KMT2E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.10248825
2histone H3-K4 trimethylation (GO:0080182)4.55225224
3neural tube formation (GO:0001841)4.42271238
4nucleobase catabolic process (GO:0046113)3.98741406
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31194454
6negative regulation of cell killing (GO:0031342)3.31194454
7gamma-aminobutyric acid transport (GO:0015812)3.28784056
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18938862
9positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.16592178
10mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.16592178
11behavioral response to nicotine (GO:0035095)3.05121968
12protein K11-linked deubiquitination (GO:0035871)2.95690195
13microtubule nucleation (GO:0007020)2.91872490
14regulation of telomere maintenance (GO:0032204)2.89370575
15positive regulation of gamma-delta T cell activation (GO:0046645)2.88978160
16negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87170224
17histone H3-K9 methylation (GO:0051567)2.83688355
18protein polyglutamylation (GO:0018095)2.74662456
19olfactory bulb development (GO:0021772)2.73398208
20protein localization to cilium (GO:0061512)2.71620733
21positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.69161077
22positive T cell selection (GO:0043368)2.68718905
23histone H3-K9 modification (GO:0061647)2.66980934
24transmission of nerve impulse (GO:0019226)2.65457950
25forebrain neuron differentiation (GO:0021879)2.65021373
26RNA destabilization (GO:0050779)2.63829610
27presynaptic membrane assembly (GO:0097105)2.61374354
28negative regulation of mast cell activation (GO:0033004)2.61008475
29nonmotile primary cilium assembly (GO:0035058)2.59768626
30neurotransmitter-gated ion channel clustering (GO:0072578)2.59346932
31retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59243955
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.58603600
33protein localization to Golgi apparatus (GO:0034067)2.58426599
34central nervous system projection neuron axonogenesis (GO:0021952)2.56929292
35neuron cell-cell adhesion (GO:0007158)2.56151749
36phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.56057358
37peptidyl-lysine trimethylation (GO:0018023)2.53726809
38axoneme assembly (GO:0035082)2.52958007
39regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52448962
40auditory behavior (GO:0031223)2.52040054
41* histone H3-K4 methylation (GO:0051568)2.49666232
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49535908
43regulation of cilium movement (GO:0003352)2.48425294
44positive regulation of developmental pigmentation (GO:0048087)2.46800012
45positive regulation of oligodendrocyte differentiation (GO:0048714)2.45715471
46negative regulation of neurotransmitter transport (GO:0051589)2.45628733
47regulation of collateral sprouting (GO:0048670)2.45591950
48retinal cone cell development (GO:0046549)2.44857636
49cerebellar Purkinje cell differentiation (GO:0021702)2.44394286
50vocalization behavior (GO:0071625)2.44060996
51postsynaptic membrane organization (GO:0001941)2.43679200
52epithelial cilium movement (GO:0003351)2.42226766
53negative regulation of telomere maintenance (GO:0032205)2.42223372
54regulation of synaptic transmission, glutamatergic (GO:0051966)2.39278071
55cAMP catabolic process (GO:0006198)2.39180256
56negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39103959
57cytoplasmic mRNA processing body assembly (GO:0033962)2.38449283
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37609579
59response to pheromone (GO:0019236)2.37183064
60cilium morphogenesis (GO:0060271)2.36850736
61positive regulation of mRNA catabolic process (GO:0061014)2.35515027
62negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35021234
63negative regulation of translation, ncRNA-mediated (GO:0040033)2.35021234
64regulation of translation, ncRNA-mediated (GO:0045974)2.35021234
65cellular response to interleukin-15 (GO:0071350)2.34968837
66regulation of feeding behavior (GO:0060259)2.33603287
67negative T cell selection (GO:0043383)2.32873681
68nerve growth factor signaling pathway (GO:0038180)2.31492458
69dendrite morphogenesis (GO:0048813)2.31253840
70glutamate receptor signaling pathway (GO:0007215)2.30743661
71neuronal action potential (GO:0019228)2.29436366
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.27693611
73glycosphingolipid biosynthetic process (GO:0006688)2.27413245
74presynaptic membrane organization (GO:0097090)2.26966114
75regulation of T cell tolerance induction (GO:0002664)2.26957867
76mechanosensory behavior (GO:0007638)2.26337490
77head development (GO:0060322)2.25063676
78establishment of mitochondrion localization (GO:0051654)2.24966129
79positive regulation of CREB transcription factor activity (GO:0032793)2.24312304
80neurofilament cytoskeleton organization (GO:0060052)2.24169975
81behavioral response to ethanol (GO:0048149)2.22930335
82cilium organization (GO:0044782)2.22908311
83intra-Golgi vesicle-mediated transport (GO:0006891)2.22483185
84neuron recognition (GO:0008038)2.21901893
85negative thymic T cell selection (GO:0045060)2.21738910
86positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21476477
87CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.21380957
88vesicle transport along microtubule (GO:0047496)2.21292093
