KMT2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.57716485
2mannose metabolic process (GO:0006013)4.24928368
3positive regulation of histone deacetylation (GO:0031065)4.11412512
4positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.02810751
5negative regulation of histone methylation (GO:0031061)3.98687297
6heterochromatin organization (GO:0070828)3.94914979
7cytoplasmic mRNA processing body assembly (GO:0033962)3.93012547
8nuclear pore complex assembly (GO:0051292)3.88195251
9intracellular estrogen receptor signaling pathway (GO:0030520)3.75468501
10regulation of gamma-delta T cell differentiation (GO:0045586)3.70821232
11regulation of histone H3-K27 methylation (GO:0061085)3.70511481
12histone H4-K12 acetylation (GO:0043983)3.65383974
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64756984
14positive thymic T cell selection (GO:0045059)3.60717700
15response to muramyl dipeptide (GO:0032495)3.60310291
16nuclear pore organization (GO:0006999)3.54517475
17histone H3-K36 demethylation (GO:0070544)3.51208418
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50280087
19histone H4-K16 acetylation (GO:0043984)3.50183340
20regulation of RNA export from nucleus (GO:0046831)3.49145388
21mRNA stabilization (GO:0048255)3.48864323
22RNA stabilization (GO:0043489)3.48864323
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45820587
24positive regulation of gamma-delta T cell activation (GO:0046645)3.41963654
25regulation of NFAT protein import into nucleus (GO:0051532)3.41197646
26antigen processing and presentation of endogenous antigen (GO:0019883)3.38261270
27regulation of hippo signaling (GO:0035330)3.35010148
28regulation of gamma-delta T cell activation (GO:0046643)3.31214882
29histone H4-K8 acetylation (GO:0043982)3.31153702
30histone H4-K5 acetylation (GO:0043981)3.31153702
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30948967
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.30948967
33modulation by symbiont of host immune response (GO:0052553)3.30948967
34positive regulation by symbiont of host defense response (GO:0052509)3.30948967
35modulation by symbiont of host defense response (GO:0052031)3.30948967
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30948967
37* histone H3-K4 methylation (GO:0051568)3.28740441
38NLS-bearing protein import into nucleus (GO:0006607)3.28603746
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27915167
40glucocorticoid receptor signaling pathway (GO:0042921)3.22778245
41peptidyl-lysine dimethylation (GO:0018027)3.22187013
42positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.21302071
43regulation of ARF GTPase activity (GO:0032312)3.17888777
44modulation by virus of host process (GO:0019054)3.17347085
45response to laminar fluid shear stress (GO:0034616)3.12176077
46regulation of translational fidelity (GO:0006450)3.08637954
47histone H3-K9 demethylation (GO:0033169)3.08140802
48leukocyte aggregation (GO:0070486)3.06516244
49histone lysine demethylation (GO:0070076)3.05826706
50negative regulation of cell killing (GO:0031342)3.03451198
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03451198
52regulation of posttranscriptional gene silencing (GO:0060147)3.01952498
53regulation of gene silencing by miRNA (GO:0060964)3.01952498
54regulation of gene silencing by RNA (GO:0060966)3.01952498
55thymic T cell selection (GO:0045061)3.01859557
56modulation by symbiont of host cellular process (GO:0044068)3.00925813
57regulation of histone H3-K9 methylation (GO:0051570)2.98364458
58germinal center formation (GO:0002467)2.97230779
59mitotic sister chromatid cohesion (GO:0007064)2.95761831
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.95657963
61regulation of type I interferon-mediated signaling pathway (GO:0060338)2.93473453
62chromatin assembly (GO:0031497)2.93424966
63regulation of nucleobase-containing compound transport (GO:0032239)2.93407933
64gene silencing by RNA (GO:0031047)2.93133737
65chromatin silencing (GO:0006342)2.92572568
66histone H2A monoubiquitination (GO:0035518)2.92434842
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92421714
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.92421714
69regulation of translation, ncRNA-mediated (GO:0045974)2.92421714
70activation of Rac GTPase activity (GO:0032863)2.91858382
71negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91666844
72histone demethylation (GO:0016577)2.91262939
73trophectodermal cell differentiation (GO:0001829)2.90209526
74spliceosomal tri-snRNP complex assembly (GO:0000244)2.89699662
75macrophage activation involved in immune response (GO:0002281)2.89675163
76detection of bacterium (GO:0016045)2.89186897
77* histone lysine methylation (GO:0034968)2.89117952
78regulation of chromatin binding (GO:0035561)2.88774645
79stress granule assembly (GO:0034063)2.88216952
80response to peptidoglycan (GO:0032494)2.88201308
81dosage compensation (GO:0007549)2.87930607
82regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.85149493
83negative regulation of mRNA processing (GO:0050686)2.84721955
84regulation of sister chromatid cohesion (GO:0007063)2.84010219
85positive regulation of protein deacetylation (GO:0090312)2.83853947
86positive T cell selection (GO:0043368)2.83804836
87cellular response to virus (GO:0098586)2.83555100
88positive regulation of RNA splicing (GO:0033120)2.83477934
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.83469831
