peptidyl-lysine methylation (GO:0018022)2.23517910
129positive regulation of CREB transcription factor activity (GO:0032793)2.23239868
130microtubule nucleation (GO:0007020)2.20828427
131regulation of histone deacetylation (GO:0031063)2.20678002
132appendage development (GO:0048736)2.20540019
133limb development (GO:0060173)2.20540019
134regulation of mRNA 3-end processing (GO:0031440)2.20277436
135glutamate receptor signaling pathway (GO:0007215)2.20054740
136neural tube formation (GO:0001841)2.19997455
137protein dealkylation (GO:0008214)2.19974398
138protein demethylation (GO:0006482)2.19974398
139membrane depolarization during action potential (GO:0086010)2.19283293
140nucleus localization (GO:0051647)2.17464959
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.17439223
142negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.16684813
143regulation of regulatory T cell differentiation (GO:0045589)2.16482253
144cell differentiation in hindbrain (GO:0021533)2.16171889
145activated T cell proliferation (GO:0050798)2.15619611
146synaptic transmission, glutamatergic (GO:0035249)2.13725109
147dendrite morphogenesis (GO:0048813)2.12169618
148interferon-gamma production (GO:0032609)2.11609478
149synaptic vesicle exocytosis (GO:0016079)2.11284204
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.10850111
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.10598768
152histone H3-K9 methylation (GO:0051567)2.10479697
153exploration behavior (GO:0035640)2.10120663
154regulation of RNA export from nucleus (GO:0046831)2.09583793
155peptidyl-lysine dimethylation (GO:0018027)2.08078200
156cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.07446549
157positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.07374022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.89237210
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.51160650
3EZH2_22144423_ChIP-Seq_EOC_Human3.22938311
4VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.64490519
5DROSHA_22980978_ChIP-Seq_HELA_Human2.61489909
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.35636245
7MYC_22102868_ChIP-Seq_BL_Human2.35128595
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35076176
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25892967
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19593602
11RUNX_20019798_ChIP-Seq_JUKART_Human2.16774067
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10077052
13RARB_27405468_Chip-Seq_BRAIN_Mouse1.98148360
14TCF7_22412390_ChIP-Seq_EML_Mouse1.94910956
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94336414
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90774151
17KDM2B_26808549_Chip-Seq_DND41_Human1.89920806
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89591999
19GBX2_23144817_ChIP-Seq_PC3_Human1.85384419
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.82419357
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81092325
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80292850
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78768633
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72510772
25SCL_19346495_ChIP-Seq_HPC-7_Human1.69424200
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66984010
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.66617524
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65100481
29E2F7_22180533_ChIP-Seq_HELA_Human1.65071016
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61310297
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61188654
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58556046
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55332093
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54313872
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51984902
36VDR_21846776_ChIP-Seq_THP-1_Human1.51601860
37SPI1_23127762_ChIP-Seq_K562_Human1.51197127
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.48842164
39FUS_26573619_Chip-Seq_HEK293_Human1.47290456
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46672725
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45766207
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45334682
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.44910723
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.44547345
