KMT5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)4.93718154
2sarcomere organization (GO:0045214)4.59444162
3DNA strand elongation involved in DNA replication (GO:0006271)4.41617385
4DNA replication initiation (GO:0006270)4.39888464
5DNA strand elongation (GO:0022616)4.35544543
6ribosomal small subunit biogenesis (GO:0042274)4.25680790
7chromosome condensation (GO:0030261)4.08199538
8regulation of translational termination (GO:0006449)4.05769482
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.96929046
10meiotic chromosome segregation (GO:0045132)3.95113991
11formation of translation preinitiation complex (GO:0001731)3.94265252
12telomere maintenance via semi-conservative replication (GO:0032201)3.84673505
13bundle of His cell to Purkinje myocyte communication (GO:0086069)3.71875322
14maturation of SSU-rRNA (GO:0030490)3.68911776
15regulation of histone H3-K27 methylation (GO:0061085)3.60155920
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57452727
17chromosome segregation (GO:0007059)3.55773995
18DNA packaging (GO:0006323)3.54055786
19cardiac myofibril assembly (GO:0055003)3.50243297
20myofibril assembly (GO:0030239)3.38841047
21protoporphyrinogen IX biosynthetic process (GO:0006782)3.37080206
22muscle filament sliding (GO:0030049)3.36770261
23actin-myosin filament sliding (GO:0033275)3.36770261
24positive regulation of DNA-dependent DNA replication (GO:2000105)3.27703421
25regulation of nucleobase-containing compound transport (GO:0032239)3.27444808
26telomere maintenance via recombination (GO:0000722)3.24399622
27regulation of cardioblast differentiation (GO:0051890)3.22471574
28DNA conformation change (GO:0071103)3.22265392
293-UTR-mediated mRNA stabilization (GO:0070935)3.20604625
30negative regulation of mRNA processing (GO:0050686)3.19541509
31ribonucleoprotein complex biogenesis (GO:0022613)3.19402026
32protein localization to kinetochore (GO:0034501)3.19124673
33ribosome biogenesis (GO:0042254)3.18251162
34protein-DNA complex disassembly (GO:0032986)3.17662120
35nucleosome disassembly (GO:0006337)3.17662120
36mitotic recombination (GO:0006312)3.15218733
37DNA unwinding involved in DNA replication (GO:0006268)3.12464625
38nuclear pore complex assembly (GO:0051292)3.11281053
39positive regulation of chromosome segregation (GO:0051984)3.10399566
40folic acid metabolic process (GO:0046655)3.10096131
41apoptotic process involved in morphogenesis (GO:0060561)3.10009080
42COPI coating of Golgi vesicle (GO:0048205)3.09320022
43Golgi transport vesicle coating (GO:0048200)3.09320022
44DNA duplex unwinding (GO:0032508)3.08198023
45cardiac muscle cell development (GO:0055013)3.07998876
46proline biosynthetic process (GO:0006561)3.07107642
47negative regulation of mRNA metabolic process (GO:1903312)3.05635798
48establishment of chromosome localization (GO:0051303)3.05329114
49kinetochore assembly (GO:0051382)3.05036015
50nucleobase-containing small molecule interconversion (GO:0015949)3.04128687
51nuclear pore organization (GO:0006999)3.03739261
52negative regulation of potassium ion transmembrane transport (GO:1901380)2.99902519
53regulation of centrosome cycle (GO:0046605)2.99757667
54negative regulation of erythrocyte differentiation (GO:0045647)2.99696255
55dosage compensation (GO:0007549)2.96859162
56regulation of histone H3-K4 methylation (GO:0051569)2.96538793
57protein localization to chromosome, centromeric region (GO:0071459)2.96526078
58histone phosphorylation (GO:0016572)2.96477282
59spliceosomal tri-snRNP complex assembly (GO:0000244)2.96138151
60cardiac cell development (GO:0055006)2.94310879
61plasma membrane repair (GO:0001778)2.93686391
62DNA geometric change (GO:0032392)2.92058978
63regulation of sister chromatid cohesion (GO:0007063)2.91844678
64heterochromatin organization (GO:0070828)2.90138396
65viral mRNA export from host cell nucleus (GO:0046784)2.88909888
66cellular protein complex localization (GO:0034629)2.87879339
67chromatin assembly or disassembly (GO:0006333)2.87164396
68mRNA stabilization (GO:0048255)2.85665519
69RNA stabilization (GO:0043489)2.85665519
70hepatocyte apoptotic process (GO:0097284)2.85576757
71regulation of centriole replication (GO:0046599)2.84850610
72negative regulation of RNA splicing (GO:0033119)2.83856181
73translational termination (GO:0006415)2.82771549
74protein export from nucleus (GO:0006611)2.80908659
75actin-mediated cell contraction (GO:0070252)2.79991771
76trophectodermal cell differentiation (GO:0001829)2.79736700
77cardiac muscle tissue morphogenesis (GO:0055008)2.79125717
78creatine metabolic process (GO:0006600)2.77358901
79negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.76575555
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.74746443
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.71160903
82ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.70677373
83actomyosin structure organization (GO:0031032)2.69928434
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68609733
85regulation of translational elongation (GO:0006448)2.67885138
86regulation of spindle organization (GO:0090224)2.66332938
87mitotic chromosome condensation (GO:0007076)2.64296610
88DNA synthesis involved in DNA repair (GO:0000731)2.63723578
89regulation of chromosome segregation (GO:0051983)2.63413099
90tetrahydrofolate metabolic process (GO:0046653)2.63178031
91mitotic nuclear envelope disassembly (GO:0007077)2.62915561
92protein complex localization (GO:0031503)2.62845191
93mitotic cell cycle (GO:0000278)2.62772429