90tolerance induction (GO:0002507)2.81171362
91regulation of ARF protein signal transduction (GO:0032012)2.81100171
92detection of other organism (GO:0098543)2.80611803
93* gene silencing (GO:0016458)2.79625335
94negative regulation of mRNA metabolic process (GO:1903312)2.78810188
95pore complex assembly (GO:0046931)2.78736348
96corticosteroid receptor signaling pathway (GO:0031958)2.77484399
97negative regulation of viral release from host cell (GO:1902187)2.76697428
98NIK/NF-kappaB signaling (GO:0038061)2.73107315
99signal complex assembly (GO:0007172)2.71933786
100histone H3-K9 methylation (GO:0051567)2.71436373
101negative regulation of RNA splicing (GO:0033119)2.70730568
102apoptotic process involved in morphogenesis (GO:0060561)2.69956310
103histone H4 deacetylation (GO:0070933)2.67443495
104histone H4 acetylation (GO:0043967)2.67167231
105establishment of apical/basal cell polarity (GO:0035089)2.66630208
106positive regulation of Rap GTPase activity (GO:0032854)2.66478114
107protein demethylation (GO:0006482)2.64297139
108protein dealkylation (GO:0008214)2.64297139
109T cell selection (GO:0045058)2.63998552
110protein-DNA complex disassembly (GO:0032986)2.63025135
111nucleosome disassembly (GO:0006337)2.63025135
112* positive regulation of gene expression, epigenetic (GO:0045815)2.62805648
113histone H3-K9 modification (GO:0061647)2.62077951
114adherens junction assembly (GO:0034333)2.61457958
115activation of JUN kinase activity (GO:0007257)2.60436521
116negative regulation of histone modification (GO:0031057)2.59682220
117* histone methylation (GO:0016571)2.59332633
118regulation of interferon-beta biosynthetic process (GO:0045357)2.59067129
119negative regulation of gene expression, epigenetic (GO:0045814)2.58790969
120positive regulation of SMAD protein import into nucleus (GO:0060391)2.58662244
121positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58511885
122B cell receptor signaling pathway (GO:0050853)2.57097800
123mitotic G1 DNA damage checkpoint (GO:0031571)2.57093374
124DNA duplex unwinding (GO:0032508)2.56946176
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.55857030
126DNA geometric change (GO:0032392)2.54522910
127regulation of mRNA stability (GO:0043488)2.54434751
128protein localization to kinetochore (GO:0034501)2.53706828
129CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.52382460
130sister chromatid segregation (GO:0000819)2.52299013
131negative regulation of myotube differentiation (GO:0010832)2.52209585
132embryonic placenta development (GO:0001892)2.51374398
133antigen processing and presentation via MHC class Ib (GO:0002475)2.51151062
134negative thymic T cell selection (GO:0045060)2.50190313
135semaphorin-plexin signaling pathway (GO:0071526)2.50179797
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50035726
137negative regulation of chromatin modification (GO:1903309)2.49008643
138histone H3 acetylation (GO:0043966)2.48588227
139negative regulation of cell size (GO:0045792)2.48568831
140histone acetylation (GO:0016573)2.47891017
141positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47557527
142internal peptidyl-lysine acetylation (GO:0018393)2.47453010
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47333056
144negative regulation of erythrocyte differentiation (GO:0045647)2.47124908
1453-UTR-mediated mRNA stabilization (GO:0070935)2.46274061
146negative T cell selection (GO:0043383)2.46167632
147positive regulation of CREB transcription factor activity (GO:0032793)2.46126634
148negative regulation of fatty acid transport (GO:2000192)2.45346009
149cell-substrate adherens junction assembly (GO:0007045)2.44134519
150focal adhesion assembly (GO:0048041)2.44134519
151embryonic process involved in female pregnancy (GO:0060136)2.43764456
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.43562043
153response to type I interferon (GO:0034340)2.42572484
154cell-cell junction maintenance (GO:0045217)2.38108723
155poly(A)+ mRNA export from nucleus (GO:0016973)2.37843037
156detection of external biotic stimulus (GO:0098581)2.35465387
157type I interferon signaling pathway (GO:0060337)2.34371945
158cellular response to type I interferon (GO:0071357)2.34371945
159regulation of T-helper 2 cell differentiation (GO:0045628)2.34311745
160cellular response to epidermal growth factor stimulus (GO:0071364)2.33625583
161regulation of extracellular matrix disassembly (GO:0010715)2.32808485
162regulation of T cell tolerance induction (GO:0002664)2.32349169
163Peyers patch development (GO:0048541)2.32057968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.26891517
2MYC_22102868_ChIP-Seq_BL_Human4.14478636
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.64689551
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51658058
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.45096482
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.08296385
7TCF7_22412390_ChIP-Seq_EML_Mouse2.84182525
8KDM2B_26808549_Chip-Seq_DND41_Human2.82372375
9VDR_21846776_ChIP-Seq_THP-1_Human2.72033128
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.63796695
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61636394
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59421807
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.57983123
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.41567733