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42091535
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40741202
47KDM2B_26808549_Chip-Seq_K562_Human1.40523338
48TAF15_26573619_Chip-Seq_HEK293_Human1.40377291
49TP53_16413492_ChIP-PET_HCT116_Human1.39997282
50AR_21572438_ChIP-Seq_LNCaP_Human1.39580454
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37098301
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37063883
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36008153
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33915092
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33601106
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33229193
57ER_23166858_ChIP-Seq_MCF-7_Human1.32714992
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31361623
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29990777
60UTX_26944678_Chip-Seq_JUKART_Human1.29819244
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29172868
62AHR_22903824_ChIP-Seq_MCF-7_Human1.28186428
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27035516
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.26075335
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24754164
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24204560
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24036830
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21578519
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.21548067
70* CIITA_25753668_ChIP-Seq_RAJI_Human1.21333469
71AR_19668381_ChIP-Seq_PC3_Human1.21010069
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20939979
73MAF_26560356_Chip-Seq_TH1_Human1.20875246
74STAT3_23295773_ChIP-Seq_U87_Human1.20480924
75EWS_26573619_Chip-Seq_HEK293_Human1.20435455
76REST_21632747_ChIP-Seq_MESCs_Mouse1.20216253
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20183918
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19914732
79ZNF274_21170338_ChIP-Seq_K562_Hela1.18840275
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18751300
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18669078
82MYB_26560356_Chip-Seq_TH1_Human1.17807446
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.17614933
84MYB_26560356_Chip-Seq_TH2_Human1.17486399
85SMAD4_21799915_ChIP-Seq_A2780_Human1.17106314
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16919818
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15508864
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15156913
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15156913
90FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14741794
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.14478233
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14450795
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13454835
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13098168
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12693444
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.10945389
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10419320
98TCF4_23295773_ChIP-Seq_U87_Human1.09744308
99RNF2_27304074_Chip-Seq_NSC_Mouse1.09604509
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.09192730
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08243404
102VDR_24763502_ChIP-Seq_THP-1_Human1.08111080
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07185703
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.06617505
105SOX9_26525672_Chip-Seq_HEART_Mouse1.06390385
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05491092
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05118407
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04638426
109WDR5_24793694_ChIP-Seq_LNCAP_Human1.02654748
110KDM2B_26808549_Chip-Seq_REH_Human1.02108454
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.01984545
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01930391
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01125562
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00792810
115SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00749207
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00615473
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.00555228
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.99982436
119CBP_20019798_ChIP-Seq_JUKART_Human0.99579936