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.62271372
95regulation of mitotic spindle organization (GO:0060236)2.62172764
96microtubule depolymerization (GO:0007019)2.60784856
97regulation of DNA endoreduplication (GO:0032875)2.60211977
98mitotic metaphase plate congression (GO:0007080)2.57906329
99translational initiation (GO:0006413)2.56958276
100protein K6-linked ubiquitination (GO:0085020)2.56828107
101DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.56622344
102regulation of RNA export from nucleus (GO:0046831)2.56477485
103chromatin assembly (GO:0031497)2.55618923
104ribosomal small subunit assembly (GO:0000028)2.54713266
105desmosome organization (GO:0002934)2.54606219
106IMP metabolic process (GO:0046040)2.54554645
107glucocorticoid receptor signaling pathway (GO:0042921)2.54422988
108spindle organization (GO:0007051)2.54394568
109histone-serine phosphorylation (GO:0035404)2.52301568
110muscle tissue morphogenesis (GO:0060415)2.52208348
111IMP biosynthetic process (GO:0006188)2.42977372
112membrane disassembly (GO:0030397)2.41467675
113nuclear envelope disassembly (GO:0051081)2.41467675
114regulation of mRNA stability (GO:0043488)2.41303060
115response to UV-C (GO:0010225)2.41067396
116regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40957342
117mitotic sister chromatid segregation (GO:0000070)2.39041848
118regulation of integrin activation (GO:0033623)2.38343217
119mitotic G2 DNA damage checkpoint (GO:0007095)2.37447708
120pore complex assembly (GO:0046931)2.35956375
121heart trabecula formation (GO:0060347)2.35677109
122positive regulation of mitotic sister chromatid separation (GO:1901970)2.35363740
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.35363740
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.35363740
125sister chromatid segregation (GO:0000819)2.34490211
126nuclear envelope organization (GO:0006998)2.33792368
127actin filament-based movement (GO:0030048)2.33371881
128regulation of hippo signaling (GO:0035330)2.32739755
129DNA damage response, signal transduction resulting in transcription (GO:0042772)2.32202970
130regulation of RNA stability (GO:0043487)2.30742639
131regulation of skeletal muscle contraction (GO:0014819)2.29281527
132kinetochore organization (GO:0051383)2.29134128
133cytoplasmic mRNA processing body assembly (GO:0033962)2.28669266
134epithelial cell-cell adhesion (GO:0090136)2.26969565
135protein localization to endosome (GO:0036010)2.26435785
136mitotic G2/M transition checkpoint (GO:0044818)2.26034666
137positive regulation of SMAD protein import into nucleus (GO:0060391)2.25826639
138hippo signaling (GO:0035329)2.21177563
139negative regulation of striated muscle cell apoptotic process (GO:0010664)2.20187412
140heart process (GO:0003015)2.19337866
141heart contraction (GO:0060047)2.19337866
142cellular response to zinc ion (GO:0071294)2.17109285
143adult heart development (GO:0007512)2.16876183
144developmental programmed cell death (GO:0010623)2.16397735
145negative regulation of nucleotide catabolic process (GO:0030812)2.15552918
146activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.14945666
147mesodermal cell differentiation (GO:0048333)2.14202959
148cell differentiation involved in embryonic placenta development (GO:0060706)2.13729823
149ventricular cardiac muscle cell development (GO:0055015)2.13484224
150regulation of SMAD protein import into nucleus (GO:0060390)2.12688330
151folic acid-containing compound biosynthetic process (GO:0009396)2.12460369
152metaphase plate congression (GO:0051310)2.12419449
153regulation of translational fidelity (GO:0006450)2.12202301
154cardiac muscle contraction (GO:0060048)2.11182620
155cellular response to arsenic-containing substance (GO:0071243)2.10475138
156NLS-bearing protein import into nucleus (GO:0006607)2.10318546
157hemidesmosome assembly (GO:0031581)2.10230225
158protoporphyrinogen IX metabolic process (GO:0046501)2.09863117
159DNA replication checkpoint (GO:0000076)2.09851547
160viral transcription (GO:0019083)2.07306464
161porphyrin-containing compound biosynthetic process (GO:0006779)2.06567890
162negative regulation of purine nucleotide catabolic process (GO:0033122)2.06517302
163maternal placenta development (GO:0001893)2.06337299
164mitotic sister chromatid cohesion (GO:0007064)2.06236607
165protein localization to chromosome (GO:0034502)2.05888265
166cell-substrate junction assembly (GO:0007044)2.05305625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42458077
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38411747
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.16553816
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.02534013
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96729829
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79712096
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63525858
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58039919
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53569065
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52638730
11ZNF263_19887448_ChIP-Seq_K562_Human2.27621771
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.14244357
13AR_21909140_ChIP-Seq_LNCAP_Human2.13985813
14MYC_22102868_ChIP-Seq_BL_Human2.11271535
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.05670485
16VDR_21846776_ChIP-Seq_THP-1_Human2.01108108
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97916095
18THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83848112
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82072104
