KMT2D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.87178550
2positive regulation of gamma-delta T cell activation (GO:0046645)5.54820631
3positive thymic T cell selection (GO:0045059)4.88936024
4regulation of gamma-delta T cell differentiation (GO:0045586)4.72867564
5positive T cell selection (GO:0043368)4.63917476
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.63319581
7negative regulation of cell killing (GO:0031342)4.63319581
8regulation of gamma-delta T cell activation (GO:0046643)4.51867463
9* histone H3-K4 methylation (GO:0051568)4.47798933
10negative T cell selection (GO:0043383)4.42718749
11negative thymic T cell selection (GO:0045060)4.32878374
12thymic T cell selection (GO:0045061)4.14324959
13T cell selection (GO:0045058)4.14324676
14cytoplasmic mRNA processing body assembly (GO:0033962)3.99894697
15peptidyl-lysine trimethylation (GO:0018023)3.97035120
16histone H3-K36 demethylation (GO:0070544)3.77053141
173-UTR-mediated mRNA stabilization (GO:0070935)3.64665040
18positive regulation of gene expression, epigenetic (GO:0045815)3.55041410
19positive regulation of histone deacetylation (GO:0031065)3.53346750
20* histone lysine methylation (GO:0034968)3.48449950
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.47054712
22mannose metabolic process (GO:0006013)3.35704503
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.35682807
24negative regulation of translation, ncRNA-mediated (GO:0040033)3.35682807
25regulation of translation, ncRNA-mediated (GO:0045974)3.35682807
26pre-miRNA processing (GO:0031054)3.34765913
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.30324791
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30324791
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28648444
30interferon-gamma production (GO:0032609)3.22117941
31antigen processing and presentation of endogenous antigen (GO:0019883)3.20102568
32glucocorticoid receptor signaling pathway (GO:0042921)3.16307341
33response to interleukin-15 (GO:0070672)3.14156055
34negative regulation of myotube differentiation (GO:0010832)3.08913831
35RNA stabilization (GO:0043489)3.08344932
36mRNA stabilization (GO:0048255)3.08344932
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06020087
38peptidyl-lysine methylation (GO:0018022)3.04493505
39positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.03926549
40B cell receptor signaling pathway (GO:0050853)3.01084425
41adherens junction assembly (GO:0034333)2.98031083
42positive regulation of CREB transcription factor activity (GO:0032793)2.94632368
43corticosteroid receptor signaling pathway (GO:0031958)2.94155226
44regulation of T cell tolerance induction (GO:0002664)2.93652172
45negative regulation of cell size (GO:0045792)2.92655460
46histone H4-K16 acetylation (GO:0043984)2.90215057
47regulation of NFAT protein import into nucleus (GO:0051532)2.89990184
48response to muramyl dipeptide (GO:0032495)2.89957868
49cytoskeletal anchoring at plasma membrane (GO:0007016)2.89767837
50regulation of B cell differentiation (GO:0045577)2.88999549
51histone lysine demethylation (GO:0070076)2.87456819
52focal adhesion assembly (GO:0048041)2.87090503
53cell-substrate adherens junction assembly (GO:0007045)2.87090503
54positive regulation of granulocyte differentiation (GO:0030854)2.86910327
55regulation of B cell receptor signaling pathway (GO:0050855)2.86890684
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86705460
57positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84780238
58positive regulation of B cell differentiation (GO:0045579)2.83362119
59response to laminar fluid shear stress (GO:0034616)2.81486430
60mitotic sister chromatid cohesion (GO:0007064)2.78704450
61tolerance induction (GO:0002507)2.76755985
62negative regulation of erythrocyte differentiation (GO:0045647)2.75654336
63* histone methylation (GO:0016571)2.75261620
64negative regulation of granulocyte differentiation (GO:0030853)2.75100589
65nuclear pore complex assembly (GO:0051292)2.74951476
66regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.74470147
67positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.74470147
68negative regulation of histone methylation (GO:0031061)2.74416082
69embryonic process involved in female pregnancy (GO:0060136)2.73892796
70regulation of RNA export from nucleus (GO:0046831)2.73827517
71histone demethylation (GO:0016577)2.73171468
72regulation of ARF GTPase activity (GO:0032312)2.71229972
73histone H3-K9 demethylation (GO:0033169)2.69999348
74positive regulation of mRNA catabolic process (GO:0061014)2.68117369
75intracellular estrogen receptor signaling pathway (GO:0030520)2.66585911
76T cell receptor signaling pathway (GO:0050852)2.66518447
77regulation of mRNA catabolic process (GO:0061013)2.66132932
78histone H3-K9 methylation (GO:0051567)2.65643362
79regulation of granulocyte differentiation (GO:0030852)2.64953576
80histone H3-K9 modification (GO:0061647)2.64952443
81positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64146198
82regulation of protein deacetylation (GO:0090311)2.63763410
83peptidyl-threonine phosphorylation (GO:0018107)2.62927357
84embryonic hemopoiesis (GO:0035162)2.61978075
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61487676
86antigen receptor-mediated signaling pathway (GO:0050851)2.61044311
87T cell migration (GO:0072678)2.59424505
88NLS-bearing protein import into nucleus (GO:0006607)2.58142619
89definitive hemopoiesis (GO:0060216)2.57242364
90regulation of histone deacetylation (GO:0031063)2.56068441
91regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.56057730
92positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.56057730
93regulation of histone H3-K27 methylation (GO:0061085)2.55469747
94regulation of histone H3-K4 methylation (GO:0051569)2.55463258
95leukocyte aggregation (GO:0070486)2.53937495
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.53881839
97regulation of nucleobase-containing compound transport (GO:0032239)2.53247776
98negative regulation of glial cell proliferation (GO:0060253)2.52355770
99cellular response to interleukin-15 (GO:0071350)2.51158702
100histone H4 acetylation (GO:0043967)2.51071101
101apoptotic process involved in morphogenesis (GO:0060561)2.50012907
102positive regulation of interleukin-2 production (GO:0032743)2.49554902
103positive regulation of protein deacetylation (GO:0090312)2.48496858
104embryonic camera-type eye morphogenesis (GO:0048596)2.47824948
105protein dealkylation (GO:0008214)2.47636647
106protein demethylation (GO:0006482)2.47636647
107stress granule assembly (GO:0034063)2.45943040
108negative regulation of fatty acid transport (GO:2000192)2.45384464
109cell-substrate junction assembly (GO:0007044)2.45147941
110endothelial cell chemotaxis (GO:0035767)2.44558247
111megakaryocyte development (GO:0035855)2.44186321
112negative regulation of stress fiber assembly (GO:0051497)2.42860221
113B cell homeostasis (GO:0001782)2.42454375
114regulation of alpha-beta T cell proliferation (GO:0046640)2.42190077
115peptidyl-threonine modification (GO:0018210)2.41796143
116positive regulation of tolerance induction (GO:0002645)2.38312695
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.36576268
118hypotonic response (GO:0006971)2.35747443
119T cell costimulation (GO:0031295)2.35628818
120N-terminal protein amino acid acetylation (GO:0006474)2.34507298
121regulation of interleukin-2 biosynthetic process (GO:0045076)2.34242722
122negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.33955412
123embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33874544
124positive regulation of Rap GTPase activity (GO:0032854)2.33841688
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.33282717
126histone mRNA catabolic process (GO:0071044)2.33043019
127modulation by symbiont of host cellular process (GO:0044068)2.32823564
128embryonic eye morphogenesis (GO:0048048)2.32508976
129lymphocyte homeostasis (GO:0002260)2.31259913
130NIK/NF-kappaB signaling (GO:0038061)2.31165129
131regulation of ARF protein signal transduction (GO:0032012)2.30765379
132regulation of monocyte differentiation (GO:0045655)2.30248806
133lymphocyte costimulation (GO:0031294)2.29748890
134histone acetylation (GO:0016573)2.29471205
135negative regulation of vascular permeability (GO:0043116)2.29344195
136modulation by symbiont of host immune response (GO:0052553)2.29168812
137positive regulation by symbiont of host defense response (GO:0052509)2.29168812
138modulation by symbiont of host defense response (GO:0052031)2.29168812
139modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29168812
140modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.29168812
141positive regulation by organism of defense response of other organism involved in symbiotic interact2.29168812
142positive regulation of isotype switching (GO:0045830)2.28623924
143activation of JUN kinase activity (GO:0007257)2.28393589
144activated T cell proliferation (GO:0050798)2.28252958
145histone deubiquitination (GO:0016578)2.27202438
146positive regulation by host of viral transcription (GO:0043923)2.26231691
147activation of Rac GTPase activity (GO:0032863)2.25969239
148negative regulation of histone modification (GO:0031057)2.25948522
149regulation of fatty acid beta-oxidation (GO:0031998)2.24725155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.97366432
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33932753
3MYC_22102868_ChIP-Seq_BL_Human3.94106684
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.45625834
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26797386
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.14179154
7E2F7_22180533_ChIP-Seq_HELA_Human2.92345060
8VDR_21846776_ChIP-Seq_THP-1_Human2.84329983
9TCF7_22412390_ChIP-Seq_EML_Mouse2.83994195
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.83216348
11RUNX_20019798_ChIP-Seq_JUKART_Human2.73883268