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99579936
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99512159
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99075928
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98992256
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98965937
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98810457
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.98599003
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98062113
128P300_19829295_ChIP-Seq_ESCs_Human0.97756974
129RXR_22108803_ChIP-Seq_LS180_Human0.97675862
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97139686
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96582487
132RUNX2_22187159_ChIP-Seq_PCA_Human0.95928072
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.95749667
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94076811
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93812696
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.93730251
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93053276
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93053276
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92046796
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91716137
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91711956
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.91700243
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.91458794
144NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90100617
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87958053
146SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87412059
147SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87186735
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.86918158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.00926061
2MP0004859_abnormal_synaptic_plasticity3.92374363
3MP0003787_abnormal_imprinting3.28549177
4MP0008961_abnormal_basal_metabolism2.48212750
5MP0003045_fibrosis2.35454387
6MP0003635_abnormal_synaptic_transmissio2.30865871
7MP0005423_abnormal_somatic_nervous2.21345605
8MP0003300_gastrointestinal_ulcer2.18542754
9MP0003890_abnormal_embryonic-extraembry2.13370960
10MP0003303_peritoneal_inflammation2.13260374
11MP0004808_abnormal_hematopoietic_stem2.04282712
12MP0005076_abnormal_cell_differentiation1.91275704
13MP0003763_abnormal_thymus_physiology1.86064651
14MP0005409_darkened_coat_color1.83950765
15MP0008569_lethality_at_weaning1.81777273
16MP0002166_altered_tumor_susceptibility1.79794491
17MP0009046_muscle_twitch1.76451348
18MP0004510_myositis1.72914157
19MP0009745_abnormal_behavioral_response1.70568515
20MP0003183_abnormal_peptide_metabolism1.69029993
21MP0002396_abnormal_hematopoietic_system1.68842212
22MP0009780_abnormal_chondrocyte_physiolo1.64289585
23MP0002063_abnormal_learning/memory/cond1.63815600
24MP0005174_abnormal_tail_pigmentation1.63335784
25MP0003121_genomic_imprinting1.61153479
26MP0000631_abnormal_neuroendocrine_gland1.59778575
27MP0002064_seizures1.58463908
28MP0005551_abnormal_eye_electrophysiolog1.55014172
29MP0003122_maternal_imprinting1.54796438
30MP0000703_abnormal_thymus_morphology1.52969510
31MP0001486_abnormal_startle_reflex1.52111881
32MP0001800_abnormal_humoral_immune1.48569560
33MP0009278_abnormal_bone_marrow1.48101950
34MP0002572_abnormal_emotion/affect_behav1.46220512
35MP0003861_abnormal_nervous_system1.42745096
36MP0002398_abnormal_bone_marrow1.41576728
37MP0003880_abnormal_central_pattern1.33149804
38MP0004270_analgesia1.31811505
39MP0005387_immune_system_phenotype1.30347543
40MP0001790_abnormal_immune_system1.30347543
41MP0005671_abnormal_response_to1.29992889
42MP0002006_tumorigenesis1.29886648
43MP0000428_abnormal_craniofacial_morphol1.25407966
44MP0004134_abnormal_chest_morphology1.23251562
45MP0002909_abnormal_adrenal_gland1.22736877
46MP0008995_early_reproductive_senescence1.20502894
47MP0002249_abnormal_larynx_morphology1.20101605
48MP0008877_abnormal_DNA_methylation1.18519507
49MP0006292_abnormal_olfactory_placode1.17597123
50MP0001968_abnormal_touch/_nociception1.16416387
51MP0002822_catalepsy1.15809244
52MP0006072_abnormal_retinal_apoptosis1.15560682
53MP0004130_abnormal_muscle_cell1.13773401
54MP0000383_abnormal_hair_follicle1.13251024