20DCP1A_22483619_ChIP-Seq_HELA_Human1.77438507
21ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73364098
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72813354
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72092454
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71703945
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71248254
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69642133
27TTF2_22483619_ChIP-Seq_HELA_Human1.67541356
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63385278
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58665811
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56097902
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52694994
32ATF3_27146783_Chip-Seq_COLON_Human1.51002623
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.49643978
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.48874843
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48156407
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47049062
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41664950
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41046314
39CIITA_25753668_ChIP-Seq_RAJI_Human1.39610118
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39567766
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39233025
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38575051
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37992641
44MAF_26560356_Chip-Seq_TH1_Human1.37908977
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37642369
46GABP_19822575_ChIP-Seq_HepG2_Human1.36666143
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36479369
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35178522
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33844256
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32831312
51GATA6_25053715_ChIP-Seq_YYC3_Human1.32443382
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32410254
53TCF7_22412390_ChIP-Seq_EML_Mouse1.32372187
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32009375
55RACK7_27058665_Chip-Seq_MCF-7_Human1.30902209
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30821508
57KDM2B_26808549_Chip-Seq_DND41_Human1.29446443
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29154206
59VDR_24763502_ChIP-Seq_THP-1_Human1.28231806
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28161406
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24240630
62XRN2_22483619_ChIP-Seq_HELA_Human1.21852512
63CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21532008
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21301027
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18906470
66GATA1_22025678_ChIP-Seq_K562_Human1.18821351
67UTX_26944678_Chip-Seq_JUKART_Human1.15571754
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15554477
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15466605
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14452121
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13052078
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13007973
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12762944
74KDM5A_27292631_Chip-Seq_BREAST_Human1.12725778
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11980345
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11858527
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11856855
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10732972
79CHD1_26751641_Chip-Seq_LNCaP_Human1.10391870
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10283705
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09973556
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09496971
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.09232653
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.09232653
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08882533
86SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08882533
87NCOR1_26117541_ChIP-Seq_K562_Human1.08874321
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08572049
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.07908431
90KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07893966
91CLOCK_20551151_ChIP-Seq_293T_Human1.07166571
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06972083
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06239756
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06002779
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05972525
96FOXP3_21729870_ChIP-Seq_TREG_Human1.05433971
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05108062
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04699129
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02893318
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02508683
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02365465
102SCL_19346495_ChIP-Seq_HPC-7_Human1.02328650
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02235502
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02131460
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01268266
106MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00973682
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00947167
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00909010
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00883676
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00741016
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00504025
112LXR_22292898_ChIP-Seq_THP-1_Human0.99579808