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19206338
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17328803
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.10965714
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.02528624
19KDM2B_26808549_Chip-Seq_JURKAT_Human1.96886406
20UTX_26944678_Chip-Seq_JUKART_Human1.94889764
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93541017
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89456905
23MAF_26560356_Chip-Seq_TH1_Human1.88921558
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85571843
25KDM2B_26808549_Chip-Seq_K562_Human1.81429833
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80450363
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70445563
28LXR_22292898_ChIP-Seq_THP-1_Human1.70256250
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67037106
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67037106
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67037106
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65466911
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64248073
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64211344
35CIITA_25753668_ChIP-Seq_RAJI_Human1.60573546
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.60009340
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57229199
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55882185
39RACK7_27058665_Chip-Seq_MCF-7_Human1.54891275
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54339488
41NCOR1_26117541_ChIP-Seq_K562_Human1.53369360
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51359027
43SMC4_20622854_ChIP-Seq_HELA_Human1.51104573
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.50807413
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.49240903
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48997601
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.48621198
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.48345076
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44632092
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42807067
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40377161
52MYB_26560356_Chip-Seq_TH1_Human1.39001048
53SCL_19346495_ChIP-Seq_HPC-7_Human1.38754724
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38387570
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35707475
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33900278
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33784726
58VDR_24763502_ChIP-Seq_THP-1_Human1.33736539
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.30469648
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29747693
61CREB1_26743006_Chip-Seq_LNCaP_Human1.29420880
62MAF_26560356_Chip-Seq_TH2_Human1.29199029
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28102738
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.26972700
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25715629
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25573655
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24583834
68PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24369537
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24034388
70BCOR_27268052_Chip-Seq_Bcells_Human1.21975128
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20726504
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20430469
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20224729
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19733542
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.19325571
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18296476
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18241042
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.18133473
79SPI1_23127762_ChIP-Seq_K562_Human1.17979458
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17312481
81MYB_26560356_Chip-Seq_TH2_Human1.16795066
82ZNF263_19887448_ChIP-Seq_K562_Human1.16374277
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15600082
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.15160547
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15135226
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15079886
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14612018
88P68_20966046_ChIP-Seq_HELA_Human1.13746964
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13209773
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12831765
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.12453482
92ATF3_27146783_Chip-Seq_COLON_Human1.10951923
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10843397
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.10275766
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10021727
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09497352
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09325275
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08355420
99TP53_22127205_ChIP-Seq_IMR90_Human1.07854719
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07816451
101RUNX1_22412390_ChIP-Seq_EML_Mouse1.07275989
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07265506
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07038420
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06898036
105TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06651266
106NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06598289