55MP0010094_abnormal_chromosome_stability1.11762140
56MP0002272_abnormal_nervous_system1.11197759
57MP0001188_hyperpigmentation1.10060425
58MP0002067_abnormal_sensory_capabilities1.09458134
59MP0004811_abnormal_neuron_physiology1.09318667
60MP0003937_abnormal_limbs/digits/tail_de1.09269016
61MP0003172_abnormal_lysosome_physiology1.08720317
62MP0003866_abnormal_defecation1.08053813
63MP0003935_abnormal_craniofacial_develop1.07785941
64MP0000015_abnormal_ear_pigmentation1.07693757
65MP0002557_abnormal_social/conspecific_i1.06965219
66MP0005645_abnormal_hypothalamus_physiol1.06890789
67MP0000716_abnormal_immune_system1.05164346
68MP0003115_abnormal_respiratory_system1.05085130
69MP0004742_abnormal_vestibular_system1.04054688
70MP0002420_abnormal_adaptive_immunity1.02986280
71MP0001286_abnormal_eye_development1.02674956
72MP0001501_abnormal_sleep_pattern1.01393811
73MP0005187_abnormal_penis_morphology1.01036580
74MP0004142_abnormal_muscle_tone1.00683070
75MP0001819_abnormal_immune_cell0.99282194
76MP0003942_abnormal_urinary_system0.98968949
77MP0000733_abnormal_muscle_development0.98425769
78MP0002452_abnormal_antigen_presenting0.97755643
79MP0001502_abnormal_circadian_rhythm0.97104684
80MP0000566_synostosis0.96585404
81MP0002723_abnormal_immune_serum0.95066674
82MP0003123_paternal_imprinting0.95028226
83MP0000432_abnormal_head_morphology0.94985733
84MP0004924_abnormal_behavior0.94956007
85MP0005386_behavior/neurological_phenoty0.94956007
86MP0003632_abnormal_nervous_system0.94709437
87MP0005646_abnormal_pituitary_gland0.94560343
88MP0005253_abnormal_eye_physiology0.93144213
89MP0001873_stomach_inflammation0.92891839
90MP0002081_perinatal_lethality0.92738156
91MP0000778_abnormal_nervous_system0.91244058
92MP0002116_abnormal_craniofacial_bone0.91201455
93MP0000685_abnormal_immune_system0.91103874
94MP0002084_abnormal_developmental_patter0.90693116
95MP0001485_abnormal_pinna_reflex0.89573717
96MP0010770_preweaning_lethality0.88436251
97MP0002082_postnatal_lethality0.88436251
98MP0004885_abnormal_endolymph0.88082180
99MP0002722_abnormal_immune_system0.88052672
100MP0002882_abnormal_neuron_morphology0.87694097
101MP0009703_decreased_birth_body0.87460146
102MP0001299_abnormal_eye_distance/0.87057525
103MP0004197_abnormal_fetal_growth/weight/0.85797058
104MP0010769_abnormal_survival0.85702347
105MP0003938_abnormal_ear_development0.85612680
106MP0002184_abnormal_innervation0.85567840
107MP0003385_abnormal_body_wall0.85451692
108MP0002088_abnormal_embryonic_growth/wei0.85232931
109MP0003984_embryonic_growth_retardation0.85159491
110MP0003091_abnormal_cell_migration0.85130056
111MP0010768_mortality/aging0.84300908
112MP0001835_abnormal_antigen_presentation0.84249067
113MP0004133_heterotaxia0.84220878
114MP0002735_abnormal_chemical_nociception0.83576470
115MP0002752_abnormal_somatic_nervous0.83507012
116MP0002928_abnormal_bile_duct0.82667443
117MP0000427_abnormal_hair_cycle0.81676969
118MP0001346_abnormal_lacrimal_gland0.81346256
119MP0002009_preneoplasia0.81150802
120MP0001943_abnormal_respiration0.80493580
121MP0001545_abnormal_hematopoietic_system0.80134694
122MP0005397_hematopoietic_system_phenotyp0.80134694
123MP0002089_abnormal_postnatal_growth/wei0.78955634
124MP0000689_abnormal_spleen_morphology0.78906056
125MP0005310_abnormal_salivary_gland0.78117293
126MP0002152_abnormal_brain_morphology0.77267630
127MP0000003_abnormal_adipose_tissue0.76663575
128MP0000955_abnormal_spinal_cord0.76581800
129MP0002734_abnormal_mechanical_nocicepti0.75748345
130MP0008057_abnormal_DNA_replication0.75611070
131MP0009672_abnormal_birth_weight0.74523683
132MP0000534_abnormal_ureter_morphology0.74149917
133MP0002638_abnormal_pupillary_reflex0.73303773
134MP0003077_abnormal_cell_cycle0.73151443
135MP0002429_abnormal_blood_cell0.73065435
136MP0002925_abnormal_cardiovascular_devel0.72162408
137MP0008874_decreased_physiological_sensi0.71651466
138MP0003633_abnormal_nervous_system0.69907197
139MP0002095_abnormal_skin_pigmentation0.69252291
140MP0008770_decreased_survivor_rate0.66087167
141MP0005000_abnormal_immune_tolerance0.66043259
142MP0001984_abnormal_olfaction0.65841644
143MP0004145_abnormal_muscle_electrophysio0.65602676
144MP0001440_abnormal_grooming_behavior0.64765678
145MP0001970_abnormal_pain_threshold0.63374554
146MP0003943_abnormal_hepatobiliary_system0.62664034