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99359462
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98892833
115BP1_19119308_ChIP-ChIP_Hs578T_Human0.98777112
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98339968
117UBF1/2_26484160_Chip-Seq_HMECs_Human0.98281506
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98242393
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96777031
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96649882
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96420266
122GABP_17652178_ChIP-ChIP_JURKAT_Human0.96224013
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94987352
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94734825
125SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94096479
126TFEB_21752829_ChIP-Seq_HELA_Human0.92761610
127MAF_26560356_Chip-Seq_TH2_Human0.92671902
128SPI1_23547873_ChIP-Seq_NB4_Human0.92621572
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.91961106
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91915731
131EST1_17652178_ChIP-ChIP_JURKAT_Human0.91860255
132GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91739250
133MYB_26560356_Chip-Seq_TH2_Human0.90025759
134CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89616670
135GATA1_19941826_ChIP-Seq_K562_Human0.89525951
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.89379662
137STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89144954
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.89086819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle2.70538787
2MP0010352_gastrointestinal_tract_polyps2.44539378
3MP0003705_abnormal_hypodermis_morpholog2.42716851
4MP0003646_muscle_fatigue2.30751712
5MP0003693_abnormal_embryo_hatching2.29741403
6MP0008007_abnormal_cellular_replicative2.23511067
7MP0004185_abnormal_adipocyte_glucose2.05450888
8MP0000750_abnormal_muscle_regeneration2.01579249
9MP0004087_abnormal_muscle_fiber1.99498072
10MP0002837_dystrophic_cardiac_calcinosis1.97710575
11MP0010630_abnormal_cardiac_muscle1.96334711
12MP0002009_preneoplasia1.95423153
13MP0004957_abnormal_blastocyst_morpholog1.94224764
14MP0003566_abnormal_cell_adhesion1.92528683
15MP0005330_cardiomyopathy1.89501056
16MP0008058_abnormal_DNA_repair1.89134662
17MP0004233_abnormal_muscle_weight1.85542810
18MP0005076_abnormal_cell_differentiation1.84541417
19MP0003786_premature_aging1.82992127
20MP0003221_abnormal_cardiomyocyte_apopto1.77080373
21MP0003950_abnormal_plasma_membrane1.76598975
22MP0003828_pulmonary_edema1.75932844
23MP0003111_abnormal_nucleus_morphology1.73780000
24MP0003567_abnormal_fetal_cardiomyocyte1.73587674
25MP0000749_muscle_degeneration1.70248168
26MP0010234_abnormal_vibrissa_follicle1.70077094
27MP0003077_abnormal_cell_cycle1.68105965
28MP0008775_abnormal_heart_ventricle1.66221145
29MP0000733_abnormal_muscle_development1.60665555
30MP0009379_abnormal_foot_pigmentation1.59790043
31MP0000678_abnormal_parathyroid_gland1.59209205
32MP0004036_abnormal_muscle_relaxation1.58657958
33MP0001730_embryonic_growth_arrest1.55609494
34MP0000751_myopathy1.53986614
35MP0009278_abnormal_bone_marrow1.52557014
36MP0003984_embryonic_growth_retardation1.47839026
37MP0002972_abnormal_cardiac_muscle1.45451324
38MP0004215_abnormal_myocardial_fiber1.44352877
39MP0002088_abnormal_embryonic_growth/wei1.44334082
40MP0005380_embryogenesis_phenotype1.38938663
41MP0001672_abnormal_embryogenesis/_devel1.38938663
42MP0005385_cardiovascular_system_phenoty1.38742842
43MP0001544_abnormal_cardiovascular_syste1.38742842
44MP0008057_abnormal_DNA_replication1.38619492
45MP0010094_abnormal_chromosome_stability1.38546596
46MP0005666_abnormal_adipose_tissue1.34482718
47MP0002106_abnormal_muscle_physiology1.33854893
48MP0002396_abnormal_hematopoietic_system1.32996492
49MP0000350_abnormal_cell_proliferation1.32517896
50MP0002877_abnormal_melanocyte_morpholog1.32221664
51MP0005409_darkened_coat_color1.31933310
52MP0003656_abnormal_erythrocyte_physiolo1.30581139
53MP0009697_abnormal_copulation1.29045526
54MP0010307_abnormal_tumor_latency1.27537999
55MP0003453_abnormal_keratinocyte_physiol1.25324541
56MP0004197_abnormal_fetal_growth/weight/1.22033945
57MP0003303_peritoneal_inflammation1.20276382
58MP0003300_gastrointestinal_ulcer1.19555490
59MP0008438_abnormal_cutaneous_collagen1.18254777
60MP0003942_abnormal_urinary_system1.17674459
61MP0002086_abnormal_extraembryonic_tissu1.16554084
62MP0005623_abnormal_meninges_morphology1.15350771
63MP0000490_abnormal_crypts_of1.15174466
64MP0001697_abnormal_embryo_size1.14527030
65MP0000383_abnormal_hair_follicle1.14205200
66MP0002796_impaired_skin_barrier1.13272532
67MP0005501_abnormal_skin_physiology1.12909904
68MP0008932_abnormal_embryonic_tissue1.11473509
69MP0000747_muscle_weakness1.09208854
70MP0000759_abnormal_skeletal_muscle1.09064828
71MP0002269_muscular_atrophy1.08818185
72MP0005083_abnormal_biliary_tract1.08455264
73MP0005397_hematopoietic_system_phenotyp1.08343948
74MP0001545_abnormal_hematopoietic_system1.08343948
75MP0004130_abnormal_muscle_cell1.08301175
76MP0005375_adipose_tissue_phenotype1.07141622
77MP0001849_ear_inflammation1.06322963
78MP0006138_congestive_heart_failure1.05372690
79MP0008995_early_reproductive_senescence1.04767488
80MP0009931_abnormal_skin_appearance1.04662939
81MP0000343_altered_response_to1.03407312
82MP0010678_abnormal_skin_adnexa1.02827574
83MP0000266_abnormal_heart_morphology1.02692185
84MP0009333_abnormal_splenocyte_physiolog1.02567806
85MP0000858_altered_metastatic_potential1.02398240
86MP0005275_abnormal_skin_tensile1.01648212