89retinal ganglion cell axon guidance (GO:0031290)2.20109047
90cerebral cortex radially oriented cell migration (GO:0021799)2.20043984
91negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.19819078
92positive thymic T cell selection (GO:0045059)2.19607706
93regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.19473127
94dentate gyrus development (GO:0021542)2.19276443
95central nervous system neuron axonogenesis (GO:0021955)2.18288253
96protein targeting to Golgi (GO:0000042)2.18162939
97regulation of B cell receptor signaling pathway (GO:0050855)2.18146768
98T cell selection (GO:0045058)2.16658478
99dendritic spine morphogenesis (GO:0060997)2.15344091
100regulation of respiratory system process (GO:0044065)2.14876717
101mRNA splice site selection (GO:0006376)2.14772009
102B cell receptor signaling pathway (GO:0050853)2.13536684
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.12597409
104T-helper cell differentiation (GO:0042093)2.09807007
105CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.09807007
106histone H3-K36 demethylation (GO:0070544)2.09593407
107eye photoreceptor cell differentiation (GO:0001754)2.09319622
108photoreceptor cell differentiation (GO:0046530)2.09319622
109positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.09265244
110regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.09265244
111B cell homeostasis (GO:0001782)2.07605699
112regulation of glutamate receptor signaling pathway (GO:1900449)2.07221291
113somite development (GO:0061053)2.06274164
114axonal fasciculation (GO:0007413)2.05515654
115embryonic hemopoiesis (GO:0035162)2.05385334
116limb bud formation (GO:0060174)2.04646646
117interferon-gamma production (GO:0032609)2.04493633
118activated T cell proliferation (GO:0050798)2.04410614
119establishment of protein localization to Golgi (GO:0072600)2.02828484
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.01754886
121neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.01641415
122regulation of respiratory gaseous exchange (GO:0043576)2.01287503
123startle response (GO:0001964)1.99426061
124regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)1.99333782
125positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)1.99333782
126response to interleukin-15 (GO:0070672)1.99299418
127negative regulation of T cell mediated immunity (GO:0002710)1.99019006
128regulation of gamma-delta T cell activation (GO:0046643)1.95803339
129negative regulation of synaptic transmission, GABAergic (GO:0032229)1.94669369
130definitive hemopoiesis (GO:0060216)1.93550349
131positive regulation of cardiac muscle cell differentiation (GO:2000727)1.92891119
132embryonic camera-type eye morphogenesis (GO:0048596)1.91226497
133alpha-beta T cell differentiation (GO:0046632)1.87608136
134regulation of gamma-delta T cell differentiation (GO:0045586)1.87411663
135interkinetic nuclear migration (GO:0022027)1.86922358
136thymic T cell selection (GO:0045061)1.86627788
137locomotory exploration behavior (GO:0035641)1.85928849
138gamma-aminobutyric acid signaling pathway (GO:0007214)1.85160212
139cell differentiation in hindbrain (GO:0021533)1.85097778
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.83842752
141long-term synaptic potentiation (GO:0060291)1.83684557
142glial cell proliferation (GO:0014009)1.83326656
143regulation of excitatory postsynaptic membrane potential (GO:0060079)1.83202667
144regulation of DNA endoreduplication (GO:0032875)1.82073749
145protein localization to synapse (GO:0035418)1.80850828
146negative regulation of osteoblast proliferation (GO:0033689)1.79680242
147synaptic transmission, glutamatergic (GO:0035249)1.79293925
148regulation of postsynaptic membrane potential (GO:0060078)1.79248939
149alpha-beta T cell differentiation involved in immune response (GO:0002293)1.78366364
150alpha-beta T cell activation involved in immune response (GO:0002287)1.78366364
151T cell differentiation involved in immune response (GO:0002292)1.78366364
152* histone lysine methylation (GO:0034968)1.77506645
153positive regulation of synapse assembly (GO:0051965)1.77116791
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.76926134
155synapse assembly (GO:0007416)1.76904308
156regulation of regulatory T cell differentiation (GO:0045589)1.76184705
157regulation of histone deacetylation (GO:0031063)1.76121682
158regulation of platelet aggregation (GO:0090330)1.75995703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.37286458
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11134564
3GBX2_23144817_ChIP-Seq_PC3_Human2.87070784
4ZNF274_21170338_ChIP-Seq_K562_Hela2.83503641
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53263962
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25482885
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.23593909
8VDR_22108803_ChIP-Seq_LS180_Human2.22681967
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.21041590
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13157290
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08092132
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07095313
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06677930
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.98408448
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.96494245