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06452202
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.05607794
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.05460056
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05275502
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04850165
112BCL6_27268052_Chip-Seq_Bcells_Human1.04309409
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03949683
114GATA1_19941826_ChIP-Seq_K562_Human1.03384270
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03227836
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03227728
117RUNX_20019798_ChIP-Seq_JUKART_Human1.02495353
118KDM5A_27292631_Chip-Seq_BREAST_Human1.02183012
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01559604
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00817281
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00613542
122E2F1_21310950_ChIP-Seq_MCF-7_Human0.99936798
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99860019
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99822479
125GATA6_25053715_ChIP-Seq_YYC3_Human0.99448158
126CHD1_26751641_Chip-Seq_LNCaP_Human0.97214655
127CTCF_27219007_Chip-Seq_Bcells_Human0.97201844
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97198541
129ELF1_20517297_ChIP-Seq_JURKAT_Human0.97190992
130DROSHA_22980978_ChIP-Seq_HELA_Human0.97157322
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96992045
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96174895
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96123427
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95809718
135TP63_22573176_ChIP-Seq_HFKS_Human0.94750339
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94105069
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93739280
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93255753
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92316607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.60721953
2MP0003436_decreased_susceptibility_to3.32230090
3MP0003705_abnormal_hypodermis_morpholog3.31424898
4MP0009278_abnormal_bone_marrow3.10432658
5MP0010352_gastrointestinal_tract_polyps3.01124008
6MP0005451_abnormal_body_composition2.89467693
7MP0008961_abnormal_basal_metabolism2.48571470
8MP0008260_abnormal_autophagy2.32018727
9MP0008057_abnormal_DNA_replication2.30318490
10MP0003300_gastrointestinal_ulcer2.28588133
11MP0003111_abnormal_nucleus_morphology2.08352421
12MP0005058_abnormal_lysosome_morphology2.07009320
13MP0001849_ear_inflammation2.05847772
14MP0004264_abnormal_extraembryonic_tissu2.04387445
15MP0000569_abnormal_digit_pigmentation2.04248910
16MP0005409_darkened_coat_color2.02413594
17MP0003303_peritoneal_inflammation2.00660100
18MP0002396_abnormal_hematopoietic_system1.97429888
19MP0004381_abnormal_hair_follicle1.93990729
20MP0003787_abnormal_imprinting1.89782681
21MP0009333_abnormal_splenocyte_physiolog1.89059534
22MP0001348_abnormal_lacrimal_gland1.88603991
23MP0002653_abnormal_ependyma_morphology1.88499000
24MP0001835_abnormal_antigen_presentation1.85983117
25MP0004197_abnormal_fetal_growth/weight/1.85891437
26MP0004808_abnormal_hematopoietic_stem1.83306665
27MP0008877_abnormal_DNA_methylation1.81842653
28MP0010307_abnormal_tumor_latency1.76682041
29MP0001730_embryonic_growth_arrest1.75458886
30MP0000678_abnormal_parathyroid_gland1.73864595
31MP0005380_embryogenesis_phenotype1.73517755
32MP0001672_abnormal_embryogenesis/_devel1.73517755
33MP0005025_abnormal_response_to1.73316091
34MP0005000_abnormal_immune_tolerance1.72087928
35MP0002086_abnormal_extraembryonic_tissu1.71080663
36MP0002084_abnormal_developmental_patter1.70906353
37MP0010234_abnormal_vibrissa_follicle1.69237396
38MP0003984_embryonic_growth_retardation1.69200428
39MP0002088_abnormal_embryonic_growth/wei1.68195896
40MP0002249_abnormal_larynx_morphology1.64864351
41MP0002419_abnormal_innate_immunity1.63848679
42MP0000350_abnormal_cell_proliferation1.63540385
43MP0004858_abnormal_nervous_system1.63347648
44MP0003077_abnormal_cell_cycle1.61453408
45MP0002420_abnormal_adaptive_immunity1.58818556
46MP0002723_abnormal_immune_serum1.58218977
47MP0001819_abnormal_immune_cell1.57370780
48MP0003566_abnormal_cell_adhesion1.56542404
49MP0004185_abnormal_adipocyte_glucose1.56125438
50MP0005397_hematopoietic_system_phenotyp1.55996995
51MP0001545_abnormal_hematopoietic_system1.55996995
52MP0000733_abnormal_muscle_development1.50845628
53MP0002085_abnormal_embryonic_tissue1.50673898
54MP0002452_abnormal_antigen_presenting1.49917335
55MP0003890_abnormal_embryonic-extraembry1.49012358
56MP0000685_abnormal_immune_system1.48580187
57MP0000703_abnormal_thymus_morphology1.48195545
58MP0005671_abnormal_response_to1.45385215
59MP0003763_abnormal_thymus_physiology1.41111238
60MP0003045_fibrosis1.40101181
61MP0010094_abnormal_chromosome_stability1.38654730
62MP0003283_abnormal_digestive_organ1.38544441
63MP0001697_abnormal_embryo_size1.37906557
64MP0004957_abnormal_blastocyst_morpholog1.37894219
65MP0002925_abnormal_cardiovascular_devel1.34883820
66MP0002398_abnormal_bone_marrow1.32145219
67MP0003121_genomic_imprinting1.31825823
68MP0005310_abnormal_salivary_gland1.31408495
69MP0002089_abnormal_postnatal_growth/wei1.30684755
70MP0000858_altered_metastatic_potential1.27808289
71MP0003115_abnormal_respiratory_system1.26178472
72MP0002166_altered_tumor_susceptibility1.26003929
73MP0002080_prenatal_lethality1.23390874