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.64689477
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.60315647
14KDM2B_26808549_Chip-Seq_DND41_Human2.52053513
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.46386479
16SCL_19346495_ChIP-Seq_HPC-7_Human2.44832811
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44744980
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33462292
19LXR_22292898_ChIP-Seq_THP-1_Human2.31765116
20MAF_26560356_Chip-Seq_TH1_Human2.29112743
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27438183
22UTX_26944678_Chip-Seq_JUKART_Human2.26624413
23MYB_26560356_Chip-Seq_TH1_Human2.17639615
24SPI1_23127762_ChIP-Seq_K562_Human2.12183650
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08909642
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.05799920
27MYB_26560356_Chip-Seq_TH2_Human2.04176498
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02124560
29CIITA_25753668_ChIP-Seq_RAJI_Human1.99721211
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96515035
31VDR_24763502_ChIP-Seq_THP-1_Human1.94938132
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92211963
33RACK7_27058665_Chip-Seq_MCF-7_Human1.82382153
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.81008754
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.79586249
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78744537
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77509932
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72823586
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69277239
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.67992351
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.60546138
42EZH2_22144423_ChIP-Seq_EOC_Human1.59796831
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.58025506
44SMC4_20622854_ChIP-Seq_HELA_Human1.56851848
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54200878
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53648519
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.51263104
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51262737
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.50875595
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.50610811
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49660767
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44736889
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.44059656
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43708087
55MAF_26560356_Chip-Seq_TH2_Human1.41544398
56CREB1_26743006_Chip-Seq_LNCaP_Human1.40035106
57GATA3_27048872_Chip-Seq_THYMUS_Human1.39591911
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.37084526
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34760061
60KDM2B_26808549_Chip-Seq_K562_Human1.33779823
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31531033
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31351267
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31213526
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.29849596
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29729028
66P68_20966046_ChIP-Seq_HELA_Human1.28968672
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28937475
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25658495
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23646706
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.23278221
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21956417
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21649635
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21342435
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20291205
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19940321
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19523051
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.18297884
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18235592
79NCOR1_26117541_ChIP-Seq_K562_Human1.18234545
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.16260297
81PU_27001747_Chip-Seq_BMDM_Mouse1.15564676
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15302790
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14795266
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14323670
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13719671
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12749866
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11928589
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11325687
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10705810
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.10113682
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.10020879
92GATA1_19941826_ChIP-Seq_K562_Human1.08018867
93DROSHA_22980978_ChIP-Seq_HELA_Human1.07762625
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07130518
95SPI1_23547873_ChIP-Seq_NB4_Human1.05091156
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02403982
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01549938