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.99411346
2Macroorchidism (HP:0000053)3.72507313
3Volvulus (HP:0002580)3.29482817
4Hyperventilation (HP:0002883)3.27111385
5Narrow palate (HP:0000189)2.99295995
6Genetic anticipation (HP:0003743)2.93173794
7Hyperacusis (HP:0010780)2.64162796
8Trigonocephaly (HP:0000243)2.61969785
9Obsessive-compulsive behavior (HP:0000722)2.57483717
10Obstructive sleep apnea (HP:0002870)2.52406082
11Absent frontal sinuses (HP:0002688)2.49712374
12Hemiplegia (HP:0002301)2.48710045
13Ectopic kidney (HP:0000086)2.48052268
14Hepatoblastoma (HP:0002884)2.47549893
15* Long eyelashes (HP:0000527)2.47036613
16Febrile seizures (HP:0002373)2.43656194
17Focal seizures (HP:0007359)2.42681396
18Progressive cerebellar ataxia (HP:0002073)2.36090923
19Congenital stationary night blindness (HP:0007642)2.35634609
20Dysmetric saccades (HP:0000641)2.34926043
21Urethral obstruction (HP:0000796)2.33693193
22Papilledema (HP:0001085)2.33224315
23Impaired smooth pursuit (HP:0007772)2.31077465
24T lymphocytopenia (HP:0005403)2.30209039
25Abnormality of the aortic arch (HP:0012303)2.29222828
26Vertebral arch anomaly (HP:0008438)2.29119667
27Truncal obesity (HP:0001956)2.28778305
28Lip pit (HP:0100267)2.24504265
29Aqueductal stenosis (HP:0002410)2.23508775
30Sandal gap (HP:0001852)2.22537795
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21362409
32Short 4th metacarpal (HP:0010044)2.21362409
33Anal stenosis (HP:0002025)2.20018303
34Chromsome breakage (HP:0040012)2.19810490
35Prominent nose (HP:0000448)2.19159542
36Neonatal hypoglycemia (HP:0001998)2.18121215
37Agammaglobulinemia (HP:0004432)2.17765770
38Recurrent viral infections (HP:0004429)2.14960367
39Panhypogammaglobulinemia (HP:0003139)2.12838961
40Aplasia/Hypoplasia of the sternum (HP:0006714)2.12626357
41Focal motor seizures (HP:0011153)2.10879813
42Heterotopia (HP:0002282)2.10367418
43Tented upper lip vermilion (HP:0010804)2.10261032
44Elfin facies (HP:0004428)2.09592677
45Pointed chin (HP:0000307)2.09458347
46Abnormality of the nasal septum (HP:0000419)2.07893998
47Thyroiditis (HP:0100646)2.07209145
48Abnormality of T cell number (HP:0011839)2.07140614
49Abnormality of ocular smooth pursuit (HP:0000617)2.06848862
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.03021145
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02534362
52Papillary thyroid carcinoma (HP:0002895)2.01776058
53Gaze-evoked nystagmus (HP:0000640)2.01428020
54Action tremor (HP:0002345)2.00814067
55Hypoplastic iliac wings (HP:0002866)2.00762097
56Laryngomalacia (HP:0001601)1.99482655
57Bony spicule pigmentary retinopathy (HP:0007737)1.99225868
58Deep palmar crease (HP:0006191)1.98416451
59Chronic hepatic failure (HP:0100626)1.98052733
60Truncal ataxia (HP:0002078)1.97029669
61Abnormality of the ischium (HP:0003174)1.96783905
62Abnormality of chromosome segregation (HP:0002916)1.95493753
63Abnormality of the columella (HP:0009929)1.94828225
64Abnormality of incisor morphology (HP:0011063)1.94606122
65Hypoplastic ischia (HP:0003175)1.92220236
66Low anterior hairline (HP:0000294)1.91751463
67Open mouth (HP:0000194)1.90863441
68Increased nuchal translucency (HP:0010880)1.90344949
69Abnormality of the incisor (HP:0000676)1.89709349
70Recurrent fungal infections (HP:0002841)1.89298734
71Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88918264
72Tracheomalacia (HP:0002779)1.88069232
73Syringomyelia (HP:0003396)1.87828807
74Spinal cord lesions (HP:0100561)1.87828807
75Highly arched eyebrow (HP:0002553)1.86262874
76Overgrowth (HP:0001548)1.85896164
77Midline defect of the nose (HP:0004122)1.85376942
78High anterior hairline (HP:0009890)1.84189949
79Abnormal hair whorl (HP:0010721)1.84006845
80Oligodactyly (hands) (HP:0001180)1.83862768
81Urinary bladder sphincter dysfunction (HP:0002839)1.82587424
82Epileptic encephalopathy (HP:0200134)1.81867643
83Patellar aplasia (HP:0006443)1.80003169
84Depressed nasal tip (HP:0000437)1.79506625
85Widely spaced teeth (HP:0000687)1.78727998
86Bronchomalacia (HP:0002780)1.78271869
87Smooth philtrum (HP:0000319)1.77343382
88Dislocated radial head (HP:0003083)1.77329721
89Supernumerary bones of the axial skeleton (HP:0009144)1.76276963
90Cerebral aneurysm (HP:0004944)1.76134075
91* Thick eyebrow (HP:0000574)1.74669532