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95821853
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91186021
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89950871
19DROSHA_22980978_ChIP-Seq_HELA_Human1.87198845
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86973474
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86973474
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80773036
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.79834950
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.79006989
25AR_21572438_ChIP-Seq_LNCaP_Human1.78984206
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.78020180
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74057133
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70656124
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68423696
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64654890
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64485315
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.61185256
33TAF15_26573619_Chip-Seq_HEK293_Human1.60256151
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57926047
35RUNX_20019798_ChIP-Seq_JUKART_Human1.57638046
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56963386
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55174115
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.52300655
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50623281
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49694238
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49602807
42CBP_20019798_ChIP-Seq_JUKART_Human1.48976882
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48976882
44SMAD4_21799915_ChIP-Seq_A2780_Human1.48641977
45P300_19829295_ChIP-Seq_ESCs_Human1.47413722
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47070778
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.46579161
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45584804
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42984053
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42273751
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.40784492
52TP53_16413492_ChIP-PET_HCT116_Human1.39626175
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39618561
54IGF1R_20145208_ChIP-Seq_DFB_Human1.39549435
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34460813
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34324166
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33113914
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.32781818
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.30344815
60AHR_22903824_ChIP-Seq_MCF-7_Human1.29099281
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28776766
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28587732
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.27648901
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27300102
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27220336
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27220336
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25992376
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25963557
69TP53_18474530_ChIP-ChIP_U2OS_Human1.23358689
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23065407
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22431221
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.21721242
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21632916
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20319557
75FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19832181
76IRF1_19129219_ChIP-ChIP_H3396_Human1.19427623
77SCL_19346495_ChIP-Seq_HPC-7_Human1.19190169
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18582663
79STAT3_23295773_ChIP-Seq_U87_Human1.17524399
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.17380222
81FUS_26573619_Chip-Seq_HEK293_Human1.15921951
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15898102
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15414034
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14886289
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14421880
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13874951
87AR_25329375_ChIP-Seq_VCAP_Human1.13180413
88TCF4_23295773_ChIP-Seq_U87_Human1.11220477
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11024420
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.10700157
91REST_21632747_ChIP-Seq_MESCs_Mouse1.09503142
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09376608
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08857344
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08586789
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08331975
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08224477
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08125038
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.07903934
99TCF4_22108803_ChIP-Seq_LS180_Human1.07575510
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.06714604
101VDR_24787735_ChIP-Seq_THP-1_Human1.06122128
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05794456
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04542903
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.04532370