74MP0005623_abnormal_meninges_morphology1.21227450
75MP0001533_abnormal_skeleton_physiology1.20807693
76MP0009840_abnormal_foam_cell1.20314689
77MP0003183_abnormal_peptide_metabolism1.19864315
78MP0010630_abnormal_cardiac_muscle1.19657427
79MP0002877_abnormal_melanocyte_morpholog1.19353680
80MP0002998_abnormal_bone_remodeling1.18863769
81MP0003119_abnormal_digestive_system1.18103826
82MP0001915_intracranial_hemorrhage1.17936376
83MP0009703_decreased_birth_body1.14510018
84MP0003724_increased_susceptibility_to1.14044454
85MP0005023_abnormal_wound_healing1.13679692
86MP0001800_abnormal_humoral_immune1.13339874
87MP0003091_abnormal_cell_migration1.10619562
88MP0003191_abnormal_cellular_cholesterol1.09659605
89MP0003567_abnormal_fetal_cardiomyocyte1.08304045
90MP0008770_decreased_survivor_rate1.08112738
91MP0009672_abnormal_birth_weight1.06157754
92MP0002722_abnormal_immune_system1.05232013
93MP0004947_skin_inflammation1.01042311
94MP0002796_impaired_skin_barrier1.00656182
95MP0002009_preneoplasia1.00184197
96MP0000428_abnormal_craniofacial_morphol1.00123684
97MP0001790_abnormal_immune_system0.99592492
98MP0005387_immune_system_phenotype0.99592492
99MP0003935_abnormal_craniofacial_develop0.99455073
100MP0003866_abnormal_defecation0.99058125
101MP0001851_eye_inflammation0.98256824
102MP0000266_abnormal_heart_morphology0.98215790
103MP0001784_abnormal_fluid_regulation0.97553668
104MP0000689_abnormal_spleen_morphology0.97225579
105MP0004510_myositis0.94068163
106MP0002092_abnormal_eye_morphology0.93711787
107MP0002138_abnormal_hepatobiliary_system0.92613965
108MP0003123_paternal_imprinting0.92455041
109MP0008995_early_reproductive_senescence0.91796943
110MP0002019_abnormal_tumor_incidence0.90677135
111MP0005666_abnormal_adipose_tissue0.90623127
112MP0002933_joint_inflammation0.90615105
113MP0009785_altered_susceptibility_to0.90113197
114MP0009931_abnormal_skin_appearance0.88813196
115MP0000716_abnormal_immune_system0.87529364
116MP0005375_adipose_tissue_phenotype0.87284261
117MP0005464_abnormal_platelet_physiology0.86279864
118MP0000490_abnormal_crypts_of0.85736403
119MP0004233_abnormal_muscle_weight0.85717749
120MP0003453_abnormal_keratinocyte_physiol0.84954067
121MP0002405_respiratory_system_inflammati0.84918837
122MP0003279_aneurysm0.84837527
123MP0001873_stomach_inflammation0.84744510
124MP0002697_abnormal_eye_size0.83832796
125MP0000313_abnormal_cell_death0.82953695
126MP0005621_abnormal_cell_physiology0.82450967
127MP0001845_abnormal_inflammatory_respons0.81710976
128MP0003828_pulmonary_edema0.80866300
129MP0002429_abnormal_blood_cell0.80205900
130MP0002006_tumorigenesis0.79154503
131MP0000003_abnormal_adipose_tissue0.78399187
132MP0003693_abnormal_embryo_hatching0.78368208
133MP0003172_abnormal_lysosome_physiology0.77762610
134MP0010155_abnormal_intestine_physiology0.77189796
135MP0002970_abnormal_white_adipose0.76458020
136MP0000537_abnormal_urethra_morphology0.75391670
137MP0002132_abnormal_respiratory_system0.75276287
138MP0000767_abnormal_smooth_muscle0.75120153
139MP0003861_abnormal_nervous_system0.73923512
140MP0005670_abnormal_white_adipose0.73441827
141MP0000432_abnormal_head_morphology0.72624572
142MP0002254_reproductive_system_inflammat0.71818501
143MP0009115_abnormal_fat_cell0.71366132
144MP0004087_abnormal_muscle_fiber0.70100651
145MP0005390_skeleton_phenotype0.69707145
146MP0001293_anophthalmia0.69120957
147MP0001958_emphysema0.66547562
148MP0006082_CNS_inflammation0.66517340
149MP0002148_abnormal_hypersensitivity_rea0.65559035
150MP0005501_abnormal_skin_physiology0.65028942

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.21699253
2Abnormality of the fingertips (HP:0001211)4.15095110
3Ependymoma (HP:0002888)3.59060045
4Hyperacusis (HP:0010780)3.55414640
5Broad face (HP:0000283)3.50810432
6Eczematoid dermatitis (HP:0000976)3.47239586
7Cerebral aneurysm (HP:0004944)3.20706638
8Abnormality of the astrocytes (HP:0100707)3.07620704
9Astrocytoma (HP:0009592)3.07620704
10Macroorchidism (HP:0000053)2.91071991
11Heterotopia (HP:0002282)2.90162878
12Urethral obstruction (HP:0000796)2.81206110
13Abnormality of the lower motor neuron (HP:0002366)2.80374174
14Increased IgE level (HP:0003212)2.71318254
15Long eyelashes (HP:0000527)2.66285014
16Thin bony cortex (HP:0002753)2.56727296
17Short 4th metacarpal (HP:0010044)2.55378968
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55378968
19Pseudobulbar signs (HP:0002200)2.54690849
20Cellulitis (HP:0100658)2.52552594
21Ulnar bowing (HP:0003031)2.44888492
22Trigonocephaly (HP:0000243)2.44282477
23Renal duplication (HP:0000075)2.43923390
24Neoplasm of the oral cavity (HP:0100649)2.39784318
25Elfin facies (HP:0004428)2.39322368
26Hand muscle atrophy (HP:0009130)2.39254537
27Volvulus (HP:0002580)2.39049809
28Prominent nose (HP:0000448)2.38431943
29Increased nuchal translucency (HP:0010880)2.37922872
30Renovascular hypertension (HP:0100817)2.36793242
31Upper limb amyotrophy (HP:0009129)2.33757447
32Distal upper limb amyotrophy (HP:0007149)2.33757447
33Dislocated radial head (HP:0003083)2.31385370
34Shallow orbits (HP:0000586)2.29859328
35Abnormality of macrophages (HP:0004311)2.27275603
36Segmental peripheral demyelination/remyelination (HP:0003481)2.25325749
37Insomnia (HP:0100785)2.25214219
38Flat acetabular roof (HP:0003180)2.22954074
39Basal cell carcinoma (HP:0002671)2.22477189
40Recurrent bacterial skin infections (HP:0005406)2.22392997