92Broad face (HP:0000283)1.73628886
93Supernumerary ribs (HP:0005815)1.73623081
94Recurrent cutaneous fungal infections (HP:0011370)1.73572198
95Chronic mucocutaneous candidiasis (HP:0002728)1.73572198
96Hypoplastic labia majora (HP:0000059)1.72733314
97Abnormality of the radial head (HP:0003995)1.72657273
98Neoplasm of the heart (HP:0100544)1.72573195
99Renovascular hypertension (HP:0100817)1.72010862
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.71629310
101Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71220900
102Deep philtrum (HP:0002002)1.70662843
103Limited elbow extension (HP:0001377)1.70512808
1042-3 toe syndactyly (HP:0004691)1.70045056
105* Acute myeloid leukemia (HP:0004808)1.69826600
106Colitis (HP:0002583)1.69505501
107Abnormality of B cell number (HP:0010975)1.69328667
108B lymphocytopenia (HP:0010976)1.69328667
109Cutaneous finger syndactyly (HP:0010554)1.69004674
110Abnormal number of incisors (HP:0011064)1.68909598
111Abnormality of the intervertebral disk (HP:0005108)1.67687946
112Inflammation of the large intestine (HP:0002037)1.67664619
113Sporadic (HP:0003745)1.66862559
114Gastrointestinal inflammation (HP:0004386)1.66458350
115Excessive salivation (HP:0003781)1.66142501
116Drooling (HP:0002307)1.66142501
117Abnormality of the 4th metacarpal (HP:0010012)1.66121354
118Mask-like facies (HP:0000298)1.65304268
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64733739
120Exotropia (HP:0000577)1.64423014
121Visual hallucinations (HP:0002367)1.63971655
122Neoplasm of the adrenal cortex (HP:0100641)1.63410818
123Partial agenesis of the corpus callosum (HP:0001338)1.63399321
124Gastroesophageal reflux (HP:0002020)1.62483347
125Diplopia (HP:0000651)1.62213513
126Abnormality of binocular vision (HP:0011514)1.62213513
127Diastasis recti (HP:0001540)1.61996543
128Poor coordination (HP:0002370)1.60962496
129Hypoplasia of the maxilla (HP:0000327)1.60892583
130Recurrent bronchitis (HP:0002837)1.60697826
131Broad palm (HP:0001169)1.60439303
132Absent speech (HP:0001344)1.60339549
133Abnormality of the pubic bones (HP:0003172)1.59414375
134Stereotypic behavior (HP:0000733)1.59168039
135Short chin (HP:0000331)1.59004836
136Shawl scrotum (HP:0000049)1.58168602
137Cystic hygroma (HP:0000476)1.57965131
138* Broad-based gait (HP:0002136)1.57846468
139Abnormality of oral frenula (HP:0000190)1.57842919
140Clumsiness (HP:0002312)1.57635319
141Broad thumb (HP:0011304)1.57171176
142Abnormality of the labia majora (HP:0012881)1.56907223
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.56035568
144Central scotoma (HP:0000603)1.56017337
145Insomnia (HP:0100785)1.54419161
146Lower limb amyotrophy (HP:0007210)1.54247922
147Inappropriate behavior (HP:0000719)1.54209889
148Skin tags (HP:0010609)1.54050058
149Attention deficit hyperactivity disorder (HP:0007018)1.52806493
150Papilloma (HP:0012740)1.52650415
151Verrucae (HP:0200043)1.52650415
152Cellulitis (HP:0100658)1.52234544
153Chronic otitis media (HP:0000389)1.52096890
154* Tapered finger (HP:0001182)1.51983309
155Transitional cell carcinoma of the bladder (HP:0006740)1.50675174
156Long palpebral fissure (HP:0000637)1.50116647
157Lymphopenia (HP:0001888)1.49657816
158Protruding tongue (HP:0010808)1.49362688
159Cutis marmorata (HP:0000965)1.48739978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.99870628
2CAMK1G3.46957645
3FRK3.03049338
4SIK23.01284083
5BRD42.74345920
6CAMK1D2.65554587
7MAP4K12.47747030
8NTRK32.44489580
9CASK2.27194675
10MARK12.24191176
11AKT32.05260229
12MAP3K101.77909111
13FES1.73784114
14TRIB31.61886434
15EEF2K1.60848865
16SGK31.55644546
17PNCK1.53452704
18PRKCH1.49998319
19FGFR31.44111899
20DMPK1.41481844
21JAK11.41122691
22MARK21.39009359
23NLK1.38626458
24TXK1.36584649
25SGK21.35639055
26TAOK11.34452973
27RIPK11.33289507
28MAP3K41.30674411
29CDC42BPA1.28603538
30WNK11.27984185
31NTRK21.25742310
32MAP3K71.24918790
33MAP3K131.21356519
34ALK1.20480201
35ITK1.19836645
36HIPK21.17210278
37RIPK41.11902742
38PRKD21.09476744
39TNK21.08413913
40EPHA41.07446160
41HCK1.05912660
42MELK0.99911559
43NEK20.99397992
44LATS10.98052198
45CAMK10.97115166
46PDGFRB0.96393432
47CAMK40.96206975
48FGFR20.94216090
49CDK30.93667066
50INSRR0.92330986
51STK110.91698978
52CDK90.91597479
53TAOK30.90980500
54SIK30.90774855