105RNF2_27304074_Chip-Seq_NSC_Mouse1.04467007
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04397843
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03114526
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.03001535
109RUNX2_22187159_ChIP-Seq_PCA_Human1.02452423
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02127077
111TP53_22573176_ChIP-Seq_HFKS_Human1.02036384
112BP1_19119308_ChIP-ChIP_Hs578T_Human1.01281546
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.00778698
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00593511
115AR_19668381_ChIP-Seq_PC3_Human1.00381440
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.00222825
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00106268
118RXR_22108803_ChIP-Seq_LS180_Human0.99951305
119KDM2B_26808549_Chip-Seq_REH_Human0.99415879
120NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99189706
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97918529
122BCAT_22108803_ChIP-Seq_LS180_Human0.97739324
123ER_23166858_ChIP-Seq_MCF-7_Human0.97479967
124EWS_26573619_Chip-Seq_HEK293_Human0.96763526
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.96619479
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.96068658
127P53_22387025_ChIP-Seq_ESCs_Mouse0.95609463
128NOTCH1_21737748_ChIP-Seq_TLL_Human0.94688481
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93904477
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.93699220
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93678826
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.92393827
133OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92251696
134SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91036998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.83518612
2MP0003787_abnormal_imprinting3.16036761
3MP0008877_abnormal_DNA_methylation2.76639831
4MP0005409_darkened_coat_color2.48976268
5MP0003880_abnormal_central_pattern2.42054864
6MP0002822_catalepsy2.27947425
7MP0002102_abnormal_ear_morphology2.23834659
8MP0004859_abnormal_synaptic_plasticity2.21808216
9MP0006276_abnormal_autonomic_nervous2.13135820
10MP0001188_hyperpigmentation2.10658994
11MP0003045_fibrosis2.03054462
12MP0005423_abnormal_somatic_nervous1.97338630
13MP0008995_early_reproductive_senescence1.91323879
14MP0002009_preneoplasia1.87391636
15MP0004142_abnormal_muscle_tone1.86667769
16MP0003635_abnormal_synaptic_transmissio1.86234754
17MP0006292_abnormal_olfactory_placode1.85487370
18MP0001486_abnormal_startle_reflex1.81358765
19MP0005174_abnormal_tail_pigmentation1.79625318
20MP0000778_abnormal_nervous_system1.68334970
21MP0003724_increased_susceptibility_to1.68314986
22MP0005671_abnormal_response_to1.68024873
23MP0005551_abnormal_eye_electrophysiolog1.65818507
24MP0009780_abnormal_chondrocyte_physiolo1.64573823
25MP0001529_abnormal_vocalization1.59338556
26MP0005646_abnormal_pituitary_gland1.57882942
27MP0002166_altered_tumor_susceptibility1.53430639
28MP0002736_abnormal_nociception_after1.53089772
29MP0002735_abnormal_chemical_nociception1.48828151
30MP0000015_abnormal_ear_pigmentation1.47058780
31MP0002063_abnormal_learning/memory/cond1.43912356
32MP0005387_immune_system_phenotype1.40998170
33MP0001790_abnormal_immune_system1.40998170
34MP0002572_abnormal_emotion/affect_behav1.40957484
35MP0001502_abnormal_circadian_rhythm1.37922662
36MP0003183_abnormal_peptide_metabolism1.37636142
37MP0009745_abnormal_behavioral_response1.37179407
38MP0008961_abnormal_basal_metabolism1.36802950
39MP0008569_lethality_at_weaning1.34967479
40MP0001986_abnormal_taste_sensitivity1.34787644
41MP0005645_abnormal_hypothalamus_physiol1.34278794
42MP0002653_abnormal_ependyma_morphology1.32433236
43MP0005499_abnormal_olfactory_system1.32280102
44MP0005394_taste/olfaction_phenotype1.32280102
45MP0004270_analgesia1.31886486
46MP0003763_abnormal_thymus_physiology1.31851969
47MP0004043_abnormal_pH_regulation1.30841846
48MP0000566_synostosis1.28228016
49MP0001970_abnormal_pain_threshold1.26387451
50MP0001835_abnormal_antigen_presentation1.25340830
51MP0004510_myositis1.24920843
52MP0002557_abnormal_social/conspecific_i1.23416417
53MP0001800_abnormal_humoral_immune1.22114174
54MP0003122_maternal_imprinting1.21846925
55MP0002064_seizures1.21756072
56MP0001879_abnormal_lymphatic_vessel1.21498667
57MP0000631_abnormal_neuroendocrine_gland1.18823499
58MP0002095_abnormal_skin_pigmentation1.17952774
59MP0000427_abnormal_hair_cycle1.17506885
60MP0002733_abnormal_thermal_nociception1.16303340
61MP0001984_abnormal_olfaction1.14298527
62MP0002938_white_spotting1.13401939
63MP0002006_tumorigenesis1.12612144
64MP0002067_abnormal_sensory_capabilities1.12168001
65MP0005075_abnormal_melanosome_morpholog1.11852222
66MP0002184_abnormal_innervation1.10823126
67MP0002751_abnormal_autonomic_nervous1.09249382
68MP0006072_abnormal_retinal_apoptosis1.09168721
69MP0004742_abnormal_vestibular_system1.09149554
70MP0004145_abnormal_muscle_electrophysio1.06406405
71MP0003121_genomic_imprinting1.04881587
72MP0008789_abnormal_olfactory_epithelium1.04701347
73MP0003300_gastrointestinal_ulcer1.02675197
74MP0004133_heterotaxia1.02332538
75MP0004808_abnormal_hematopoietic_stem1.01125043
76MP0001501_abnormal_sleep_pattern0.98341192
77MP0005187_abnormal_penis_morphology0.98216531
78MP0002420_abnormal_adaptive_immunity0.96051291