41Metaphyseal cupping (HP:0003021)2.19256587
42Recurrent abscess formation (HP:0002722)2.18546406
43Abnormality of the radial head (HP:0003995)2.18174587
44Hemorrhage of the eye (HP:0011885)2.17616643
45Anal stenosis (HP:0002025)2.13867264
46Broad palm (HP:0001169)2.13047520
47Glioma (HP:0009733)2.12978079
48Supernumerary ribs (HP:0005815)2.11591382
49Inflammation of the large intestine (HP:0002037)2.08522089
50Skin tags (HP:0010609)2.08170151
51Emphysema (HP:0002097)2.08084366
52Narrow palate (HP:0000189)2.07843762
53Abnormality of the thoracic spine (HP:0100711)2.06920059
54Gastrointestinal infarctions (HP:0005244)2.06900823
55Rib fusion (HP:0000902)2.05944095
56Pointed chin (HP:0000307)2.05347431
57Broad thumb (HP:0011304)2.05055826
58Distal lower limb amyotrophy (HP:0008944)2.04886617
59Gingivitis (HP:0000230)2.04086150
60Overriding aorta (HP:0002623)2.04000042
61Malignant gastrointestinal tract tumors (HP:0006749)2.03130842
62Gastrointestinal carcinoma (HP:0002672)2.03130842
63Recurrent fungal infections (HP:0002841)2.02717357
64Myositis (HP:0100614)2.02637159
65Neoplasm of the heart (HP:0100544)2.00944604
66Neoplasm of striated muscle (HP:0009728)1.99653125
67Pustule (HP:0200039)1.98678828
68Meningitis (HP:0001287)1.98443988
69Vertebral arch anomaly (HP:0008438)1.96834443
70Abnormality of the distal phalanx of the thumb (HP:0009617)1.96643421
71Abnormality of the 4th metacarpal (HP:0010012)1.96520288
72Obstructive lung disease (HP:0006536)1.96115185
73Chronic obstructive pulmonary disease (HP:0006510)1.96115185
74Abnormal delayed hypersensitivity skin test (HP:0002963)1.93782733
75Bowel diverticulosis (HP:0005222)1.92746062
76Medulloblastoma (HP:0002885)1.92519348
77Mediastinal lymphadenopathy (HP:0100721)1.92018101
78Increased density of long bones (HP:0006392)1.91129065
79Abnormality of the columella (HP:0009929)1.90667850
80Deviation of the thumb (HP:0009603)1.90608655
81Persistence of primary teeth (HP:0006335)1.89828518
82Slow saccadic eye movements (HP:0000514)1.87755617
83Deep palmar crease (HP:0006191)1.87359824
84Obsessive-compulsive behavior (HP:0000722)1.86380869
85Proximal placement of thumb (HP:0009623)1.86280348
86Orchitis (HP:0100796)1.84507090
87Aneurysm (HP:0002617)1.83780944
88Dysmetric saccades (HP:0000641)1.83316660
89Sandal gap (HP:0001852)1.82586629
90Intestinal fistula (HP:0100819)1.81746830
91Spontaneous hematomas (HP:0007420)1.80757905
92Easy fatigability (HP:0003388)1.80676865
93Colitis (HP:0002583)1.79374335
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79296360
95Thoracic kyphosis (HP:0002942)1.79145312
96Stridor (HP:0010307)1.78600252
97Neonatal hypoglycemia (HP:0001998)1.78515179
98Onion bulb formation (HP:0003383)1.78377407
99Short phalanx of the thumb (HP:0009660)1.76926574
100Gastrointestinal stroma tumor (HP:0100723)1.76708777
101Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76340163
102Cervical subluxation (HP:0003308)1.75968924
103Mitral valve prolapse (HP:0001634)1.75423033
104Leiomyosarcoma (HP:0100243)1.74678482
105Uterine leiomyosarcoma (HP:0002891)1.74678482
106Sparse lateral eyebrow (HP:0005338)1.73635918
107Supernumerary bones of the axial skeleton (HP:0009144)1.73556357
108Cutis marmorata (HP:0000965)1.73385910
109High pitched voice (HP:0001620)1.71729293
110Polygenic inheritance (HP:0010982)1.71127645
111Disproportionate tall stature (HP:0001519)1.70856722
112Recurrent viral infections (HP:0004429)1.69128327
113Lip pit (HP:0100267)1.67508994
114Short 5th finger (HP:0009237)1.66953557
115Spina bifida occulta (HP:0003298)1.66722449
116Preauricular skin tag (HP:0000384)1.66650031
117Prolonged bleeding time (HP:0003010)1.65837703
118Germ cell neoplasia (HP:0100728)1.65705579
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.65454108
120Increased connective tissue (HP:0009025)1.65284920
121Aortic aneurysm (HP:0004942)1.65168495
122Shawl scrotum (HP:0000049)1.64851252
123Transitional cell carcinoma of the bladder (HP:0006740)1.64776787
124Hypochromic anemia (HP:0001931)1.64504745
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64416654
126Mitral regurgitation (HP:0001653)1.63604363
127Skull defect (HP:0001362)1.63433546
128Abnormality of the diencephalon (HP:0010662)1.62814554
129Nasal polyposis (HP:0100582)1.62641606
130Truncal obesity (HP:0001956)1.62513481
131Short 1st metacarpal (HP:0010034)1.62409285
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62409285
133Broad phalanges of the hand (HP:0009768)1.62388434
134Vasculitis (HP:0002633)1.61704002
135Thin ribs (HP:0000883)1.61071939
136J-shaped sella turcica (HP:0002680)1.60004380
137Recurrent cutaneous fungal infections (HP:0011370)1.59902440
138Chronic mucocutaneous candidiasis (HP:0002728)1.59902440
139Autoimmune thrombocytopenia (HP:0001973)1.59217819
140Gastrointestinal inflammation (HP:0004386)1.59148970
141Difficulty running (HP:0009046)1.59142339
142Recurrent gram-negative bacterial infections (HP:0005420)1.59003020
143Genu recurvatum (HP:0002816)1.58790256
144Turricephaly (HP:0000262)1.58604247
145Malnutrition (HP:0004395)1.58131933
146Annular pancreas (HP:0001734)1.58123778
147Depressed nasal tip (HP:0000437)1.57770778
148Flat cornea (HP:0007720)1.57726072
149Bronchomalacia (HP:0002780)1.57610625
150Fibroma (HP:0010614)1.57130000
151Rectal prolapse (HP:0002035)1.56897208
152Cafe-au-lait spot (HP:0000957)1.56561839
153Reticulocytosis (HP:0001923)1.56363650