55JAK30.90160875
56CAMKK20.89277416
57MTOR0.88863818
58SYK0.88571354
59SGK10.85768280
60CDC70.84502676
61MAP3K90.83361222
62SIK10.81666212
63YES10.81544853
64BTK0.79838991
65TNIK0.78979897
66CAMKK10.77998056
67PRKD30.76083869
68KSR10.75323535
69ICK0.74352376
70STK380.74132661
71PRPF4B0.72143025
72STK100.71316666
73TYK20.70934166
74GRK60.70550231
75SGK2230.70406822
76SGK4940.70406822
77TRPM70.70283007
78PRKAA10.68225389
79LCK0.67402673
80MAPK130.66931560
81PTK60.65891799
82UHMK10.63555065
83TYRO30.63211674
84RET0.62495216
85* ATR0.61945450
86MAPK100.61519838
87DAPK20.61352313
88CDK20.61328018
89PRKCQ0.60982749
90FGFR40.60796795
91BMPR1B0.60113490
92CDK10.59399205
93CDK50.59184187
94WNK30.58353890
95ZAP700.58110448
96PAK30.57816626
97MAPK80.57716989
98GSK3B0.57172696
99MAP3K20.56991291
100MAPK140.56689180
101CDK60.56416376
102ERBB20.56094595
103RPS6KA30.55491615
104PKN20.55129730
105MKNK20.55043015
106EPHB10.54884265
107FYN0.54854534
108CHUK0.54104335
109PAK60.53546250
110MAPK70.53321613
111TEC0.52867432
112CSNK1E0.52864729
113CDK40.52542606
114PRKD10.51548936
115PRKDC0.51478303
116AKT10.51243366
117IKBKE0.50270496
118MARK30.49820906
119TTN0.48813613
120ATM0.48675371
121KIT0.48589560
122PDK10.47922501
123DYRK1A0.46849239
124MAPK10.46723009
125CLK10.46298860
126CSK0.46222033
127RPS6KA20.46186143
128CHEK10.45764736
129CSNK1A1L0.45054444
130RPS6KB10.42510324
131WNK40.42168877
132PRKAA20.41977744
133CSNK1D0.39107788
134CHEK20.38263288
135CDK70.36544996
136BRSK20.35133195
137FGFR10.34157050
138TAF10.33390528
139PIK3CA0.33279828

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047441.90823125
2Primary immunodeficiency_Homo sapiens_hsa053401.76818488
3Long-term potentiation_Homo sapiens_hsa047201.71767169
4Nicotine addiction_Homo sapiens_hsa050331.69401374
5Circadian entrainment_Homo sapiens_hsa047131.66459649
6Type II diabetes mellitus_Homo sapiens_hsa049301.63756203
7Olfactory transduction_Homo sapiens_hsa047401.62721414
8Morphine addiction_Homo sapiens_hsa050321.54284708
9Glutamatergic synapse_Homo sapiens_hsa047241.53799506
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51082665
11Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50884941
12B cell receptor signaling pathway_Homo sapiens_hsa046621.48740345
13Insulin secretion_Homo sapiens_hsa049111.38971920
14T cell receptor signaling pathway_Homo sapiens_hsa046601.38941479
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36338035
16Cholinergic synapse_Homo sapiens_hsa047251.31908826
17GABAergic synapse_Homo sapiens_hsa047271.31574003
18Amphetamine addiction_Homo sapiens_hsa050311.28574073
19Salivary secretion_Homo sapiens_hsa049701.27900699
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27433426
21Dopaminergic synapse_Homo sapiens_hsa047281.24755046
22Gastric acid secretion_Homo sapiens_hsa049711.21515691
23* Lysine degradation_Homo sapiens_hsa003101.16684319
24Adherens junction_Homo sapiens_hsa045201.15886024
25Glioma_Homo sapiens_hsa052141.15709424
26Oxytocin signaling pathway_Homo sapiens_hsa049211.15299888
27Renin secretion_Homo sapiens_hsa049241.15117644
28Dorso-ventral axis formation_Homo sapiens_hsa043201.14605444
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12730713
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12484522
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11424143
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.09704549
33mTOR signaling pathway_Homo sapiens_hsa041501.09630872
34GnRH signaling pathway_Homo sapiens_hsa049121.09252648
35cAMP signaling pathway_Homo sapiens_hsa040241.08610407
36Long-term depression_Homo sapiens_hsa047301.07130362
37Chronic myeloid leukemia_Homo sapiens_hsa052201.07108366
38Non-small cell lung cancer_Homo sapiens_hsa052231.06632251
39Cocaine addiction_Homo sapiens_hsa050301.06445935
40Fanconi anemia pathway_Homo sapiens_hsa034601.06406424
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05954287
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05764856
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04918398
44Osteoclast differentiation_Homo sapiens_hsa043801.03857934
45Basal cell carcinoma_Homo sapiens_hsa052171.01470684
46Estrogen signaling pathway_Homo sapiens_hsa049151.01245231
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00649607