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00915235
99RUNX1_27514584_Chip-Seq_MCF-7_Human0.99952604
100GATA1_22025678_ChIP-Seq_K562_Human0.99257497
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98934303
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98694712
103VDR_24787735_ChIP-Seq_THP-1_Human0.98553433
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97858174
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97580087
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96428634
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95957306
108TP53_22127205_ChIP-Seq_IMR90_Human0.95698020
109GATA2_19941826_ChIP-Seq_K562_Human0.94871669
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94252201
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94112204
112FOXA2_19822575_ChIP-Seq_HepG2_Human0.93774479
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93699699
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92037382
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91599509
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91285869
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90198375
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89910947
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89657621
120KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89637502
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89506055
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88986767
123TP63_22573176_ChIP-Seq_HFKS_Human0.88953658
124AHR_22903824_ChIP-Seq_MCF-7_Human0.88915494
125ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86419403
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.85955132
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.84305395
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.84305395
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.82990285
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.82916814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.77658105
2MP0003763_abnormal_thymus_physiology3.42515452
3MP0002396_abnormal_hematopoietic_system2.96760603
4MP0002166_altered_tumor_susceptibility2.91162643
5MP0004233_abnormal_muscle_weight2.85373655
6MP0009278_abnormal_bone_marrow2.75326270
7MP0004808_abnormal_hematopoietic_stem2.62027646
8MP0005076_abnormal_cell_differentiation2.58275470
9MP0001800_abnormal_humoral_immune2.50223641
10MP0003300_gastrointestinal_ulcer2.48095232
11MP0005451_abnormal_body_composition2.47661889
12MP0004858_abnormal_nervous_system2.42037528
13MP0005387_immune_system_phenotype2.40262215
14MP0001790_abnormal_immune_system2.40262215
15MP0008961_abnormal_basal_metabolism2.37456358
16MP0001835_abnormal_antigen_presentation2.32458415
17MP0003787_abnormal_imprinting2.24601093
18MP0002006_tumorigenesis2.18537989
19MP0002398_abnormal_bone_marrow2.18482920
20MP0005671_abnormal_response_to2.15032969
21MP0000703_abnormal_thymus_morphology2.12823479
22MP0004510_myositis2.09643193
23MP0000685_abnormal_immune_system2.09320927
24MP0005174_abnormal_tail_pigmentation2.05262331
25MP0003303_peritoneal_inflammation1.96382440
26MP0003045_fibrosis1.94708615
27MP0005397_hematopoietic_system_phenotyp1.93199553
28MP0001545_abnormal_hematopoietic_system1.93199553
29MP0002452_abnormal_antigen_presenting1.90069168
30MP0001873_stomach_inflammation1.88663612
31MP0002420_abnormal_adaptive_immunity1.86753667
32MP0001819_abnormal_immune_cell1.83830659
33MP0003646_muscle_fatigue1.79009955
34MP0002723_abnormal_immune_serum1.78917061
35MP0000716_abnormal_immune_system1.75483537
36MP0004381_abnormal_hair_follicle1.71250570
37MP0000566_synostosis1.67850034
38MP0002722_abnormal_immune_system1.67559905
39MP0000689_abnormal_spleen_morphology1.65720038
40MP0010352_gastrointestinal_tract_polyps1.64978116
41MP0003866_abnormal_defecation1.61826907
42MP0002405_respiratory_system_inflammati1.58288904
43MP0003183_abnormal_peptide_metabolism1.56851527
44MP0005000_abnormal_immune_tolerance1.56191929
45MP0004947_skin_inflammation1.50649718
46MP0008260_abnormal_autophagy1.49763317
47MP0005670_abnormal_white_adipose1.47152771
48MP0000015_abnormal_ear_pigmentation1.44872197
49MP0010368_abnormal_lymphatic_system1.43392159
50MP0004130_abnormal_muscle_cell1.42018232
51MP0010307_abnormal_tumor_latency1.40379832
52MP0002429_abnormal_blood_cell1.40077848
53MP0010155_abnormal_intestine_physiology1.35249082
54MP0009333_abnormal_splenocyte_physiolog1.34894603
55MP0002249_abnormal_larynx_morphology1.34882630
56MP0003436_decreased_susceptibility_to1.32226305
57MP0001348_abnormal_lacrimal_gland1.26669548
58MP0008057_abnormal_DNA_replication1.24860266
59MP0005464_abnormal_platelet_physiology1.23447570
60MP0002928_abnormal_bile_duct1.20543003
61MP0005025_abnormal_response_to1.18537516
62MP0005666_abnormal_adipose_tissue1.17300968
63MP0005310_abnormal_salivary_gland1.17108308
64MP0002009_preneoplasia1.16259042
65MP0002419_abnormal_innate_immunity1.16228851