87MP0005620_abnormal_muscle_contractility1.00821102
88MP0005369_muscle_phenotype0.99904898
89MP0002084_abnormal_developmental_patter0.98605866
90MP0004147_increased_porphyrin_level0.98494194
91MP0004510_myositis0.98221754
92MP0002080_prenatal_lethality0.97537084
93MP0002249_abnormal_larynx_morphology0.97522663
94MP0002085_abnormal_embryonic_tissue0.97121783
95MP0005451_abnormal_body_composition0.97000391
96MP0005023_abnormal_wound_healing0.95462327
97MP0004808_abnormal_hematopoietic_stem0.93898393
98MP0003448_altered_tumor_morphology0.93665570
99MP0004484_altered_response_of0.93282237
100MP0005503_abnormal_tendon_morphology0.92132736
101MP0005621_abnormal_cell_physiology0.91355028
102MP0000467_abnormal_esophagus_morphology0.91039670
103MP0001881_abnormal_mammary_gland0.90761446
104MP0000428_abnormal_craniofacial_morphol0.90340399
105MP0002925_abnormal_cardiovascular_devel0.89742488
106MP0001216_abnormal_epidermal_layer0.88446651
107MP0000358_abnormal_cell_content/0.87509478
108MP0004264_abnormal_extraembryonic_tissu0.86526840
109MP0000537_abnormal_urethra_morphology0.85974954
110MP0003941_abnormal_skin_development0.85479821
111MP0000703_abnormal_thymus_morphology0.85447364
112MP0003315_abnormal_perineum_morphology0.83992988
113MP0004947_skin_inflammation0.83829760
114MP0003137_abnormal_impulse_conducting0.83166022
115MP0001661_extended_life_span0.83155947
116MP0000313_abnormal_cell_death0.81906126
117MP0009053_abnormal_anal_canal0.81838450
118MP0000003_abnormal_adipose_tissue0.81060935
119MP0000681_abnormal_thyroid_gland0.81031307
120MP0002060_abnormal_skin_morphology0.79573058
121MP0000377_abnormal_hair_follicle0.78786377
122MP0001348_abnormal_lacrimal_gland0.78770066
123MP0003937_abnormal_limbs/digits/tail_de0.78708832
124MP0001243_abnormal_dermal_layer0.77616126
125MP0005384_cellular_phenotype0.76963235
126MP0002019_abnormal_tumor_incidence0.76622958
127MP0002970_abnormal_white_adipose0.74625913
128MP0003123_paternal_imprinting0.74182784
129MP0001727_abnormal_embryo_implantation0.73124391
130MP0002098_abnormal_vibrissa_morphology0.72294010
131MP0009672_abnormal_birth_weight0.72079252
132MP0003935_abnormal_craniofacial_develop0.70816325
133MP0002210_abnormal_sex_determination0.70671351
134MP0001873_stomach_inflammation0.69099785
135MP0002166_altered_tumor_susceptibility0.65256194
136MP0002160_abnormal_reproductive_system0.64114520
137MP0000627_abnormal_mammary_gland0.61773434
138MP0002114_abnormal_axial_skeleton0.61106180
139MP0009703_decreased_birth_body0.60613567
140MP0002234_abnormal_pharynx_morphology0.60387796

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)5.15085853
2Muscle fiber splitting (HP:0003555)4.95432501
3Right ventricular cardiomyopathy (HP:0011663)4.65960467
4Sudden death (HP:0001699)4.59975565
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.35613342
6Hyporeflexia of lower limbs (HP:0002600)4.23238382
7Chromsome breakage (HP:0040012)4.12395273
8Exercise-induced muscle cramps (HP:0003710)3.95805604
9Subaortic stenosis (HP:0001682)3.90961687
10Abnormality of the left ventricular outflow tract (HP:0011103)3.90961687
11Increased connective tissue (HP:0009025)3.72570558
12Hyperthyroidism (HP:0000836)3.45265259
13Lipoatrophy (HP:0100578)3.44348536
14Cholecystitis (HP:0001082)3.38268943
15Abnormal gallbladder physiology (HP:0012438)3.38268943
16Truncus arteriosus (HP:0001660)3.30429445
17Calf muscle hypertrophy (HP:0008981)3.26116825
18Polycythemia (HP:0001901)3.10008637
19Muscle hypertrophy of the lower extremities (HP:0008968)3.08239226
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.97607838
21Atrial fibrillation (HP:0005110)2.96943017
22Ankyloglossia (HP:0010296)2.94616480
23Hypertensive crisis (HP:0100735)2.92705189
24Difficulty running (HP:0009046)2.87783415
25Insomnia (HP:0100785)2.86936089
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.82366566
27Rectal prolapse (HP:0002035)2.78976118
28Primary atrial arrhythmia (HP:0001692)2.74108939
29Reticulocytopenia (HP:0001896)2.74106286
30Hyperacusis (HP:0010780)2.73050535
31Difficulty climbing stairs (HP:0003551)2.71420983
32Birth length less than 3rd percentile (HP:0003561)2.70125687
33Dilated cardiomyopathy (HP:0001644)2.69741654
34Disproportionate tall stature (HP:0001519)2.68260571
35Supraventricular arrhythmia (HP:0005115)2.67957180
36Supraventricular tachycardia (HP:0004755)2.67868535
37Multiple enchondromatosis (HP:0005701)2.67053476
38Breast hypoplasia (HP:0003187)2.66363306
39EMG: myopathic abnormalities (HP:0003458)2.62057160
40Septate vagina (HP:0001153)2.61512962
41Patellar dislocation (HP:0002999)2.59840873
42Abnormality of cells of the erythroid lineage (HP:0012130)2.56918028
43Abnormality of the calf musculature (HP:0001430)2.54261320
44Nonimmune hydrops fetalis (HP:0001790)2.50714908
45Increased nuchal translucency (HP:0010880)2.45575177
46Pallor (HP:0000980)2.43397939
47Rhabdomyolysis (HP:0003201)2.43030053
48Squamous cell carcinoma (HP:0002860)2.41712750
49Sparse lateral eyebrow (HP:0005338)2.38868596
50Myelodysplasia (HP:0002863)2.38651809
51Hypoparathyroidism (HP:0000829)2.38378985
52Myoglobinuria (HP:0002913)2.32757647
53Abnormality of the fetal cardiovascular system (HP:0010948)2.32062646
54Abnormal umbilical cord blood vessels (HP:0011403)2.32062646
55Single umbilical artery (HP:0001195)2.32062646
56Bowel incontinence (HP:0002607)2.32044795
57Abnormality of oral frenula (HP:0000190)2.31715739
58Short middle phalanx of the 5th finger (HP:0004220)2.30349697
59Acute myeloid leukemia (HP:0004808)2.29660474