48ErbB signaling pathway_Homo sapiens_hsa040121.00367718
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99214734
50Calcium signaling pathway_Homo sapiens_hsa040200.99109298
51Chemokine signaling pathway_Homo sapiens_hsa040620.98652683
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97382883
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.96902531
54Taste transduction_Homo sapiens_hsa047420.95368985
55Inositol phosphate metabolism_Homo sapiens_hsa005620.95249968
56Non-homologous end-joining_Homo sapiens_hsa034500.94483325
57MAPK signaling pathway_Homo sapiens_hsa040100.94330895
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94152061
59Synaptic vesicle cycle_Homo sapiens_hsa047210.92634880
60Platelet activation_Homo sapiens_hsa046110.92574786
61Choline metabolism in cancer_Homo sapiens_hsa052310.92449938
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91934464
63Dilated cardiomyopathy_Homo sapiens_hsa054140.88523042
64Endometrial cancer_Homo sapiens_hsa052130.87806102
65Thyroid cancer_Homo sapiens_hsa052160.86949952
66Hedgehog signaling pathway_Homo sapiens_hsa043400.86419307
67Cell cycle_Homo sapiens_hsa041100.85958232
68Acute myeloid leukemia_Homo sapiens_hsa052210.85458730
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84354397
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83616859
71Notch signaling pathway_Homo sapiens_hsa043300.82836420
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.82136068
73Colorectal cancer_Homo sapiens_hsa052100.81927817
74Melanoma_Homo sapiens_hsa052180.80140228
75Hippo signaling pathway_Homo sapiens_hsa043900.79894579
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77818243
77Gap junction_Homo sapiens_hsa045400.77651335
78Melanogenesis_Homo sapiens_hsa049160.76853259
79Glucagon signaling pathway_Homo sapiens_hsa049220.76757653
80Pancreatic cancer_Homo sapiens_hsa052120.76631636
81MicroRNAs in cancer_Homo sapiens_hsa052060.76629475
82Serotonergic synapse_Homo sapiens_hsa047260.75877673
83Prolactin signaling pathway_Homo sapiens_hsa049170.74312243
84Rap1 signaling pathway_Homo sapiens_hsa040150.73947823
85Ras signaling pathway_Homo sapiens_hsa040140.73310858
86* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73133872
87TGF-beta signaling pathway_Homo sapiens_hsa043500.71713252
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71677281
89VEGF signaling pathway_Homo sapiens_hsa043700.71581053
90Proteoglycans in cancer_Homo sapiens_hsa052050.71281483
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71269002
92Measles_Homo sapiens_hsa051620.70849928
93Renal cell carcinoma_Homo sapiens_hsa052110.70549836
94Viral myocarditis_Homo sapiens_hsa054160.70288311
95Hematopoietic cell lineage_Homo sapiens_hsa046400.70081026
96Pancreatic secretion_Homo sapiens_hsa049720.69945219
97Prostate cancer_Homo sapiens_hsa052150.69840509
98Hepatitis B_Homo sapiens_hsa051610.69510100
99FoxO signaling pathway_Homo sapiens_hsa040680.69124549
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68818366
101Axon guidance_Homo sapiens_hsa043600.68398718
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68185317
103Wnt signaling pathway_Homo sapiens_hsa043100.67884732
104Pathways in cancer_Homo sapiens_hsa052000.67738405
105AMPK signaling pathway_Homo sapiens_hsa041520.67473804
106Thyroid hormone synthesis_Homo sapiens_hsa049180.67397379
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67176110
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67063514
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.67009903
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66754282
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.66631093
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.65310602
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63866779
114HTLV-I infection_Homo sapiens_hsa051660.63425848
115Small cell lung cancer_Homo sapiens_hsa052220.63320779
116mRNA surveillance pathway_Homo sapiens_hsa030150.62827163
117Insulin signaling pathway_Homo sapiens_hsa049100.62260747
118Circadian rhythm_Homo sapiens_hsa047100.62096509
119Insulin resistance_Homo sapiens_hsa049310.61990787
120Oocyte meiosis_Homo sapiens_hsa041140.55760735
121ABC transporters_Homo sapiens_hsa020100.54342025

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