66MP0010630_abnormal_cardiac_muscle1.15403351
67MP0003172_abnormal_lysosome_physiology1.14430621
68MP0003566_abnormal_cell_adhesion1.11001696
69MP0000733_abnormal_muscle_development1.09555104
70MP0003091_abnormal_cell_migration1.07636266
71MP0006138_congestive_heart_failure1.07599157
72MP0000371_diluted_coat_color1.05188624
73MP0002925_abnormal_cardiovascular_devel1.02249174
74MP0004264_abnormal_extraembryonic_tissu1.01982546
75MP0009672_abnormal_birth_weight1.01868813
76MP0000465_gastrointestinal_hemorrhage1.01544953
77MP0003984_embryonic_growth_retardation0.98166170
78MP0008877_abnormal_DNA_methylation0.97271881
79MP0002088_abnormal_embryonic_growth/wei0.95159917
80MP0003828_pulmonary_edema0.94024616
81MP0003453_abnormal_keratinocyte_physiol0.93403424
82MP0004036_abnormal_muscle_relaxation0.92131703
83MP0005409_darkened_coat_color0.90786210
84MP0001915_intracranial_hemorrhage0.90471690
85MP0003279_aneurysm0.89735285
86MP0000470_abnormal_stomach_morphology0.88624557
87MP0002089_abnormal_postnatal_growth/wei0.88344677
88MP0003115_abnormal_respiratory_system0.87957452
89MP0003943_abnormal_hepatobiliary_system0.87386766
90MP0005058_abnormal_lysosome_morphology0.86922380
91MP0000350_abnormal_cell_proliferation0.86659749
92MP0003077_abnormal_cell_cycle0.86309268
93MP0005167_abnormal_blood-brain_barrier0.86084400
94MP0000678_abnormal_parathyroid_gland0.85289907
95MP0000266_abnormal_heart_morphology0.85276644
96MP0000858_altered_metastatic_potential0.84771203
97MP0005645_abnormal_hypothalamus_physiol0.84742892
98MP0005380_embryogenesis_phenotype0.83151355
99MP0001672_abnormal_embryogenesis/_devel0.83151355
100MP0003705_abnormal_hypodermis_morpholog0.83120709
101MP0000767_abnormal_smooth_muscle0.82768011
102MP0001845_abnormal_inflammatory_respons0.82688415
103MP0005075_abnormal_melanosome_morpholog0.82679391
104MP0005023_abnormal_wound_healing0.81591802
105MP0004043_abnormal_pH_regulation0.79734268
106MP0001849_ear_inflammation0.79632677
107MP0000003_abnormal_adipose_tissue0.79546673
108MP0002970_abnormal_white_adipose0.79160895
109MP0000759_abnormal_skeletal_muscle0.78588602
110MP0003121_genomic_imprinting0.78028629
111MP0000490_abnormal_crypts_of0.77010545
112MP0001533_abnormal_skeleton_physiology0.76607355
113MP0004084_abnormal_cardiac_muscle0.76288192
114MP0002086_abnormal_extraembryonic_tissu0.75977736
115MP0005621_abnormal_cell_physiology0.74487830
116MP0004185_abnormal_adipocyte_glucose0.73967660
117MP0002933_joint_inflammation0.73894527
118MP0002168_other_aberrant_phenotype0.73412247
119MP0001784_abnormal_fluid_regulation0.73266452
120MP0003111_abnormal_nucleus_morphology0.72845404
121MP0002019_abnormal_tumor_incidence0.72761357
122MP0004087_abnormal_muscle_fiber0.72349334
123MP0002075_abnormal_coat/hair_pigmentati0.71968868
124MP0002998_abnormal_bone_remodeling0.70955730
125MP0001853_heart_inflammation0.69623626
126MP0005375_adipose_tissue_phenotype0.68646599
127MP0001851_eye_inflammation0.67810417
128MP0009115_abnormal_fat_cell0.66556135
129MP0004197_abnormal_fetal_growth/weight/0.66205839
130MP0002095_abnormal_skin_pigmentation0.65798515
131MP0003448_altered_tumor_morphology0.65076833

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of the fingertips (HP:0001211)4.48656146
2Obstructive sleep apnea (HP:0002870)4.42309522
3Broad face (HP:0000283)3.94620251
4Urethral obstruction (HP:0000796)3.86175820
5Long eyelashes (HP:0000527)3.83310625
6T lymphocytopenia (HP:0005403)3.19019105
7Macroorchidism (HP:0000053)3.13373949
8Recurrent viral infections (HP:0004429)3.11049831
9Narrow palate (HP:0000189)3.10069161
10Panhypogammaglobulinemia (HP:0003139)3.00089274
11Abnormality of T cell number (HP:0011839)2.96145205
12Agammaglobulinemia (HP:0004432)2.92781165
13Recurrent fungal infections (HP:0002841)2.92090366
14Abnormal delayed hypersensitivity skin test (HP:0002963)2.89524242
15Trigonocephaly (HP:0000243)2.69946807
16Thyroiditis (HP:0100646)2.64867644
17Cerebral aneurysm (HP:0004944)2.64851672
18Abnormality of the distal phalanx of the thumb (HP:0009617)2.60811210
19Flat acetabular roof (HP:0003180)2.58792838
20Short 4th metacarpal (HP:0010044)2.55643641
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55643641
22Disproportionate tall stature (HP:0001519)2.49076102
23Prominent nose (HP:0000448)2.46816501
24Colitis (HP:0002583)2.45081863
25Hyperacusis (HP:0010780)2.44899261
26Spinal cord lesions (HP:0100561)2.40978820
27Syringomyelia (HP:0003396)2.40978820
28Recurrent cutaneous fungal infections (HP:0011370)2.40096714
29Chronic mucocutaneous candidiasis (HP:0002728)2.40096714
30Absent frontal sinuses (HP:0002688)2.39564214
31Acute myeloid leukemia (HP:0004808)2.37460561
32Volvulus (HP:0002580)2.31325679
33Periodontitis (HP:0000704)2.30080795
34Inflammation of the large intestine (HP:0002037)2.25969210
35Severe combined immunodeficiency (HP:0004430)2.24162173
36Heterotopia (HP:0002282)2.23815226
37Persistence of primary teeth (HP:0006335)2.23497756
38Cellulitis (HP:0100658)2.23448557