79MP0002452_abnormal_antigen_presenting0.95846133
80MP0005253_abnormal_eye_physiology0.94150086
81MP0001819_abnormal_immune_cell0.93601703
82MP0002272_abnormal_nervous_system0.93406341
83MP0008872_abnormal_physiological_respon0.91466756
84MP0000703_abnormal_thymus_morphology0.90248649
85MP0004381_abnormal_hair_follicle0.89825236
86MP0001968_abnormal_touch/_nociception0.89815460
87MP0005000_abnormal_immune_tolerance0.88868125
88MP0002752_abnormal_somatic_nervous0.88650721
89MP0002723_abnormal_immune_serum0.87905040
90MP0003385_abnormal_body_wall0.87617517
91MP0005171_absent_coat_pigmentation0.87341508
92MP0009046_muscle_twitch0.87112666
93MP0002909_abnormal_adrenal_gland0.85121774
94MP0003633_abnormal_nervous_system0.85028647
95MP0000465_gastrointestinal_hemorrhage0.84529410
96MP0002882_abnormal_neuron_morphology0.84473225
97MP0002398_abnormal_bone_marrow0.83155923
98MP0004924_abnormal_behavior0.82554080
99MP0005386_behavior/neurological_phenoty0.82554080
100MP0002998_abnormal_bone_remodeling0.81648674
101MP0002933_joint_inflammation0.81562633
102MP0003866_abnormal_defecation0.80182132
103MP0005310_abnormal_salivary_gland0.79805955
104MP0002177_abnormal_outer_ear0.79595768
105MP0000049_abnormal_middle_ear0.79346655
106MP0000647_abnormal_sebaceous_gland0.79018377
107MP0001873_stomach_inflammation0.76853602
108MP0004134_abnormal_chest_morphology0.76631783
109MP0003303_peritoneal_inflammation0.76087386
110MP0005503_abnormal_tendon_morphology0.75018942
111MP0000955_abnormal_spinal_cord0.74192138
112MP0001851_eye_inflammation0.74128700
113MP0002152_abnormal_brain_morphology0.73601678
114MP0001270_distended_abdomen0.72588249
115MP0001905_abnormal_dopamine_level0.72401596
116MP0000716_abnormal_immune_system0.71942684
117MP0002229_neurodegeneration0.71514489
118MP0005379_endocrine/exocrine_gland_phen0.71079372
119MP0004885_abnormal_endolymph0.70876657
120MP0002066_abnormal_motor_capabilities/c0.70200702
121MP0001485_abnormal_pinna_reflex0.70064630
122MP0010386_abnormal_urinary_bladder0.69953367
123MP0010368_abnormal_lymphatic_system0.68918622
124MP0000685_abnormal_immune_system0.68907103
125MP0002928_abnormal_bile_duct0.68709823
126MP0003935_abnormal_craniofacial_develop0.68590429
127MP0002734_abnormal_mechanical_nocicepti0.68281056
128MP0003631_nervous_system_phenotype0.68161930
129MP0002116_abnormal_craniofacial_bone0.68137391
130MP0002876_abnormal_thyroid_physiology0.66679623
131MP0004484_altered_response_of0.66160229
132MP0001346_abnormal_lacrimal_gland0.64377624
133MP0003890_abnormal_embryonic-extraembry0.64273298
134MP0001324_abnormal_eye_pigmentation0.63555348
135MP0009250_abnormal_appendicular_skeleto0.63315746
136MP0004811_abnormal_neuron_physiology0.62816874
137MP0002638_abnormal_pupillary_reflex0.62384201
138MP0001440_abnormal_grooming_behavior0.62132521
139MP0002148_abnormal_hypersensitivity_rea0.61280436
140MP0000383_abnormal_hair_follicle0.61211165
141MP0005195_abnormal_posterior_eye0.61010315

Predicted human phenotypes

RankGene SetZ-score
1Gait imbalance (HP:0002141)3.43464995
2Medial flaring of the eyebrow (HP:0010747)3.36642747
3Volvulus (HP:0002580)3.33364799
4Abnormality of the fingertips (HP:0001211)3.31344414
5Pancreatic cysts (HP:0001737)3.30667527
6Chronic hepatic failure (HP:0100626)3.19421526
7Congenital primary aphakia (HP:0007707)3.12349398
8Molar tooth sign on MRI (HP:0002419)3.11151280
9Abnormality of midbrain morphology (HP:0002418)3.11151280
10Pancreatic fibrosis (HP:0100732)3.06124774
11Febrile seizures (HP:0002373)3.04733689
12Nephrogenic diabetes insipidus (HP:0009806)3.04131170
13True hermaphroditism (HP:0010459)3.02771235
14Abnormal hair whorl (HP:0010721)3.01372201
15Nephronophthisis (HP:0000090)2.89735327
16Amyotrophic lateral sclerosis (HP:0007354)2.84692466
17Epileptic encephalopathy (HP:0200134)2.79491848
18Agammaglobulinemia (HP:0004432)2.78054663
19Protruding tongue (HP:0010808)2.76090211
20Broad-based gait (HP:0002136)2.73500706
21Abnormality of the renal medulla (HP:0100957)2.72603931
22Tented upper lip vermilion (HP:0010804)2.70927801
23Genetic anticipation (HP:0003743)2.67146808
24Poor coordination (HP:0002370)2.62771429
25Widely spaced teeth (HP:0000687)2.55503676
26Macroorchidism (HP:0000053)2.55236615
27Progressive cerebellar ataxia (HP:0002073)2.53256941
28Severe combined immunodeficiency (HP:0004430)2.52170060
29Abnormality of the renal cortex (HP:0011035)2.51802015
30Abnormality of the nasal septum (HP:0000419)2.51543723
31Genital tract atresia (HP:0001827)2.49603726
32Polyphagia (HP:0002591)2.48149886
33Vaginal atresia (HP:0000148)2.44773332
34Congenital stationary night blindness (HP:0007642)2.44754347
35Lissencephaly (HP:0001339)2.39041164
36Exotropia (HP:0000577)2.35324503
37Specific learning disability (HP:0001328)2.31337388
38Oligodactyly (hands) (HP:0001180)2.29967506
39Narrow palate (HP:0000189)2.28600727
40Limb dystonia (HP:0002451)2.25694298
41Midline defect of the nose (HP:0004122)2.25154469
42Intestinal atresia (HP:0011100)2.24539674
43Excessive salivation (HP:0003781)2.24370969
44Drooling (HP:0002307)2.24370969
45Panhypogammaglobulinemia (HP:0003139)2.24075533
46Focal motor seizures (HP:0011153)2.23113746
47Long eyelashes (HP:0000527)2.19835108
48Thyroiditis (HP:0100646)2.19591473
49Hyperventilation (HP:0002883)2.18868648