154Seborrheic dermatitis (HP:0001051)1.55379764
155Long palpebral fissure (HP:0000637)1.55373318
156Vertebral fusion (HP:0002948)1.55341031
157Selective tooth agenesis (HP:0001592)1.55199410
158Bowel incontinence (HP:0002607)1.54818038
159Fibrous tissue neoplasm (HP:0012316)1.53786778
160Absent frontal sinuses (HP:0002688)1.53540802
161Abnormality of oral frenula (HP:0000190)1.53532210
162Abnormal vertebral ossification (HP:0100569)1.53358839
163Hypertensive crisis (HP:0100735)1.53241941
164Patellar dislocation (HP:0002999)1.53093109
165Ankyloglossia (HP:0010296)1.52757435
166Optic neuritis (HP:0100653)1.52639336
167Retrobulbar optic neuritis (HP:0100654)1.52639336
168Smooth philtrum (HP:0000319)1.52241345
169Milia (HP:0001056)1.52240662
170Recurrent skin infections (HP:0001581)1.52100777
171Hypercortisolism (HP:0001578)1.51498140
172Dysostosis multiplex (HP:0000943)1.51458665
173Abnormality of the aortic arch (HP:0012303)1.51360394
174Abnormality of the humeroradial joint (HP:0100744)1.51283973
175Abnormality of the peritoneum (HP:0002585)1.51207779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.97202649
2MAP3K103.61738768
3PRPF4B3.40295895
4EEF2K3.22587367
5TRIB33.02787874
6ICK2.94118728
7SMG12.92016867
8BRD42.38376950
9PKN22.28642153
10MAP4K12.28305507
11SIK22.03382293
12RIPK41.95912505
13ERN11.92547767
14CAMK1G1.91082682
15TYRO31.81409138
16CAMK1D1.79429826
17RIPK11.77813814
18STK101.74912059
19TNK21.66204695
20MAP3K131.64909384
21MTOR1.63236870
22NEK21.52715612
23IRAK31.51502915
24ALK1.51373245
25PTK61.50924512
26TTN1.44506045
27SIK11.43593570
28IRAK41.35044824
29PDGFRA1.34748845
30TAOK11.34484728
31GRK61.31855903
32CDC71.28445635
33MAP3K71.23276064
34CDK41.22433366
35BMX1.19965850
36LATS11.19273175
37CDK61.15027820
38MAP3K61.10754063
39SIK31.06955463
40MAP3K141.05254381
41DMPK1.01918961
42MARK21.01387313
43BLK1.00540532
44PDGFRB0.97319154
45RPS6KB20.92843534
46CDK70.92842415
47MAP3K10.92683167
48FGFR40.91419398
49CDC42BPA0.88861899
50MAP3K30.88672238
51PRKD20.88276008
52CHEK10.88127047
53TBK10.88094702
54CDK90.86564516
55CSK0.84785826
56KSR20.84481300
57MAP3K110.83813849
58JAK30.82630277
59TAOK20.82102228
60MAPK110.81643483
61PRKD30.81121864
62FGFR30.80258341
63RPS6KA20.79954666
64MAP2K30.78993264
65RPS6KL10.78706470
66RPS6KC10.78706470
67EPHB10.78592928
68PAK20.76347471
69PDPK10.75960066
70ZAP700.75859518
71LRRK20.75333442
72PRKCH0.73765653
73IRAK20.72183263
74CHUK0.70883648
75IKBKE0.70293960
76PAK40.69878422
77CAMKK10.69441920
78MAP3K90.68403754
79STK30.68132003
80HIPK20.67623673
81CDK20.67450794
82TYK20.67354962
83PTK20.67097083
84HCK0.66803541
85PIM10.66469737
86TTK0.64160779
87RET0.63914778
88MAPK120.63663910
89MAPK150.62862731
90WNK10.62512636
91FES0.62108062
92RPS6KA60.62053385
93PDK10.61974239
94CSF1R0.61499619
95JAK10.58855828
96SCYL20.58836311
97DDR20.58791733
98MAP3K80.58512655
99MAP2K20.57920867
100STK40.57637024
101MARK30.56381186
102ATR0.56225952
103MAPK70.55943965
104STK110.55804789
105ATM0.54471701
106ITK0.54325264
107SGK30.53848288
108EPHA20.52661292
109FGFR10.52613388
110DYRK1B0.49484238
111STK380.49402453
112MAPK10.48359474
113JAK20.48347857
114MAPK140.48170455
115MAP2K60.47996963
116RPS6KA10.47097258
117PAK60.46904017
118MELK0.46413275
119LATS20.46247288
120CAMK40.46031286
121MST1R0.45820558
122CSNK1D0.45249339
123CHEK20.44612820
124GSK3B0.44257270
125IRAK10.43804619
126IKBKB0.43679238
127FGR0.42845245
128SYK0.42617327
129TAOK30.42480214
130MAPK80.42349901
131CDK10.42333882
132LCK0.41408443
133PNCK0.41049478
134PRKDC0.40702299
135MAPK100.39424008
136BTK0.39173700
137TGFBR20.36911863
138MAPKAPK20.35777423

Predicted pathways (KEGG)

RankGene SetZ-score
1* Lysine degradation_Homo sapiens_hsa003102.11748322
2Notch signaling pathway_Homo sapiens_hsa043301.98541368
3Chronic myeloid leukemia_Homo sapiens_hsa052201.97971444
4Other glycan degradation_Homo sapiens_hsa005111.94114653
5mTOR signaling pathway_Homo sapiens_hsa041501.86274048
6B cell receptor signaling pathway_Homo sapiens_hsa046621.75385376
7mRNA surveillance pathway_Homo sapiens_hsa030151.71226767
8Dorso-ventral axis formation_Homo sapiens_hsa043201.63460465
9Primary immunodeficiency_Homo sapiens_hsa053401.60083828
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58430981
11Acute myeloid leukemia_Homo sapiens_hsa052211.57378494
12T cell receptor signaling pathway_Homo sapiens_hsa046601.48075630
13MicroRNAs in cancer_Homo sapiens_hsa052061.47961296
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.47636898
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45448763
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44990069
17Adherens junction_Homo sapiens_hsa045201.38684296
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38064443
19Non-small cell lung cancer_Homo sapiens_hsa052231.37618213
20Colorectal cancer_Homo sapiens_hsa052101.36016721
21Small cell lung cancer_Homo sapiens_hsa052221.35334857
22Endometrial cancer_Homo sapiens_hsa052131.34837425
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.29128353
24Proteoglycans in cancer_Homo sapiens_hsa052051.22491893
25Basal cell carcinoma_Homo sapiens_hsa052171.21444707
26Pancreatic cancer_Homo sapiens_hsa052121.21422151
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21212752
28VEGF signaling pathway_Homo sapiens_hsa043701.19633953
29Type II diabetes mellitus_Homo sapiens_hsa049301.16536865
30HTLV-I infection_Homo sapiens_hsa051661.16462151