39Gastrointestinal inflammation (HP:0004386)2.21612797
40Abnormality of B cell number (HP:0010975)2.20572734
41B lymphocytopenia (HP:0010976)2.20572734
42Self-mutilation (HP:0000742)2.17914746
43Asymmetry of the thorax (HP:0001555)2.16550780
44Advanced eruption of teeth (HP:0006288)2.11121888
45Shallow orbits (HP:0000586)2.09948736
46Eosinophilia (HP:0001880)2.08748489
47Papilloma (HP:0012740)2.07181377
48Verrucae (HP:0200043)2.07181377
49Abnormality of the columella (HP:0009929)2.05115411
50Vertebral arch anomaly (HP:0008438)2.04568577
51Genetic anticipation (HP:0003743)2.01208152
52Truncal obesity (HP:0001956)2.01157212
53Increased connective tissue (HP:0009025)1.99185145
54Germ cell neoplasia (HP:0100728)1.98593032
55Abnormality of T cells (HP:0002843)1.98556716
56Neonatal hypoglycemia (HP:0001998)1.98478652
57Dysmetric saccades (HP:0000641)1.97014203
58Aortic aneurysm (HP:0004942)1.96526664
59Ulnar bowing (HP:0003031)1.96320730
60Acute lymphatic leukemia (HP:0006721)1.96096050
61Combined immunodeficiency (HP:0005387)1.95537960
62Dislocated radial head (HP:0003083)1.95452611
63Abnormality of the nasal septum (HP:0000419)1.95421368
64Limited elbow extension (HP:0001377)1.95081257
65Natal tooth (HP:0000695)1.94525924
66Abnormality of the thoracic spine (HP:0100711)1.92946581
67IgM deficiency (HP:0002850)1.91973002
68Deep philtrum (HP:0002002)1.90793713
69Meningitis (HP:0001287)1.90618014
70Recurrent bronchitis (HP:0002837)1.89705990
71Thin bony cortex (HP:0002753)1.89602515
72Abnormality of the phalanges of the hallux (HP:0010057)1.89400462
73Broad palm (HP:0001169)1.89238320
74Pustule (HP:0200039)1.85527099
75Thick eyebrow (HP:0000574)1.85357745
76Abnormality of the radial head (HP:0003995)1.84524251
77Hemorrhage of the eye (HP:0011885)1.83043022
78Abnormality of eosinophils (HP:0001879)1.82738456
79Sandal gap (HP:0001852)1.82013756
80Abnormality of the intervertebral disk (HP:0005108)1.81893402
81Lymphopenia (HP:0001888)1.81588707
82Obsessive-compulsive behavior (HP:0000722)1.80584972
83Eczematoid dermatitis (HP:0000976)1.80549286
84Leukocytosis (HP:0001974)1.79965239
85Thoracic kyphosis (HP:0002942)1.79138784
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.78253842
87Onion bulb formation (HP:0003383)1.78236929
88Supernumerary ribs (HP:0005815)1.76117747
89Abnormality of the humeroradial joint (HP:0100744)1.75468415
90Prolonged bleeding time (HP:0003010)1.75311480
91Mitral valve prolapse (HP:0001634)1.75161581
92Subacute progressive viral hepatitis (HP:0006572)1.74057951
93Spondylolisthesis (HP:0003302)1.73823920
94Chest pain (HP:0100749)1.73137559
95Distal lower limb amyotrophy (HP:0008944)1.73079876
96Mediastinal lymphadenopathy (HP:0100721)1.72842432
97Broad thumb (HP:0011304)1.72301188
98Annular pancreas (HP:0001734)1.71931597
99Overgrowth (HP:0001548)1.71405161
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.71277827
101Pigmentary retinal degeneration (HP:0001146)1.70917042
102Low anterior hairline (HP:0000294)1.70727484
103Slow saccadic eye movements (HP:0000514)1.70105527
104Recurrent abscess formation (HP:0002722)1.70049738
105Increased IgE level (HP:0003212)1.68808183
106Congenital stationary night blindness (HP:0007642)1.68777709
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68185054
108Abnormal hair whorl (HP:0010721)1.67418352
109Chronic diarrhea (HP:0002028)1.66769291
110Emphysema (HP:0002097)1.66265311
111Smooth philtrum (HP:0000319)1.65439293
112Cutis marmorata (HP:0000965)1.64537621
113Laryngomalacia (HP:0001601)1.63819652
114Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.63764762
115Aneurysm (HP:0002617)1.63319127
116Renal cell carcinoma (HP:0005584)1.63259319
117Pointed chin (HP:0000307)1.62871976
118Chronic otitis media (HP:0000389)1.62663639
119Granulocytopenia (HP:0001913)1.62484938
120Urinary glycosaminoglycan excretion (HP:0003541)1.62463394
121Mucopolysacchariduria (HP:0008155)1.62463394
122Viral hepatitis (HP:0006562)1.62204174
123Bicuspid aortic valve (HP:0001647)1.61439724
124Abnormality of the aortic arch (HP:0012303)1.61139443
125Abnormality of the epiphyses of the hand (HP:0005924)1.59664960
126Segmental peripheral demyelination/remyelination (HP:0003481)1.59615205
127IgA deficiency (HP:0002720)1.58741331
128Abnormality of the 4th metacarpal (HP:0010012)1.58314167
129Abnormality of the distal phalanges of the toes (HP:0010182)1.58234126
130Underdeveloped nasal alae (HP:0000430)1.58159414
131Progressive hearing impairment (HP:0001730)1.57992748
132Recurrent bacterial skin infections (HP:0005406)1.57991483
133Ankyloglossia (HP:0010296)1.57646351
134Gingivitis (HP:0000230)1.57518046
135Elfin facies (HP:0004428)1.57157403
136Tapered finger (HP:0001182)1.56935428
137Hematochezia (HP:0002573)1.56857583
138Neoplasm of the oral cavity (HP:0100649)1.56285148
139Oligodontia (HP:0000677)1.55839258
140Aqueductal stenosis (HP:0002410)1.55764651
141Vasculitis (HP:0002633)1.55749809