50Lip pit (HP:0100267)2.16424679
51Papillary thyroid carcinoma (HP:0002895)2.15120642
52Trigonocephaly (HP:0000243)2.14418291
53Pachygyria (HP:0001302)2.12931133
54Inability to walk (HP:0002540)2.11792489
55Dialeptic seizures (HP:0011146)2.09917764
56Stomatitis (HP:0010280)2.09653665
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.09591377
58Papilledema (HP:0001085)2.09005468
59Abnormality of T cell number (HP:0011839)2.08694397
60Abnormality of the right ventricle (HP:0001707)2.08691205
61Abnormality of eosinophils (HP:0001879)2.07201888
62Fair hair (HP:0002286)2.04045487
63Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02907505
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.02907505
65Renal cortical cysts (HP:0000803)2.02663267
66Cystic liver disease (HP:0006706)2.02457416
67Progressive inability to walk (HP:0002505)2.02083383
68Generalized hypopigmentation of hair (HP:0011358)2.01557324
69Broad alveolar ridges (HP:0000187)2.01184667
70Agitation (HP:0000713)1.98441997
71Focal seizures (HP:0007359)1.97465908
72Thick eyebrow (HP:0000574)1.96434934
73Hemiparesis (HP:0001269)1.95540217
74Absent frontal sinuses (HP:0002688)1.95490622
75Obsessive-compulsive behavior (HP:0000722)1.93661438
76White forelock (HP:0002211)1.91877877
77Abnormality of the parietal bone (HP:0002696)1.90094093
78Stereotypic behavior (HP:0000733)1.88413603
79Hypothermia (HP:0002045)1.88342891
80Short foot (HP:0001773)1.88048338
81Open mouth (HP:0000194)1.87780076
82Neoplasm of the tracheobronchial system (HP:0100552)1.87643700
83Narrow forehead (HP:0000341)1.87380230
84Hip dysplasia (HP:0001385)1.87245397
85Hypoplastic iliac wings (HP:0002866)1.86897096
86Postaxial hand polydactyly (HP:0001162)1.86852375
87Cupped ear (HP:0000378)1.86243479
88Retinal dysplasia (HP:0007973)1.85471536
89Absent speech (HP:0001344)1.85431732
90Inappropriate behavior (HP:0000719)1.83048340
91Abnormality of the columella (HP:0009929)1.80544213
92Recurrent cutaneous fungal infections (HP:0011370)1.79572199
93Chronic mucocutaneous candidiasis (HP:0002728)1.79572199
94Thyroid-stimulating hormone excess (HP:0002925)1.79509741
95Abnormality of salivation (HP:0100755)1.79385205
96Gaze-evoked nystagmus (HP:0000640)1.77804171
97Abnormality of the corticospinal tract (HP:0002492)1.77714482
98Broad foot (HP:0001769)1.76937739
99Abnormality of the labia minora (HP:0012880)1.76710742
100Postaxial foot polydactyly (HP:0001830)1.76219902
101Aplasia/Hypoplasia of the lens (HP:0008063)1.75929114
102Intellectual disability, severe (HP:0010864)1.74192885
103Failure to thrive in infancy (HP:0001531)1.74176763
104Blue irides (HP:0000635)1.73418253
105Abnormality of the intervertebral disk (HP:0005108)1.73110599
106Abnormality of incisor morphology (HP:0011063)1.71912620
107Aqueductal stenosis (HP:0002410)1.71822492
108Increased corneal curvature (HP:0100692)1.71032267
109Keratoconus (HP:0000563)1.71032267
110Supernumerary ribs (HP:0005815)1.70980002
111Narrow nasal bridge (HP:0000446)1.70450134
112Optic neuritis (HP:0100653)1.70017992
113Retrobulbar optic neuritis (HP:0100654)1.70017992
114Anteriorly placed anus (HP:0001545)1.69930708
115IgG deficiency (HP:0004315)1.69500609
116Bony spicule pigmentary retinopathy (HP:0007737)1.69094998
117Deeply set eye (HP:0000490)1.68685999
118Congenital hepatic fibrosis (HP:0002612)1.68392154
119Congenital sensorineural hearing impairment (HP:0008527)1.68324085
120Atonic seizures (HP:0010819)1.68249904
121Alveolar cell carcinoma (HP:0006519)1.67625549
122Abnormality of binocular vision (HP:0011514)1.66574516
123Diplopia (HP:0000651)1.66574516
124Short 4th metacarpal (HP:0010044)1.65956132
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.65956132
126Growth hormone deficiency (HP:0000824)1.64505308
127Truncal ataxia (HP:0002078)1.64339195
128Hypsarrhythmia (HP:0002521)1.63793831
129Recurrent fungal infections (HP:0002841)1.63587011
130Epileptiform EEG discharges (HP:0011182)1.63432645
131EEG with generalized epileptiform discharges (HP:0011198)1.63145258
132Dyskinesia (HP:0100660)1.62512506
133Prominent nasal bridge (HP:0000426)1.61203340
134Hypoplasia of the maxilla (HP:0000327)1.61071381
135Tubulointerstitial nephritis (HP:0001970)1.61027659
136Patchy hypopigmentation of hair (HP:0011365)1.60998349
137Recurrent viral infections (HP:0004429)1.60528095
138Abolished electroretinogram (ERG) (HP:0000550)1.59826136
139Synophrys (HP:0000664)1.59310838
140Absence seizures (HP:0002121)1.59208536
141Type II lissencephaly (HP:0007260)1.58533408
142Morphological abnormality of the middle ear (HP:0008609)1.58434516
143Abnormal rod and cone electroretinograms (HP:0008323)1.57622064
144Meningitis (HP:0001287)1.56777677
145Sparse scalp hair (HP:0002209)1.55865859
146Tapered finger (HP:0001182)1.55741775
147Aplasia cutis congenita (HP:0001057)1.55378149
148Obstructive sleep apnea (HP:0002870)1.55243960
149Acute lymphatic leukemia (HP:0006721)1.54868940
150Thickened helices (HP:0000391)1.54333756
151Neoplasm of the adrenal cortex (HP:0100641)1.54029808
152Deep philtrum (HP:0002002)1.52175096
153Spinal cord lesions (HP:0100561)1.51419642
154Syringomyelia (HP:0003396)1.51419642
155Abnormality of the incisor (HP:0000676)1.50847476
156Short philtrum (HP:0000322)1.46790338