31Hepatitis C_Homo sapiens_hsa051601.16049404
32Viral myocarditis_Homo sapiens_hsa054161.15015454
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14266061
34Insulin resistance_Homo sapiens_hsa049311.13061076
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12546023
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12093818
37Glioma_Homo sapiens_hsa052141.09718674
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09469149
39Osteoclast differentiation_Homo sapiens_hsa043801.08538022
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07697861
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07410754
42Renal cell carcinoma_Homo sapiens_hsa052111.04779975
43Hippo signaling pathway_Homo sapiens_hsa043901.04323826
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.03867269
45Tuberculosis_Homo sapiens_hsa051521.03224383
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02800219
47Prolactin signaling pathway_Homo sapiens_hsa049171.02446262
48Focal adhesion_Homo sapiens_hsa045101.01826672
49RNA transport_Homo sapiens_hsa030130.96987925
50ErbB signaling pathway_Homo sapiens_hsa040120.96220218
51Estrogen signaling pathway_Homo sapiens_hsa049150.95710367
52Toxoplasmosis_Homo sapiens_hsa051450.94907834
53Allograft rejection_Homo sapiens_hsa053300.94832541
54Platelet activation_Homo sapiens_hsa046110.92176023
55Prostate cancer_Homo sapiens_hsa052150.92100304
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.91574880
57Herpes simplex infection_Homo sapiens_hsa051680.91403867
58Choline metabolism in cancer_Homo sapiens_hsa052310.91150370
59Graft-versus-host disease_Homo sapiens_hsa053320.90608823
60Viral carcinogenesis_Homo sapiens_hsa052030.90587918
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.89228511
62Bladder cancer_Homo sapiens_hsa052190.88771316
63Staphylococcus aureus infection_Homo sapiens_hsa051500.88112184
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.88090283
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87833055
66Hepatitis B_Homo sapiens_hsa051610.87483951
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85830658
68Autoimmune thyroid disease_Homo sapiens_hsa053200.85801194
69Insulin signaling pathway_Homo sapiens_hsa049100.84568209
70Pathways in cancer_Homo sapiens_hsa052000.83596921
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83476811
72MAPK signaling pathway_Homo sapiens_hsa040100.83194855
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82348370
74AMPK signaling pathway_Homo sapiens_hsa041520.82065295
75FoxO signaling pathway_Homo sapiens_hsa040680.80438268
76Chemokine signaling pathway_Homo sapiens_hsa040620.80129950
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79500359
78Spliceosome_Homo sapiens_hsa030400.79310265
79Malaria_Homo sapiens_hsa051440.78584853
80Cell cycle_Homo sapiens_hsa041100.77982098
81Thyroid cancer_Homo sapiens_hsa052160.77426643
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77366248
83Wnt signaling pathway_Homo sapiens_hsa043100.77356988
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77013342
85Inositol phosphate metabolism_Homo sapiens_hsa005620.75421800
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.74925817
87Apoptosis_Homo sapiens_hsa042100.74729627
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74608969
89Hedgehog signaling pathway_Homo sapiens_hsa043400.74181972
90Prion diseases_Homo sapiens_hsa050200.73597862
91Antigen processing and presentation_Homo sapiens_hsa046120.73557475
92Measles_Homo sapiens_hsa051620.73248384
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.72422817
94Rap1 signaling pathway_Homo sapiens_hsa040150.71670475
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.71040350
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70815274
97Shigellosis_Homo sapiens_hsa051310.70268334
98Influenza A_Homo sapiens_hsa051640.70257837
99Leishmaniasis_Homo sapiens_hsa051400.69563720
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.68060780
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67791774
102GnRH signaling pathway_Homo sapiens_hsa049120.66227955
103Amoebiasis_Homo sapiens_hsa051460.66156846
104Long-term potentiation_Homo sapiens_hsa047200.66089336
105Fatty acid biosynthesis_Homo sapiens_hsa000610.65367121
106TGF-beta signaling pathway_Homo sapiens_hsa043500.64629724
107TNF signaling pathway_Homo sapiens_hsa046680.64203777
108HIF-1 signaling pathway_Homo sapiens_hsa040660.63440334
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63164055
110Glucagon signaling pathway_Homo sapiens_hsa049220.58339815
111Tight junction_Homo sapiens_hsa045300.57064196
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56759047
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55569266
114Endocytosis_Homo sapiens_hsa041440.55481006
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.55221379
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54941373
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54801725
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.54523218
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50951236
120Epstein-Barr virus infection_Homo sapiens_hsa051690.50304817
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50065686
122Hematopoietic cell lineage_Homo sapiens_hsa046400.49860259
123Base excision repair_Homo sapiens_hsa034100.49226912

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