142Spontaneous hematomas (HP:0007420)1.55518216
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.54013869
144Supernumerary bones of the axial skeleton (HP:0009144)1.53800124
145Metaphyseal cupping (HP:0003021)1.53793316
146Broad phalanges of the hand (HP:0009768)1.53568276
147Stereotypic behavior (HP:0000733)1.53216205
148Broad hallux (HP:0010055)1.52019789
149Bronchomalacia (HP:0002780)1.51402538
150Neoplasm of the heart (HP:0100544)1.51142624
151Thin ribs (HP:0000883)1.51095323
152Broad finger (HP:0001500)1.47540230
153Coarse hair (HP:0002208)1.45859912
154Supernumerary nipples (HP:0002558)1.45253704
155Plagiocephaly (HP:0001357)1.44388797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.69311753
2MAP4K13.79784903
3MAP3K102.75145824
4CAMK1G2.68772825
5BRD42.61026582
6CAMK1D2.60708921
7SIK22.48173359
8SMG12.43888692
9TXK2.19514824
10LATS12.02207348
11EEF2K2.00527770
12JAK31.97459843
13JAK11.70358363
14FGFR31.64423618
15TYK21.58266157
16TAOK31.57077970
17SIK11.55570214
18MAP3K31.49041143
19SGK31.48919395
20SIK31.48712119
21STK101.41932241
22TTN1.39743228
23MAP3K71.38892147
24MAP3K141.38350975
25ITK1.37505741
26CHUK1.36781435
27ERN11.35768518
28STK241.33835288
29TAOK11.33697167
30ZAP701.32467523
31MAP2K31.30772635
32MARK21.30494730
33SGK21.29819228
34MAP3K131.29031632
35MTOR1.28783384
36MAP3K21.26151889
37HCK1.25319694
38BLK1.24433642
39PRKCH1.23324453
40DMPK1.22089992
41PRKD21.21319066
42IKBKE1.19489073
43FGFR41.18222676
44TRIB31.17442696
45PRPF4B1.09191106
46CLK11.08637114
47PDGFRB1.05212381
48GRK61.04337005
49BTK1.04195720
50CDC42BPA1.00264451
51CDK90.99630157
52HIPK20.95791156
53RIPK10.92875400
54STK380.92381974
55LCK0.91716384
56NLK0.91502107
57KIT0.91132260
58PTK60.91118776
59SYK0.90415445
60CAMK40.90011497
61STK40.88077779
62MAPK110.85325172
63CSF1R0.85273116
64ICK0.85072688
65PKN20.84961249
66CSK0.84623214
67MARK30.84492943
68WNK10.82614670
69MAPK70.81906925
70CDK40.79679531
71PIM10.78235341
72CDK60.77344470
73STK30.77032797
74NEK20.77004487
75CAMKK10.76556198
76MELK0.72491810
77EPHB10.70155804
78IKBKB0.69834947
79RET0.68003239
80MAPK120.67719113
81PDPK10.67659213
82KSR20.67507781
83FES0.67400666
84TRPM70.65530656
85JAK20.65520054
86TGFBR20.65194505
87NUAK10.64738766
88MAP3K10.63826686
89IRAK30.61191691
90TEC0.60757628
91TNK20.60689670
92TYRO30.59765519
93IRAK40.59152159
94ALK0.58815568
95WNK40.58622145
96PDK10.57782236
97PRKAA20.57228942
98ATR0.55705935
99SGK4940.54293181
100SGK2230.54293181
101RPS6KB20.52301970
102ATM0.52273793
103NTRK20.52064619
104SGK10.52039677
105CHEK10.51454592
106MAP3K90.50867680
107RIPK40.47800175
108PDGFRA0.47468728
109MAPK140.47400590
110FGFR20.46684019
111EPHA30.46662204
112MKNK20.45990073
113MAPKAPK30.44331598
114MAPK100.43752899
115YES10.43634624
116PRKAA10.43465790
117BMX0.43289570
118AKT30.43042988
119RPS6KC10.42863195
120RPS6KL10.42863195
121IRAK20.42631206
122CDK70.42546436
123RPS6KA60.42478731
124MAPK80.42447039
125CAMK10.41950256
126MAPK10.41775693
127RPS6KA20.41278207
128MAP3K60.35876643

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.80758363
2B cell receptor signaling pathway_Homo sapiens_hsa046622.08864958
3* Lysine degradation_Homo sapiens_hsa003101.94196187
4T cell receptor signaling pathway_Homo sapiens_hsa046601.91602726
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.72711439
6Notch signaling pathway_Homo sapiens_hsa043301.63339931
7Acute myeloid leukemia_Homo sapiens_hsa052211.61093713
8Chronic myeloid leukemia_Homo sapiens_hsa052201.60104506
9Osteoclast differentiation_Homo sapiens_hsa043801.59404538
10Measles_Homo sapiens_hsa051621.55748380
11Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42679520
12Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41154538
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37140728
14Type II diabetes mellitus_Homo sapiens_hsa049301.36384609
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36047388
16Other glycan degradation_Homo sapiens_hsa005111.31957644
17Viral myocarditis_Homo sapiens_hsa054161.30689214
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29927558
19Leishmaniasis_Homo sapiens_hsa051401.28275498
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.27795425
21Hematopoietic cell lineage_Homo sapiens_hsa046401.27285154
22Herpes simplex infection_Homo sapiens_hsa051681.27103549
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.26751100
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25827423
25mTOR signaling pathway_Homo sapiens_hsa041501.24642578
26Chemokine signaling pathway_Homo sapiens_hsa040621.22835607
27Pancreatic cancer_Homo sapiens_hsa052121.19409922
28Non-small cell lung cancer_Homo sapiens_hsa052231.19131401
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18064275
30Hepatitis B_Homo sapiens_hsa051611.17735335
31Influenza A_Homo sapiens_hsa051641.17125577
32Endometrial cancer_Homo sapiens_hsa052131.14670816
33Toxoplasmosis_Homo sapiens_hsa051451.14077750
34AMPK signaling pathway_Homo sapiens_hsa041521.13833983