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.46771908
158Stomach cancer (HP:0012126)1.45885387
159Truncal obesity (HP:0001956)1.45858473
160Inflammation of the large intestine (HP:0002037)1.45653301
161Arterial tortuosity (HP:0005116)1.45400441
162Submucous cleft hard palate (HP:0000176)1.45086135
163Decreased circulating renin level (HP:0003351)1.44454081
164Supernumerary bones of the axial skeleton (HP:0009144)1.44200459
165T lymphocytopenia (HP:0005403)1.44097634
166Smooth philtrum (HP:0000319)1.44055109
167Highly arched eyebrow (HP:0002553)1.44025135
168Anal stenosis (HP:0002025)1.42879588
169Autism (HP:0000717)1.42468551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.87193379
2SIK32.64648238
3SIK22.63246450
4CAMK1G2.55048986
5TNIK2.44203122
6BRD42.39495664
7TXK2.39045774
8INSRR2.24522667
9CASK1.96365656
10MAP4K21.95161694
11MARK11.85896003
12WNK31.85105198
13CAMK1D1.84482662
14FGFR21.71900843
15RIPK41.62095348
16DMPK1.61872002
17NTRK21.57489975
18FGFR31.55143579
19PAK31.52207543
20NTRK31.45847934
21MAPK131.45410396
22PINK11.41241646
23CDK31.39350262
24MAP4K11.36744143
25TRIM281.35895100
26HIPK21.31329911
27MARK21.31035899
28SGK21.29620830
29ERBB31.22405878
30NUAK11.21647209
31MAP2K71.20574095
32EPHA41.20524843
33ADRBK21.19982294
34EPHA31.18001664
35ITK1.16599533
36WNK11.13471511
37BMPR1B1.13453876
38MAPK151.11223172
39CSNK1G21.08766016
40DYRK21.07970666
41FES1.05755120
42SGK31.05425321
43AKT31.03537633
44JAK11.03367950
45YES10.98948718
46SYK0.97946154
47MAP3K40.96774573
48MAP3K140.95560860
49DYRK1A0.94867088
50IRAK40.94843047
51CAMK40.92984172
52PRPF4B0.92978614
53BMPR20.92164675
54EPHB10.90692888
55MAPK70.88916267
56HCK0.88627016
57CLK10.87004316
58PKN10.85345243
59NEK60.85249005
60IRAK10.83456267
61MINK10.82943525
62CAMK10.82785440
63GRK70.82690797
64CHUK0.82516477
65SGK2230.82456878
66SGK4940.82456878
67CDK90.82091847
68CSNK1G30.81763575
69CDK120.80300411
70PRKCH0.80014044
71TNK20.78548654
72RPS6KA40.78519077
73TGFBR20.77868474
74TEC0.74950166
75SGK10.74457341
76BTK0.74315422
77UHMK10.74186336
78PRKCE0.74168412
79KIT0.73293769
80SIK10.73229812
81CSNK1G10.71798196
82PRKCQ0.71520367
83NLK0.70935868
84IRAK20.70619155
85IKBKE0.69924116
86PRKD20.69876184
87KSR10.69399425
88LCK0.68260877
89DAPK20.67092908
90BCKDK0.66867585
91CDC42BPA0.66540280
92MAP3K120.66366267
93GRK60.66153958
94CAMKK10.64257686
95CAMKK20.64244498
96MAP3K70.63906585
97DYRK30.62898933
98FYN0.62830189
99PIK3CA0.62564217
100MAPK120.61853341
101IRAK30.61398523
102JAK30.60195364
103CDK50.59050245
104GRK10.58468939
105BLK0.57799747
106TAOK30.56835302
107PRKCG0.56806294
108PLK20.56710778
109DYRK1B0.56241998
110CSNK1A1L0.55886429
111LYN0.55432118
112STK110.55337842
113ERBB20.54529867
114MAP3K130.52895825
115MAP3K60.52779393
116PDGFRB0.52272546
117PRKG10.52084584
118PRKAA20.52070159
119STK240.51835843
120WNK40.51736229
121PNCK0.51601194
122ACVR1B0.50153706
123OXSR10.49976504
124MARK30.49695370
125BCR0.49676935
126ADRBK10.49576275
127PRKCZ0.49171488
128CSK0.48573661
129MAP2K40.47940474
130CAMK2A0.46166457
131PRKAA10.44810391

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12938047
2Nicotine addiction_Homo sapiens_hsa050331.88774313
3Regulation of autophagy_Homo sapiens_hsa041401.78249204
4Phototransduction_Homo sapiens_hsa047441.70045350
5Primary immunodeficiency_Homo sapiens_hsa053401.65568636
6Circadian entrainment_Homo sapiens_hsa047131.57878269
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51826719
8Morphine addiction_Homo sapiens_hsa050321.50526376
9Glutamatergic synapse_Homo sapiens_hsa047241.50213996
10T cell receptor signaling pathway_Homo sapiens_hsa046601.41679620
11Renin secretion_Homo sapiens_hsa049241.37080193
12Long-term potentiation_Homo sapiens_hsa047201.36770115
13B cell receptor signaling pathway_Homo sapiens_hsa046621.36345368
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29673142
15GABAergic synapse_Homo sapiens_hsa047271.29642516
16Type I diabetes mellitus_Homo sapiens_hsa049401.28139802
17Axon guidance_Homo sapiens_hsa043601.24432114
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23632711
19Linoleic acid metabolism_Homo sapiens_hsa005911.23234768
20Serotonergic synapse_Homo sapiens_hsa047261.21501721
21Cholinergic synapse_Homo sapiens_hsa047251.20735505
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20498607
23Dopaminergic synapse_Homo sapiens_hsa047281.20151667
24Insulin secretion_Homo sapiens_hsa049111.19806730
25Olfactory transduction_Homo sapiens_hsa047401.18374016
26Long-term depression_Homo sapiens_hsa047301.18022880
27Salivary secretion_Homo sapiens_hsa049701.17120046
28Taste transduction_Homo sapiens_hsa047421.17044339
29Amphetamine addiction_Homo sapiens_hsa050311.15894419
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15509774
31Osteoclast differentiation_Homo sapiens_hsa043801.13996196
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13995296
33cAMP signaling pathway_Homo sapiens_hsa040241.12926074
34Cocaine addiction_Homo sapiens_hsa050301.12870275
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12781931
36Oxytocin signaling pathway_Homo sapiens_hsa049211.12651091
37Ether lipid metabolism_Homo sapiens_hsa005651.07870862
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07544667
39Asthma_Homo sapiens_hsa053101.07543872