60Cholelithiasis (HP:0001081)2.28154257
61Palpitations (HP:0001962)2.27607596
62Abnormal large intestine physiology (HP:0012700)2.27363176
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.26280586
64Osteolytic defects of the hand bones (HP:0009699)2.26280586
65Overlapping toe (HP:0001845)2.24951226
66Abnormal number of erythroid precursors (HP:0012131)2.24380701
67Abnormal number of incisors (HP:0011064)2.23942598
68Progressive muscle weakness (HP:0003323)2.20316126
69Exercise-induced myalgia (HP:0003738)2.20253030
70Areflexia of lower limbs (HP:0002522)2.17868589
7111 pairs of ribs (HP:0000878)2.16078489
72Abnormality of the preputium (HP:0100587)2.13393615
73Atelectasis (HP:0100750)2.13015169
74Seborrheic dermatitis (HP:0001051)2.11441367
75Bundle branch block (HP:0011710)2.10767610
76Conjunctival hamartoma (HP:0100780)2.10338642
77Cafe-au-lait spot (HP:0000957)2.09050638
78Abnormality of the gallbladder (HP:0005264)2.07632867
79Abnormality of the umbilical cord (HP:0010881)2.06902554
80Duplicated collecting system (HP:0000081)2.06815699
81Broad distal phalanx of finger (HP:0009836)2.06705987
82Palmoplantar keratoderma (HP:0000982)2.05740420
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05030308
84Syncope (HP:0001279)2.01190233
85Small intestinal stenosis (HP:0012848)2.01174282
86Duodenal stenosis (HP:0100867)2.01174282
87Ankle contracture (HP:0006466)1.99853261
88Protrusio acetabuli (HP:0003179)1.98737239
89Deep philtrum (HP:0002002)1.98343664
90Premature rupture of membranes (HP:0001788)1.98185545
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.97169702
92Scapular winging (HP:0003691)1.96685207
93Fragile skin (HP:0001030)1.96629401
94Distal lower limb muscle weakness (HP:0009053)1.96120522
95Diaphragmatic weakness (HP:0009113)1.95509562
96Muscle fiber inclusion bodies (HP:0100299)1.93597039
97Deep palmar crease (HP:0006191)1.92454528
98Flat cornea (HP:0007720)1.90510457
99Sandal gap (HP:0001852)1.90244934
100Abnormality of chromosome segregation (HP:0002916)1.89970238
101Atrioventricular block (HP:0001678)1.89127725
102Ventricular arrhythmia (HP:0004308)1.88103229
103Abnormality of the phalanges of the hallux (HP:0010057)1.86847510
104Achilles tendon contracture (HP:0001771)1.84253167
105Abnormality of the carotid arteries (HP:0005344)1.84186379
106High anterior hairline (HP:0009890)1.83866758
107Long palpebral fissure (HP:0000637)1.83802763
108Trismus (HP:0000211)1.83714474
109Neck muscle weakness (HP:0000467)1.82454017
110Arteriovenous malformation (HP:0100026)1.82336840
111Long eyelashes (HP:0000527)1.82303518
112Shallow orbits (HP:0000586)1.81635629
113Ulnar bowing (HP:0003031)1.81462867
114Relative macrocephaly (HP:0004482)1.81458253
115Fatigue (HP:0012378)1.80493463
116Type 1 muscle fiber predominance (HP:0003803)1.80041367
117Abnormal gallbladder morphology (HP:0012437)1.78371374
118Abnormality of the fingertips (HP:0001211)1.78082499
119Missing ribs (HP:0000921)1.77883619
120Deviation of the thumb (HP:0009603)1.74885619
121Ileus (HP:0002595)1.74532662
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73031147
123Entropion (HP:0000621)1.72861897
124Pili torti (HP:0003777)1.72465442
125Slender long bone (HP:0003100)1.72382659
126Distal lower limb amyotrophy (HP:0008944)1.71519125
127Cutaneous melanoma (HP:0012056)1.71269360
128Coarctation of aorta (HP:0001680)1.71214712
129Self-mutilation (HP:0000742)1.70610303
130Orthostatic hypotension (HP:0001278)1.68890284
131Axonal loss (HP:0003447)1.68166397
132Angiofibromas (HP:0010615)1.67513174
133Adenoma sebaceum (HP:0009720)1.67513174
134Acute lymphatic leukemia (HP:0006721)1.67064504
135Selective tooth agenesis (HP:0001592)1.66389822
136Abnormality of cochlea (HP:0000375)1.65801109
137Esophageal neoplasm (HP:0100751)1.65714416
138Neoplasm of head and neck (HP:0012288)1.65714416
139Bladder diverticulum (HP:0000015)1.64596462
140Limb-girdle muscle atrophy (HP:0003797)1.64273749
141Proximal placement of thumb (HP:0009623)1.64242922
142Abnormal atrioventricular conduction (HP:0005150)1.63999359
143Nausea (HP:0002018)1.63531685
144Abnormal hemoglobin (HP:0011902)1.62642102
145Heart block (HP:0012722)1.62580375
146Abnormality of the foot musculature (HP:0001436)1.62286749
147Asymmetric septal hypertrophy (HP:0001670)1.62011114
148Thin bony cortex (HP:0002753)1.61406525
149Abnormality of the salivary glands (HP:0010286)1.59466642
150Foot dorsiflexor weakness (HP:0009027)1.58622066
151Ureteral duplication (HP:0000073)1.58254070
152Metaphyseal cupping (HP:0003021)1.58135990
153Double outlet right ventricle (HP:0001719)1.58130645
154Congenital malformation of the right heart (HP:0011723)1.58130645
155Eczematoid dermatitis (HP:0000976)1.58097900
156Poikilocytosis (HP:0004447)1.57576206
157Reticulocytosis (HP:0001923)1.56572958
158Nemaline bodies (HP:0003798)1.54575683
159Hamartoma of the eye (HP:0010568)1.54188717
160High pitched voice (HP:0001620)1.51621248
161Hypoplastic ischia (HP:0003175)1.51007044
162Flat acetabular roof (HP:0003180)1.50984529
163Limb-girdle muscle weakness (HP:0003325)1.49367546
164Cellulitis (HP:0100658)1.49171176
165Mildly elevated creatine phosphokinase (HP:0008180)1.48400009
166Abnormality of reticulocytes (HP:0004312)1.47515520
167Ventricular fibrillation (HP:0001663)1.46780134
168Abnormality of the calcaneus (HP:0008364)1.45458075
169Spinal cord lesions (HP:0100561)1.43830049
170Syringomyelia (HP:0003396)1.43830049
171Abnormality of the tricuspid valve (HP:0001702)1.42347740
172Pustule (HP:0200039)1.41394445