35MicroRNAs in cancer_Homo sapiens_hsa052061.13150699
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.12896965
37Small cell lung cancer_Homo sapiens_hsa052221.08088478
38Insulin resistance_Homo sapiens_hsa049311.06531367
39Phototransduction_Homo sapiens_hsa047441.06439736
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06227442
41Platelet activation_Homo sapiens_hsa046111.05084286
42Long-term potentiation_Homo sapiens_hsa047201.03083473
43HTLV-I infection_Homo sapiens_hsa051661.03030581
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03025682
45Adherens junction_Homo sapiens_hsa045201.02722035
46Colorectal cancer_Homo sapiens_hsa052101.01658966
47Prolactin signaling pathway_Homo sapiens_hsa049171.01576274
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99498610
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98636821
50Inositol phosphate metabolism_Homo sapiens_hsa005620.98608431
51Prostate cancer_Homo sapiens_hsa052150.97770810
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97519665
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.97218378
54Bladder cancer_Homo sapiens_hsa052190.94527469
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93867131
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92898604
57TNF signaling pathway_Homo sapiens_hsa046680.92208035
58FoxO signaling pathway_Homo sapiens_hsa040680.88147147
59Antigen processing and presentation_Homo sapiens_hsa046120.87644302
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85865920
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85823807
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.84882052
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84515855
64Proteoglycans in cancer_Homo sapiens_hsa052050.82852474
65mRNA surveillance pathway_Homo sapiens_hsa030150.82698736
66Glioma_Homo sapiens_hsa052140.81740074
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79550191
68ErbB signaling pathway_Homo sapiens_hsa040120.78879223
69Apoptosis_Homo sapiens_hsa042100.78805205
70MAPK signaling pathway_Homo sapiens_hsa040100.78604909
71Choline metabolism in cancer_Homo sapiens_hsa052310.77397998
72Dilated cardiomyopathy_Homo sapiens_hsa054140.75936568
73Amoebiasis_Homo sapiens_hsa051460.75614271
74Tuberculosis_Homo sapiens_hsa051520.75011331
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74513955
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.73527678
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72730892
78Renal cell carcinoma_Homo sapiens_hsa052110.72724421
79Non-homologous end-joining_Homo sapiens_hsa034500.72388454
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.72036021
81Hepatitis C_Homo sapiens_hsa051600.71647133
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71392123
83Cholinergic synapse_Homo sapiens_hsa047250.70792270
84Viral carcinogenesis_Homo sapiens_hsa052030.69819679
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69452105
86Insulin signaling pathway_Homo sapiens_hsa049100.68985972
87Pathways in cancer_Homo sapiens_hsa052000.68852443
88Focal adhesion_Homo sapiens_hsa045100.67698027
89VEGF signaling pathway_Homo sapiens_hsa043700.67199962
90Melanogenesis_Homo sapiens_hsa049160.66768432
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66433325
92Oxytocin signaling pathway_Homo sapiens_hsa049210.65824361
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65623327
94Rap1 signaling pathway_Homo sapiens_hsa040150.64798156
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63129864
96HIF-1 signaling pathway_Homo sapiens_hsa040660.63003478
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.61489982
98Thyroid cancer_Homo sapiens_hsa052160.61356479
99ABC transporters_Homo sapiens_hsa020100.59525960
100Epstein-Barr virus infection_Homo sapiens_hsa051690.59484860
101Endocytosis_Homo sapiens_hsa041440.56750494
102cAMP signaling pathway_Homo sapiens_hsa040240.56295867
103Estrogen signaling pathway_Homo sapiens_hsa049150.56016026
104Circadian rhythm_Homo sapiens_hsa047100.55568283
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54338459
106Malaria_Homo sapiens_hsa051440.53605068
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52946050
108Fatty acid biosynthesis_Homo sapiens_hsa000610.52791264
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52668767
110Gastric acid secretion_Homo sapiens_hsa049710.51926744
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51048943
112GnRH signaling pathway_Homo sapiens_hsa049120.50681447
113Wnt signaling pathway_Homo sapiens_hsa043100.50645446
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50626521
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50387390
116Glucagon signaling pathway_Homo sapiens_hsa049220.49499776
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.49470934
118Thyroid hormone synthesis_Homo sapiens_hsa049180.48865922
119Long-term depression_Homo sapiens_hsa047300.48373465

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