40Chemokine signaling pathway_Homo sapiens_hsa040621.04092892
41Type II diabetes mellitus_Homo sapiens_hsa049301.03518250
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02116236
43Calcium signaling pathway_Homo sapiens_hsa040201.00923016
44Collecting duct acid secretion_Homo sapiens_hsa049661.00154608
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00149146
46ErbB signaling pathway_Homo sapiens_hsa040120.97909145
47Hematopoietic cell lineage_Homo sapiens_hsa046400.97633997
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97078386
49Circadian rhythm_Homo sapiens_hsa047100.96034687
50Protein export_Homo sapiens_hsa030600.95015657
51Gastric acid secretion_Homo sapiens_hsa049710.94156477
52NF-kappa B signaling pathway_Homo sapiens_hsa040640.92627245
53Nitrogen metabolism_Homo sapiens_hsa009100.92619336
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.91853527
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91536036
56Platelet activation_Homo sapiens_hsa046110.91518979
57MAPK signaling pathway_Homo sapiens_hsa040100.91436926
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90612346
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90477949
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89730454
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89453264
62Wnt signaling pathway_Homo sapiens_hsa043100.88459117
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87674309
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87658412
65Leishmaniasis_Homo sapiens_hsa051400.87349617
66Synaptic vesicle cycle_Homo sapiens_hsa047210.87346423
67Dilated cardiomyopathy_Homo sapiens_hsa054140.87330771
68Graft-versus-host disease_Homo sapiens_hsa053320.86519354
69GnRH signaling pathway_Homo sapiens_hsa049120.86086282
70Notch signaling pathway_Homo sapiens_hsa043300.85602609
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84734540
72Measles_Homo sapiens_hsa051620.84266586
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83725704
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83355585
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.83242073
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82670634
77Melanogenesis_Homo sapiens_hsa049160.82197097
78Choline metabolism in cancer_Homo sapiens_hsa052310.81909003
79Dorso-ventral axis formation_Homo sapiens_hsa043200.81601654
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80939654
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80787014
82Autoimmune thyroid disease_Homo sapiens_hsa053200.80336389
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80192089
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.79634145
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79143747
86Colorectal cancer_Homo sapiens_hsa052100.77753595
87Glioma_Homo sapiens_hsa052140.76971755
88Basal transcription factors_Homo sapiens_hsa030220.76276069
89Viral myocarditis_Homo sapiens_hsa054160.76272032
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.76175432
91Renal cell carcinoma_Homo sapiens_hsa052110.75792116
92Pancreatic cancer_Homo sapiens_hsa052120.75340321
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74486398
94Allograft rejection_Homo sapiens_hsa053300.73615741
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.73293640
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71569904
97Ras signaling pathway_Homo sapiens_hsa040140.71551090
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71456090
99Butanoate metabolism_Homo sapiens_hsa006500.71235656
100African trypanosomiasis_Homo sapiens_hsa051430.70885517
101Prolactin signaling pathway_Homo sapiens_hsa049170.70118302
102Acute myeloid leukemia_Homo sapiens_hsa052210.69979361
103Rap1 signaling pathway_Homo sapiens_hsa040150.69616890
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.68969535
105Rheumatoid arthritis_Homo sapiens_hsa053230.68097035
106Chronic myeloid leukemia_Homo sapiens_hsa052200.67895575
107TNF signaling pathway_Homo sapiens_hsa046680.66917158
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66798771
109Toxoplasmosis_Homo sapiens_hsa051450.66250471
110Endometrial cancer_Homo sapiens_hsa052130.65960437
111ABC transporters_Homo sapiens_hsa020100.64551487
112Non-small cell lung cancer_Homo sapiens_hsa052230.64502773
113FoxO signaling pathway_Homo sapiens_hsa040680.64088473
114Hepatitis B_Homo sapiens_hsa051610.63936739
115Estrogen signaling pathway_Homo sapiens_hsa049150.63692935
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.63527087
117Adherens junction_Homo sapiens_hsa045200.63110974
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62985256
119Basal cell carcinoma_Homo sapiens_hsa052170.62710311
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60298394
121RNA degradation_Homo sapiens_hsa030180.58588296
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58580054
123Fanconi anemia pathway_Homo sapiens_hsa034600.57428890
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50406223
125Gap junction_Homo sapiens_hsa045400.48296517
126Tuberculosis_Homo sapiens_hsa051520.47862142
127Inositol phosphate metabolism_Homo sapiens_hsa005620.43731822
128mTOR signaling pathway_Homo sapiens_hsa041500.42579295
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40652174

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