173Ectopic kidney (HP:0000086)1.40327053
174Autoimmune thrombocytopenia (HP:0001973)1.39477071
175Biliary tract neoplasm (HP:0100574)1.39165961
176Increased density of long bones (HP:0006392)1.38941649
177Increased serum ferritin (HP:0003281)1.37251380
178Hypochromic anemia (HP:0001931)1.36901797
179Curly hair (HP:0002212)1.36498071
180Abnormality of nail color (HP:0100643)1.36376611
181Recurrent abscess formation (HP:0002722)1.35177379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.64790799
2CDK123.31267467
3SMG12.96150185
4TRIB32.88458311
5PKN22.71131481
6IRAK32.59548977
7DMPK2.19350381
8STK102.15487656
9STK42.07134851
10CDC72.03381818
11EEF2K1.96587427
12SIK11.82264099
13STK31.78759256
14CHEK21.75784902
15EPHB11.73969714
16PRPF4B1.71959494
17CLK11.67614338
18EPHA21.66959645
19LRRK21.64164854
20TRPM71.61670804
21MAP3K101.61532599
22NEK21.57040131
23SCYL21.54010591
24STK391.52039566
25KSR21.45814208
26MAP3K81.45720523
27NME21.44297229
28BMX1.43610478
29RPS6KB21.42788157
30TTK1.41126334
31BRSK11.41045073
32LATS11.34370274
33RPS6KA41.33394072
34CDK41.23438945
35STK241.22647374
36CDK81.22534275
37BRAF1.20578550
38NEK91.19792742
39MET1.18262651
40MST41.17189995
41EIF2AK31.15575404
42NEK11.13051939
43ILK1.11285785
44PIM21.10480423
45MAP2K31.08292679
46LMTK21.07629770
47ATR1.05861111
48PTK61.04694244
49AURKA1.04197610
50OBSCN1.03963996
51CDK61.03945758
52AURKB1.03885351
53TAOK21.03087122
54CCNB11.02567474
55PIM11.01856030
56CDK71.00646146
57RAF10.99585409
58MTOR0.95665621
59SIK20.94439253
60KSR10.93228371
61ALK0.91874548
62TSSK60.89909198
63MAP2K20.89025138
64RIPK40.88148599
65BRSK20.86794703
66WNK10.86764742
67ICK0.85949484
68PNCK0.82595084
69TLK10.80724051
70MAP4K10.79028038
71PIK3CA0.78965432
72VRK20.78055941
73TESK20.76937917
74MAPK110.76829504
75EIF2AK10.76805355
76WNK40.76642600
77PLK30.76270504
78PAK40.75460907
79WEE10.75326102
80ZAK0.74821403
81LIMK10.74814324
82MAP3K30.74060516
83LATS20.74013635
84MELK0.73851371
85RPS6KA50.73372286
86MAP3K20.72897666
87MAPKAPK20.71557047
88MKNK10.69732736
89CDK10.69487437
90BLK0.67682226
91PBK0.67424573
92BRD40.67015595
93CHEK10.65078520
94PLK10.64629960
95PLK40.64614024
96TESK10.64278902
97CAMK1D0.64249808
98BUB10.63003464
99SRPK10.61650161
100PRKCI0.60793448
101AKT30.60456163
102IRAK20.59304622
103MAPKAPK30.59297280
104TBK10.59010723
105EIF2AK20.58405044
106PAK10.58285396
107PRKD10.57922757
108ERN10.56885120
109PAK20.56751993
110STK38L0.56405117
111AKT20.56129467
112PHKG10.54701206
113PHKG20.54701206
114CSK0.54685842
115NME10.54146227
116SIK30.52813167
117MAP2K10.52662412
118MARK30.52168505
119RIPK10.51747789
120RPS6KA60.51140429
121RPS6KA10.51036754
122CHUK0.50504597
123MST1R0.49206029
124MAP3K110.49121066
125PDGFRA0.48515207
126ROCK20.46258563
127BMPR20.46088653
128IRAK40.45694627
129TAF10.44690543
130RPS6KC10.43684507
131RPS6KL10.43684507
132ARAF0.43462841
133PRKAA20.42721016
134PDK40.42367941
135PDK30.42367941
136ATM0.41431951
137IKBKB0.41001686
138CDK20.40690695
139MAP3K50.40606214
140MAPKAPK50.39858243
141MAPK140.35196563
142DYRK30.33773920
143CAMK1G0.32616586

Predicted pathways (KEGG)

RankGene SetZ-score
1Viral myocarditis_Homo sapiens_hsa054162.08764762
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89843217
3Cell cycle_Homo sapiens_hsa041101.84698608
4Fanconi anemia pathway_Homo sapiens_hsa034601.80936196
5Small cell lung cancer_Homo sapiens_hsa052221.78830710
6DNA replication_Homo sapiens_hsa030301.76036386
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.71007444
8RNA transport_Homo sapiens_hsa030131.62642527
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49190527
10Chronic myeloid leukemia_Homo sapiens_hsa052201.48013073
11Ribosome_Homo sapiens_hsa030101.47077847
12Pyrimidine metabolism_Homo sapiens_hsa002401.44393335
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.43490430
14Dilated cardiomyopathy_Homo sapiens_hsa054141.40623018
15MicroRNAs in cancer_Homo sapiens_hsa052061.40397196
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37449255
17Spliceosome_Homo sapiens_hsa030401.37261946
18p53 signaling pathway_Homo sapiens_hsa041151.33105828
19One carbon pool by folate_Homo sapiens_hsa006701.29736121
20Viral carcinogenesis_Homo sapiens_hsa052031.28696268
21Leishmaniasis_Homo sapiens_hsa051401.27742753
22Basal transcription factors_Homo sapiens_hsa030221.26903405
23Adherens junction_Homo sapiens_hsa045201.25968902
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25283449
25Tight junction_Homo sapiens_hsa045301.25069877
26Carbon metabolism_Homo sapiens_hsa012001.24526215
27Systemic lupus erythematosus_Homo sapiens_hsa053221.21956200
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20391535
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19701496
30Bladder cancer_Homo sapiens_hsa052191.15512382
31Glioma_Homo sapiens_hsa052141.15224792
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14793899
33mTOR signaling pathway_Homo sapiens_hsa041501.12463818
34Base excision repair_Homo sapiens_hsa034101.11754828
35Mismatch repair_Homo sapiens_hsa034301.10757650
36Toxoplasmosis_Homo sapiens_hsa051451.10464168
37Legionellosis_Homo sapiens_hsa051341.10071366
38Proteoglycans in cancer_Homo sapiens_hsa052051.10047208
39Acute myeloid leukemia_Homo sapiens_hsa052211.07651639
40Homologous recombination_Homo sapiens_hsa034401.07090464
41Apoptosis_Homo sapiens_hsa042101.06422766
42Herpes simplex infection_Homo sapiens_hsa051681.06013510
43mRNA surveillance pathway_Homo sapiens_hsa030151.05313213
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04559876
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02586297
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.01924930
47Focal adhesion_Homo sapiens_hsa045101.01774829
48RNA polymerase_Homo sapiens_hsa030200.99912287
49ECM-receptor interaction_Homo sapiens_hsa045120.99355383
50Thyroid cancer_Homo sapiens_hsa052160.97507722
51Oocyte meiosis_Homo sapiens_hsa041140.93007639
52Colorectal cancer_Homo sapiens_hsa052100.91996120
53Lysine degradation_Homo sapiens_hsa003100.90679130
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89193495
55Renal cell carcinoma_Homo sapiens_hsa052110.88168574
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87529955
57Malaria_Homo sapiens_hsa051440.86705847
58Pancreatic cancer_Homo sapiens_hsa052120.85608585
59ErbB signaling pathway_Homo sapiens_hsa040120.84626024
60Notch signaling pathway_Homo sapiens_hsa043300.84096775
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83988924
62HTLV-I infection_Homo sapiens_hsa051660.83781186
63Salmonella infection_Homo sapiens_hsa051320.83650918
64HIF-1 signaling pathway_Homo sapiens_hsa040660.83461488
65Epstein-Barr virus infection_Homo sapiens_hsa051690.83334472
66Cardiac muscle contraction_Homo sapiens_hsa042600.83173949
67Fructose and mannose metabolism_Homo sapiens_hsa000510.83014846
68Nucleotide excision repair_Homo sapiens_hsa034200.82604183
69Amoebiasis_Homo sapiens_hsa051460.82399082
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82183224
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81298475
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81124804
73Prostate cancer_Homo sapiens_hsa052150.80626531
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80050165
75Non-homologous end-joining_Homo sapiens_hsa034500.79459267
76Shigellosis_Homo sapiens_hsa051310.78885015
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78816245
78Hippo signaling pathway_Homo sapiens_hsa043900.78033373
79Sulfur relay system_Homo sapiens_hsa041220.76835963
80Melanoma_Homo sapiens_hsa052180.76829200
81Pentose phosphate pathway_Homo sapiens_hsa000300.76450244
82Measles_Homo sapiens_hsa051620.75891264
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75020872
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74998237
85Graft-versus-host disease_Homo sapiens_hsa053320.73150372
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.72721688
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72599526
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.72129339
89Hepatitis B_Homo sapiens_hsa051610.72003460
90RNA degradation_Homo sapiens_hsa030180.71452370
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71434782
92Osteoclast differentiation_Homo sapiens_hsa043800.71339304
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70771259
94TGF-beta signaling pathway_Homo sapiens_hsa043500.70540695
95Prion diseases_Homo sapiens_hsa050200.70239928
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69069590
97Non-small cell lung cancer_Homo sapiens_hsa052230.67377415
98Propanoate metabolism_Homo sapiens_hsa006400.67010437
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66140939
100Glutathione metabolism_Homo sapiens_hsa004800.65804422
101TNF signaling pathway_Homo sapiens_hsa046680.65755250
102Antigen processing and presentation_Homo sapiens_hsa046120.65288269
103Insulin signaling pathway_Homo sapiens_hsa049100.65013749
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.64792303
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.63704739
106Pathways in cancer_Homo sapiens_hsa052000.63431751
107Insulin resistance_Homo sapiens_hsa049310.63362953
108Influenza A_Homo sapiens_hsa051640.62306439
109Purine metabolism_Homo sapiens_hsa002300.62204202
110N-Glycan biosynthesis_Homo sapiens_hsa005100.61576723
111Hematopoietic cell lineage_Homo sapiens_hsa046400.61167822
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60877189
113Dorso-ventral axis formation_Homo sapiens_hsa043200.60707269
114Proteasome_Homo sapiens_hsa030500.59679240
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58889092
116VEGF signaling pathway_Homo sapiens_hsa043700.57272257
117Pyruvate metabolism_Homo sapiens_hsa006200.57229733
118B cell receptor signaling pathway_Homo sapiens_hsa046620.56264661
119AMPK signaling pathway_Homo sapiens_hsa041520.55302725
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55245921
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.54998669
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54319982
123Asthma_Homo sapiens_hsa053100.54064681
124Endometrial cancer_Homo sapiens_hsa052130.53832516
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53476490
126Biosynthesis of amino acids_Homo sapiens_hsa012300.53216963
127Fatty acid degradation_Homo sapiens_hsa000710.52842379
128Prolactin signaling pathway_Homo sapiens_hsa049170.50608458
129Choline metabolism in cancer_Homo sapiens_hsa052310.46944315
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44686447
131Estrogen signaling pathway_Homo sapiens_hsa049150.43952649
132Inositol phosphate metabolism_Homo sapiens_hsa005620.43272065
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.41214499
134Folate biosynthesis_Homo sapiens_hsa007900.40155795
135FoxO signaling pathway_Homo sapiens_hsa040680.40076445
136Selenocompound metabolism_Homo sapiens_hsa004500.39290609
137Alcoholism_Homo sapiens_hsa050340.37272296
138GnRH signaling pathway_Homo sapiens_hsa049120.34566446

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